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7 results on '"Laura Steeples"'

1. Traumatic central serous chorioretinopathy

Author

Laura Steeples, Vinod Sharma, and Karl Mercieca

Subjects
Central serous chorioretinopathy, trauma, retina, Ophthalmology, RE1-994
Abstract

Central serous chorioretinopathy (CSR) is well described in the literature, with recognized associations such as systemic steroid therapy and stress; the association of blunt trauma with CSR is highly unusual. A 44-year-old male developed CSR rapidly after blunt trauma to his left eye with a significant reduction in visual acuity to hand movements. Serial optical coherence tomography and fundus fluorescein angiography images are presented. The patient was managed conservatively and spontaneous resolution occurred by 2 months with an excellent visual outcome. There was no evidence of an alternative underlying pathology for the presentation and particularly no signs of posterior uveitis. Investigations for an underlying vascular, inflammatory or infectious cause were all negative. The patient had previously had CSR in his other eye, and this may indicate a potential predisposition to developing the condition, triggered by blunt trauma.

Published
2015
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2. Authors′ response

Author

Laura Steeples, Vinod Sharma, and Karl Mercieca

Subjects
Ophthalmology, RE1-994
Published
2015

3. Guidance on noncorticosteroid systemic immunomodulatory therapy in noninfectious uveitis: fundamentals of care for uveitis (focus) initiative

Author

Dick, Andrew D., Fmedsci, FRCOphth Correspondence information about the author FMedSci, Dick†, FRCOphth Andrew D., Email the author FMedSci, Dick, FRCOphth Andrew D., Rosenbaum, James T., MD†, Al-Dhibi, Hassan A., Rubens Belfort, Jr., Phd, Md, Brézin, Antoine P., Soon Phaik Chee, Frcophth, Frcs, Davis, Janet L., Md, Ma, Ramanan, Athimalaipet V., Frcp, Frcpch, Koh-Hei, Sonoda, Ester, Carreño, Heloisa, Nascimento, Sawsen, Salah, Sherveen, Salek, Jay, Siak, Frcophth, FRCSEd(Ophth), Laura, Steeples, Frcophth, MBChB(Hons) Massimo Accorinti, Nisha, Acharya, Alfredo, Adan, Rupesh, Agrawal, Nurullah, Akkoc, Saed Al Ghamdi, Turki Al Ghamdi, Anood Al Saati, Nasser, Alsabaani, Mohamed, Al-Shamarani, Artur, Bachta, Talin, Barisani-Asenbauer, Nicholas, Beare, Fernanda Belga Ottoni Porto, Ricardo, Blanco, Anita Chan Sook Yee, Vinod, Chandran, Christophe, Chiquet, Hiok Hee Chng, Andrius, Cimbalas, Luca, Cimino, Miguel, Cordero-Coma, Couto, Cristobal, Miguel, Cuevas, João Eurico da Fonseca, Joke de Boer, Alejandra de la Torre, Ilse De Schryver, Larissa, Derzko-Dzulynsky, David, Diaz-Valle, Claudia Eugenia Duran Merino, Andrea, Facsko, Luis, Figueira, Alejandro, Fonollosa, Eric, Fortin, Richard, Gale, Mauro, Galeazzi, Sandra, Garcia, Jose Maria Garcia Ruiz de Morales, Nataša, Gašperšič, Debra, Goldstein, Marta, Guedes, Yan, Guex-Crosier, Ahmet, Gul, Rola, Hamam, Muhammad, Haroon, Kenichi, Hasegawa, Arnd, Heiligenhaus, Claire, Hooper, Yih-Shiou, Hwang, De-Kuang, Hwang, Xavier, Juanola, Toshikatsu, Kaburaki, Sibel, Kadayifcilar, John, Kempen, Takeshi, Kezuka, Amin, Kherani, Maarja, Kirsimäe, Kaisu, Kotaniemi, Aleksandra, Kraut, Agnieszka, Kubicka-Trząska, Lucia, Kuffova, Susan, Lightman, Lyndell, Lim, Wee Kiak Lim, Peter, Mccluskey, Mairide, Mcguire, Pierfrancesco, Mirabelli, Elisabetta, Miserocchi, Marta, Misiuk-Hojło, Cristina, Muccioli, Santiago, Muñoz, Conor, Murphy, Murray, Philip I., Zoltan, Nagy, Kenichi, Namba, Piergiorgio, Neri, Quan, Nguyen, Donncha, O'Gradaigh, Mohammed, Omair, Kati, Otsa, Yilmaz, Ozyazgan, Franco, Pablo, Paroli, Maria Pia, Uwe, Pleyer, Gyula, Poór, Rui, Proença, Theodore, Rabinovitch, Russell, Read, Margarita, Rebrov, Claudia, Recillas-Gispert, Aniki, Rothova, Sergio, Schwartzman, Pascal, Seve, Srilakshmi, Sharma, Joanne, Sims, Nicolette, Sohár, Eric, Suhler, Sándor, Szántó, Zsuzsanna, Szepessy, Christoph, Tappeiner, Jennifer, Thorne, Ilknur Tugal Tutkun, Anna, Turno-Kręcicka, Joachim Van Calster, Irene van der Horst-Bruinsma, Nataša Vidovič Valentinčič, Albert, Vitale, Stephanie Voorduin Ramos, Nenad, Vukojevic, Denis, Wakefield, François, Willermain, Nilufer, Yalcindag, Joyce Hisae Yamamoto, Stephen, Yeh, Reda, Zemaitiene, and Olga, Ziouzina

Subjects
biologic agents, immunomodulatory treatment, uveitis
Published
2018

4. Guidance on Noncorticosteroid Systemic Immunomodulatory Therapy in Noninfectious Uveitis

Author

Andrew D. Dick, James T. Rosenbaum, Hassan A. Al-Dhibi, Rubens Belfort, Antoine P. Brézin, Soon Phaik Chee, Janet L. Davis, Athimalaipet V. Ramanan, Koh-Hei Sonoda, Ester Carreño, Heloisa Nascimento, Sawsen Salah, Sherveen Salek, Jay Siak, Laura Steeples, Massimo Accorinti, Nisha Acharya, Alfredo Adan, Rupesh Agrawal, Nurullah Akkoc, Saed Al Ghamdi, Turki Al Ghamdi, Anood Al Saati, Nasser Alsabaani, Mohamed Al-Shamarani, Artur Bachta, Talin Barisani-Asenbauer, Nicholas Beare, Fernanda Belga Ottoni Porto, Ricardo Blanco, Anita Chan Sook Yee, Vinod Chandran, Christophe Chiquet, Hiok Hee Chng, Andrius Cimbalas, Luca Cimino, Miguel Cordero-Coma, Couto Cristobal, Miguel Cuevas, João Eurico da Fonseca, Joke de Boer, Alejandra de la Torre, Ilse De Schryver, Larissa Derzko-Dzulynsky, David Diaz-Valle, Claudia Eugenia Duran Merino, Andrea Facsko, Luis Figueira, Alejandro Fonollosa, Eric Fortin, Richard Gale, Mauro Galeazzi, Sandra Garcia, Jose Maria Garcia Ruiz de Morales, Nataša Gašperšič, Debra Goldstein, Marta Guedes, Yan Guex-Crosier, Ahmet Gul, Rola Hamam, Muhammad Haroon, Kenichi Hasegawa, Arnd Heiligenhaus, Claire Hooper, Yih-Shiou Hwang, De-Kuang Hwang, Xavier Juanola, Toshikatsu Kaburaki, Sibel Kadayifcilar, John Kempen, Takeshi Kezuka, Amin Kherani, Maarja Kirsimäe, Kaisu Kotaniemi, Aleksandra Kraut, Agnieszka Kubicka-Trząska, Lucia Kuffova, Susan Lightman, Lyndell Lim, Wee Kiak Lim, Peter McCluskey, Mairide McGuire, Pierfrancesco Mirabelli, Elisabetta Miserocchi, Marta Misiuk-Hojło, Cristina Muccioli, Santiago Muñoz, Conor Murphy, Philip I. Murray, Zoltan Nagy, Kenichi Namba, Piergiorgio Neri, Quan Nguyen, Donncha O'Gradaigh, Mohammed Omair, Kati Otsa, Yilmaz Ozyazgan, Franco Pablo, Maria Pia Paroli, Uwe Pleyer, Gyula Poór, Rui Proença, Theodore Rabinovitch, Russell Read, Margarita Rebrov, Claudia Recillas-Gispert, Aniki Rothova, Sergio Schwartzman, Pascal Seve, Srilakshmi Sharma, Joanne Sims, Nicolette Sohár, Eric Suhler, Sándor Szántó, Zsuzsanna Szepessy, Christoph Tappeiner, Jennifer Thorne, Ilknur Tugal Tutkun, Anna Turno-Kręcicka, Joachim Van Calster, Irene van der Horst-Bruinsma, Nataša Vidovič Valentinčič, Albert Vitale, Stephanie Voorduin Ramos, Nenad Vukojevic, Denis Wakefield, François Willermain, Nilufer Yalcindag, Joyce Hisae Yamamoto, Stephen Yeh, Reda Zemaitiene, and Olga Ziouzina

Subjects
030203 arthritis & rheumatology, medicine.medical_specialty, business.industry, MEDLINE, Retrospective cohort study, noninfectious uveitis, noncorticosteroid systemic immunomodulatory agents, Treatment consensus, Evidence-based medicine, CINAHL, Cochrane Library, medicine.disease, law.invention, 03 medical and health sciences, Ophthalmology, 0302 clinical medicine, Systematic review, Randomized controlled trial, law, Family medicine, 030221 ophthalmology & optometry, Medicine, business, Uveitis
Abstract

Topic: An international, expert-led consensus initiative to develop systematic, evidence-based recommendations for the treatment of noninfectious uveitis in the era of biologics. Clinical relevance: The availability of biologic agents for the treatment of human eye disease has altered practice patterns for the management of noninfectious uveitis. Current guidelines are insufficient to assure optimal use of noncorticosteroid systemic immunomodulatory agents. Methods: An international expert steering committee comprising 9 uveitis specialists (including both ophthalmologists and rheumatologists) identified clinical questions and, together with 6 bibliographic fellows trained in uveitis, conducted a Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol systematic review of the literature (English language studies from January 1996 through June 2016 ; Medline [OVID], the Central Cochrane library, EMBASE, CINAHL, SCOPUS, BIOSIS, and Web of Science). Publications included randomized controlled trials, prospective and retrospective studies with sufficient follow-up, case series with 15 cases or more, peer-reviewed articles, and hand-searched conference abstracts from key conferences. The proposed statements were circulated among 130 international uveitis experts for review. A total of 44 globally representative group members met in late 2016 to refine these guidelines using a modified Delphi technique and assigned Oxford levels of evidence. Results: In total, 10 questions were addressed resulting in 21 evidence-based guidance statements covering the following topics: when to start noncorticosteroid immunomodulatory therapy, including both biologic and nonbiologic agents ; what data to collect before treatment ; when to modify or withdraw treatment ; how to select agents based on individual efficacy and safety profiles ; and evidence in specific uveitic conditions. Shared decision-making, communication among providers and safety monitoring also were addressed as part of the recommendations. Pharmacoeconomic considerations were not addressed. Conclusions: Consensus guidelines were developed based on published literature, expert opinion, and practical experience to bridge the gap between clinical needs and medical evidence to support the treatment of patients with noninfectious uveitis with noncorticosteroid immunomodulatory agents.

Published
2018

5. Guidance on Noncorticosteroid Systemic Immunomodulatory Therapy in Noninfectious Uveitis: Fundamentals Of Care for UveitiS (FOCUS) Initiative

Author

Andrew D, Dick, James T, Rosenbaum, Hassan A, Al-Dhibi, Rubens, Belfort, Antoine P, Brézin, Soon Phaik, Chee, Janet L, Davis, Athimalaipet V, Ramanan, Koh-Hei, Sonoda, Ester, Carreño, Heloisa, Nascimento, Sawsen, Salah, Sherveen, Salek, Jay, Siak, Laura, Steeples, and Olga, Ziouzina

Subjects
Immunomodulation, Uveitis, Evidence-Based Medicine, Time Factors, Surveys and Questionnaires, Visual Acuity, Humans, Glucocorticoids, Risk Assessment, Immunosuppressive Agents
Abstract

An international, expert-led consensus initiative to develop systematic, evidence-based recommendations for the treatment of noninfectious uveitis in the era of biologics.The availability of biologic agents for the treatment of human eye disease has altered practice patterns for the management of noninfectious uveitis. Current guidelines are insufficient to assure optimal use of noncorticosteroid systemic immunomodulatory agents.An international expert steering committee comprising 9 uveitis specialists (including both ophthalmologists and rheumatologists) identified clinical questions and, together with 6 bibliographic fellows trained in uveitis, conducted a Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol systematic review of the literature (English language studies from January 1996 through June 2016; Medline [OVID], the Central Cochrane library, EMBASE, CINAHL, SCOPUS, BIOSIS, and Web of Science). Publications included randomized controlled trials, prospective and retrospective studies with sufficient follow-up, case series with 15 cases or more, peer-reviewed articles, and hand-searched conference abstracts from key conferences. The proposed statements were circulated among 130 international uveitis experts for review. A total of 44 globally representative group members met in late 2016 to refine these guidelines using a modified Delphi technique and assigned Oxford levels of evidence.In total, 10 questions were addressed resulting in 21 evidence-based guidance statements covering the following topics: when to start noncorticosteroid immunomodulatory therapy, including both biologic and nonbiologic agents; what data to collect before treatment; when to modify or withdraw treatment; how to select agents based on individual efficacy and safety profiles; and evidence in specific uveitic conditions. Shared decision-making, communication among providers and safety monitoring also were addressed as part of the recommendations. Pharmacoeconomic considerations were not addressed.Consensus guidelines were developed based on published literature, expert opinion, and practical experience to bridge the gap between clinical needs and medical evidence to support the treatment of patients with noninfectious uveitis with noncorticosteroid immunomodulatory agents.

Published
2017

6. Penetrating Keratoplasty for the Exciting Eye in Sympathetic Ophthalmia

Author

Laura Steeples, S Ramamurthi, Kanna Ramaesh, and Kurt S Cornish

Subjects
Adult, Male, Time Factors, Visual acuity, genetic structures, Visual Acuity, Ophthalmia, Medical Records, Eye injuries, medicine, Humans, Postoperative Period, business.industry, Sympathetic ophthalmia, Recovery of Function, Sympathetic ophthalmitis, medicine.disease, Eye Injuries, Penetrating, eye diseases, Ophthalmology, Ophthalmia, Sympathetic, Optometry, sense organs, medicine.symptom, business, Keratoplasty, Penetrating
Abstract

Purpose We report a case of sympathetic ophthalmitis where we performed penetrating keratoplasty on the exciting eye many years after the initial injury. Methods Case report. Results After penetrating keratoplasty, the patient achieved vision of 3/60 from preoperative perception of light. Conclusions Our experience shows that penetrating keratoplasty can restore useful vision in the previously injured exciting eye in sympathetic ophthalmitis. This case highlights a unique example where the inciting eye has ultimately become the eye with the better vision as the damage was limited.

Published
2008

7. Development of a Nationally Agreed Core Clinical Dataset for Childhood Onset Uveitis

Author

Ameenat Lola Solebo, Salomey Kellett, Jugnoo Rahi, Reshma Pattani, Clive Edelsten, Andrew D. Dick, Alastair Denniston, The Pediatric Ocular Inflammation UNICORN Study Group, Ms Ameenat Lola Solebo, Ms Salomey Kellett, Professor Andrew D Dick, Professor Jugnoo Rahi, Professor Alastair Denniston, Mr Damien C.M. Yeo, Mr Jose Gonzalez-Martin, Ms Eibhlin McLoone, Prof Rachel Pilling, Mr John Bradbury, Prof Athimalaipet V Ramanan, Ms Catherine Guly, Ms Brinda Muthusamy, Mr Patrick Watts, Ms Christine Twomey, Ms Reshma Pattani, Mr Clive Edelsten, Mr Daniel Pharoah, Mr Vernon Long, Mr Adam Bates, Ms Elisabetta Scoppettuolo, Prof Jane Ashworth, Ms Laura Steeples, Mr Harry Petrushkin, Ms Dhanes Thomas, Mr Alan John Connor, Dr Una O'Colmain, Mr Anas Injarie, Mr Narman Puvanachandra, Ms Archana Pradeep, Ms Srilakshmi Sharma, Dr Conrad Schmoll, Dr Eoghan Millar, Mrs Kate Bush, Mr M. Ashwin Reddy, Ms Jessy Choi, Ms Gisella Cooper, Ms Kristina May, Mr Ed Hughes, and Ms Ailsa Ritchie

Subjects
uveitis, child, consensus, data collection, dataset, electronic health record, Pediatrics, RJ1-570
Abstract

BackgroundChildhood onset uveitis comprises a group of rare inflammatory disorders characterized by clinical heterogeneity, chronicity, and uncertainties around long term outcomes. Standardized, detailed datasets with harmonized clinical definitions and terminology are needed to enable the clinical research necessary to stratify disease phenotype and interrogate the putative determinants of health outcomes. We aimed to develop a core routine clinical collection dataset for clinicians managing children with uveitis, suitable for multicenter and national clinical and experimental research initiatives.MethodsDevelopment of the dataset was undertaken in three phases: phase 1, a rapid review of published datasets used in clinical research studies; phase 2, a scoping review of disease or drug registries, national cohort studies and core outcome sets; and phase 3, a survey of members of a multicenter clinical network of specialists. Phases 1 and 2 provided candidates for a long list of variables for the dataset. In Phase 3, members of the UK's national network of stakeholder clinicians who manage childhood uveitis (the Pediatric Ocular Inflammation Group) were invited to select from this long-list their essential items for the core clinical dataset, to identify any omissions, and to support or revise the clinical definitions. Variables which met a threshold of at least 95% agreement were selected for inclusion in the core clinical dataset.ResultsThe reviews identified 42 relevant studies, and 9 disease or drug registries. In total, 138 discrete items were identified as candidates for the long-list. Of the 41 specialists invited to take part in the survey, 31 responded (response rate 78%). The survey resulted in inclusion of 89 data items within the final core dataset: 81 items to be collected at the first visit, and 64 items at follow up visits.DiscussionWe report development of a novel consensus core clinical dataset for the routine collection of clinical data for children diagnosed with non-infectious uveitis. The development of the dataset will provide a standardized approach to data capture able to support observational clinical studies embedded within routine clinical care and electronic patient record capture. It will be validated through a national prospective cohort study, the Uveitis in childhood prospective national cohort study (UNICORNS).

Published
2022
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