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1. Exchange catalysis by tapasin exploits conserved and allele-specific features of MHC-I molecules

Author

Huan Lan, Esam T. Abualrous, Jana Sticht, Laura Maria Arroyo Fernandez, Tamina Werk, Christoph Weise, Martin Ballaschk, Peter Schmieder, Bernhard Loll, and Christian Freund

Subjects
Science
Abstract

Tapasin is part of the peptide loading complex necessary for presenting antigenic peptides on MHC-I for the induction of adaptive immunity. Here the authors show that tapasin interacts with MHC-I in both conserved and allele-specific regions to promote antigen presentation, with tapasin L18 and K16 residues both implicated in this molecular interaction.

Published
2021
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