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3. Comprehensive genomic profiling by liquid biopsy captures tumor heterogeneity and identifies cancer vulnerabilities in patients with RAS/BRAFV600E wild-type metastatic colorectal cancer in the CAPRI 2-GOIM trial

Author

Ciardiello, Davide, Bielo, Luca Boscolo, Napolitano, Stefania, Martinelli, Erika, Troiani, Teresa, Nicastro, Antonella, Latiano, Tiziana Pia, Parente, Paola, Maiello, Evaristo, Avallone, Antonio, Normanno, Nicola, Pisconti, Salvatore, Nisi, Claudia, Bordonaro, Roberto, Russo, Alessia Erika, Tamburrini, Emiliano, Toma, Ilaria, Lotesoriere, Claudio, Vallarelli, Simona, Zampino, Maria Giulia, Fazio, Nicola, Curigliano, Giuseppe, Ciardiello, Fortunato, Martini, Giulia, Lonardi, Sara, Cremolini, Chiara, Garufi, Carlo, Tagliaferri, Pierosandro, Tortora, Giampaolo, Pietrantonio, Filippo, Febbraro, Antonio, Rosati, Gerardo, Leo, Silvana, Brunetti, Oronzo, Berardi, Rosanna, Cinieri, Saverio, Scartozzi, Mario, Zaniboni, Alberto, Paoletti, Giancarlo, Ciardiello, D., Boscolo Bielo, L., Napolitano, S., Martinelli, E., Troiani, T., Nicastro, A., Latiano, T.P., Parente, P., Maiello, E., Avallone, A., Normanno, N., Pisconti, S., Nisi, C., Bordonaro, R., Russo, A.E., Tamburini, E., Toma, I., Lotesoriere, C., Vallarelli, S., Zampino, M.G., Fazio, N., Curigliano, G., De Vita, F., Ciardiello, F., and Martini, G.

Published
2024
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4. Trop-2 and Nectin-4 immunohistochemical expression in metastatic colorectal cancer: searching for the right population for drugs’ development

Author

Moretto, Roberto, Germani, Marco Maria, Giordano, Mirella, Conca, Veronica, Proietti, Agnese, Niccoli, Cristina, Pietrantonio, Filippo, Lonardi, Sara, Tamburini, Emiliano, Zaniboni, Alberto, Passardi, Alessandro, Latiano, Tiziana Pia, Fanotto, Valentina, Di Donato, Samantha, Prisciandaro, Michele, Bergamo, Francesca, Masi, Gianluca, Fontanini, Gabriella, Ugolini, Clara, and Cremolini, Chiara

Published
2023
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5. Guideline Application in Real world: multi-Institutional Based survey of Adjuvant and first-Line pancreatic Ductal adenocarcinoma treatment in Italy. Primary analysis of the GARIBALDI survey

Author

Reni, Michele, Macchini, Marina, Orsi, Giulia, Peretti, Umberto, Valente, Mariamaddalena, Giommoni, Elisa, Antonuzzo, Lorenzo, Di Costanzo, Francesco, Bergamo, Francesca, Zagonel, Vittorina, Lonardi, Sara, Buggin, Federica, Milella, Michele, Palmerio, Silvia, Cavanna, Luigi, Di Nunzio, Camilla, Di Marco, Maria Cristina, Grassi, Elisa, Spada, Massimiliano, Messina, Marco, Cordio, Stefano, Avola, Francesco, Aprile, Giuseppe, Pagano, Salvatore, Simionato, Francesca, Cardellino, Giovanni Gerardo, Majer, Federica, Maiello, Evaristo, Latiano, Tiziana Pia, Chiarazzo, Cinzia, Artioli, Fabrizio, Razzini, Giorgia, Pasqualini, Antonella, Ghidini, Michele, Binda, Elisa, Lazzarelli, Silvia, Bozzarelli, Silvia, Sala, Simona, Luppi, Gabriele, Pettorelli, Elisa, Spallanzani, Andrea, Vicario, Giovanni, Salmaso, Flavia, Basso, Marco, Silvestris, Nicola, Del Curatolo, Sabina, Zustovich, Fable, Bongiovanni, Francesca, Longobardi, Ciro, Sandi, Ilenia, Fontanella, Caterina, Montelatici, Silvia, Giordano, Monica, Luchena, Giovanna, Gilardoni, Micol, Tamburini, Emiliano, Rudnas, Britt, Venturini, Barbara, Merelli, Barbara, Negrini, Giorgia, Vici, Elio Maria, Marabese, Alessandra, Garetto, Cristina, Curcio, Paola, Cinieri, Saverio, Cinefra, Margherita, Ferrara, Pasqualinda, Cantore, Maurizio, Morselli, Patrizia, Fumi, Guglielmo, Isidori, Agnese, Ciccarese, Giovanni, Paolo Frassineti, Giovanni Luca, Pagan, Flavia, Vaccaro, Vanja, Spoto, Chiara, Ferrara, Marianna, Garufi, Carlo, Caporale, Marta, Vasile, Enrico, Salani, Francesca, Barone, Elisa, Berardi, Rossana, Onofri, Azzurra, Ballatore, Zelmira, Lucarelli, Alessandra, Barucca, Alessandra, Pancotti, Amedeo, Scipioni, Teresa, Bencardino, Katia, Marrapese, Giovanna, Idotta, Laura, Petrelli, Fausto, Lonati, Veronica, Ceribelli, Anna, Giuli, Angelo, Zannori, Cristina, Bassanelli, Maria, Mambrini, Andrea, Ginocchi, Laura, Orlandi, Massimo, Celio, Luigi, Niger, Monica, Biamonte, Lavinia, Tamberi, Stefano, Piancastelli, Alessandra, Papiani, Giorgio, Valli, Irene, Allione, Paolo, Boe, Maria Giovanna, Scartozzi, Mario, Lai, Eleonora, Pireddu, Annagrazia, Ziranu, Pina, Demurtas, Laura, Puzzoni, Marco, Mariani, Stefano, Pretta, Andrea, Liscia, Nicole, Savastano, Clementina, Malaspina, Valentina, Tonini, Giuseppe, Grassani, Teresa, Barco, Barbara, Pierosandro, Tagliaferri, Ciliberto, Domenico, Ierardi, Antonella, Calandruccio, Natale Daniele, Minotti, Vincenzo, Matocci, Roberta, Torri, Valter, Porcu, Luca, Rulli, Erica, De Simone, Irene, Carlucci, Luciano, Rulli, Eliana, Poli, Davide, Tonto, Paola, Scellato, Francesca, Pinto, Carmine, Reni, M., Giommoni, E., Bergamo, F., Milella, M., Cavanna, L., Di Marco, M.C., Spada, M., Cordio, S., Aprile, G., Cardellino, G.G., Maiello, E., Bernardini, I., Ghidini, M., Bozzarelli, S., Macchini, M., Orsi, G., De Simone, I., Rulli, Er., Porcu, L., Torri, V., and Pinto, C.

Published
2023
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6. Ramucirumab plus paclitaxel as switch maintenance versus continuation of oxaliplatin-based chemotherapy in patients (pts) with advanced HER2-negative gastric or gastroesophageal junction (GEJ) cancer: The ARMANI phase III trial.

Author

Pietrantonio, Filippo, primary, Randon, Giovanni, additional, Lonardi, Sara, additional, Garattini, Silvio Ken, additional, Tamberi, Stefano, additional, Giommoni, Elisa, additional, Di Donato, Samantha, additional, Fornaro, Lorenzo, additional, Brunetti, Oronzo, additional, De Vita, Ferdinando, additional, Frassineti, Giovanni Luca, additional, Chini, Claudio, additional, Spallanzani, Andrea, additional, Bethaz, Valerie, additional, Strippoli, Antonia, additional, Latiano, Tiziana Pia, additional, Cardellino, Giovanni Gerardo, additional, Palermo, Federica, additional, Miceli, Rosalba, additional, and Di Bartolomeo, Maria, additional

Published
2024
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9. Duodenal Fluid Analysis as a Rewarding Approach to Detect Low-Abundance Mutations in Biliopancreatic Cancers.

Author

Tavano, Francesca, Latiano, Anna, Palmieri, Orazio, Gioffreda, Domenica, Latiano, Tiziana, Gentile, Annamaria, Tardio, Matteo, Latiano, Tiziana Pia, Gentile, Marco, Terracciano, Fulvia, and Perri, Francesco

Subjects
BIOMARKERS, CELL-free DNA, TUMOR markers, NUCLEOTIDE sequencing, PLASMA sources
Abstract

Diagnosis of biliopancreatic cancers by the available serum tumor markers, imaging, and histopathological tissue specimen examination remains a challenge. Circulating cell-free DNA derived from matched pairs of secretin-stimulated duodenal fluid (DF) and plasma from 10 patients with biliopancreatic diseases and 8 control subjects was analyzed using AmpliSeq™ HD technology for Ion Torrent Next-Generation Sequencing to evaluate the potential of liquid biopsy with DF in biliopancreatic cancers. The median cfDNA concentration was greater in DF-derived than in plasma-derived samples. A total of 13 variants were detected: 11 vs. 1 were exclusive for DF relative to the plasma source, and 1 was shared between the two body fluids. According to the four-tier systems, 10 clinical tier-I–II (76.9%), 1 tier–III (7.7%), and 2 tier–IV (15.4%) variants were identified. Notably, the 11 tier-I-III variants were exclusively found in DF-derived cfDNA from five patients with biliopancreatic cancers, and were detected in seven genes (KRAS, TP53, BRAF, CDKN2A, RNF43, GNAS, and PIK3CA); 82% of the tier-I-III variants had a low abundance, with a VAF < 6%. The mutational profiling of DF seems to be a reliable and promising tool for identifying cancer-associated alterations in malignant cancers of the biliopancreatic tract. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Upfront FOLFOXIRI plus bevacizumab and reintroduction after progression versus mFOLFOX6 plus bevacizumab followed by FOLFIRI plus bevacizumab in the treatment of patients with metastatic colorectal cancer (TRIBE2): a multicentre, open-label, phase 3, randomised, controlled trial

Author

Falcone, Alfredo, Lonardi, Sara, De Braud, Filippo Guglielmo Maria, Bordonaro, Roberto, Maiello, Evaristo, Tamburini, Emiliano, Santini, Daniele, Frassineti, Giovanni Luca, Gamucci, Teresa, Aprile, Giuseppe, Zaniboni, Alberto, Granetto, Cristina, Buonadonna, Angela, Di Costanzo, Francesco, Tomasello, Gianluca, Gianni, Luca, Di Donato, Samantha, Carlomagno, Chiara, Clavarezza, Matteo, Racca, Patrizia, Mambrini, Andrea, Roselli, Mario, Allegrini, Giacomo, Sobrero, Alberto, Aglietta, Massimo, Corgna, Enrichetta, Cortesi, Enrico, Corsi, Domenico Cristiano, Ballestrero, Alberto, Bonetti, Andrea, Di Clemente, Francesco, Ruggeri, Enzo, Ciardiello, Fortunato, Benasso, Marco, Vitello, Stefano, Cinieri, Saverio, Mosconi, Stefania, Silvestris, Nicola, Frassoldati, Antonio, Cupini, Samantha, Bertolini, Alessandro, Tortora, Giampaolo, Bengala, Carmelo, Ferrari, Daris, Ardizzoia, Antonia, Milandri, Carlo, Chiara, Silvana, Romano, Gianpiero, Miraglia, Stefania, Scaltriti, Laura, Pucci, Francesca, Blasi, Livio, Brugnatelli, Silvia, Fioretto, Luisa, Ribecco, Angela Stefania, Longarini, Raffaella, Frisinghelli, Michela, Banzi, Maria, Cremolini, Chiara, Antoniotti, Carlotta, Rossini, Daniele, Loupakis, Fotios, Pietrantonio, Filippo, Latiano, Tiziana Pia, Passardi, Alessandro, Marmorino, Federica, Grande, Roberta, Murgioni, Sabina, Moretto, Roberto, Corallo, Salvatore, Cordio, Stefano, Antonuzzo, Lorenzo, Masi, Gianluca, Ronzoni, Monica, Ritorto, Giuliana, Cupini, Samanta, Mammoliti, Serafina, Fenocchio, Elisabetta, Zagonel, Vittorina, Fontanini, Gabriella, Ugolini, Clara, and Boni, Luca

Published
2020
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11. Treatments after progression to first-line FOLFOXIRI and bevacizumab in metastatic colorectal cancer: a pooled analysis of TRIBE and TRIBE2 studies by GONO

Author

Rossini, Daniele, Lonardi, Sara, Antoniotti, Carlotta, Santini, Daniele, Tomasello, Gianluca, Ermacora, Paola, Germani, Marco Maria, Bergamo, Francesca, Ricci, Vincenzo, Caponnetto, Salvatore, Moretto, Roberto, Zaniboni, Alberto, Pietrantonio, Filippo, Buonadonna, Angela, Ritorto, Giuliana, Masi, Gianluca, Latiano, Tiziana Pia, Rapisardi, Stefania, Falcone, Alfredo, and Cremolini, Chiara

Published
2021
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13. DPYD*6 plays an important role in fluoropyrimidine toxicity in addition to DPYD*2A and c.2846A>T: a comprehensive analysis in 1254 patients

Author

Del Re, Marzia, Cinieri, Saverio, Michelucci, Angela, Salvadori, Stefano, Loupakis, Fotios, Schirripa, Marta, Cremolini, Chiara, Crucitta, Stefania, Barbara, Cecilia, Di Leo, Angelo, Latiano, Tiziana Pia, Pietrantonio, Filippo, Di Donato, Samantha, Simi, Paolo, Passardi, Alessandro, De Braud, Filippo, Altavilla, Giuseppe, Zamagni, Claudio, Bordonaro, Roberto, Butera, Alfredo, Maiello, Evaristo, Pinto, Carmine, Falcone, Alfredo, Mazzotti, Valentina, Morganti, Riccardo, and Danesi, Romano

Published
2019
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14. Stemness underpinning all steps of human colorectal cancer defines the core of effective therapeutic strategies

Author

Visioli, Alberto, Giani, Fabrizio, Trivieri, Nadia, Pracella, Riccardo, Miccinilli, Elide, Cariglia, Maria Grazia, Palumbo, Orazio, Arleo, Andrea, Dezi, Fabio, Copetti, Massimiliano, Cajola, Laura, Restelli, Silvia, Papa, Valerio, Sciuto, Antonio, Latiano, Tiziana Pia, Carella, Massimo, Amadori, Dino, Gallerani, Giulia, Ricci, Riccardo, Alfieri, Sergio, Pesole, Graziano, Vescovi, Angelo L., and Binda, Elena

Published
2019
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15. Italian survey on cetuximab-based therapy of elderly patients with metastatic colorectal cancer

Author

Rosati, Gerardo, Addeo, Raffaele, Aprile, Giuseppe, Avallone, Antonio, Bilancia, Domenico, Brugnatelli, Silvia, Buccafusca, Gabriella, Carlomagno, Chiara, Cordio, Stefano, Delfanti, Sara, Dell’Aquila, Emanuela, Di Bisceglie, Maurizio, Di Donato, Samantha, Di Stasi, Antonio, Germano, Domenico, Giuliani, Francesco, Granetto, Cristina, Latiano, Tiziana Pia, Leo, Silvana, Tralongo, Paolo, Stroppolo, Maria Elena, Venturini, Filippo, and Bianco, Salvatore

Published
2019
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16. BRAFV600E mutation impinges on gut microbial markers defining novel biomarkers for serrated colorectal cancer effective therapies

Author

Trivieri, Nadia, Pracella, Riccardo, Cariglia, Maria Grazia, Panebianco, Concetta, Parrella, Paola, Visioli, Alberto, Giani, Fabrizio, Soriano, Amata Amy, Barile, Chiara, Canistro, Giuseppe, Latiano, Tiziana Pia, Dimitri, Lucia, Bazzocchi, Francesca, Cassano, Dario, Vescovi, Angelo L., Pazienza, Valerio, and Binda, Elena

Published
2020
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17. Clinical outcome of patients with chemorefractory metastatic colorectal cancer treated with trifluridine/tipiracil (TAS-102): a single Italian institution compassionate use programme

Author

Sforza, Vincenzo, Martinelli, Erika, Cardone, Claudia, Martini, Giulia, Napolitano, Stefania, Vitiello, Pietro Paolo, Vitale, Pasquale, Zanaletti, Nicoletta, Reginelli, Alfonso, Bisceglie, Maurizio Di, Latiano, Tiziana Pia, Bochicchio, Anna Maria, Cecere, Fabiana, Selvaggi, Francesco, Ciardiello, Fortunato, and Troiani, Teresa

Published
2017
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18. Clinical outcome and molecular characterisation of chemorefractory metastatic colorectal cancer patients with long-term efficacy of regorafenib treatment

Author

Martinelli, Erika, Sforza, Vincenzo, Cardone, Claudia, Capasso, Anna, Nappi, Anna, Martini, Giulia, Napolitano, Stefania, Rachiglio, Anna Maria, Normanno, Nicola, Cappabianca, Salvatore, Reginelli, Alfonso, Bisceglie, Maurizio Di, Latiano, Tiziana Pia, Maiello, Evaristo, Orditura, Michele, De Vita, Fernando, Morgillo, Floriana, Ciardiello, Fortunato, and Troiani, Teresa

Published
2017
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19. Supplementary Table 1 from EPHA2 Is a Predictive Biomarker of Resistance and a Potential Therapeutic Target for Improving Antiepidermal Growth Factor Receptor Therapy in Colorectal Cancer

Author

Martini, Giulia, primary, Cardone, Claudia, primary, Vitiello, Pietro Paolo, primary, Belli, Valentina, primary, Napolitano, Stefania, primary, Troiani, Teresa, primary, Ciardiello, Davide, primary, Della Corte, Carminia Maria, primary, Morgillo, Floriana, primary, Matrone, Nunzia, primary, Sforza, Vincenzo, primary, Papaccio, Gianpaolo, primary, Desiderio, Vincenzo, primary, Paul, Mariel C., primary, Moreno-Viedma, Veronica, primary, Normanno, Nicola, primary, Rachiglio, Anna Maria, primary, Tirino, Virginia, primary, Maiello, Evaristo, primary, Latiano, Tiziana Pia, primary, Rizzi, Daniele, primary, Signoriello, Giuseppe, primary, Sibilia, Maria, primary, Ciardiello, Fortunato, primary, and Martinelli, Erika, primary

Published
2023
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20. Supplementary Table 2 from EPHA2 Is a Predictive Biomarker of Resistance and a Potential Therapeutic Target for Improving Antiepidermal Growth Factor Receptor Therapy in Colorectal Cancer

Author

Martini, Giulia, primary, Cardone, Claudia, primary, Vitiello, Pietro Paolo, primary, Belli, Valentina, primary, Napolitano, Stefania, primary, Troiani, Teresa, primary, Ciardiello, Davide, primary, Della Corte, Carminia Maria, primary, Morgillo, Floriana, primary, Matrone, Nunzia, primary, Sforza, Vincenzo, primary, Papaccio, Gianpaolo, primary, Desiderio, Vincenzo, primary, Paul, Mariel C., primary, Moreno-Viedma, Veronica, primary, Normanno, Nicola, primary, Rachiglio, Anna Maria, primary, Tirino, Virginia, primary, Maiello, Evaristo, primary, Latiano, Tiziana Pia, primary, Rizzi, Daniele, primary, Signoriello, Giuseppe, primary, Sibilia, Maria, primary, Ciardiello, Fortunato, primary, and Martinelli, Erika, primary

Published
2023
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21. Data from EPHA2 Is a Predictive Biomarker of Resistance and a Potential Therapeutic Target for Improving Antiepidermal Growth Factor Receptor Therapy in Colorectal Cancer

Author

Martini, Giulia, primary, Cardone, Claudia, primary, Vitiello, Pietro Paolo, primary, Belli, Valentina, primary, Napolitano, Stefania, primary, Troiani, Teresa, primary, Ciardiello, Davide, primary, Della Corte, Carminia Maria, primary, Morgillo, Floriana, primary, Matrone, Nunzia, primary, Sforza, Vincenzo, primary, Papaccio, Gianpaolo, primary, Desiderio, Vincenzo, primary, Paul, Mariel C., primary, Moreno-Viedma, Veronica, primary, Normanno, Nicola, primary, Rachiglio, Anna Maria, primary, Tirino, Virginia, primary, Maiello, Evaristo, primary, Latiano, Tiziana Pia, primary, Rizzi, Daniele, primary, Signoriello, Giuseppe, primary, Sibilia, Maria, primary, Ciardiello, Fortunato, primary, and Martinelli, Erika, primary

Published
2023
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22. Supplementary Figure 2 from EPHA2 Is a Predictive Biomarker of Resistance and a Potential Therapeutic Target for Improving Antiepidermal Growth Factor Receptor Therapy in Colorectal Cancer

Author

Martini, Giulia, primary, Cardone, Claudia, primary, Vitiello, Pietro Paolo, primary, Belli, Valentina, primary, Napolitano, Stefania, primary, Troiani, Teresa, primary, Ciardiello, Davide, primary, Della Corte, Carminia Maria, primary, Morgillo, Floriana, primary, Matrone, Nunzia, primary, Sforza, Vincenzo, primary, Papaccio, Gianpaolo, primary, Desiderio, Vincenzo, primary, Paul, Mariel C., primary, Moreno-Viedma, Veronica, primary, Normanno, Nicola, primary, Rachiglio, Anna Maria, primary, Tirino, Virginia, primary, Maiello, Evaristo, primary, Latiano, Tiziana Pia, primary, Rizzi, Daniele, primary, Signoriello, Giuseppe, primary, Sibilia, Maria, primary, Ciardiello, Fortunato, primary, and Martinelli, Erika, primary

Published
2023
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23. Supplementary Materials and Methods from EPHA2 Is a Predictive Biomarker of Resistance and a Potential Therapeutic Target for Improving Antiepidermal Growth Factor Receptor Therapy in Colorectal Cancer

Author

Martini, Giulia, primary, Cardone, Claudia, primary, Vitiello, Pietro Paolo, primary, Belli, Valentina, primary, Napolitano, Stefania, primary, Troiani, Teresa, primary, Ciardiello, Davide, primary, Della Corte, Carminia Maria, primary, Morgillo, Floriana, primary, Matrone, Nunzia, primary, Sforza, Vincenzo, primary, Papaccio, Gianpaolo, primary, Desiderio, Vincenzo, primary, Paul, Mariel C., primary, Moreno-Viedma, Veronica, primary, Normanno, Nicola, primary, Rachiglio, Anna Maria, primary, Tirino, Virginia, primary, Maiello, Evaristo, primary, Latiano, Tiziana Pia, primary, Rizzi, Daniele, primary, Signoriello, Giuseppe, primary, Sibilia, Maria, primary, Ciardiello, Fortunato, primary, and Martinelli, Erika, primary

Published
2023
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24. Supplementary Table 3 from EPHA2 Is a Predictive Biomarker of Resistance and a Potential Therapeutic Target for Improving Antiepidermal Growth Factor Receptor Therapy in Colorectal Cancer

Author

Martini, Giulia, primary, Cardone, Claudia, primary, Vitiello, Pietro Paolo, primary, Belli, Valentina, primary, Napolitano, Stefania, primary, Troiani, Teresa, primary, Ciardiello, Davide, primary, Della Corte, Carminia Maria, primary, Morgillo, Floriana, primary, Matrone, Nunzia, primary, Sforza, Vincenzo, primary, Papaccio, Gianpaolo, primary, Desiderio, Vincenzo, primary, Paul, Mariel C., primary, Moreno-Viedma, Veronica, primary, Normanno, Nicola, primary, Rachiglio, Anna Maria, primary, Tirino, Virginia, primary, Maiello, Evaristo, primary, Latiano, Tiziana Pia, primary, Rizzi, Daniele, primary, Signoriello, Giuseppe, primary, Sibilia, Maria, primary, Ciardiello, Fortunato, primary, and Martinelli, Erika, primary

Published
2023
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25. Supplementary Figure 1 from EPHA2 Is a Predictive Biomarker of Resistance and a Potential Therapeutic Target for Improving Antiepidermal Growth Factor Receptor Therapy in Colorectal Cancer

Author

Martini, Giulia, primary, Cardone, Claudia, primary, Vitiello, Pietro Paolo, primary, Belli, Valentina, primary, Napolitano, Stefania, primary, Troiani, Teresa, primary, Ciardiello, Davide, primary, Della Corte, Carminia Maria, primary, Morgillo, Floriana, primary, Matrone, Nunzia, primary, Sforza, Vincenzo, primary, Papaccio, Gianpaolo, primary, Desiderio, Vincenzo, primary, Paul, Mariel C., primary, Moreno-Viedma, Veronica, primary, Normanno, Nicola, primary, Rachiglio, Anna Maria, primary, Tirino, Virginia, primary, Maiello, Evaristo, primary, Latiano, Tiziana Pia, primary, Rizzi, Daniele, primary, Signoriello, Giuseppe, primary, Sibilia, Maria, primary, Ciardiello, Fortunato, primary, and Martinelli, Erika, primary

Published
2023
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26. Efficacy and safety of a biomarker-driven cetuximab-based treatment regimen over 3 treatment lines in mCRC patients with RAS/BRAF wild type tumors at start of first line: The CAPRI 2 GOIM trial

Author

Martini, Giulia, primary, Ciardiello, Davide, additional, Napolitano, Stefania, additional, Martinelli, Erika, additional, Troiani, Teresa, additional, Latiano, Tiziana Pia, additional, Avallone, Antonio, additional, Normanno, Nicola, additional, Di Maio, Massimo, additional, Maiello, Evaristo, additional, and Ciardiello, Fortunato, additional

Published
2023
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28. Correction: Ciardiello et al. Biomarker-Guided Anti-EGFR Rechallenge Therapy in Metastatic Colorectal Cancer. Cancers 2021, 13, 1941

Author

Ciardiello, Davide, primary, Martini, Giulia, additional, Famiglietti, Vincenzo, additional, Napolitano, Stefania, additional, De Falco, Vincenzo, additional, Troiani, Teresa, additional, Latiano, Tiziana Pia, additional, Ros, Javier, additional, Elez Fernandez, Elena, additional, Vitiello, Pietro Paolo, additional, Maiello, Evaristo, additional, Ciardiello, Fortunato, additional, and Martinelli, Erika, additional

Published
2022
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29. Butyrate, a postbiotic of intestinal bacteria, affects pancreatic cancer and gemcitabine response in in vitro and in vivo models

Author

Panebianco, Concetta, primary, Villani, Annacandida, additional, Pisati, Federica, additional, Orsenigo, Fabrizio, additional, Ulaszewska, Marynka, additional, Latiano, Tiziana Pia, additional, Potenza, Adele, additional, Andolfo, Annapaola, additional, Terracciano, Fulvia, additional, Tripodo, Claudio, additional, Perri, Francesco, additional, and Pazienza, Valerio, additional

Published
2022
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30. Mucosal Microbiota from Colorectal Cancer, Adenoma and Normal Epithelium Reveals the Imprint of Fusobacterium nucleatum in Cancerogenesis.

Author

Palmieri, Orazio, Castellana, Stefano, Latiano, Anna, Latiano, Tiziana, Gentile, Annamaria, Panza, Anna, Nardella, Marianna, Ciardiello, Davide, Latiano, Tiziana Pia, Corritore, Giuseppe, Mazza, Tommaso, Perri, Francesco, and Biscaglia, Giuseppe

Subjects
ADENOMATOUS polyps, COLORECTAL cancer, FUSOBACTERIUM, EPITHELIUM, ADENOMA, GUT microbiome
Abstract

An increasing amount of evidence suggests the emerging role of the gut microbiota in the development of colorectal cancer (CRC). This study aimed to elucidate the architecture of microbial communities within normal and neoplastic colonic mucosa. Methods: Microbiota were analyzed by NGS and by an ensemble of metagenomics analysis tools in a total of 69 tissues from 9 patients with synchronous colorectal neoplasia and adenomas (27 specimens: 9 from normal tissues, 9 adenomas, and 9 tumours), 16 patients with only colonic adenomas (32 specimens: 16 from normal tissues and 16 adenomas), and from healthy subjects (10 specimens of normal mucosa). Results: Weak differences were observed in alpha and beta metrics among the synchronous tissues from CRC and controls. Through pairwise differential abundance analyses of sample groups, an increasing trend of Rikenellaceae, Pseudomonas and Fusobacterium, and decreasing trends of Staphylococcus, Actinobacillus and Gemmiger were observed in CRC, while Staphylococcus and Bifidobacterium were decreased in patients with only adenomas. At RT-qPCR analysis, Fusobacterium nucleatum was significantly enriched in all the tissues of subjects with synchronous colorectal neoplasia. Conclusion: Our findings provide a comprehensive view of the human mucosa-associated gut microbiota, emphasizing global microbial diversity mostly in synchronous lesions and proving the constant presence of Fusobacterium nucleatum, with its ability to drive carcinogenesis. [ABSTRACT FROM AUTHOR]

Published
2023
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32. Immunotherapy in advanced anal cancer: Is the beginning of a new era?

Author

Ciardiello, Davide, primary, Guerrera, Luigi Pio, additional, Maiorano, Brigida Anna, additional, Parente, Paola, additional, Latiano, Tiziana Pia, additional, Di Maio, Massimo, additional, Ciardiello, Fortunato, additional, Troiani, Teresa, additional, Martinelli, Erika, additional, and Maiello, Evaristo, additional

Published
2022
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33. Bevacizumab-induced hypertension as a predictor of clinical outcome in metastatic colorectal cancer: An individual patient data-based pooled analysis of two randomized studies and a systematic review of the literature

Author

Lombardi, Pasquale, primary, Rossini, Daniele, additional, Crespi, Veronica, additional, Germani, Marco Maria, additional, Bergamo, Francesca, additional, Pietrantonio, Filippo, additional, Santini, Daniele, additional, Allegrini, Giacomo, additional, Daniel, Francesca, additional, Pagani, Filippo, additional, Antoniotti, Carlotta, additional, Zaniboni, Alberto, additional, Conca, Veronica, additional, Latiano, Tiziana Pia, additional, Boccaccino, Alessandra, additional, Passardi, Alessandro, additional, Tamburini, Emiliano, additional, Masi, Gianluca, additional, Di Maio, Massimo, additional, and Cremolini, Chiara, additional

Published
2022
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34. Immunotherapy for Biliary Tract Cancer in the Era of Precision Medicine: Current Knowledge and Future Perspectives

Author

Ciardiello, Davide, primary, Maiorano, Brigida Anna, additional, Parente, Paola, additional, Rodriquenz, Maria Grazia, additional, Latiano, Tiziana Pia, additional, Chiarazzo, Cinzia, additional, Pazienza, Valerio, additional, Guerrera, Luigi Pio, additional, Amoruso, Brunella, additional, Normanno, Nicola, additional, Martini, Giulia, additional, Ciardiello, Fortunato, additional, Martinelli, Erika, additional, and Maiello, Evaristo, additional

Published
2022
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35. Tuning gut microbiota through a probiotic blend in gemcitabine‐treated pancreatic cancer xenografted mice

Author

Panebianco, Concetta, primary, Pisati, Federica, additional, Ulaszewska, Maria, additional, Andolfo, Annapaola, additional, Villani, Annacandida, additional, Federici, Federica, additional, Laura, Manna, additional, Rizzi, Eleonora, additional, Potenza, Adele, additional, Latiano, Tiziana Pia, additional, Perri, Francesco, additional, Tripodo, Claudio, additional, and Pazienza, Valerio, additional

Published
2021
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36. Italian results of the PRECONNECT study: safety and efficacy of trifluridine/tipiracil in metastatic colorectal cancer

Author

Zaniboni, Alberto, primary, Barone, Carlo Antonio, additional, Banzi, Maria Chiara, additional, Bergamo, Francesca, additional, Blasi, Livio, additional, Bordonaro, Roberto, additional, Bartolomeo, Maria Di, additional, Costanzo, Francesco Di, additional, Frassineti, Giovanni Luca, additional, Garufi, Carlo, additional, Giuliani, Francesco, additional, Latiano, Tiziana Pia, additional, Martinelli, Erika, additional, Personeni, Nicola, additional, Racca, Patrizia, additional, Tamburini, Emiliano, additional, Tonini, Giuseppe, additional, Besse, Marie Georges, additional, Spione, Mario, additional, and Falcone, Alfredo, additional

Published
2021
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38. Activity and Safety of NAB-FOLFIRI and NAB-FOLFOX as First-Line Treatment for metastatic Pancreatic Cancer (NabucCO Study)

Author

Giommoni, Elisa, primary, Maiello, Evaristo, additional, Vaccaro, Vanja, additional, Rondini, Ermanno, additional, Vivaldi, Caterina, additional, Tortora, Giampaolo, additional, Toppo, Laura, additional, Giordano, Guido, additional, Latiano, Tiziana Pia, additional, Lamperini, Cinzia, additional, Pillozzi, Serena, additional, Boni, Luca, additional, Antonuzzo, Lorenzo, additional, and Di Costanzo, Francesco, additional

Published
2021
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40. Additional file 1 of BRAFV600E mutation impinges on gut microbial markers defining novel biomarkers for serrated colorectal cancer effective therapies

Author

Trivieri, Nadia, Pracella, Riccardo, Cariglia, Maria Grazia, Panebianco, Concetta, Parrella, Paola, Visioli, Alberto, Giani, Fabrizio, Soriano, Amata Amy, Barile, Chiara, Canistro, Giuseppe, Latiano, Tiziana Pia, Dimitri, Lucia, Bazzocchi, Francesca, Cassano, Dario, Vescovi, Angelo L., Pazienza, Valerio, and Binda, Elena

Abstract

Additional file 1:. Supplementary methods

Published
2020
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42. High RAD51 mRNA expression characterize estrogen receptor-positive/progesteron receptor-negative breast cancer and is associated with patientʼs outcome

Author

Barbano, Raffaela, Copetti, Massimiliano, Perrone, Giuseppe, Pazienza, Valerio, Muscarella, Lucia Anna, Balsamo, Teresa, Storlazzi, Clelia Tiziana, Ripoli, Maria, Rinaldi, Monica, Valori, Vanna Maria, Latiano, Tiziana Pia, Maiello, Evaristo, Stanziale, Pietro, Carella, Massimo, Mangia, Alessandra, Pellegrini, Fabio, Bisceglia, Michele, Muda, Andrea Onetti, Altomare, Vittorio, Murgo, Roberto, Fazio, Vito Michele, and Parrella, Paola

Published
2011
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43. Treatments after progression to first-line FOLFOXIRI and bevacizumab in metastatic colorectal cancer: a pooled analysis of TRIBE and TRIBE2 studies by GONO

Author

Rossini, Daniele, primary, Lonardi, Sara, additional, Antoniotti, Carlotta, additional, Santini, Daniele, additional, Tomasello, Gianluca, additional, Ermacora, Paola, additional, Germani, Marco Maria, additional, Bergamo, Francesca, additional, Ricci, Vincenzo, additional, Caponnetto, Salvatore, additional, Moretto, Roberto, additional, Zaniboni, Alberto, additional, Pietrantonio, Filippo, additional, Buonadonna, Angela, additional, Ritorto, Giuliana, additional, Masi, Gianluca, additional, Latiano, Tiziana Pia, additional, Rapisardi, Stefania, additional, Falcone, Alfredo, additional, and Cremolini, Chiara, additional

Published
2020
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44. Bevacizumab in Combination With Either FOLFOX-4 or XELOX-2 in First-line Treatment of Patients With Metastatic Colorectal Cancer: A Multicenter Randomized Phase II Trial of the Gruppo Oncologico dell’Italia Meridionale (GOIM 2802)

Author

Maiello, Evaristo, primary, Di Maggio, Gabriele, additional, Cordio, Stefano, additional, Cinieri, Saverio, additional, Giuliani, Francesco, additional, Pisconti, Salvatore, additional, Rinaldi, Antonio, additional, Febbraro, Antonio, additional, Latiano, Tiziana Pia, additional, Aieta, Michele, additional, Rossi, Antonio, additional, Rizzi, Daniele, additional, Di Maio, Massimo, additional, Colucci, Giuseppe, additional, and Bordonaro, Roberto, additional

Published
2020
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45. Upfront FOLFOXIRI plus bevacizumab and reintroduction after progression versus mFOLFOX6 plus bevacizumab followed by FOLFIRI plus bevacizumab in the treatment of patients with metastatic colorectal cancer (TRIBE2): a multicentre, open-label, phase 3, randomised, controlled trial

Author

Cremolini, Chiara, primary, Antoniotti, Carlotta, additional, Rossini, Daniele, additional, Lonardi, Sara, additional, Loupakis, Fotios, additional, Pietrantonio, Filippo, additional, Bordonaro, Roberto, additional, Latiano, Tiziana Pia, additional, Tamburini, Emiliano, additional, Santini, Daniele, additional, Passardi, Alessandro, additional, Marmorino, Federica, additional, Grande, Roberta, additional, Aprile, Giuseppe, additional, Zaniboni, Alberto, additional, Murgioni, Sabina, additional, Granetto, Cristina, additional, Buonadonna, Angela, additional, Moretto, Roberto, additional, Corallo, Salvatore, additional, Cordio, Stefano, additional, Antonuzzo, Lorenzo, additional, Tomasello, Gianluca, additional, Masi, Gianluca, additional, Ronzoni, Monica, additional, Di Donato, Samantha, additional, Carlomagno, Chiara, additional, Clavarezza, Matteo, additional, Ritorto, Giuliana, additional, Mambrini, Andrea, additional, Roselli, Mario, additional, Cupini, Samanta, additional, Mammoliti, Serafina, additional, Fenocchio, Elisabetta, additional, Corgna, Enrichetta, additional, Zagonel, Vittorina, additional, Fontanini, Gabriella, additional, Ugolini, Clara, additional, Boni, Luca, additional, Falcone, Alfredo, additional, De Braud, Filippo Guglielmo Maria, additional, Maiello, Evaristo, additional, Frassineti, Giovanni Luca, additional, Gamucci, Teresa, additional, Di Costanzo, Francesco, additional, Gianni, Luca, additional, Racca, Patrizia, additional, Allegrini, Giacomo, additional, Sobrero, Alberto, additional, Aglietta, Massimo, additional, Cortesi, Enrico, additional, Corsi, Domenico Cristiano, additional, Ballestrero, Alberto, additional, Bonetti, Andrea, additional, Di Clemente, Francesco, additional, Ruggeri, Enzo, additional, Ciardiello, Fortunato, additional, Benasso, Marco, additional, Vitello, Stefano, additional, Cinieri, Saverio, additional, Mosconi, Stefania, additional, Silvestris, Nicola, additional, Frassoldati, Antonio, additional, Cupini, Samantha, additional, Bertolini, Alessandro, additional, Tortora, Giampaolo, additional, Bengala, Carmelo, additional, Ferrari, Daris, additional, Ardizzoia, Antonia, additional, Milandri, Carlo, additional, Chiara, Silvana, additional, Romano, Gianpiero, additional, Miraglia, Stefania, additional, Scaltriti, Laura, additional, Pucci, Francesca, additional, Blasi, Livio, additional, Brugnatelli, Silvia, additional, Fioretto, Luisa, additional, Ribecco, Angela Stefania, additional, Longarini, Raffaella, additional, Frisinghelli, Michela, additional, and Banzi, Maria, additional

Published
2020
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47. Crosstalk between the Tumor Microenvironment and Immune System in Pancreatic Ductal Adenocarcinoma: Potential Targets for New Therapeutic Approaches

Author

Parente, Paola, Parcesepe, Pietro, Covelli, Claudia, Olivieri, Nunzio, Remo, Andrea, Pancione, Massimo, Latiano, Tiziana Pia, Graziano, Paolo, Maiello, Evaristo, and Giordano, Guido

Subjects
Article Subject
Abstract

Pancreatic ductal adenocarcinoma is a lethal disease for which radical surgery and chemotherapy represent the only curative options for a small proportion of patients. Recently, FOLFIRINOX and nab-paclitaxel plus gemcitabine have improved the survival of metastatic patients but prognosis remains poor. A pancreatic tumor microenvironment is a dynamic milieu of cellular and acellular elements, and it represents one of the major limitations to chemotherapy efficacy. The continued crosstalk between cancer cells and the surrounding microenvironment causes immunosuppression within pancreatic immune infiltrate increasing tumor aggressiveness. Several potential targets have been identified among tumor microenvironment components, and different therapeutic approaches are under investigation. In this article, we provide a qualitative literature review about the crosstalk between the tumor microenvironment components and immune system in pancreatic cancer. Finally, we discuss potential therapeutic strategies targeting the tumor microenvironment and we show the ongoing trials.

Published
2018
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48. Clinical impact of neutropenia and febrile neutropenia in mCRC pts treated with FOLFOXIRI/bevacizumab (bev): A pooled analysis of TRIBE and TRIBE2 studies.

Author

Rossini, Daniele, primary, Sbrana, Andrea, additional, Bergamo, Francesca, additional, Manai, Chiara, additional, Santini, Daniele, additional, Ghidini, Michele, additional, Antoniotti, Carlotta, additional, Moretto, Roberto, additional, Marmorino, Federica, additional, Urbano, Federica, additional, Ronzoni, Monica, additional, Noventa, Silvia, additional, Randon, Giovanni, additional, Carlomagno, Chiara, additional, Latiano, Tiziana Pia, additional, Cordio, Stefano Sergio, additional, Granetto, Cristina, additional, Cremolini, Chiara, additional, Falcone, Alfredo, additional, and Antonuzzo, Andrea, additional

Published
2019
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49. EPHA2 Is a Predictive Biomarker of Resistance and a Potential Therapeutic Target for Improving Antiepidermal Growth Factor Receptor Therapy in Colorectal Cancer

Author

Martini, Giulia, primary, Cardone, Claudia, additional, Vitiello, Pietro Paolo, additional, Belli, Valentina, additional, Napolitano, Stefania, additional, Troiani, Teresa, additional, Ciardiello, Davide, additional, Della Corte, Carminia Maria, additional, Morgillo, Floriana, additional, Matrone, Nunzia, additional, Sforza, Vincenzo, additional, Papaccio, Gianpaolo, additional, Desiderio, Vincenzo, additional, Paul, Mariel C., additional, Moreno-Viedma, Veronica, additional, Normanno, Nicola, additional, Rachiglio, Anna Maria, additional, Tirino, Virginia, additional, Maiello, Evaristo, additional, Latiano, Tiziana Pia, additional, Rizzi, Daniele, additional, Signoriello, Giuseppe, additional, Sibilia, Maria, additional, Ciardiello, Fortunato, additional, and Martinelli, Erika, additional

Published
2019
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50. Colonic Ewing Sarcoma/PNET associated with liver metastases: A systematic review and case report

Author

Parcesepe, Pietro, primary, Giordano, Guido, additional, Zanella, Caterina, additional, Giuliani, Jacopo, additional, Greco, Filippo, additional, Bonetti, Andrea, additional, Pancione, Massimo, additional, Manfrin, Erminia, additional, Molinari, Enrico, additional, Latiano, Tiziana Pia, additional, D’Andrea, Mario Rosario, additional, Fassan, Matteo, additional, Olivieri, Nunzio, additional, and Remo, Andrea, additional

Published
2019
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