1. From near-infrared and Raman to surface-enhanced Raman spectroscopy: progress, limitations and perspectives in bioanalysis
- Author
-
Pierre-Yves Sacre, Elodie Dumont, Lauranne Netchacovitch, Philippe Hubert, Charlotte De Bleye, and Eric Ziemons
- Subjects
Bioanalysis ,Surface Properties ,Clinical Biochemistry ,Infrared spectroscopy ,Nanotechnology ,Context (language use) ,02 engineering and technology ,Spectrum Analysis, Raman ,01 natural sciences ,Analytical Chemistry ,Chemometrics ,symbols.namesake ,Animals ,Humans ,General Pharmacology, Toxicology and Pharmaceutics ,Immunoassay ,Spectroscopy, Near-Infrared ,Chemistry ,010401 analytical chemistry ,Near-infrared spectroscopy ,General Medicine ,Surface-enhanced Raman spectroscopy ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Medical Laboratory Technology ,symbols ,0210 nano-technology ,Raman spectroscopy ,Raman scattering - Abstract
Over recent decades, spreading environmental concern entailed the expansion of green chemistry analytical tools. Vibrational spectroscopy, belonging to this class of analytical tool, is particularly interesting taking into account its numerous advantages such as fast data acquisition and no sample preparation. In this context, near-infrared, Raman and mainly surface-enhanced Raman spectroscopy (SERS) have thus gained interest in many fields including bioanalysis. The two former techniques only ensure the analysis of concentrated compounds in simple matrices, whereas the emergence of SERS improved the performances of vibrational spectroscopy to very sensitive and selective analyses. Complex SERS substrates were also developed enabling biomarker measurements, paving the way for SERS immunoassays. Therefore, in this paper, the strengths and weaknesses of these techniques will be highlighted with a focus on recent progress.
- Published
- 2016