94 results on '"Latteri MA"'
Search Results
2. Survival of patients with hepatocellular carcinoma in cirrhosis: a comparison of BCLC, CLIP and GRETCH staging systems
- Author
-
CAMMA', Calogero, DI MARCO, Vito, CABIBBO, Giuseppe, LATTERI, Federica, SANDONATO, Luigi, PARISI, Pietro, ENEA, Marco, ATTANASIO, Massimo, LICATA, Anna, CRAXI, Antonio, Galia, M, Alessi, N, Latteri, MA, Cammà, C, Di Marco, V, Cabibbo, G, Latteri, F, Sandonato, L, Parisi, P, Enea, M, Attanasio, M, Galia, M, Alessi, N, Licata, A, Latteri, MA, and Craxì A
- Subjects
Hepatocellular carcinoma ,staging systems - Abstract
A major problem in assessing the likelihood of survival of patients with hepatocellular carcinoma (HCC) arises from a lack of models capable of predicting outcome accurately.To compare the ability of the Italian score (CLIP), the French classification (GRETCH) and the Barcelona (BCLC) staging system in predicting survival in patients with HCC.We included 406 consecutive patients with cirrhosis and HCC. Seventy-eight per cent of patients had hepatitis C. Independent predictors of survival were identified using the Cox model.One-hundred and seventy-eight patients were treated, while 228 were untreated. The observed mortality was 60.1% in treated patients and 84.9% in untreated patients. Among treated patients, albumin, bilirubin and performance status were the only independent variables significantly associated with survival. Mortality was independently predicted by bilirubin, alpha-fetoprotein and portal vein thrombosis in untreated patients. CLIP achieved the best discriminative capacity in the entire HCC cohort and in the advanced untreatable cases, while BCLC was the ablest in predicting survival in treated patients.Overall predictive ability of BCLC, CLIP and GRETCH staging systems was not satisfactory, and was not uniform for treated patients and untreated patients. None of the scoring systems provided confident prediction of survival in individual patients.
- Published
- 2008
3. Fine-Needle Aspiration (FNAB) Molecular Analysis for the Diagnosis of Papillary Thyroid Carcinoma through BRAFv600E mutation and RET/PTC rearrangement
- Author
-
PIZZOLANTI, Giuseppe, RUSSO, L, RICHIUSA, P, BRONTE, Vincenzo, NUARA, RB, RODOLICO, VITO, AMATO, Marco Calogero, SMERALDI, Lucia, SISTO, Pasqua Sandra, LATTERI, Mario, NUCERA, Miriam, BOMMARITO, Alessandra, CITARRELLA, Roberto, LO COCO, R, CABIBI, Daniela, LO COCO, A, F. FRASCA, GULOTTA, Gaspare, LATTERI, MA, MODICA, G, GALLUZZO, Aldo, GIORDANO, Carla, PIZZOLANTI, G, RUSSO, L, RICHIUSA, P, BRONTE, V, NUARA, RB, RODOLICO, V, AMATO, MC, SMERALDI, L, SISTO, PS, Latteri, M, NUCERA, M, BOMMARITO, A, CITARRELLA, R, LO COCO, R, CABIBI, D, LO COCO, A, F FRASCA, GULOTTA, G, LATTERI, MA, MODICA, G, GALLUZZO, A, and GIORDANO, C
- Subjects
Adult ,Male ,Proto-Oncogene Proteins B-raf ,Pathology ,medicine.medical_specialty ,endocrine system diseases ,Endocrinology, Diabetes and Metabolism ,Biopsy ,Biopsy, Fine-Needle ,Papillary ,Settore MED/08 - Anatomia Patologica ,RET/PTC ,Settore MED/13 - Endocrinologia ,Thyroid carcinoma ,Cohort Studies ,Endocrinology ,Predictive Value of Tests ,Carcinoma ,medicine ,80 and over ,Humans ,Thyroid Neoplasms ,Aged ,RET/PTC Rearrangement ,Aged, 80 and over ,Gene Rearrangement ,medicine.diagnostic_test ,business.industry ,Proto-Oncogene Proteins c-ret ,Gene rearrangement ,Middle Aged ,medicine.disease ,Carcinoma, Papillary ,Amino Acid Substitution ,Fine-Needle ,Female ,Braf ,BRAF V600E ,Fine-needle aspiration ,Mutation (genetic algorithm) ,business - Abstract
Objective: To evaluate BRAFV600E mutation on consecutive fine-needle aspiration biopsy (FNAB) specimens in order to assess FNAB’s usefulness in preoperative papillary thyroid carcinoma (PTC) diagnosis with the contemporaneous analysis of RET=PTC1 and RET=PTC3 rearrangements obtained from ex vivo thyroid nodules. Design: Thyroid FNABs from 156 subjects with nodules and 49 corresponding surgical samples were examined for the presence of BRAF mutation by real-time allele-specific polymerase chain reaction, confirmed with the use of a laser pressure catapulting system. Samples were also examined for RET=PTC rearrangements. The results were compared with the cytological diagnosis and histopathology. Main outcomes: 13=156 cytological examinations were diagnostic for PTC and 19=156 showed suspicious=indeterminate FNAB (12.2%). FNAB-BRAFV600E mutation was detected in 11=16 (69%) cases with histological confirmation of PTC. In our series, RET=PTC rearrangement was detected in only one case of PTC, whereas it was not present in any case of adenoma, goiter, or Hashimoto’s thyroiditis. No PTC case was found positive at the same time for BRAF mutation and RET=PTC rearrangements. Conclusion: BRAFV600E mutation detected on FNAB specimens, more than RET=PTC rearrangerangements, is highly specific for PTC and its routine research might well be an adjunctive and integrative diagnostic tool for the preoperative diagnostic iter.
- Published
- 2007
4. MALIGNANT MYOEPITHELIOMA OF THE BREAST - A CASE-HISTORY AND REVIEW OF LITERATURE
- Author
-
TOMASINO, RM, primary, TRALONGO, V, additional, NAGAR, C, additional, LATTERI, MA, additional, SALVATO, M, additional, NUARA, R, additional, DANIELE, E, additional, and MORELLO, V, additional
- Published
- 1994
- Full Text
- View/download PDF
5. SUBCUTANEOUS RECOMBINANT-HUMAN-ERYTHROPOIETIN PREVENTS CHEMOTHERAPY-RELATED ANEMIA IN PATIENTS WITH ADVANCED CANCER
- Author
-
GEBBIA, V, primary, GEBBIA, N, additional, TESTA, A, additional, VALENZA, R, additional, BORSELLINO, N, additional, RAUSA, L, additional, AGOSTARA, B, additional, CALLARI, A, additional, LATTERI, MA, additional, FLORENA, M, additional, CIPOLLA, C, additional, and LETO, G, additional
- Published
- 1992
- Full Text
- View/download PDF
6. Histological and histochemical changes in the colon mucosa after ureterosigmoidostomy or colonic conduit
- Author
-
Rosa Maria Tomasino, Orestano F, Morello, Spinnato G, Pantuso G, and Latteri Ma
- Subjects
Pathology ,medicine.medical_specialty ,Colon ,Urology ,medicine.medical_treatment ,Biopsy ,Sialomucins ,Colon mucosa ,Urinary Diversion ,Ureterosigmoidostomy ,Intestinal mucosa ,Colon, Sigmoid ,Risk Factors ,medicine ,Humans ,Intestinal Mucosa ,Aged ,Staining and Labeling ,business.industry ,Mucin ,Urinary diversion ,Mucins ,Middle Aged ,medicine.disease ,Epithelium ,Precancerous condition ,medicine.anatomical_structure ,business - Abstract
A study was made of 22 patients previously subjected to urinary diversion, 12 with ureterosigmoidostomy and 10 with colon conduit. The histological and histochemical examination of biopsies of intestinal mucosa near to and far from the ureteral orifices showed transformations with considerable inflammatory infiltration, variations in the composition of the acid mucins with a prevalence of sialomucins, lengthening and branching of the glandular crypts, and sometimes dysplasias of the epithelium. These structural modifications are typical of transitional mucosa. Transitional mucosa might reflect an aspecific reaction of the intestinal mucosa or alternatively it might signify a precancerous condition. Its presence in intestinal diversions suggests the advisability of careful follow-up in all patients subjected to this operation.
- Published
- 1988
7. Percutaneous radiofrequency thermal ablation of small hepatocellular carcinoma: A prospective study
- Author
-
Di Marco, V., Sandonato, L., Orlando, A., Parisi, P., Alizzi, S., Schepis, F., Di Bona, D., Albanese, M., Sciarrino, E., Virdone, R., Pardo, S., Sergio Salerno, Cabibi, D., Pagliaro, L., Latteri, Ma, and Craxi, A.
8. Giant hepatocellular adenoma as cause of severe abdominal pain: a case report
- Author
-
Sandonato Luigi, Cipolla Calogero, Graceffa Giuseppa, Bartolotta Tommaso V, Li Petri Sergio, Ciacio Oriana, Cannizzaro Fabio, and Latteri Mario A
- Subjects
Medicine - Abstract
Abstract The authors describe the case of a large hepatocellular adenoma diagnosed in a 30-year old woman who came to us complaining of acute pain in the upper abdominal quadrants. The patient had been taking an oral contraceptive pill for the last ten years. We present the clinical features, the diagnostic work-up and the treatment prescribed.
- Published
- 2007
- Full Text
- View/download PDF
9. Secretory breast carcinoma with metastatic sentinel lymph node
- Author
-
Graceffa Giuseppa, Fricano Salvatore, Cipolla Calogero, Cabibi Daniela, Vieni Salvatore, and Latteri Mario
- Subjects
Surgery ,RD1-811 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Secretory mammary carcinoma is a rare breast neoplasia originally described in children but sometimes also found in adults. It presents a more favourable outcome than more common histological types of breast carcinoma; published literature in fact reports only a few cases with axillary lymph node metastases and only four cases with distant metastases. Clinical presentation In this paper we report a rare case of secretory breast carcinoma with axillary lymph node metastases in a 33-year-old woman. To our knowledge, this is the first case of secretory carcinoma involving biopsy of the sentinel lymph node and investigation of the e-cadherin expression. We found positivity for e-cadherin, which would support the hypothesis that this type of tumour is a variant of the infiltrating ductal carcinoma. Conclusion After a careful analysis of reported data, we have come to the conclusion that the treatment of choice for patients with secretory breast carcinoma should be conservative surgery with sentinel lymph node biopsy, followed by accurate follow-up. We are of the opinion that while post-operative radiotherapy is indicated in adult patients who have undergone quadrantectomy, it should not be used in children. Although several cases of secretory carcinoma have been treated with adjuvant chemotherapy, there are still no reliable data regarding the real value of such a choice.
- Published
- 2006
- Full Text
- View/download PDF
10. Mitochondrion at the Crossroad Between Nutrients and Epigenome
- Author
-
Mario Adelfio Latteri, Mario G. Mirisola, Antonio Russo, Giusi Taormina, and Taormina G, Russo A, Latteri MA, Mirisola MG.
- Subjects
0301 basic medicine ,Endocrinology, Diabetes and Metabolism ,Mini Review ,nutrition and epigenome ,030209 endocrinology & metabolism ,Mitochondrion ,lcsh:Diseases of the endocrine glands. Clinical endocrinology ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,nutrients and epigenome ,mitochondria and metabolism ,Epigenetic Profile ,FMD and epigenome ,Epigenetics ,lcsh:RC648-665 ,biology ,mitochondrion, epigenetics, metabolism ,Mechanism (biology) ,Chemistry ,Epigenome ,Methylation ,Chromatin ,Cell biology ,030104 developmental biology ,Histone ,calorie restriction and epigenome ,biology.protein - Abstract
Epigenetic profile is the link between the regulation of nuclear gene expression and the environment. The most important factors capable of significantly affecting the cellular environment are the amount and quality of nutrients available. Mitochondria are both involved in the production of some of the molecules capable of directly affecting the epigenome and have a critical role in the conversion of nutrients into usable energy. Carbohydrate and fats are converted into ATP, acetyl-CoA, SAM, and NADH. These high-energy substrates are, in turn, capable of driving the epigenetic profile. We describe substances capable of affecting this mechanism. On the other hand, nutritional interventions capable of reducing calories or significantly impairing the normal Acetyl-CoA production or the SAM-SAH ratio also impact chromatin methylation and histone modification, suggesting a critical role of mitochondria on nutrient-dependent epigenetic profile.
- Published
- 2019
11. L'impiego del Tachosil in chirurgia epatica
- Author
-
SANDONATO, Luigi, VALERIO, Maria Rosaria, PARDO, Salvatore, ROMANO, Pietro, LOMBARDO, Giuseppina, CABIBBO, Giuseppe, BOVA, Valentina, TERRANOVA, Angela, RIZZO, Marta, LATTERI, Mario, SANDONATO L, VALERIO MR, PARDO S, ROMANO P, LOMBARDO G, CABIBBO G, BOVA V, TERRANOVA A, RIZZO M, and LATTERI MA
- Subjects
Settore MED/18 - Chirurgia Generale ,resezione epatica, emostasi - Abstract
Il controllo delle perdite ematiche intra e post-operatorie caratterizza da sempre la chirurgia resettiva epatica. Nel corso degli ultimi anni notevoli progressi sono stati compiuti in tale ambito, grazie all'adozione di materiali e strumentari sempre più specifici ed efficaci che consento l'esecuzione di interventi resettivi con minime perdite ematiche ed una significativa riduzione dell'incidenza di complicanze emorragiche post-operatorie. Vengono presentati 2 casi di resezione epatica realizzata utilizzando un manipolo a radiofrequenza senza eseguire il clampaggio del peduncolo epatico e senza l'utilizzo di clips o legature per le piccole perdite dalla trancia di sezione. Un buon controllo dell'emostasi sulla trancia di sezione è stato ottenuto intraoperatoriamente mediante l'utilizzo di spugne medicate (fibrinogeno umano + trombina umana), la cui indicazione è stata estesa anche a pazienti che non presentavano significative perdite ematiche intraoperatorie allo scopo di ridurre il rischio di sanguinamenti nel postoperatorio (in considerazione del tipo di emostasi realizzata, basata quasi esclusivamente sulla necrosi coagulativa indotta sulla trancia epatica mediante radiofrequenza).
- Published
- 2009
12. Mortality in patients with hepatocellular carcinoma predicted by six scoring: none is the winner
- Author
-
CAMMA', Calogero, DI MARCO, Vito, CABIBBO, Giuseppe, LATTERI, Federica, SANDONATO L, PARISI, Pietro, ALESSI N, LICATA, Anna, GALIA G, ENEA, Marco, ATTANASIO, Massimo, LATTERI, Mario, CRAXI, Antonio, CAMMA' C, DI MARCO V, CABIBBO G, LATTERI F, SANDONATO L, PARISI P, ALESSI N, LICATA A, GALIA G, ENEA M, ATTANASIO M, LATTERI MA, and CRAXI' A
- Subjects
Periodontal microcirculation, capillaroscopy, rheumatoid arthritis - Published
- 2007
13. Seeding after radiofrequency thermal ablation of hepatocellular carcinoma in cirrhosis: a prospective study
- Author
-
LATTERI, Federica, SANDONATO, Luigi, DI MARCO, Vito, PARISI, Pietro, CABIBBO, Giuseppe, LATTERI, Mario, CRAXI, Antonio, LOMBARDO G, GALIA M, LATTERI F, SANDONATO L, DI MARCO V, PARISI P, CABIBBO G, LOMBARDO G, GALIA M, LATTERI MA, and CRAXI' A
- Published
- 2007
14. L'RFTA nel trattamento dell'epatocarcinoma su cirrosi
- Author
-
BOVA, Valentina, LATTERI, Federica, SANDONATO, Luigi, PARISI, Pietro, CANNIZZARO, Francesco, MIDIRI, Massimo, LATTERI, Mario, BOVA V, LATTERI F, SANDONATO L, PARISI P, CANNIZZARO F, MIDIRI M, and LATTERI MA
- Published
- 2007
15. Radio-frequency thermal ablation (RFTA) of small hepatocellular carcinoma in patients with cirrhosis. Experience at a single tertiary referral center
- Author
-
A, Licata, V, Di Marco, P, Parisi, F, Latteri, M E, Nebbia, G, Cabibbo, D, Di Bona, G, Prinzi, S, Li Petri, L, Sandonato, M A, Latteri, A, Craxì, C, Cammà, Licata, A, Di Marco, V, Parisi, P, Latteri, F, Nebbia, ME, Cabibbo, G, Di Bona, D, Prinzi, G, Li Petri, S, Sandonato, L, Latteri, MA, Craxì, A, and Cammà, C
- Subjects
Liver Cirrhosis ,Male ,Carcinoma, Hepatocellular ,hepatocellular carcinoma, thermal ablation ,Liver Neoplasms ,Hyperthermia, Induced ,Cancer Care Facilities ,Middle Aged ,Survival Analysis ,Disease-Free Survival ,Treatment Outcome ,Italy ,Catheter Ablation ,Humans ,Female ,Prospective Studies ,Aged - Abstract
AIM: Radio-frequency thermal ablation (RFTA) may prolong the survival of patients with small hepatocellular carcinoma (HCC) associated with cirrhosis. The aim of this study was to evaluate efficacy and safety of RFTA. METHODS: We performed the Kaplan-Meier analysis to estimate the survival rate in 69 consecutive patients with HCC (mean age 66+/-6.5 years; 44/25 male/female; 56 Child-Pugh class A and 13 Child-Pugh class B) treated by RFTA. A single lesion was observed in 60/69 (87%), two lesions in 8/69 (11.6 %), and 3 lesions in 1/69 (1.4 %) of patients. The tumor size was = or
- Published
- 2005
16. Il trattamento delle lesioni epatiche primitive e secondarie con termoablazione mediante radiofrequenza
- Author
-
LATTERI, Mario, SANDONATO, Luigi, CIPOLLA, Calogero, LATTERI, Federica, LI PETRI S, CIACIO, Oriana, LATTERI MA, SANDONATO L, CIPOLLA C, LATTERI F, LI PETRI S, and CIACIO O
- Subjects
HCC, termoablazione - Published
- 2005
17. PERCUTANEOUS RADIOFREQUENCY THERMAL ABLATION 8 RFTA) OF SMALL HEPATOCELLUALR CARCINOMA: A PROSPECTIVE STUDY
- Author
-
CAMMA', Calogero, DI MARCO, Vito, SANDONATO, Luigi, PARISI, Pietro, CABIBI, Daniela, PARDO, Salvatore, MONTALTO, Giuseppe, LATTERI, Mario, ORLANDO A, SCIARRINO E, VIRDONE R, CASARIL A, DI BONA D, ALIZZI S, NICOLI, CAMMA C, DI MARCO V, ORLANDO A, SANDONATO L, PARISI P, SCIARRINO E, VIRDONE R, CASARIL A, CABIBI D, PARDO S, DI BONA D, ALIZZI S, MONTALTO G, LATTERI MA, and NICOLI
- Abstract
PERCUTANEOUS RADIOFREQUENCY THERMAL ABLATION 8 RFTA) OF SMALL HEPATOCELLUALR CARCINOMA: A PROSPECTIVE STUDY Data: 2004 Dettaglio tipologia d'Ateneo: 3a - Articoli su riviste ISI (anche on line)
- Published
- 2004
18. Il trattamento dell'HCC mediante RFTA
- Author
-
PRINZI, Gabriele, SANDONATO, Luigi, PARISI, Pietro, LATTERI, Federica, LATTERI, Mario, LI PETRI S, CIPOLLA, Calogero, BARTOLOTTA, Tommaso Vincenzo, PRINZI G, SANDONATO L, LI PETRI S, CIPOLLA C, PARISI P, BARTOLOTTA T, LATTERI F, and LATTERI MA
- Published
- 2004
19. L'impiego del Tissue-Link FB3.0 floating ball nelle resezioni epatiche
- Author
-
LI PETRI S, BOTTINO A, ALAIMO G, GALIA G, VIENI, Salvatore, SANDONATO, Luigi, PRINZI, Gabriele, CABIBBO, Giuseppe, LATTERI, Mario, LI PETRI S, SANDONATO L, PRINZI G, BOTTINO A, ALAIMO G, GALIA G, CABIBBO G, VIENI S, and LATTERI MA
- Published
- 2004
20. Tattica chirurgica nel trattamento delle neoplasie maligne della tiroide
- Author
-
LATTERI, Mario, SANDONATO, Luigi, CIPOLLA, Calogero, GRACEFFA G., LAGALLA R., LATTERI M.A., ATTARD M., MIDIRI M., LATTERI MA, CIPOLLA C, SANDONATO L, and GRACEFFA G
- Published
- 2004
21. Percutaneous radiofrequency therma ablation of small hepatocellular carcinoma: a prospective study
- Author
-
CAMMA', Calogero, DI MARCO, Vito, PARISI, Pietro, PARDO, Salvatore, MONTALTO, Giuseppe, LATTERI, Mario, CRAXI, Antonio, SANDONATO L, ORLANDO A, VIRDONE R, NICOLI N, CASARIL A, CABIBBI D, ALIZZI S, DI BONA D, CAMMA C, DI MARCO V, PARISI P, SANDONATO L, ORLANDO A, VIRDONE R, NICOLI N, CASARIL A, CABIBBI D, PARDO S, ALIZZI S, DI BONA D, MONTALTO G, LATTERI MA, and CRAXI A
- Published
- 2004
22. p53 mutations in L3-loop zinc-binding domain, DNA-ploidy, and S phase fraction are independent prognostic indicators in colorectal cancer: A prospective study with a five-year follow-up
- Author
-
Russo, A., Migliavacca, M., Zanna, I., Valerio, M. R., Latteri, M. A., Grassi, N., Pantuso, G., Sergio Salerno, Dardanoni, G., Albanese, I., La Farina, M., Tomasino, R. M., Gebbia, N., Bazan, V., Russo, A, Migliavacca, M, Zanna, I, Valerio, MR, Latteri, MA, Grassi, N, Pantuso, G, Salerno, S, Dardanoni, G, Albanese, I, La Farina, M, Tomasino, RM, Gebbia, N, and Bazan, V
- Subjects
Male ,Settore MED/06 - Oncologia Medica ,protein p53 ,S Phase ,Biomarkers, Tumor ,Humans ,Prospective Studies ,Codon ,Aged ,Ploidies ,Polymorphism, Genetic ,DNA, Neoplasm ,Exons ,DNA ,Middle Aged ,Genes, p53 ,Prognosis ,Survival Analysis ,Protein Structure, Tertiary ,Italy ,Multivariate Analysis ,Mutation ,Female ,Carrier Proteins ,Colorectal Neoplasms ,Follow-Up Studies - Abstract
p53 gene alterations are among the most common events observed in colorectal cancer,and are accompanied frequently by DNA aneuploidy and high proliferative activity. The prognostic significance of such mutations remains controversial. We prospectively evaluated the prognostic significance of p53 mutations, DNA-ploidy, and S phase fraction (SPF) in a consecutive series of 160 colorectal cancer patients (median follow-up 71 months). Tumor DNA was screened for p53 mutations by PCR/single-strand conformational polymorphism/sequencing. DNA-ploidy and SPF were assessed by DNA flow cytometry. p53 mutations were detected in 68 of 160 (42.5%) cases. In 56% (38 of 68) of these, p53 mutations were found in conserved areas of the gene and in 44% (30 of 68 cases) outside the conserved regions. Eighteen of the 68 cases (26%) had mutations in the L3 loop, 11 of 68 (16%) in the L1 loop-sheet-alpha helix motif, and 39 of 68 (58%) outside L3 and loop-sheet-alpha helix. Seventy-five percent of the cases (120 of 160) showed DNA aneuploidy, whereas 18% of these (22 of 120) were multiclonal. The major independent predictors for both disease relapse and death were advanced Dukes' stage, p53 mutations affecting L3 loop, DNA-aneuploid tumors, and high SPF (18.5%). Our results show that mutations in L3 functional domain, more than any mutations, are important biological indicators to predict the outcome of patients indicating that these mutations have biological relevance in terms of colorectal cancer disease course.
- Published
- 2002
23. Diagnostica e significato delle linfoadenopatie inguino-crurali
- Author
-
SPINNATO, G, PIAZZA, Giovanni, VIENI, Salvatore, LATTERI, Mario, M.A.Latteri e coll., SPINNATO, G, PIAZZA, G, VIENI, S, and LATTERI, MA
- Subjects
Settore MED/18 - Chirurgia Generale ,linfoadenopatie inguino-crurali - Published
- 2001
24. Tumori della mammella
- Author
-
LATTERI, Mario, VIENI, Salvatore, CIPOLLA, Calogero, AMATO, C, FRICANO, S, M.A. Latteri e coll., LATTERI, MA, CIPOLLA, C, AMATO, C, FRICANO, S, and VIENI, S
- Subjects
Settore MED/18 - Chirurgia Generale ,carcinoma mammario - Published
- 2001
25. Intraepidermal perianal Paget’s disease
- Author
-
GIAMMANCO, Marco, VIENI, S, BECCHINA, G, PANTUSO, Gianni, FLORENA, Ada Maria, LATTERI, Mario, GIAMMANCO, M, PANTUSO, G, FLORENA, AM, VIENI, S, BECCHINA, G, and LATTERI, MA
- Subjects
Settore MED/18 - Chirurgia Generale ,Extramammary Paget's disease - perianal Paget's disease - Paget's cells - Abstract
the Autthors report a case of localised perianal Paget's disease consisting of an eczematous lesion unresponsive to steroid anal treatment subsequently treated with local excision. the patient after 20 months is alive and presents no further signs of disease. The Authors therefore point out that in elderly patients with stage I perianal Paget's disease local wide excision is considered the best therapeutical choice.
- Published
- 1999
26. Short term intensive preoperative chemotherapy with high doses of epirubicin plus G-CSF rescue for locally advanced Stage III breast carcinoma
- Author
-
GEBBIA, Vittorio, LATTERI, Mario, CIPOLLA, Calogero, Agostara, B, Valenza, R, Comandè, S, Callari, A, Blasi, L, Buccellato, C, Gebbia, N., Gebbia, V, Latteri, MA, Agostara, B, Valenza, R, Comandè, S, Callari, A, Blasi, L, Cipolla, C, Buccellato, C, and Gebbia, N
- Subjects
Settore MED/18 - Chirurgia Generale ,Settore MED/06 - Oncologia Medica ,Breast carcinoma, preoperative chemotherapy, G.CSF - Published
- 1996
27. La terapia adiuvante nelle pazienti affette da carcinoma mammario con linfonodi ascellari negativi. Attuale ruolo dei fattori prognostici nella condotta terapeutica
- Author
-
LATTERI, Mario, CIPOLLA, Calogero, Latteri, MA, and Cipolla, C
- Subjects
Breast cancer, axillary lymph nodes - Published
- 1994
28. Indication et limites du traitement par la L-Thyroxine dans la prophylaxie de la récidive après exérèse chirurgical pour pathologie thyroidienne bénigne a foncionnement normal
- Author
-
CIPOLLA, Calogero, GRACEFFA, Giuseppa, Amato, C, Salanitro, L, BAJARDI, Guido, LATTERI, Mario, Cipolla, C, Graceffa, G, Amato, C, Salanitro, L, Bajardi, G, and Latteri, MA
- Subjects
Settore MED/18 - Chirurgia Generale ,L-Thyroxine, Pathologie Thyroïdienne ,Settore MED/13 - Endocrinologia - Published
- 1993
29. Subcutaneous recombinant human erythropoietin prevents chemotherapy-related anemia in patients with advanced cancer
- Author
-
GEBBIA, Vittorio, LATTERI, Mario, CIPOLLA, Calogero, LETO, Gaetano, Gebbia, N, Testa, A, Valenza, R, Borsellino, N, Rausa, L, Agostara, B, Callari, A, Florena, M, Gebbia, V, Gebbia, N, Testa, A, Valenza, R, Borsellino, N, Rausa, L, Agostara, B, Callari, A, Latteri, MA, Florena, M, Cipolla, C, and Leto G
- Subjects
erythropoietin, anemia, advanced cancer - Published
- 1992
30. Combination chemotherapy of 5-fluorouracil, epidoxorubicin and mitomycin C in the palliative treatment of locally advanced and/or metastatic adenocarcinoma of the stomach
- Author
-
Florena M, Antonio Testa, Mario Adelfio Latteri, G. Bajardi, G. Mastrandrea, G. Curto, Nicolo' Gebbia, Calogero Cipolla, Vittorio Gebbia, Pischedda G, Roberto Valenza, G Cannata, Gebbia, V, Testa, A, Valenza, R, Latteri, MA, Bajardi, G, Mastrandrea, G, Cipolla, C, Pischedda, G, Curto, G, Cannata, G, Gebbia, N, and Florena, M
- Subjects
Adult ,Male ,medicine.medical_specialty ,Mitomycin ,medicine.medical_treatment ,Adenocarcinoma ,Gastric Adenocarcinoma, Chemotherapy, Epidoxorubicin, Mitomicin C ,Gastroenterology ,Stomach Neoplasms ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,Pharmacology (medical) ,Neoplasm Metastasis ,Aged ,Epirubicin ,Aged, 80 and over ,Pharmacology ,Chemotherapy ,business.industry ,Stomach ,Palliative Care ,Mitomycin C ,Combination chemotherapy ,Middle Aged ,medicine.disease ,Confidence interval ,Surgery ,Infectious Diseases ,medicine.anatomical_structure ,Oncology ,Fluorouracil ,Female ,business ,Progressive disease ,medicine.drug - Abstract
Thirty-seven consecutive patients with advanced and/or metastatic gastric adenocarcinoma received a combination of 5-fluorouracil 600 mg/m2 on days 1, 8, 29, 36; epidoxorubicin 75 mg/m2 i.v. on days 1, 29; mitomycin C 10 mg/m2 i.v. on day 1. This cycle was repeated every 8 weeks. Out of a total of 34 evaluable patients, 2 (5.8%) had a complete response and 7 (20.6%) had a partial response with an overall median duration of 40 weeks (range 20-128). The median survival of responding patients was not reached after a mean follow-up of 76 weeks, while that of patients with no change and progressive disease was reached at 36 and 13 weeks respectively. Treatment was generally well tolerated with hematological and gastrointestinal toxicities being the major side-effects. Despite the use of epidoxorubicin 75 mg/m2, the 26.4% (95% confidence limits 16-36%) objective response rate is not satisfactory. Evaluation of more aggressive protocols is strongly recommended within the limits of controlled trials.
31. Minor hepatic resection using heat coagulative necrosis
- Author
-
Luigi Sandonato, Calogero Cipolla, Terranova A, Giuseppe Lo Re, Achille Mastrosimone, Giuseppe Cabibbo, Fabio Fulfaro, Valentina Bova, Mario Adelfio Latteri, Federica Latteri, Sandonato, L, Cipolla, C, Fulfaro, F, Lo Re, G, Latteri, F, Terranova, A, Mastrosimone, A, Bova, V, Cabibbo, G, and Latteri, MA
- Subjects
Male ,medicine.medical_specialty ,Necrosis ,Blood transfusion ,Carcinoma, Hepatocellular ,Colorectal cancer ,medicine.medical_treatment ,Blood Loss, Surgical ,Hemoglobins ,medicine ,liver metastases, cancer, surgery ,Hepatectomy ,Humans ,Aged ,business.industry ,Liver Neoplasms ,General Medicine ,Length of Stay ,Middle Aged ,medicine.disease ,Hemostasis, Surgical ,Surgery ,Settore MED/18 - Chirurgia Generale ,Coagulative necrosis ,Hematocrit ,Hemostasis ,Anesthesia ,Hepatocellular carcinoma ,Catheter Ablation ,Female ,medicine.symptom ,Complication ,business - Abstract
Intra- and postoperative bleeding represents an extremely serious and frequent complication of hepatic surgery. In this study, we evaluated the effectiveness of a radiofrequency (RF) device using heat to cause coagulative necrosis of the hepatic parenchyma to control hemostasis in minor hepatic resection. Between December 2005 and November 2007, a study was conducted of 21 patients undergoing 22 hepatic resections with the RF-assisted technique. Sixteen of these were affected by hepatocellular carcinoma and five had liver metastases from colorectal cancer. Intraoperative blood loss, the need for blood transfusion, the complication rates, operating times, and the duration of postoperative hospitalization were evaluated. Four segmentectomies and 18 tumorectomies were performed. The average blood loss was of 15.7 mL (range, 0-40 mL); the average operating time was 25.7 minutes (range, 12-43 minutes); the mean postoperative hospital stay was 8.2 days (range, 3-49 days) with a median of 6.0 days. The authors concluded that the RF-assisted technique can be a useful method not only for reducing blood loss and avoiding blood transfusions, but also for reducing operating time and postoperative hospitalization for minor liver resections.
32. Vinorelbine plus cisplatinum for the treatment of stage IIIB and IV non small cell lung carcinoma
- Author
-
GEBBIA, Vittorio, Caruso, M, Valenza, R, Testa, A, Cannata, G, Verderame, F, CIPOLLA, Calogero, Curto, G, Oliveri, D, Chiarenza, M, LATTERI, Mario, Di Gesù, G, Gebbia, N., Gebbia, V, Caruso, M, Valenza, R, Testa, A, Cannata, G, Verderame, F, Cipolla, C, Curto, G, Oliveri, D, Chiarenza, M, Latteri, MA, Di Gesù, G, and Gebbia, N
- Subjects
Male ,Lung Neoplasms ,Settore MED/06 - Oncologia Medica ,Vinorelbine ,Middle Aged ,Vinblastine ,Lung carcinoma, Chemotherapy ,Settore MED/18 - Chirurgia Generale ,Carcinoma, Non-Small-Cell Lung ,Antineoplastic Combined Chemotherapy Protocols ,Humans ,Female ,Cisplatin ,Aged ,Neoplasm Staging - Abstract
Thirty consecutive patients with stage IIIB-IV non small cell lung cancer were treated with a combination of cisplatin 80 mg/m2 on day 1 plus vinorelbine 25-30 mg/m2 on days 1, 8. This cycle was repeated every 3 weeks. The overall response rate was 46%, with 1 patient showing a complete response and 13 patients (43%) a partial response with a mean duration of 8.4+ months. Six patients had a stabilization and 10 progressed. The main toxicities were represented by myelosuppression and nausea/vomiting. Grade 3 leukopenia was seen in 33% of cases, grade 2 thrombocytopenia in 12%, and phlebitis in the injection vein in 16%. Mild constipation was also recorded. The combination of cisplatin plus vinorelbine is quite effective in advanced non small cell carcinoma of the lung, and may be safely given on an outpatient basis.
33. Laparoscopic versus robotic right colectomy with extra-corporeal or intra-corporeal anastomosis: a systematic review and meta-analysis.
- Author
-
Genova P, Pantuso G, Cipolla C, Latteri MA, Abdalla S, Paquet JC, Brunetti F, de'Angelis N, and Di Saverio S
- Subjects
- Anastomosis, Surgical, Colectomy, Humans, Length of Stay, Operative Time, Prospective Studies, Retrospective Studies, Treatment Outcome, Laparoscopy, Robotic Surgical Procedures adverse effects
- Abstract
Purpose: The aim of the present systematic review and meta-analysis is to compare laparoscopic right colectomy (LRC) versus robotic right colectomy (RRC) using homogeneous subgroup analyses for extra-corporeal anastomosis (EA) and intra-corporeal anastomosis (IA)., Methods: MEDLINE, Scopus, and Web of Science databases were searched up to April 2020 for prospective or retrospective studies comparing LRC versus RRC on at least one short- or long-term outcome. The primary outcome was the length of hospital stay (LOS). The secondary outcomes included operative and pathological results, survival, and total costs. LRC and RRC were compared using three homogeneous subgroups: without distinction by the type of anastomosis, EA only, and IA only. Pooled data analyses were performed using mean difference (MD) and random effects model., Results: Thirty-seven of 448 studies were selected. The included patients were 21,397 for the LRC group and 2796 for the RRC group. Regardless for the type of anastomosis, RRC showed shorter LOS, lower blood loss, lower conversion rate, shorter time to flatus, and lower overall complication rate compared with LRC, but longer operative time and higher total costs. In the EA subgroup, RRC showed similar LOS, longer operative time, and higher costs compared with LRC, the other outcomes being similar. In the IA subgroup, RRC showed shorter LOS and longer operative time compared with LRC, with no difference for the remaining outcomes., Conclusions: Most included articles are retrospective, providing low-quality evidence and limiting conclusions. The more frequent use of the IA seems to explain the advantages of RRC over LRC., (© 2020. Springer-Verlag GmbH Germany, part of Springer Nature.)
- Published
- 2021
- Full Text
- View/download PDF
34. Safety and Feasibility of Robotic-Assisted Drainage of Symptomatic Pancreatic Pseudocysts: A Case-Series Analysis (with video).
- Author
-
Marino MV, Heng AK, Mirabella A, Potapov O, Vaccarella G, Latteri MA, and Komorowski AL
- Subjects
- Drainage, Feasibility Studies, Humans, Neoplasm Recurrence, Local, Retrospective Studies, Treatment Outcome, Pancreatic Pseudocyst surgery, Robotic Surgical Procedures adverse effects
- Abstract
Background: The surgical treatment of pancreatic pseudocysts (PPs) in patients who fail nonoperative management has evolved from aggressive open to a minimally invasive approach. The application of robotic surgery in this setting is scarcely reported. The aim of this study is to analyze the safety and feasibility of the robotic approach to pancreatic pseudocyst drainage. Methods: A single centre retrospective review of consecutive patients undergoing robotic-assisted pancreatic pseudocyst surgeries in an academic tertiary institution was performed. Results: There were 14 patients studied, of whom 10 underwent cystogastrostomy and 4 Roux-En- Y cystojejunostomy. Eight patients had gallstone pancreatitis and 3 patients alcoholic pancreatitis. The mean size of cyst was 8.9 +-1cm and 57.1% located at the pancreatic body. The overall operative time of the procedure was 135 +-34 minutes. There were no open conversions. The overall success rate was 92.8%, while the primary success rate 85.7%. The major morbidity rate was 14.3% and there was no 30-day mortality. The mean post-operative hospital stay was 7 +-3 days with one recurrence of the pancreatic pseudocyst on follow-up requiring endoscopic drainage without further recurrence. Conclusions: The robotic approach for the drainage of symptomatic pancreatic pseudocyst is safe and feasible and can be considered as a viable modality for operative intervention in well-selected patients., (Celsius.)
- Published
- 2021
- Full Text
- View/download PDF
35. Robotic-assisted pancreaticoduodenectomy with vascular resection. Description of the surgical technique and analysis of early outcomes.
- Author
-
Marino MV, Giovinazzo F, Podda M, Gomez Ruiz M, Gomez Fleitas M, Pisanu A, Latteri MA, and Takaori K
- Subjects
- Adenocarcinoma pathology, Aged, Female, Humans, Male, Middle Aged, Operative Time, Robotic Surgical Procedures statistics & numerical data, Treatment Outcome, Vascular Surgical Procedures statistics & numerical data, Pancreatic Neoplasms surgery, Pancreaticoduodenectomy methods, Pancreaticoduodenectomy statistics & numerical data, Robotic Surgical Procedures methods, Vascular Surgical Procedures methods
- Abstract
Background: Despite the potential benefits, the adoption of the minimally invasive surgery for the treatment of borderline resectable pancreatic cancer is still in the initial phase. We investigated the safety and feasibility of the robotic pancreaticoduodenectomy with venous resection/reconstruction (RPD SMV/PV)., Methods: Since March 2013 to October 2019, a total of 73 RPD and 10 RPD SMV/PV were performed. The two groups were case-matched according to the preoperative characteristics., Results: Mean operative times and estimated blood loss were less in the RPD group in comparison to that in the RPD with SMV-PV group (525 vs 642 min, p = 0.003 and 290 vs 620 ml, p = 0.002, respectively). The mean length of hospital stay was similar in the RPD group in comparison to that in the RPD with SMV-PV group (10 days vs 13 days, p = 0.313). The two groups had similar overall postoperative morbidity rate (57.5% vs 60%, p = 0.686), although the severe complication rate was lower in the RPD group (11% vs 40%, p = 0.004)., Conclusions: RPD with SMV-PV is associated with increased operative time, estimated blood loss, higher major complication rate compared with RPD., (Copyright © 2020 Elsevier Ltd. All rights reserved.)
- Published
- 2020
- Full Text
- View/download PDF
36. Tangential Venous Resections during Robotic-Assisted Pancreaticoduodenectomy: the Results of a Case Series (with Video).
- Author
-
Marino MV, Latteri MA, and Ahmad A
- Subjects
- Humans, Mesenteric Veins surgery, Pancreatectomy, Pancreaticoduodenectomy adverse effects, Portal Vein surgery, Retrospective Studies, Treatment Outcome, Pancreatic Neoplasms surgery, Robotic Surgical Procedures adverse effects
- Abstract
Introduction: Despite the potential advantages in terms of microdissection and microsuturing capabilites, the robotic approach for borderline resectable pancreatic cancer is scarcely reported., Methods: We report our technique for a robotic-assisted pancreaticoduodenectomy with tangential Portal/ Superior Mesenteric Vein resection/reconstruction (RPD PV/SMV).We also compared the surgical outcomes of eight consecutive patients undergoing RPD PV/SMV with that of sixty patients who underwent robotic-assisted pancreaticoduodenectomy (RPD) in the same period of time., Results: A total of eight consecutive patients underwent RPD PV/SMV. We observed an increased estimated blood loss (550 vs 280 mL, p = 0.003) and operative time (438 vs 350 min, p = 0.002) in the RPD PV/SMV group of patients compared with RPD group, whereas the complication rate (28% vs 31%, p = 0.726) was similar. No venous-congestion related complications were observed in the postoperative course. The median length of hospital stay was similar in the RPD group in comparison to that in the RPD PV/SMV group (10 vs 13 range 6-19 days, p = 0.313)., Conclusion: RPD PV/SMV is a challenging operation. It is associated with higher operative time and increased estimated blood loss in comparison to standard RPD.
- Published
- 2020
- Full Text
- View/download PDF
37. Mitochondrion at the Crossroad Between Nutrients and Epigenome.
- Author
-
Taormina G, Russo A, Latteri MA, and Mirisola MG
- Abstract
Epigenetic profile is the link between the regulation of nuclear gene expression and the environment. The most important factors capable of significantly affecting the cellular environment are the amount and quality of nutrients available. Mitochondria are both involved in the production of some of the molecules capable of directly affecting the epigenome and have a critical role in the conversion of nutrients into usable energy. Carbohydrate and fats are converted into ATP, acetyl-CoA, SAM, and NADH. These high-energy substrates are, in turn, capable of driving the epigenetic profile. We describe substances capable of affecting this mechanism. On the other hand, nutritional interventions capable of reducing calories or significantly impairing the normal Acetyl-CoA production or the SAM-SAH ratio also impact chromatin methylation and histone modification, suggesting a critical role of mitochondria on nutrient-dependent epigenetic profile., (Copyright © 2019 Taormina, Russo, Latteri and Mirisola.)
- Published
- 2019
- Full Text
- View/download PDF
38. An evaluation score of the difficulty of thyroidectomy considering operating time and preservation of recurrent laryngeal nerve.
- Author
-
Vieni S, Graceffa G, Rizzo GEM, Latteri F, Latteri MA, and Cipolla C
- Subjects
- Adult, Aged, Aged, 80 and over, Clinical Competence statistics & numerical data, Female, Humans, Male, Middle Aged, Operative Time, Prospective Studies, Recurrent Laryngeal Nerve Injuries epidemiology, Recurrent Laryngeal Nerve Injuries etiology, Thyroid Diseases pathology, Thyroid Diseases surgery, Thyroid Gland pathology, Thyroid Gland surgery, Young Adult, Clinical Competence standards, Recurrent Laryngeal Nerve surgery, Thyroidectomy methods, Thyroidectomy statistics & numerical data
- Abstract
The purpose of this study was to edit a renovated thyroidectomy difficulty scale (rTDS) in order to identify underlying thyroid diseases with a longer operative time and higher technical difficulty, also considering preservation of recurrent laryngeal nerve. We developed a renovated scale with a maximum score of 20 points by creating a form in which five variables were considered: vascularity, friability, mobility/fibrosis, gland size and difficulty in preservation of the recurrent laryngeal nerve. Two surgeons separately evaluated each of these. Through a simple linear regression analysis, we have analyzed the relationship between rTDS score and operative times, and between rTDS score and preservation of recurrent nerve. Eventually, Spearman's rank correlation coefficient has been used in order to evaluate our double-blind study. Our cohort included 131 patients undergoing total thyroidectomy. The mean of the rTDS was 9.00 ± 3.67 for Surgeon A and 8.31 ± 3.42 for Surgeon B, with Spearman's rank correlation coefficient between surgeons of 0.85 (p < 0.0001). We have shown that the rTDS score significantly influences the operating times (R
2 = 0.44 for surgeon A, R2 = 0.46 for B, p < 0.0001 for both). Moreover, we can say that the rTDS score significantly influences preservation of the recurrent nerve (R2 = 0.37, Beta 0.61, 8.84 t test, p < 0.0001). Our rTDS is a useful tool and, thanks to it, we identified hyperthyroidism and goiter as the hardest underlying disease for surgery. Thus our scale could change operative approach, resulting in better surgeries' scheduling and identification of pathologies that require higher attention.- Published
- 2019
- Full Text
- View/download PDF
39. Denosumab for bone health in prostate and breast cancer patients receiving endocrine therapy? A systematic review and a meta-analysis of randomized trials.
- Author
-
Galvano A, Scaturro D, Badalamenti G, Incorvaia L, Rizzo S, Castellana L, Cusenza S, Cutaia S, Santini D, Guadagni F, Roselli M, Gori S, Latteri MA, Bazan V, Giulia LM, and Russo A
- Abstract
Hormonal therapies for receptor positive-breast and prostate cancer patients have shown clinical efficacy but also several side effects including osteoporosis, loss of bone mass and increased fracture risk. Denosumab represents an anti RANKL (receptor activator of nuclear factor-kB ligand) monoclonal anti-body acting as inhibitor of osteoclasts formation, function, and survival, then increasing bone mass. Herein, we performed a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the role of Denosumab in saving bone health in prostate and breast cancer patients receiving respectively androgen deprivation therapy and adjuvant endocrine therapy. Moreover, selected patients have to be treated with Denosumab at the dose of 60 mg every six month or placebo. Outcomes studied included the bone mass density (BMD) increase at 24 and 36 months, BMD loss, reduction of fractures risk (in particular vertebral) at 24 and 36 months and safety (overall, serious adverse events - SAEs and discontinuation rate). Our results showed a reduction of the BMD loss up to 36 months both at the lumbar and femoral level and a BMD increase both at 24 and 36 months. It was also found a reduction in the number of new vertebral and femoral fractures at 24 and 36 months. Finally, our pooled analysis showed that Denosumab did not affect both the SAEs and therapy discontinuation risk. In conclusion, Denosumab administration can be considered effective and safe in the prevention and management of the above mentioned adverse events related to hormonal therapies designed for breast and prostate tumors.
- Published
- 2019
- Full Text
- View/download PDF
40. Ultrasound-Guided Breast-Conservative Surgery Decreases the Rate of Reoperations for Palpable Breast Cancer.
- Author
-
Vieni S, Graceffa G, Priola R, Fricano M, Latteri S, Latteri MA, and Cipolla C
- Subjects
- Adult, Aged, Aged, 80 and over, Breast Neoplasms pathology, Carcinoma pathology, Female, Humans, Margins of Excision, Middle Aged, Palpation, Reoperation, Retrospective Studies, Treatment Outcome, Breast Neoplasms diagnostic imaging, Breast Neoplasms surgery, Carcinoma diagnostic imaging, Carcinoma surgery, Mastectomy, Segmental, Ultrasonography, Mammary
- Abstract
The purpose of this study is to verify whether the performance of ultrasound-guided quadrantectomy (USGQ) versus palpation-guided quadrantectomy (PGQ) can reduce the incidence of positive margins and if it can change the attitude of the surgeon. A retrospective study was conducted on 842 patients underwent quadrantectomy for breast cancer, 332 of them underwent USGQ, whereas 550 underwent PGQ. The histological type of the tumors and the margin status obtained with the histological examination were compared. The histological examination of the surgical specimen showed involvement of the margins in 24/842 patients (2.85%), 22 (2.61%) of them belonged to the PGQ group, and two to the USGQ group (P = 0.0011). The highest rate of microscopically positive margins was, statistically significant, for carcinoma in situ, when compared with patients with invasive carcinoma (0.0001). USGQ technique showed several advantages compared with PGQ. In fact, the former notes a lower positive margin rate and, consequently, a lower rate of reintervention. In addition, it may change the surgeon's attitude by causing him to remove another slice of margin to ensure more histological negativity. It should be the gold standard technique for breast-conservative surgery of palpable tumors.
- Published
- 2018
41. Thyroid metastases from renal cell carcinoma. Report of a case and review of the literature.
- Author
-
Graceffa G, Vieni S, Barbagallo MV, Ferrara G, Cipolla C, and Latteri MA
- Abstract
Metastases to thyroid gland are a rare occurrence in surgical practice. The most frequent primitive tumor is renal cell carcinoma. We report a case of thyroid metastasis from renal cell carcinoma in a 70-year-old man who underwent left nephrectomy ten years earlier, presented with a diagnosis of multinodular goiter, associated with thyroiditis and right laterocervical lymphadenopathy. A total and the surgical excision of laterocervical lymph node were performed. The results, according to the histological examination, were metastases from renal cell carcinoma, involving both the thyroid gland and the lymph node. Therefore, since the delay of presentation and the difficulties of diagnosis, we recommend log-term follow-up of the head and neck region, for those patients with renal cell carcinoma diagnosis.
- Published
- 2018
42. Application of a predictive model of axillary lymph node status in patients with sentinel node metastasis from breast cancer. A retrospective cohort study.
- Author
-
Vieni S, Graceffa G, La Mendola R, Latteri S, Cordova A, Latteri MA, and Cipolla C
- Subjects
- Adult, Aged, Aged, 80 and over, Area Under Curve, Axilla pathology, Breast Neoplasms surgery, Cohort Studies, Female, Humans, Lymphatic Metastasis, Middle Aged, Models, Theoretical, Nomograms, ROC Curve, Retrospective Studies, Risk Assessment, Sensitivity and Specificity, Breast Neoplasms pathology, Lymph Node Excision methods, Lymph Nodes pathology, Sentinel Lymph Node pathology, Sentinel Lymph Node Biopsy methods
- Abstract
Background and Objectives: The Axillary Lymph Node Dissection (ALND) is the standard treatment in patients with invasive breast cancer and sentinel node metastasis, but in 60% of the cases there is no further axillary neoplastic involvement, so this invasive intervention represents an overtreatment. The purpose of the study is to identify patients with low risk of additional nodal metastases, to omit ALND., Methods: The MSKCC Additional nodal metastasis nomogram was applied on a sample of 175 patients with invasive breast cancer who underwent ALND after detection of macrometastasis with the extemporaneous examination of the sentinel lymph node. Patients were classified as "low risk" when the result of the nomogram was ≤50%. Sensitivity, specificity, positive and negative predictive values and AUC (Area Under Curve) of the ROC curve of the nomogram were then calculated., Results: A cut-off by 50% yielded 92.3% sensitivity, 81,4% specificity, 80% positive predictive value and 92.9% negative predictive value. The ROC curve AUC in these patients was 0.885., Conclusions: The MSKCC nomogram has proven to be an effective tool in estimating the axillary lymph node status and it can potentially be used to better select the patients with sentinel node macrometastasis who can actually benefit from ALND., (Copyright © 2016 IJS Publishing Group Ltd. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2016
- Full Text
- View/download PDF
43. Lymphoscintigraphy with peritumoral injection versus lymphoscintigraphy with subdermal periareolar injection of technetium-labeled human albumin to identify sentinel lymph nodes in breast cancer patients.
- Author
-
Caruso G, Cipolla C, Costa R, Morabito A, Latteri S, Fricano S, Salerno S, and Latteri MA
- Subjects
- Adult, Aged, Aged, 80 and over, Breast Neoplasms pathology, Breast Neoplasms surgery, Female, Humans, Image Enhancement methods, Injections, Intralesional, Middle Aged, Radiopharmaceuticals, Retrospective Studies, Technetium Tc 99m Aggregated Albumin, Breast Neoplasms diagnostic imaging, Lymphoscintigraphy methods, Sentinel Lymph Node Biopsy
- Abstract
Background: Preoperative lymphoscintigraphy is without doubt a valid method for the detection of the sentinel lymph node (SLN). There has been considerable debate regarding the optimal site for the introduction of the tracer; various sites include peritumoral (PT), periareolar (PA), subdermal, and intradermal injection., Purpose: To evaluate retrospectively the lymphoscintigraphic identification rate of peritumoral (PT) injection versus subdermal periareolar (PA) injection in the detection of SLNs in breast cancer., Material and Methods: Between October 2002 and December 2011, a cohort of 906 consecutive patients with biopsy proven breast cancer underwent 914 SLN biopsy procedures. A total of 339 procedures (Group A) were performed using a PT deep injection of radiotracer while 575 procedures (Group B) adopted a subdermal PA injection of radiotracer towards the upper outer quadrant, regardless of the site of the carcinoma. All the patients underwent synchronous excision of the breast cancer and SLN biopsy., Results: SLNs were identified in the lymphoscintigram in 308/339 cases (90.85%) of Group A (PT injection) and in 537/575 cases (93.39%) of Group B (PA injection). Furthermore, in 2/339 patients (0.58%) of Group A, internal mammary lymph nodes were found at lymphoscintigraphy, whereas no internal mammary sentinel nodes were found in the Group B patients. The intraoperative identification rate of axillary SLNs was 99.41% (337 of 339) in the Group A patients and 99.65% (573 of 575) in the Group B patients. There was no significant difference in the two groups between the incidence of the number of SLNs detected and the incidence of identification of positive SLNs., Conclusion: PT versus PA injection of radiotracer showed comparable success rates for axillary SLN identification, and can be considered a rapid and reliable method.
- Published
- 2014
- Full Text
- View/download PDF
44. Primary schwannoma of the thyroid gland involving the isthmus: report of a case.
- Author
-
Graceffa G, Cipolla C, Florena AM, Gentile I, Pompei G, and Latteri MA
- Subjects
- Humans, Male, Middle Aged, Neurilemmoma diagnosis, Neurilemmoma pathology, Thyroid Gland surgery, Thyroid Neoplasms diagnosis, Thyroid Neoplasms pathology, Thyroidectomy, Treatment Outcome, Neurilemmoma surgery, Thyroid Gland pathology, Thyroid Neoplasms surgery
- Abstract
Primary thyroid schwannomas are extremely rare tumors and there are very few reports of such tumors in the literature. This report presents a rare case of schwannoma involving the isthmus of the thyroid in a 47-year-old male, presenting as a symptomatic predominating cold nodule within a multinodular goiter. The patient underwent total thyroidectomy. The histological examination indicated an Antoni A-type schwannoma. The clinical, radiological and pathological findings of the tumor are discussed, emphasizing the difficulty in reaching a correct preoperative diagnosis. Only 18 cases of primary schwannoma of the thyroid gland have so far been described in the literature and, this is only the second report of thyroid schwannoma localized in the isthmus.
- Published
- 2013
- Full Text
- View/download PDF
45. Validity of shape memory NiTi colon ring BioDynamix ColonRing™ (or NiTi CAR 27™) to prevent anastomotic colorectal strictures. Preliminary results.
- Author
-
Grassi N, Cipolla C, Bottino A, Graceffa G, Montana L, Privitera C, Grassi R, and Latteri MA
- Subjects
- Colectomy, Constriction, Pathologic, Humans, Rectum surgery, Anastomosis, Surgical, Colon surgery
- Abstract
Purpose: Anastomotic strictures occur in 3-30% of colorectal anastomosis and one of the main causes may be a reaction to the presence of the metal staples used for suturing. The aim of this study was to evaluate the efficacy of a compression anastomosis ring using the memory shaped device in initial, i.e. nickel-titanium alloy (NiTi) for the prevention of colorectal anastomotic strictures., Patients and Methods: A compression anastomosis ring device (NiTi CAR 27™) was used to perform compression anastomosis in 20 patients underwent left hemicolectomy and anterior resection of the rectum for carcinoma. An endoscopic check of the anastomosis was carried out at one month and at six months after surgery., Results: In 2 patients (10%) a dehiscence of the anastomosis occurred on the fifth and the eighth postoperative day. No anastomotic strictures were observed in any of the other 18 patients at six months follow-up after surgery., Conclusion: Our preliminary results suggest that the use of a compression anastomosis ring might well be a valid method of preventing anastomotic strictures in colorectal surgery. Further studies involving a larger number of patients are needed in order to confirm these preliminary results.
- Published
- 2012
46. BRAFV600E mutation, TIMP-1 upregulation, and NF-κB activation: closing the loop on the papillary thyroid cancer trilogy.
- Author
-
Bommarito A, Richiusa P, Carissimi E, Pizzolanti G, Rodolico V, Zito G, Criscimanna A, Di Blasi F, Pitrone M, Zerilli M, Amato MC, Spinelli G, Carina V, Modica G, Latteri MA, Galluzzo A, and Giordano C
- Subjects
- Adult, Amino Acid Substitution physiology, Carcinoma, Carcinoma, Papillary, Cell Transformation, Neoplastic pathology, Disease Progression, Female, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Gene Regulatory Networks physiology, Glutamic Acid genetics, Humans, Male, Middle Aged, Mutation, Missense physiology, Neoplasm Invasiveness, Proto-Oncogene Proteins B-raf physiology, Signal Transduction genetics, Signal Transduction physiology, Thyroid Cancer, Papillary, Thyroid Neoplasms pathology, Tissue Inhibitor of Metalloproteinase-1 metabolism, Tumor Cells, Cultured, Up-Regulation genetics, Valine genetics, Cell Transformation, Neoplastic genetics, NF-kappa B metabolism, Proto-Oncogene Proteins B-raf genetics, Thyroid Neoplasms genetics, Thyroid Neoplasms metabolism, Tissue Inhibitor of Metalloproteinase-1 genetics
- Abstract
BRAF(V600E) is the most common mutation found in papillary thyroid carcinoma (PTC). Tissue inhibitor of metalloproteinases (TIMP-1) and nuclear factor (NF)-κB have been shown to play an important role in thyroid cancer. In particular, TIMP-1 binds its receptor CD63 on cell surface membrane and activates Akt signaling pathway, which is eventually responsible for its anti-apoptotic activity. The aim of our study was to evaluate whether interplay among these three factors exists and exerts a functional role in PTCs. To this purpose, 56 PTC specimens were analyzed for BRAF(V600E) mutation, TIMP-1 expression, and NF-κB activation. We found that BRAF(V600E) mutation occurs selectively in PTC nodules and is associated with hyperactivation of NF-κB and upregulation of both TIMP-1 and its receptor CD63. To assess the functional relationship among these factors, we first silenced BRAF gene in BCPAP cells, harboring BRAF(V600E) mutation. We found that silencing causes a marked decrease in TIMP-1 expression and NF-κB binding activity, as well as decreased invasiveness. After treatment with specific inhibitors of MAPK pathway, we found that only sorafenib was able to increase IκB-α and reduce both TIMP-1 expression and Akt phosphorylation in BCPAP cells, indicating that BRAF(V600E) activates NF-κB and this pathway is MEK-independent. Taken together, our findings demonstrate that BRAF(V600E) causes upregulation of TIMP-1 via NF-κB. TIMP-1 binds then its surface receptor CD63, leading eventually to Akt activation, which in turn confers antiapoptotic behavior and promotion of cell invasion. The recognition of this functional trilogy provides insight on how BRAF(V600E) determines cancer initiation, progression, and invasiveness in PTC, also identifying new therapeutic targets for the treatment of highly aggressive forms.
- Published
- 2011
- Full Text
- View/download PDF
47. Minor hepatic resection for hepatocellular carcinoma in cirrhotic patients: Kelly clamp crushing resection versus heat coagulative necrosis with bipolar radiofrequency device.
- Author
-
Sandonato L, Soresi M, Cipolla C, Bartolotta TV, Giannitrapani L, Antonucci M, Galia M, and Latteri MA
- Subjects
- Aged, Carcinoma, Hepatocellular pathology, Equipment Design, Female, Follow-Up Studies, Humans, Laparotomy, Liver surgery, Liver Neoplasms pathology, Male, Necrosis, Retrospective Studies, Surgical Instruments, Time Factors, Treatment Outcome, Blood Loss, Surgical prevention & control, Carcinoma, Hepatocellular surgery, Catheter Ablation instrumentation, Hemostasis, Surgical instrumentation, Hepatectomy methods, Liver pathology, Liver Neoplasms surgery
- Abstract
Hemorrhage and postoperative liver insufficiency are frequent and serious complications of hepatic resection in cirrhotic patients. The aim of this study was to assess retrospectively whether the surgical techniques using Kelly clamp crushing resection or heat coagulative necrosis with a bipolar radiofrequency device can reduce the incidence of the above complications and an eventual recurrence of neoplasia on the liver slice. We retrospectively reviewed the results of 35 patients who had undergone resection for monofocal hepatocellular carcinoma at our center. Thirteen patients (Group A) had undergone liver resection with Kelly clamp crushing resection, 22 patients (Group B) had had liver resection assisted with a bipolar radiofrequency device. Radiofrequency-assisted liver resection was associated with diminished blood loss (P < 0.0001), a lower blood transfusion rate (P < 0.005), reduced operative time (P < 0.0001), and better postoperative serum albumin levels (P < 0.03). This nonrandomized retrospective study suggests that radiofrequency-assisted liver resection is associated with better results than the Kelly clamp crushing resection technique in cirrhotic patients with focal hepatocellular carcinoma and preserved liver function. These results should now be assessed prospectively in a randomized clinical trial.
- Published
- 2011
48. Local neck symptoms before and after thyroidectomy: a possible correlation with reflux laryngopharyngitis.
- Author
-
Fiorentino E, Cipolla C, Graceffa G, Cusimano A, Cupido F, Lo Re G, Matranga D, and Latteri MA
- Subjects
- Adult, Aged, Female, Goiter, Nodular complications, Goiter, Nodular diagnosis, Humans, Laryngitis complications, Male, Middle Aged, Pharyngitis complications, Young Adult, Deglutition Disorders etiology, Goiter, Nodular surgery, Laryngopharyngeal Reflux complications, Thyroidectomy adverse effects, Voice Disorders etiology
- Abstract
Local symptoms in the neck such as swallowing and voice disorders, and throat discomfort might be related to a goiter if present, but are also reported by patients suffering from reflux laryngopharyngitis. The aim of our study was to investigate the presence of reflux laryngopharyngitis in patients with nodular goiter before and after uncomplicated total thyroidectomy (TT) using a prospective study in University Hospital setting. We considered 25 patients, affected by non-toxic nodular goiter and candidates for TT, who complained of local symptoms in the neck. All the patients were carefully interviewed, with emphasis on swallowing and voice disorders, throat discomfort and reflux-related symptoms and underwent a videolaryngoscopy (VLS) and a videofluoroscopic swallowing study (VFSS) before and 3 months after TT. Before thyroidectomy, reflux laryngopharyngitis-related alterations were present in 68 and 50% at VLS and VFSS, respectively. After thyroidectomy, the swallowing and voice disorders persisted in 79 and 75%, respectively, while throat discomfort persisted in 91%. The results show that patients with a non-toxic nodular goiter who complain of local neck symptoms, before surgery it is appropriate to see if a reflux laryngopharyngitis is present; VLS and VFSS could be indicated for this and if necessary an antireflux treatment should be administered., (© Springer-Verlag 2010)
- Published
- 2011
- Full Text
- View/download PDF
49. [Hemostatic effectiveness of TachoSil® patches in radiofrequency assisted minor hepatic resection].
- Author
-
Sandonato L, Cipolla C, Airò Farulla C, Graceffa G, Giannitrapani L, Galia M, Lombardo G, Ferro G, Lodato L, and Latteri MA
- Subjects
- Adult, Aged, Aged, 80 and over, Combined Modality Therapy, Drug Combinations, Female, Humans, Male, Middle Aged, Catheter Ablation, Fibrinogen, Hemostatic Techniques, Hepatectomy methods, Liver Diseases surgery, Surgical Sponges, Thrombin
- Abstract
Aim: Intra- and postoperative bleeding represents an extremely serious and frequent complication of hepatic surgery. The aim of this study was to evaluate the effectiveness of TachoSil® to improve hemostasis in radiofrequency assisted minor hepatic resection., Methods: Between July 2008 and June 2010, 31 patients underwent radiofrequency assisted minor hepatic resection. At the end of the liver resection a sponge of TachoSil® was applied on the liver., Results: The mean intraoperative bleeding from the liver was 56.1 mL (range 0-300 mL). No patients received intra- and postoperative blood transfusion. Surgical drains were removed between the first and the sixth-eight postoperative day., Conclusion: According to the authors Tacho-sil® is helpful to improve hemostasis and biliary leakage in patients undergoing radiofrequency assisted minor hepatic resection.
- Published
- 2010
50. The value of intraoperative frozen section examination of sentinel lymph nodes in surgical management of breast carcinoma.
- Author
-
Cipolla C, Cabibi D, Fricano S, Vieni S, Gentile I, and Latteri MA
- Subjects
- Adult, Aged, Aged, 80 and over, Axilla pathology, Breast pathology, Breast Neoplasms surgery, Carcinoma, Ductal, Breast surgery, Carcinoma, Lobular surgery, Female, Frozen Sections, Humans, Intraoperative Period, Lymph Node Excision, Lymphatic Metastasis, Mastectomy, Middle Aged, Neoplasm Staging, Reproducibility of Results, Retrospective Studies, Sensitivity and Specificity, Breast Neoplasms pathology, Carcinoma, Ductal, Breast pathology, Carcinoma, Lobular pathology, Lymph Nodes pathology, Sentinel Lymph Node Biopsy
- Abstract
Purpose: In breast cancer staging, the need for intraoperative sentinel lymph node (SLN) evaluation has still not been adequately established. This study investigates the impact of intraoperative frozen section (FS) evaluation of SLN to avoid subsequent axillary lymph node dissection (ALND) in patients with positive SLN., Methods: A retrospective review of 364 breast cancer patients undergoing SLN biopsy with intraoperative FS evaluation of SLN was performed., Results: Sensitivity and accuracy of FS examination of SLN were 76.4% and 94.2%, respectively. The sensitivity was significantly higher in larger tumors (p < 0.01). No significant correlation was found between FS and histologic type. A second intervention was avoided in 83.9% of the patients with positive SLN., Conclusions: Intraoperative FS examination of the SLN is a useful predictor of axillary lymph node status in breast cancer patients. The majority of SLN-positive patients allows for immediate ALND in a one-stage surgical procedure.
- Published
- 2010
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.