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Abstract In this study, we evaluated the combined effect between MLE-15, a modular lytic enzyme composed of four building blocks, and reline, a natural deep eutectic solvent. The bioinformatic analysis allowed us to determine the spatial architecture of MLE-15, whose components were bactericidal peptide cecropin A connected via a flexible linker to the cell wall binding domain (CBD) of mesophilic 201ϕ2 − 1 endolysin and catalytic domain (EAD) of highly thermostable Ph2119 endolysin. The modular enzyme showed high thermostability with the melting temperature of 93.97 ± 0.38 °C, significantly higher than their natural counterparts derived from mesophilic sources. The minimum inhibitory concentration (MIC) of MLE-15 was 100 µg/mL for a panel of Gram-positive and Gram-negative bacteria, while the MIC of reline ranged from 6.25 to 25% v/v for the same strains. The addition of reline effectively reduced the MIC of MLE-15 from 100 µg/mL to 3.15–50 µg/mL. This combination displayed additive effects for most strains and synergism for extensively antibiotic-resistant Acinetobacter baumannii and Bacillus subtilis. The subsequent evaluation revealed that MLE-15 eliminated planktonic cells of A. baumannii RUH134, but was ineffective against matured biofilms. However, combined with reline, MLE-15 reduced the bacterial load in the matured biofilm by 1.39 log units. Confocal fluorescence microscopy indicated that reline damaged the structure of the biofilm, allowing MLE-15 to penetrate it. Additionally, MLE-15 and its combination with reline eradicated meropenem-persistent cells of A. baumannii RUH134. Effectiveness in lowering the MIC value of MLE-15 as well as protection against antibiotic-tolerant persister cells, indicate that MLE-15 and reline combination is a promising candidate for effective therapies in bacterial infections, which is especially important in the light of the global crisis of antimicrobial resistance.

Strategies for successful healing of diabetic wounds are lacking. Natural-derived dressings have gained much attention due to their promising properties. We hypothesized that keratin-biphalin fiber-dressing accelerates skin wound healing in a mouse model of diabetes. Keratin fibers were obtained from mouse fur and soaked in a biphalin solution. Studies on NIH/3T3 cells showed that keratin-biphalin fibers increase cell viability. In vivo studies were made on C57BL/6J mice with iatrogenically induced diabetes. Two full-thickness wounds were created on the back of the mice, one untreated and the other treated with an experimental dressing. Western blot analysis, histopathological and immunohistochemical staining were performed. Biphalin was slowly released from keratin fibers. The obtained keratin-biphalin fibers were biocompatible and supported cell growth. Western blot analysis showed that cells treated with our dressing had an increasing expression level of mTOR, and p-AKT 72 h post-treatment compared to 24 h and 48 h. Animal studies showed that the keratin-biphalin dressing accelerated wound healing on days 5 and 15. Treated wounds showed faster reepithelization and developed thicker epidermis. Histopathological and immunohistochemical studies confirmed that keratin-biphalin fibers stimulate macrophage infiltration, which promotes tissue remodeling and regeneration. Exogenous keratin-biphalin fibers p-AKT/mTOR expression protein in vitro and accelerate skin wound healing in diabetic mice.

Nosocomial infections means the penetration, and the development of a biological pathogenic factor in the body, which occurred in connection with the impartation of health services. These infections affect 5 to 10% of patients. Most of the hospital staff do not know or ignore the rules for reducing infections in healthcare facilities. In Poland, there is a shortage of epidemiological nurses, doctors specializing in epidemiology, bacteriology and microbiology, and statements about their position in the structure of hospital management structure. The most difficult to combat are MDRO. They are most often carried by non-disinfected hands and medical equipment, outdated ventilation and air-conditioning installations and drainage of water from healthcare facilities. In order to limit the transmission of infectious microorganisms as much as possible, health services provided in health care facilities should be properly organized. Medical personnel should be properly trained, and cleaning staff should be equipped with adequate cleaning and disinfection agents. Each medical facility should define a hospital environment monitoring program in which the rules for limiting the transmission of infectious pathogens are clearly defined. Additionally, a program should be created to encourage the selection of specializations in epidemiological and related fields for doctors and nurses in order to increase the number of personnel with such degree and direction of education.

Central nervous system infections are among the most devastating infections in the world. Pathogens may enter the central nervous system as a result of dissemination from the upper respiratory tract or other primary site via blood and then crossing the blood-brain barrier. Pathogens present in health care facilities are not an exception. In addition, the neurosurgical procedures performed there are an additional way of entering the central nervous system. Moreover, nosocomial infections are characterized by very high morbidity and mortality, therefore their early diagnosis and treatment is important. The aim of the study is to review the current knowledge and guidelines on the most common healthcare-associated infections of the central nervous system, their diagnosis and treatment. Information searches were carried out in online databases, scientific and educational editions. The most common healthcare-associated infection of the central nervous system is meningitis, followed by a subdural empyema and a brain abscess. The greatest risk factor is neurosurgery. In all of the most common infections of the central nervous system listed, rapid implementation of empiric antibiotic therapy is essential. Further antibiotic therapy depends on the identified etiological factor. As a rule, surgical treatment is required for subdural empyema and brain abscesses. Healthcare-related central nervous system infections remain a significant problem. Due to the risk posed by them to the patient's health, prophylaxis, prompt diagnosis and treatment are essential.

This article uses bibliometric tools to analyze the peer-reviewed publications of academic librarians from 32 accredited higher education institutions in Norway--10 university libraries and 22 college libraries--associate members of Universities Norway (UHR). The period 2016-2020 was chosen to enable us to better understand publication patterns among this academic group over a meaningful timeframe. Research outputs were examined in terms of productivity by institution, document types, publication years, subject categories, open access status, and collaboration patterns. The findings indicate that publishing amongst this community is growing; librarians choose the most highly regarded publication channels in the same way as other faculty members, and they publish in partnership with other researchers. The analysis found that academic librarians frequently select Open Access publication pathways.

Unemployment is one of the most important problems affecting people in all countries. It affects the functioning of entire economies, industries, and enterprises; it also reduces the level and quality of people’s lives. The dynamic changes that are taking place in the labor market are forcing entrepreneurs to adopt a flexible approach to labor market resources – that is, employees – and also to choose appropriate forms of human capital management. This may lead to a reduction in unemployment in the market. Consequently, tackling unemployment is one of the important challenges facing the European Union, especially on its way to achieving sustainable development goals. High levels of unemployment could significantly hamper the achievement of the Agenda 2030 employment targets (SDG8), leading to poverty, social and economic inequality, and social instability. Therefore, the subject of this study is unemployment in EU countries; the main objective is to examine unemployment levels across EU member states. The deliberations and analysis are carried out in the context of the Agenda 2030 Goal 8 (SDG 8) for sustainable development. Taking into account the different degrees of implementation of SDG8 by individual Member States, and thus the different results in this respect, the study finds differences and similarities among the surveyed Member States in terms of types and levels of unemployment. The research is based on Eurostat data for 2022, and uses multidimensional comparative analysis methods such as cluster analysis and linear ordering. A review of selected sources on international and European law focuses on employment policy standards, including the problem of unemployment; this serves as a background for the analyses. The considerations are embedded in the concept of sustainable development, which influences the functioning of entire economies, but also in the processes of enterprise management. Based on the literature and the results of the analyses, it is concluded that levels of unemployment vary greatly in the analyzed countries. The best conditions for availability and accessibility of work are found in the Czech Republic and Malta; the worst are in Spain and Greece, where unemployment is very high.

Funding information: International Visegrad Fund Grant Number IVF 22230264. This article presents the results of a survey conducted in the first half of 2023. A total of 812 questionnaires were obtained from current and potential consumers (individual and B2B) in the Visegrad countries. The survey’s goal was to find out how consumers perceive and evaluate the quality and pro-ecological factors/challenges of the products of the electrical machinery industry, in the context of their declared personal purchases. Among other things, it sought to establish the actions consumers expect from manufacturers if they want to increase the market share of good-quality and environmentally friendly products. Improvements to the quality of products, with reductions in their negative environmental impact throughout their life cycle, were noticed most in Hungary and Poland. In all countries surveyed, consumers agreed most strongly with the statement that to increase the market share of good quality and environmentally friendly products, producers should enable recycling, disposal, and so on, and improve the availability of information.

Hydrogen is expected to be one of the most important fuels meeting stringent emission standards shortly. Using hydrogen as a fuel in an internal combustion engine (ICE) is an alternative application to replace hydrocarbon fuels that, when burned, produce harmful gases such as carbon monoxide and hydrocarbons, particulate matter, and greenhouse gases. This work provides an overview of the latest research results and future challenges and opportunities related to the use of hydrogen to power ICEs. The article presents the work of various research centres describing the technical use of hydrogen as a fuel in motor vehicles with combustion engines. Specific chemical and physical properties of hydrogen used in combustion engines were presented. The article presents modern research on a hydrogen-powered ICE. First, the basics of hydrogen engines are described, examining the engine-specific properties of hydrogen, followed by a review of the existing literature. Attention was paid to the fundamental importance of optimising the air composition from the point of view of combustion quality, NOx emissions, engine efficiency, and performance. Another issue under consideration is cleaning exhaust gases to meet future emissions regulations for hydrogen-fuelled combustion engines.

Objectives Running a business effectively requires ensuring continuity and regularity of the activity. For this purpose, it is important to effectively and rationally manage inventories and maintain them at various levels of optimality. Material and methods In the paper a design of the probabilistic model of reserves is discussed. The objective was an elaboration of the optimal strategy of materials reserves management in the series manufacturing. Results The model has been verified at an attainable scale using the numerical data concerning different assortment of materials in the serial production of furniture. The proposed probabilistic model makes it possible to elaborate the optimal strategy of type R, Z in the management of reserves of based materials of the manufacturing company with large-lot production. The strategy is based on minimal expenses connected with a supply of materials. Conclusions For each company to provide good quality services, it is necessary for individual, cooperating enterprises to function efficiently. The so-called "supply chain" is a specific sequence of activities enabling the satisfaction of market demand for a given product. The supply chain consists of companies and plants that are involved in supplying raw materials, processing them into semi-finished products and, ultimately, creating a finished product. The simplest supply chain consists of a company, suppliers and customers. However, it is good to know that many more companies are involved in most production processes, including transport, logistics, finance and IT.

Abstrakt Housing policy aspiring to have a general social impact, subtracting from the scale of the state, like any other policy in this scope, is conducted in the European Union countries by the public sector. This sector remains a significant point of reference for this policy. The activity of the public sector in the countries of post-war Western Europe varies in intensity over time and is carried out at different spatial levels - also in relation to housing. The public sector has been subject to a tendency towards apparent self-limitation for at least the last four decades. This occurs mainly by reducing the importance of the state and its agencies in socio-economic development. Housing policy is one of the important sectoral policies of the state - including the government and local authorities - engaging public entities, political and social organizations and private entities to achieve the main and long-term goals in the area of housing, which are: creating conditions for purchasing or renting apartments by all citizens; ensuring the availability of the housing stock, i.e. implementing an appropriate scale of housing investments using primarily the market mechanism, and supporting the appropriate quality of the housing stock throughout the entire period of use of the property.

Background/Objectives: Camptothecin (CPT) is a well-known chemical compound recognized for its significant anticancer properties. However, its clinical application remains limited due to challenges related to CPT’s high hydrophobicity and the instability of its active form. To address these difficulties, our research focused on the development of four novel nanoparticulate systems intended for either oral or intravenous administration. Methods: These nanosystems were based on a poly(amidoamine) (PAMAM) dendrimer/CPT complex, which had been coated with biodegradable homo- and copolymers, designed with appropriate physicochemical properties and chain microstructures. Results: The resulting nanomaterials, with diameters ranging from 110 to 406 nm and dispersity values between 0.10 and 0.67, exhibited a positive surface charge and were synthesized using biodegradable poly(L-lactide) (PLLA), poly(L-lactide-co-ε-caprolactone) (PLACL), and poly(glycolide-co-ε-caprolactone) (PGACL). Biological assessments, including cell viability and hemolysis tests, indicated that all polymers demonstrated less than 5% hemolysis, confirming their hemocompatibility for potential intravenous use. Furthermore, fibroblasts exposed to these matrices showed concentration-dependent viability. The entrapment efficiency (EE) of CPT reached up to 27%, with drug loading (DL) values as high as 17%. The in vitro drug release studies lasted over 400 h with the use of phosphate buffer solutions at two different pH levels, demonstrating that time-dependent processes allowed for a gradual and controlled release of CPT from the developed nanosystems. The release kinetics of the active compound at pH 7.4 ± 0.05 and 6.5 ± 0.05 followed near-first-order or first-order models, with diffusion and Fickian/non-Fickian transport mechanisms. Importantly, the nanoparticulate systems enabled the stabilization of the pharmacologically active form of CPT, while providing protection against hydrolysis, even in physiological environments. Conclusions: In our opinion, these results underscore the promising future of biodegradable nanosystems as effective drug delivery systems (DDSs) for targeted cancer treatment, offering stability and efficacy over short, medium, and long-term applications.

This research examines the influence of various pavement types on vehicle dynamics, specifically concentrating on vertical acceleration and its implications for unsprung mass, including the wheels and suspension system. The objective of this project was to categorize pavement types with accelerometer data, enabling a deeper comprehension of the impact of road surface conditions on vehicle stability, comfort, and mechanical stress. Two categorization methods were utilized: a neural network and a multinomial logistic regression model. Accelerometer data were gathered while a car navigated diverse terrain types, such as grates, potholes, and cobblestones. The neural network model exhibited exceptional performance, with 100% accuracy in categorizing all surface types, while the multinomial logistic regression model reached 97.14% accuracy. The neural network demonstrated exceptional efficacy in differentiating intricate surface types such as potholes and grates, surpassing the logistic regression model which had difficulties with these surfaces. These results underscore the neural network’s effectiveness in the real-time categorization of road surfaces, enhancing the comprehension of vehicle dynamics influenced by pavement conditions. Future studies must tackle the difficulty of identifying analogous surfaces by enhancing methodologies or integrating more data attributes for greater precision.

Background: A child’s cancer is a highly stressful experience for the entire family. Childhood cancer disrupts family functioning and is one of the most stressful and challenging events parents face, often beyond their control. Parents play a crucial role in providing emotional support to children throughout their illness, and their ability to cope can help reduce the child’s negative emotions. The aim of this study was to assess the prevalence of anxiety and depression among parents of children with cancer. Methods: This cross-sectional study followed the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines and included parents of children undergoing cancer treatment. Convenience sampling was used. The Beck Depression Inventory and the Hospital Anxiety and Depression Scale were utilized to assess the parents. Results: This study included 270 participants (73% women, 27% men) with children at an average age of 8.75 ± 4.82 years. Diagnoses included leukemia (53%), lymphoma (29%), and other cancers. On the Beck Depression Inventory, 33% of parents were mildly depressed, 12% moderately depressed, and 32% severely depressed, with an average score of 20.63 ± 12.39 points. The HADS-M scale indicated anxiety at 48.43 ± 20.78%, depression at 45.01 ± 22.8%, and aggression at 54.72 ± 28.71%. Conclusions: Most parents of children with cancer have symptoms of depression and anxiety, which are influenced by the duration of the child’s illness. A strong correlation was observed between the level of anxiety and the tendency for depression.

The aim of this article is to examine which selected internal factors influence the profitability (ROA) of companies in the energy sector in Poland and how they do so, over the period 2018–2021, taking into account two groups: all types of activities (984 companies) and electricity production (508 companies). This study uses Pearson correlation analysis, Wilcoxon pairwise rank test, descriptive statistics and multiple linear regression to build eight ROA econometric models, four for each group. The research shows that in the energy sector, in particular, variables relating to the capital structure (total equity/total assets, long-term liabilities/total assets, short-term liabilities/total assets and long-term liabilities/short-term liabilities ratios) have a statistically significant impact (positive or negative) on the profitability (ROA). The aforementioned ratios appear in various combinations in all eight ROA models. The use of equity to finance the activities of companies in this sector seems to be particularly beneficial, as the total equity/total assets ratio occurs in as many as seven out of eight models and, moreover, it always has a positive impact on the ROA. The remaining analyzed variables relating to the structure of assets (fixed assets/total assets ratio), financial liquidity (current ratio) and the age of the company appear in the models as statistically significant quite rarely, having a different impact on the ROA (positively or negatively). However, variables such as the fixed assets/current assets and total liabilities/total equity ratios do not have a statistically significant impact on the ROA at all in any of the studied groups of enterprises. The research results suggest that managers, in order to shape profitability (measured by ROA), should pay special attention to the capital structure, i.e., the proportions of the use of equity, long-term liabilities and short-term liabilities to finance the operations of energy companies as these independent variables appear most often in ROA models. Other analyzed factors, such as the assets structure (the share of fixed assets in total assets) or financial liquidity, also have an impact on the return on assets; therefore, their use in energy companies should also be considered. Moreover, the research shows a large diversity of factors shaping ROA in econometric models, the way they affect the dependent variable (positive or negative) and the degree of model fit (R2), both in individual years and in the two groups of companies studied. This proves that it is not possible to clearly and finally determine which factors and how (positive or negative) they affect the profitability. This influence can change over time depending on the circumstances, which indicates the need for the continuous involvement of decision makers in the management process and making decisions based on reliable and appropriate-to-the-situation analyses.

Artificial neural network models for the task of detection are used in many fields and find various applications. Models of this kind require adequate computational resources and thus require adequate energy expenditure. The increase in the number of parameters, the complexity of architectures, and the need to process large data sets significantly increase energy consumption, which is becoming a key sustainability challenge. Optimization of computing and the development of energy-efficient hardware technologies are essential to reduce the energy footprint of these models. This article examines the effect of the type of model, as well as its parameters, on energy consumption during inference. For this purpose, sensors built into the graphics card were used, and software was developed to measure the energy demand of the graphics card for different architectures of YOLO models (v8, v9, v10), as well as for different batch and model sizes. This study showed that the increase in energy demand is not linearly dependent on batch size. After a certain level of batch size, the energy demand begins to decrease. This dependence does not occur only for n/t size models. Optimum utilization of computing power due to the number of processed images for the studied models occurs at the maximum studied batch size. In addition, tests were conducted on an embedded device.

Energy consumption in electric vehicles is a key element of their operation, determining energy efficiency and one of its main indicators, i.e., range. Therefore, in this article, mathematical models were developed to evaluate the impact of selected factors on energy consumption in electric vehicles. The phenomenon of energy recuperation was also examined. The study used data from mileage measurements of the electric vehicle (EV) driving on a motorway and in built-up areas. The results obtained showed a strong correlation between acceleration, vehicle speed, battery power, and energy consumption. In urban conditions, engine RPM and vehicle speed had an additional impact on energy consumption. Findings from this study can be used to optimize vehicle acceleration control modules to increase their range, develop eco-driving styles for EV drivers, and better understand the energy efficiency factors of EVs.

The growing demand for personal mobility is leading to an increase in vehicle use, which is in turn contributing to higher carbon emissions. It is widely acknowledged that emission-free electric vehicles (EVs) will play a pivotal role in the decarbonization process, particularly in the decarbonization of transport systems. The objective of this paper was to present the trends in demand for electric vehicles (EVs) in Poland, together with the identification of market shocks and an assessment of the programs supporting electromobility. The number of imported and domestically purchased new and used electric vehicle (BEV) registrations was analyzed using the TRAMO-SEATS and ARIMA-X-12 seasonal adjustment methods. The rise in sales of electric vehicles in Poland was driven by the government’s electromobility support programs and alterations to tax legislation, with no discernible seasonal impact. The number of registrations in Poland increased significantly, exhibiting an upward trajectory. However, this growth is constrained by the inadequate number of charging stations, which are primarily powered by electricity derived from coal. Consequently, while the development of electromobility in Poland is evident, the decarbonization process remains a challenge.

A series of phenyl β-carbonyl selenides with o-ester functionality substituted on the oxygen atom with chiral and achiral alkyl groups was synthesized. All compounds are the first examples of this type of organoselenium derivatives with an ester substituent in the ortho position. The obtained derivatives were tested as antioxidants and anticancer agents to see the influence of an ester functionality on the bioactivity of β-carbonyl selenides by replacing the o-amide group with an o-ester group. The best results as an antioxidant agent were observed for O-((1R,2S,5R)-(−)-2-isopropyl-5-methylcyclohexyl)-2-((2-oxopropyl)selanyl)benzoate. The most cytotoxic derivative against breast cancer MCF-7 cell lines was O-(methyl)-2-((2-oxopropyl)selanyl)benzoate and against human promyelocytic leukemia HL-60 was O-(2-pentyl)-2-((2-oxopropyl)selanyl)benzoate.

BackgroundProducts containing cannabidiol (CBD) are attracting attention because of their potential therapeutic benefits and positive impacts on well-being and mental health. Although additional research is needed to understand their effectiveness in treating mental disorders, cross-sectional studies may help identify the factors influencing CBD use patterns. This study examined the impact of variables such as health status, medication use, medical supervision, gender, age, and cannabis use on CBD consumption patterns.Materials and methodsA self-selected sample (n =267) of current or former CBD users was recruited via social media and participated in an online survey designed to collect data on basic demographics, health status, cannabis use, and CBD usage patterns.ResultsThe sample (n = 267) consisted of 68.5% women with an average age of 30.21 years, of which 25.8% reported diagnosed psychiatric disorders and 49.4% reported cannabis use. The top five reasons for using CBD were self-reported stress (65.3%), sleep problems (51.7%), overall improvement in well-being (52.5%), improved mood (44.9%), and anxiety relief (40.9%). Our findings suggest that individuals with psychiatric disorders and those taking psychotropic medications are more likely to use CBD to relieve stress and anxiety. Overall, nearly 70% of the individuals found CBD products to be effective. Sublingual administration was more popular among non-cannabis users, while cannabis users preferred smoking and vaping to CBD administration.ConclusionOur results indicate that individuals using CBD for health and wellness reasons believe that it has potential health benefits. Further research using rigorous longitudinal designs is needed to delve deeper into the effectiveness of low-dose CBD and to better understand the therapeutic potential of CBD.

Na przykładzie dwóch wydarzeń historycznych: śpiewającej rewolucji z 1988 r. oraz protestów przeciw sfałszowanym wyborom w Białorusi z lat 2020–2021, artykuł prezentuje sposób wykorzystania zbiorowego śpiewu do celów społeczno-politycznych. Jednym z nich jest budowanie/wzmacnianie tożsamości narodowej, drugim wyrażenie żądania zmian. Mechanizmy wykorzystywane do osiągnięcia pożądanego efektu zawarte są w tradycyjnych funkcjach pieśni.

Przedmiotem rozważań jest postrzeganie wartości zabytków sakralnych z różnych perspektyw nauk społecznych, ze szczególnym uwzględnieniem ekonomii, socjologii oraz psychologii i filozofii. Celem artykułu jest przedstawienie możliwych sposobów postrzegania wartości zabytków sakralnych oraz podkreślenie, że o ich wymiarze decydują również aspekty subiektywne. Zamiarem szczegółowym publikacji jest ocena znaczenia wartości zabytków sakralnych dla interesariuszy w korelacji z Analizą Wartościowania Zabytków Waltera Frodela, stosowaną w konserwacji (nauki o sztuce). Opracowanie ma charakter przeglądowy i zostało przygotowane na podstawie przeglądu literatury oraz wyników własnych badań empirycznych (pilotażowych) autorów. Do kwerendy wykorzystano test ANOVA Kruskala-Wallisa oraz test niezależności chi-kwadrat Pearsona. Brak legalnej definicji zabytków sakralnych spowodował, że zaproponowano autorską definicję. Analiza wykazała, że największą wartością dla respondentów jest wartość historyczna zabytków sakralnych, a najniższą wartość techniczna. Mieszkający w mieście częściej wskazywali na konsumpcjonizm jako cechę obniżającą wartość i znaczenie zabytków sakralnych.

In the present work, we report a synthesis procedure for the preparation of vertically aligned mesoporous silica thin films containing long, nanometer-scale thin silver nanowires inside pores. The inter-channel nanowires had a fine crystalline structure and a diameter of no more than 2 nm. Despite the diameter being the edge of the theoretical possibility of synthesis, the nanowires were stable enough to be observed by transmission electron microscope and could be clearly observed. For the synthesis, we applied the idea of silica nanoreactors, and the procedure consists of two steps: fabrication of an initial organically-functionalized silica thin film containing silver ions distributed regularly inside vertically aligned pores and following thermal decomposition resulting in the decomposition of the organic anchoring groups and the formation of metallic crystalline nanowires from released silver atoms. Both the final nanocomposite and the initial material were studied by means of transition electron microscopy and electrochemical techniques: linear scan and differential pulse anodic stripping voltammetry. The crystallinity of silver nanowires inside silica mesopores was proved by electron diffraction. The spatial confinement realized by silica nanochannels facilitated the stabilization of relatively small and ultra-thin nanowires and the formation of a hexagonal P63/mmc silver crystalline structure instead of the more common Fm3m cubic.

Cel/hipoteza: W ostatnich latach zauważalny jest dynamiczny rozwój urządzeń mikromobilnych, przeznaczonych do transportu osób. Tego rodzaju pojazdy określa się mianem urządzeń transportu osobistego (UTO). Jak każdy pojazd drogowy, także i UTO mogą powodować liczne wypadki i kolizje. Naturalną konsekwencją szkodowości związanej z wykorzystaniem UTO jest postawienie pytania o zabezpieczenie interesów poszkodowanych. Mając powyższe na uwadze za cel niniejszego opracowania przyjęto przybliżenie roli ubezpieczeń od odpowiedzialności cywilnej użytkowników urządzeń transportu osobistego w kontekście szkodowości związanej z użytkowaniem tego rodzaju pojazdów oraz krótką charakterystyką dostępnych na rynku produktów ubezpieczeniowych. W pracy postawiono tezę: mimo iż przepisy nie zobowiązują kierujących UTO do posiadania polisy komunikacyjnej OC, szeroki katalog niekorzystnych zdarzeń związanych z użytkowaniem urządzeń transportu odpowiednio wymaga upowszechnienia ochrony ubezpieczeniowej użytkowników tego rodzaju pojazdów. W polu ochrony ubezpieczeniowej powinni się znaleźć: użytkownicy, wypożyczający sprzęt, sprzedawcy, operatorzy a także gospodarstwa domowe. Metodyka: Opracowanie ma charakter teoretyczno-analityczny. Obok przeglądu dostępnej literatury przeanalizowano również dostępną na rynku ofertę dobrowolnych ubezpieczeń adresowanych do użytkowników UTO. Wnioski z badań: Ubezpieczenie dedykowane posiadaczom urządzeń transportu osobistego jest stosunkowo nowym produktem na rynku i jeszcze niewiele towarzystw ubezpieczeniowych posiada je w swojej ofercie. Użytkownicy urządzeń transportu osobistego mogą korzystać z posiadanych ubezpieczeń odpowiedzialności cywilnej w życiu prywatnym, zawieranych głównie przy ubezpieczeniach domów i mieszkań, stanowiącym zabezpieczenie na wypadek wyrządzenia szkody osobom trzecim. Jednym z rozwiązań prowadzących do upowszechnienia ochrony ubezpieczeniowej mogłaby być propozycja ubezpieczeń dostosowanych do rodzaju ryzyka oraz krótkiego charakteru użytkowania sprzętu (np. ubezpieczeń na czas przejazdu).

Celem niniejszego artykułu jest określenie rozumienia i istoty globalnej etyki mediów w ujęciu czołowego na świecie jej inicjatora i popularyzatora – Stephena J.A. Warda. Artykuł ten stanowi zatem próbę odpowiedzi na następujące pytania: Jak jest rozumiana globalna etyka mediów przez Warda? Dlaczego w jego przekonaniu jest ona tak bardzo potrzebna? Jak przedstawia się stan badań na temat globalnej etyki mediów w działalności badawczej Warda? Kto spośród badaczy – oprócz Warda – podejmuje niniejszą tematykę? Aby zrealizować podstawowe założenia metodologiczne, posłużono się metodami analizy treści oraz systematycznego przeglądu literatury. Materiał badawczy służący określeniu teorii globalnej etyki mediów Warda stanowią publikacje naukowe tegoż badacza. The Idea of Global Media Ethics as Approached by Stephen J. A. Ward The aim of this article is to define the understanding of global media ethics in terms of its initiator and the world’s leading populariser – Stephen J.A. Ward. This article is therefore an attempt to answer the following questions: How is global media ethics understood by Stephen J.A. Ward? Why is it so necessary from his scientific perspective? What is the state of research on global media ethics in the research activities of Stephen J.A. Ward? Who among the researchers – apart from Ward – undertakes this topic? In order to implement the basic methodological assumptions, the methods of content analysis and systematic litera-ture review were used. The research material – to define the theory of global media ethics by Stephen J.A. Ward – consists of the scientific publications of Stephen J.A. Ward.

Piktel E, Markiewicz KH, Wilczewska AZ, et al. Int J Nanomedicine. 2020;15:4573–4589. It has been brought to the authors attention that Figure 6E showing nanosystem-mediated DNA fragmentation in DLD-1 colorectal cancer cells is a duplicate of part of Figure 3C that was previously published in the review article: Wnorowska U, Fiedoruk K, Piktel E, et al. J Nanobiotechnology. 2020;18(1):3 (https://doi.org/10.1186/s12951-019-0566-z). In addition, both Figures 5E and 6E were described with incorrect treatment conditions. Data obtained during corresponding experiments were verified; consequently, Figure 5E and 6E were updated using data from the original study. The correct Figure 5 is as follows. Figure 5 Continued. Figure 5 Anticancer activity of ceragenin CSA-131 and ceragenin-containing nanoformulations against lung carcinoma A549 cells. Increase of intracellular levels of reduced thiols in A549 cells treated with CSA-131 (grey bar), MNP@CSA-131 (red bar), CSA-131+MNP (blue bar) and MNP (yellow bar) when compared to untreated control (0 μg/mL; black bar) (A). The percentages of dead cells (black columns), PI-negative cells with low viability (dark grey columns) and healthy cells (light grey columns) in lung carcinoma cells treated with CSA-131, MNP@CSA-131, CSA-131 and MNP or naked MNPs (B). The proliferation of cancer cells treated with CSA-131 (grey squares), MNP@CSA-131 (red circles), CSA-131 + MNP (blue diamonds) and MNP (yellow inverted triangles) when compared to untreated control (black squares) estimated using resazurin-based fluorimetric method (C). Induction of apoptosis in A549 cells by CSA-131 and its magnetic derivatives (D). Percentage of early apoptotic (black columns), late apoptotic/dead cells (dark grey columns) and dead cells (light grey columns). For the purpose of the clarity of the presented data, live cells (Annexin V-negative and 7-AAD-negative) were not presented in the provided figures. Morphological alternations in nuclei of A549 cells upon treatment with CSA-131, MNP@CSA-131 and CSA-131 + MNP when compared to uncreated cells (E). White arrows indicate treatment-induced morphological changes in nuclei of treated cells. All experiments were performed using agents at a concentration of 10 μg/mL for 24 h. (A–D) demonstrate results from 3 to 6 individual experiments ± SD, for panel E results from one representative experiment are shown. * and ^ indicate statistical significance (p-value

The purpose of this study is to outline the current problems with the company's documentation workflow process and propose a plan to implement a new automated system to eliminate waste and improve the company's cash flow. Every enterprise is required to accurately record business operations. Accounting is the foundation of an organization, serving not only to meet legal requirements, but also to support management processes. In the case of large enterprises, complex accounting carries the risk of problems with timely and correct accounting, which can lead to delays in payments, reminders, collection procedures and interruptions in deliveries. As a result, it becomes crucial to put processes in place to safeguard liquidity. The study includes an analysis of the company's current documentation workflow process and identification of problems associated with it. A plan is then proposed to implement a new automated system to eliminate waste. The methodology is based on an analysis of the company's internal data and available technological solutions. The main results of the study include the identification of existing problems in the documentation workflow process and a plan for implementing a new system. The findings indicate that improving process efficiency can help increase the company's cash flow. The study introduces a new perspective on records management in enterprises, especially in the context of eliminating waste and improving liquidity. The theoretical value of the work lies in identifying opportunities for effective records management in the context of supporting business processes. The introduction of an automated documentation workflow system can bring practical benefits, such as reducing payment delays, avoiding debt collection procedures and improving the overall efficiency of business operations.