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145 results on '"Laumen, Jolein"'

5. Antimicrobial Susceptibility of Commensal Neisseria spp. in Parents and Their Children in Belgium: A Cross-Sectional Survey

Author

Abdellati, Said, primary, Gestels, Zina, additional, Laumen, Jolein, additional, Van Dijck, Christophe, additional, De Baetselier, Irith, additional, de Block, TEssa, additional, Van den Bossche, Dorien, additional, Manoharan-Basil, Sheeba Santhini, additional, Kanesaka, Izumo, additional, Vanbaelen, Thibaut, additional, and Kenyon, Chris, additional

Published
2024
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6. Antibacterial mouthwash to prevent sexually transmitted infections in men who have sex with men taking HIV pre-exposure prophylaxis (PReGo): a randomised, placebo-controlled, crossover trial

Author

Van Dijck, Christophe, Tsoumanis, Achilleas, Rotsaert, Anke, Vuylsteke, Bea, Van den Bossche, Dorien, Paeleman, Elke, De Baetselier, Irith, Brosius, Isabel, Laumen, Jolein, Buyze, Jozefien, Wouters, Kristien, Lynen, Lutgarde, Van Esbroeck, Marjan, Herssens, Natacha, Abdellati, Said, Declercq, Steven, Reyniers, Thijs, Van Herrewege, Yven, Florence, Eric, and Kenyon, Chris

Published
2021
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9. Could traces of fluoroquinolones in food induce ciprofloxacin resistance in Escherichia coli and Klebsiella pneumoniae ? An in vivo study in Galleria mellonella with important implications for maximum residue limits in food

Author

Gestels, Zina, primary, Baranchyk, Yuliia, additional, Van den Bossche, Dorien, additional, Laumen, Jolein, additional, Abdellati, Said, additional, Britto Xavier, Basil, additional, Manoharan-Basil, Sheeba Santhini, additional, and Kenyon, Chris, additional

Published
2024
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13. Effect on the Resistome of Dual vs Monotherapy for the Treatment of Neisseria gonorrhoeae: Results From a Randomized Controlled Trial (ResistAZM Trial)

Author

Thibaut, Vanbaelen, primary, Eric, Florence, additional, Christophe, Van Dijck, additional, Achilleas, Tsoumanis, additional, Laumen, Jolein Gyonne Elise, additional, Sheeba, Manoharan-Basil Santhini, additional, Saïd, Abdellati, additional, De Block, Tessa, additional, Irith, De Baetselier, additional, Dorien, Van den Bossche, additional, Yven, Van Herrewege, additional, Anke, Rotsaert, additional, and Chris, Kenyon, additional

Published
2023
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17. Antimicrobial susceptibility of commensal Neisseria spp. in parents and their children in Belgium: a cross-sectional survey.

Author

Abdellati, Saïd, Gestels, Zina, Laumen, Jolein Gyonne Elise, Van Dijck, Christophe, De Baetselier, Irith, de Block, Tessa, Van den Bossche, Dorien, Vanbaelen, Thibaut, Kanesaka, Izumo, Manoharan-Basil, Sheeba Santhini, and Kenyon, Chris

Subjects
HORIZONTAL gene transfer, PATHOGENIC bacteria, DENITRIFICATION, NEISSERIA, DRUG resistance in microorganisms
Abstract

Background: commensal Neisseria species are part of the oropharyngeal microbiome and play an important role in nitrate reduction and protecting against colonization by pathogenic bacteria. They do, however, also serve as a reservoir of antimicrobial resistance. Little is known about the prevalence of these species in the general population, how this varies by age and how antimicrobial susceptibility varies between species. Methods: we assessed the prevalence and antimicrobial susceptibility of commensal Neisseria species in the parents (n  = 38) and children (n  = 50) of 35 families in Belgium. Results: various commensal Neisseria (n  = 5) could be isolated from the participants. Most abundant were N. subflava and N. mucosa. Neisseria subflava was detected in 77 of 88 (87.5%) individuals and N. mucosa in 64 of 88 (72.7%). Neisseria mucosa was more prevalent in children [41/50 (82%)] than parents [23/38 (60.5%); P  < .05], while N. bacilliformis was more prevalent in parents [7/36 (19.4%)] than children [2/50 (4%); P  < .05]. Neisseria bacilliformis had high ceftriaxone minimum inhibitory concentrations (MICs; median MIC 0.5 mg/l; IQR 0.38–0.75). The ceftriaxone MICs of all Neisseria isolates were higher in the parents than in the children. This could be explained by a higher prevalence of N. bacilliformis in the parents. Interpretation: the N. bacilliformis isolates had uniformly high ceftriaxone MICs which warrant further investigation. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Preventing and understanding the emergence of antimicrobial resistance in **Neisseria gonorrhoeae**

Author

Laumen, Jolein, Kenyon, Chris, and Malhotra, Surbhi

Subjects
Pharmacology. Therapy
Abstract

Gonorrhoea is the second most prevalent bacterial sexually transmittable infection (STI) worldwide. The bacterium Neisseria gonorrhoeae has developed resistance to all currently and previously recommended antibiotics used to treat it. In the first section of this thesis, we investigate the factors underpinning resistance in STI core-groups. We characterized the molecular pathways via which azithromycin resistance emerges in N. gonorrhoeae. In addition to the known macrolide resistance conferring mutations at the target binding site and the efflux pump, we discovered novel ribosomal protein mutations. We show that a population exposed to high levels of antibiotics due to frequent STI screening, has more resistant commensal Neisseria species in their throat compared to the general population. As commensal Neisseria species play an important role in the evolution of antimicrobial resistance in the pathogenic N. gonorrhoeae, including them in monitoring activities could serve as an early warning system. In the second section of this thesis, we evaluate new antibiotic sparing treatment options for gonorrhoea. Although we were unable to isolate bacteriophages effective against currently circulating N. gonorrhoeae strains, throat samples tested did exhibit antigonococcal activity. Bacteriocins, which could be promising alternatives to antibiotics and offer a novel strategy to prevent and treat gonorrhoeae infection, may be responsible for the observed lysis. Next, we assessed the consequences of using mouthwashes as alternative treatment. We report that chlorhexidine sensitivity might diminish after prolonged exposure, and even more concerning, it may cause cross-resistance to antibiotics currently used to treat gonorrhoea. Resistance to Listerine could not be induced, but daily Listerine use did influence the oropharyngeal microbiome. These findings imply that mouthwash applications may have unintended consequences and should be carefully considered.

Published
2023

20. The Discovery of Oropharyngeal Microbiota with Inhibitory Activity against Pathogenic Neisseria gonorrhoeae and Neisseria meningitidis: An In Vitro Study of Clinical Isolates

Author

Akomoneh, Elvis Achondou, primary, Laumen, Jolein Gyonne Elise, additional, Abdellati, Saïd, additional, Van Dijck, Christophe, additional, Vanbaelen, Thibau, additional, Britto, Xavier Basil, additional, Manoharan-Basil, Sheeba S., additional, and Kenyon, Chris, additional

Published
2022
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24. A Novel Method to Assess Antimicrobial Susceptibility in Commensal Oropharyngeal Neisseria—A Pilot Study

Author

Laumen, Jolein J.G.E., Abdellati, Said, Van Dijck, Christophe, Martiny, Delphine, De Baetselier, Irith, Manoharan-Basil, Sheeba Santhini, van den Bossche, Dorien, Kenyon, Christopher, Laumen, Jolein J.G.E., Abdellati, Said, Van Dijck, Christophe, Martiny, Delphine, De Baetselier, Irith, Manoharan-Basil, Sheeba Santhini, van den Bossche, Dorien, and Kenyon, Christopher

Abstract

Commensal Neisseria provide a reservoir of resistance genes that can be transferred to the pathogens Neisseria gonorrhoeae and N. meningitidis in the human oropharynx. Surveillance pro-grams are thus needed to monitor resistance in oropharyngeal commensal Neisseria, but currently the isolation and antimicrobial susceptibility testing of these commensals is laborious, complex and expensive. In addition, the posterior oropharyngeal/tonsillar swab, which is commonly used to sample oropharyngeal Neisseria, is poorly tolerated by many individuals. We evaluated an alter-native non-invasive method to isolate oropharyngeal commensal Neisseria and to detect decreased susceptibility to azithromycin using selective media (LBVT.SNR) with and without azithromycin (2 µg/mL). In this pilot study, we compared paired posterior oropharyngeal/tonsillar swabs and oral rinse-and-gargle samples from 10 participants and demonstrated that a similar Neisseria species diversity and number of colonies were isolated from both sample types. Moreover, the proportion of Neisseria colonies that had a decreased susceptibility to azithromycin was similar in the rinse samples compared to the swabs. This pilot study has produced encouraging data that a simple protocol of oral rinse-and-gargle and culture on plates selective for commensal Neisseria with and without a target antimicrobial can be used as a surveillance tool to monitor antimicrobial susceptibility in commensal oropharyngeal Neisseria. Larger studies are required to validate these findings., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2022

25. Antimicrobial susceptibility of commensal Neisseria in a general population and men who have sex with men in Belgium

Author

Laumen, Jolein J.G.E., Van Dijck, Christophe, Abdellati, Said, De Baetselier, Irith, Serrano, Gabriela, Manoharan-Basil, Sheeba Santhini, Bottieau, Emmanuel, Martiny, Delphine, Kenyon, Christopher, Laumen, Jolein J.G.E., Van Dijck, Christophe, Abdellati, Said, De Baetselier, Irith, Serrano, Gabriela, Manoharan-Basil, Sheeba Santhini, Bottieau, Emmanuel, Martiny, Delphine, and Kenyon, Christopher

Abstract

Non-pathogenic Neisseria are a reservoir of antimicrobial resistance genes for pathogenic Neisseria meningitidis and Neisseria gonorrhoeae. Men who have sex with men (MSM) are at risk of co-colonization with resistant non-pathogenic and pathogenic Neisseria. We assessed if the antimicrobial susceptibility of non-pathogenic Neisseria among MSM differs from a general population and if antimicrobial exposure impacts susceptibility. We recruited 96 participants at our center in Belgium: 32 employees, 32 MSM who did not use antibiotics in the previous 6 months, and 32 MSM who did. Oropharyngeal Neisseria were cultured and identified with MALDI-TOF–MS. Minimum inhibitory concentrations for azithromycin, ceftriaxone and ciprofloxacin were determined using E-tests® and compared between groups with non-parametric tests. Non-pathogenic Neisseria from employees as well as MSM were remarkably resistant. Those from MSM were significantly less susceptible than employees to azithromycin and ciprofloxacin (p < 0.0001, p < 0.001), but not ceftriaxone (p = 0.3). Susceptibility did not differ significantly according to recent antimicrobial exposure in MSM. Surveilling antimicrobial susceptibility of non-pathogenic Neisseria may be a sensitive way to assess impact of antimicrobial exposure in a population. The high levels of antimicrobial resistance in this survey indicate that novel resistance determinants may be readily available for future transfer from non-pathogenic to pathogenic Neisseria., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2022

30. Screening of Anorectal and Oropharyngeal Samples Fails to Detect Bacteriophages Infecting Neisseria gonorrhoeae

Author

Laumen, Jolein Gyonne Elise, primary, Abdellati, Saïd, additional, Manoharan-Basil, Sheeba Santhini, additional, Van Dijck, Christophe, additional, Van den Bossche, Dorien, additional, De Baetselier, Irith, additional, de Block, Tessa, additional, Malhotra-Kumar, Surbhi, additional, Soentjes, Patrick, additional, Pirnay, Jean-Paul, additional, Kenyon, Chris, additional, and Merabishvili, Maia, additional

Published
2022
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32. Circulating Isolates of Neisseria mucosa do not Inhibit the Growth of Neisseria gonorrhoeae

Author

Abdellati, Saïd, Laumen, Jolein, Gonzalez, Natalia, Basil, Sheeba, Dijck, Christophe Van, Block, Tessa De, Baetselier, Irith De, Martiny, Delphine, and Kenyon, Chris

Subjects
other
Abstract

We used agar overlay assays to assess if 24 circulating and historical isolates of Neisseria mucosa could inhibit the growth of 28 circulating and historical isolates of N. gonorrhoeae. We found no evidence of inhibition by N. mucosa (n=24). Positive controls Streptococcus pneumoniae and Escherichia coli demonstrated a strong inhibitory effect against the growth of N. gonorrhoeae.

Published
2021

33. Sub-Inhibitory Concentrations of Chlorhexidine Induce Resistance to Chlorhexidine and Decrease Antibiotic Susceptibility in Neisseria gonorrhoeae

Author

Laumen, Jolein G. E., primary, Van Dijck, Christophe, additional, Manoharan-Basil, Sheeba S., additional, Abdellati, Saïd, additional, De Baetselier, Irith, additional, Cuylaerts, Vicky, additional, De Block, Tessa, additional, Van den Bossche, Dorien, additional, Xavier, Basil B., additional, Malhotra-Kumar, Surbhi, additional, and Kenyon, Chris, additional

Published
2021
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37. sj-pdf-1-std-10.1177_09564624211048678 ��� Supplemental Material for Gonococcal bacterial load in PrEP users with Mycoplasma genitalium coinfection

Author

Van Dijck, Christophe, De Baetselier, Irith, Cuylaerts, Vicky, Buyze, Jozefien, Laumen, Jolein, Vuylsteke, Bea, and Kenyon, Chris

Subjects
110309 Infectious Diseases, FOS: Health sciences
Abstract

Supplemental Material, sj-pdf-1-std-10.1177_09564624211048678 for Gonococcal bacterial load in PrEP users with Mycoplasma genitalium coinfection by Christophe Van Dijck, Irith De Baetselier, Vicky Cuylaerts, Jozefien Buyze, Jolein Laumen, Bea Vuylsteke and Chris Kenyon in International Journal of STD & AIDS

Published
2021
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41. WGS of Commensal Neisseria Reveals Acquisition of a New Ribosomal Protection Protein (MsrD) as a Possible Explanation for High Level Azithromycin Resistance in Belgium

Author

de Block, Tessa, primary, Laumen, Jolein Gyonne Elise, additional, Van Dijck, Christophe, additional, Abdellati, Said, additional, De Baetselier, Irith, additional, Manoharan-Basil, Sheeba Santhini, additional, Van den Bossche, Dorien, additional, and Kenyon, Chris, additional

Published
2021
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