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31 results on '"Lattanzio, Stefano"'

1. Cellular Strategies for Separating GvHD from GvL in Haploidentical Transplantation

Author

Di Ianni, Mauro, primary, Liberatore, Carmine, additional, Santoro, Nicole, additional, Ranalli, Paola, additional, Guardalupi, Francesco, additional, Corradi, Giulia, additional, Villanova, Ida, additional, Di Francesco, Barbara, additional, Lattanzio, Stefano, additional, Passeri, Cecilia, additional, Lanuti, Paola, additional, and Accorsi, Patrizia, additional

Published
2023
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3. Cellular Strategies for Separating GvHD from GvL in Haploidentical Transplantation.

Author

Di Ianni, Mauro, Liberatore, Carmine, Santoro, Nicole, Ranalli, Paola, Guardalupi, Francesco, Corradi, Giulia, Villanova, Ida, Di Francesco, Barbara, Lattanzio, Stefano, Passeri, Cecilia, Lanuti, Paola, and Accorsi, Patrizia

Subjects
REGULATORY T cells, SUICIDE, CELLULAR therapy, GENE therapy, BRAIN death
Abstract

GvHD still remains, despite the continuous improvement of transplantation platforms, a fearful complication of transplantation from allogeneic donors. Being able to separate GvHD from GvL represents the greatest challenge in the allogeneic transplant setting. This may be possible through continuous improvement of cell therapy techniques. In this review, current cell therapies are taken into consideration, which are based on the use of TCR alpha/beta depletion, CD45RA depletion, T regulatory cell enrichment, NK-cell-based immunotherapies, and suicide gene therapies in order to prevent GvHD and maximally amplify the GvL effect in the setting of haploidentical transplantation. [ABSTRACT FROM AUTHOR]

Published
2024
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4. LIGHT/TNFSF14 is increased in patients with type 2 diabetes mellitus and promotes islet cell dysfunction and endothelial cell inflammation in vitro

Author

Halvorsen, Bente, Santilli, Francesca, Scholz, Hanne, Sahraoui, Afaf, Gulseth, Hanne L., Wium, Cecilie, Lattanzio, Stefano, Formoso, Gloria, Di Fulvio, Patrizia, Otterdal, Kari, Retterstøl, Kjetil, Holven, Kirsten B., Gregersen, Ida, Stavik, Benedicte, Bjerkeli, Vigdis, Michelsen, Annika E., Ueland, Thor, Liani, Rossella, Davi, Giovanni, and Aukrust, Pål

Published
2016
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10. Pentraxin 3 and Platelet Activation in Obese Patients After Gastric Banding

Author

Santilli, Francesca, primary, Guagnano, Maria Teresa, additional, Innocenti, Paolo, additional, Aceto, Liberato, additional, Vazzana, Natale, additional, Lattanzio, Stefano, additional, Liani, Rossella, additional, Tripaldi, Romina, additional, Creato, Valeria, additional, Romano, Mario, additional, and Davì, Giovanni, additional

Published
2016
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12. Circulating Myeloid‐Related Protein–8/14 is Related to Thromboxane‐Dependent Platelet Activation in Patients With Acute Coronary Syndrome, With and Without Ongoing Low‐Dose Aspirin Treatment

Author

Santilli, Francesca, primary, Paloscia, Leonardo, additional, Liani, Rossella, additional, Di Nicola, Marta, additional, Di Marco, Massimo, additional, Lattanzio, Stefano, additional, La Barba, Sara, additional, Pascale, Silvia, additional, Mascellanti, Marco, additional, and Davì, Giovanni, additional

Published
2014
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13. Circulating Dickkopf‐1 in Diabetes Mellitus: Association With Platelet Activation and Effects of Improved Metabolic Control and Low‐Dose Aspirin

Author

Lattanzio, Stefano, primary, Santilli, Francesca, additional, Liani, Rossella, additional, Vazzana, Natale, additional, Ueland, Thor, additional, Di Fulvio, Patrizia, additional, Formoso, Gloria, additional, Consoli, Agostino, additional, Aukrust, Pål, additional, and Davì, Giovanni, additional

Published
2014
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14. Platelet Cyclooxygenase Inhibition by Low-Dose Aspirin Is Not Reflected Consistently by Platelet Function Assays. Implications for Aspirin 'Resistance'

Author

Santilli, Francesca, Rocca, Bianca, De Cristofaro, Raimondo, Lattanzio, Stefano, Pietrangelo, Laura, Habib, Aida, Pettinella, Caterina, Recchiuti, Antonio, Ferrante, Elisabetta, Ciabattoni, Giovanni, Davì, Giovanni, Patrono, Carlo, Rocca, Bianca (ORCID:0000-0001-8304-6423), De Cristofaro, Raimondo (ORCID:0000-0002-8066-8849), Santilli, Francesca, Rocca, Bianca, De Cristofaro, Raimondo, Lattanzio, Stefano, Pietrangelo, Laura, Habib, Aida, Pettinella, Caterina, Recchiuti, Antonio, Ferrante, Elisabetta, Ciabattoni, Giovanni, Davì, Giovanni, Patrono, Carlo, Rocca, Bianca (ORCID:0000-0001-8304-6423), and De Cristofaro, Raimondo (ORCID:0000-0002-8066-8849)

Abstract

Objective: This study was conducted to assess the thromboxane (TX) dependence of biochemical and functional indexes used to monitor the effect of low-dose aspirin. Background: Functional assays of the antiplatelet effects of low-dose aspirin variably reflect the TX-dependent component of platelet aggregation. Previous studies of aspirin resistance were typically based on a single determination of platelet aggregation. Methods: We assessed the TXB2 dependence of biochemical and functional indexes, as well as their intersubject and intrasubject variability during administration of the drug and after its withdrawal in 48 healthy volunteers randomized to receive aspirin 100 mg daily for 1 to 8 weeks. Results: Serum TXB2 was uniformly suppressed by 99% of baseline. Urinary 11-dehydro-TXB2, arachidonic acid-induced aggregation, and VerifyNow Aspirin (Accumetrics Inc., San Diego, California) showed stable, incomplete inhibition (65%, 80%, and 35%, respectively). Adenosine diphosphate- and collagen-induced aggregation was highly variable and poorly affected by aspirin, with an apparent time-dependent reversal. Inhibition of platelet cyclooxygenase activity was nonlinearly related to inhibition of platelet aggregation. Platelet function largely recovered by day 3 post-aspirin, independently of treatment duration. With any functional assay, occasionally "resistant" subjects were found to be "responders" on previous or subsequent determinations. Conclusions: Platelet cyclooxygenase activity, as reflected by serum TXB2 levels, is uniformly and persistently suppressed by low-dose aspirin in healthy subjects. However, the effect of aspirin is variably detected by functional assays, potentially leading to misclassification of "responder" as "resistant" phenotypes owing to poor reproducibility of functional measurements. The nonlinearity of the relationship between inhibition of TX production and inhibition of platelet function has important clinical implications. © 2009 American C

Published
2009

18. C0389 Inflammation, oxidative stress and platelet activation in aspirin-treated critical limb ischaemia: Beneficial effects of iloprost

Author

Vazzana, Natale, primary, Lessiani, Gianfranco, additional, Cuccurullo, Chiara, additional, Di Michele, Dario, additional, Laurora, Giuseppe, additional, Sgrò, Giuseppe, additional, Di Ruscio, Paolo, additional, Simeone, Emilio, additional, Di Iorio, Pierangelo, additional, Lattanzio, Stefano, additional, Liani, Rossella, additional, and Davì, Giovanni, additional

Published
2012
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23. Inflammation, oxidative stress and platelet activation in aspirin-treated critical limb ischaemia: Beneficial effects of iloprost

Author

Cuccurullo, Chiara, primary, Di Michele, Dario, primary, Laurora, Giuseppe, primary, Sgrò, Giuseppe, primary, Di Ruscio, Paolo, primary, Simeone, Emilio, primary, Di Iorio, Pierangelo, primary, Lattanzio, Stefano, primary, Liani, Rossella, primary, Ferrante, Elisabetta, primary, Lessiani, Gianfranco, additional, Vazzana, Natale, additional, and Davì, Giovanni, additional

Published
2011
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24. Abstract 5011: The Contribution of COX-1 and COX-2 to Platelet Activation in Essential Thrombocythemia: A Clinical Paradigm of Aspirin-resistant Thromboxane Biosynthesis

Author

Rocca, Bianca, primary, Dragani, Alfredo, additional, Pascale, Silvia, additional, Recchiuti, Antonio, additional, Mattoscio, Domenico, additional, Lattanzio, Stefano, additional, Petrucci, Giovanna, additional, Mucci, Luciana, additional, Ferrante, Elisabetta, additional, Habib, Aida, additional, Ranelletti, Franco Oreste, additional, Davì, Giovanni, additional, and Patrono, Carlo, additional

Published
2009
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25. Platelet Cyclooxygenase Inhibition by Low-Dose Aspirin Is Not Reflected Consistently by Platelet Function Assays

Author

Santilli, Francesca, primary, Rocca, Bianca, additional, De Cristofaro, Raimondo, additional, Lattanzio, Stefano, additional, Pietrangelo, Laura, additional, Habib, Aida, additional, Pettinella, Caterina, additional, Recchiuti, Antonio, additional, Ferrante, Elisabetta, additional, Ciabattoni, Giovanni, additional, Davì, Giovanni, additional, and Patrono, Carlo, additional

Published
2009
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26. ASPIRIN-INSENSITIVE THROMBOXANE BIOSYNTHESIS IN POLYCYTHEMIA VERA

Author

Santilli, Francesca, primary, Romano, Mario, additional, Recchiuti, Antonio, additional, Dragani, Alfredo, additional, Falco, Angela, additional, Lessiani, Gianfranco, additional, Fioritoni, Francesca, additional, Lattanzio, Stefano, additional, Mattoscio, Domenico, additional, Rocca, Bianca, additional, and Davì, Giovanni, additional

Published
2008
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27. DETERMINANTS OF PLATELET ACTIVATION IN HEART FAILURE

Author

Santilli, Francesca, primary, Basili, Stefania, additional, Lattanzio, Stefano, additional, Cavoni, Adele, additional, Guizzardi, Giuseppe, additional, De Feudis, Lucrezia, additional, Traisci, Giancarlo, additional, Ciabattoni, Giovanni, additional, Davì, Giovanni, additional, and Patrono, Carlo, additional

Published
2008
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28. Stress-induced salivary cortisol secretion during hypobaric hypoxia challenge and in vivo urinary thromboxane production in healthy male subjects.

Author

Simeoni, Simona, Biselli, Roberto, D'Amelio, Raffaele, Rocca, Bianca, Lattanzio, Stefano, Mucci, Luciana, DavÌ, Giovanni, and Patacchioli, Francesca Romana

Subjects
HYDROCORTISONE, PHYSIOLOGICAL stress, SALIVARY glands, SECRETION, HYPOXEMIA, URINALYSIS, THROMBOXANES, HYPOBARISM
Abstract

Few studies have assessed the effects of stress on in vivo platelet activation. In the present study, hypobaric hypoxia induced by rapid decompression during high-altitude simulated flight in a hypobaric chamber was used to evaluate the effects of environmental stress on salivary cortisol and urinary thromboxane metabolite (TXM) excretion, a noninvasive marker of in vivo platelet function. Twenty-one male aviators (mean  ±±  SD age  ==  36  ±±  7 years) experiencing hypoxia by removing their oxygen mask for 4--5  min during a simulated flight to 25,000  ft (7,620  m; pO2  ==  59.17  mmHg) and a matched control group of thirteen flying instructors wearing oxygen masks during the challenge, were studied. Hypobaric hypoxia induced a transient significant increase ( P  <  0.001) in the aviators' salivary cortisol concentration; the overall pattern of diurnal cortisol fluctuation was maintained in both groups. Urinary TXM showed a significant ∼∼30% reduction ( P  <  0.01) after the chamber session in aviators exposed to hypobaric hypoxia, but not in controls. A significant inverse correlation was found between salivary cortisol and urinary TXM in aviators ( r  ==  −−  0.64, P  ==  0.0015). Salivary cortisol was a significant predictor ( P  <  0.001) for urinary TXM concentrations in aviators. In conclusion, here we observed that an acute stress-induced salivary cortisol increase was associated with reduced urinary thromboxane biosynthesis, providing the first indirect evidence for an inhibitory effect of acute stress on in vivo platelet function. [ABSTRACT FROM AUTHOR]

Published
2011
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30. Platelet Cyclooxygenase Inhibition by Low-Dose Aspirin Is Not Reflected Consistently by Platelet Function Assays Implications for Aspirin 'Resistance'

Author

Santilli, Francesca, Rocca, Bianca, De Cristofaro, Raimondo, Lattanzio, Stefano, Pietrangelo, Laura, Habib, Aida, Pettinella, Caterina, Recchiuti, Antonio, Ferrante, Elisabetta, Ciabattoni, Giovanni, Davì, Giovanni, and Patrono, Carlo

Subjects
prostaglandins, aspirin, platelets, antiplatelet drugs, pharmacology
Abstract

ObjectiveThis study was conducted to assess the thromboxane (TX) dependence of biochemical and functional indexes used to monitor the effect of low-dose aspirin.BackgroundFunctional assays of the antiplatelet effects of low-dose aspirin variably reflect the TX-dependent component of platelet aggregation. Previous studies of aspirin resistance were typically based on a single determination of platelet aggregation.MethodsWe assessed the TXB2dependence of biochemical and functional indexes, as well as their intersubject and intrasubject variability during administration of the drug and after its withdrawal in 48 healthy volunteers randomized to receive aspirin 100 mg daily for 1 to 8 weeks.ResultsSerum TXB2was uniformly suppressed by 99% of baseline. Urinary 11-dehydro-TXB2, arachidonic acid-induced aggregation, and VerifyNow Aspirin (Accumetrics Inc., San Diego, California) showed stable, incomplete inhibition (65%, 80%, and 35%, respectively). Adenosine diphosphate- and collagen-induced aggregation was highly variable and poorly affected by aspirin, with an apparent time-dependent reversal. Inhibition of platelet cyclooxygenase activity was nonlinearly related to inhibition of platelet aggregation. Platelet function largely recovered by day 3 post-aspirin, independently of treatment duration. With any functional assay, occasionally “resistant” subjects were found to be “responders” on previous or subsequent determinations.ConclusionsPlatelet cyclooxygenase activity, as reflected by serum TXB2levels, is uniformly and persistently suppressed by low-dose aspirin in healthy subjects. However, the effect of aspirin is variably detected by functional assays, potentially leading to misclassification of “responder” as “resistant” phenotypes owing to poor reproducibility of functional measurements. The nonlinearity of the relationship between inhibition of TX production and inhibition of platelet function has important clinical implications.

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