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1. Prescribing practices of inhaled corticosteroids for premature infants in the neonatal intensive care unit.

Author

Tang, Monica, Ibrahim, Anna, Laughon, Christopher, Moore, Kaila, Tejada, Angibel, Tran, Dean, Kilpatrick, Ryan, Greenberg, Rachel, Hornik, Christoph, Zimmerman, Kanecia, Laughon, Matthew, Clark, Reese, and Lang, Jason

Subjects
Humans, Infant, Newborn, Intensive Care Units, Neonatal, Administration, Inhalation, Male, Female, Bronchopulmonary Dysplasia, Infant, Premature, Practice Patterns, Physicians, Gestational Age, Adrenal Cortex Hormones, Retrospective Studies, Beclomethasone, Budesonide, Logistic Models, Risk Factors, Fluticasone
Abstract

OBJECTIVE: Despite limited safety and efficacy data, inhaled corticosteroids (ICS) are prescribed to premature infants in the neonatal intensive care unit (NICU). We examined contemporary use and risk factors for ICS use in the NICU. STUDY DESIGN: Infants

Published
2024

2. Patent Ductus Arteriosus in Premature Infants: Clinical Trials and Equipoise

Author

Liguori, Macrina B, Ali, Sanoj KM, Bussman, Neidín, Colaizy, Tarah, Hundscheid, Tim, Phad, Nilkant, Clyman, Ronald, de Boode, Willem-Pieter, de Waal, Koert, El-Khuffash, Afif, Gupta, Samir, and Laughon, Matthew

Subjects
Paediatrics, Biomedical and Clinical Sciences, Infant, Newborn, Infant, Humans, Ductus Arteriosus, Patent, Infant, Premature, Infant, Low Birth Weight, bias, cardiovascular, hemodynamics, neonatology, prematurity, research ethics, study design, symposium summary, Human Movement and Sports Sciences, Paediatrics and Reproductive Medicine, Pediatrics
Published
2023

6. Initial Laparotomy Versus Peritoneal Drainage in Extremely Low Birthweight Infants With Surgical Necrotizing Enterocolitis or Isolated Intestinal Perforation: A Multicenter Randomized Clinical Trial.

Author

Blakely, Martin L, Tyson, Jon E, Lally, Kevin P, Hintz, Susan R, Eggleston, Barry, Stevenson, David K, Besner, Gail E, Das, Abhik, Ohls, Robin K, Truog, William E, Nelin, Leif D, Poindexter, Brenda B, Pedroza, Claudia, Walsh, Michele C, Stoll, Barbara J, Geller, Rachel, Kennedy, Kathleen A, Dimmitt, Reed A, Carlo, Waldemar A, Cotten, C Michael, Laptook, Abbot R, Van Meurs, Krisa P, Calkins, Kara L, Sokol, Gregory M, Sanchez, Pablo J, Wyckoff, Myra H, Patel, Ravi M, Frantz, Ivan D, Shankaran, Seetha, D'Angio, Carl T, Yoder, Bradley A, Bell, Edward F, Watterberg, Kristi L, Martin, Colin A, Harmon, Carroll M, Rice, Henry, Kurkchubasche, Arlet G, Sylvester, Karl, Dunn, James CY, Markel, Troy A, Diesen, Diana L, Bhatia, Amina M, Flake, Alan, Chwals, Walter J, Brown, Rebeccah, Bass, Kathryn D, St Peter, Shawn D, Shanti, Christina M, Pegoli, Walter, Skarda, David, Shilyansky, Joel, Lemon, David G, Mosquera, Ricardo A, Peralta-Carcelen, Myriam, Goldstein, Ricki F, Vohr, Betty R, Purdy, Isabell B, Hines, Abbey C, Maitre, Nathalie L, Heyne, Roy J, DeMauro, Sara B, McGowan, Elisabeth C, Yolton, Kimberly, Kilbride, Howard W, Natarajan, Girija, Yost, Kelley, Winter, Sarah, Colaizy, Tarah T, Laughon, Matthew M, Lakshminrusimha, Satyanarayana, and Higgins, Rosemary D

Subjects
Perinatal Period - Conditions Originating in Perinatal Period, Clinical Research, Infant Mortality, Rare Diseases, Digestive Diseases, Preterm, Low Birth Weight and Health of the Newborn, Pediatric, Clinical Trials and Supportive Activities, Good Health and Well Being, Drainage, Enterocolitis, Necrotizing, Feasibility Studies, Female, Humans, Infant, Extremely Low Birth Weight, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases, Intestinal Perforation, Laparotomy, Male, Neurodevelopmental Disorders, Survival Rate, Treatment Outcome, isolated intestinal perforation, neonatal surgery, premature infant, randomized clinical trial, surgical necrotizing enterocolitis, Eunice Kennedy Shriver National Institute of Child Health, Human Development Neonatal Research Network, Medical and Health Sciences, Surgery
Abstract

ObjectiveThe aim of this study was to determine which initial surgical treatment results in the lowest rate of death or neurodevelopmental impairment (NDI) in premature infants with necrotizing enterocolitis (NEC) or isolated intestinal perforation (IP).Summary background dataThe impact of initial laparotomy versus peritoneal drainage for NEC or IP on the rate of death or NDI in extremely low birth weight infants is unknown.MethodsWe conducted the largest feasible randomized trial in 20 US centers, comparing initial laparotomy versus peritoneal drainage. The primary outcome was a composite of death or NDI at 18 to 22 months corrected age, analyzed using prespecified frequentist and Bayesian approaches.ResultsOf 992 eligible infants, 310 were randomized and 96% had primary outcome assessed. Death or NDI occurred in 69% of infants in the laparotomy group versus 70% with drainage [adjusted relative risk (aRR) 1.0; 95% confidence interval (CI): 0.87-1.14]. A preplanned analysis identified an interaction between preoperative diagnosis and treatment group (P = 0.03). With a preoperative diagnosis of NEC, death or NDI occurred in 69% after laparotomy versus 85% with drainage (aRR 0.81; 95% CI: 0.64-1.04). The Bayesian posterior probability that laparotomy was beneficial (risk difference

Published
2021

7. Umbilical Cord Milking vs Delayed Cord Clamping and Associations with In-Hospital Outcomes among Extremely Premature Infants

Author

Kumbhat, Neha, Eggleston, Barry, Davis, Alexis S, DeMauro, Sara B, Van Meurs, Krisa P, Foglia, Elizabeth E, Lakshminrusimha, Satyan, Walsh, Michele C, Watterberg, Kristi L, Wyckoff, Myra H, Das, Abhik, Handley, Sara C, Network, Generic Database Subcommittee of the National Institute of Child Health and Human Development Neonatal Research, Polin, Richard A, Laptook, R, Keszler, Martin, Hensman, Angelita M, Vieira, Elisa, St. Pierre, Lucille, Hibbs, Anna Maria, Truog, William E, Pallotto, Eugenia K, Parimi, Prabhu S, Gauldin, Cheri, Holmes, Anne, Knutson, Allison, Gaetano, Lisa, Poindexter, Brenda B, Schibler, Kurt, Merhar, Stephanie L, Grisby, Cathy, Kirker, Kristin, Cotten, C Michael, Goldberg, Ronald N, Finkle, Joanne, Fisher, Kimberley A, Laughon, Matthew M, Bose, Carl L, Bernhardt, Janice, Bose, Gennie, Clark, Cindy, Kicklighter, Stephen D, Rhodes-Ryan, Ginger, White, Donna, Carlton, David P, Patel, Ravi M, Loggins, Yvonne, Mackie, Colleen, Bottcher, Diane I, Bremer, Andrew A, Higgins, Rosemary D, Archer, Stephanie Wilson, Sokol, Gregory M, Herron, Dianne E, Tyson, Jon E, Khan, Amir M, Kennedy, Kathleen A, Pedrozza, Claudia, Eason, Elizabeth, Stephens, Emily K, McDavid, Georgia E, Martin, Karen, Hall, Donna, Wright, Sharon L, Sánchez, Pablo J, Nelin, Leif D, Jadcherla, Sudarshan R, Luzader, Patricia, Clark, Erna, Gutentag, Julie, Park, Courtney, Shadd, Julie C, Stein, Melanie, Baugher, Hallie, McCool, Jacqueline, Gantz, Marie G, Bann, Carla M, Wallace, Dennis, Zaterka-Baxter, Kristin M, Gabrio, Jenna, Leblond, David, Auman, Jeanette O'Donnell, Stevenson, David K, Chock, Valerie Y, Ball, M Bethany, Proud, Melinda S, Reichert, Elizabeth N, Williams, R Jordan, Carlo, Waldemar A, Ambalavanan, Namasivayam, Collins, Monica V, Cosby, Shirley S, McNair, Tara, Devaskar, Uday, Garg, Meena, Chanlaw, Teresa, Geller, Rachel, Bell, Edward F, Colaizy, Tarah T, and Ellsbury, Dan L

Subjects
Paediatrics, Biomedical and Clinical Sciences, Prevention, Preterm, Low Birth Weight and Health of the Newborn, Infant Mortality, Clinical Research, Neurosciences, Cardiovascular, Clinical Trials and Supportive Activities, Perinatal Period - Conditions Originating in Perinatal Period, Pediatric, Reproductive health and childbirth, Good Health and Well Being, Cerebral Intraventricular Hemorrhage, Constriction, Female, Gestational Age, Hospital Mortality, Humans, Infant, Extremely Premature, Infant, Newborn, Male, Retrospective Studies, Umbilical Cord, Generic Database Subcommittee of the National Institute of Child Health and Human Development Neonatal Research Network, Neonatal Research Network, intraventricular hemorrhage, placental transfusion, Human Movement and Sports Sciences, Paediatrics and Reproductive Medicine, Pediatrics
Abstract

ObjectiveTo compare in-hospital outcomes after umbilical cord milking vs delayed cord clamping among infants

Published
2021

8. Early-Life Outcomes in Relation to Social Determinants of Health for Children Born Extremely Preterm

Author

Jobe, Alan H., Caplan, Michael S., Polin, Richard A., Laptook, Abbot R., Keszler, Martin, Hensman, Angelita M., Alksninis, Barbara, Bishop, Carmena, Burke, Robert T., Caskey, Melinda, Hoffman, Laurie, Johnson, Katharine, Keszler, Mary Lenore, Knoll, Andrea M., Lamberson, Vita, Leach, Teresa M., Little, Emilee, McGowan, Elisabeth C., Stephens, Bonnie E., Vieira, Elisa, St. Pierre, Lucille, Ventura, Suzy, Watson, Victoria E., Hibbs, Anna Maria, Walsh, Michele C., Wilson-Costello, Deanne E., Newman, Nancy S., Bhola, Monika, Payne, Allison H., Siner, Bonnie S., Yalcinkaya, Gulgun, Truog, William E., Pallotto, Eugenia K., Kilbride, Howard W., Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Scott, Allison, Parimi, Prabhu S., Gaetano, Lisa, Poindexter, Brenda B., Schibler, Kurt, Kallapur, Suhas G., Donovan, Edward F., Merhar, Stephanie, Grisby, Cathy, Yolton, Kimberly, Alexander, Barbara, Beiersdorfer, Traci, Bridges, Kate, Cahill, Tanya E., Dudley, Juanita, Fischer, Estelle E., Gratton, Teresa L., Hayes, Devan, Hessling, Jody, Jackson, Lenora D., Kirker, Kristin, Mincey, Holly L., Muthig, Greg, Stacey, Sara, Steichen, Jean J., Tepe, Stacey, Thompson, Julia, Wuertz, Sandra, Cotten, C. Michael, Goldberg, Ronald N., Goldstein, Ricki F., Malcolm, William F., Mago-Shah, Deesha, Ashley, Patricia L., Finkle, Joanne, Auten, Kathy J., Fisher, Kimberley A., Grimes, Sandra, Gustafson, Kathryn E., Lohmeyer, Melody B., Laughon, Matthew M., Bose, Carl L., Bernhardt, Janice, Bose, Gennie, Clark, Cindy, Talbert, Jennifer, Warner, Diane, Trembath, Andrea, O'Shea, T. Michael, Wereszczak, Janice, Kicklighter, Stephen D., Rhodes-Ryan, Ginger, White, Donna, Patel, Ravi M., Carlton, David P., Stoll, Barbara J., Hale, Ellen C., Loggins, Yvonne C., Adams-Chapman, Ira, Blackwelder, Ann, Bottcher, Diane I., Carter, Sheena L., Kendrick-Allwood, Salathiel, Laursen, Judith, LaRossa, Maureen Mulligan, Mackie, Colleen, Sanders, Amy, Seabrook, Irma, Smikle, Gloria, Wineski, Lynn C., Higgins, Rosemary D., Bremer, Andrew A., Archer, Stephanie Wilson, Sokol, Gregory M., Dusick, Anna M., Papile, Lu Ann, Gunn, Susan, Hamer, Faithe, Harmon, Heidi M., Herron, Dianne E., Hines, Abbey C., Lytle, Carolyn, Miller, Lucy C., Minnich, Heike M., Richard, Leslie, Smiley, Lucy, Wilson, Leslie Dawn, Tyson, Jon E., Kennedy, Kathleen A., Khan, Amir M., Duncan, Andrea, Mosquera, Ricardo, Stephens, Emily K., McDavid, Georgia E., Alaniz, Nora I., Allain, Elizabeth, Arldt-McAlister, Julie, Burson, Katrina, Dempsey, Allison G., Eason, Elizabeth, Evans, Patricia W., Garcia, Carmen, Green, Charles, Hall, Donna, Harris, Beverly Foley, Jiminez, Margarita, John, Janice, Jones, Patrick M., Lillie, M. Layne, Lis, Anna E., Martin, Karen, Martin, Sara C., Mason, Carrie M., McKee, Shannon, Morris, Brenda H., Rennie, Kimberly, Rodgers, Shawna, Siddiki, Saba Khan, Simmons, Maegan C., Sperry, Daniel, Pierce Tate, Patti L., Wright, Sharon L., Sánchez, Pablo J., Nelin, Leif D., Jadcherla, Sudarshan R., Slaughter, Jonathan L., Yeates, Keith O., Keim, Sarah, Maitre, Nathalie L., Timan, Christopher J., Luzader, Patricia, Clark, Erna, Fortney, Christine A., Gutentag, Julie, Park, Courtney, Shadd, Julie, Sullivan, Margaret, Stein, Melanie, Nelin, Mary Ann, Newton, Julia, Small, Kristi, Burkhardt, Stephanie, Purnell, Jessica, Pietruszewski, Lindsay, Levengood, Katelyn, Batterson, Nancy, Morehead, Pamela, Carey, Helen, Yoseff-Salameh, Lina, Sullivan, Rox Ann, Hague, Cole, Grothause, Jennifer, Fearns, Erin, Fowler, Aubrey, Notestine, Jennifer, Tonneman, Jill, Hay, Krystal, Chao, Michelle, Warnimont, Kyrstin, Marzec, Laura, Miller, Bethany, Beckford, Demi R., Baugher, Hallie, DeSantis, Brittany, Hanlon, Cory, McCool, Jacqueline, Das, Abhik, Gantz, Marie G., Bann, Carla M., Wallace, Dennis, Crawford, Margaret M., Gabrio, Jenna, Leblond, David, Newman, Jamie E., Petrie Huitema, Carolyn M., O'Donnell Auman, Jeanette, Poole, W. Kenneth, Zaterka-Baxter, Kristin M., Van Meurs, Krisa P., Chock, Valerie Y., Stevenson, David K., Adams, Marian M., Ball, M. Bethany, Bentley, Barbara, Bruno, Elizabeth, Davis, Alexis S., Elena DeAnda, Maria, DeBattista, Anne M., Huffman, Lynne C., Ismael, Magdy, Kohn, Jean G., Krueger, Casey, Lowe, Janice, Lucash, Ryan E., Palmquist, Andrew W., Patel, Jessica, Proud, Melinda S., Reichert, Elizabeth N., John, Nicholas H. St., Sivakumar, Dharshi, Taylor, Heather L., Wager, Natalie, Williams, R. Jordan, Weiss, Hali, Frantz, Ivan D., III, Fiascone, John M., MacKinnon, Brenda L., Furey, Anne, Nylen, Ellen, Church, Paige T., Sibley, Cecelia E., Brussa, Ana K., Carlo, Waldemar A., Ambalavanan, Namasivayam, Peralta-Carcelen, Myriam, Nelson, Kathleen G., Bailey, Kirstin J., Biasini, Fred J., Chopko, Stephanie A., Collins, Monica V., Cosby, Shirley S., Johnston, Kristen C., Moses, Mary Beth, Patterson, Cryshelle S., Phillips, Vivien A., Preskitt, Julie, Rector, Richard V., Whitley, Sally, Devaskar, Uday, Garg, Meena, Purdy, Isabell B., Chanlaw, Teresa, Geller, Rachel, Finer, Neil N., Vaucher, Yvonne E., Kaegi, David, Rasmussen, Maynard R., Arnell, Kathy, Demetrio, Clarence, Fuller, Martha G., Rich, Wade, Bell, Edward F., Colaizy, Tarah T., Widness, John A., Brumbaugh, Jane E., Acarregui, Michael J., Johnson, Karen J., Eastman, Diane L., Goeke, Claire A., Schmelzel, Mendi L., Walker, Jacky R., Baack, Michelle L., Hogden, Laurie A., Broadbent, Megan, Elenkiwich, Chelsey, Henning, Megan M., Van Muyden, Sarah, Ellsbury, Dan L., Campbell, Donia B., Tud, Tracy L., Duara, Shahnaz, Bauer, Charles R., Everett-Thomas, Ruth, Fajardo-Hiriart, Sylvia, Rigaud, Arielle, Calejo, Maria, Frade Eguaras, Silvia M., Berkowits, Michelle Harwood, Garcia, Andrea, Pierre, Helina, Stoerger, Alexandra, Watterberg, Kristi L., Fuller, Janell, Ohls, Robin K., Beauman, Sandra Sundquist, Lacy, Conra Backstrom, Duncan, Andrea F., Hanson, Mary, Hartenberger, Carol, Kuan, Elizabeth, Lowe, Jean R., Thomson, Rebecca A., DeMauro, Sara B., Eichenwald, Eric C., Schmidt, Barbara, Kirpalani, Haresh, Chaudhary, Aasma S., Abbasi, Soraya, Mancini, Toni, Catts, Christine, Cook, Noah, Cucinotta, Dara M., Bernbaum, Judy C., Gerdes, Marsha, Ghavam, Sarvin, Hurt, Hallam, Snyder, Jonathan, Vangala, Saritha, Ziolkowski, Kristina, D'Angio, Carl T., Phelps, Dale L., Guillet, Ronnie, Myers, Gary J., Andrews-Hartley, Michelle, Johnson, Julie Babish, Binion, Kyle, Bowman, Melissa, Boylin, Elizabeth, Burnell, Erica, Coleman, Kelly R., Fallone, Cait, Farooq, Osman, Hunn, Julianne, Hust, Diane, Jensen, Rosemary L., Jones, Rachel, Kachelmeyer, Jennifer, Kushner, Emily, Maffett, Deanna, McKee, Kimberly G., Merzbach, Joan, Orme, Constance, Prinzing, Diane, Reubens, Linda J., Rochez, Daisy, Rowan, Mary, Sabaratnam, Premini, Scorsone, Ann Marie, Wadkins, Holly I.M., Yost, Kelley, Zwetsch, Lauren, Lakshminrusimha, Satyan, Reynolds, Anne Marie, Sacilowski, Michael G., Guilford, Stephanie, Li, Emily, Williams, Ashley, Zorn, William A., Wyckoff, Myra H., Brion, Luc P., Salhab, Walid A., Rosenfeld, Charles R., Heyne, Roy J., Vasil, Diana M., Adams, Sally S., Chen, Lijun, De Leon, Maria M., Eubanks, Francis, Guzman, Alicia, Hensley, Gaynelle, Heyne, Elizabeth T., Lee, Lizette E., Leps, Melissa H., Madden, Linda A., McDougald, E. Rebecca, Miller, Nancy A., Morgan, Janet S., Pavageau, Lara, Sepulveda, Pollieanna, Tolentino-Plata, Kristine, Boatman, Cathy Twell, Vera, Azucena, Waterbury, Jillian, Yoder, Bradley A., Baserga, Mariana, Faix, Roger G., Winter, Sarah, Minton, Stephen D., Sheffield, Mark J., Rau, Carrie A., Baker, Shawna, Bird, Karie, Burnett, Jill, Christensen, Susan, Cole-Bledsoe, Laura, Davis, Brandy, Elmont, Jennifer O., Jensen, Jennifer J., Loertscher, Manndi C., Jordan, Jamie, Marchant, Trisha, Maxson, Earl, McGrath, Kandace M., Osborne, Karen A., Parry, D. Melody, Reich, Brixen A., Schaefer, Susan T., Spencer, Cynthia, Steffen, Michael, Tice, Katherine, Weaver-Lewis, Kimberlee, Woodbury, Kathryn D., Zanetti, Karen, Dillard, Robert G., Washburn, Lisa K., Jackson, Barbara G., Peters, Nancy, Chiu, Korinne, Allred, Deborah Evans, Goldstein, Donald J., Halfond, Raquel, Peterson, Carroll, Waldrep, Ellen L., Welch, Cherrie D., Morris, Melissa Whalen, Hounshell, Gail Wiley, Shankaran, Seetha, Sood, Beena G., Natarajan, Girija, Pappas, Athina, Abramczyk, Katherine, Agarwal, Prashant, Bajaj, Monika, Bara, Rebecca, Billian, Elizabeth, Chawla, Sanjay, Childs, Kirsten, De Jesus, Lilia C., Driscoll, Debra, February, Melissa, Goldston, Laura A., Johnson, Mary E., Muran, Geraldine, Panaitescu, Bogdan, Prentiss, Jeannette E., White, Diane, Woldt, Eunice, Barks, John, Wiggins, Stephanie A., Christensen, Mary K., Carlson, Martha D., Ehrenkranz, Richard A., Jacobs, Harris, Butler, Christine G., Cervone, Patricia, Greisman, Sheila, Konstantino, Monica, Poulsen, JoAnn, Taft, Janet, Williams, Joanne, Romano, Elaine, Vohr, Betty R., Travers, Colm P., and Hintz, Susan R.

Published
2023
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9. Drugs Used to Treat Pediatric Emergencies

Author

Shenoi, Rohit P, Timm, Nathan, Jones, Bridgette, Neville, Kathleen, Foster, Jennifer, Houck, Connie, Laughon, Matthew, Paul, Ian, Reigart, Routt J, Sullivan, Janice, van den Anker, John, Wright, Joseph, Adirim, Terry, Callahan, James, Agus, Michael, Gonzalez del Rey, Javier, Gross, Toni, Joseph, Madeline, Lane, Natalie, Lee, Lois, Mack, Elizabeth, Mahajan, Prashant, Marin, Jennifer, and Mazor, Suzan

Subjects
Emergency Care, Heart Disease, Pediatric, Cardiovascular, Child, Drug Therapy, Emergencies, Emergency Medical Services, Emergency Service, Hospital, Humans, Pediatrics, COMMITTEE ON DRUGS, COMMITTEE ON PEDIATRIC EMERGENCY MEDICINE, Medical and Health Sciences, Psychology and Cognitive Sciences
Abstract

This clinical report is a revision of "Preparing for Pediatric Emergencies: Drugs to Consider." It updates the list, indications, and dosages of medications used to treat pediatric emergencies in the prehospital, pediatric clinic, and emergency department settings. Although it is not an all-inclusive list of medications that may be used in all emergencies, this resource will be helpful when treating a vast majority of pediatric medical emergencies. Dosage recommendations are consistent with current emergency references such as the Advanced Pediatric Life Support and Pediatric Advanced Life Support textbooks and American Heart Association resuscitation guidelines.

Published
2020

14. Pharmacokinetics of Dexamethasone in Children and Adolescents with Obesity.

Author

Wen, Jiali, McCann, Sean, Balevic, Stephen J., Muller, William J., Hornik, Chi D., Autmizguine, Julie, Anderson, Sarah G., Payne, Elizabeth H., Turdalieva, Sitora, Gonzalez, Daniel, Benjamin, Daniel K., Zimmerman, Kanecia, Kennel, Phyllis, Alderman, Cheryl, Sund, Zoe, Opel, Kylie, Beci, Rose, Hornik, Chi Dang, Kearns, Gregory L., and Laughon, Matthew

Subjects
BIOLOGICAL models, RESEARCH funding, STATISTICAL significance, BODY weight, DESCRIPTIVE statistics, DOSE-effect relationship in pharmacology, SIMULATION methods in education, CHILDHOOD obesity, DATA analysis software, DEXAMETHASONE, GLUCOCORTICOIDS, TIME, CHILDREN
Abstract

Dexamethasone is a synthetic glucocorticoid approved for treating disorders of various organ systems in both adult and pediatric populations. Currently, approved pediatric dosing recommendations are weight‐based, but it is unknown whether differences in dexamethasone drug disposition and exposure exist for children with obesity. This study aimed to develop a population pharmacokinetic (PopPK) model for dexamethasone with data collected from children with obesity. Dexamethasone was given as either IV or oral/enteral administration, and a salt factor correction was used for dexamethasone sodium phosphate injection. A PopPK analysis using dexamethasone plasma concentration versus time was performed using the software NONMEM. A virtual population of 1000 children with obesity across three age groups was generated for dosing simulations. Data from 59 study participants with 82 PK plasma samples were used in the PopPK analysis. A one‐compartment model with first‐order absorption and the inclusion of total body weight as a covariate characterized the data. No other covariates were included in the PopPK model. Single and multiple IV dose(s) of 0.5 and 1 mg/kg every 8 h resulted in 68% or more of virtual children with obesity attaining simulated exposures that were within exposure ranges previously reported in adult studies. In conclusion, this was the first study to characterize dexamethasone's PopPK in children with obesity. Simulation results suggest that virtual children with obesity receiving oral doses of 0.5 and 1 mg/kg had generally comparable dexamethasone exposures as adult estimates. Additional studies are needed to characterize the dexamethasone's target exposure in children. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Correlating Severity of Pulmonary Hypertension by Echocardiogram with Mortality in Premature Infants with Bronchopulmonary Dysplasia.

Author

Torok, Rachel D., Gardner, Robert A., Barker, Piers C.A., McCrary, Andrew W., Li, Jennifer S., Hornik, Christoph P., Laughon, Matthew M., and Jackson, Wesley M.

Subjects
PULMONARY hypertension diagnosis, RESEARCH funding, PULMONARY hypertension, BRONCHOPULMONARY dysplasia, PREMATURE infant diseases, SEVERITY of illness index, DESCRIPTIVE statistics, DISCHARGE planning, MANN Whitney U Test, KAPLAN-Meier estimator, ECHOCARDIOGRAPHY, CARDIOLOGISTS, DISEASE complications, CHILDREN
Abstract

Objective Bronchopulmonary dysplasia (BPD) is the most common complication of preterm birth. Infants with BPD are at increased risk for pulmonary hypertension (PH). Cardiac catheterization is the gold standard for diagnosing PH, but cardiac catheterization is challenging to perform in small, sick, premature infants. The utility of echocardiography for diagnosing PH and predicting outcomes in extremely premature infants has not been clearly defined. Therefore, we sought to use predefined criteria to diagnose PH by echocardiogram and relate PH severity to mortality in extremely premature infants with BPD. Study Design Echocardiograms from 46 infants born ≤28 weeks' postmenstrual age with a diagnosis of BPD were assessed for PH by three pediatric cardiologists using predefined criteria, and survival times among categories of PH patients were compared. A total of 458 echocardiograms were reviewed, and 15 (33%) patients were found to have at least moderate PH. Patients with at least moderate PH had similar demographic characteristics to those with no/mild PH. Results Ninety percent of infants without moderate to severe PH survived to hospital discharge, compared with 67% of infants with at least moderate PH (p = 0.048). Patients with severe PH had decreased survival to hospital discharge (38%) compared with moderate (100%) and no/mild PH (90%) groups. Kaplan–Meier survival curves also differed among PH severity groups (Wilcoxon p < 0.001). Conclusion Using predefined criteria for PH, premature infants with BPD can be stratified into PH severity categories. Patients diagnosed with severe PH by echocardiogram have significantly reduced survival. Key Points A composite score definition of PH by echocardiogram showed high inter- and intrarater reliability. Infants with severe PH by echocardiogram had decreased survival rates. Early diagnosis of PH by echocardiogram dictates treatment which may improve outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Safety of sildenafil in extremely premature infants: a phase I trial

Author

Jackson, Wesley, Gonzalez, Daniel, Smith, P. Brian, Ambalavanan, Namasivayam, Atz, Andrew M., Sokol, Gregory M., Hornik, Chi D., Stewart, Dan, Mundakel, Gratias, Poindexter, Brenda B., Ahlfeld, Shawn K., Mills, Mary, Cohen-Wolkowiez, Michael, Martz, Karen, Hornik, Christoph P., and Laughon, Matthew M.

Published
2022
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17. Delivery Room Resuscitation and Short-Term Outcomes in Moderately Preterm Infants

Author

Bajaj, Monika, Natarajan, Girija, Shankaran, Seetha, Wyckoff, Myra, Laptook, R, Bell, Edward F, Stoll, Barbara J, Carlo, Waldemar A, Vohr, Betty R, Saha, Shampa, Van Meurs, Krisa P, Sanchez, Pablo J, D'Angio, Carl T, Higgins, Rosemary D, Das, Abhik, Newman, Nancy, Walsh, Michele C, Network, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research, Polin, Richard A, Keszler, Martin, Hensman, Angelita M, Vieira, Elisa, Hibbs, Anna Marie, Siner, Bonnie S, Truog, William E, Pallotto, Eugenia K, Kilbride, Howard W, Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Poindexter, Brenda B, Schibler, Kurt, Kallapur, Suhas G, Grisby, Cathy, Alexander, Barbara, Fischer, Estelle E, Jackson, Lenora, Kirker, Kristin, Jennings, Jennifer, Wuertz, Sandra, Muthig, Greg, Cotten, C Michael, Goldberg, Ronald N, Finkle, Joanne, Fisher, Kimberley A, Laughon, Matthew M, Bose, Carl L, Bernhardt, Janice, Clark, Cindy, Carlton, David P, Hale, Ellen C, Loggins, Yvonne, Bottcher, Diane I, Archer, Stephanie Wilson, Sokol, Greg, Herron, Dianne E, Nelin, Leif D, Jadcherla, Sudarshan R, Luzader, Patricia, Parikh, Nehal A, Nist, Marliese Dion, Fuller, Jennifer, Gutentag, Julie, Jones, Marissa E, McGregor, Sarah, Rodgers, Elizabeth, Ulloa, Jodi A, Wolfe, Tara, Wallace, Dennis, Zaterka-Baxter, Kristin M, Crawford, Margaret, Gabrio, Jenna, Kandefer, Sarah, Auman, Jeanette O'Donnell, Stevenson, David K, Ball, M Bethany, Proud, Melinda S, Ambalavanan, Namasivayam, Collins, Monica V, Cosby, Shirley S, Devaskar, Uday, Garg, Meena, Chanlaw, Teresa, Geller, Rachel, Colaizy, Tarah T, Ellsbury, Dan L, Brumbaugh, Jane E, Johnson, Karen J, Campbell, Donia B, Walker, Jacky R, Watterberg, Kristi L, Ohls, Robin K, Lacy, Conra Backstrom, Beauman, Sandy Sundquist, Hartenberger, Carol, Schmidt, Barbara, Kirpalani, Haresh, DeMauro, Sara B, Cook, Noah, and Chaudhary, Aasma S

Subjects
Paediatrics, Biomedical and Clinical Sciences, Preterm, Low Birth Weight and Health of the Newborn, Pediatric, Perinatal Period - Conditions Originating in Perinatal Period, Infant Mortality, Lung, Clinical Research, Reproductive health and childbirth, Good Health and Well Being, Cardiopulmonary Resuscitation, Continuous Positive Airway Pressure, Delivery Rooms, Female, Humans, Infant, Newborn, Infant, Premature, Infant, Small for Gestational Age, Intubation, Intratracheal, Male, Outcome Assessment, Health Care, Oxygen Inhalation Therapy, Prospective Studies, Registries, Risk Factors, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, CPR, delivery room, endotracheal intubation, moderate Preterm, oxygen, resuscitation, Human Movement and Sports Sciences, Paediatrics and Reproductive Medicine, Pediatrics
Abstract

ObjectivesTo describe the frequency and extent of delivery room resuscitation and evaluate the association of delivery room resuscitation with neonatal outcomes in moderately preterm (MPT) infants.Study designThis was an observational cohort study of MPT infants delivered at 290/7 to 336/7 weeks' gestational age (GA) enrolled in the Neonatal Research Network MPT registry. Infants were categorized into 5 groups based on the highest level of delivery room intervention: routine care, oxygen and/or continuous positive airway pressure, bag and mask ventilation, endotracheal intubation, and cardiopulmonary resuscitation including chest compressions and/or epinephrine use. The association of antepartum and intrapartum risk factors and discharge outcomes with the intensity of resuscitation was evaluated.ResultsOf 7014 included infants, 1684 (24.0%) received routine care and no additional resuscitation, 2279 (32.5%) received oxygen or continuous positive airway pressure, 1831 (26.1%) received bag and mask ventilation, 1034 (14.7%) underwent endotracheal intubation, and 186 (2.7%) received cardiopulmonary resuscitation. Among the antepartum and intrapartum factors, increasing GA, any exposure to antenatal steroids and prolonged rupture of membranes decreased the likelihood of receipt of all levels of resuscitation. Infants who were small for GA (SGA) had increased risk of delivery room resuscitation. Among the neonatal outcomes, respiratory support at 28 days, days to full oral feeds and length of stay were significantly associated with the intensity of delivery room resuscitation. Higher intensity of resuscitation was associated with increased risk of mortality.ConclusionsThe majority of MPT infants receive some level of delivery room resuscitation. Increased intensity of delivery room interventions was associated with prolonged respiratory and nutritional support, increased mortality, and a longer length of stay.

Published
2018

18. Admission Temperature and Associated Mortality and Morbidity among Moderately and Extremely Preterm Infants

Author

Laptook, R, Bell, Edward F, Shankaran, Seetha, Boghossian, Nansi S, Wyckoff, Myra H, Kandefer, Sarah, Walsh, Michele, Saha, Shampa, Higgins, Rosemary, Network, Generic and Moderate Preterm Subcommittees of the NICHD Neonatal Research, Polin, Richard A, Keszler, Martin, Vohr, Betty R, Hensman, Angelita M, Vieira, Elisa, Little, Emilee, Fanaroff, Avroy A, Hibbs, Anna Marie, Newman, Nancy S, Siner, Bonnie S, Truog, William E, Pallotto, Eugenia K, Kilbride, Howard W, Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Schibler, Kurt, Kallapur, Suhas G, Grisby, Cathy, Alexander, Barbara, Fischer, Estelle E, Jackson, Lenora, Kirker, Kristin, Jennings, Jennifer, Wuertz, Sandra, Muthig, Greg, Donovan, Edward F, Hessling, Jody, Mersmann, Marcia Worley, Mincey, Holly L, Cotten, C Michael, Goldberg, Ronald N, Finkle, Joanne, Fisher, Kimberley A, Auten, Kathy J, Laughon, Matthew M, Bose, Carl L, Bernhardt, Janice, Clark, Cindy, Stoll, Barbara J, Carlton, David P, Hale, Ellen C, Loggins, Yvonne, Bottcher, Diane I, Archer, Stephanie Wilson, Wright, Linda L, McClure, Elizabeth M, Poindexter, Brenda B, Sokol, Gregory M, Herron, Dianne E, Lemons, James A, Appel, Diana D, Miller, Lucy C, Sanchez, Pablo J, Nelin, Leif D, Jadcherla, Sudarshan R, Luzader, Patricia, Parikh, Nehal A, Nist, Marliese Dion, Fuller, Jennifer, Gutentag, Julie, Jones, Marissa E, McGregor, Sarah, Rodgers, Elizabeth, Ulloa, Jodi A, Wolfe, Tara, Das, Abhik, Wallace, Dennis, Poole, W Kenneth, Zaterka-Baxter, Kristin M, Crawford, Margaret, Gabrio, Jenna, Auman, Jeanette O'Donnell, Huitema, Carolyn Petrie, Hastings, Betty K, Van Meurs, Krisa P, Stevenson, David K, Ball, M Bethany, Proud, Melinda S, Carlo, Waldemar A, Ambalavanan, Namasivayam, Collins, Monica V, Cosby, Shirley S, Devaskar, Uday, Garg, Meena, Chanlaw, Teresa, Geller, Rachel, Colaizy, Tarah T, Ellsbury, Dan L, and Brumbaugh, Jane E

Subjects
Paediatrics, Biomedical and Clinical Sciences, Perinatal Period - Conditions Originating in Perinatal Period, Infant Mortality, Pediatric, Clinical Research, Preterm, Low Birth Weight and Health of the Newborn, Reproductive health and childbirth, Good Health and Well Being, Body Temperature, Female, Fever, Hospital Mortality, Humans, Hypothermia, Infant, Extremely Premature, Infant, Newborn, Infant, Premature, Diseases, Intensive Care Units, Neonatal, Logistic Models, Male, Patient Admission, Risk Factors, United States, Generic and Moderate Preterm Subcommittees of the NICHD Neonatal Research Network, hyperthermia, hypothermia, prematurity, survival, Human Movement and Sports Sciences, Paediatrics and Reproductive Medicine, Pediatrics
Abstract

ObjectiveTo evaluate the temperature distribution among moderately preterm (MPT, 29-33 weeks) and extremely preterm (EPT, 37.5°C (4.2% vs 6.2%). For EPT infants in 2012-2013 compared with 2002-2003, the percentage of temperatures between 36.5°C and 37.5°C more than doubled and the percentage of temperatures >37.5°C more than tripled. Admission temperature was inversely associated with in-hospital mortality.ConclusionsLow and high admission temperatures are more frequent among EPT than MPT infants. Compared with a decade earlier, fewer EPT infants experience low admission temperatures but more have elevated temperatures. In spite of a change in distribution of NICU admission temperature, an inverse association between temperature and mortality risk persists.

Published
2018

21. Umbilical Cord Milking vs Delayed Cord Clamping and Associations with In-Hospital Outcomes among Extremely Premature Infants

Author

Polin, Richard A., Laptook, Abbot R., Keszler, Martin, Hensman, Angelita M., Vieira, Elisa, Pierre, Lucille St., Hibbs, Anna Maria, Truog, William E., Pallotto, Eugenia K., Parimi, Prabhu S., Gauldin, Cheri, Holmes, Anne, Knutson, Allison, Gaetano, Lisa, Poindexter, Brenda B., Schibler, Kurt, Merhar, Stephanie L., Grisby, Cathy, Kirker, Kristin, Cotten, C. Michael, Goldberg, Ronald N., Finkle, Joanne, Fisher, Kimberley A., Laughon, Matthew M., Bose, Carl L., Bernhardt, Janice, Bose, Gennie, Clark, Cindy, Kicklighter, Stephen D., Rhodes-Ryan, Ginger, White, Donna, Carlton, David P., Patel, Ravi M., Loggins, Yvonne, Mackie, Colleen, Bottcher, Diane I., Bremer, Andrew A., Higgins, Rosemary D., Wilson Archer, Stephanie, Sokol, Gregory M., Herron, Dianne E., Tyson, Jon E., Khan, Amir M., Kennedy, Kathleen A., Pedrozza, Claudia, Eason, Elizabeth, Stephens, Emily K., McDavid, Georgia E., Martin, Karen, Hall, Donna, Wright, Sharon L., Sánchez, Pablo J., Nelin, Leif D., Jadcherla, Sudarshan R., Luzader, Patricia, Clark, Erna, Gutentag, Julie, Park, Courtney, Shadd, Julie C., Stein, Melanie, Baugher, Hallie, McCool, Jacqueline, Gantz, Marie G., Bann, Carla M., Wallace, Dennis, Zaterka-Baxter, Kristin M., Gabrio, Jenna, Leblond, David, Auman, Jeanette O'Donnell, Stevenson, David K., Chock, Valerie Y., Ball, M. Bethany, Proud, Melinda S., Reichert, Elizabeth N., Williams, R. Jordan, Carlo, Waldemar A., Ambalavanan, Namasivayam, Collins, Monica V., Cosby, Shirley S., McNair, Tara, Devaskar, Uday, Garg, Meena, Chanlaw, Teresa, Geller, Rachel, Bell, Edward F., Colaizy, Tarah T., Ellsbury, Dan L., Baack, Michelle L., Johnson, Karen J., Schmelzel, Mendi L., Walker, Jacky R., Goeke, Claire A., Tud, Tracy L., Elenkiwich, Chelsey, Henning, Megan M., Broadbent, Megan, Hogden, Laurie A., Brumbaugh, Jane E., Klein, Jonathan M., Dagle, John M., Fuller, Janell, Ohls, Robin K., Sundquist Beauman, Sandra, Backstrom Lacy, Conra, Hartenberger, Carol, Hanson, Mary, Kuan, Elizabeth, Eichenwald, Eric C., Schmidt, Barbara, Kirpalani, Haresh, Abbasi, Soraya, Catts, Christine, Chaudhary, Aasma S., Ghavam, Sarvin, Mancini, Toni, Snyder, Jonathan, D'Angio, Carl T., Guillet, Ronnie, Reynolds, Anne Marie, Wadkins, Holly I.M., Sacilowski, Michael G., Rowan, Mary, Jensen, Rosemary L., Maffett, Deanna, Prinzing, Diane, Scorsone, Ann Marie, Binion, Kyle, Guilford, Stephanie, Orme, Constance, Sabaratnam, Premini, Daisy Rochez, Li, Emily, Donato, Jennifer, Lakshminrusimha, Satyan, Jones, Rachel, Brion, Luc P., DeLeon, Maria M., Eubanks, Frances, Sepulvida, Pollieanna, Vasil, Diana M., Yoder, Bradley A., Baserga, Mariana, Minton, Stephen D., Sheffield, Mark J., Rau, Carrie A., Burnett, Jill, Davis, Brandy, Christensen, Susan, Loertscher, Manndi C., Marchant, Trisha, Maxson, Earl, McGrath, Kandace, Elmont, Jennifer O., Parry, Melody, Schaefer, Susan T., Weaver-Lewis, Kimberlee, Woodbury, Kathryn D., Shankaran, Seetha, Natarajan, Girija, Chawla, Sanjay, Childs, Kirsten, Panaitescu, Bogdan, Barks, John, White, Diane F., Kumbhat, Neha, Eggleston, Barry, Davis, Alexis S., DeMauro, Sara B., Van Meurs, Krisa P., Foglia, Elizabeth E., Walsh, Michele C., Watterberg, Kristi L., Wyckoff, Myra H., Das, Abhik, and Handley, Sara C.

Published
2021
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23. Postdiscontinuation Antibiotic Exposure in Hospitalized Infants at Risk for Late-onset Sepsis in the Neonatal Intensive Care Unit

Author

Wade, Kelly C., Greenberg, Rachel G., Benjamin, Daniel K., Chen, Lydia Li-Hui, Vo, Brandon, Ang, Berwyn Liselle, Boutzoukas, Angelique, Zimmerman, Kanecia, Clark, Reese H., Cohen-Wolkowiez, Michael, Le, Jennifer, Hornik, Christoph, Kennel, Phyllis, Beci, Rose, Hornik, Chi Dang, Kearns, Gregory L., Laughon, Matthew, Paul, Ian M., Sullivan, Janice, Delmore, Paula, Taylor-Zapata, Perdita, Lee, June, Anand, Ravinder, Sharma, Gaurav, Simone, Gina, Kaneshige, Kim, Taylor, Lawrence, and Green, Thomas

Published
2024
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25. Limitations of Conventional Magnetic Resonance Imaging as a Predictor of Death or Disability Following Neonatal Hypoxic–Ischemic Encephalopathy in the Late Hypothermia Trial

Author

Caplan, Michael S., Polin, Richard A., Keszler, Martin, Oh, William, Vohr, Betty R., McGowan, Elizabeth C., Alksninis, Barbara, Basso, Kristin, Bliss, Joseph, Bishop, Carmena, Burke, Robert T., Cashore, William, Caskey, Melinda, Gingras, Dan, Guerina, Nicholas, Johnson, Katharine, Keszler, Mary Lenore, Knoll, Andrea M., Leach, Theresa M., Leonard, Martha R., Little, Emilee, Stephens, Bonnie E., Vieira, Elisa, Watson, Victoria E., Hibbs, Anna Maria, Wilson-Costello, Deanne E., Newman, Nancy S., Batton, Beau, Bhola, Monika, Di Fiore, Juliann M., Friedman, Harriet G., Siner, Bonnie S., Stork, Eileen K., Yalcinkaya, Gulgun, Zadell, Arlene, Pallotto, Eugenia K., Kilbride, Howard W., Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Knutson, Allison, Schibler, Kurt, Yolton, Kimberly, Grisby, Cathy, Gratton, Teresa L., Merhar, Stephanie, Wuertz, Sandra, Cotten, C. Michael, Fisher, Kimberley A., Grimes, Sandra, Finkle, Joanne, Goldstein, Ricki F., Gustafson, Kathryn E., Malcolm, William F., Ashley, Patricia L., Auten, Kathy J., Lohmeyer, Melody B., Laughon, Matthew M., Bose, Carl L., Bernhardt, Janice, Clark, Cindy, Warner, Diane D., Wereszcsak, Janice, Aliaga, Sofia, Carlton, David P., Stoll, Barbara J., Hale, Ellen C., Loggins, Yvonne, Bottcher, Diane I., Mackie, Colleen, LaRossa, Maureen Mulligan, Adams-Chapman, Ira, Wineski, Lynn C., Carter, Sheena L., Higgins, Rosemary D., Archer, Stephanie Wilson, Harmon, Heidi M., Papile, Lu-Ann, Dusick, Anna M., Gunn, Susan, Herron, Dianne E., Hines, Abbey C., Kardatzke, Darlene, Lytle, Carolyn, Minnich, Heike M., Richard, Leslie, Smiley, Lucy C., Wilson, Leslie Dawn, Kennedy, Kathleen A., Allain, Elizabeth, Mason, Carrie M., Arldt-McAlister, Julie, Burson, Katrina, Dempsey, Allison G., Duncan, Andrea F., Evans, Patricia W., Garcia, Carmen, Green, Charles E., Jimenez, Margarita, John, Janice, Jones, Patrick M., Lillie, M. Layne, Martin, Karen, Martin, Sara C., McDavid, Georgia E., McKee, Shannon, Pierce Tate, Patti L., Rodgers, Shawna, Siddiki, Saba Khan, Sperry, Daniel K., Wright, Sharon L., Sánchez, Pablo J., Nelin, Leif D., Jadcherla, Sudarshan R., Luzader, Patricia, Fortney, Christine A., Grothause, Jennifer L., Wallace, Dennis, Gantz, Marie G., Zaterka-Baxter, Kristin M., Crawford, Margaret M., McDonald, Scott A., Newman, Jamie E., O'Donnell Auman, Jeanette, Petrie Huitema, Carolyn M., Pickett, James W., II, Yost, Patricia, Van Meurs, Krisa P., Stevenson, David K., Ball, M. Bethany, Bentley, Barbara, Chock, Valerie Y., Bruno, Elizabeth F., Davis, Alexis S., DeAnda, Maria Elena, DeBattista, Anne M., Earhart, Beth, Huffman, Lynne C., Kohn, Jean G., Krueger, Casey E., Proud, Melinda S., Rhine, William D., St. John, Nicholas H., Taylor, Heather, Weiss, Hali E., Carlo, Waldemar A., Peralta-Carcelen, Myriam, Collins, Monica V., Cosby, Shirley S., Phillips, Vivien A., Rector, Richard V., Whitley, Sally, Colaizy, Tarah T., Brumbaugh, Jane E., Johnson, Karen J., Eastman, Diane L., Acarregui, Michael J., Walker, Jacky R., Goeke, Claire A., Klein, Jonathan M., Krutzfield, Nancy J., Segar, Jeffrey L., Dagle, John M., Lindower, Julie B., McElroy, Steven J., Rabe, Glenda K., Roghair, Robert D., Meyer, Lauritz R., Ellsbury, Dan L., Campbell, Donia B., Murphy, Cary R., Bhavsar, Vipinchandra, Ohls, Robin K., Lacy, Conra Backstrom, Beauman, Sandra Sundquist, Brown, Sandra, Fernandez, Erika, Duncan, Andrea Freeman, Fuller, Janell, Kuan, Elizabeth, Lowe, Jean R., Schmidt, Barbara, Kirpalani, Haresh, DeMauro, Sara B., Dysart, Kevin C., Abbasi, Soraya, Mancini, Toni, Cucinotta, Dara M., Bernbaum, Judy C., Gerdes, Marsha, Hurt, Hallam, D'Angio, Carl, Lakshminrusimha, Satyan, Laroia, Nirupama, Myers, Gary J., Yost, Kelley, Guilford, Stephanie, Jensen, Rosemary L., Wynn, Karen, Farooq, Osman, Reynolds, Anne Marie, Wadkins, Holly I.M., Williams, Ashley, Merzbach, Joan, Conway, Patrick, Bowman, Melissa, Hartley-McAndrew, Michele, Zorn, William, Fallone, Cait, Binion, Kyle, Orme, Constance, Scorsone, Ann Marie, Brion, Luc P., Chalak, Lina F., Heyne, Roy J., Chen, Lijun, Vasil, Diana M., Adams, Sally S., Boatman, Catherine Twell, Guzman, Alicia, Heyne, Elizabeth T., Lee, Lizette E., Leps, Melissa H., Madden, Linda A., Miller, Nancy A., Ramon, Emma, Yoder, Bradley A., Osborne, Karen A., Spencer, Cynthia, Steele, R. Edison, Steffen, Mike, Strong, Karena, Weaver-Lewis, Kimberlee, Baker, Shawna, Winter, Sarah, Bird, Karie, Burnett, Jill, Sood, Beena G., Bara, Rebecca, Childs, Kirsten, De Jesus, Lilia C., Panaitescu, Bogdan, Chawla, Sanjay M.D., Prentice, Jeannette E., Goldston, Laura A., Woldt, Eunice Hinz, Natarajan, Girija, Bajaj, Monika, Barks, John, Christensen, Mary, Wiggins, Stephanie A., Laptook, Abbot R., Shankaran, Seetha, Barnes, Patrick, Rollins, Nancy, Do, Barbara T., Parikh, Nehal A., Hamrick, Shannon, Hintz, Susan R., Tyson, Jon E., Bell, Edward F., Ambalavanan, Namasivayam, Goldberg, Ronald N., Pappas, Athina, Huitema, Carolyn, Pedroza, Claudia, Chaudhary, Aasma S., Hensman, Angelita M., Das, Abhik, Wyckoff, Myra, Khan, Amir, Walsh, Michelle C., Watterberg, Kristi L., Faix, Roger, Truog, William, Guillet, Ronnie, Sokol, Gregory M., and Poindexter, Brenda B.

Published
2021
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28. Characterizing Enoxaparin's Population Pharmacokinetics to Guide Dose Individualization in the Pediatric Population.

Author

Carreño, Fernando O., Gerhart, Jacqueline G., Helfer, Victória E., Sinha, Jaydeep, Kumar, Karan R., Kirkpatrick, Carl, Hornik, Christoph P., Gonzalez, Daniel, the Best Pharmaceuticals for Children Act–Pediatric Trials Network Steering Committee, Benjamin Jr., Daniel K., Zimmerman, Kanecia, Kennel, Phyllis, Alderman, Cheryl, Sund, Zoe, Opel, Kylie, Beci, Rose, Hornik, Chi Dang, Kearns, Gregory L., Laughon, Matthew, and Paul, Ian M.

Subjects
CHILD patients, ENOXAPARIN, PHARMACOKINETICS, BODY mass index, PERSONAL names, CHILDHOOD obesity, BODY weight
Abstract

Background and Objective: Pediatric dosing of enoxaparin was derived based on extrapolation of the adult therapeutic range to children. However, a large fraction of children do not achieve therapeutic anticoagulation with initial dosing. We aim to use real-world anti-Xa data obtained from children receiving enoxaparin per standard of care to characterize the population pharmacokinetics (PopPK).Author names: Please confirm if the author names are presented accurately and in the correct sequence (given name, middle name/initial, family name). Also, kindly confirm the details in the metadata are correct.The author names are accurately presented and the metadata are correct. Methods: A PopPK analysis was performed using NONMEM, and a stepwise covariate modeling approach was applied for the covariate selection. The final PopPK model, developed with data from 1293 patients ranging in age from 1 day to 18 years, was used to simulate enoxaparin subcutaneous dosing for prophylaxis and treatment based on total body weight (0–18 years, TBW) or fat-free mass (2–18 years, FFM). Simulated exposures in children with obesity (body mass index percentile ≥95th percentile) were compared with those without obesity. Results: A linear, one-compartment PopPK model that included allometric scaling using TBW (<2 years) or FFM (≥2 years) characterized the enoxaparin pharmacokinetic data. In addition, serum creatinine was identified as a significant covariate influencing clearance. Simulations indicated that in patients aged <2 years, the recommended 1.5 mg/kg TBW-based dosing achieves therapeutic simulated concentrations. In pediatric patients aged ≥2 years, the recommended 1.0 mg/kg dose resulted in exposures more comparable in children with and without obesity when FFM weight-based dosing was applied. Conclusion: Using real-world data and PopPK modeling, enoxaparin's pharmacokinetics were characterized in pediatric patients. Using FFM and twice-daily dosing might reduce the risk of overdosing, especially in children with obesity. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Behavior Profiles at 2 Years for Children Born Extremely Preterm with Bronchopulmonary Dysplasia

Author

Caplan, Michael S., Polin, Richard A., Laptook, Abbot R., Keszler, Martin, Hensman, Angelita M., Vieira, Elisa, Little, Emilee, Burke, Robert T., Stephens, Bonnie E., Alksninis, Barbara, Bishop, Carmena, Keszler, Mary L., Leach, Teresa M., Watson, Victoria E., Knoll, Andrea M., Walsh, Michele C., Fanaroff, Avroy A., Newman, Nancy S., Wilson-Costello, Deanne E., Payne, Allison, Bhola, Monika, Yalcinkaya, Gulgun, Siner, Bonnie S., Friedman, Harriet G., Roth, Elizabeth, Truog, William E., Pallotto, Eugenia K., Kilbride, Howard W., Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Knutson, Allison, Schibler, Kurt, Poindexter, Brenda B., Merhar, Stephanie, Yolton, Kimberly, Gratton, Teresa L., Grisby, Cathy, Kirker, Kristin, Wuertz, Sandra, Carlton, David P., Adams-Chapman, Ira, Hale, Ellen C., Loggins, Yvonne C., Bottcher, Diane I., Mackie, Colleen, Carter, Sheena L., LaRossa, Maureen Mulligan, Wineski, Lynn C., Smikle, Gloria V., Leon-Hernandez, Angela, Kendrick-Allwood, Salathiel, Cotten, C. Michael, Goldberg, Ronald N., Goldstein, Ricki F., Malcolm, William F., Ashley, Patricia L., Finkle, Joanne, Fisher, Kimberley A., Grimes, Sandra, Gustafson, Kathryn E., Laughon, Matthew M., Bose, Carl L., Bernhardt, Janice, Bose, Gennie, Warner, Diane, Wereszczak, Janice, Kicklighter, Stephen D., Rhodes-Ryan, Ginger, Higgins, Rosemary D., Wilson Archer, Stephanie, Sokol, Gregory M., Papile, Lu Ann, Hines, Abbey C., Herron, Dianne E., Gunn, Susan, Smiley, Lucy, Kennedy, Kathleen A., Tyson, Jon E., Arldt-McAlister, Julie, Burson, Katrina, Dempsey, Allison G., Evans, Patricia W., Garcia, Carmen, Jiminez, Margarita, John, Janice, Jones, Patrick M., Lillie, M. Layne, Martin, Karen, Martin, Sara C., McDavid, Georgia E., Rodgers, Shawna, Siddiki, Saba Khan, Sperry, Daniel, Pierce Tate, Patti L., Wright, Sharon L., Sánchez, Pablo J., Nelin, Leif D., Jadcherla, Sudarshan R., Luzader, Patricia, Fortney, Christine A., Besner, Gail E., Parikh, Nehal A., Wallace, Dennis, Gantz, Marie G., Newman, Jamie E., Auman, Jeanette O'Donnell, Crawford, Margaret, Gabrio, Jenna, Leblond, David, Petrie Huitema, Carolyn M., Zaterka-Baxter, Kristin M., Van Meurs, Krisa P., Chock, Valerie Y., Stevenson, David K., Adams, Marian M., Ball, M. Bethany, Bentley, Barbara, DeAnda, Maria Elena, Debattista, Anne M., Earhart, Beth, Huffman, Lynne C., Ismael, Magdy, Krueger, Casey E., Palmquist, Andrew W., Proud, Melinda S., Reichert, Elizabeth N., Sankar, Meera N., St. John, Nicholas H., Taylor, Heather L., Weiss, Hali E., Frantz, Ivan D., III, Fiascone, John M., MacKinnon, Brenda L., Nylen, Ellen, Furey, Anne, Sibley, Cecelia E., Brussa, Ana K., Carlo, Waldemar A., Ambalavanan, Namasivayam, Bailey, Kirstin J., Biasini, Fred J., Collins, Monica V., Cosby, Shirley S., Phillips, Vivien A., Rector, Richard V., Whitley, Sally, Devaskar, Uday, Garg, Meena, Purdy, Isabell B., Chanlaw, Teresa, Geller, Rachel, Finer, Neil N., Vaucher, Yvonne E., Kaegi, David, Rasmussen, Maynard R., Arnell, Kathy, Demetrio, Clarence, Fuller, Martha G., Rich, Wade, West, Radmila, Baack, Michelle L., Ellsbury, Dan L., Hogden, Laurie A., Klein, Jonathan M., Dagle, John M., Johnson, Karen J., Tud, Tracy L., Elenkiwich, Chelsey, Henning, Megan M., Broadbent, Megan, Schmelzel, Mendi L., Walker, Jacky R., Goeke, Claire A., Watterberg, Kristi L., Ohls, Robin K., Backstrom Lacy, Conra, Brown, Sandra, Fuller, Janell, Hartenberger, Carol, Lowe, Jean R., Sundquist Beauman, Sandra, Hanson, Mary Ruffner, Dupont, Tara, Kuan, Elizabeth, Schmidt, Barbara, Kirpalani, Haresh, Chaudhary, Aasma S., Abbasi, Soraya, Mancini, Toni, Cucinotta, Dara M., Bernbaum, Judy C., Gerdes, Marsha, Hurt, Hallam, D'Angio, Carl T., Guillet, Ronnie, Myers, Gary J., Lakshminrusimha, Satyan, Reynolds, Anne Marie, Hartley-McAndrew, Michelle E., Wadkins, Holly I.M., Sacilowski, Michael G., Reubens, Linda J., Jensen, Rosemary L., Merzbach, Joan, Zorn, William, Farooq, Osman, Maffett, Deanna, Williams, Ashley, Hunn, Julianne, Guilford, Stephanie, Yost, Kelley, Rowan, Mary, Prinzing, Diane M., Wynn, Karen, Fallone, Cait, Scorsone, Ann Marie, Wyckoff, Myra H., Brion, Luc P., Heyne, Roy J., Vasil, Diana M., Adams, Sally S., Chen, Lijun, De Leon, Maria M., Eubanks, Frances, Guzman, Alicia, Heyne, Elizabeth T., Madden, Linda A., Miller, Nancy A., Lee, Lizette E., Pavageau, Lara, Sepulveda, Pollieanna, Boatman, Cathy Twell, Faix, Roger G., Yoder, Bradley A., Baserga, Mariana, Osborne, Karen A., Baker, Shawna, Bird, Karie, Burnett, Jill, Christensen, Susan, Davis, Brandy, Elmont, Jennifer O., Jensen, Jennifer J., Loertscher, Manndi C., Marchant, Trisha, Maxson, Earl, Minton, Stephen D., Parry, D. Melody, Rau, Carrie A., Schaefer, Susan T., Sheffield, Mark J., Spencer, Cynthia, Steffen, Mike, Weaver-Lewis, Kimberlee, Winter, Sarah, Woodbury, Kathryn D., Zanetti, Karen, Shankaran, Seetha, Chawla, Sanjay, Sood, Beena G., Pappas, Athina, Natarajan, Girija, Bajaj, Monika, Bara, Rebecca, Johnson, Mary E., Goldston, Laura, Wiggins, Stephanie A., Christensen, Mary K., Carlson, Martha, Barks, John, White, Diane F., Ehrenkranz, Richard A., Jacobs, Harris, Butler, Christine G., Cervone, Patricia, Greisman, Sheila, Konstantino, Monica, Poulsen, JoAnn, Taft, Janet, Romano, Elaine, Brumbaugh, Jane E., Bell, Edward F., Grey, Scott F., DeMauro, Sara B., Vohr, Betty R., Harmon, Heidi M., Bann, Carla M., Rysavy, Matthew A., Logan, J. Wells, Colaizy, Tarah T., Peralta-Carcelen, Myriam A., McGowan, Elisabeth C., Duncan, Andrea F., Stoll, Barbara J., Das, Abhik, and Hintz, Susan R.

Published
2020
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34. Developmental Outcomes of Extremely Preterm Infants with a Need for Child Protective Services Supervision

Author

Polin, Richard A., Laptook, Abbott R., Keszler, Martin, Hensman, Angelita M., Alksninis, Barbara, Basso, Kristin M., Burke, Robert, Caskey, Melinda, Johnson, Katharine, Keszler, Mary Lenore, Knoll, Andrea M., Leach, Theresa M., Little, Emilee, McGowan, Elisabeth C., Vieira, Elisa, Watson, Victoria E., Ventura, Suzy, Walsh, Michele C., Fanaroff, Avroy A., Hibbs, Anna Marie, Wilson-Costello, Deanne E., Newman, Nancy S., Payne, Allison H., Siner, Bonnie S., Bhola, Monika, Yalcinkaya, Gulgun, Friedman, Harriet G., Truog, William E., Pallotto, Eugenia K., Kilbride, Howard W., Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Knutson, Allison, Schibler, Kurt, Donovan, Edward F., Grisby, Cathy, Bridges, Kate, Alexander, Barbara, Fischer, Estelle E., Mincey, Holly L., Hessling, Jody, Gratton, Teresa L., Jackson, Lenora, Kirker, Kristin, Muthig, Greg, Steichen, Jean J., Tepe, Stacey, Yolton, Kimberly, Goldberg, Ronald N., Cotten, C. Michael, Goldstein, Ricki F., Ashley, Patricia L., Malcolm, William F., Auten, Kathy J., Fisher, Kimberley A., Grimes, Sandra, Gustafson, Kathryn E., Lohmeyer, Melody B., Finkle, Joanne, Laughon, Matthew M., Bose, Carl L., Bernhardt, Janice, Bose, Gennie, Clark, Cindy, Manor, Linda, Warner, Diane, Wereszczak, Janice, Carlton, David P., Stoll, Barbara J., Adams-Chapman, Ira, Hale, Ellen C., Loggins, Yvonne, Archer, Stephanie Wilson, Sokol, Gregory M., Poindexter, Brenda B., Dusick, Anna M., Papile, Lu-Ann, Gunn, Susan, Hamer, Faithe, Herron, Dianne E., Hines, Abbey C., Lytle, Carolyn, Minnich, Heike M., Smiley, Lucy, Wilson, Leslie Dawn, Sanchez, Pablo J., Nelin, Leif D., Jadcherla, Sudarshan R., Luzader, Patricia, Fortney, Christine A., Besner, Gail E., Parikh, Nehal A., Das, Abhik, Wallace, Dennis, Gantz, Marie G., Poole, W. Kenneth, Newman, Jamie E., O'Donnell Auman, Jeanette, Crawford, Margaret M., Petrie Huitema, Carolyn M., Zaterka-Baxter, Kristin M., Van Meurs, Krisa P., Stevenson, David K., Hintz, Susan R., Ball, M. Bethany, Davis, Alexis S., Palmquist, Andrew W., Proud, Melinda S., Bentley, Barbara, Bruno, Elizabeth, DeAnda, Maria Elena, DeBattista, Anne M., Earhart, Beth, Huffman, Lynne C., Kohn, Jean G., Krueger, Casey, Weiss, Hali E., Frantz, Ivan D., III, Fiascone, John M., MacKinnon, Brenda L., Furey, Anne, Nylen, Ellen, Carlo, Waldemar A., Ambalavanan, Namasivayam, Peralta-Carcelen, Myriam, Collins, Monica V., Cosby, Shirley S., Biasini, Fred J., Johnston, Kristen C., Nelson, Kathleen G., Patterson, Cryshelle S., Phillips, Vivien A., Whitley, Sally, Devaskar, Uday, Garg, Meena, Purdy, Isabell B., Chanlaw, Teresa, Geller, Rachel, Finer, Neil N., Vaucher, Yvonne E., Kaegi, David, Rasmussen, Maynard R., Arnell, Kathy, Demetrio, Clarence, Fuller, Martha G., Rich, Wade, Bell, Edward F., Colaizy, Tarah T., Acarregui, Michael J., Ellsbury, Dan L., Widness, John A., Johnson, Karen J., Campbell, Donia B., Eastman, Diane L., Walker, Jacky R., Brumbaugh, Jane E., Duara, Shahnaz, Bauer, Charles R., Everett-Thomas, Ruth, Fajardo-Hiriart, Sylvia, Rigaud, Arielle, Calejo, Maria, Frade Eguaras, Silvia M., Berkowits, Michelle Harwood, Garcia, Andrea, Pierre, Helina, Stoerger, Alexandra, Watterberg, Kristi L., Lowe, Jean R., Fuller, Janell F., Ohls, Robin K., Lacy, Conra Backstrom, Duncan, Andrea F., Montman, Rebecca, Schmidt, Barbara, Kirpalani, Haresh, DeMauro, Sara B., Chaudhary, Aasma S., Abbasi, Soraya, Mancini, Toni, Cucinotta, Dara M., Bernbaum, Judy C., Gerdes, Marsha, Hurt, Hallam, D'Angio, Carl T., Phelps, Dale L., Guillet, Ronnie, Lakshminrusimha, Satyan, Johnson, Julie Babish, Reubens, Linda J., Horihan, Cassandra A., Hust, Diane, Jensen, Rosemary L., Kushner, Emily, Merzbach, Joan, Myers, Gary J., Rowan, Mary, Wadkins, Holly I.M., Bowman, Melissa, Hunn, Julianne, Guilford, Stephanie, Maffett, Deanna, Osman, Farooq, Prinzing, Diane, Reynolds, Anne Marie, Sacilowski, Michael G., Williams, Ashley, Wynn, Karen, Yost, Kelley, Zorn, William, Zwetsch, Lauren, Kennedy, Kathleen A., Tyson, Jon E., McDavid, Georgia E., Alaniz, Nora I., Arldt-McAlister, Julie, Burson, Katrina, Evans, Patricia W., Garcia, Carmen, Green, Charles, Harris, Beverly Foley, Jiminez, Margarita, John, Janice, Jones, Patrick M., Lillie, Layne M., Lis, Anna E., Martin, Karen, Martin, Sara C., Morris, Brenda H., Poundstone, M. Layne, Robichaux, Peggy, Rodgers, Shawna, Siddiki, Saba, Simmons, Maegan C., Sperry, Daniel, Pierce Tate, Patti L., Wright, Sharon L., Wyckoff, Myra H., Brion, Luc P., Heyne, Roy J., Salhab, Walid A., Rosenfeld, Charles R., Vasil, Diana M., Chen, Lijun, Guzman, Alicia, Hensley, Gaynelle, Leps, Melissa H., Miller, Nancy A., Morgan, Janet S., Adams, Sally S., Boatman, Catherine Twell, Heyne, Elizabeth T., Madden, Linda A., Torres, Lizette E., Faix, Roger G., Yoder, Bradley A., Osborne, Karen A., Spencer, Cynthia, Weaver-Lewis, Kimberlee, Baker, Shawna, Bird, Karie, Burnett, Jill, Steffen, Michael, Jensen, Jennifer J., Winter, Sarah, Zanetti, Karen, O'Shea, T. Michael, Dillard, Robert G., Washburn, Lisa K., Jackson, Barbara G., Peters, Nancy, Chiu, Korinne, Allred, Deborah Evans, Goldstein, Donald J., Halfond, Raquel, Peterson, Carroll, Waldrep, Ellen L., Welch, Cherrie D., Morris, Melissa Whalen, Hounshell, Gail Wiley, Shankaran, Seetha, Pappas, Athina, Barks, John, Bara, Rebecca, Goldston, Laura A., Natarajan, Girija, Christensen, Mary, Wiggins, Stephanie A., White, Diane, Ehrenkranz, Richard A., Jacobs, Harris, Butler, Christine G., Cervone, Patricia, Greisman, Sheila, Konstantino, Monica, Poulsen, JoAnn, Taft, Janet, Williams, Joanne, Romano, Elaine, Laptook, Abbot. R., Lowe, Jean, Chowdhury, Dhuly, Higgins, Rosemary D., and Vohr, Betty R.

Published
2019
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39. Weaning of Moderately Preterm Infants from the Incubator to the Crib: A Randomized Clinical Trial

Author

Polin, Richard A., Keszler, Martin, Hensman, Angelita M., Vieira, Elisa, Hibbs, Anna Marie, Siner, Bonnie S., Truog, William E., Pallotto, Eugenia K., Kilbride, Howard W., Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Schibler, Kurt, Kallapur, Suhas G., Grisby, Cathy, Alexander, Barbara, Fischer, Estelle E., Jackson, Lenora, Kirker, Kristin, Jennings, Jennifer, Wuertz, Sandra, Muthig, Greg, Cotten, C. Michael, Goldberg, Ronald N., Roach, Theresa, Finkle, Joanne, Fisher, Kimberley A., Laughon, Matthew M., Bose, Carl L., Bernhardt, Janice, Clark, Cindy, Kicklighter, Stephen D., Rhodes-Ryan, Ginger, Hale, Ellen C., Loggins, Yvonne, Bottcher, Diane I., Archer, Stephanie Wilson, Harmon, Heidi, Herron, Dianne E., Wright-Coltart, Shirley I., Nelin, Leif D., Jadcherla, Sudarshan R., Luzader, Patricia, Gutentag, Julie, Park, Courtney, Shadd, Julie C., Sullivan, Margaret, Grothause, Jennifer L., Stein, Melanie, Clark, Erna, Sullivan, Rox Ann, Wallace, Dennis, Zaterka-Baxter, Kristin M., Crawford, Margaret, Auman, Jeanette O'Donnell, Stevenson, David K., Herfert, Lou Ann, Ball, M. Bethany, Goodlin, Gabrielle T., Proud, Melinda S., Williams, R. Jordan, Ambalavanan, Namasivayam, Collins, Monica V., Cosby, Shirley S., Chanlaw, Teresa, Geller, Rachel, Ellsbury, Dan L., Brumbaugh, Jane E., Johnson, Karen J., Campbell, Donia B., Walker, Jacky R., Watterberg, Kristi, Lacy, Conra Backstrom, Beauman, Sandy Sundquist, Hartenberger, Carol, Kirpalani, Haresh, Eichenwald, Eric C., DeMauro, Sara B., Cook, Noah, Chaudhary, Aasma S., Abbasi, Soraya, Mancini, Toni, Cucinotta, Dara, Lakshminrusimha, Satyan, Guillet, Ronnie, Scorsone, Ann Marie, Hunn, Julianne, Jensen, Rosemary, Wadkins, Holly I.M., Guilford, Stephanie, Williams, Ashley, Wyckoff, Myra, Brion, Luc P., Vasil, Diana M., Chen, Lijun, Torres, Lizette E., Pappas, Athina, Panaitescu, Bogdan, Handel, Shelley, White, Diane F., Christensen, Mary, Wiggins, Stephanie A., Shankaran, Seetha, Bell, Edward F., Laptook, Abbot R., Saha, Shampa, Newman, Nancy S., Kazzi, S. Nadya J., Barks, John, Stoll, Barbara J., Bara, Rebecca, Gabrio, Jenna, Childs, Kirsten, Das, Abhik, Higgins, Rosemary D., Carlo, Waldemar A., Sánchez, Pablo J., Carlton, David P., Pavageau, Lara, Malcolm, William F., D'Angio, Carl T., Ohls, Robin K., Poindexter, Brenda B., Sokol, Gregory M., Van Meurs, Krisa P., Colaizy, Tarah T., Khmour, Ayman, Puopolo, Karen M., Garg, Meena, and Walsh, Michele C.

Published
2019
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40. Respiratory Outcomes of Infants Born Extremely Preterm in the Necrotizing Enterocolitis Surgery Trial

Author

Laptook, Abbot R., Keszler, Martin, Vohr, Betty R., Kurkchubasche, Arlette, Hensman, Angelita M., Vieira, Elisa, St. Pierre, Lucille, Alksninis, Barbara, Knoll, Andrea, Keszler, Mary L., Leach, Teresa M., McGowan, Elisabeth C., Watson, Victoria E., Maria Hibbs, Anna, Walsh, Michele C., Newman, Nancy S., Wilson-Costello, Deanne E., Siner, Bonnie S., Roth, Elizabeth, Truog, William E., Pallotto, Eugenia K., Kilbride, Howard W., Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Scott, Allison, Parimi, Prabhu S., Gaetano, Lisa, Merhar, Stephanie, Poindexter, Brenda B., Schibler, Kurt, Cahill, Tanya E., Russell, David, Gratton, Tari, Jackson, Lenora, Thompson, Julia, Beiersdorfer, Traci, Grisby, Cathy, Kirker, Kristin, Wuertz, Sandra, Dudley, Juanita, Henkes, Lisa, Stacey, Sara, Hayes, Devan, Cotten, C. Michael, Laughon, Matthew M., Goldberg, Ronald N., Malcolm, William F., Ashley, Patricia L., Mago-Shah, Deesha, Warren, Mollie, Finkle, Joanne, Fisher, Kimberley A., Gustafson, Kathryn E., Bose, Carl L., Bernhardt, Janice, Bose, Gennie, Wereszczak, Janice, Trembath, Andrea, Talbert, Jennifer, Kicklighter, Stephen D., Moore, Ryan, Bentley, Alexandra, Edwards, Laura, Rhodes-Ryan, Ginger, White, Donna, Patel, Ravi M., Carlton, David P., Stoll, Barbara J., Maitre, Nathalie L., Adams-Chapman, Ira, Loggins, Yvonne, Hale, Ellen C., Bottcher, Diane, Carter, Sheena L., Kendrick-Allwood, Salathiel, LaRossa, Maureen Mulligan, Laursen, Judith, Mackie, Colleen, Sanders, Amy, Smikle, Gloria, Wineski, Lynn, Bremer, Andrew A., Archer, Stephanie Wilson, Sokol, Gregory M., Dusick, Anna, Papile, Lu Ann, Harmon, Heidi M., Hines, Abbey C., Herron, Dianne E., Lytle, Carolyn, Smiley, Lucy, Dawn Wilson, Leslie, Watkins, Donna, Gunn, Susan, Joyce, Jeff, Khan, Amir M., Kennedy, Kathleen A., Duncan, Andrea F., Eason, Elizabeth, Evans, Patricia, Jones, Patrick, Mosquera, Ricardo A., Lally, Kevin, Stoll, Barbara, Alaniz, Nora, Allain, Elizabeth, Arldt-McAlister, Julie, Boricha, Fatima, Burson, Katrina, Boral, Debasree Sana, Dempsey, IMG; Allison G., Garcia, Carmen, Green, Charles, Hall, Donna J., Jimenez, Margarita, John, Janice, Lillie, M. Layne, Mason, Carrie, Martin, Karen, Martin, Sarah, McDavid, Georgia E., McKee, Shannon L., Rennie, Kimberly, Reddy, Tina, Rodgers, Shawna, Siddiki, Saba, Sperry, Daniel K., Stephens, Emily, Tate, Patti L., Wright, Sharon L., Nelin, Leif D., Slaughter, Jonathan L., Jadcherla, Sudarshan R., Timan, Christopher, Fathi, Omid, Yeates, Keith O., Luzader, Patricia, Gutentag, Julie, Grothause, Jennifer L., Stein, Melanie, Sullivan, Rox Ann, Hague, Cole D., Carey, Helen, Chao, Michelle, Burkhardt, Stephanie, Sullivan, Margaret, Yossef-Salameh, Lina, Nelin, Mary Ann, Clark, Erna, Shadd, Julie C., Park, Courtney, Cira, Courtney, Fearns, Erin, Small, Kristi, Keim, Sarah A., Fortney, Christine A., Fowler, Aubrey, McCool, Jacqueline, Pietruszewski, Lindsay, Purnell, Jessica, Warnimont, CCRC; Kyrstin, Marzec, Laura, Miller, Bethany, Beckford, Demi R., Baugher, Hallie, Newton, Julia, Levengood, Katelyn, Batterson, Nancy, Brittany DeSantis, Das, Abhik, Bann, Carla M., Wallace, Dennis, Gantz, Marie G., O’Donnell Auman, Jeanette, Crawford, Margaret, Gabrio, Jenna, Newman, Jamie E., Parlberg, Lindsay, Petrie Huitema, Carolyn M., Zaterka-Baxter, Kristin M., Lewis, Amanda, Van Meurs, Krisa P., Ball, M. Bethany, Chock, Valerie Y., Adams, Marian M., Davis, Alexis S., Bentley, Barbara, DeAnda, Maria Elena, DeBattista, Anne M., Earhart, Beth, Huffman, Lynne C., Krueger, Casey E., Lucash, Ryan E., Proud, Melinda S., Reichert, Elizabeth N., Taylor, CCRC; Heather, Weiss, Hali E., Williams, R. Jordan, Frantz, Ivan D., III, Fiascone, John M., MacKinnon, Brenda L., Furey, Anne, Nylen, Ellen, Church, Paige T., Carlo, Waldemar A., Ambalavanan, Namasivayam, Peralta-Carcelen, Myriam, Bailey, Kirstin J., Biasini, Fred J., Chopko, Stephanie A., Collins, Monica V., Cosby, Shirley S., Domnanovich, Kristy A., Jno-Finn, Chantel J., Ladinsky, Morissa, Moses, Mary Beth, McNair, Tara E., Phillips, Vivien A., Preskitt, Julie, Rector, Richard V., Stringer, Kimberlly, Whitley, Sally, Chapman, Sheree York, Devaskar, Uday, Garg, Meena, Purdy, Isabell B., Chanlaw, Teresa, Geller, Rachel, Bell, Edward F., Colaizy, Tarah T., Widness, John A., Brumbaugh, Jane E., Johnson, Karen J., Schmelzel, Mendi L., Walker, Jacky R., Goeke, Claire A., Eastman, Diane L., Henning, Megan M., Elenkiwich, Chelsey, Broadbent, Megan, Van Muyden, Sarah, Ellsbury, Dan L., Bass, Donia B., Tud, Tracy L., Pitcher, Graeme J., Shelton, Julia S., Watterberg, Kristi L., Fuller, Janell, Ohls, Robin K., Lacy, Conra Backstrom, Hartenberger, Carol, Brown, Sandra, Beauman, Sandra Sundquist, Lowe, Jean R., Eichenwald, Eric C., Schmidt, Barbara, Kirpalani, Haresh, Abbasi, Soraya, Chaudhary, Aasma S., Mancini, Toni, Cucinotta, Dara M., Bernbaum, Judy C., Gerdes, Marsha, Hurt, Hallam, Snyder, Jonathan, Ziolkowski, Kristina, D’Angio, Carl T., Guillet, Ronnie, Lakshminrusimha, Satyan, Myers, Gary J., Reynolds, Anne Marie, Wadkins, Holly I.M., Sacilowski, Michael G., Jensen, Rosemary L., Merzbach, Joan, Zorn, LMSW; William, Farooq, Osman, Guilford, Stephanie, Yost, Kelley, Scorsone, Ann Marie, Hartley-McAndrew, CCRC; Michelle, Binion, Kyle, Orme, Constance, Sabaratnam, Premini, Kent, Alison, Jones, Rachel, Li, Emily, Kachelmeyer, Jennifer, McKee, Kimberly G., Coleman, Kelly R., Stevens, Timothy, Lee, Yi Horng, Pegoli, Walter, Gitzelman, Christopher, Wakeman, Derek, Horihan, Cassandra, Hunn, Julianne, Bowman, Melissa, Fallone, Cait, Wynn, Karen, Conway, Patrick, Williams, Ashley, Wyckoff, Myra H., Brion, Luc P., Heyne, Roy J., Vasil, Diana M., Adams, Sally S., Chen, Lijun, De Leon, Maria M., Eubanks, Frances, Madden, Linda A., McDougald, E. Rebecca, Lara Pavageau, Sepulveda, Pollieanna, Guzman, Alicia, Heyne, Elizabeth, Lee, Lizette E., Vera, Azucena, Waterbury, Jillian, Boatman, Cathy Twell, Tolentino-Plata, Kristine, Yoder, Bradley A., Baserga, Mariana, Faix, Roger G., Winter, Sarah, Minton, Stephen D., Gerday, Erick B., Rau, Carrie A., Baker, Shawna, Burnett, Jill, Christensen, Susan, Cunningham, Sean D., Elmont, Jennifer O., Hall, Becky, Loertscher, Manndi C., Maxson, Earl, McGrath, Kandace M., Mickelsen, Hena G., Morshedzadeh, Galina, Schaefer, Susan T., Stout, Kelly, Stuart, Ashley L., Weaver-Lewis, Kimberlee, Woodbury, Kathryn D., Shankaran, Seetha, Sood, Beena G., Pappas, Athina, Natarajan, Girija, Chawla, Sanjay, Bajaj, Monika, Agarwal, Prashant, Prentice, Jeanette, February, Melissa, De Jesus, Lilia, Muran, Gerry, Bara, Rebecca, Childs, Kirsten, Panaitescu, Bogdan, Woldt, Eunice, Johnson, Mary E., Goldston, Laura A., Wiggins, Stephanie A., Christensen, Mary K., White, Diane F., Carlson, Martha, Barks, John, Ehrenkranz, Richard A., Jacobs, Harris, Butler, Christine G., Cervone, Patricia, Greisman, Sheila, Konstantino, Monica, Poulsen, JoAnn, Taft, Janet, Williams, Joanne, Romano, Elaine, DeMauro, Sara B., Jensen, Erik A., McDonald, Scott A., Hintz, Susan, Tyson, Jon, Stevenson, David K., and Blakely, Martin L.

Published
2025
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41. Effect of Depth and Duration of Cooling on Deaths in the NICU Among Neonates With Hypoxic Ischemic Encephalopathy: A Randomized Clinical Trial

Author

Shankaran, Seetha, Laptook, Abbot R, Pappas, Athina, McDonald, Scott A, Das, Abhik, Tyson, Jon E, Poindexter, Brenda B, Schibler, Kurt, Bell, Edward F, Heyne, Roy J, Pedroza, Claudia, Bara, Rebecca, Van Meurs, Krisa P, Grisby, Cathy, Huitema, Carolyn M Petrie, Garg, Meena, Ehrenkranz, Richard A, Shepherd, Edward G, Chalak, Lina F, Hamrick, Shannon EG, Khan, Amir M, Reynolds, Anne Marie, Laughon, Matthew M, Truog, William E, Dysart, Kevin C, Carlo, Waldemar A, Walsh, Michele C, Watterberg, Kristi L, and Higgins, Rosemary D

Subjects
Paediatrics, Biomedical and Clinical Sciences, Clinical Research, Perinatal Period - Conditions Originating in Perinatal Period, Clinical Trials and Supportive Activities, Pediatric, Infant Mortality, Reproductive health and childbirth, Acidosis, Arrhythmias, Cardiac, Developmental Disabilities, Female, Hemorrhage, Humans, Hypothermia, Induced, Hypoxia-Ischemia, Brain, Infant, Infant, Newborn, Intensive Care Units, Neonatal, Male, Survival Analysis, Temperature, Thrombosis, Time Factors, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Abstract

ImportanceHypothermia at 33.5°C for 72 hours for neonatal hypoxic ischemic encephalopathy reduces death or disability to 44% to 55%; longer cooling and deeper cooling are neuroprotective in animal models.ObjectiveTo determine if longer duration cooling (120 hours), deeper cooling (32.0°C), or both are superior to cooling at 33.5°C for 72 hours in neonates who are full-term with moderate or severe hypoxic ischemic encephalopathy.Design, setting, and participantsA randomized, 2 × 2 factorial design clinical trial performed in 18 US centers in the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neonatal Research Network between October 2010 and November 2013.InterventionsNeonates were assigned to 4 hypothermia groups; 33.5°C for 72 hours, 32.0°C for 72 hours, 33.5°C for 120 hours, and 32.0°C for 120 hours.Main outcomes and measuresThe primary outcome of death or disability at 18 to 22 months is ongoing. The independent data and safety monitoring committee paused the trial to evaluate safety (cardiac arrhythmia, persistent acidosis, major vessel thrombosis and bleeding, and death in the neonatal intensive care unit [NICU]) after the first 50 neonates were enrolled, then after every subsequent 25 neonates. The trial was closed for emerging safety profile and futility analysis after the eighth review with 364 neonates enrolled (of 726 planned). This report focuses on safety and NICU deaths by marginal comparisons of 72 hours' vs 120 hours' duration and 33.5°C depth vs 32.0°C depth (predefined secondary outcomes).ResultsThe NICU death rates were 7 of 95 neonates (7%) for the 33.5°C for 72 hours group, 13 of 90 neonates (14%) for the 32.0°C for 72 hours group, 15 of 96 neonates (16%) for the 33.5°C for 120 hours group, and 14 of 83 neonates (17%) for the 32.0°C for 120 hours group. The adjusted risk ratio (RR) for NICU deaths for the 120 hours group vs 72 hours group was 1.37 (95% CI, 0.92-2.04) and for the 32.0°C group vs 33.5°C group was 1.24 (95% CI, 0.69-2.25). Safety outcomes were similar between the 120 hours group vs 72 hours group and the 32.0°C group vs 33.5°C group, except major bleeding occurred among 1% in the 120 hours group vs 3% in the 72 hours group (RR, 0.25 [95% CI, 0.07-0.91]). Futility analysis determined that the probability of detecting a statistically significant benefit for longer cooling, deeper cooling, or both for NICU death was less than 2%.Conclusions and relevanceAmong neonates who were full-term with moderate or severe hypoxic ischemic encephalopathy, longer cooling, deeper cooling, or both compared with hypothermia at 33.5°C for 72 hours did not reduce NICU death. These results have implications for patient care and design of future trials.Trial registrationclinicaltrials.gov Identifier: NCT01192776.

Published
2014

42. Patent Ductus Arteriosus in Premature Infants: Clinical Trials and Equipoise

Author

Liguori, Macrina B., primary, Ali, Sanoj K.M., additional, Bussman, Neidín, additional, Colaizy, Tarah, additional, Hundscheid, Tim, additional, Phad, Nilkant, additional, Clyman, Ronald, additional, de Boode, Willem-Pieter, additional, de Waal, Koert, additional, El-Khuffash, Afif, additional, Gupta, Samir, additional, and Laughon, Matthew, additional

Published
2023
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45. Outcome of Preterm Infants with Transient Cystic Periventricular Leukomalacia on Serial Cranial Imaging Up to Term Equivalent Age

Author

Jobe, Alan H., Caplan, Michael S., Polin, Richard A., Keszler, Martin, Oh, William, Vohr, Betty R., Hensman, Angelita M., Alksninis, Barbara, Basso, Kristin M., Burke, Robert, Caskey, Melinda, Johnson, Katharine, Keszler, Mary Lenore, Knoll, Andrea M., Leach, Theresa M., Little, Emilee, McGowan, Elisabeth C., Vieira, Elisa, Watson, Victoria E., Ventura, Suzy, Walsh, Michele C., Fanaroff, Avroy A., Hibbs, Anna Marie, Wilson-Costello, Deanne E., Newman, Nancy S., Payne, Allison H., Siner, Bonnie S., Bhola, Monika, Yalcinkaya, Gulgun, Friedman, Harriet G., Truog, William E., Pallotto, Eugenia K., Kilbride, Howard W., Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Knutson, Allison, Schibler, Kurt, Donovan, Edward F., Grisby, Cathy, Bridges, Kate, Alexander, Barbara, Fischer, Estelle E., Mincey, Holly L., Hessling, Jody, Gratton, Teresa L., Jackson, Lenora, Kirker, Kristin, Muthig, Greg, Steichen, Jean J., Tepe, Stacey, Mersmann, Marcia Worley, Yolton, Kimberly, Goldberg, Ronald N., Cotten, C. Michael, Goldstein, Ricki F., Ashley, Patricia L., Malcolm, William F., Auten, Kathy J., Fisher, Kimberley A., Grimes, Sandra, Gustafson, Kathryn E., Lohmeyer, Melody B., Finkle, Joanne, Laughon, Matthew M., Bose, Carl L., Bernhardt, Janice, Bose, Gennie, Warner, Diane, Wereszczak, Janice, Carlton, David P., Adams-Chapman, Ira, Hale, Ellen C., Loggins, Yvonne, Blackwelder, Ann M., Bottcher, Diane I., Mackie, Colleen, Higgins, Rosemary D., Archer, Stephanie Wilson, Sokol, Gregory M., Poindexter, Brenda B., Lemons, James A., Dusick, Anna M., Papile, Lu-Ann, Lytle, Carolyn, Hines, Abbey C., Minnich, Heike M., Herron, Dianne E., Smiley, Lucy, Gunn, Susan, Wilson, Leslie Dawn, Kennedy, Kathleen A., Tyson, Jon E., McDavid, Georgia E., Akpa, Esther G., Arldt-McAlister, Julie, Alaniz, Nora I., Burson, Katrina, Bradt, Pamela J., Dieterich, Susan, Dempsey, Allison, Duncan, Andrea F., Evans, Patricia W., Franco, Claudia I., Garcia, Carmen, Green, Charles, Harris, Beverly Foley, Jiminez, Margarita, John, Janice, Jones, Patrick M., Lillie, Layne M., Lis, Anna E., Major-Kincade, Terri, Martin, Karen, Martin, Sara C., Morris, Brenda H., Orekoya, Patricia Ann, Reddoch, Stacey, Rodgers, Shawna, Siddiki, Saba, Simmons, Maegan C., Sperry, Daniel, Tate, Patti L. Pierce, Whitely, Laura L., Wright, Sharon L., Nelin, Leif D., Jadcherla, Sudarshan R., Luzader, Patricia, Fortney, Christine A., Besner, Gail E., Parikh, Nehal A., Wallace, Dennis, Gantz, Marie G., Poole, W. Kenneth, Crawford, Margaret M., Gabrio, Jenna, Hastings, Betty K., Newman, Jamie E., O'Donnell Auman, Jeanette, Huitema, Carolyn M. Petrie, Zaterka-Baxter, Kristin M., Stevenson, David K., Ball, M. Bethany, Adams, Marian M., Davis, Alexis S., Palmquist, Andrew W., Proud, Melinda S., Bentley, Barbara, Bruno, Elizabeth, DeAnda, Maria Elena, DeBattista, Anne M., Earhart, Beth, Huffman, Lynne C., Kohn, Jean G., Krueger, Casey, Weiss, Hali E., Frantz, Ivan D., III, Fiascone, John M., MacKinnon, Brenda L., Furey, Anne, Nylen, Ellen, Peralta-Carcelen, Myriam, Collins, Monica V., Cosby, Shirley S., Biasini, Fred J., Johnston, Kristen C., Nelson, Kathleen G., Patterson, Cryshelle S., Phillips, Vivien A., Whitley, Sally, Devaskar, Uday, Garg, Meena, Purdy, Isabell B., Chanlaw, Teresa, Geller, Rachel, Finer, Neil N., Kaegi, David, Rasmussen, Maynard R., Wozniak, Paul R., Arnell, Kathy, Demetrio, Clarence, Fuller, Martha G., Henderson, Chris, Rich, Wade, Vaucher, Yvonne E., Colaizy, Tarah T., Acarregui, Michael J., Brumbaugh, Jane E., Ellsbury, Dan L., Widness, John A., Johnson, Karen J., Campbell, Donia B., Eastman, Diane L., Krutzfield, Nancy J., Duara, Shahnaz, Bauer, Charles R., Everett-Thomas, Ruth, Fajardo-Hiriart, Sylvia, Rigaud, Arielle, Calejo, Maria, Eguaras, Silvia M. Frade, Berkowits, Michelle Harwood, Garcia, Andrea, Pierre, Helina, Stoerger, Alexandra, Watterberg, Kristi L., Lowe, Jean R., Dupont, Tara, Fuller, Janell F., Ohls, Robin K., Lacy, Conra Backstrom, Montman, Rebecca, Schmidt, Barbara, Kirpalani, Haresh, DeMauro, Sara B., Chaudhary, Aasma S., Abbasi, Soraya, Mancini, Toni, Cucinotta, Dara M., Bernbaum, Judy C., Gerdes, Marsha, Hurt, Hallam, Cook, Noah, D'Angio, Carl T., Phelps, Dale L., Guillet, Ronnie, Lakshminrusimha, Satyan, Johnson, Julie Babish, Burnell, Erica, Reubens, Linda J., Horihan, Cassandra A., Jensen, Rosemary L., Kushner, Emily, Merzbach, Joan, Myers, Gary J., Rowan, Mary, Wadkins, Holly I.M., Scorsone, Anne Marie, Bowman, Melissa, Hunn, Julianne, Guilford, Stephanie, Maffett, Deanna, Farooq, Osman, Prinzing, Diane, Reynolds, Anne Marie, Sacilowski, Michael G., Williams, Ashley, Wynn, Karen, Yost, Kelley, Zorn, William, Zwetsch, Lauren, Brion, Luc P., Broyles, R. Sue, Heyne, Roy J., Ipson, Merle, Salhab, Walid A., Rosenfeld, Charles R., Vasil, Diana M., Chen, Lijun, Guzman, Alicia, Hensley, Gaynelle, Hickman, Jackie F., Leps, Melissa H., Madison, Susie, Miller, Nancy A., Morgan, Janet S., Pavageau, Lara, Adams, Sally S., Dooley, Cristin, Heyne, Elizabeth T., Lee, Lizette E., Madden, Linda A., Boatman, Catherine Twell, Faix, Roger G., Yoder, Bradley A., Osborne, Karen A., Spencer, Cynthia, Weaver-Lewis, Kimberlee, Baker, Shawna, Bird, Karie, Burnett, Jill, Steffen, Michael, Jensen, Jennifer J., Winter, Sarah, Zanetti, Karen, O'Shea, T. Michael, Dillard, Robert G., Washburn, Lisa K., Jackson, Barbara G., Peters, Nancy J., Chiu, Korinne, Allred, Deborah Evans, Goldstein, Donald J., Halfond, Raquel, Peterson, Carroll, Waldrep, Ellen L., Welch, Cherrie D., Morris, Melissa Whalen, Hounshell, Gail Wiley, Pappas, Athina, Bara, Rebecca, Goldston, Laura A., Muran, Geraldine, Natarajan, Girija, Christensen, Mary, Wiggins, Stephanie A., White, Diane, Ehrenkranz, Richard A., Jacobs, Harris, Butler, Christine G., Cervone, Patricia, Gettner, Patricia, Greisman, Sheila, Konstantino, Monica, Poulsen, JoAnn, Romano, Elaine, Taft, Janet, Williams, Joanne, Sarkar, Subrata, Shankaran, Seetha, Barks, John, Do, Barbara T., Laptook, Abbot R., Das, Abhik, Ambalavanan, Namasivayam, Van Meurs, Krisa P., Bell, Edward F., Sanchez, Pablo J., Hintz, Susan R., Wyckoff, Myra H., Stoll, Barbara J., and Carlo, Waldemar A.

Published
2018
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46. Delivery Room Resuscitation and Short-Term Outcomes in Moderately Preterm Infants

Author

Polin, Richard A., Keszler, Martin, Hensman, Angelita M., Vieira, Elisa, Hibbs, Anna Marie, Siner, Bonnie S., Truog, William E., Pallotto, Eugenia K., Kilbride, Howard W., Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Poindexter, Brenda B., Schibler, Kurt, Kallapur, Suhas G., Grisby, Cathy, Alexander, Barbara, Fischer, Estelle E., Jackson, Lenora, Kirker, Kristin, Jennings, Jennifer, Wuertz, Sandra, Muthig, Greg, Cotten, C. Michael, Goldberg, Ronald N., Finkle, Joanne, Fisher, Kimberley A., Laughon, Matthew M., Bose, Carl L., Bernhardt, Janice, Clark, Cindy, Carlton, David P., Hale, Ellen C., Loggins, Yvonne, Bottcher, Diane I., Archer, Stephanie Wilson, Sokol, Greg, Herron, Dianne E., Nelin, Leif D., Jadcherla, Sudarshan R., Luzader, Patricia, Parikh, Nehal A., Nist, Marliese Dion, Fuller, Jennifer, Gutentag, Julie, Jones, Marissa E., McGregor, Sarah, Rodgers, Elizabeth, Ulloa, Jodi A., Wolfe, Tara, Wallace, Dennis, Zaterka-Baxter, Kristin M., Crawford, Margaret, Gabrio, Jenna, Kandefer, Sarah, O'Donnell Auman, Jeanette, Stevenson, David K., Ball, M. Bethany, Proud, Melinda S., Ambalavanan, Namasivayam, Collins, Monica V., Cosby, Shirley S., Devaskar, Uday, Garg, Meena, Chanlaw, Teresa, Geller, Rachel, Colaizy, Tarah T., Ellsbury, Dan L., Brumbaugh, Jane E., Johnson, Karen J., Campbell, Donia B., Walker, Jacky R., Watterberg, Kristi L., Ohls, Robin K., Lacy, Conra Backstrom, Beauman, Sandy Sundquist, Hartenberger, Carol, Schmidt, Barbara, Kirpalani, Haresh, DeMauro, Sara B., Cook, Noah, Chaudhary, Aasma S., Abbasi, Soraya, Mancini, Toni, Cucinotta, Dara, Lakshminrusimha, Satyan, Guillet, Ronnie, Scorsone, Ann Marie, Hunn, Julianne, Jensen, Rosemary, Wadkins, Holly I.M., Guilford, Stephanie, Williams, Ashley, Brion, Luc P., Vasil, Diana M., Chen, Lijun, Torres, Lizette E., Kennedy, Kathleen A., Tyson, Jon E., Arldt-McAlister, Julie, Garcia, Carmen, Martin, Karen, McDavid, Georgia E., Wright, Sharon L., Pappas, Athina, Barks, John, Bara, Rebecca, Handel, Shelley, White, Diane F., Christensen, Mary, Wiggins, Stephanie A., Bajaj, Monika, Natarajan, Girija, Shankaran, Seetha, Wyckoff, Myra, Laptook, Abbot R., Bell, Edward F., Stoll, Barbara J., Carlo, Waldemar A., Vohr, Betty R., Saha, Shampa, Van Meurs, Krisa P., Sanchez, Pablo J., D'Angio, Carl T., Higgins, Rosemary D., Das, Abhik, Newman, Nancy, and Walsh, Michele C.

Published
2018
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47. Antecedents and Outcomes of Abnormal Cranial Imaging in Moderately Preterm Infants

Author

Polin, Richard A., Keszler, Martin, Hensman, Angelita M., Vieira, Elisa, Hibbs, Anna Marie, Siner, Bonnie S., Pallotto, Eugenia K., Kilbride, Howard W., Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Kallapur, Suhas G., Grisby, Cathy, Alexander, Barbara, Fischer, Estelle E., Jackson, Lenora, Kirker, Kristin, Jennings, Jennifer, Wuertz, Sandra, Muthig, Greg, Goldberg, Ronald N., Finkle, Joanne, Fisher, Kimberley A., Laughon, Matthew M., Bose, Carl L., Bernhardt, Janice, Clark, Cindy, Carlton, David P., Loggins, Yvonne, Bottcher, Diane I., Archer, Stephanie Wilson, Sokol, Greg, Herron, Dianne E., Nelin, Leif D., Jadcherla, Sudarshan R., Luzader, Patricia, Parikh, Nehal A., Nist, Marliese Dion, Fuller, Jennifer, Gutentag, Julie, Jones, Marissa E., McGregor, Sarah, Rodgers, Elizabeth, Ulloa, Jodi A., Wolfe, Tara, Wallace, Dennis, Zaterka-Baxter, Kristin M., Crawford, Margaret, Gabrio, Jenna, O'Donnell Auman, Jeanette, Stevenson, David K., Ball, M. Bethany, Proud, Melinda S., Ambalavanan, Namasivayam, Collins, Monica V., Cosby, Shirley S., Devaskar, Uday, Garg, Meena, Chanlaw, Teresa, Geller, Rachel, Colaizy, Tarah T., Ellsbury, Dan L., Brumbaugh, Jane E., Johnson, Karen J., Campbell, Donia B., Walker, Jacky R., Ohls, Robin K., Lacy, Conra Backstrom, Beauman, Sandy Sundquist, Hartenberger, Carol, Kirpalani, Haresh, Chaudhary, Aasma S., Abbasi, Soraya, Mancini, Toni, Cucinotta, Dara, Lakshminrusimha, Satyan, Scorsone, Ann Marie, Hunn, Julianne, Jensen, Rosemary, Wadkins, Holly I.M., Guilford, Stephanie, Williams, Ashley, Wyckoff, Myra, Brion, Luc P., Vasil, Diana M., Chen, Lijun, Torres, Lizette E., Tyson, Jon E., Arldt-McAlister, Julie, Garcia, Carmen, Martin, Karen, McDavid, Georgia E., Wright, Sharon L., Pappas, Athina, Barks, John, Bara, Rebecca, Handel, Shelley, White, Diane F., Christensen, Mary, Wiggins, Stephanie A., Natarajan, Girija, Shankaran, Seetha, Saha, Shampa, Laptook, Abbot, Das, Abhik, Higgins, Rosemary, Stoll, Barbara J., Bell, Edward F., Carlo, Waldemar A., D'Angio, Carl, DeMauro, Sara B., Sanchez, Pablo, Van Meurs, Krisa, Vohr, Betty, Newman, Nancy, Hale, Ellen, and Walsh, Michele

Published
2018
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49. Obese Children Require Lower Doses of Pantoprazole Than Nonobese Peers to Achieve Equal Systemic Drug Exposures

Author

Benjamin, Daniel K., Jr, Berezny, Katherine Y., Wolkowiez, P. Michael Cohen, Laughon, Matthew M., Paul, Ian M., Smith, Michael J., van den Anker, John, Wade, Kelly, Siegel, David, Taylor-Zapata, Perdita, Zajicek, Anne, Ren, Zhaoxia, Tsilou, Ekaterini, Pagan, Alice, Anand, Ravinder, Clemons, Traci, Simone, Gina, Howard, Lee, Weigel, Jaylene, Darden Saad, Nancy, Shakhnovich, Valentina, Smith, P. Brian, Guptill, Jeffrey T., James, Laura P., Collier, David N., Wu, Huali, Livingston, Chad E., Zhao, Jian, and Kearns, Gregory L.

Published
2018
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50. Admission Temperature and Associated Mortality and Morbidity among Moderately and Extremely Preterm Infants

Author

Polin, Richard A., Keszler, Martin, Vohr, Betty R., Hensman, Angelita M., Vieira, Elisa, Little, Emilee, Fanaroff, Avroy A., Hibbs, Anna Marie, Newman, Nancy S., Siner, Bonnie S., Truog, William E., Pallotto, Eugenia K., Kilbride, Howard W., Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Schibler, Kurt, Kallapur, Suhas G., Grisby, Cathy, Alexander, Barbara, Fischer, Estelle E., Jackson, Lenora, Kirker, Kristin, Jennings, Jennifer, Wuertz, Sandra, Muthig, Greg, Donovan, Edward F., Hessling, Jody, Mersmann, Marcia Worley, Mincey, Holly L., Cotten, C. Michael, Goldberg, Ronald N., Finkle, Joanne, Fisher, Kimberley A., Auten, Kathy J., Laughon, Matthew M., Bose, Carl L., Bernhardt, Janice, Clark, Cindy, Stoll, Barbara J., Carlton, David P., Hale, Ellen C., Loggins, Yvonne, Bottcher, Diane I., Archer, Stephanie Wilson, Wright, Linda L., McClure, Elizabeth M., Poindexter, Brenda B., Sokol, Gregory M., Herron, Dianne E., Lemons, James A., Appel, Diana D., Miller, Lucy C., Sanchez, Pablo J., Nelin, Leif D., Jadcherla, Sudarshan R., Luzader, Patricia, Parikh, Nehal A., Nist, Marliese Dion, Fuller, Jennifer, Gutentag, Julie, Jones, Marissa E., McGregor, Sarah, Rodgers, Elizabeth, Ulloa, Jodi A., Wolfe, Tara, Das, Abhik, Wallace, Dennis, Poole, W. Kenneth, Zaterka-Baxter, Kristin M., Crawford, Margaret, Gabrio, Jenna, O'Donnell Auman, Jeanette, Huitema, Carolyn Petrie, Hastings, Betty K., Van Meurs, Krisa P., Stevenson, David K., Ball, M. Bethany, Proud, Melinda S., Carlo, Waldemar A., Ambalavanan, Namasivayam, Collins, Monica V., Cosby, Shirley S., Devaskar, Uday, Garg, Meena, Chanlaw, Teresa, Geller, Rachel, Colaizy, Tarah T., Ellsbury, Dan L., Brumbaugh, Jane E., Johnson, Karen J., Campbell, Donia B., Walker, Jacky R., Watterberg, Kristi L., Ohls, Robin K., Lacy, Conra Backstrom, Beauman, Sandra Sundquist, Hartenberger, Carol, Schmidt, Barbara, Kirpalani, Haresh, Cook, Noah, DeMauro, Sara B., Chaudhary, Aasma S., Abbasi, Soraya, Mancini, Toni, Cucinotta, Dara, D'Angio, Carl T., Guillet, Ronnie, Lakshminrusimha, Satyan, Phelps, Dale L., Reynolds, Ann Marie, Hunn, Julianne, Jensen, Rosemary, Wadkins, Holly I.M., Guilford, Stephanie, Williams, Ashley, Sacilowski, Michael, Reubens, Linda, Burnell, Erica, Rowan, Mary, Wynn, Karen, Maffett, Deanna, Brion, Luc P., Vasil, Diana M., Chen, Lijun, Torres, Lizette E., Salhab, Walid A., Madison, Susie, Hensley, Gay, Miller, Nancy A., Guzman, Alicia, Kennedy, Kathleen A., Tyson, Jon E., Arldt-McAlister, Julie, Garcia, Carmen, Martin, Karen, McDavid, Georgia E., Wright, Sharon L., Akpa, Esther G., Cluff, Patty A., Lis, Anna E., Franco, Claudia I., Pappas, Athina, Barks, John, Bara, Rebecca, Handel, Shelley, Muran, Geraldine, White, Diane F., Christensen, Mary, Wiggins, Stephanie A., Laptook, Abbot R., Bell, Edward F., Shankaran, Seetha, Boghossian, Nansi S., Wyckoff, Myra H., Kandefer, Sarah, Walsh, Michele, Saha, Shampa, and Higgins, Rosemary

Published
2018
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