8 results on '"Larsson, H. J."'
Search Results
2. International comparison of treatment strategy and survival in metastatic gastric cancer
- Author
-
Claassen, Y. H. M., Bastiaannet, E., Hartgrink, H. H., Dikken, J. L., de Steur, W. O., Slingerland, M., Verhoeven, R. H. A., van Eycken, E., de Schutter, H., Lindblad, M., Hedberg, Jakob, Johnson, E., Hjortland, G. O., Jensen, L. S., Larsson, H. J., Koessler, T., Chevallay, M., Allum, W. H., van de Velde, C. J. H., Claassen, Y. H. M., Bastiaannet, E., Hartgrink, H. H., Dikken, J. L., de Steur, W. O., Slingerland, M., Verhoeven, R. H. A., van Eycken, E., de Schutter, H., Lindblad, M., Hedberg, Jakob, Johnson, E., Hjortland, G. O., Jensen, L. S., Larsson, H. J., Koessler, T., Chevallay, M., Allum, W. H., and van de Velde, C. J. H.
- Abstract
BackgroundIn the randomized Asian REGATTA trial, no survival benefit was shown for additional gastrectomy over chemotherapy alone in patients with advanced gastric cancer with a single incurable factor, thereby discouraging surgery for these patients. The purpose of this study was to evaluate treatment strategies for patients with metastatic gastric cancer in daily practice in five European countries, along with relative survival in each country. MethodsNationwide population-based data from Belgium, Denmark, the Netherlands, Norway and Sweden were combined. Patients with primary metastatic gastric cancer diagnosed between 2006 and 2014 were included. The proportion of gastric resections performed and the administration of chemotherapy (irrespective of surgery) within each country were determined. Relative survival according to country was calculated. ResultsOverall, 15 057 patients with gastric cancer were included. The proportion of gastric resections varied from 81 per cent in the Netherlands and Denmark to 183 per cent in Belgium. Administration of chemotherapy was 392 per cent in the Netherlands, compared with 632 per cent in Belgium. The 6-month relative survival rate was between 390 (95 per cent c.i. 378 to 402) per cent in the Netherlands and 541 (521 to 569) per cent in Belgium. ConclusionThere is variation in the use of gastrectomy and chemotherapy in patients with metastatic gastric cancer, and subsequent differences in survival.
- Published
- 2019
- Full Text
- View/download PDF
3. International comparison of treatment strategy and survival in metastatic gastric cancer
- Author
-
Claassen, Y. H. M., primary, Bastiaannet, E., additional, Hartgrink, H. H., additional, Dikken, J. L., additional, de Steur, W. O., additional, Slingerland, M., additional, Verhoeven, R. H. A., additional, van Eycken, E., additional, de Schutter, H., additional, Lindblad, M., additional, Hedberg, J., additional, Johnson, E., additional, Hjortland, G. O., additional, Jensen, L. S., additional, Larsson, H. J., additional, Koessler, T., additional, Chevallay, M., additional, Allum, W. H., additional, and van de Velde, C. J. H., additional
- Published
- 2018
- Full Text
- View/download PDF
4. Quality-of-care initiative in patients treated surgically for perforated peptic ulcer.
- Author
-
Møller, M. H., Larsson, H. J., Rosenstock, S., Jørgensen, H., Johnsen, S. P., Madsen, A. H., Adamsen, S., Jensen, A. G., Zimmermann‐Nielsen, E., and Thomsen, R. W.
- Subjects
- *
PEPTIC ulcer , *MEDICAL quality control , *ACQUISITION of data , *BODY weight , *CONFIDENCE intervals , *PATIENTS ,PEPTIC ulcer surgery - Abstract
Background: Mortality and morbidity are considerable after treatment for perforated peptic ulcer (PPU). Since 2003, a Danish nationwide quality-of-care (QOC) improvement initiative has focused on reducing preoperative delay, and improving perioperative monitoring and care for patients with PPU. The present study reports the results of this initiative. Methods: This was a nationwide cohort study based on prospectively collected data, involving all hospitals caring for patients with PPU in Denmark. Details of patients treated surgically for PPU between September 2004 and August 2011 were reported to the Danish Clinical Register of Emergency Surgery. Changes in baseline patient characteristics and in seven QOC indicators are presented, including relative risks (RRs) for achievement of the indicators. Results: The study included 2989 patients. An increasing number fulfilled the following four QOC indicators in 2010-2011 compared with the first 2 years of monitoring: preoperative delay no more than 6 h (59·0 versus 54·0 per cent; P = 0·030), daily monitoring of bodyweight (48·0 versus 29·0 per cent; P < 0·001), daily monitoring of fluid balance (79·0 versus 74·0 per cent; P = 0·010) and daily monitoring of vital signs (80·0 versus 68·0 per cent; P < 0·001). A lower proportion of patients had discontinuation of routine prophylactic antibiotics (82·0 versus 90·0 per cent; P < 0·001). Adjusted 30-day mortality decreased non-significantly from 2005-2006 to 2010-2011 (adjusted RR 0·87, 95 per cent confidence interval 0·76 to 1·00), whereas the rate of reoperative surgery remained unchanged (adjusted RR 0·98, 0·78 to 1·23). Conclusion: This nationwide quality improvement initiative was associated with reduced preoperative delay and improved perioperative monitoring in patients with PPU. A non-significant improvement was seen in 30-day mortality. Copyright © 2012 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
5. Axial Rotation of Orion Stars of Spectral Type B0-B3.
- Author
-
McNamara, D. H., primary and Larsson, H. J., additional
- Published
- 1962
- Full Text
- View/download PDF
6. Perinatal environmental factors and parental pyschopathology were associated with risk of autism in Danish children.
- Author
-
Larsson, H. J., Eaton, W. W., and Madsen, K. M.
- Subjects
- *
DEVELOPMENTAL disabilities , *AUTISM , *PSYCHIATRIC diagnosis , *CHILDREN with disabilities , *PATHOLOGICAL psychology , *PSYCHIATRY - Abstract
The article focuses on risk factors for autism, perinatal factors, parental psychiatric history and socioeconomic status. Children were discharged from a Danish psychiatric hospital with a diagnosis of infantile or atypical autism. Perinatal risk factors defined as present if a psychiatric diagnosis in the child had been recorded before the date autism was diagnosed in the child and socioeconomic status. Perinatal environmental risk factors and parental psychiatric history were associated with subsequent development of autism.
- Published
- 2005
7. North European comparison of treatment strategy and survival in older patients with resectable gastric cancer: A EURECCA upper gastrointestinal group analysis.
- Author
-
Claassen YHM, Dikken JL, Hartgrink HH, de Steur WO, Slingerland M, Verhoeven RHA, van Eycken E, de Schutter H, Johansson J, Rouvelas I, Johnson E, Hjortland GO, Jensen LS, Larsson HJ, Allum WH, Portielje JEA, Bastiaannet E, and van de Velde CJH
- Subjects
- Aged, Aged, 80 and over, Europe epidemiology, Female, Humans, Male, Neoplasm Grading, Neoplasm Staging, Registries, Stomach Neoplasms mortality, Stomach Neoplasms pathology, Stomach Neoplasms therapy, Survival Rate, Stomach Neoplasms surgery
- Abstract
Background: As older gastric cancer patients are often excluded from randomized clinical trials, the most appropriate treatment strategy for these patients remains unclear. The current study aimed to gain more insight in treatment strategies and relative survival of older patients with resectable gastric cancer across Europe., Methods: Population-based cohorts from Belgium, Denmark, The Netherlands, Norway, and Sweden were combined. Patients ≥70 years with resectable gastric cancer (cT1-4a, cN0-2, cM0), diagnosed between 2004 and 2014 were included. Resection rates, administration of chemotherapy (irrespective of surgery), and relative survival within a country according to stage were determined., Results: Overall, 6698 patients were included. The percentage of operated patients was highest in Belgium and lowest in Sweden for both stage II (74% versus 56%) and stage III disease (57% versus 25%). For stage III, chemotherapy administration was highest in Belgium (44%) and lowest in Sweden (2%). Three year relative survival for stage I, II, and III disease in Belgium was 67.8% (95% CI:62.8-72.6), 41.2% (95% CI:37.3-45.2), 17.8% (95% CI:12.5-24.0), compared with 56.7% (95% CI:51.5-61.7), 31.3% (95% CI:27.6-35.2), 8.2% (95% CI:4.4-13.4) in Sweden. There were no significant differences in treatment strategies of patients with stage I disease., Conclusion: Substantial treatment differences are observed across North European countries for patients with stages II and III resectable gastric cancer aged 70 years or older. In the present comparison, treatment strategies with a higher proportion of patients undergoing surgery seemed to be associated with higher survival rates for patients with stages II or III disease., (Copyright © 2018. Published by Elsevier Ltd.)
- Published
- 2018
- Full Text
- View/download PDF
8. Differences in outcomes of oesophageal and gastric cancer surgery across Europe.
- Author
-
Dikken JL, van Sandick JW, Allum WH, Johansson J, Jensen LS, Putter H, Coupland VH, Wouters MW, Lemmens VE, van de Velde CJ, van der Geest LG, Larsson HJ, Cats A, and Verheij M
- Subjects
- Aged, Carcinoma mortality, Carcinoma pathology, Carcinoma secondary, Esophageal Neoplasms mortality, Europe epidemiology, Female, Humans, Male, Middle Aged, Neoplasm Staging, Stomach Neoplasms mortality, Stomach Neoplasms pathology, Survival Rate, Treatment Outcome, Carcinoma surgery, Esophageal Neoplasms surgery, Esophagectomy mortality, Gastrectomy mortality, Stomach Neoplasms surgery
- Abstract
Background: In several European countries, centralization of oesophagogastric cancer surgery has been realized and clinical audits initiated. The present study was designed to evaluate differences in resection rates, outcomes and annual hospital volumes between these countries, and to analyse the relationship between hospital volume and outcomes., Methods: National data were obtained from cancer registries or clinical audits in the Netherlands, Sweden, Denmark and England. Differences in outcomes were analysed between countries and between hospital volume categories, adjusting for available case-mix factors., Results: Between 2004 and 2009, 10 854 oesophagectomies and 9010 gastrectomies were registered. Resection rates in England were 18·2 and 21·6 per cent for oesophageal and gastric cancer respectively, compared with 28·5-29·9 and 41·4-41·9 per cent in the Netherlands and Denmark (P < 0·001). The adjusted 30-day mortality rate after oesophagectomy was lowest in Sweden (1·9 per cent). After gastrectomy, the adjusted 30-day mortality rate was significantly higher in the Netherlands (6·9 per cent) than in Sweden (3·5 per cent; P = 0·017) and Denmark (4·3 per cent; P = 0·029). Increasing hospital volume was associated with a lower 30-day mortality rate after oesophagectomy (odds ratio 0·55 (95 per cent confidence interval 0·42 to 0·72) for at least 41 versus 1-10 procedures per year) and gastrectomy (odds ratio 0·64 (0·41 to 0·99) for at least 21 versus 1-10 procedures per year)., Conclusion: Hospitals performing larger numbers of oesophagogastric cancer resections had a lower 30-day mortality rate. Differences in outcomes between several European countries could not be explained by differences in hospital volumes. To understand these differences in outcomes and resection rates, with reliable case-mix adjustments, a uniform European upper gastrointestinal cancer audit with recording of standardized data is warranted., (Copyright © 2012 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.)
- Published
- 2013
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.