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1. Historical dataset details the distribution, extent and form of lost Ostrea edulis reef ecosystems

Author

Thurstan, Ruth H., McCormick, Hannah, Preston, Joanne, Ashton, Elizabeth C., Bennema, Floris P., Bratoš Cetinić, Ana, Brown, Janet H., Cameron, Tom C., da Costa, Fiz, Donnan, David W., Ewers, Christine, Fortibuoni, Tomaso, Galimany, Eve, Giovanardi, Otello, Grancher, Romain, Grech, Daniele, Hayden-Hughes, Maria, Helmer, Luke, Jensen, K. Thomas, Juanes, José A., Latchford, Janie, Moore, Alec B. M., Moutopoulos, Dimitrios K., Nielsen, Pernille, von Nordheim, Henning, Ondiviela, Bárbara, Peter, Corina, Pogoda, Bernadette, Poulsen, Bo, Pouvreau, Stéphane, Scherer, Cordula, Smaal, Aad C., Smyth, David, Strand, Åsa, Theodorou, John A., and zu Ermgassen, Philine S. E.

Published
2024
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2. Bendamustine is a safe and effective lymphodepletion agent for axicabtagene ciloleucel in patients with refractory or relapsed large B-cell lymphoma

Author

Crystal Mackall, Holden T Maecker, Lekha Mikkilineni, Melody Smith, Saurabh Dahiya, Bita Sahaf, David Miklos, Sally Arai, Surbhi Sidana, Wen-Kai Weng, Dasom Lee, Anmol Goyal, Sushma Bharadwaj, Eric Lau, Mark P Hamilton, Hrishi Srinagesh, Alexandria Jensen, Jayasindhu Mallampet, Sarah Elkordy, Shriya Syal, Sunita Patil, Theresa Latchford, Laura J Johnston, Robert Lowsky, Robert Negrin, Andrew R Rezvani, Judith Shizuru, Everett H Meyer, Parveen Shiraz, Lori Muffly, and Matthew J Frank

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Background Fludarabine in combination with cyclophosphamide (FC) is the standard lymphodepletion regimen for CAR T-cell therapy (CAR T). A national fludarabine shortage in 2022 necessitated the exploration of alternative regimens with many centers employing single-agent bendamustine as lymphodepletion despite a lack of clinical safety and efficacy data. To fill this gap in the literature, we evaluated the safety, efficacy, and expansion kinetics of bendamustine as lymphodepletion prior to axicabtagene ciloleucel (axi-cel) therapy.Methods 84 consecutive patients with relapsed or refractory large B-cell lymphoma treated with axi-cel and managed with a uniform toxicity management plan at Stanford University were studied. 27 patients received alternative lymphodepletion with bendamustine while 57 received FC.Results Best complete response rates were similar (73.7% for FC and 74% for bendamustine, p=0.28) and there was no significant difference in 12-month progression-free survival or overall survival estimates (p=0.17 and p=0.62, respectively). The frequency of high-grade cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome was similar in both the cohorts. Bendamustine cohort experienced lower proportions of hematological toxicities and antibiotic use for neutropenic fever. Immune reconstitution, as measured by quantitative assessment of cellular immunity, was better in bendamustine cohort as compared with FC cohort. CAR T expansion as measured by peak expansion and area under the curve for expansion was comparable between cohorts.Conclusions Bendamustine is a safe and effective alternative lymphodepletion conditioning for axi-cel with lower early hematological toxicity and favorable immune reconstitution.

Published
2024
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3. Large-scale application of ClinGen-InSiGHT APC-specific ACMG/AMP variant classification criteria leads to substantial reduction in VUS

Author

Yin, Xiaoyu, Richardson, Marcy, Laner, Andreas, Shi, Xuemei, Ognedal, Elisabet, Vasta, Valeria, Hansen, Thomas v.O., Pineda, Marta, Ritter, Deborah, de Dunnen, Johan, Hassanin, Emadeldin, Lin, Wencong Lyman, Borras, Ester, Krahn, Karl, Nordling, Margareta, Martins, Alexandra, Mahmood, Khalid, Nadeau, Emily, Beshay, Victoria, Tops, Carli, Genuardi, Maurizio, Pesaran, Tina, Frayling, Ian M., Capellá, Gabriel, Latchford, Andrew, Tavtigian, Sean V., Maj, Carlo, Plon, Sharon E., Greenblatt, Marc S., Macrae, Finlay A., Spier, Isabel, and Aretz, Stefan

Published
2024
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4. Development of Desmoid Tumors After Ileorectal Anastomosis Versus Ileal Pouch-Anal Anastomosis in Familial Adenomatous Polyposis

Author

Aelvoet, Arthur S., Pellisé, Maria, Miedema, Thymen N., Daca-Alvarez, Maria, Bastiaansen, Barbara A.J., van Leerdam, Monique E., Jover, Rodrigo, Balaguer, Francesc, Kaminski, Michal F., Buttitta, Francesco, Ricciardiello, Luigi, Jespersen, Niels, Karstensen, John G., Bossuyt, Patrick M.M., Latchford, Andrew, Hompes, Roel, and Dekker, Evelien

Published
2024
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6. Hereditary gastrointestinal polyposis syndromes Rare Disease Collaborative Network consensus statement agreed at the RDCN meeting Birmingham 17th February 2022

Author

Clark, Susan, Cuthill, Vicky, Hawkins, Jackie, Hyer, Warren, Latchford, Andy, Sinha, Ashish, Din, Farhat, Beggs, Andrew, Desai, Anant, Morton, Dion, Hitchen, Debbie, Hill, James, Lalloo, Fiona, Newton, Katy, Pugh, Sarah, Dolwani, Sunil, Hargest, Rachel, Horwood, James, Ramaraj, Raji, Rogers, Mark, Collins, Paul, McNichol, Frances, Beck, Nicholas, Side, Lucy, and McDermott, Frank

Published
2023
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9. Outcomes following duodenectomy in patients with familial adenomatous polyposis

Author

Arthur S. Aelvoet, Isabel Martin, James Cockburn, Cherryl Cabalit, Victoria Cuthill, Duncan Spalding, Olivier Busch, Barbara A.J. Bastiaansen, Susan K. Clark, Evelien Dekker, and Andrew Latchford

Subjects
Familial adenomatous polyposis, duodenal surgery, endoscopic surveillance, gastric neoplasia, jejunal neoplasia, Diseases of the digestive system. Gastroenterology, RC799-869
Published
2024
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10. In vitro study of radiosensitivity in colorectal cancer cell lines associated with Lynch syndrome

Author

Mingzhu Sun, Jayne Moquet, Stephen Barnard, Hannah Mancey, David Burling, Rachel Baldwin-Cleland, Kevin Monahan, Andrew Latchford, David Lloyd, Simon Bouffler, Christophe Badie, Nicola A. Anyamene, and Elizabeth Ainsbury

Subjects
Lynch syndrome, mismatch repair (MMR) deficiency, radiation effects, colorectal cancer cell lines, radiosensitivity, Public aspects of medicine, RA1-1270
Abstract

IntroductionLynch syndrome patients have an inherited predisposition to cancer due to a deficiency in DNA mismatch repair (MMR) genes which could lead to a higher risk of developing cancer if exposed to ionizing radiation. This pilot study aims to reveal the association between MMR deficiency and radiosensitivity at both a CT relevant low dose (20 mGy) and a therapeutic higher dose (2 Gy).MethodsHuman colorectal cancer cell lines with (dMMR) or without MMR deficiency (pMMR) were analyzed before and after exposure to radiation using cellular and cytogenetic analyses i.e., clonogenic assay to determine cell reproductive death; sister chromatid exchange (SCE) assay to detect the exchange of DNA between sister chromatids; γH2AX assay to analyze DNA damage repair; and apoptosis analysis to compare cell death response. The advantages and limitations of these assays were assessed in vitro, and their applicability and feasibility investigated for their potential to be used for further studies using clinical samples.ResultsResults from the clonogenic assay indicated that the pMMR cell line (HT29) was significantly more radio-resistant than the dMMR cell lines (HCT116, SW48, and LoVo) after 2 Gy X-irradiation. Both cell type and radiation dose had a significant effect on the yield of SCEs/chromosome. When the yield of SCEs/chromosome for the irradiated samples (2 Gy) was normalized against the controls, no significant difference was observed between the cell lines. For the γH2AX assay, 0, 20 mGy and 2 Gy were examined at post-exposure time points of 30 min (min), 4 and 24 h (h). Statistical analysis revealed that HT29 was only significantly more radio-resistant than the MLH1-deficient cells lines, but not the MSH2-deficient cell line. Apoptosis analysis (4 Gy) revealed that HT29 was significantly more radio-resistant than HCT116 albeit with very few apoptotic cells observed.DiscussionOverall, this study showed radio-resistance of the MMR proficient cell line in some assays, but not in the others. All methods used within this study have been validated; however, due to the limitations associated with cancer cell lines, the next step will be to use these assays in clinical samples in an effort to understand the biological and mechanistic effects of radiation in Lynch patients as well as the health implications.

Published
2024
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11. Bendamustine vs. fludarabine/cyclophosphamide lymphodepletion prior to BCMA CAR-T cell therapy in multiple myeloma

Author

Surbhi Sidana, Hitomi Hosoya, Alexandria Jensen, Lawrence Liu, Anmol Goyal, Vanna Hovanky, Bita Sahaf, Sushma Bharadwaj, Theresa Latchford, Sally Arai, Sheryl Leahy, Matthew Mei, Lihua E. Budde, Lori S. Muffly, Matthew J. Frank, Saurabh Dahiya, Myo Htut, David Miklos, and Murali Janakiram

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published
2023
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12. Gene-specific ACMG/AMP classification criteria for germline APC variants: Recommendations from the ClinGen InSiGHT Hereditary Colorectal Cancer/Polyposis Variant Curation Expert Panel

Author

Spier, Isabel, Yin, Xiaoyu, Richardson, Marcy, Pineda, Marta, Laner, Andreas, Ritter, Deborah, Boyle, Julie, Mur, Pilar, Hansen, Thomas v O., Shi, Xuemei, Mahmood, Khalid, Plazzer, John-Paul, Ognedal, Elisabet, Nordling, Margareta, Farrington, Susan M., Yamamoto, Gou, Baert-Desurmont, Stéphanie, Martins, Alexandra, Borras, Ester, Tops, Carli, Webb, Erica, Beshay, Victoria, Genuardi, Maurizio, Pesaran, Tina, Capellá, Gabriel, Tavtigian, Sean V., Latchford, Andrew, Frayling, Ian M., Plon, Sharon E., Greenblatt, Marc, Macrae, Finlay A., and Aretz, Stefan

Published
2024
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13. Germline de novo mutations in families with Mendelian cancer syndromes caused by defects in DNA repair

Author

Kitty Sherwood, Joseph C. Ward, Ignacio Soriano, Lynn Martin, Archie Campbell, Raheleh Rahbari, Ioannis Kafetzopoulos, Duncan Sproul, Andrew Green, Julian R. Sampson, Alan Donaldson, Kai-Ren Ong, Karl Heinimann, Maartje Nielsen, Huw Thomas, Andrew Latchford, Claire Palles, and Ian Tomlinson

Subjects
Science
Abstract

Abstract DNA repair defects underlie many cancer syndromes. We tested whether de novo germline mutations (DNMs) are increased in families with germline defects in polymerase proofreading or base excision repair. A parent with a single germline POLE or POLD1 mutation, or biallelic MUTYH mutations, had 3-4 fold increased DNMs over sex-matched controls. POLE had the largest effect. The DNMs carried mutational signatures of the appropriate DNA repair deficiency. No DNM increase occurred in offspring of MUTYH heterozygous parents. Parental DNA repair defects caused about 20–150 DNMs per child, additional to the ~60 found in controls, but almost all extra DNMs occurred in non-coding regions. No increase in post-zygotic mutations was detected, excepting a child with bi-allelic MUTYH mutations who was excluded from the main analysis; she had received chemotherapy and may have undergone oligoclonal haematopoiesis. Inherited DNA repair defects associated with base pair-level mutations increase DNMs, but phenotypic consequences appear unlikely.

Published
2023
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14. Treatment of Complex Desmoid Tumors in Familial Adenomatous Polyposis Syndrome by Intestinal Transplantation

Author

Emilio Canovai, MD, PhD, Andrew Butler, MD, PhD, Susan Clark, MD, PhD, Andrew Latchford, MD, PhD, Ashish Sinha, MD, PhD, Lisa Sharkey, MD, Charlotte Rutter, MD, Neil Russell, MD, Sara Upponi, MD, and Irum Amin, MD

Subjects
Surgery, RD1-811
Abstract

Background. Desmoid tumors are fibroblastic lesions which often have an unpredictable and variable clinical course. In the context of familial adenomatous polyposis (FAP), these frequently occur intra-abdominally, especially in the small-bowel mesentery resulting in sepsis, fistulation, and invasion of the abdominal wall and retroperitoneum. In selected cases where other modalities have failed, the most radical option is to perform a total enterectomy and intestinal transplantation (ITx). In this study, we present our center’s experience of ITx for desmoid in patients with FAP. Methods. We performed a retrospective review of our prospectively collected database between 2007 and 2022. All patients undergoing ITx for FAP-related desmoid were included. Results. Between October 2007 and September 2023, 144 ITx were performed on 130 patients at our center. Of these, 15 patients (9%) were for desmoid associated with FAP (7 modified multivisceral transplants, 6 isolated ITx, and 2 liver-containing grafts). The median follow-up was 57 mo (8–119); 5-y patient survival was 82%, all with functioning grafts without local desmoid recurrence. These patients presented us with several complex surgical issues, such as loss of abdominal domain, retroperitoneal/abdominal wall involvement, ileoanal pouch–related issues, and the need for foregut resection because of adenomatous disease. Conclusions. ITx is a viable treatment in selected patients with FAP and extensive desmoid disease. The decision to refer for ITx can be challenging, particularly the timing and sequence of treatment (simultaneous versus sequential exenteration). Delays can result in additional disease burden, such as secondary liver disease or invasion of adjacent structures.

Published
2024
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18. Cold snare polypectomy for duodenal adenomas in familial adenomatous polyposis: a prospective international cohort study

Author

Arthur S. Aelvoet, John G. Karstensen, Barbara A.J. Bastiaansen, Monique E. van Leerdam, Francesc Balaguer, Michal Kaminski, Roel Hompes, Patrick M.M. Bossuyt, Luigi Ricciardiello, Andrew Latchford, Rodrigo Jover, Maria Daca-Alvarez, Maria Pellisé, Evelien Dekker, and European FAP Consortium

Subjects
Familial adenomatous polyposis, Duodenal polyposis, Endoscopic resection, Diseases of the digestive system. Gastroenterology, RC799-869
Published
2023
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20. Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines

Author

Cavestro, Giulia Martina, Mannucci, Alessandro, Balaguer, Francesc, Hampel, Heather, Kupfer, Sonia S., Repici, Alessandro, Sartore-Bianchi, Andrea, Seppälä, Toni T., Valentini, Vincenzo, Boland, Clement Richard, Brand, Randall E., Buffart, Tineke E., Burke, Carol A., Caccialanza, Riccardo, Cannizzaro, Renato, Cascinu, Stefano, Cercek, Andrea, Crosbie, Emma J., Danese, Silvio, Dekker, Evelien, Daca-Alvarez, Maria, Deni, Francesco, Dominguez-Valentin, Mev, Eng, Cathy, Goel, Ajay, Guillem, Josè G., Houwen, Britt B.S.L., Kahi, Charles, Kalady, Matthew F., Kastrinos, Fay, Kühn, Florian, Laghi, Luigi, Latchford, Andrew, Liska, David, Lynch, Patrick, Malesci, Alberto, Mauri, Gianluca, Meldolesi, Elisa, Møller, Pål, Monahan, Kevin J., Möslein, Gabriela, Murphy, Caitlin C., Nass, Karlijn, Ng, Kimmie, Oliani, Cristina, Papaleo, Enrico, Patel, Swati G., Puzzono, Marta, Remo, Andrea, Ricciardiello, Luigi, Ripamonti, Carla Ida, Siena, Salvatore, Singh, Satish K., Stadler, Zsofia K., Stanich, Peter P., Syngal, Sapna, Turi, Stefano, Urso, Emanuele Damiano, Valle, Laura, Vanni, Valeria Stella, Vilar, Eduardo, Vitellaro, Marco, You, Yi-Qian Nancy, Yurgelun, Matthew B., Zuppardo, Raffaella Alessia, and Stoffel, Elena M.

Published
2023
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21. Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium

Author

Pål Møller, Toni Seppälä, James G. Dowty, Saskia Haupt, Mev Dominguez-Valentin, Lone Sunde, Inge Bernstein, Christoph Engel, Stefan Aretz, Maartje Nielsen, Gabriel Capella, Dafydd Gareth Evans, John Burn, Elke Holinski-Feder, Lucio Bertario, Bernardo Bonanni, Annika Lindblom, Zohar Levi, Finlay Macrae, Ingrid Winship, John-Paul Plazzer, Rolf Sijmons, Luigi Laghi, Adriana Della Valle, Karl Heinimann, Elizabeth Half, Francisco Lopez-Koestner, Karin Alvarez-Valenzuela, Rodney J. Scott, Lior Katz, Ido Laish, Elez Vainer, Carlos Alberto Vaccaro, Dirce Maria Carraro, Nathan Gluck, Naim Abu-Freha, Aine Stakelum, Rory Kennelly, Des Winter, Benedito Mauro Rossi, Marc Greenblatt, Mabel Bohorquez, Harsh Sheth, Maria Grazia Tibiletti, Leonardo S. Lino-Silva, Karoline Horisberger, Carmen Portenkirchner, Ivana Nascimento, Norma Teresa Rossi, Leandro Apolinário da Silva, Huw Thomas, Attila Zaránd, Jukka-Pekka Mecklin, Kirsi Pylvänäinen, Laura Renkonen-Sinisalo, Anna Lepisto, Päivi Peltomäki, Christina Therkildsen, Lars Joachim Lindberg, Ole Thorlacius-Ussing, Magnus von Knebel Doeberitz, Markus Loeffler, Nils Rahner, Verena Steinke-Lange, Wolff Schmiegel, Deepak Vangala, Claudia Perne, Robert Hüneburg, Aída Falcón de Vargas, Andrew Latchford, Anne-Marie Gerdes, Ann-Sofie Backman, Carmen Guillén-Ponce, Carrie Snyder, Charlotte K. Lautrup, David Amor, Edenir Palmero, Elena Stoffel, Floor Duijkers, Michael J. Hall, Heather Hampel, Heinric Williams, Henrik Okkels, Jan Lubiński, Jeanette Reece, Joanne Ngeow, Jose G. Guillem, Julie Arnold, Karin Wadt, Kevin Monahan, Leigha Senter, Lene J. Rasmussen, Liselotte P. van Hest, Luigi Ricciardiello, Maija R. J. Kohonen-Corish, Marjolijn J. L. Ligtenberg, Melissa Southey, Melyssa Aronson, Mohd N. Zahary, N. Jewel Samadder, Nicola Poplawski, Nicoline Hoogerbrugge, Patrick J. Morrison, Paul James, Grant Lee, Rakefet Chen-Shtoyerman, Ravindran Ankathil, Rish Pai, Robyn Ward, Susan Parry, Tadeusz Dębniak, Thomas John, Thomas van Overeem Hansen, Trinidad Caldés, Tatsuro Yamaguchi, Verónica Barca-Tierno, Pilar Garre, Giulia Martina Cavestro, Jürgen Weitz, Silke Redler, Reinhard Büttner, Vincent Heuveline, John L. Hopper, Aung Ko Win, Noralane Lindor, Steven Gallinger, Loïc Le Marchand, Polly A. Newcomb, Jane Figueiredo, Daniel D. Buchanan, Stephen N. Thibodeau, Sanne W. ten Broeke, Eivind Hovig, Sigve Nakken, Marta Pineda, Nuria Dueñas, Joan Brunet, Kate Green, Fiona Lalloo, Katie Newton, Emma J. Crosbie, Miriam Mints, Douglas Tjandra, Florencia Neffa, Patricia Esperon, Revital Kariv, Guy Rosner, Walter Hernán Pavicic, Pablo Kalfayan, Giovana Tardin Torrezan, Thiago Bassaneze, Claudia Martin, Gabriela Moslein, Aysel Ahadova, Matthias Kloor, Julian R. Sampson, Mark A. Jenkins, and The European Hereditary Tumour Group (EHTG) and the International Mismatch Repair Consortium (IMRC)

Subjects
Lynch Syndrome, Epidemiology, Prevention, Penetrance, Colorectal cancer, Segregation analysis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Genetics, QH426-470
Abstract

Abstract Objective To compare colorectal cancer (CRC) incidences in carriers of pathogenic variants of the MMR genes in the PLSD and IMRC cohorts, of which only the former included mandatory colonoscopy surveillance for all participants. Methods CRC incidences were calculated in an intervention group comprising a cohort of confirmed carriers of pathogenic or likely pathogenic variants in mismatch repair genes (path_MMR) followed prospectively by the Prospective Lynch Syndrome Database (PLSD). All had colonoscopy surveillance, with polypectomy when polyps were identified. Comparison was made with a retrospective cohort reported by the International Mismatch Repair Consortium (IMRC). This comprised confirmed and inferred path_MMR carriers who were first- or second-degree relatives of Lynch syndrome probands. Results In the PLSD, 8,153 subjects had follow-up colonoscopy surveillance for a total of 67,604 years and 578 carriers had CRC diagnosed. Average cumulative incidences of CRC in path_MLH1 carriers at 70 years of age were 52% in males and 41% in females; for path_MSH2 50% and 39%; for path_MSH6 13% and 17% and for path_PMS2 11% and 8%. In contrast, in the IMRC cohort, corresponding cumulative incidences were 40% and 27%; 34% and 23%; 16% and 8% and 7% and 6%. Comparing just the European carriers in the two series gave similar findings. Numbers in the PLSD series did not allow comparisons of carriers from other continents separately. Cumulative incidences at 25 years were < 1% in all retrospective groups. Conclusions Prospectively observed CRC incidences (PLSD) in path_MLH1 and path_MSH2 carriers undergoing colonoscopy surveillance and polypectomy were higher than in the retrospective (IMRC) series, and were not reduced in path_MSH6 carriers. These findings were the opposite to those expected. CRC point incidence before 50 years of age was reduced in path_PMS2 carriers subjected to colonoscopy, but not significantly so.

Published
2022
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22. Learning from parental experience in a neonatal surgical unit: a qualitative service evaluation

Author

Liz McKechnie, Bethan Johnson, Jonathan Sutcliffe, Elizabeth Lawson, Hemma Chauhan, Gurdeep S Sagoo, Anna Littlejohns, Gary Latchford, Emile Crouzen, Waaka Moni-Nwinia, Douglas McConachie, John G McElwaine, Fiona Metcalfe, Rebecca Mernenko, and Victoria Tricklebank

Subjects
Pediatrics, RJ1-570, Surgery, RD1-811
Abstract

Objectives Patient experience is directly related to health outcomes, and parental experience can be used as a proxy for this in neonatal care. This project was designed to assess parental experience of neonatal surgical care to inform future service developments and improve the care we provide.Methods This was a qualitative study using rapid qualitative analysis. The study was carried out in a large neonatal surgical intensive care unit in the UK. Parents of infants treated by the neonatal surgical team between March 2020 and February 2021, during the COVID-19 pandemic were included. Purposive sampling was used to ensure that a representative range of parents were interviewed. A semistructured interview was created and tested in a previous phase of work. This questionnaire was used to ask parents open questions about different aspects of their infants’ healthcare journey from the antenatal phase through to discharge from the neonatal unit (NUU).Results Rapid qualitative analysis was employed, and parental experiences were grouped into five main categories: before admission to the NNU, initial admission to NNU, information and support, COVID-19 and discharge. Within these five groups, we highlighted positive experiences to be fed back to the healthcare teams to reinforce good practice, areas that warranted improvement and suggestions for service development.Conclusions The wealth of data generated from the interviews has been summarized and shared with healthcare teams who are putting the service improvement suggestions into practice. The tool is available for services that wish to measure parental experience.

Published
2023
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23. Figure 1 from PIGA Mutations and Glycosylphosphatidylinositol Anchor Dysregulation in Polyposis-Associated Duodenal Tumorigenesis

Author

Meuser, Elena, primary, Chang, Kyle, primary, Walters, Angharad, primary, Hurley, Joanna J., primary, West, Hannah D., primary, Perry, Iain, primary, Mort, Matthew, primary, Reyes-Uribe, Laura, primary, Truscott, Rebekah, primary, Jones, Nicholas, primary, Lawrence, Rachel, primary, Jenkins, Gareth, primary, Giles, Peter, primary, Dolwani, Sunil, primary, Al-Sarireh, Bilal, primary, Hawkes, Neil, primary, Short, Emma, primary, Williams, Geraint T., primary, Taggart, Melissa W., primary, Luetchford, Kim, primary, Lynch, Patrick M., primary, Terlouw, Diantha, primary, Nielsen, Maartje, primary, Walton, Sarah-Jane, primary, Latchford, Andrew, primary, Clark, Susan K., primary, Sampson, Julian R., primary, Vilar, Eduardo, primary, and Thomas, Laura E., primary

Published
2024
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24. Supplementary Table S3 from PIGA Mutations and Glycosylphosphatidylinositol Anchor Dysregulation in Polyposis-Associated Duodenal Tumorigenesis

Author

Meuser, Elena, primary, Chang, Kyle, primary, Walters, Angharad, primary, Hurley, Joanna J., primary, West, Hannah D., primary, Perry, Iain, primary, Mort, Matthew, primary, Reyes-Uribe, Laura, primary, Truscott, Rebekah, primary, Jones, Nicholas, primary, Lawrence, Rachel, primary, Jenkins, Gareth, primary, Giles, Peter, primary, Dolwani, Sunil, primary, Al-Sarireh, Bilal, primary, Hawkes, Neil, primary, Short, Emma, primary, Williams, Geraint T., primary, Taggart, Melissa W., primary, Luetchford, Kim, primary, Lynch, Patrick M., primary, Terlouw, Diantha, primary, Nielsen, Maartje, primary, Walton, Sarah-Jane, primary, Latchford, Andrew, primary, Clark, Susan K., primary, Sampson, Julian R., primary, Vilar, Eduardo, primary, and Thomas, Laura E., primary

Published
2024
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25. Supplementary Figure S5 from PIGA Mutations and Glycosylphosphatidylinositol Anchor Dysregulation in Polyposis-Associated Duodenal Tumorigenesis

Author

Meuser, Elena, primary, Chang, Kyle, primary, Walters, Angharad, primary, Hurley, Joanna J., primary, West, Hannah D., primary, Perry, Iain, primary, Mort, Matthew, primary, Reyes-Uribe, Laura, primary, Truscott, Rebekah, primary, Jones, Nicholas, primary, Lawrence, Rachel, primary, Jenkins, Gareth, primary, Giles, Peter, primary, Dolwani, Sunil, primary, Al-Sarireh, Bilal, primary, Hawkes, Neil, primary, Short, Emma, primary, Williams, Geraint T., primary, Taggart, Melissa W., primary, Luetchford, Kim, primary, Lynch, Patrick M., primary, Terlouw, Diantha, primary, Nielsen, Maartje, primary, Walton, Sarah-Jane, primary, Latchford, Andrew, primary, Clark, Susan K., primary, Sampson, Julian R., primary, Vilar, Eduardo, primary, and Thomas, Laura E., primary

Published
2024
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26. Data from PIGA Mutations and Glycosylphosphatidylinositol Anchor Dysregulation in Polyposis-Associated Duodenal Tumorigenesis

Author

Meuser, Elena, primary, Chang, Kyle, primary, Walters, Angharad, primary, Hurley, Joanna J., primary, West, Hannah D., primary, Perry, Iain, primary, Mort, Matthew, primary, Reyes-Uribe, Laura, primary, Truscott, Rebekah, primary, Jones, Nicholas, primary, Lawrence, Rachel, primary, Jenkins, Gareth, primary, Giles, Peter, primary, Dolwani, Sunil, primary, Al-Sarireh, Bilal, primary, Hawkes, Neil, primary, Short, Emma, primary, Williams, Geraint T., primary, Taggart, Melissa W., primary, Luetchford, Kim, primary, Lynch, Patrick M., primary, Terlouw, Diantha, primary, Nielsen, Maartje, primary, Walton, Sarah-Jane, primary, Latchford, Andrew, primary, Clark, Susan K., primary, Sampson, Julian R., primary, Vilar, Eduardo, primary, and Thomas, Laura E., primary

Published
2024
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27. Figure 3 from PIGA Mutations and Glycosylphosphatidylinositol Anchor Dysregulation in Polyposis-Associated Duodenal Tumorigenesis

Author

Meuser, Elena, primary, Chang, Kyle, primary, Walters, Angharad, primary, Hurley, Joanna J., primary, West, Hannah D., primary, Perry, Iain, primary, Mort, Matthew, primary, Reyes-Uribe, Laura, primary, Truscott, Rebekah, primary, Jones, Nicholas, primary, Lawrence, Rachel, primary, Jenkins, Gareth, primary, Giles, Peter, primary, Dolwani, Sunil, primary, Al-Sarireh, Bilal, primary, Hawkes, Neil, primary, Short, Emma, primary, Williams, Geraint T., primary, Taggart, Melissa W., primary, Luetchford, Kim, primary, Lynch, Patrick M., primary, Terlouw, Diantha, primary, Nielsen, Maartje, primary, Walton, Sarah-Jane, primary, Latchford, Andrew, primary, Clark, Susan K., primary, Sampson, Julian R., primary, Vilar, Eduardo, primary, and Thomas, Laura E., primary

Published
2024
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28. Figure 2 from PIGA Mutations and Glycosylphosphatidylinositol Anchor Dysregulation in Polyposis-Associated Duodenal Tumorigenesis

Author

Meuser, Elena, primary, Chang, Kyle, primary, Walters, Angharad, primary, Hurley, Joanna J., primary, West, Hannah D., primary, Perry, Iain, primary, Mort, Matthew, primary, Reyes-Uribe, Laura, primary, Truscott, Rebekah, primary, Jones, Nicholas, primary, Lawrence, Rachel, primary, Jenkins, Gareth, primary, Giles, Peter, primary, Dolwani, Sunil, primary, Al-Sarireh, Bilal, primary, Hawkes, Neil, primary, Short, Emma, primary, Williams, Geraint T., primary, Taggart, Melissa W., primary, Luetchford, Kim, primary, Lynch, Patrick M., primary, Terlouw, Diantha, primary, Nielsen, Maartje, primary, Walton, Sarah-Jane, primary, Latchford, Andrew, primary, Clark, Susan K., primary, Sampson, Julian R., primary, Vilar, Eduardo, primary, and Thomas, Laura E., primary

Published
2024
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30. Personalized endoscopic surveillance and intervention protocols for patients with familial adenomatous polyposis: the European FAP Consortium strategy

Author

Arthur S. Aelvoet, Maria Pellisé, Barbara A.J. Bastiaansen, Monique E. van Leerdam, Rodrigo Jover, Francesc Balaguer, Michal F. Kaminski, John G. Karstensen, Jean-Christophe Saurin, Roel Hompes, Patrick M.M. Bossuyt, Luigi Ricciardiello, Andrew Latchford, and Evelien Dekker

Subjects
Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Background and study aims Patients with familial adenomatous polyposis (FAP) undergo colectomy and lifelong endoscopic surveillance to prevent colorectal, duodenal and gastric cancer. Endoscopy has advanced significantly in recent years, including both detection technology as well as treatment options. For the lower gastrointestinal tract, current guidelines do not provide clear recommendations for surveillance intervals. Furthermore, the Spigelman staging system for duodenal polyposis has its limitations. We present a newly developed personalized endoscopic surveillance strategy for the lower and upper gastrointestinal tract, aiming to improve the care for patients with FAP. We aim to inform centers caring for FAP patients and encourage the discussion on optimizing endoscopic surveillance and treatment in this high-risk population. Methods The European FAP Consortium, consisting of endoscopists with expertise in FAP, collaboratively developed new surveillance protocols. The proposed strategy was consensus-based and a result of several consortium meetings, discussing current evidence and limitations of existing systems. This strategy provides clear indications for endoscopic polypectomy in the rectum, pouch, duodenum and stomach and defines new criteria for surveillance intervals. This strategy will be evaluated in a 5-year prospective study in nine FAP expert centers in Europe. Results We present a newly developed personalized endoscopic surveillance and endoscopic treatment strategy for patients with FAP aiming to prevent cancer, optimize endoscopic resources and limit the number of surgical interventions. Following this new strategy, prospectively collected data in a large cohort of patients will inform us on the efficacy and safety of the proposed approaches.

Published
2023
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34. Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium

Author

Møller, Pål, Seppälä, Toni, Dowty, James G., Haupt, Saskia, Dominguez-Valentin, Mev, Sunde, Lone, Bernstein, Inge, Engel, Christoph, Aretz, Stefan, Nielsen, Maartje, Capella, Gabriel, Evans, Dafydd Gareth, Burn, John, Holinski-Feder, Elke, Bertario, Lucio, Bonanni, Bernardo, Lindblom, Annika, Levi, Zohar, Macrae, Finlay, Winship, Ingrid, Plazzer, John-Paul, Sijmons, Rolf, Laghi, Luigi, Valle, Adriana Della, Heinimann, Karl, Half, Elizabeth, Lopez-Koestner, Francisco, Alvarez-Valenzuela, Karin, Scott, Rodney J., Katz, Lior, Laish, Ido, Vainer, Elez, Vaccaro, Carlos Alberto, Carraro, Dirce Maria, Gluck, Nathan, Abu-Freha, Naim, Stakelum, Aine, Kennelly, Rory, Winter, Des, Rossi, Benedito Mauro, Greenblatt, Marc, Bohorquez, Mabel, Sheth, Harsh, Tibiletti, Maria Grazia, Lino-Silva, Leonardo S., Horisberger, Karoline, Portenkirchner, Carmen, Nascimento, Ivana, Rossi, Norma Teresa, da Silva, Leandro Apolinário, Thomas, Huw, Zaránd, Attila, Mecklin, Jukka-Pekka, Pylvänäinen, Kirsi, Renkonen-Sinisalo, Laura, Lepisto, Anna, Peltomäki, Päivi, Therkildsen, Christina, Lindberg, Lars Joachim, Thorlacius-Ussing, Ole, von Knebel Doeberitz, Magnus, Loeffler, Markus, Rahner, Nils, Steinke-Lange, Verena, Schmiegel, Wolff, Vangala, Deepak, Perne, Claudia, Hüneburg, Robert, de Vargas, Aída Falcón, Latchford, Andrew, Gerdes, Anne-Marie, Backman, Ann-Sofie, Guillén-Ponce, Carmen, Snyder, Carrie, Lautrup, Charlotte K., Amor, David, Palmero, Edenir, Stoffel, Elena, Duijkers, Floor, Hall, Michael J., Hampel, Heather, Williams, Heinric, Okkels, Henrik, Lubiński, Jan, Reece, Jeanette, Ngeow, Joanne, Guillem, Jose G., Arnold, Julie, Wadt, Karin, Monahan, Kevin, Senter, Leigha, Rasmussen, Lene J., van Hest, Liselotte P., Ricciardiello, Luigi, Kohonen-Corish, Maija R. J., Ligtenberg, Marjolijn J. L., Southey, Melissa, Aronson, Melyssa, Zahary, Mohd N., Samadder, N. Jewel, Poplawski, Nicola, Hoogerbrugge, Nicoline, Morrison, Patrick J., James, Paul, Lee, Grant, Chen-Shtoyerman, Rakefet, Ankathil, Ravindran, Pai, Rish, Ward, Robyn, Parry, Susan, Dębniak, Tadeusz, John, Thomas, van Overeem Hansen, Thomas, Caldés, Trinidad, Yamaguchi, Tatsuro, Barca-Tierno, Verónica, Garre, Pilar, Cavestro, Giulia Martina, Weitz, Jürgen, Redler, Silke, Büttner, Reinhard, Heuveline, Vincent, Hopper, John L., Win, Aung Ko, Lindor, Noralane, Gallinger, Steven, Le Marchand, Loïc, Newcomb, Polly A., Figueiredo, Jane, Buchanan, Daniel D., Thibodeau, Stephen N., ten Broeke, Sanne W., Hovig, Eivind, Nakken, Sigve, Pineda, Marta, Dueñas, Nuria, Brunet, Joan, Green, Kate, Lalloo, Fiona, Newton, Katie, Crosbie, Emma J., Mints, Miriam, Tjandra, Douglas, Neffa, Florencia, Esperon, Patricia, Kariv, Revital, Rosner, Guy, Pavicic, Walter Hernán, Kalfayan, Pablo, Torrezan, Giovana Tardin, Bassaneze, Thiago, Martin, Claudia, Moslein, Gabriela, Ahadova, Aysel, Kloor, Matthias, Sampson, Julian R., and Jenkins, Mark A.

Published
2022
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35. Phenotype Correlations With Pathogenic DNA Variants in the MUTYH Gene: A Review of Over 2000 Cases.

Author

Thet, Monica, Plazzer, John-Paul, Capella, Gabriel, Latchford, Andrew, Nadeau, Emily A. W., Greenblatt, Marc S., Macrae, Finlay, and Aziz, Aziz ur Rehman

Abstract

MUTYH‐associated polyposis (MAP) is an autosomal recessive disorder where the inheritance of constitutional biallelic pathogenic MUTYH variants predisposes a person to the development of adenomas and colorectal cancer (CRC). It is also associated with extracolonic and extraintestinal manifestations that may overlap with the phenotype of familial adenomatous polyposis (FAP). Currently, there are discrepancies in the literature regarding whether certain phenotypes are truly associated with MAP. This narrative review is aimed at exploring the phenotypic spectrum of MAP to better characterize the MAP phenotype. Literature search was conducted to identify articles reporting on MAP‐specific phenotypes. Clinical data from 2109 MAP patients identified from the literature showed that 1123 patients (53.2%) had CRC. Some patients with CRC had no associated adenomas, suggesting that adenomas are not an obligatory component of MAP. Carriers of the two missense founder variants, and possibly truncating variants, had an increased cancer risk when compared to those who carry other pathogenic variants. It has been suggested that somatic G:C > T:A transversions are a mutational signature of MAP and could be used as a biomarker in screening and identifying patients with atypical MAP, or in associating certain phenotypes with MAP. The extracolonic and extraintestinal manifestations that have been associated with MAP include duodenal adenomas, duodenal cancer, fundic gland polyps, gastric cancer, ovarian cancer, bladder cancer, and skin cancer. The association of breast cancer and endometrial cancer with MAP remains disputed. Desmoid tumors and congenital hypertrophy of the retinal pigment epithelium (CHRPEs) are rarely reported in MAP but have long been seen in FAP patients and thus could act as a distinguishing feature between the two. This collection of MAP phenotypes will assist in the assessment of pathogenic MUTYH variants using the American College of Medical Genetics and the Association for Molecular Pathology (ACMG/AMP) Variant Interpretation Guidelines and ultimately improve patient care. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Juvenile polyposis syndrome in children: The impact of SMAD4 and BMPR1A mutations on clinical phenotype and polyp burden

Author

Cohen, Shlomi, primary, Yerushalmy‐Feler, Anat, additional, Rojas, Isabel, additional, Phen, Claudia, additional, Rudnick, David A., additional, Flahive, Colleen B., additional, Erdman, Steven H., additional, Magen‐Rimon, Ramit, additional, Copova, Ivana, additional, Attard, Thomas, additional, Latchford, Andrew, additional, and Hyer, Warren, additional

Published
2024
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38. Updated European guidelines for clinical management of familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), gastric adenocarcinoma, proximal polyposis of the stomach (GAPPS) and other rare adenomatous polyposis syndromes: a joint EHTG-ESCP revision

Author

Zaffaroni, Gloria, primary, Mannucci, Alessandro, additional, Koskenvuo, Laura, additional, de Lacy, Borja, additional, Maffioli, Anna, additional, Bisseling, Tanya, additional, Half, Elizabeth, additional, Cavestro, Giulia Martina, additional, Valle, Laura, additional, Ryan, Neil, additional, Aretz, Stefan, additional, Brown, Karen, additional, Buttitta, Francesco, additional, Carneiro, Fatima, additional, Claber, Oonagh, additional, Blanco-Colino, Ruth, additional, Collard, Maxime, additional, Crosbie, Emma, additional, Cunha, Miguel, additional, Doulias, Triantafyllos, additional, Fleming, Christina, additional, Heinrich, Henriette, additional, Hüneburg, Robert, additional, Metras, Julie, additional, Nagtegaal, Iris, additional, Negoi, Ionut, additional, Nielsen, Maartje, additional, Pellino, Gianluca, additional, Ricciardiello, Luigi, additional, Sagir, Abdurrahman, additional, Sánchez-Guillén, Luis, additional, Seppälä, Toni T, additional, Siersema, Peter, additional, Striebeck, Benedikt, additional, Sampson, Julian R, additional, Latchford, Andrew, additional, Parc, Yann, additional, Burn, John, additional, and Möslein, Gabriela, additional

Published
2024
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41. PIGA mutations and glycosylphosphatidylinositol anchor dysregulation in polyposis-associated duodenal tumorigenesis

Author

Meuser, Elena, primary, Chang, Kyle, additional, Walters, Angharad, additional, Hurley, Joanna J., additional, West, Hannah D., additional, Perry, Iain, additional, Mort, Matthew, additional, Reyes-Uribe, Laura, additional, Truscott, Rebekah, additional, Jones, Nicholas, additional, Lawrence, Rachel, additional, Jenkins, Gareth, additional, Giles, Peter, additional, Dolwani, Sunil, additional, Al-Sarireh, Bilal, additional, Hawkes, Neil, additional, Short, Emma, additional, Williams, Geraint T., additional, Taggart, Melissa W., additional, Luetchford, Kim, additional, Lynch, Patrick M., additional, Terlouw, Diantha, additional, Nielsen, Maartje, additional, Walton, Sarah-Jane, additional, Latchford, Andrew, additional, Clark, Susan K., additional, Sampson, Julian R., additional, Vilar, Eduardo, additional, and Thomas, Laura E., additional

Published
2024
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45. Incidence and risk factors associated with bleeding and thrombosis following chimeric antigen receptor T-cell therapy

Author

Johnsrud, Andrew, Craig, Juliana, Baird, John, Spiegel, Jay, Muffly, Lori, Zehnder, James, Tamaresis, John, Negrin, Robert, Johnston, Laura, Arai, Sally, Shizuru, Judith, Lowsky, Robert, Meyer, Everett, Weng, Wen-Kai, Shiraz, Parveen, Rezvani, Andrew, Latchford, Theresa, Mackall, Crystal, Miklos, David, Frank, Matthew, and Sidana, Surbhi

Published
2021
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47. Variation in the risk of colorectal cancer in families with Lynch syndrome: a retrospective cohort study

Author

Win, Aung Ko, Dowty, James G., Reece, Jeanette C., Lee, Grant, Templeton, Allyson S., Plazzer, John-Paul, Buchanan, Daniel D., Akagi, Kiwamu, Aksoy, Seçil, Alonso, Angel, Alvarez, Karin, Amor, David J., Ankathil, Ravindran, Aretz, Stefan, Arnold, Julie L., Aronson, Melyssa, Austin, Rachel, Backman, Ann-Sofie, Bajwa-ten Broeke, Sanne W., Barca-Tierno, Verónica, Barwell, Julian, Bernstein, Inge, Berthet, Pascaline, Betz, Beate, Bignon, Yves-Jean, Boisjoli, Talya, Bonadona, Valérie, Briollais, Laurent, Brunet, Joan, Bucksch, Karolin, Buecher, Bruno, Buettner, Reinhard, Burn, John, Caldés, Trinidad, Capella, Gabriel, Caron, Olivier, Casey, Graham, Chew, Min H., Choi, Yun-hee, Church, James, Clendenning, Mark, Colas, Chrystelle, Cops, Elisa J., Coupier, Isabelle, Cruz-Correa, Marcia, de la Chapelle, Albert, de Wind, Niels, Dębniak, Tadeusz, Della Valle, Adriana, Delnatte, Capuccine, Dhooge, Marion, Dominguez-Valentin, Mev, Drouet, Youenn, Duijkers, Floor A., Engel, Christoph, Esperon, Patricia, Evans, D. Gareth, Falcón de Vargas, Aída, Figueiredo, Jane C, Foulkes, William, Fourme, Emmanuelle, Frebourg, Thierry, Gallinger, Steven, Garre, Pilar, Genuardi, Maurizio, Gerdes, Anne-Marie, Gima, Lauren M., Giraud, Sophie, Goodwin, Annabel, Görgens, Heike, Green, Kate, Guillem, Jose, Guillén-Ponce, Carmen, Guimbaud, Roselyne, Guindalini, Rodrigo S.C., Half, Elizabeth E., Hall, Michael J, Hampel, Heather, Hansen, Thomas V.O., Heinimann, Karl, Hes, Frederik J., Hill, James, Ho, Judy W.C., Holinski-Feder, Elke, Hoogerbrugge, Nicoline, Hüneburg, Robert, Huntley, Vanessa, James, Paul A., Jensen, Uffe B, John, Thomas, Juhari, Wan K.W., Kalady, Matthew, Kastrinos, Fay, Kloor, Matthias, Kohonen-Corish, Maija RJ, Krogh, Lotte N., Kupfer, Sonia S., Ladabaum, Uri, Lagerstedt-Robinson, Kristina, Lalloo, Fiona, Lasset, Christine, Latchford, Andrew, Laurent-Puig, Pierre, Lautrup, Charlotte K., Leggett, Barbara A., Lejeune, Sophie, LeMarchand, Loic, Ligtenberg, Marjolijn, Lindor, Noralane, Loeffler, Markus, Longy, Michel, Lopez, Francisco, Lowery, Jan, Lubiński, Jan, Lucassen, Anneke M, Lynch, Patrick M., Malińska, Karolina, Matsubara, Nagahide, Mecklin, Jukka-Pekka, Møller, Pål, Monahan, Kevin, Morrison, Patrick J., Nattermann, Jacob, Navarro, Matilde, Neffa, Florencia, Neklason, Deborah, Newcomb, Polly A., Ngeow, Joanne, Nichols, Cassandra, Nielsen, Maartje, Nixon, Dawn M., Nogues, Catherine, Okkels, Henrik, Olschwang, Sylviane, Pachter, Nicholas, Pai, Rish K., Palmero, Edenir I., Pande, Mala, Parry, Susan, Patel, Swati G., Pearlman, Rachel, Perne, Claudia, Pineda, Marta, Poplawski, Nicola K, Pylvänäinen, Kirsi, Qiu, Jay, Rahner, Nils, Ramesar, Raj, Rasmussen, Lene J., Redler, Silke, Reis, Rui M., Ricciardiello, Luigi, Rogoża-Janiszewska, Emilia, Rosty, Christophe, Samadder, N. Jewel, Sampson, Julian R., Schackert, Hans K., Schmiegel, Wolff, Schulmann, Karsten, Schuster, Helène, Scott, Rodney, Senter, Leigha, Seppälä, Toni T, Shtoyerman, Rakefet, Sijmons, Rolf H., Snyder, Carrie, Solomon, Ilana B., Soto, Jose Luis, Southey, Melissa C., Spigelman, Allan, Spirandelli, Florencia, Spurdle, Amanda B., Steinke-Lange, Verena, Stoffel, Elena M., Strassburg, Christian P., Sunde, Lone, Susman, Rachel, Syngal, Sapna, Tanakaya, Kohji, Tezcan, Gülçin, Therkildsen, Christina, Thibodeau, Steve, Tomita, Naohiro, Tucker, Katherine M., Tunca, Berrin, Turchetti, Daniela, Uhrhammer, Nancy, Utsunomiya, Joji, Vaccaro, Carlos, van Duijnhoven, Fränzel J.B., van Wanzeele, Meghan J., Vangala, Deepak B., Vasen, Hans F.A., von Knebel Doeberitz, Magnus, von Salomé, Jenny, Wadt, Karin A.W., Ward, Robyn L., Weitz, Jürgen, Weitzel, Jeffrey N., Williams, Heinric, Winship, Ingrid, Wise, Paul E., Wods, Julie, Woods, Michael O., Yamaguchi, Tatsuro, Zachariae, Silke, Zahary, Mohd N., Hopper, John L., Haile, Robert W., Macrae, Finlay A., Möslein, Gabriela, and Jenkins, Mark A.

Published
2021
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50. Immune reconstitution and infectious complications following axicabtagene ciloleucel therapy for large B-cell lymphoma

Author

Baird, John H., Epstein, David J., Tamaresis, John S., Ehlinger, Zachary, Spiegel, Jay Y., Craig, Juliana, Claire, Gursharan K., Frank, Matthew J., Muffly, Lori, Shiraz, Parveen, Meyer, Everett, Arai, Sally, Brown, Janice (Wes), Johnston, Laura, Lowsky, Robert, Negrin, Robert S., Rezvani, Andrew R., Weng, Wen-Kai, Latchford, Theresa, Sahaf, Bita, Mackall, Crystal L., Miklos, David B., and Sidana, Surbhi

Published
2021
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