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4. The triennial International Pigment Cell Conference (IPCC)

Author

Box, Neil F., Larue, Lionel, Manga, Prashiela, Montoliu, Lluis, Spritz, Richard A., and Filipp, Fabian V.

Subjects
Quantitative Biology - Other Quantitative Biology, Quantitative Biology - Tissues and Organs
Abstract

The International Federation of Pigment Cell Societies (IFPCS) held its XXIII triennial International Pigment Cell Conference (IPCC) in Denver, Colorado in August 2017. The goal of the summit was to provide a venue promoting a vibrant interchange among leading basic and clinical researchers working on leading-edge aspects of melanocyte biology and disease. The philosophy of the meeting, entitled Breakthroughs in Pigment Cell and Melanoma Research, was to deliver a comprehensive program in an inclusive environment fostering scientific exchange and building new academic bridges. This document provides an outlook on the history, accomplishments, and sustainability of the pigment cell and melanoma research community. Shared progress in the understanding of cellular homeostasis of pigment cells but also clinical successes and hurdles in the treatment of melanoma and dermatological disorders continue to drive future research activities. A sustainable direction of the societies creates an international forum identifying key areas of imminent needs in laboratory research and clinical care and ensures the future of this vibrant, diverse and unique research community at the same time. Important advances showcase wealth and breadth of the field in melanocyte and melanoma research and include emerging frontiers in melanoma immunotherapy, medical and surgical oncology, dermatology, vitiligo, albinism, genomics and systems biology, precision bench-to-bedside approaches, epidemiology, pigment biophysics and chemistry, and evolution. This report recapitulates highlights of the federate meeting agenda designed to advance clinical and basic research frontiers from melanoma and dermatological sciences followed by a historical perspective of the associated societies and conferences.

Published
2018

5. Frontiers in Pigment Cell and Melanoma Research

Author

Filipp, Fabian V., Birlea, Stanca, Bosenberg, Marcus W., Brash, Douglas, Cassidy, Pamela B., Chen, Suzie, D'Orazio, John August, Fujita, Mayumi, Goh, Boon-Kee, Herlyn, Meenhard, Indra, Arup K., Larue, Lionel, Leachman, Sancy A., Poole, Caroline Le, Liu-Smith, Feng, Manga, Prashiela, Montoliu, Lluis, Norris, David A., Shellman, Yiqun, Smalley, Keiran S. M., Spritz, Richard A., Sturm, Richard A., Swetter, Susan M., Terzian, Tamara, Wakamatsu, Kazumasa, Weber, Jeffrey S., and Box, Neil F.

Subjects
Quantitative Biology - Tissues and Organs
Abstract

We identify emerging frontiers in clinical and basic research of melanocyte biology and its associated biomedical disciplines. We describe challenges and opportunities in clinical and basic research of normal and diseased melanocytes that impact current approaches to research in melanoma and the dermatological sciences. We focus on four themes: (1) clinical melanoma research, (2) basic melanoma research, (3) clinical dermatology, and (4) basic pigment cell research, with the goal of outlining current highlights, challenges, and frontiers associated with pigmentation and melanocyte biology. Significantly, this document encapsulates important advances in melanocyte and melanoma research including emerging frontiers in melanoma immunotherapy, medical and surgical oncology, dermatology, vitiligo, albinism, genomics and systems biology, epidemiology, pigment biophysics and chemistry, and evolution.

Published
2018

6. Frontiers in pigment cell and melanoma research

Author

Filipp, Fabian V, Birlea, Stanca, Bosenberg, Marcus W, Brash, Douglas, Cassidy, Pamela B, Chen, Suzie, D'Orazio, John A, Fujita, Mayumi, Goh, Boon‐Kee, Herlyn, Meenhard, Indra, Arup K, Larue, Lionel, Leachman, Sancy A, Le Poole, Caroline, Liu‐Smith, Feng, Manga, Prashiela, Montoliu, Lluis, Norris, David A, Shellman, Yiqun, Smalley, Keiran SM, Spritz, Richard A, Sturm, Richard A, Swetter, Susan M, Terzian, Tamara, Wakamatsu, Kazumasa, Weber, Jeffrey S, and Box, Neil F

Subjects
Biomedical and Clinical Sciences, Immunology, Cancer, Immunization, Clinical Research, Aetiology, 2.6 Resources and infrastructure (aetiology), Animals, Biomedical Research, Disease Models, Animal, Drug Resistance, Neoplasm, Humans, Melanocytes, Melanoma, Pigmentation, albinism, cancer prevention, dermatology, immunotherapy, International Pigment Cell Conference, melanin, melanocyte, melanoma, melasma, pigmentation, skin, UV, vitiligo, q-bio.TO, Biological Sciences, Medical and Health Sciences, Dermatology & Venereal Diseases, Biochemistry and cell biology, Genetics, Oncology and carcinogenesis
Abstract

In this perspective, we identify emerging frontiers in clinical and basic research of melanocyte biology and its associated biomedical disciplines. We describe challenges and opportunities in clinical and basic research of normal and diseased melanocytes that impact current approaches to research in melanoma and the dermatological sciences. We focus on four themes: (1) clinical melanoma research, (2) basic melanoma research, (3) clinical dermatology, and (4) basic pigment cell research, with the goal of outlining current highlights, challenges, and frontiers associated with pigmentation and melanocyte biology. Significantly, this document encapsulates important advances in melanocyte and melanoma research including emerging frontiers in melanoma immunotherapy, medical and surgical oncology, dermatology, vitiligo, albinism, genomics and systems biology, epidemiology, pigment biophysics and chemistry, and evolution.

Published
2018

9. Inherited duplications of PPP2R3B predispose to nevi and melanoma via a C21orf91-driven proliferative phenotype

Author

Polubothu, Satyamaanasa, Zecchin, Davide, Al-Olabi, Lara, Lionarons, Daniël A., Harland, Mark, Horswell, Stuart, Thomas, Anna C., Hunt, Lilian, Wlodarchak, Nathan, Aguilera, Paula, Brand, Sarah, Bryant, Dale, Carrera, Cristina, Chen, Hui, Elgar, Greg, Harwood, Catherine A., Howell, Michael, Larue, Lionel, Loughlin, Sam, MacDonald, Jeff, Malvehy, Josep, Barberan, Sara Martin, da Silva, Vanessa Martins, Molina, Miriam, Morrogh, Deborah, Moulding, Dale, Nsengimana, Jérémie, Pittman, Alan, Puig-Butillé, Joan-Anton, Parmar, Kiran, Sebire, Neil J., Scherer, Stephen, Stadnik, Paulina, Stanier, Philip, Tell, Gemma, Waelchli, Regula, Zarrei, Mehdi, Puig, Susana, Bataille, Véronique, Xing, Yongna, Healy, Eugene, Moore, Gudrun E., Di, Wei-Li, Newton-Bishop, Julia, Downward, Julian, and Kinsler, Veronica A.

Published
2021
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10. Skin anti-aging and wound healing effects of a passion fruit seed extract rich in piceatannol

Author

Kunsorn, Paween, Payuhakrit, Witchuda, Petit, Valerie, Larue, Lionel, Champakam, Sorraya, and Suwannalert, Prasit

Abstract

UVB radiation triggers skin photoaging by inducing excess cellular oxidants, contributing to senescence, and overproducing matrix metalloproteinase-1 (MMP-1), causing skin wrinkles. Senescence also impedes skin wound closure. Passion fruit seeds (PFS) boast abundant piceatannol (PCT), recognized for its antioxidant and anti-aging properties. To study potential of PFS extract in diminishing photoaging, accelerating wound healing, and enhancing SIRT1 production in human keratinocytes (HaCaT cells). The PFS extract was assessed for PCT using HPLC analysis. The antioxidant effects, reduced senescence-associated β-galactosidase (SA-β-gal) activity, and MMP-1 production were measured in HaCaT cells exposed to UVB using a DCFA-DA assay, SA-β-gal activity, and flow cytometry/immunofluorescent including MMP-1 mRNA expression, respectively. The effect of wound healing acceleration was evaluated, including EGFR mRNA expression. Additionally, SIRT1 enhancement was investigated using flow cytometry and immunofluorescent techniques, which also included the assessment of SIRT1 mRNA expression. The PFS extract, which is rich in PCT, effectively diminished cellular oxidants and aging. It decreased UVB-induced cellular oxidants, senescence, and MMP-1 production at both protein and mRNA levels. Moreover, the extract enhanced wound closure by boosting cell migration and increasing EGFR mRNA expression. Additionally, SIRT1 production and expression, associated with cellular rejuvenation, increased in extract-treated cells. PFS extract exhibits potential for skincare and wound healing applications, offering a natural strategy to combat skin aging effects and support tissue repair.

Published
2024
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11. STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pathway

Author

Swoboda, Alexander, Soukup, Robert, Eckel, Oliver, Kinslechner, Katharina, Wingelhofer, Bettina, Schörghofer, David, Sternberg, Christina, Pham, Ha T. T., Vallianou, Maria, Horvath, Jaqueline, Stoiber, Dagmar, Kenner, Lukas, Larue, Lionel, Poli, Valeria, Beermann, Friedrich, Yokota, Takashi, Kubicek, Stefan, Krausgruber, Thomas, Rendeiro, André F., Bock, Christoph, Zenz, Rainer, Kovacic, Boris, Aberger, Fritz, Hengstschläger, Markus, Petzelbauer, Peter, Mikula, Mario, and Moriggl, Richard

Published
2021
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12. Animal Models of Melanoma

Author

Aktary, Zackie, McMahon, Martin, Larue, Lionel, Fisher, David E., Section editor, Hayward, Nick, Section editor, Whiteman, David C., Section editor, Flaherty, Keith T., Section editor, Hodi, F. Stephen, Section editor, Tsao, Hensin, Section editor, Merlino, Glenn, Section editor, Fisher, David E., editor, and Bastian, Boris C., editor

Published
2019
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15. Correction to: Thymine DNA glycosylase as a novel target for melanoma

Author

Mancuso, Pietro, Tricarico, Rossella, Bhattacharjee, Vikram, Cosentino, Laura, Kadariya, Yuwaraj, Jelinek, Jaroslav, Nicolas, Emmanuelle, Einarson, Margret, Beeharry, Neil, Devarajan, Karthik, Katz, Richard A., Dorjsuren, Dorjbal G., Sun, Hongmao, Simeonov, Anton, Giordano, Antonio, Testa, Joseph R., Davidson, Guillaume, Davidson, Irwin, Larue, Lionel, Sobol, Robert W., Yen, Timothy J., and Bellacosa, Alfonso

Published
2022
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16. BRN2 is a non-canonical melanoma tumor-suppressor

Author

Hamm, Michael, Sohier, Pierre, Petit, Valérie, Raymond, Jérémy H., Delmas, Véronique, Le Coz, Madeleine, Gesbert, Franck, Kenny, Colin, Aktary, Zackie, Pouteaux, Marie, Rambow, Florian, Sarasin, Alain, Charoenchon, Nisamanee, Bellacosa, Alfonso, Sanchez-del-Campo, Luis, Mosteo, Laura, Lauss, Martin, Meijer, Dies, Steingrimsson, Eirikur, Jönsson, Göran B., Cornell, Robert A., Davidson, Irwin, Goding, Colin R., and Larue, Lionel

Published
2021
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19. A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity.

Author

Conde-Perez, Alejandro, Gros, Gwendoline, Longvert, Christine, Pedersen, Malin, Petit, Valérie, Aktary, Zackie, Viros, Amaya, Gesbert, Franck, Delmas, Véronique, Rambow, Florian, Bastian, Boris C, Campbell, Andrew D, Colombo, Sophie, Puig, Isabel, Bellacosa, Alfonso, Sansom, Owen, Marais, Richard, Van Kempen, Leon CLT, and Larue, Lionel

Subjects
Cell Line, Tumor, Melanocytes, Animals, Mice, Transgenic, Humans, Mice, Melanoma, Skin Neoplasms, GTP Phosphohydrolases, Glycogen Synthase Kinase 3, Cadherins, Membrane Proteins, MicroRNAs, Microscopy, Fluorescence, Blotting, Western, Prognosis, Immunohistochemistry, Proto-Oncogene Proteins c-akt, PTEN Phosphohydrolase, beta Catenin, Caveolin 1, Transcriptional Activation, Feedback, Physiological, Phosphatidylinositol 3-Kinases, Glycogen Synthase Kinase 3 beta, Cell Line, Tumor, Transgenic, Microscopy, Fluorescence, Blotting, Western, Feedback, Physiological
Abstract

Loss of the tumour suppressor PTEN is frequent in human melanoma, results in MAPK activation, suppresses senescence and mediates metastatic behaviour. How PTEN loss mediates these effects is unknown. Here we show that loss of PTEN in epithelial and melanocytic cell lines induces the nuclear localization and transcriptional activation of β-catenin independent of the PI3K-AKT-GSK3β axis. The absence of PTEN leads to caveolin-1 (CAV1)-dependent β-catenin transcriptional modulation in vitro, cooperates with NRAS(Q61K) to initiate melanomagenesis in vivo and induces efficient metastasis formation associated with E-cadherin internalization. The CAV1-β-catenin axis is mediated by a feedback loop in which β-catenin represses transcription of miR-199a-5p and miR-203, which suppress the levels of CAV1 mRNA in melanoma cells. These data reveal a mechanism by which loss of PTEN increases CAV1-mediated dissociation of β-catenin from membranous E-cadherin, which may promote senescence bypass and metastasis.

Published
2015

22. Angiotropism, Pericytic Mimicry and Extravascular Migratory Metastasis in Melanoma: An Alternative to Intravascular Cancer Dissemination

Author

Lugassy, Claire, Zadran, Sohila, Bentolila, Laurent A, Wadehra, Madhuri, Prakash, Roshini, Carmichael, S Thomas, Kleinman, Hynda K, Péault, Bruno, Larue, Lionel, and Barnhill, Raymond L

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Cancer, 2.1 Biological and endogenous factors, Aetiology, Angiotropism, Melanoma, Pericyticmimicry, Extravascularmigratory metastasis, Abluminal vascular surface, Neural crest cellmigration, Vasculogenesis and angiogenesis, Laminin, Epithelial mesenchymal transition, Stem cell, Pericytic recruitment, Inflammation, Medical Biochemistry and Metabolomics, Oncology & Carcinogenesis, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

For more than 15 years, angiotropism in melanoma has been emphasized as a marker of extravascular migration of tumor cells along the abluminal vascular surface, unveiling an alternative mechanism of tumor spread distinct from intravascular dissemination. This mechanism has been termed extravascular migratory metastasis (EVMM). During EVMM, angiotropic tumor cells migrate in a 'pericytic-like' manner (pericytic mimicry) along the external surfaces of vascular channels, without intravasation. Through this pathway, melanoma cells may spread to nearby or more distant sites. Angiotropism is a prognostic factor predicting risk for metastasis in human melanoma, and a marker of EVMM in several experimental models. Importantly, analogies of EVMM and pericytic mimicry include neural crest cell migration, vasculogenesis and angiogenesis, and recent studies have suggested that the interaction between melanoma cells and the abluminal vascular surface induce differential expression of genes reminiscent of cancer migration and embryonic/stem cell state transitions. A recent work revealed that repetitive UV exposure of primary cutaneous melanomas in a genetically engineered mouse model promotes metastatic progression via angiotropism and migration along the abluminal vascular surface. Finally, recent data using imaging of melanoma cells in a murine model have shown the progression of tumor cells along the vascular surfaces. Taken together, these data provide support for the biological phenomenon of angiotropism and EVMM, which may open promising new strategies for reducing or preventing melanoma metastasis.

Published
2014

24. Novel mechanisms of MITF regulation and melanoma predisposition identified in a mouse suppressor screen

Author

Vu, Hong Nhung, primary, Valdimarsson, Matti Már, additional, Sigurbjörnsdóttir, Sara, additional, Bergsteinsdóttir, Kristín, additional, Debbache, Julien, additional, Bismuth, Keren, additional, Swing, Deborah A., additional, Hallsson, Jón H., additional, Larue, Lionel, additional, Arnheiter, Heinz, additional, Copeland, Neal G., additional, Jenkins, Nancy A., additional, Heidarsson, Petur O., additional, and Steingrímsson, Eiríkur, additional

Published
2023
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25. Thymine DNA glycosylase as a novel target for melanoma

Author

Mancuso, Pietro, Tricarico, Rossella, Bhattacharjee, Vikram, Cosentino, Laura, Kadariya, Yuwaraj, Jelinek, Jaroslav, Nicolas, Emmanuelle, Einarson, Margret, Beeharry, Neil, Devarajan, Karthik, Katz, Richard A., Dorjsuren, Dorjbal G., Sun, Hongmao, Simeonov, Anton, Giordano, Antonio, Testa, Joseph R., Davidson, Guillaume, Davidson, Irwin, Larue, Lionel, Sobol, Robert W., Yen, Timothy J., and Bellacosa, Alfonso

Published
2019
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32. MITF has a central role in regulating starvation-induced autophagy in melanoma

Author

Möller, Katrin, Sigurbjornsdottir, Sara, Arnthorsson, Asgeir O., Pogenberg, Vivian, Dilshat, Ramile, Fock, Valerie, Brynjolfsdottir, Solveig H., Bindesboll, Christian, Bessadottir, Margret, Ogmundsdottir, Helga M., Simonsen, Anne, Larue, Lionel, Wilmanns, Matthias, Thorsson, Vesteinn, Steingrimsson, Eirikur, and Ogmundsdottir, Margret H.

Published
2019
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33. Suppl Table S2 from TET2-Dependent Hydroxymethylome Plasticity Reduces Melanoma Initiation and Progression

Author

Bonvin, Elise, primary, Radaelli, Enrico, primary, Bizet, Martin, primary, Luciani, Flavie, primary, Calonne, Emilie, primary, Putmans, Pascale, primary, Nittner, David, primary, Singh, Nitesh Kumar, primary, Santagostino, Sara Francesca, primary, Petit, Valérie, primary, Larue, Lionel, primary, Marine, Jean Christophe, primary, and Fuks, François, primary

Published
2023
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34. Legend of supplementary data from TET2-Dependent Hydroxymethylome Plasticity Reduces Melanoma Initiation and Progression

Author

Bonvin, Elise, primary, Radaelli, Enrico, primary, Bizet, Martin, primary, Luciani, Flavie, primary, Calonne, Emilie, primary, Putmans, Pascale, primary, Nittner, David, primary, Singh, Nitesh Kumar, primary, Santagostino, Sara Francesca, primary, Petit, Valérie, primary, Larue, Lionel, primary, Marine, Jean Christophe, primary, and Fuks, François, primary

Published
2023
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35. Table S1 from TET2-Dependent Hydroxymethylome Plasticity Reduces Melanoma Initiation and Progression

Author

Bonvin, Elise, primary, Radaelli, Enrico, primary, Bizet, Martin, primary, Luciani, Flavie, primary, Calonne, Emilie, primary, Putmans, Pascale, primary, Nittner, David, primary, Singh, Nitesh Kumar, primary, Santagostino, Sara Francesca, primary, Petit, Valérie, primary, Larue, Lionel, primary, Marine, Jean Christophe, primary, and Fuks, François, primary

Published
2023
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36. Supplementary Tables 1-7 from Netrin-1 and Its Receptor DCC Are Causally Implicated in Melanoma Progression

Author

Boussouar, Amina, primary, Tortereau, Antonin, primary, Manceau, Ambroise, primary, Paradisi, Andrea, primary, Gadot, Nicolas, primary, Vial, Jonathan, primary, Neves, David, primary, Larue, Lionel, primary, Battistella, Maxime, primary, Leboeuf, Christophe, primary, Lebbé, Celeste, primary, Janin, Anne, primary, and Mehlen, Patrick, primary

Published
2023
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37. Supplementary Figures 1-5 from Netrin-1 and Its Receptor DCC Are Causally Implicated in Melanoma Progression

Author

Boussouar, Amina, primary, Tortereau, Antonin, primary, Manceau, Ambroise, primary, Paradisi, Andrea, primary, Gadot, Nicolas, primary, Vial, Jonathan, primary, Neves, David, primary, Larue, Lionel, primary, Battistella, Maxime, primary, Leboeuf, Christophe, primary, Lebbé, Celeste, primary, Janin, Anne, primary, and Mehlen, Patrick, primary

Published
2023
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39. Supplementary Figures from TET2-Dependent Hydroxymethylome Plasticity Reduces Melanoma Initiation and Progression

Author

Bonvin, Elise, primary, Radaelli, Enrico, primary, Bizet, Martin, primary, Luciani, Flavie, primary, Calonne, Emilie, primary, Putmans, Pascale, primary, Nittner, David, primary, Singh, Nitesh Kumar, primary, Santagostino, Sara Francesca, primary, Petit, Valérie, primary, Larue, Lionel, primary, Marine, Jean Christophe, primary, and Fuks, François, primary

Published
2023
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40. Data from TET2-Dependent Hydroxymethylome Plasticity Reduces Melanoma Initiation and Progression

Author

Bonvin, Elise, primary, Radaelli, Enrico, primary, Bizet, Martin, primary, Luciani, Flavie, primary, Calonne, Emilie, primary, Putmans, Pascale, primary, Nittner, David, primary, Singh, Nitesh Kumar, primary, Santagostino, Sara Francesca, primary, Petit, Valérie, primary, Larue, Lionel, primary, Marine, Jean Christophe, primary, and Fuks, François, primary

Published
2023
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41. Supplementary Data from Small-Molecule Drugs Mimicking DNA Damage: A New Strategy for Sensitizing Tumors to Radiotherapy

Author

Quanz, Maria, primary, Berthault, Nathalie, primary, Roulin, Christophe, primary, Roy, Maryline, primary, Herbette, Aurélie, primary, Agrario, Céline, primary, Alberti, Christophe, primary, Josserand, Véronique, primary, Coll, Jean-Luc, primary, Sastre-Garau, Xavier, primary, Cosset, Jean-Marc, primary, Larue, Lionel, primary, Sun, Jian-Sheng, primary, and Dutreix, Marie, primary

Published
2023
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