Author: "Laura Gomez" - Searchworks@Jio Institute Digital Library Search Results

499 results on '"Laura Gomez"'

1. Using matrix assisted laser desorption ionisation mass spectrometry combined with machine learning for vaccine authenticity screening

Author: Rebecca Clarke, Tehmina Bharucha, Benediktus Yohan Arman, Bevin Gangadharan, Laura Gomez Fernandez, Sara Mosca, Qianqi Lin, Kerlijn Van Assche, Robert Stokes, Susanna Dunachie, Michael Deats, Hamid A. Merchant, Céline Caillet, John Walsby-Tickle, Fay Probert, Pavel Matousek, Paul N. Newton, Nicole Zitzmann, and James S. O. McCullagh
Subjects: Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Abstract The global population is increasingly reliant on vaccines to maintain population health with billions of doses used annually in immunisation programmes. Substandard and falsified vaccines are becoming more prevalent, caused by both the degradation of authentic vaccines but also deliberately falsified vaccine products. These threaten public health, and the increase in vaccine falsification is now a major concern. There is currently no coordinated global infrastructure or screening methods to monitor vaccine supply chains. In this study, we developed and validated a matrix-assisted laser desorption/ionisation-mass spectrometry (MALDI-MS) workflow that used open-source machine learning and statistical analysis to distinguish authentic and falsified vaccines. We validated the method on two different MALDI-MS instruments used worldwide for clinical applications. Our results show that multivariate data modelling and diagnostic mass spectra can be used to distinguish authentic and falsified vaccines providing proof-of-concept that MALDI-MS can be used as a screening tool to monitor vaccine supply chains.
Published: 2024
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2. Racial and ethnic disparities post-hospitalization for COVID-19: barriers to access to care for survivors of COVID-19 acute respiratory distress syndrome

Author: Alicia Cañas, Allison Wolf, Angela Mak, Jacob Ruddy, Sal El-Sadek, Laura Gomez, David Furfaro, Robert Fullilove, Kristin M. Burkart, Jennifer Zelnick, and Max R. O’Donnell
Subjects: COVID-19, Long COVID, ARDS, Racial and ethnic disparities, Access to care, Medicine, Science
Abstract: Abstract Racial and ethnic health disparities in the incidence and severity of Coronavirus Disease 2019 (COVID-19) have been observed globally and in the United States. Research has focused on transmission, hospitalization, and mortality among racial and ethnic minorities, but Long COVID-19 health disparities research is limited. This study retrospectively evaluated 195 adults who survived COVID-19 associated acute respiratory distress syndrome (C-ARDS) in New York City from March–April 2020. Among survivors, 54% met the criteria for Long COVID syndrome. Hispanic/Latinx patients, were more likely to be uninsured (p = 0.027) and were less frequently discharged to rehabilitation facilities (p
Published: 2024
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3. Case Report: Micafungin for treating Candida glabrata urinary infection: a clinical case in a premature neonate

Author: Carlos Javier Parramon-Teixido, Carme Garcia Esquerda, Marie Antoinette Frick, Cinzia Tripodi, Laura Gomez-Ganda, Cesar Wenceslao Ruiz-Campillo, and Maria Josep Cabañas-Poy
Subjects: Candida glabrata, micafungin, urinary tract infection, premature infant, case report, Pediatrics, RJ1-570
Abstract: Urinary tract infections (UTIs) associated with indwelling urinary catheterization (IUC) in premature newborns (PNBs) pose a significant challenge in neonatal intensive care units (NICUs) due to the vulnerability of this population to infections and the necessity of invasive procedures. While bacterial UTIs have historically been predominant, there is a rising incidence of fungal pathogens, particularly non-albicans Candida strains like Candida glabrata and Candida tropicalis, attributed to broad-spectrum antibiotic use. Diagnosis of fungal UTIs in a PNB relies on culturing Candida spp. from properly collected urine samples, particularly critical in very low birth weight (VLBW) PNBs because of the risk of invasive candidiasis and associated complications. We present a case of an extremely premature newborn (EPNB) successfully treated for a UTI caused by C. glabrata with micafungin. Our case exhibits micafungin as a potentially safe and effective alternative for treating C. glabrata UTIs in neonates.
Published: 2024
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4. Structural basis for the toxicity of Legionella pneumophila effector SidH

Author: Rahul Sharma, Michael Adams, Simonne Griffith-Jones, Tobias Sahr, Laura Gomez-Valero, Felix Weis, Michael Hons, Sarah Gharbi, Rayene Berkane, Alexandra Stolz, Carmen Buchrieser, and Sagar Bhogaraju
Subjects: Science
Abstract: Abstract Legionella pneumophila (LP) secretes more than 300 effectors into the host cytosol to facilitate intracellular replication. One of these effectors, SidH, 253 kDa in size with no sequence similarity to proteins of known function is toxic when overexpressed in host cells. SidH is regulated by the LP metaeffector LubX which targets SidH for degradation in a temporal manner during LP infection. The mechanism underlying the toxicity of SidH and its role in LP infection are unknown. Here, we determined the cryo-EM structure of SidH at 2.7 Å revealing a unique alpha helical arrangement with no overall similarity to known protein structures. Surprisingly, purified SidH came bound to a E. coli EF-Tu/t-RNA/GTP ternary complex which could be modeled into the cryo-EM density. Mutation of residues disrupting the SidH-tRNA interface and SidH-EF-Tu interface abolish the toxicity of overexpressed SidH in human cells, a phenotype confirmed in infection of Acanthamoeba castellani. We also present the cryo-EM structure of SidH in complex with a U-box domain containing ubiquitin ligase LubX delineating the mechanism of regulation of SidH. Our data provide the basis for the toxicity of SidH and into its regulation by the metaeffector LubX.
Published: 2023
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5. The SET and ankyrin domains of the secreted Legionella pneumophila histone methyltransferase work together to modify host chromatin

Author: Monica Rolando, Ivy Yeuk Wah Chung, Caishuang Xu, Laura Gomez-Valero, Patrick England, Miroslaw Cygler, and Carmen Buchrieser
Subjects: Legionella pneumophila, host-pathogen interactions, histone methyltransferase, epigenetics, H3K14, Microbiology, QR1-502
Abstract: ABSTRACT Legionella pneumophila is a bacterial pathogen ubiquitous in natural and man-made aquatic environments, where it replicates in protozoa. Its intracellular life cycle depends on the establishment of a Legionella-containing vacuole (LCV) where the bacteria replicate. To form the LCV, L. pneumophila depends on a type-4 secretion system that secretes more than 300 proteins in the host cell. Among these is RomA that encodes an N-terminal catalytic methyltransferase domain with a SET fold and a C-terminal domain containing six ankyrin repeats. We have reported that the SET domain has histone methyltransferase activity and specifically methylates lysine 14 of histone H3 during infection; however, the role of the ankyrin repeats is unknown. Here, we report the structure of RomA co-crystallized with a 15-mer peptide corresponding to the N-terminal tail of histone H3 at 2.2 Å. This structure revealed that the N-terminal arm of the peptide from Thr3-Ala7 binds to the ankyrin repeat domain and the C-terminal arm from Gly13-Arg17 and interacts with the SET domain, inserting Lys14 into the active site for methylation. Importantly, the interactions of the five N-terminal residues of the H3-peptide with the ankyrin domains account for ~50% of the peptide-RomA contacts, predicting that the ankyrin domains of RomA are essential for histone H3 binding and subsequent lysine methylation. In vitro enzymatic activity and binding assays confirmed these predictions. Thus, the six ankyrin domains are essential for chromatin binding, thereby allowing the SET domain to fulfill its histone transferase activity and to modify the host chromatin to the advantage of the pathogen. IMPORTANCE Legionella pneumophila is an intracellular bacterium responsible of Legionnaires’ disease, a severe pneumonia that is often fatal when not treated promptly. The pathogen’s ability to efficiently colonize the host resides in its ability to replicate intracellularly. Essential for intracellular replication is translocation of many different protein effectors via a specialized secretion system. One of them, called RomA, binds and directly modifies the host chromatin at a unique site (tri-methylation of lysine 14 of histone H3 [H3K14me]). However, the molecular mechanisms of binding are not known. Here, we resolve this question through structural characterization of RomA together with the H3 peptide. We specifically reveal an active role of the ankyrin repeats located in its C-terminal in the interaction with the histone H3 tail. Indeed, without the ankyrin domains, RomA loses its ability to act as histone methyltransferase. These results discover the molecular mechanisms by which a bacterial histone methyltransferase that is conserved in L. pneumophila strains acts to modify chromatin.
Published: 2023
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6. P1569: HERPES ZOSTER VACCINATION IN HEMATOLOGY. A SINGLE CENTER EXPERIENCE.

Author: Natalia De Las Heras Rodriguez, Fernando Escalante, Laura Gomez del Campo, and María Jesús Vidal
Subjects: Diseases of the blood and blood-forming organs, RC633-647.5
Published: 2023
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7. Genomic erosion and horizontal gene transfer shape functional differences of the ExlA toxin in Pseudomonas spp.

Author: Viviana Job, Laura Gomez-Valero, Adèle Renier, Christophe Rusniok, Stephanie Bouillot, Viviane Chenal-Francisque, Erwan Gueguen, Annie Adrait, Mylène Robert-Genthon, Katy Jeannot, Peter Panchev, Sylvie Elsen, Marie-Odile Fauvarque, Yohann Couté, Carmen Buchrieser, and Ina Attrée
Subjects: Genetics, Microbiology, Science
Abstract: Summary: Two-partner secretion (TPS) is widespread in the bacterial world. The pore-forming TPS toxin ExlA of Pseudomonas aeruginosa is conserved in pathogenic and environmental Pseudomonas. While P. chlororaphis and P. entomophila displayed ExlA-dependent killing, P. putida did not cause damage to eukaryotic cells. ExlA proteins interacted with epithelial cell membranes; however, only ExlAPch induced the cleavage of the adhesive molecule E-cadherin. ExlA proteins participated in insecticidal activity toward the larvae of Galleria mellonella and the fly Drosophila melanogaster. Evolutionary analyses demonstrated that the differences in the C-terminal domains are partly due to horizontal movements of the operon within the genus Pseudomonas. Reconstruction of the evolutionary history revealed the complex horizontal acquisitions. Together, our results provide evidence that conserved TPS toxins in environmental Pseudomonas play a role in bacteria-insect interactions and discrete differences in CTDs may determine their specificity and mode of action toward eukaryotic cells.
Published: 2022
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8. Risk definition and outcomes with the application of the PEGASUS-TIMI 54 trial inclusion criteria to a 'real world' STEMI population: results from the Italian 'CARDIO-STEMI SANREMO' registry

Author: Federico Sanchez, Valentina Boasi, Matteo Vercellino, Chiara Tacchi, Pierpaolo Cannarile, Nicoletta Pingelli, Dino Perri, Laura Gomez, Stefano Cattunar, and Giovanni Mascelli
Subjects: Bleeding risk, Dual antiplatelet therapy, Ischemic risk, STEMI outcome, STEMI registry, Ticagrelor, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Abstract Background The PEGASUS-TIMI 54 trial inclusion criteria effectively identified high-risk patients with recent myocardial infarction (MI) who would benefit from continuing dual antiplatelet therapy (DAPT) with ticagrelor for more than 12 months. It is unknown how many real-world patients meet these criteria during the acute phase of ST-elevation MI (STEMI), or the extent to which these criteria predict a patient's risk and prognosis. Study objectives were: (1) determine the proportion of PEGASUS-TIMI 54-like patients (PG-l) in a real-world cohort of patients hospitalized with STEMI and to assess their ischemic and hemorrhagic risk; (2) examine their ischemic and hemorrhagic in-hospital events (major adverse cardiovascular and cerebrovascular events [MACCE] and clinically relevant bleeding); (3) evaluate their long-term outcomes and the impact on the long-term prognosis of the type of DAPT prescribed at discharge. Methods This observational study was conducted in 1086 patients admitted to hospital with a diagnosis of STEMI between February 2011 and March 2018 and enrolled in the CARDIO-STEMI Sanremo registry. Patients’ demographic and clinical characteristics, procedural variables, and individual ischemic and hemorrhagic risk scores were assessed in-hospital. Four-year survival was also analyzed. Results The proportion of PG-I patients was 69.2%. Compared with non-PG-l patients, PG-l patients were older, had more multivessel disease and comorbidities, and experienced more frequent MACCE (8.3% vs. 3.6%, p = 0.005) and clinically significant bleeding events (6.7% vs. 2.7%, p = 0.008), a higher rate of in-hospital death (6.5% vs. 1.5%, p
Published: 2021
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9. SARS-CoV-2 Genome Variations in Viral Shedding of an Immunocompromised Patient with Non-Hodgkin’s Lymphoma

Author: Rodrigo Villaseñor-Echavarri, Laura Gomez-Romero, Alexandra Martin-Onraet, Luis A. Herrera, Marco A. Escobar-Arrazola, Oscar A. Ramirez-Vega, Corazón Barrientos-Flores, Alfredo Mendoza-Vargas, Alfredo Hidalgo-Miranda, Diana Vilar-Compte, and Alberto Cedro-Tanda
Subjects: SARS-CoV-2, COVID-19, mutational landscape, non-Hodgkin’s lymphoma, Microbiology, QR1-502
Abstract: Background. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19) is the most transmissible ß-coronavirus in history, affecting all population groups. Immunocompromised patients, particularly cancer patients, have been highlighted as a reservoir to promote accumulation of viral mutations throughout persistent infection. Case presentation. We aimed to describe the clinical course and SARS-CoV-2 mutation profile for 102 days in an immunocompromised patient with non-Hodgkin’s lymphoma and COVID-19. We used RT-qPCR to quantify SARS-CoV-2 viral load over time and whole-virus genome sequencing to identify viral lineage and mutation profile. The patient presented with a persistent infection through 102 days while being treated with cytotoxic chemotherapy for non-Hodgkin’s lymphoma and received targeted therapy for COVID-19 with remdesivir and hyperimmune plasma. All sequenced samples belonged to the BA.1.1 lineage. We detected nine amino acid substitutions in five viral genes (Nucleocapsid, ORF1a, ORF1b, ORF13a, and ORF9b), grouped in two clusters: the first cluster with amino acid substitutions only detected on days 39 and 87 of sample collection, and the second cluster with amino acid substitutions only detected on day 95 of sample collection. The Spike gene remained unchanged in all samples. Viral load was dynamic but consistent with the disease flares. Conclusions. This report shows that the multiple mutations that occur in an immunocompromised patient with persistent COVID-19 could provide information regarding viral evolution and emergence of new SARS-CoV-2 variants.
Published: 2023
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10. Use of Eculizumab in Pediatric Patients With Transplant Associated Thrombotic Microangiopathy

Author: Laura Gomez-Ganda, Maria Isabel Benitez-Carabante, Aurora Fernandez-Polo, Marina Muñoz-Lopez, Berta Renedo-Miro, Gema Ariceta, and Cristina Diaz De Heredia
Subjects: thrombotic microangiopathy (TA-TMA), hrTA-TMA, eculizumab, complement system, hematopoietic stem cell transplant (HSCT), CH50, Pediatrics, RJ1-570
Abstract: Background: Transplant-associated thrombotic microangiopathy (TA-TMA) is a serious complication of hematopoietic stem cell transplantation (HSCT) associated with high morbidity and mortality. High-risk TA-TMA (hrTA-TMA) is characterized by multifactorial endothelial damage caused by environmental stressors, dysregulation of the complement system, and genetic predisposition. Complement inhibitors have significantly decreased mortality and are the current treatment of choice. In this article, we describe our experience with the use of eculizumab in pediatric patients diagnosed with hrT-TMA after HSCT.Method: Retrospective study of pediatric patients with hrTA-TMA treated with eculizumab between January 2016 and December 2020.Results: Four pediatric patients aged 1, 12, 14, and 17 years at the time of HSCT were diagnosed with hrTA-TMA and treated with eculizumab during the study. At diagnosis, they all had renal impairment with proteinuria, and hypertension under treatment with at least two antihypertensive drugs. The patient who presented multisystemic involvement died instead of treatment. The three patients with exclusive renal involvement achieved TA-TMA resolution after treatment with eculizumab for 65, 52, and 40.6 weeks and were able to stop treatment. The two patients with follow-up data one year after eculizumab withdrawal sustained a favorable response. Eculizumab was well tolerated, and with adequate vaccination and antibiotic prophylaxis, did not increase the risk of infection.Conclusions: Eculizumab appears to be both safe and effective for the treatment of hrTA-TMA in patients with renal impairment. Early diagnosis and initiation of treatment may improve response. Eculizumab withdrawal can be contemplated in patients who achieve laboratory and clinical resolution of TA-TMA.
Published: 2021
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11. The progressive gendering of the European Union’s economic governance architecture

Author: Laura Gomez Urquijo
Subjects: Gender, EU, Governance, Social policy, Political science, Social Sciences
Abstract: This study shows the correlation between the European integration process and the progress of gender equality objectives. In particular, it focuses on the effectiveness of economic governance tools to enhance coordination between national policies towards gender equality. The research question pertains to whether the new architecture of economic governance aims to consolidate the market model or correct gender imbalances. This aspect leads us to explore the diverse tools of national monitoring displayed in the recently reinforced governance, particularly the fiscal discipline policy as a conditioning framework, the European Semester as the current significant instrument for coordinating national policies, and the European Pillar of Social Rights (EPSR) and its Social Scoreboard annex. The analysis confirms that the potential of governance instruments to enhance gender equality is underused. Meanwhile, these tools set out a policy focused on consolidating the market model of competitiveness and fiscal discipline, rather than tackling gender inequalities
Published: 2021
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12. The Autophagy Protein Pacer Positively Regulates the Therapeutic Potential of Mesenchymal Stem Cells in a Mouse Model of DSS-Induced Colitis

Author: Cristian A. Bergmann, Sebastian Beltran, Ana Maria Vega-Letter, Paola Murgas, Maria Fernanda Hernandez, Laura Gomez, Luis Labrador, Bastián I. Cortés, Cristian Poblete, Cristobal Quijada, Flavio Carrion, Ute Woehlbier, and Patricio A. Manque
Subjects: autophagy, PACER, KIAA0226L, RUBCNL, therapy, inflammatory bowel disease, Cytology, QH573-671
Abstract: Mesenchymal stem cells (MSC) have emerged as a promising tool to treat inflammatory diseases, such as inflammatory bowel disease (IBD), due to their immunoregulatory properties. Frequently, IBD is modeled in mice by using dextran sulfate sodium (DSS)-induced colitis. Recently, the modulation of autophagy in MSC has been suggested as a novel strategy to improve MSC-based immunotherapy. Hence, we investigated a possible role of Pacer, a novel autophagy enhancer, in regulating the immunosuppressive function of MSC in the context of DSS-induced colitis. We found that Pacer is upregulated upon stimulation with the pro-inflammatory cytokine TNFα, the main cytokine released in the inflammatory environment of IBD. By modulating Pacer expression in MSC, we found that Pacer plays an important role in regulating the autophagy pathway in this cell type in response to TNFα stimulation, as well as in regulating the immunosuppressive ability of MSC toward T-cell proliferation. Furthermore, increased expression of Pacer in MSC enhanced their ability to ameliorate the symptoms of DSS-induced colitis in mice. Our results support previous findings that autophagy regulates the therapeutic potential of MSC and suggest that the augmentation of autophagic capacity in MSC by increasing Pacer levels may have therapeutic implications for IBD.
Published: 2022
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13. Radiation and Dust Sensor for Mars Environmental Dynamic Analyzer Onboard M2020 Rover

Author: Victor Apestigue, Alejandro Gonzalo, Juan J. Jiménez, Justin Boland, Mark Lemmon, Jose R. de Mingo, Elisa García-Menendez, Joaquín Rivas, Joaquín Azcue, Laurent Bastide, Nuria Andrés-Santiuste, Javier Martínez-Oter, Miguel González-Guerrero, Alberto Martin-Ortega, Daniel Toledo, Francisco Javier Alvarez-Rios, Felipe Serrano, Boris Martín-Vodopivec, Javier Manzano, Raquel López Heredero, Isaías Carrasco, Sergio Aparicio, Ángel Carretero, Daniel R. MacDonald, Lori B. Moore, María Ángeles Alcacera, Jose A. Fernández-Viguri, Israel Martín, Margarita Yela, Maite Álvarez, Paula Manzano, Jose A. Martín, Juan C. del Hoyo, Manuel Reina, Roser Urqui, Jose A. Rodriguez-Manfredi, Manuel de la Torre Juárez, Christina Hernandez, Elizabeth Cordoba, Robin Leiter, Art Thompson, Soren Madsen, Michael D. Smith, Daniel Viúdez-Moreiras, Alfonso Saiz-Lopez, Agustín Sánchez-Lavega, Laura Gomez-Martín, Germán M. Martínez, Francisco J. Gómez-Elvira, and Ignacio Arruego
Subjects: Mars, Mars 2020, MEDA, RDS, instrumentation, atmosphere, Chemical technology, TP1-1185
Abstract: The Radiation and Dust Sensor is one of six sensors of the Mars Environmental Dynamics Analyzer onboard the Perseverance rover from the Mars 2020 NASA mission. Its primary goal is to characterize the airbone dust in the Mars atmosphere, inferring its concentration, shape and optical properties. Thanks to its geometry, the sensor will be capable of studying dust-lifting processes with a high temporal resolution and high spatial coverage. Thanks to its multiwavelength design, it will characterize the solar spectrum from Mars’ surface. The present work describes the sensor design from the scientific and technical requirements, the qualification processes to demonstrate its endurance on Mars’ surface, the calibration activities to demonstrate its performance, and its validation campaign in a representative Mars analog. As a result of this process, we obtained a very compact sensor, fully digital, with a mass below 1 kg and exceptional power consumption and data budget features.
Published: 2022
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14. Testicular Germ Cell Tumours and Proprotein Convertases

Author: Aitziber Velado-Eguskiza, Laura Gomez-Santos, Iker Badiola, Francisco José Sáez, and Edurne Alonso
Subjects: testicular cancer, Testicular Germ Cell Tumours (TGCT), seminoma, spermatogenesis, Proprotein Convertases (PCs), Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Testicular Germ Cell Tumours (TGCT) are widely considered a “curable cancer” due to their exceptionally high survival rate, even if it is reduced by many years after the diagnosis due to metastases and relapses. The most common therapeutic approach to TGCTs has not changed in the last 50 years despite its multiple long-term side effects, and because it is the most common malignancy in young Caucasian men, much research is needed to better the quality of life of the many survivors. Proprotein Convertases (PC) are nine serine proteases responsible for the maturation of inactive proproteins with many diverse functions. Alterations in their expression have been associated with various diseases, including cancer and inflammation. Many of their substrates are adhesion molecules, metalloproteases and proinflammatory molecules, all of which are involved in tumour development. Inhibition of certain convertases has also been shown to slow tumour formation, demonstrating their involvement in this process. Considering the very established link between PCs and inflammation-related malignancies and the recent studies carried out into the immune microenvironment of TGCTs, the study of the involvement of PCs in testicular cancer may open up avenues for being both a biomarker for diagnosis and a therapeutic target.
Published: 2022
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15. mHealth app using machine learning to increase physical activity in diabetes and depression: clinical trial protocol for the DIAMANTE Study

Author: Urmimala Sarkar, Jing Xu, Bibhas Chakraborty, Adrian Aguilera, Caroline A Figueroa, Rosa Hernandez-Ramos, Anupama Cemballi, Laura Gomez-Pathak, Jose Miramontes, Elad Yom-Tov, Xiaoxi Yan, Arghavan Modiri, Jai Aggarwal, Joseph Jay Williams, and Courtney R Lyles
Subjects: Medicine
Abstract: Introduction Depression and diabetes are highly disabling diseases with a high prevalence and high rate of comorbidity, particularly in low-income ethnic minority patients. Though comorbidity increases the risk of adverse outcomes and mortality, most clinical interventions target these diseases separately. Increasing physical activity might be effective to simultaneously lower depressive symptoms and improve glycaemic control. Self-management apps are a cost-effective, scalable and easy access treatment to increase physical activity. However, cutting-edge technological applications often do not reach vulnerable populations and are not tailored to an individual’s behaviour and characteristics. Tailoring of interventions using machine learning methods likely increases the effectiveness of the intervention.Methods and analysis In a three-arm randomised controlled trial, we will examine the effect of a text-messaging smartphone application to encourage physical activity in low-income ethnic minority patients with comorbid diabetes and depression. The adaptive intervention group receives messages chosen from different messaging banks by a reinforcement learning algorithm. The uniform random intervention group receives the same messages, but chosen from the messaging banks with equal probabilities. The control group receives a weekly mood message. We aim to recruit 276 adults from primary care clinics aged 18–75 years who have been diagnosed with current diabetes and show elevated depressive symptoms (Patient Health Questionnaire depression scale-8 (PHQ-8) >5). We will compare passively collected daily step counts, self-report PHQ-8 and most recent haemoglobin A1c from medical records at baseline and at intervention completion at 6-month follow-up.Ethics and dissemination The Institutional Review Board at the University of California San Francisco approved this study (IRB: 17-22608). We plan to submit manuscripts describing our user-designed methods and testing of the adaptive learning algorithm and will submit the results of the trial for publication in peer-reviewed journals and presentations at (inter)-national scientific meetings.Trial registration number NCT03490253; pre-results.
Published: 2020
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16. Divergent Evolution of Legionella RCC1 Repeat Effectors Defines the Range of Ran GTPase Cycle Targets

Author: A. Leoni Swart, Bernhard Steiner, Laura Gomez-Valero, Sabina Schütz, Mandy Hannemann, Petra Janning, Michael Irminger, Eva Rothmeier, Carmen Buchrieser, Aymelt Itzen, Vikram Govind Panse, and Hubert Hilbi
Subjects: amoeba, bacterial evolution, Acanthamoeba, Dictyostelium, effector protein, guanine nucleotide exchange factor, Microbiology, QR1-502
Abstract: ABSTRACT Legionella pneumophila governs its interactions with host cells by secreting >300 different “effector” proteins. Some of these effectors contain eukaryotic domains such as the RCC1 (regulator of chromosome condensation 1) repeats promoting the activation of the small GTPase Ran. In this report, we reveal a conserved pattern of L. pneumophila RCC1 repeat genes, which are distributed in two main clusters of strains. Accordingly, strain Philadelphia-1 contains two RCC1 genes implicated in bacterial virulence, legG1 (Legionella eukaryotic gene 1), and ppgA, while strain Paris contains only one, pieG. The RCC1 repeat effectors localize to different cellular compartments and bind distinct components of the Ran GTPase cycle, including Ran modulators and the small GTPase itself, and yet they all promote the activation of Ran. The pieG gene spans the corresponding open reading frames of legG1 and a separate adjacent upstream gene, lpg1975. legG1 and lpg1975 are fused upon addition of a single nucleotide to encode a protein that adopts the binding specificity of PieG. Thus, a point mutation in pieG splits the gene, altering the effector target. These results indicate that divergent evolution of RCC1 repeat effectors defines the Ran GTPase cycle targets and that modulation of different components of the cycle might fine-tune Ran activation during Legionella infection. IMPORTANCE Legionella pneumophila is a ubiquitous environmental bacterium which, upon inhalation, causes a life-threatening pneumonia termed Legionnaires’ disease. The opportunistic pathogen grows in amoebae and macrophages by employing a “type IV” secretion system, which secretes more than 300 different “effector” proteins into the host cell, where they subvert pivotal processes. The function of many of these effector proteins is unknown, and their evolution has not been studied. L. pneumophila RCC1 repeat effectors target the small GTPase Ran, a molecular switch implicated in different cellular processes such as nucleocytoplasmic transport and microtubule cytoskeleton dynamics. We provide evidence that one or more RCC1 repeat genes are distributed in two main clusters of L. pneumophila strains and have divergently evolved to target different components of the Ran GTPase activation cycle at different subcellular sites. Thus, L. pneumophila employs a sophisticated strategy to subvert host cell Ran GTPase during infection.
Published: 2020
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17. Short genome report of cellulose-producing commensal Escherichia coli 1094

Author: Joaquin Bernal-Bayard, Laura Gomez-Valero, Aimee Wessel, Varun Khanna, Christiane Bouchier, and Jean-Marc Ghigo
Subjects: E. coli, Commensal, Biofilm, Cellulose, Extracellular matrix, Bcs operon, Genetics, QH426-470
Abstract: Abstract Bacterial surface colonization and biofilm formation often rely on the production of an extracellular polymeric matrix that mediates cell-cell and cell-surface contacts. In Escherichia coli and many Betaproteobacteria and Gammaproteobacteria cellulose is often the main component of the extracellular matrix. Here we report the complete genome sequence of the cellulose producing strain E. coli 1094 and compare it with five other closely related genomes within E. coli phylogenetic group A. We present a comparative analysis of the regions encoding genes responsible for cellulose biosynthesis and discuss the changes that could have led to the loss of this important adaptive advantage in several E. coli strains. Data deposition: The annotated genome sequence has been deposited at the European Nucleotide Archive under the accession number PRJEB21000.
Published: 2018
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18. Effectiveness of Stretching in Post-Stroke Spasticity and Range of Motion: Systematic Review and Meta-Analysis

Author: Laura Gomez-Cuaresma, David Lucena-Anton, Gloria Gonzalez-Medina, Francisco Javier Martin-Vega, Alejandro Galan-Mercant, and Carlos Luque-Moreno
Subjects: stroke, muscle spasticity, muscle stretching exercises, activities of daily living, Medicine
Abstract: Spasticity is one of the most frequent and disabling clinical manifestations of patients with stroke. In clinical practice, stretching is the most widely used physiotherapeutic intervention for this population. However, there is no solid evidence for its effectiveness. The aim of this study was to evaluate the effectiveness of different types of stretching in reducing post-stroke spasticity. Research was carried out until March 2021 in the following scientific databases: PubMed, CINAHL, Scopus, Cochrane Library, Web of Science, and PEDro. The PEDro scale and the Cochrane collaboration tool were used to assess the methodological quality and risk of bias of the studies. Eight articles were selected for qualitative analysis; six of them contributed information to the meta-analysis. No conclusive evidence was obtained on the effectiveness of stretching in terms of treating spasticity and range of motion in patients with stroke. Further research is necessary in order to determine the effectiveness of the use of stretching in this population, considering the different types of stretching (static and dynamic), the time of application, the measurement of the different components of spasticity, and the extrapolation of functional results.
Published: 2021
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19. Polar Stratospheric Clouds Detection at Belgrano II Antarctic Station with Visible Ground-Based Spectroscopic Measurements

Author: Laura Gomez-Martin, Daniel Toledo, Cristina Prados-Roman, Jose Antonio Adame, Hector Ochoa, and Margarita Yela
Subjects: polar stratospheric clouds, color index, radiative transfer model, visible spectroscopy, Science
Abstract: By studying the evolution of the color index (CI) during twilight at high latitudes, polar stratospheric clouds (PSCs) can be detected and characterized. In this work, this method has been applied to the measurements obtained by a visible ground-based spectrometer and PSCs have been studied over the Belgrano II Antarctic station for years 2018 and 2019. The methodology applied has been validated by full spherical radiative transfer simulations, which confirm that PSCs can be detected and their altitude estimated with this instrumentation. Moreover, our investigation shows that this method is useful even in presence of optically thin tropospheric clouds or aerosols. PSCs observed in this work have been classified by altitude. Our results are in good agreement with the stratospheric temperature evolution obtained by the global meteorological model ECMWF (European Centre for Medium Range Weather Forecasts) and with satellite PSCs observations from CALIPSO (Cloud-Aerosol-Lidar and Infrared Pathfinder Satellite Observations). To investigate the presence and long-term evolution of PSCs, the methodology used in this work could also be applied to foreseen and/or historical observations obtained with ground-based spectrometers such e. g. those dedicated to Differential Optical Absorption Spectroscopy (DOAS) for trace gas observation in Arctic and Antarctic sites.
Published: 2021
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20. Development of mouse models of angiosarcoma driven by p53

Author: Donald M. Salter, Meredyth Griffin, Morwenna Muir, Katy Teo, Jayne Culley, James R. Smith, Laura Gomez-Cuadrado, Kylie Matchett, Andrew H. Sims, Larry Hayward, Neil C. Henderson, and Valerie G. Brunton
Subjects: Angiosarcoma, Trp53, Genetically engineered mouse model, Lymphomas, Tumour, Medicine, Pathology, RB1-214
Abstract: Angiosarcomas are a rare group of tumours which have poor prognosis and limited treatment options. The development of new therapies has been hampered by a lack of good preclinical models. Here, we describe the development of an autochthonous mouse model of angiosarcoma driven by loss of p53 in VE-cadherin-expressing endothelial cells. Using Cdh5-Cre to drive recombination in adult endothelial cells, mice developed angiosarcomas with 100% penetrance upon homozygous deletion of Trp53 with a median lifespan of 325 days. In contrast, expression of the R172H mutant p53 resulted in formation of thymic lymphomas with a more rapid onset (median lifespan 151 days). We also used Pdgfrb-Cre-expressing mice, allowing us to target predominantly pericytes, as these have been reported as the cell of origin for a number of soft tissue sarcomas. Pdgfrb-Cre also results in low levels of recombination in venous blood endothelial cells in multiple tissues during development. Upon deletion of Trp53 in Pdgfrb-Cre-expressing mice (Pdgfrb-Cre, Trp53fl/fl mice), 65% developed lymphomas and 21% developed pleomorphic undifferentiated soft tissue sarcomas. None developed angiosarcomas. In contrast, 75% of Pdgfrb-Cre, Trp53R172H/R172H mice developed angiosarcomas, with 60% of these mice also developing lymphomas. The median lifespan of the Pdgfrb-Cre, Trp53R172H/R172H mice was 151 days. Re-implantation of angiosarcoma tumour fragments from Cdh5-Cre, Trp53fl/fl mice provided a more consistent and rapid model of angiosarcoma than the two spontaneous models. The ability to passage tumour fragments through the mouse provides a novel model which is amenable to preclinical studies and will help the development of potential new therapies for angiosarcoma.
Published: 2019
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21. Use of a genetically engineered mouse model as a preclinical tool for HER2 breast cancer

Author: Helen Creedon, Lucy A. Balderstone, Morwenna Muir, Jozef Balla, Laura Gomez-Cuadrado, Natasha Tracey, Joseph Loane, Teresa Klinowska, William J. Muller, and Valerie G. Brunton
Subjects: HER2, Breast cancer, Resistance, Epithelial-to-mesenchymal transition, Medicine, Pathology, RB1-214
Abstract: Resistance to human epidermal growth factor receptor 2 (HER2)-targeted therapies presents a major clinical problem. Although preclinical studies have identified a number of possible mechanisms, clinical validation has been difficult. This is most likely to reflect the reliance on cell-line models that do not recapitulate the complexity and heterogeneity seen in human tumours. Here, we show the utility of a genetically engineered mouse model of HER2-driven breast cancer (MMTV-NIC) to define mechanisms of resistance to the pan-HER family inhibitor AZD8931. Genetic manipulation of MMTV-NIC mice demonstrated that loss of phosphatase and tensin homologue (PTEN) conferred de novo resistance to AZD8931, and a tumour fragment transplantation model was established to assess mechanisms of acquired resistance. Using this approach, 50% of tumours developed resistance to AZD8931. Analysis of the resistant tumours showed two distinct patterns of resistance: tumours in which reduced membranous HER2 expression was associated with an epithelial-to-mesenchymal transition (EMT) and resistant tumours that retained HER2 expression and an epithelial morphology. The plasticity of the EMT phenotype was demonstrated upon re-implantation of resistant tumours that then showed a mixed epithelial and mesenchymal phenotype. Further AZD8931 treatment resulted in the generation of secondary resistant tumours that again had either undergone EMT or retained their original epithelial morphology. The data provide a strong rationale for basing therapeutic decisions on the biology of the individual resistant tumour, which can be very different from that of the primary tumour and will be specific to individual patients.
Published: 2016
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22. Ecological and reproductive aspects of Aparasphenodon brunoi (Anura: Hylidae) in an ombrophilous forest area of the Atlantic Rainforest Biome, Brazil

Author: Laura Gomez-Mesa, Juliane Pereira-Ribeiro, Atilla C. Ferreguetti, Marlon Almeida-Santos, Helena G. Bergallo, and Carlos F. D. Rocha
Subjects: Casque-headed frog, ecological aspects, ecology, habitat use, Zoology, QL1-991
Abstract: ABSTRACT Presented is the first information on the ecological and reproductive aspects of the treefrog, Aparasphenodon brunoi Miranda-Ribeiro, 1920, living in ombrophilous forest areas of the Atlantic Rainforest, Brazil. We recorded the species’ daily activity and over the course of a year, population density during the year, microhabitat usage, diet, and some reproductive features (quantity, diameter and mean mass of oocytes, mean reproductive effort of female). Field sampling was conducted monthly from June 2015 to July 2016. Searches for treefrogs were systematic, using visual encounter surveys along 14 plots RAPELD long term research modules established in the forest. For each captured individual, we recorded the hour, microhabitat used, and perch height. The diet of the population was ascertained based on 15 individuals collected outside the study plot areas. Treefrogs used seven different types of microhabitats in the forest but the preferred microhabitats were tree-trunks and lianas. The amount of accumulated rainfall and air temperature interacted to explain the number of A. brunoi individuals active throughout the year. The reproductive strategy for females of this comparatively large arboreal frog in the ombrophilous forest is to produce clutches with a large number (900.8 ± 358.1) of relatively small-sized eggs. We conclude that in the ombrophious forest of the Vale Natural Reserve, A. brunoi is a nocturnal arboreal treefrog active throughout the year but activity increases during the wet season as a result of increased precipitation. In the forest, treefrogs tend to perch mainly on tree-trunks and lianas about 1 m above ground, where it feeds preferably on relatively large bodied arthropod prey. When living in the ombrophilous forest of the Atlantic rainforest, A. brunoi may change some features of its ecology (e.g. marked difference in the use of bromeliads) compared to when living in restinga habitats.
Published: 2017
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23. Ratings and experiences in using a mobile application to increase physical activity among university students: implications for future design.

Author: Caroline A. Figueroa, Laura Gomez-Pathak, Imran Khan, Joseph Jay Williams, Courtney R. Lyles, and Adrián Aguilera
Published: 2024
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24. Analysis of the Legionella longbeachae genome and transcriptome uncovers unique strategies to cause Legionnaires' disease.

Author: Christel Cazalet, Laura Gomez-Valero, Christophe Rusniok, Mariella Lomma, Delphine Dervins-Ravault, Hayley J Newton, Fiona M Sansom, Sophie Jarraud, Nora Zidane, Laurence Ma, Christiane Bouchier, Jerôme Etienne, Elizabeth L Hartland, and Carmen Buchrieser
Subjects: Genetics, QH426-470
Abstract: Legionella pneumophila and L. longbeachae are two species of a large genus of bacteria that are ubiquitous in nature. L. pneumophila is mainly found in natural and artificial water circuits while L. longbeachae is mainly present in soil. Under the appropriate conditions both species are human pathogens, capable of causing a severe form of pneumonia termed Legionnaires' disease. Here we report the sequencing and analysis of four L. longbeachae genomes, one complete genome sequence of L. longbeachae strain NSW150 serogroup (Sg) 1, and three draft genome sequences another belonging to Sg1 and two to Sg2. The genome organization and gene content of the four L. longbeachae genomes are highly conserved, indicating strong pressure for niche adaptation. Analysis and comparison of L. longbeachae strain NSW150 with L. pneumophila revealed common but also unexpected features specific to this pathogen. The interaction with host cells shows distinct features from L. pneumophila, as L. longbeachae possesses a unique repertoire of putative Dot/Icm type IV secretion system substrates, eukaryotic-like and eukaryotic domain proteins, and encodes additional secretion systems. However, analysis of the ability of a dotA mutant of L. longbeachae NSW150 to replicate in the Acanthamoeba castellanii and in a mouse lung infection model showed that the Dot/Icm type IV secretion system is also essential for the virulence of L. longbeachae. In contrast to L. pneumophila, L. longbeachae does not encode flagella, thereby providing a possible explanation for differences in mouse susceptibility to infection between the two pathogens. Furthermore, transcriptome analysis revealed that L. longbeachae has a less pronounced biphasic life cycle as compared to L. pneumophila, and genome analysis and electron microscopy suggested that L. longbeachae is encapsulated. These species-specific differences may account for the different environmental niches and disease epidemiology of these two Legionella species.
Published: 2010
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25. Repurposing rapid diagnostic tests to detect falsified vaccines in supply chains

Author: Bharucha, Tehmina, Gangadharan, Bevin, Clarke, Rebecca, Fernandez, Laura Gomez, Arman, Benediktus Yohan, Walsby-Tickle, John, Deats, Michael, Mosca, Sara, Lin, Qianqi, Stokes, Robert, Dunachie, Susanna, Merchant, Hamid A., Dubot-Pérès, Audrey, Caillet, Céline, McCullagh, James, Matousek, Pavel, Zitzmann, Nicole, and Newton, Paul N.
Published: 2024
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26. Innovative method for rapid detection of falsified COVID-19 vaccines through unopened vials using handheld Spatially Offset Raman Spectroscopy (SORS)

Author: Mosca, Sara, Lin, Qianqi, Stokes, Robert, Bharucha, Tehmina, Gangadharan, Bevin, Clarke, Rebecca, Fernandez, Laura Gomez, Deats, Michael, Walsby-Tickle, John, Arman, Benediktus Yohan, Chunekar, Shrikrishna R., Patil, Kundan D., Gairola, Sunil, Van Assche, Kerlijn, Dunachie, Susanna, Merchant, Hamid A., Kuwana, Rutendo, Maes, Alexandrine, McCullagh, James, Caillet, Céline, Zitzmann, Nicole, Newton, Paul N., and Matousek, Pavel
Published: 2023
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27. APUNTES CONSTITUCIONALES SOBRE EL PIN PARENTAL

Author: ABEJA, LAURA GÓMEZ
Published: 2022

28. Experience With the Use of Baricitinib and Tocilizumab Monotherapy or Combined, in Patients With Interstitial Pneumonia Secondary to Coronavirus COVID19: A Real-World Study

Author: Rosas, José, Liaño, Francisco Pasquau, Cantó, Mónica Llombart, Barea, José María Carrasco, Beser, Amparo Raga, Rabasa, José Tomás Algado, Adsuar, Francisco Martínez, Auli, Brian Vila, López, Isabel Fernández, Sainz, Ana María Garijo, Ramis, Pere Esquerdo, Pérez, Laura Ruiz, Rebollo, Mª Luisa Navarrete, Lorido, Raquel Hernández, and Escolar, Laura Gómez
Published: 2022
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29. NEOTROPICAL CARNIVORES : a data set on carnivore distribution in the Neotropics

Author: Nagy-Reis, Mariana B., de Faria Oshima, Júlia Emi, Kanda, Claudia Zukeran, Palmeira, Francesca Belem Lopes, de Melo, Fabiano Rodrigues, Morato, Ronaldo Gonçalves, Bonjorne, Lilian, Magioli, Marcelo, Leuchtenberger, Caroline, Rohe, Fabio, Lemos, Frederico Gemesio, Martello, Felipe, Alves-Eigenheer, Milene, da Silva, Rafaela Aparecida, dos Santos, Juliana Silveira, Priante, Camila Fátima, Bernardo, Rodrigo, Rogeri, Patricia, Assis, Julia Camara, Gaspar, Lucas Pacciullio, Tonetti, Vinicius Rodrigues, Trinca, Cristiano Trapé, de Souza Ribeiro, Adauto, Bocchiglieri, Adriana, Hass, Adriani, Canteri, Adriano, Chiarello, Adriano Garcia, Paglia, Adriano Pereira, Pereira, Adriele Aparecida, de Souza, Agnis Cristiane, Gatica, Ailin, Medeiro, Akyllam Zoppi, Eriksson, Alan, Costa, Alan Nilo, González-Gallina, Alberto, Yanosky, Alberto A., de la Cruz, Alejandro Jesus, Bertassoni, Alessandra, Bager, Alex, Bovo, Alex Augusto Abreu, Mol, Alexandra Cravino, Bezerra, Alexandra Maria Ramos, Percequillo, Alexandre, Vogliotti, Alexandre, Lopes, Alexandre Martins Costa, Keuroghlian, Alexine, Hartley, Alfonso Christopher Zúñiga, Devlin, Allison L., de Paula, Almir, García-Olaechea, Alvaro, Sánchez, Amadeo, Aquino, Ana Carla Medeiros Morato, Srbek-Araujo, Ana Carolina, Ochoa, Ana Cecilia, Tomazzoni, Ana Cristina, Lacerda, Ana Cristyna Reis, de Faria Bacellar, Ana Elisa, Campelo, Ana Kellen Nogueira, Victoria, Ana María Herrera, de Oliveira Paschoal, Ana Maria, Potrich, Ana Paula, Gomes, Ana Paula Nascimento, Olímpio, Ana Priscila Medeiros, Costa, Ana Raissa Cunha, de Almeida Jácomo, Anah Tereza, Calaça, Analice Maria, Jesus, Anamélia Souza, de Barros Barban, Ananda, Feijó, Anderson, Pagoto, Anderson, Rolim, Anderson Claudino, Hermann, Andiara Paula, de Castro e Souza, Andiara Silos Moraes, Alonso, André Chein, Monteiro, André, Mendonça, André Faria, Luza, André Luís, Moura, André Luis Botelho, da Silva, André Luiz Ferreira, Lanna, Andre Monnerat, Antunes, Andre Pinassi, Nunes, André Valle, Dechner, Andrea, Carvalho, Andrea Siqueira, Novaro, Andres Jose, Scabin, Andressa Barbara, Gatti, Andressa, Nobre, Andrezza Bellotto, Montanarin, Anelise, Deffaci, Ângela Camila, de Albuquerque, Anna Carolina Figueiredo, Mangione, Antonio Marcelo, Pinto, Antonio Millas Silva, Pontes, Antonio Rossano Mendes, Bertoldi, Ariane Teixeira, Calouro, Armando Muniz, Fernandes, Arthur, Ferreira, Arystene Nicodemo, Ferreguetti, Atilla Colombo, Rosa, Augusto Lisboa Martins, Banhos, Aureo, da Silva de Souza Francisco, Beatriz, Cezila, Beatriz Azevedo, de Mello Beisiegel, Beatriz, de Thoisy, Benoit, Ingberman, Bianca, dos Santos Neves, Bianca, Pereira-Silva, Brenda, de Camargo, Bruna Bertagni, da Silva Andrade, Bruna, Santos, Bruna Silva, Leles, Bruno, Campos, Bruno Augusto Torres Parahyba, Kubiak, Bruno Busnello, de Albuquerque França, Bruno Rodrigo, Saranholi, Bruno Henrique, Mendes, Calebe Pereira, Devids, Camila Cantagallo, Pianca, Camila, Rodrigues, Camila, Islas, Camila Alvez, de Lima, Camilla Angélica, de Lima, Camilo Ribeiro, Gestich, Carla Cristina, Tedesco, Carla Denise, De Angelo, Carlos, Fonseca, Carlos, Hass, Carlos, Peres, Carlos A., Kasper, Carlos Benhur, Durigan, Carlos Cesar, Fragoso, Carlos Eduardo, Verona, Carlos Eduardo, Rocha, Carlos Frederico Duarte, Salvador, Carlos Henrique, Vieira, Carlos Leonardo, Ruiz, Carmen Elena Barragán, Cheida, Carolina Carvalho, Sartor, Caroline Charão, da Costa Espinosa, Caroline, Fieker, Carolline Zatta, Braga, Caryne, Sánchez-Lalinde, Catalina, Machado, Cauanne Iglesias Campos, Cronemberger, Cecilia, Luna, Cecília Licarião, Del Vechio, Christine, Bernardo, Christine Steiner S., Hurtado, Cindy Meliza, Lopes, Cíntia M., da Rosa, Clarissa Alves, Cinta, Claudia Cristina, Costa, Claudia Guimaraes, Zárate-Castañeda, Claudia Paola, Novaes, Claudio Leite, Jenkins, Clinton N., Seixas, Cristiana Simão, Martin, Cristiane, Zaniratto, Cristiane Patrícia, López-Fuerte, Cristina Fabiola, da Cunha, Cristina Jaques, De-Carvalho, Crizanto Brito, Chávez, Cuauhtémoc, Santos, Cyntia Cavalcante, Polli, Daiana Jeronimo, Buscariol, Daiane, Carreira, Daiane Cristina, Galiano, Daniel, Thornton, Daniel, da Silva Ferraz, Daniel, Lamattina, Daniela, Moreno, Daniele Janina, Moreira, Danielle Oliveira, Farias, Danilo Augusto, Barros-Battesti, Darci Moraes, Tavares, Davi Castro, Braga, David Costa, Gaspar, Denise Alemar, Friedeberg, Diana, Astúa, Diego, Silva, Diego Afonso, Viana, Diego Carvalho, Lizcano, Diego J., Varela, Diego M., Loretto, Diogo, Gräbin, Diogo Maia, Eaton, Donald P., da Silva, Douglas Machado, de Matos Dias, Douglas, Camara, Edeltrudes Maria Valadares Calaça, Barbier, Eder, Chávez-González, Edgar, Rocha, Ednaldo Cândido, de Souza Lima, Edson, Carrano, Eduardo, Eizirik, Eduardo, Nakano-Oliveira, Eduardo, Rigacci, Eduardo Delgado, Santos, Eduardo Marques, Venticinque, Eduardo Martins, Alexandrino, Eduardo Roberto, Ribeiro, Edvandro Abreu, Setz, Eleonore, Rocha, Eliana César Laranjeira Duarte, Carvalho, Elildo Alves Ribeiro, Rechenberg, Elisabete, da Costa Fraga, Elmary, Mendonça, Eloisa Neves, D’Bastiani, Elvira, Isasi-Catalá, Emiliana, Guijosa-Guadarrama, Emiliano, Ramalho, Emiliano Esterci, González, Enrique, Hasui, Érica, Saito, Erica Naomi, Fischer, Erich, Aguiar, Erick Francisco, Rocha, Erick Sekiama, Nambo, Erik Daniel Martínez, de la Peña-Cuéllar, Erika, Castro, Érika Paula, de Freitas, Evellyn Borges, Pedó, Ezequiel, Rocha, Fabiana Lopes, Girardi, Fabiane, de Aguiar Pereira, Fabiane, Soares, Fábio Angelo Melo, de Oliveira Roque, Fabio, Díaz-Santos, Fabio Gabriel, Patiu, Fabio Mello, do Nascimento, Fabio Oliveira, Ferreira, Fabíola Keesen, Diaz-Santos, Fabricio, Fantacini, Felipe Moreli, Pedrosa, Felipe, da Silva, Felipe Pessoa, Velez-Garcia, Felipe, Gomes, Felipe Bittioli R., da Silva, Fernanda Guedes, Michalski, Fernanda, de Azevedo, Fernanda Cavalcanti, de Barros, Fernanda Cristina, da Silva Santos, Fernanda, Abra, Fernanda Delborgo, do Passo Ramalho, Fernanda, Hatano, Fernanda Martins, Anaguano-Yancha, Fernando, Gonçalves, Fernando, Pedroni, Fernando, Passos, Fernando C., de Castro Jacinavicius, Fernando, m, Fernando César Gonçalves Bonfi, Puertas, Fernando Henrique, Contreras-Moreno, Fernando M., Tortato, Fernando Rodrigo, Santos, Filipe Martins, Chaves, Flávia Guimarães, Tirelli, Flavia Pereira, Boas, Flávio Eduardo Vilas, Rodrigues, Flavio Henrique Guimarães, Ubaid, Flávio Kulaif, Grotta-Neto, Francisco, Palomares, Francisco, Souza, Franco Leandro, Costa, Francys Emanuelle, França, Frederico G. R., Pinto, Fredy Ramírez, Aguiar, Gabriel Lima, Hofmann, Gabriel Selbach, Heliodoro, Gabriela, Duarte, Gabriela Teixeira, de Andrade, Gabrielle Ribeiro, Beca, Gabrielle, Zapata-Ríos, Galo, Giné, Gastón Andrés Fernandez, Powell, George V. N., Fernandes, Geraldo Wilson, Forero-Medina, German, Melo, Geruza L., Santana, Gindomar Gomes, Ciocheti, Giordano, Alves, Giselle Bastos, de Oliveira Souto, Glauber Henrique Borges, Villarroel, Glenda Jéssica, de Oliveira Porfirio, Grasiela Edith, Batista, Graziele Oliveira, Behling, Greici Maia, Crespo, Guido Marcos Ayala, de Miranda Mourão, Guilherme, Rezende, Guilherme Zamarian, da Costa Toledo, Gustavo Alves, Herrera, Heitor Miraglia, Prado, Helena Alves, de Godoy Bergallo, Helena, Secco, Helio, Rajão, Henrique, Roig, Henrique Llacer, Concone, Henrique Villas Boas, Duarte, Herbert, Ermenegildo, Hiago, Neto, Hipólito Ferreira Paulino, Quigley, Howard, Lemos, Hudson Macedo, Cabral, Hugo, Fernandes-Ferreira, Hugo, del Castillo, Hugo Fernando, Ribeiro, Igor Kintopp, Coelho, Igor Pfeifer, Franceschi, Ingridi Camboim, Melo, Isabel, Oliveira-Bevan, Isabella, Mourthe, Italo, Bernardi, Itiberê, de la Torre, J. Antonio, Marinho-Filho, Jader, Martinez, Jaime, Perez, Jaime Xavier Palacios, Pérez-Torres, Jairo, Bubadué, Jamile, Silveira, Jana Rangel, Seibert, Jardel Brandão, Oliveira, Jasmim Felipe, Assis, Jasmine Resende, De la Maza, Javier, Hinojosa, Javier, Metzger, Jean Paul, Thompson, Jeff rey James, Svenning, Jens-Christian, Gouvea, Jéssica Abonizio, Souza, Jesus Rodrigues Domingos, Pincheira-Ulbrich, Jimmy, Nodari, Joana Zorzal, Miranda, João, Gebin, João Carlos Zecchini, Giovanelli, João Gabriel Ribeiro, Junior, João Luiz Rossi, Favoretti, João Paulo Pandini, Villani, João Paulo, Just, João Paulo Gava, Souza-Alves, João Pedro, Costa, Jociel Ferreira, Rocha, Joedison, Polisar, John, Sponchiado, Jonas, Cherem, Jorge José, Marinho, Jorge Reppold, Ziegler, Jörn, Cordeiro, José, de Sousa e Silva Júnior, José, Rodriguez-Pulido, Jose Ariel, dos Santos, José Carlos Chaves, dos Reis Júnior, José Clemensou, Mantovani, Jose Eduardo, Ramírez, José Fernando Moreira, Sarasola, José Hernán, Cartes, Jose Luis, Duarte, José Maurício Barbanti, Longo, Jose Milton, Dantas, José Oliveira, Venancio, José Otávio, de Matos, Jose Roberto, Pires, José Salatiel Rodrigues, Hawes, Joseph E., Santos, Joyce Gonçalves, Ruiz-Esparza, Juan, Lanfranco, Juan Andrés Martínez, Rudolf, Juan Carlos, Charre-Medellin, Juan Felipe, Zanón-Martínez, Juan Ignacio, Peña-Mondragón, Juan L., Krauer, Juan Manuel Campos, Arrabal, Juan Pablo, Beduschi, Julia, Ilha, Júlia, Mata, Julia Carolina, Bonanomi, Juliana, Jordao, Juliana, de Almeida-Rocha, Juliana Monteiro, Pereira-Ribeiro, Juliane, Zanoni, Juliani Bruna, Bogoni, Juliano André, Pacheco, Julio Javier Chacón, Palma, Kamila Marianne Contreras, Strier, Karen B., Castro, Karen Giselle Rodriguez, Didier, Karl, Schuchmann, Karl L., Chávez-Congrains, Karla, Burs, Kathrin, Ferraz, Katia M. P. M. B., Juarez, Keila Macfadem, Flesher, Kevin, Morais, Kimberly Danielle Rodrigues, Lautenschlager, Laís, Grossel, Laís Aline, Dahmer, Lais Camila, de Almeida, Lana Resende, Fornitano, Larissa, de Nazaré Barros Barbosa, Larissa, Bailey, Larissa L., Barreto, Larissa Nascimento, Villalba, Laura Magnolia, Magalhães, Laura Martins, Cullen, Laury, Marques, Leandro, Costa, Leonardo Marques, Silveira, Leandro, Moreira, Leandro Santana, Sartorello, Leonardo, de Carvalho Oliveira, Leonardo, de Paula Gomes, Leonardo, dos Santos Aguiar, Leonardo, da Silva, Leonardo Henrique, Mendonça, Leonardo Siqueira, Valenzuela, Leonor Adriana, Benavalli, Letícia, Dias, Leticia Coutinho Sangy, Munhoes, Leticia Prado, Catenacci, Lilian, Rampim, Lilian Elaine, de Paula, Lívia Maria, Nascimento, Lorena Anne, da Silva, Lucas Gonçalves, Quintilham, Lucas, Segura, Lucas Ramis, Perillo, Lucas Neves, Rezende, Lucas Rodrigo, Retta, Lucía Martínez, Rojas, Lucia Nathaly Stefany, Guimarães, Luiza Neves, Araújo, Luciana, da Silva, Luciana Zago, de Alagão Querido, Luciano Carramaschi, Verdade, Luciano Martins, Perera-Romero, Lucy E., Carvalho-Leite, Ludimila Juliele, Hufnagel, Ludmila, Bernardo, Luis Renato Rezende, Oliveira, Luiz Flamarion, Santos, Luiz Gustavo Rodrigues Oliveira, Lyra, Luiz Henrique, Borges, Luiz Henrique Medeiros, Severo, Magnus Machado, Benchimol, Maíra, Quatrocchi, Maira Giuliana, Martins, Maísa Ziviani Alves, Rodrigues, Manoel, Penteado, Marcel José Franco, Moraes, Marcela Figuerêdo Duarte, Oliveira, Marcela Alvares, Lima, Marcela Guimarães Moreira, do Carmo Pônzio, Marcella, Cervini, Marcelo, da Silva, Marcelo, Passamani, Marcelo, Villegas, Marcelo Alejandro, dos Santos Junior, Marcelo Augusto, Yamane, Marcelo Hideki, de Assis Jardim, Marcia Maria, de Oliveira, Márcio Leite, Silveira, Marcos, Tortato, Marcos Adriano, de Souza Lima Figueiredo, Marcos, Vieira, Marcus Vinícius, Sekiama, Margareth L., da Silva, Maria Augusta Andrade, Nuñez, María Beatriz, Siviero, Maria Brunini, Carrizo, María Celina, Barros, Maria Claudene, Barros, Marília A. S., do Rosário, Maria Cristina Ferreira, Mora, María Cristina Peñuela, del Carmen Fleytas Jover, Maria, de Freitas Morandi, Maria Elisa, Huerta, Maria Emilia, Fernandes, Maria Emília Avelar, Siñani, Maria Estela Viscarra, Iezzi, María Eugenia, Pereira, Maria João Ramos, Vinassa, Maria Laura Gomez, Lorini, Maria Lucia, Jorge, Maria Luisa S. P., Morini, Maria Santina, Guenther, Mariana, Landis, Mariana Bueno, Vale, Mariana M., Xavier, Mariana Sampaio, Tavares, Mariana Silva, Kaizer, Mariane, Velilla, Marianela, Bergel, Mariano Maudet, Hartmann, Marilia Teresinha, da Silva, Marina Lima, Rivero, Marina, Munerato, Marina Salles, da Silva, Marina Xavier, Zanin, Marina, Marques, Marinêz Isaac, Haberfeld, Mario, Di Bitetti, Mario S., Bowler, Mark, Galliez, Maron, Ortiz-Moreno, Martha Lucia, Buschiazzo, Martin, Montes, Martin Alejandro, Alvarez, Martín R., Melo-Dias, Mateus, Reis, Matheus Gonçalves, Corrêa, Matheus Rocha Jorge, Tobler, Mathias W., Gompper, Matthew E., Nunez-Regueiro, Mauricio, Vecchi, Maurício Brandão, Graipel, Maurício Eduardo, Godoi, Mauricio Neves, Moura, Mauricio O., Konzen, Maurício Quoos, Pardo, Maximiliano Víctor, Beltrão, Mayara Guimarães, Mongelli, Melissa, Almeida, Meyline Oliveira, Gilmore, Michael P., Schutte, Michel, Faria, Michel Barros, Luiz, Micheli Ribeiro, de Paula, Milton, Hidalgo-Mihart, Mircea G., Perilli, Miriam Lucia Lages, Freitas-Junior, Mozart Caetano, da Silva, Murillo Prado, Denkiewicz, Natalia Mariana, Torres, Natalia Mundim, ers, Natalie Olifi, Da Silva De Lima, Natani, de Albuquerque, Natasha Moraes, Canassa, Nathália Fernandes, de Almeida Curi, Nelson Henrique, Prestes, Nêmora Pauletti, Falconi, Nereyda, Gurgel-Filho, Newton Mota, Pasqualotto, Nielson, Cáceres, Nilton C., Peroni, Nivaldo, de la Sancha, Noé U., Zanella, Noeli, Monroy-Vilchis, Octavio, Pays, Olivier, Arimoro, Omolabake Alhambra, Ribeiro, Otávio Santi, Villalva, Pablo, Gonçalves, Pablo Rodrigues, Santos, Paloma Marques, Brennand, Pamella, Rocha, Patrício, Akkawi, Paula, Cruz, Paula, Ferreira, Paula Modenesi, Prist, Paula Ribeiro, Martin, Paula Sanches, Arroyo-Gerala, Paulina, Auricchio, Paulo, Hartmann, Paulo Afonso, de Tarso Zuquim Antas, Paulo, Camargo, Paulo H. S. A., Marinho, Paulo Henrique, ino, Paulo Henrique Peira Ruff, Prado, Paulo Inácio, Martins, Paulo Wesley, Cordeiro-Estrela, Pedro, Luna, Pedro, Sarmento, Pedro, Peres, Pedro Henrique Faria, Galetti, Pedro Manoel, de Castilho, Pedro Volkmer, Renaud, Pierre-Cyril, Scarascia, Pietro Oliveira, De Paula Andrade Cobra, Priscilla, Lombardi, Pryscilla Moura, Bessa, Rafael, Reyna-Hurtado, Rafael, de Souza, Rafael Cerqueira Castro, Hoogesteijn, Rafael Jan, Alves, Rafael Souza Cruz, Romagna, Rafael Spilere, Silva, Ramon Lima, de Oliveira, Ramonna, Beltrão-Mendes, Raone, de Macêdo Alencar, Raony, Coutinho, Raphaella, da Silva, Raquel Costa, Grando, Raquel L. S. C. Caribé, Matos, Rayanne Gama, da Silva Araujo, Raylenne, Pedroso, Rayssa Faria, Durães, Rayssa Mainette Nantes, Ribeiro, Renan Lieto Alves, Chagas, Renata, Miotto, Renata, Bonikowski, Renata Twardowsky Ramalho, Muylaert, Renata Lara, Pagotto, Renata Valls, Hilário, Renato Richard, Faria, Rhayssa Terra, Bassini-Silva, Ricardo, Sampaio, Ricardo, Sartorello, Ricardo, Pires, Ricardo Araújo, Hatakeyama, Richard, de Cassia Bianchi, Rita, Buitenwerf, Robert, Wallace, Robert, Paolino, Roberta Montanheiro, Fusco-Costa, Roberto, Trovati, Roberto Guilherme, Tomasi, Roberto Junior, Hack, Robson Odeli Espíndola, Magalhães, Rodolfo Assis, de Albuquerque Nobrega, Rodrigo Affonso, de Almeida Nobre, Rodrigo, Massara, Rodrigo Lima, Fróes, Rodrigo Medina, da Cunha Araújo, Rodrigo Paulo, Pérez, Rodrigo Raúl León, Jorge, Rodrigo Silva Pinto, de Paula, Rogério Cunha, Martins, Rogério, da Cunha, Rogério Grassetto Teixeira, Costa, Rômulo, Alves, Romulo Romeu Nobrega, Garcia-Anleu, Rony, Almeida, Rony Peterson Santos, Loachamín, Rubén Darío Cueva, Andrade, Rúbia Santana, Juárez, Rugieri, Bordallo, Samanta Uchôa, Guaragni, Samara Arsego, Carrillo-Percastegui, Samia E., Seber, Samile, Astete, Samuel, Hartz, Sandra Maria, Espinosa, Santiago, Solas, Sara Álvarez, Lima, Saulo Ramos, Silvestre, Saulo Meneses, de Souza Machado, Sávio Augusto, Keuroghlian-Eaton, Sean, Albanesi, Sebastian, Costa, Sebastián Andrés, Bazilio, Sergio, Mendes, Sergio Lucena, Althoff, Sérgio Luiz, Pinheiro, Shery Duque, Napiwoski, Silvio Junior, Ramirez, Sixto Fernández, Talamoni, Sonia Aparecida, Age, Stefani Gabrieli, Pereira, Taiguã Corrêa, Moreira, Tainah Cruz, Trigo, Tatiane Campos, da Silva Gondim, Tayana Mendonça, Karlovic, Thamíris Christina, Cavalcante, Thiago, Maccarini, Thiago, Rodrigues, Thiago Ferreira, de Camargo e Timo, Thiago Philipe, Monterrubio, Tiberio Cesar, Piovezan, Ubiratan, Cavarzere, Vagner, Towns, Valeria, Onofrio, Valeria Castilho, Oliveira, Valeska Buchemi, Araújo, Valquíria Cabral, Melo, Vanessa Lazaro, Kanaan, Vanessa Tavares, Iwakami, Victor, Vale, Victor, Filho, Vilmar Picinatto, Alberici, Vinicius, Bastazini, Vinicius A. G., Orsini, Vinícius Santana, da Silva Braz, Vivian, Bonzi, Viviana B. Rojas, Layme, Viviane Maria Guedes, Gaboardi, Viviane Telles Rodrigues, Rocha, Vlamir José, Martins, Waldney Pereira, Tomas, Walfrido Moraes, Hannibal, Wellington, Dáttilo, Wesley, Silva, Wesley R., Endo, Whaldener, Bercê, William, de la Cruz, Yaribeth Bravata, Ribeiro, Yuri Geraldo Gomes, Galetti, Mauro, and Ribeiro, Milton C.
Published: 2020

30. The Evolution from the Environmental Education Model to the Education for Sustainable Development Model. Case Study of Environmental Engineering at Santo Tomas University, Colombia.

Author: Pedro Mauricio Acosta Castellanos, Araceli Queiruga Dios, Laura Gomez Araque, and Paula Rojas Ramos
Published: 2020
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31. Preventing Omission of Key Evidence Fallacy in Process-Based Argumentations.

Author: Faiz Ul Muram, Barbara Gallina, and Laura Gomez Rodriguez
Published: 2018
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32. Electrosprayed chitosan microcapsules as delivery vehicles for vaginal phytoformulations

Author: Moreno, María Alejandra, Gómez-Mascaraque, Laura Gómez, Arias, Myriam, Zampini, Iris Catiana, Sayago, Jorge Esteban, Ramos, Liudis Leidy Pino, Schmeda-Hirschmann, Guillermo, López-Rubio, Amparo, and Isla, María Inés
Published: 2018
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33. Structural controls of the migration of mantle-derived CO2 offshore in the Santos Basin (Southeastern Brazil).

Author: Belotto Plawiak, Rafael Andre, Carvalho, Marcelo Jose, Sombra, Cristiano Leite, Brandao, Davy Raeder, Mepen, Michelle, Ferrari, Andre Luiz, Pierantoni Gamboa, Luiz Antonio, de la Pena, Laura Gomez, and Todaro, Simona
Subjects: IMMIGRATION enforcement, MOHOROVICIC discontinuity, CARBONATE reservoirs, MULTISCALE modeling, CONCEPTUAL models, CONTINENTAL crust, EARTH'S mantle
Abstract: We present a multi-scale conceptual model based on structural controls of the migration of mantle-derived CO2 offshore in the Santos Basin (Southeastern Brazil). We assembled the model from a regional 2D seismic reflection line integrated with potential gravimetric field data and a local 3D seismic reflection volume integrated with well data (lithologies and in situ stress). (i) The geochemical isotope range of 513CCO2 falls mostly within -7%" and -5%o and shows relatively high values for 3He/4He represented by an R/Ra rate of up to 5.60, indicating CO2 mantle generation and degassing. (ii) Seismic interpretation feasibly validated by potential gravimetric responses of the crustal structure (Moho discontinuity) show CO2 migration through deep-seated faults in a region of highly stretched continental crust with oceanward mantle uprising. (iii) Early Cretaceous basement highs generated in an obliquely syn-rift faulting system control CO2 accumulation in thermogenic travertines (hydrothermal carbonate reservoirs of continental lakes), and Aptian evaporites subsequently trap it. [ABSTRACT FROM AUTHOR]
Published: 2024
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34. P1569: HERPES ZOSTER VACCINATION IN HEMATOLOGY. A SINGLE CENTER EXPERIENCE.

Author: Rodriguez, Natalia De Las Heras, primary, Escalante, Fernando, additional, Campo, Laura Gomez del, additional, and Vidal, María Jesús, additional
Published: 2023
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35. The Power of Participatory Photography in ICTD Programs: Freedom to Explore beyond Images.

Author: Laura Gomez, Ricardo Gómez, and Sara Vannini
Published: 2017

36. Navigating Spaces for Political Action: Victories and Compromises for Mexico’s Local Organic Movement

Author: Nelson, Erin, Tovar, Laura Gómez, Knezevic, Irena, editor, Blay-Palmer, Alison, editor, Levkoe, Charles Z., editor, Mount, Phil, editor, and Nelson, Erin, editor
Published: 2017
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37. Kinematic analysis of secondary faults within a distributed shear-zone reveals fault linkage and increased seismic hazard

Author: Perea, Hector, Gràcia, Eulàlia, Martínez-Loriente, Sara, Bartolome, Rafael, de la Peña, Laura Gómez, de Mol, Ben, Moreno, Ximena, Iacono, Claudio Lo, Diez, Susana, Tello, Olvido, Gómez-Ballesteros, María, and Dañobeitia, Juan José
Published: 2018
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38. Macroeconomic Concerns and Intrastate Bargains: Explaining Illiberal Policies in Brazil's Automobile Sector

Author: Mera, Laura Gómez
Published: 2007

39. Effect of Thermoelectric Warming Therapy for the Treatment of Meibomian Gland Dysfunction

Author: MARIA-LAURA GOMEZ, NATALIE A. AFSHARI, DAISY D. GONZALEZ, and LINGYUN CHENG
Subjects: Ophthalmology, Tears, Humans, Meibomian Glands, Dry Eye Syndromes, Prospective Studies, Fluoresceins, Meibomian Gland Dysfunction, Retrospective Studies
Abstract: To evaluate the efficacy of thermoelectric warming therapy (MiBoFlo) in improving patient symptoms with standardized questionnaires and objective signs of meibomian gland dysfunction (MGD), which is an important underlying treatable factor in dry eye disease (DED), such as ocular surface staining, tear quality, and meibomian gland morphology. Multivariate analysis to identify predictors for the improvement in Ocular Surface Disease Index (OSDI) was also performed.Retrospective before-and-after study.A total of 203 eyes of 102 patients with DED were treated with MiBoFlo at the dry eye center. The OSDI and Standard Patient Evaluation of Eye Dryness (SPEED) questionnaires, best-corrected visual acuity, tear osmolarity, tear film breakup time (TBUT), corneal and conjunctival staining, meibography, number of glands expressing liquid, and quality of the improved meibum were assessed before and 6 months after MiBoFlo. Exclusion criteria included active ocular inflammation.Dry eye symptoms improved in the population, with both SPEED and OSDI lowering of dry eye symptoms by approximately 35% (P.001) at month 6. Significant improvements in lissamine green conjunctival staining, corneal fluorescein staining, TBUT, osmolarity, and secreting meibomian glands and meibum quality were also seen. Improvement was seen across all domains of the questionnaires and across all baseline parameters. Eyes with blepharitis and autoimmune disease improved less than average. No complications or adverse events occurred.MiBoFlo treatments produced clinical and statistically significant improvements in the signs and symptoms of MGD, irrespective of underlying ocular conditions. This improvement was sustained for the 6-month period of observation after initiating the treatment.
Published: 2022

40. Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Author: Global Health Research Unit on Global Surgery, National Institute for Health and Care Research, Adisa, Adewale, Bahrami-Hessari, Michael, Bhangu, Aneel, George, Christina, Ghosh, Dhruv, Glasbey, James, Haque, Parvez, Ingabire, J C Allen, Kamarajah, Sivesh Kathir, Kudrna, Laura, Ledda, Virginia, Li, Elizabeth, Lillywhite, Robert, Mittal, Rohin, Nepogodiev, Dmitri, Ntirenganya, Faustin, Picciochi, Maria, Simões, Joana Filipa Ferreira, Booth, L, Elliot, R, Kennerton, A S, Pettigrove, K L, Pinney, L, Richard, H, Tottman, R, Wheatstone, P, Wolfenden, John W D, Smith, A, Sayed, A Emad, Goswami, Aakansha Giri, Malik, Aamer, Mclean, Aaron Lawson, Hassan, Abbas, Nazimi, Abd Jabar, Aladna, Abdallah, Abdelgawad, Abdalrahman, Saed, Abdel, Abdelmageed, Abdelfatah, Ghannam, Abdelilah, Mahmoud, Abdelrahman, Alvi, Abdul, Ismail, Abdulaziz, Adesunkanmi, Abdulhafiz, Ebrahim, Abdulla, Al-Mallah, Abdullah, Alqallaf, Abdullah, Durrani, Abdullah, Gabr, Abdullah, Kirfi, Abdullahi Musa, Altaf, Abdulmalik, Almutairi, Abdulmjeed, Sabbagh, Abdulrahman J, Ajiya, Abdulrazak, Haddud, Abdurrahman, Alnsour, Abed Alfattah Mahmoud, Singh, Abhinav, Mittal, Abhishek, Semple, Abigail, Adeniran, Abiodun, Negussie, Abraham, Oladimeji, Abraham, Muhammad, Abubakar Bala, Yassin, Abubaker, Gungor, Abuzer, Tarsitano, Achille, Soibiharry, Adaiah, Dyas, Adam, Frankel, Adam, Peckham-Cooper, Adam, Truss, Adam, Issaka, Adamu, Ads, Adel Mohamed, Aderogba, Adeleke Akeem, Adeyeye, Ademola, Ademuyiwa, Adesoji, Sleem, Adham, Papa, Adrian, Cordova, Adriana, Appiah-Kubi, Adu, Meead, Adullah, Nacion, Aeris Jane D, Michael, Afieharo, Forneris, Agustin Albani, Duro, Agustin, Gonzalez, Agustin Rodriguez, Altouny, Ahmad, Ghazal, Ahmad, Khalifa, Ahmad, Ozair, Ahmad, Quzli, Ahmad, Haddad, Ahmad, Othman, Ahmad Faidzal, Yahaya, Ahmad Shuib, Elsherbiny, Ahmed, Nazer, Ahmed, Tarek, Ahmed, Abu-Zaid, Ahmed, Al-Nusairi, Ahmed, Azab, Ahmed, Elagili, Ahmed, Elkazaz, Ahmed, Kedwany, Ahmed, Nuhu, Ahmed Mohammed, Sakr, Ahmed, Shehta, Ahmed, Shirazi, Ahmed, Mohamed, Ahmed Mohamed Ibrahim, Sherif, Ahmed Elshawadfy, Awad, Ahmed K, Abbas, Ahmed M, Abdelrahman, Ahmed Saber, Ammar, Ahmed Siddique, Azzam, Ahmed Y, Ciftci, Ahmet Burak, Dural, Ahmet Cem, Sanli, Ahmet Necati, Rahy-Martín, Aida Cristina, Tantri, Aida Rosita, Khan, Aimal, Al-Touny, Aiman, Tariq, Aiman, Gmati, Aimen, Costas-Chavarri, Ainhoa, Auerkari, Aino, Landaluce-Olavarria, Aitor, Puri, Ajay, Radhakrishnan, Ajay, Ubom, Akaninyene Eseme, Pradhan, Akhilesh, Turna, Akif, Adepiti, Akinfolarin, Kuriyama, Akira, Kassam, Al-Faraaz, Hassouneh, Ala, El-Hussuna, Alaa, Habeebullah, Alaa, Ads, Alaa Mohamed, Mousli, Alaa, Biloslavo, Alan, Hoang, Alan, Kirk, Alan, Santini, Alasdair, Melero, Alba Vazquez, Calvache, Albaro José Nieto, Baduell, Albert, Chan, Albert, Abrate, Alberto, Balduzzi, Alberto, Sánchez, Alberto Cabañero, Navarrete-Peón, Alberto, Porcu, Alberto, Brolese, Alberto, Barranquero, Alberto G, Saibene, Alberto Maria, Adam, Albushra Altayeb, Vagge, Aldo, Maquilón, Alejandra Jara, Leon-Andrino, Alejandro, Sekulić, Aleksandar, Trifunovski, Aleksandar, Mako, Aleksandro, Bedada, Alemayehu Ginbo, Broglia, Alessandro, Coppola, Alessandro, Giani, Alessandro, Grandi, Alessandro, Iacomino, Alessandro, Moro, Alessandro, D’amico, Alessia, Malagnino, Alessia, Tang, Alethea, Doyle, Alex, Alfieri, Alex, Haynes, Alex, Wilkins, Alex, Baldwin, Alexander, Heriot, Alexander, Laird, Alexander, Lazarides, Alexander, O'connor, Alexander, Trulson, Alexander, Rokohl, Alexander Christopher, Caziuc, Alexandra, Triantafyllou, Alexandra, Anesi, Alexandre, Nikova, Alexandrina, Andrianakis, Alexandros, Charalabopoulos, Alexandros, Tsolakidis, Alexandros, Chirca, Alexandru, Arnaud, Alexis P, Narvaez-Rojas, Alexis Rafael, Kavalakat, Alfie, Spina, Alfio, Recordare, Alfonso, Annicchiarico, Alfredo, Conti, Alfredo, Mohammed, Alhassan Datti, Kocataş, Ali, Almhimid, Ali, Arnaout, Ali, Fahmy, Ali, Mangi, Ali, Modabber, Ali, Ulas, Ali Bilal, Mohamedahmed, Ali Yasen Y, Frontali, Alice, Moynihan, Alice, Yunus, Alif, Ahmad, Aline, Kent, Alistair J, Khamees, Almu'atasim, Ugwu, Aloy Okechukwu, Turan, Alparslan, Mohammed, Alsnosy Abdullah Khalefa, Navarro-Barrios, Alvaro, Yebes, Alvaro, De Sousa, Álvaro Francisco Lopes, Moreno, Amabelle, Sethi, Aman, Dawson, Amanda Caroline, Othman, Amani Alsayd Abdulsalam, Kaur, Amanjot, Wolde, Amanuel, Antonelli, Amedeo, Scifo, Amedeo, Alhamad, Ameen, Davis, Amelia, Alderazi, Amer, Harky, Amer, Mohammed-Durosinlorun, Amina, Seguya, Amina, Okhakhu, Amina, Chamakhi, Amine, Sebai, Amine, Souadka, Amine, Asla, Amir, Agrawal, Amit, Persad, Amit, Gupta, Amit, Elgazar, Amr, Kulkarni, Amruta, Coates, Amy, Bellés, Ana Ciscar, Hadzibegovic, Ana Danic, Jotic, Ana, Kowark, Ana, Martins, Ana, Pineda, Ana Mejía, Peral, Ana, Gollarte, Ana Sánchez, Senent-Boza, Ana, Camarena, Ana Isabel Avellaneda, Castaño-Leon, Ana M, Bravo, Ana Maria Minaya, Moro, Ana María Gimeno, Musina, Ana-Maria, Tapia-Herrero, Ana-María, Kothari, Anai, Gupta, Anand, Raja, Anand, Aljaiuossi, Anas, Taha, Anas, Majbar, Anass Mohammed, Prodromidou, Anastasia, Kanatas, Anastasios, Gupte, Anaya, Zakaria, Andee Dzulkarnaen, Balla, Andrea, Barberis, Andrea, Bondurri, Andrea, Bottari, Andrea, Costantino, Andrea, Figus, Andrea, Lauretta, Andrea, Mingoli, Andrea, Romanzi, Andrea, Sagnotta, Andrea, Scacchi, Andrea, Picchetto, Andrea, Valadez, Andrea Estefania Cueto, Luzzi, Andrea-Pierre, Älgå, Andreas, Fontalis, Andreas, Hecker, Andreas, Demetriades, Andreas K, Serban, Andreea-Madalina, Văcărașu, Andrei Bogdan, Cokan, Andrej, Isaza-Restrepo, Andres, Beamish, Andrew, Schache, Andrew, Stevenson, Andrew, Yiu, Andrew, Cockbain, Andrew J, Litvin, Andrey, Abad-Motos, Ane, Becerra, Angel, Ramos, Ángel Cilleruelo, Chiaradia, Angela, Dell, Angela, Romano, Angela, Pascale, Angelo, Marra, Angelo Alessandro, Dimas, Angelos, Kolias, Angelos, Cerovac, Anis, Koneru, Anish, Tidjane, Anisse, Agbeko, Anita Eseenam, Bajaj, Ankur, Gosain, Ankush, Allan, Anna, Carreras-Castañer, Anna, D'amore, Anna, Dare, Anna, Maffioli, Anna, Palepa, Anna, Paspala, Anna, Konney, Anna, Gatta, Anna Nunzia Della, Ezanno, Anne-Cecile, Yiallourou, Anneza, Kinnair, Anthony, Rayner, Anthony, Scafa, Anthony Kevin, Bowan, Antoinette Bediako, Veglia, Antonella, Russo, Antonino, Maniaci, Antonino, Castaldi, Antonio, Gil-Moreno, Antonio, Maffuz-Aziz, Antonio, Meola, Antonio, Nenna, Antonio, Ferrer, Antonio Perez, Bonilla, Antonio Ramos, Ramos-De La Medina, Antonio, Infante, Antonio Rodriguez, Santoro, Antonio, Laganà, Antonio Simone, Bateman, Antony, Michael, Antony Louis Rex, Abozid, Anwaar, Seidu, Anwar Sadat, Lowery, Aoife, Tantraworasin, Apichat, Rasheed, Aqsa, Picciariello, Arcangelo, Isik, Arda, Saif, Areeba, Anjum, Arfa, Ioannidis, Argyrios, Abeldaño, Ariel, Hussain, Arif, Nathan, Arjun, Bedzhanyan, Arkady, Perfecto, Arkaitz, De Virgilio, Armando, Galvan, Armando, Sablotzki, Armin, Böttcher, Arne, Pellacani, Arrigo, Gatti, Arthur, Ibrahimli, Arturan, Menon, Arun, Sahni, Arun, Mwenda, Aruyaru Stanley, Choudhry, Asad, Jayawardane, Asanka, Gupta, Ashish, Ramasamy, Ashok, Mitul, Ashrarur Rahman, Bawa, Ashvind, Nugur, Ashwani, Rammohan, Ashwin, Sachdeva, Ashwin, Mehraj, Asif, Yildirim, Asif, Alqaseer, Asma, Radwan, Asmaa, Sallam, Asser, Syllaios, Athanasios, Tampakis, Athanasios, Alwael, Athari, Samara, Athina, Eroglu, Atilla, Rahman, Atiqur, Ulkucu, Attila, Zaránd, Attila, Dulskas, Audrius, Tawiah, Augustine, Zani, Augusto, Vas, Aurelia, Lukosiute-Urboniene, Ausra, Adamu, Auwal, Aujayeb, Avinash, Malik, Awais Amjad, İplikçi, Ayberk, Mahmud, Ayesha, Cil, Aylin Pelin, Makanjuola, Ayomide, Akwaisah, Ayoub, Galandarova, Aysuna, Saracoglu, Ayten, Regan, Azel, Barlas, Aziz Mutlu, Alhassan, Baba Alhaji Bin, Mostafa, Badr, Hamida, Baha Ben, Torun, Bahar Canbay, Abdullah, Bahiyah, Balagobi, Balasingam, Banky, Balazs, Singh, Baljit, Alegbeleye, Bamidele, Yigit, Banu, Hajjaj, Baraa Nabil, Burgos-Blasco, Barbara, Seeliger, Barbara, Alayande, Barnabas, Alhazmi, Barrag, Enodien, Bassey, Torre, Beatrice, Pérez, Beatriz Gómez, Tamayo, Beatriz Villota, De Andrés-Asenjo, Beatriz, Quintana-Villamandos, Begoña, Girgin, Behiç, Barmayehvar, Behrad, Beisenov, Bekzat, Creavin, Ben, Dunne, Ben, Marson, Ben, Waterson, Ben, Martin, Benjamin, Zucker, Benjamin, Wong, Benjamin Ngie Xiong, Ozmen, Berk Baris, Hammond, Bernard, Mbwele, Bernard, Núñez, Bernardo, Dhondt, Bert, Gafsi, Besma, Mcleish, Bethan, Lieske, Bettina, Tailor, Bhavesh, La Pira, Biagia, Picardi, Biagio, Zampogna, Biagio, Casagranda, Biagio, Festa, Bianca Maria, Panda, Bijnya, Kirmani, Bilal, Sulaiman, Bilal, Gurung, Binay, Zacharia, Bincy, Bette, Birgit, Ayana, Birhanu, Nikolovska, Bisera, Vilaró, Blanca Capdevila, De Vega Sánchez, Blanca, Hameed, Bm Zeeshan, Diaconescu, Bogdan, Kovacevic, Bojan, Bumber, Boris, Sakakushev, Boris, Tadic, Boris, Malek, Bouhani, Alrayes, Bourhan, Thomas, Bradley, Gális, Branislav, Gallagher, Brendan, Knowles, Brett, Cunningham, Brian, Daley, Brian, Mishra, Brijesh, Ashford, Bruce, Pirozzi, Brunella Maria, Berselli, Bruno, Martinez-Leo, Bruno, Sensi, Bruno, Nardo, Bruno, Celik, Burak, Giray, Burak, Abud, Burçin, Almiqlash, Bushray, Pramesh, C S, Taskiran, Cagatay, De Campos Prado, Caio Antonio, Cipolla, Calogero, Kumar, Calvin, English, Camilla, Riccetti, Camilla, Vanni, Camilla, Brasset, Camille, Downey, Candice, Duffy, Caoimhe, Chwat, Carina, Cutmore, Carina, Sars, Carl, Ratto, Carlo, Pacilio, Carlo Alberto, De La Infiesta García, Carlos, Moreno, Carlos Guijarro, Magalhães, Carlos, Prada, Carlos, Zapata, Carlos Shiraishi, Senni, Carlotta, Flumignan, Carolina Dutra Queiroz, Martinez-Perez, Carolina, Duarte, Carolina Lugo, Garcia, Carolina Soledad Romero, Anderson, Caroline, Hing, Caroline, Cullinane, Carolyn, Cina, Caterina, Zabkiewicz, Catheriner, Sohrabi, Catrin, Guldogan, Cem Emir, Ciubotaru, Cezar, Desai, Chaitya, Raut, Chandrajit, Demetriou, Charis, Handford, Charles, Okpani, Charles, Paranjape, Charudutt, Koh, Cherry, Khatri, Chetan, Parmar, Chetan, Mok, Chi Wei, Caricato, Chiara, Marafante, Chiara, Echieh, Chidiebere Peter, Tan, Chih Ying, Ong, Chon Sum, Conso, Christel, Jardinez, Christiaan, Konrads, Christian, Warner, Christian, Makwe, Christian Chigozie, Henein, Christin, Fleming, Christina, Roland, Christina L, Maurus, Christine, Nitschke, Christine, Mittermair, Christof, Mallmann, Christoph, Andro, Christophe, Harmston, Christopher, Kuppler, Christopher, Lotz, Christopher, Nahm, Christopher, Rowe, Christopher, Ryalino, Christopher, Wallis, Christopher, Millward, Christopher Paul, Anthoulakis, Christos, Apostolou, Christos, Chouliaras, Christos, Kalfountzos, Christos, Kaselas, Christos, Vosinakis, Christos, Okereke, Chukwuma, Chean, Chung Shen, Barlow, Ciaran, Tatar, Cihad, Clancy, Cillian, Forde, Cillian, Sharpin, Claire, Mccarthy, Claire, Nestor, Claire, Warden, Claire, Ávila, Clara Castro, Massaguer, Clara, Fang, Clarissa Ern Hui, Martins, Claudia Pinto, Guerci, Claudio, Mauriello, Claudio, Holzmeister, Clemens, Miller, Clemens, Weber, Clemens, Wiesinger, Clemens Georg, Kenington, Cleo, Noel, Colin, Sue-Chue-Lam, Colin, Adumah, Collins, Neary, Colm, Sen, Comert, Fitzgerald, Conall, Ezeme, Constantine, Nastos, Constantinos, Mesina, Cristian, Bombardini, Cristina, Torregrosa, Cristina, Valdespino, Cristina Puentes, Don, Cristine Pathirannehalage, Wickramasinghe, Dakshitha, Milanesi, Damiano, Armijos, Daniel, Asiimwe, Daniel, Beswick, Daniel, Clerc, Daniel, Cox, Daniel, Doherty, Daniel, Martínez, Daniel Fernández, Lechuga, Daniel Garay, Gero, Daniel, Gil-Sala, Daniel, Lindegger, Daniel, Reim, Daniel, Shaerf, Daniel, Shmukler, Daniel, Branzan, Daniela, Filipescu, Daniela, Rega, Daniela, Bernardi, Daniele, Bissacco, Daniele, Fusario, Daniele, Morezzi, Daniele, Sabella, Danielle, Zimak, Danijela Mrazovac, Vinci, Danilo, Sale, Danjuma, Khan, Danyal Zaman, Thereska, Dariel, Andreotti, Dario, Tartaglia, Dario, Abdulai, Darling Ramatu, Mukherjee, Dattatreya, Verdi, Daunia, Idowu, 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Prashanth, Salunke, Pravin, Shah, Pritik A, Punjabi, Prof Prakash P, Christodoulou, Prokopi, Hamdan, Qusai, Tawalbeh, Ra'fat, Gadelkareem, Rabea, Awad, Rabih, Callcut, Rachael, Clegg, Rachael, Choron, Rachel, Payne, Rachel, Gefen, Rachel, Costea, Radu, Drasovean, Radu, Mirica, Radu Mihail, Ravindra, Raevin, Fajardo, Rafael Torre, Nunes, Rafael Leite, Aspide, Raffaele, Lombardi, Raffaele, Vidya, Raghavan, Elboraei, Rahma, Saaid, Rahmah, Ghodke, Rahul, Gupta, Rahul, Sharma, Rahul Deo, Lunevicius, Raimunda, Kalayarasan, Raja, Mohan, Rajashekar, Singh, Rajdeep, Sivaprakasam, Rajesh, Seenivasagam, Rajkumar Kottayasamy, Rajendram, Rajkumar, Radulescu, Raluca Bievel, Goicea, Raluca, Seshadri, Ramakrishnan Ayloor, Sarı, Ramazan, Nataraja, Ramesh, Aslam, Ramisha, Abdelemam, Rania, Shrestha, Rashmit, Bharathan, Rasiah, Pellini, Raul, Guevara, Raul, Agarwal, Ravi, Vissapragada, Ravi, Alharmi, Rawan Arahman, Sayyed, Raza, Browning, Rebecca, Critchley, Rebecca, Mallick, Rebecca, Alarabi, Rehab, Beron, Reinaldo Isaac, Függer, Reinhold, Othman, Rema, Saad, Rema, Amores, Remedios Revilla, Colombari, Renan Carlo, Radivojević, Renata Curic, Patrone, Renato, Novysedlák, René, Huatuco, René Manuel Palacio, Baertschiger, Reto, Liang, Rhea, Luckwell, Rhy, Escrevente, Ricardo, Rezende, Ricardo Fernande, Cruz, Ricardo Pedrini, Lenzi, Riccardo, Rosati, Riccardo, Donovan, Richard, Egan, Richard, Morris, Richard, Page, Richard, Seglenieks, Richard, Unsworth, Richard, Wilkin, Richard, Skipworth, Richard Je, Davies, Richard Justin, Bezirci, Rifat, Talwar, Rishi, Azami, Rizwan, Bohmer, Rob, Crichton, Robert, Fruscio, Robert, Hooker, Robert, Jach, Robert, Parker, Robert, Pillerstorff, Robert, Sinnerton, Robert, Stabler, Robert, O'connell, Robert Michael, Ragozzino, Roberta, Tutino, Roberta, Angelico, Roberta, Cammarata, Roberto, Colasanti, Roberto, Macchiavello, Roberto, Peltrini, Roberto, Pirrello, Roberto, Vaschetti, Roberto, Pires, Robinson Esteve, Papalia, Rocco, Arrangoiz, Rodrigo, Hompes, Roel, Salah, Rokeya, Pinto, Romina, Flumignan, Ronald, Callan, Rory, Cuthbert, Rory, Dennis, Rory, Scaramuzzo, Rosa, Macías, Rosa Montero, Sánchez, Rosa, Ogu, Rosemary, Ramely, Rosnelifaizur, Sgarzani, Rossella, Ramli, Roszalina, Hillier, Roxane, Thumbadoo, Ruben, Ooi, Rucira, Abdus-Salam, Rukiyat, Masri, Ruqaya, Hodgson, Russell, Mathew, Ryan, Wade, Ryckie, D'archi, Sabatino, Khan, Sabina, Ngaserin, Sabrina, Kale, Sachin, Hassan, Sadiq, Merghani, Safa, Benamar, Safia, Muhammad, Sagir, Badran, Saif, Elsahli, Saifaleslam, Heta, Saimir, Hammouche, Salah, Baeesa, Saleh, Paiella, Salvatore, Eldeen, Samaher Taj Eldeen Hassan Taj, Arkani, Samara, Mittal, Samarth, Hirji, Sameer, Tebha, Sameer, Emile, Sameh, Dbouk, Samer, Bandyopadhyay, Samik Kumar, Muhammad, Saminu, Olori, Samson, Asirifi, Samuel Amoako, Hailu, Samuel, Ling, Samuel, Newman, Samuel, Ross, Samuel, Wanjara, Samuel, Kumar, Sandip, Seneviratne, Sanjeewa, Tamburello, Sara, Suarez, Sara Busto, Ingallinella, Sara, Irshaidat, 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Pazmiño, P, Coughlin, P, Kirchweger, P, Pessaux, P, Maguire, P, Petrone, P, Cullis, P, Köglberger, P, Marriott, P, Nankivell, P, Santos-Costa, P, Martins, P, Panahi, P, Botelho, P, Teixeira, P, Escobar, P, Vázquez, P, Gribnev, P, Nolte, P, Agbonrofo, P, Bobak, P, Choong, P, Elbe, P, Hutchinson, P, Labib, P, Paal, P, Pockney, P, Reemst, P, Szatmary, P, Vaughan-Shaw, P, Alexander, P, Pucher, P, Stather, P, Foessleitner, P, Winnand, P, Zehnder, P, Kruse, P, Matos, P, Lapolla, P, Cicerchia, P, Solli, P, Di Lascio, P, Zarif, P, Champagne, P, Anoldo, P, Bertoglio, P, Fransvea, P, Familiari, P, Lombardi, P, Stogowski, P, Bruzzaniti, P, Tripathi, P, D'Sa, P, Salunke, P, Shah, P, Punjabi, P, Christodoulou, P, Hamdan, Q, Tawalbeh, R, Gadelkareem, R, Awad, R, Callcut, R, Clegg, R, Choron, R, Payne, R, Gefen, R, Costea, R, Drasovean, R, Mirica, R, Ravindra, R, Fajardo, R, Nunes, R, Aspide, R, Lombardi, R, Vidya, R, Elboraei, R, Saaid, R, Ghodke, R, Gupta, R, Sharma, R, Lunevicius, R, Kalayarasan, R, Mohan, R, Singh, R, Sivaprakasam, R, Seenivasagam, R, Rajendram, R, Radulescu, R, Goicea, R, Seshadri, R, Sarı, R, Nataraja, R, Aslam, R, Abdelemam, R, Shrestha, R, Bharathan, R, Pellini, R, Guevara, R, Agarwal, R, Vissapragada, R, Alharmi, R, Sayyed, R, Browning, R, Critchley, R, Mallick, R, Alarabi, R, Beron, R, Függer, R, Othman, R, Saad, R, Amores, R, Colombari, R, Radivojević, R, Patrone, R, Novysedlák, R, Huatuco, R, Baertschiger, R, Liang, R, Luckwell, R, Escrevente, R, Rezende, R, Cruz, R, Lenzi, R, Rosati, R, Donovan, R, Egan, R, Morris, R, Page, R, Seglenieks, R, Unsworth, R, Wilkin, R, Skipworth, R, Davies, R, Bezirci, R, Talwar, R, Azami, R, Bohmer, R, Crichton, R, Fruscio, R, Hooker, R, Jach, R, Parker, R, Pillerstorff, R, Sinnerton, R, Stabler, R, O'Connell, R, Ragozzino, R, Tutino, R, Angelico, R, Cammarata, R, Colasanti, R, Macchiavello, R, Peltrini, R, Pirrello, R, Vaschetti, R, Pires, R, Papalia, R, Arrangoiz, R, Hompes, R, Salah, R, Pinto, R, Flumignan, R, Callan, R, Cuthbert, R, Dennis, R, Scaramuzzo, R, Macías, R, Sánchez, R, Ogu, R, Ramely, R, Sgarzani, R, Ramli, R, Hillier, R, Thumbadoo, R, Ooi, R, Abdus-Salam, R, Masri, R, Hodgson, R, Mathew, R, Wade, R, D'Archi, S, Khan, S, Ngaserin, S, Kale, S, Hassan, S, Merghani, S, Benamar, S, Muhammad, S, Badran, S, Elsahli, S, Heta, S, Hammouche, S, Baeesa, S, Paiella, S, Eldeen, S, Arkani, S, Mittal, S, Hirji, S, Tebha, S, Emile, S, Dbouk, S, Bandyopadhyay, S, Olori, S, Asirifi, S, Hailu, S, Ling, S, Newman, S, Ross, S, Wanjara, S, Kumar, S, Seneviratne, S, Tamburello, S, Suarez, S, Ingallinella, S, Irshaidat, S, Konswa, S, Mambrilla, S, Nasser, S, Parini, S, Pitoni, S, Ornaghi, S, Rodrigues, S, Abdelmohsen, S, Aitken, S, Tian, S, Badiani, S, Ahmad, S, Swed, S, Muthu, S, Lakpriya, S, Alzahrani, S, Mikalauskas, S, Lasrado, S, Satoskar, S, Bawa, S, Altiner, S, Garcia, S, Stevens, S, Demir, S, Ken-Amoah, S, Tranca, S, Ziemann, S, Awad, S, Atici, S, Subramaniam, S, Erel, S, Jiang, S, Efetov, S, Efremov, S, Katorkin, S, Valladares, S, Contreras, S, Meriç, S, Zenger, S, Safi, S, Leventoğlu, S, Elsalhawy, S, Shaikh, S, Sheik, S, Islam, S, Shamim, S, Waqar, S, Farid, S, Seraj, S, Sundarraju, S, Karandikar, S, Sambhwani, S, Chopra, S, Chowdhury, S, Laura, S, Ahmed, S, Wason, S, Tan, S, Fraser, S, Williams, S, Ghozy, S, Abdelmawgoud, S, Shehata, S, Sharma, S, Al-Touny, S, Ramzanali, S, Nah, S, Jansen, S, Rajan, S, Dindyal, S, Amin, S, Shoukrie, S, Karar, S, Patkar, S, Abdulsalam, S, Lin, S, Hegde, S, Fiorelli, S, Quaresima, S, Redondo, S, Palmisano, S, Ruggiero, S, Balogun, S, Cais, S, Cole, S, Federer, S, Le Roux, S, Ippoliti, S, Meneghini, S, Viola, S, Manfredelli, S, Novello, S, Gananadha, S, Mesli, S, Tani, S, Malik, S, Anastasiadou, S, Boligo, S, Esposito, S, Valanci, S, Xenaki, S, Pejkova, S, Trungu, S, Basu, S, Alkhatib, S, Pérez-Bertólez, S, Flores, S, Donoghue, S, Lunca, S, Orsoo, S, Potamianos, S, Devarakonda, S, Suresh, S, Croghan, S, Turi, S, Capella, S, Lucchini, S, Magnone, S, Salizzoni, S, Scabini, S, Scaringi, S, Cioffi, S, Seyfried, S, Degener, S, Potten, S, Taha-Mehlitz, S, Ali, S, Angamuthu, S, Mcaleer, S, Knight, S, White, S, Mantziari, S, Kykalos, S, Goh, S, Ibrahim, S, Elzwai, S, Bansal, S, Tripathy, S, Amrayev, S, Anwar, S, Banerjee, S, Thakar, S, Saeed, S, Venkatappa, S, Das, S, Techapongsatorn, S, Dube, S, Lee, S, González-Suárez, S, Henriques, S, Konjevoda, S, Gisbertz, S, Bravo, S, Mannan, S, Bukhari, S, Zafar, S, Batista, S, Chin, S, Arif, T, Lawal, T, Aktokmakyan, T, Osborn, T, Szakmany, T, Sztipits, T, Triantafyllou, T, Valadez, T, Singh, T, Khaliq, T, Patel, T, Fadalla, T, Jichi, T, Sammour, T, Al-Shaiji, T, Naggs, T, Barišić, T, Nikolouzakis, T, Bisgin, T, Perra, T, Uprak, T, Dagklis, T, Liakakos, T, Sidiropoulos, T, Adjeso, T, Dölker, T, Oung, T, Aherne, T, Diehl, T, Pinkney, T, Raymond, T, Rhomberg, T, Schmitz-Rixen, T, Madhuri, T, Lohmann, T, Yeoh, T, Zaimis, T, Bright, T, Vilz, T, Glowka, T, Board, T, Hardcastle, T, Cohnert, T, Mahečić, T, William, T, Klatte, T, Abbott, T, Watcyn-Jones, T, Mendes, T, Kulis, T, Sečan, T, Campagnaro, T, Frisoni, T, Simoncini, T, Violante, T, Safranovs, T, Risteski, T, Pang, T, Akinyemi, T, Yotsov, T, Laeke, T, Kochiyama, T, Sholadoye, T, Alekberli, T, Ezomike, U, Giustizieri, U, Grossi, U, Köksoy, Ü, Bork, U, Kisser, U, Ronellenfitsch, U, Saeed, U, Bracale, U, Jayarajah, U, Rauf, U, Bumbasirevic, U, Ferrer, U, Ahmed, U, Bello, U, Jogiat, U, Sadia, U, Galandarov, V, Narayanan, V, Calu, V, Bianchi, V, Ciniero, V, Tonini, V, Silvestri, V, Vijay, V, Dewan, V, Lohsiriwat, V, Thuduvage, V, Mousafeiris, V, Dragisic, V, Sasireka, V, Santric, V, Kusuma, V, Kolli, V, Alonso, V, De Simone, V, Picotti, V, Martínez, V, Panduro-Correa, V, Kakotkin, V, Angulo, V, Turrado-Rodriguez, V, Krishnamoorthy, V, Ban, V, Shah, V, Maiola, V, Giordano, V, La Vaccara, V, Lizzi, V, Papagni, V, Schiavone, V, Satchithanantham, V, Garcia-Virto, V, Jimenez, V, Kumar, V, Shelat, V, Bhat, V, Sodhai, V, Graziadei, V, Kutuzov, V, Stoyanov, V, Oktseloglou, V, Flis, V, Elhassan, W, Yang, W, Soon, W, Tashkandi, W, Al-Khyatt, W, Mabood, W, Bijou, W, Wijenayake, W, D, W, Krawczyk, W, Atkins, W, Bolton, W, White, W, Ceelen, W, Vagena, X, Gozal, Y, Baba, Y, Subramani, Y, Jansen, Y, Mittal, Y, Kara, Y, Zwain, Y, Noureldin, Y, Alawneh, Y, Aydin, Y, Lam, Y, Tang, Y, Lim, Y, Dean, Y, Tanas, Y, Su, Y, Fujimoto, Y, Altinel, Y, Frolova, Y, Oshodi, Y, Fadel, Z, Zahid, Z, Elahi, Z, Djama, Z, Zaheen, Z, Jawad, Z, Demetrashvili, Z, Gebremeskel, Z, Gudisa, Z, Alyami, Z, Garoufalia, Z, Li, Z, Zimak, Z, Radin, Z, and Balogh, Z
Subjects: general surgery, acute care surgery, Settore MED/18 - CHIRURGIA GENERALE, climate change, trauma, Settore MED/40 - Ginecologia E Ostetricia, environmental impact, surgery, Settore MED/31 - Otorinolaringoiatria, None, Medicine and Health Sciences, Surgery, operating theatre, environment
Abstract: Background: Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods: This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low-middle-income countries. Results: In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of 'single-use' consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low-middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion: This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high- and low-middle-income countries.
Published: 2023

41. Explaining Mercosur's Survival: Strategic Sources of Argentine-Brazilian Convergence

Author: Mera, Laura Gomez
Published: 2005

42. New Observations of NO2 in the Upper Troposphere from TROPOMI

Author: Eloise A Marais, John F Roberts, Robert G Ryan, Henk Eskes, K Folkert Boersma, Sungyeon Choi, Joanna Joiner, Nader Abuhassan, Alberto Redondas, Michel Grutter, Alexander Cede, Laura Gomez, and Monica Navarro-Comas
Subjects: Geosciences (General)
Published: 2021
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43. Altimetry for the Future: Building on 25 Years of Progress

Author: Saleh Abdalla, Abdolnabi Abdeh Kolahchi, Susheel Adusumilli, Suchandra Aich Bhowmick, Eva Alou-Font, Laiba Amarouche, Ole Baltazar Andersen, Helena Antich, Lotfi Aouf, Brian Arbic, Thomas Armitage, Sabine Arnault, Camila Artana, Giuseppe Aulicino, Nadia Ayoub, Sergei Badulin, Steven Baker, Chris Banks, Lifeng Bao, Silvia Barbetta, Barbara Barcelo-Llull, Francois Barlier, Sujit Basu, Peter Bauer-Gottwein, Matthias Becker, Brian Beckley, Nicole Bellefond, Tatyana Belonenko, Mounir Benkiran, Touati Benkouider, Ralf Bennartz, Jerome Benveniste, Nicolas Bercher, Muriel Berge-Nguyen, Joao Bettencourt, Fabien Blarel, Alejandro Blazquez, Denis Blumstein, Pascal Bonnefond, Franck Borde, Jerome Bouffard, Francois Boy, Jean-Paul Boy, Cedric Brachet, Pierre Brasseur, Alexander Braun, Luca Brocca, David Brockley, Laurent Brodeau, Shannon Brown, Sean Bruinsma, Anna Bulczak, Sammie Buzzard, Madeleine Cahill, Stephane Calmant, Michel Calzas, Stefania Camici, Mathilde Cancet, Hugues Capdeville, Claudia Cristina Carabajal, Loren Carrere, Anny Cazenave, Eric P. Chassignet, Prakash Chauhan, Selma Cherchali, Teresa Chereskin, Cecile Cheymol, Daniele Ciani, Paolo Cipollini, Francesca Cirillo, Emmanuel Cosme, Steve Coss, Yuri Cotroneo, David Cotton, Alexandre Couhert, Sophie Coutin-Faye, Jean-Francois Cretaux, Frederic Cyr, Francesco d’Ovidio, Jose Darrozes, Cedric David, Nadim Dayoub, Danielle De Staerke, Xiaoli Deng, Shailen Desai, Jean-Damien Desjonqueres, Denise Dettmering, Alessandro Di Bella, Lara Dıaz-Barroso, Gerald Dibarboure, Habib Boubacar Dieng, Salvatore Dinardo, Henryk Dobslaw, Guillaume Dodet, Andrea Doglioli, Alessio Domeneghetti, David Donahue, Shenfu Dong, Craig Donlon, Joel Dorandeu, Christine Drezen, Mark Drinkwater, Yves Du Penhoat, Brian Dushaw, Alejandro Egido, Svetlana Erofeeva, Philippe Escudier, Saskia Esselborn, Pierre Exertier, Ronan Fablet, Cedric Falco, Sinead Louise Farrell, Yannice Faugere, Pierre Femenias, Luciana Fenoglio, Joana Fernandes, Juan Gabriel Fernandez, Pascale Ferrage, Ramiro Ferrari, Lionel Fichen, Paolo Filippucci, Stylianos Flampouris, Sara Fleury, Marco Fornari, Rene Forsberg, Frederic Frappart, Marie-laure Frery, Pablo Garcia, Albert Garcia-Mondejar, Julia Gaudelli, Augusto Getirana, Lucile Gaultier, Ferran Gibert, Artur Gil, Lin Gilbert, Sarah Gille, Luisella Giulicchi, Jesus Gomez-Enri, Laura Gomez-Navarro, Christine Gommenginger, Lionel Gourdeau, David Griffin, Andreas Groh, Alexandre Guerin, Raul Guerrero, Thierry Guinle, Praveen Gupta, Benjamin D. Gutknecht, Mathieu Hamon, Guoqi Han, Daniele Hauser, Veit Helm, Stefan Hendricks, Fabrice Hernandez, Anna Hogg, Martin Horwath, Martina Idzanovic, Peter Janssen, Eric Jeansou, Yongjun Jia, Yuanyuan Jia, Liguang Jiang, Johnny A. Johannessen, Masafumi Kamachi, Svetlana Karimova, Kathryn Kelly, Sung Yong Kim, Robert King, Cecile M.M. Kittel, Patrice Klein, Anna Klos, Per Knudsen, Rolf Koenig, Andrey Kostianoy, Alexei Kouraev, Raj Kumar, Sylvie Labroue, Loreley Selene Lago, Juliette Lambin, Lea Lasson, Olivier Laurain, Remi Laxenaire, Clara Lazaro, Sophie Le Gac, Julien Le Sommer, Pierre-Yves Le Traon, Sergey Lebedev, Fabien Leger, Benoit Legresy, Frank Lemoine, Luc Lenain, Eric Leuliette, Marina Levy, John Lillibridge, Jianqiang Liu, William Llovel, Florent Lyard, Claire Macintosh, Eduard Makhoul Varona, Cécile Manfredi, Frédéric Marin, Evan Mason, Christian Massari, Constantin Mavrocordatos, Nikolai Maximenko, Malcolm McMillan, Thierry Medina, Angelique Melet, Marco Meloni, Stelios Mertikas, Sammy Metref, Benoit Meyssignac, Jean-François Minster, Thomas Moreau, Daniel Moreira, Yves Morel, Rosemary Morrow, John Moyard, Sandrine Mulet, Marc Naeije, Robert Steven Nerem, Hans Ngodock, Karina Nielsen, Jan Even Øie Nilsen, Fernando Niño, Carolina Nogueira Loddo, Camille Noûs, Estelle Obligis, Inès Otosaka, Michiel Otten, Berguzar Oztunali Ozbahceci, Roshin P. Raj, Rodrigo Paiva, Guillermina Paniagua, Fernando Paolo, Adrien Paris, Ananda Pascual, Marcello Passaro, Stephan Paul, Tamlin Pavelsky, Christopher Pearson, Thierry Penduff, Fukai Peng, Felix Perosanz, Nicolas Picot, Fanny Piras, Valerio Poggiali, Étienne Poirier, Sonia Ponce de León, Sergey Prants, Catherine Prigent, Christine Provost, M-Isabelle Pujol, Bo Qiu, Yves Quilfen, Ali Rami, R. Keith Raney, Matthias Raynal, Elisabeth Remy, Frédérique Rémy, Marco Restano, Annie Richardson, Donald Richardson, Robert Ricker, Martina Ricko, Eero Rinne, Stine Kildegaard Rose, Vinca Rosmorduc, Sergei Rudenko, Simón Ruiz, Barbara J. Ryan, Corinne Salaün, Antonio Sanchez-Roman, Louise Sandberg Sørensen, David Sandwell, Martin Saraceno, Michele Scagliola, Philippe Schaeffer, Martin G. Scharffenberg, Remko Scharroo, Andreas Schiller, Raphael Schneider, Christian Schwatke, Andrea Scozzari, Enrico Ser-giacomi, Frederique Seyler, Rashmi Shah, Rashmi Sharma, Andrew Shaw, Andrew Shepherd, Jay Shriver, C.K. Shum, Wim Simons, Sebatian B. Simonsen, Thomas Slater, Walter Smith, Saulo Soares, Mikhail Sokolovskiy, Laurent Soudarin, Ciprian Spatar, Sabrina Speich, Margaret Srinivasan, Meric Srokosz, Emil Stanev, Joanna Staneva, Nathalie Steunou, Julienne Stroeve, Bob Su, Yohanes Budi Sulistioadi, Debadatta Swain, Annick Sylvestre-baron, Nicolas Taburet, Rémi Tailleux, Katsumi Takayama, Byron Tapley, Angelica Tarpanelli, Gilles Tavernier, Laurent Testut, Praveen K. Thakur, Pierre Thibaut, LuAnne Thompson, Joaquín Tintoré, Céline Tison, Cédric Tourain, Jean Tournadre, Bill Townsend, Ngan Tran, Sébastien Trilles, Michel Tsamados, Kuo-Hsin Tseng, Clément Ubelmann, Bernd Uebbing, Oscar Vergara, Jacques Verron, Telmo Vieira, Stefano Vignudelli, Nadya Vinogradova Shiffer, Pieter Visser, Frederic Vivier, Denis Volkov, Karina von Schuckmann, Valerii Vuglinskii, Pierrik Vuilleumier, Blake Walter, Jida Wang, Chao Wang, Christopher Watson, John Wilkin, Josh Willis, Hilary Wilson, Philip Woodworth, Kehan Yang, Fangfang Yao, Raymond Zaharia, Elena Zakharova, Edward D. Zaron, Yongsheng Zhang, Zhongxiang Zhao, Vadim Zinchenko, and Victor Zlotnicki
Subjects: Space Sciences (General), Geosciences (General)
Abstract: In 2018 we celebrated 25 years of development of radar altimetry, and the progress achieved by this methodology in the fields of global and coastal oceanography, hydrology, geodesy and cryospheric sciences. Many symbolic major events have celebrated these developments, e.g., in Venice, Italy, the 15th (2006) and 20th (2012) years of progress and more recently, in 2018, in Ponta Delgada, Portugal, 25 Years of Progress in Radar Altimetry. On this latter occasion it was decided to collect contributions of scientists, engineers and managers involved in the worldwide altimetry community to depict the state of altimetry and propose recommendations for the altimetry of the future. This paper summarizes contributions and recommendations that were collected and provides guidance for future mission design, research activities, and sustainable operational radar altimetry data exploitation. Recommendations provided are fundamental for optimizing further scientific and operational advances of oceanographic observations by altimetry, including requirements for spatial and temporal resolution of altimetric measurements, their accuracy and continuity. There are also new challenges and new openings mentioned in the paper that are particularly crucial for observations at higher latitudes, for coastal oceanography, for cryospheric studies and for hydrology. The paper starts with a general introduction followed by a section on Earth System Science including Ocean Dynamics, Sea Level, the Coastal Ocean, Hydrology, the Cryosphere and Polar Oceans and the ‘‘Green” Ocean, extending the frontier from biogeochemistry to marine ecology. Applications are described in a subsequent section, which covers Operational Oceanography, Weather, Hurricane Wave and Wind Forecasting, Climate projection. Instruments’ development and satellite missions’ evolutions are described in a fourth section. A fifth section covers the key observations that altimeters provide and their potential complements, from other Earth observation measurements to in situ data. Section 6 identifies the data and methods and provides some accuracy and resolution requirements for the wet tropospheric correction, the orbit and other geodetic requirements, the Mean Sea Surface, Geoid and Mean Dynamic Topography, Calibration and Validation, data accuracy, data access and handling (including the DUACS system). Section 7 brings a transversal view on scales, integration, artificial intelligence, and capacity building (education and training). Section 8 reviews the programmatic issues followed by a conclusion.
Published: 2021
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44. Tracing the Iceland plume and North East Atlantic breakup in the lithosphere

Author: Dacal, Maria Laura Gomez, primary, Scheck-Wenderoth, Magdalena, additional, Faleide, Jan Inge, additional, Abdelmalak, Mohamed Mansour, additional, Bott, Judith, additional, and Anikiev, Denis, additional
Published: 2023
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45. Mohorovicic Discontinuity Depth Analysis Beneath North Patagonian Massif

Author: Dacal, Marı́a Laura Gómez, Tocho, Claudia, Aragón, Eugenio, Rizos, Chris, Series editor, and Willis, Pascal, editor
Published: 2016
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46. Experimental results and strength model identification of pure iridium

Author: Scapin, Martina, Peroni, Lorenzo, Torregrosa, Claudio, Perillo-Marcone, Antonio, Calviani, Marco, Pereira, Laura Gomez, Léaux, Floriane, and Meyer, Mickaël
Published: 2017
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47. In vitro assessment of skin irritation potential of graphene based materials using reconstructed human epidermis (RhE)

Author: NATALIA FERNANDEZ PAMPIN, JUAN ANTONIO TAMAYO RAMOS, NANDITA DASGUPTA, DALIA DE LA FUENTE VIVAS, ROCIO BARROS GARCIA, SONIA MARTEL MARTIN, LAURA GOMEZ CUADRADO, and CARLOS RUMBO LORENZO
Abstract: Graphene-based materials (GBMs) have attracted a lot of attention during the last years due to their extraordinary physicochemical properties. These materials are employed in a wide range of fields, including electronic and biomedical applications1,2,3. From a safety perspective, the major risk for human health associated to these materials is currently related to occupational exposure4, being the inhalation and dermal contact the most relevant routes of exposure to GBMs5. In fact, around 90 % of skin diseases associated with occupational settings are represented by irritant and allergic contact dermatitis6. However, the existing information about cutaneous toxicity of GBMs is scarce. Considering the possible risks in the work environment due to the skin irritation potential of these materials, the present study investigated the cutaneous toxicity of a group of GBMs, including small flakes graphene (SFG), large flakes graphene (LFG) and graphene nanoplatelets (GNplatelets). The inclusion of New Approach Methods (NAMs) for skin sensitization into Organization for Economic Co-operation and Development (OECD) has proved to be a good replacement of animal models. This methodology simulates the human exposure by direct epidermal contact to chemicals. Therefore, to evaluate the skin toxicity, the in vitro EpiDerm Skin Irritation Test (EPI-200-SIT) was employed. Following the OECD Test Nº 439 to determine in vitro skin irritation on reconstructed human epidermis (RhE), it was observed that none of the GBMs caused damage to the tissues. According to EU and Globally Harmonized System of Classification and Labelling Chemicals, GHS, (R38 / Category 2 or no label), an irritant is predicted if the viability of the tissues exposed to the test substance is reduced below 50 % of the viability of the controls. In the case of these GBMs, these materials did not reduce the tissues viability, so they can be considered as non-irritant in the tested conditions. These results provide new insights about the skin irritation potential of GBMs with different properties, demonstrating that the hazard assessment using human in vitro models is a critical aspect to increase the knowledge on their potential impact upon human health. This study is part of the project DIAGONAL (H2020, NMBP-16-2020, Grant Agreement no 953152), which aims to address existing gaps at risk assessment, risk management and risk governance levels providing new knowledge on multicomponent nanomaterials and high aspect ratio nanomaterials.
Published: 2023
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48. Comparison Of Metal Toxicities Commonly Used For Photocatalysis: Review And Recommendations

Author: DASGUPTA, NANDITA, NATALIA FERNANDEZ PAMPIN, VIVAS, DALIA DE LA FUENTE, CUADRADO, LAURA GOMEZ, GARCIA, ROCIO BARROS, MARTIN, SONIA MARTEL, and LORENZO, CARLOS RUMBO
Abstract: Metal components and nanoparticles are used to develop new heterogeneous photocatalysts with desired properties both in laboratory and industrial scale. In addition to the appropriate mechanical and physical properties that newly developed materials should present to allow their use in the areas of interest, the potential impact that they represent for the human health and the environment is another critical factor that should be considered before their implementation. We assessed the toxicity of 14 different metals and nanomaterials. Based upon the literature survey, the inert or least toxic metals to human health and environment from the selected materials include Tin, Nickel, Aluminium and Titanium dioxide when used in pure composition. Metals such as Zinc, Iron and Copper becomes toxic after a certain concentration. The only toxic metal from the selected components was Antimony, which exerts toxic effect even at low concentration. It should also be noted that toxicity of metals depends upon duration, dosage of exposure, the chemical combination or susceptibility. The choice of nanoparticles for photocatalyst with less toxicity include gold and iron carbide while toxicity towards human health was observed for ruthenium oxide, titanium dioxide and manganese nanoparticle. It should also be noted that toxicity of nanoparticles has conflicting data since size, shape and functionalization are the main factor in determining the toxicity of nanoparticles rather than the chemical composition. The present review and recommendations will help to design safer photocatalysts
Published: 2023
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49. Development of an approach to characterize nanoparticles toxicity in the environment throug toxicokinetics and toxicodynamics analysis in biofilms pseudomonas putida

Author: VIVAS, DALIA DE LA FUENTE, FERNANDEZ, SARA COLLADO, NATALIA FERNANDEZ PAMPIN, DASGUPTA, NANDITA, CUADRADO, LAURA GOMEZ, MARTA BACCARO, Van Den Brink, Nico W., GARCIA, ROCIO BARROS, MARTIN, SONIA MARTEL, JUAN ANTONIO TAMAYO RAMOS, and LORENZO, CARLOS RUMBO
Abstract: Due to their exceptional characteristics, nanomaterials are applied in multiple fields, including automotive, textiles or biomedical sectors, being Nanotechnology conceived as a Key Enabling Technology (KET). For this reason, the risks to health and environment posed by the special particularities of nanomaterial enabled products are critical to identify and control their associated hazards. Environmental research has focussed on elucidating and modelling of toxicokinetics and toxicodynamics of different types of nanomaterials in soil and aquatic organisms. In this regard, biofilms are considered as good bioindicators of contamination due to their ability to accumulate and react quickly to xenobiotics. Despite this, currently there is not any OECD validated protocol to study toxicokinetics and toxicodynamics of xenobiotics, and there is only one available study in the current literature where both parameters are analysed in these structures (Chaumet et al., 2019) The aim of this work was to set up the appropriate conditions to develop a protocol to study Multi-Component NanoMaterials (MCNMs) and High Aspect Ratio Nanoparticles (HARNs) tokicokinetics and toxicodynamics in biofilms. Pseudomonas putida, a Gram-negative bacterium that can be found in soils being involved in several relevant functions, was selected as model organism. Different conditions of temperature, surface material, incubation time etc. were tested in order to obtain significant biofilm biomass to perform toxicokinetic studies. Results showed that the incubation of bacterial cultures during 96 hours at 37°C, in polystyrene well plates coated with a polyelectrolyte lead to the highest amount of biofilm. For toxicodynamics studies, ROS production was selected as a parameter to be analysed using the CM-H2DCFDA dye. The appropriate experimental conditions were first set up with planktonic bacteria exposed to H2O2, and then applied in biofilms. This study has received funding from the European Union’s Horizon 2020 program (DIAGONAL, Grant Agreement no 953152). The DIAGONAL project aims to address existing gaps at risk assessment, risk management and risk governance levels providing new knowledge on multicomponent nanomaterials and high aspect ratio nanomaterials.
Published: 2023
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50. Tracing the Iceland plume and North East Atlantic breakup in the lithosphere

Author: Maria Laura Gomez Dacal, Magdalena Scheck-Wenderoth, Jan Inge Faleide, Mohamed Mansour Abdelmalak, Judith Bott, and Denis Anikiev
Abstract: Plumes are domains where hotter material rises through Earth´s mantle, heating also the moving lithospheric plates and causing thinning or even continental breakup. In particular, the Iceland plume in the NE Atlantic (NEA) could have been instrumental in facilitating the breakup between Europe and Laurentia in the earliest Eocene, 55 Ma. This hypothesis relies on different observations that have not yet been integrated into a quantitative description of the present-day geophysical configuration. Here we show an open access three-dimensional model of the entire NEA crust and upper mantle including the conjugate continental margins of Greenland and Norway, as well as the sheared margins of the northernmost NEA. The model is consistent with available seismic, seismological and gravity data. We propose that high-density/high-velocity anomalies in the crust represent the preserved modifications of the lithosphere in consequence of the plate’s journey over the hot mantle plume. Besides, low-density/low-velocity anomalies in the uppermost mantle would represent the present-day effect of the mantle plume and its interaction with the mid-ocean ridges. Overall, the model indicates that the presence of the plume together with the pre-existing crustal configuration controlled the timing, mechanisms and localization of the NEA breakup.
Published: 2023

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