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5. Supported gel slab scaffolds as a three-dimensional cell-based assay platform.

Author

Sitte, Zachary R., Karlsson, Elizabeth E., Larson, Tyler S., Li, Haolin, Zhou, Haibo, and Lockett, Matthew R.

Subjects
CHEMICAL libraries, DRUG discovery, CONFOCAL microscopy, MONOMOLECULAR films, PHENOTYPES, LASER beam cutting
Abstract

Cell-based assays are heavily relied on in the drug discovery pipeline, quickly pairing down large compound libraries to a manageable number of drug candidates for further characterization and evaluation. Monolayer cultures in which cells are deposited onto the bottom of well plates are the workhorse of many of these screens despite continued evidence of their inability to predict in vivo responses. Three-dimensional (3D) culture platforms can generate tissue-like environments with more representative cellular phenotypes than monolayers but have proven challenging to incorporate into already-developed workflows. Scaffold-based approaches are a tractable means of generating tissue-like environments, supporting cell-laden gels whose preparation is analogous to depositing cells in a well plate. Here, we describe supported gel slab (SGS) scaffolds prepared from commercially available materials, an adhesive spray, and a laser cutter. These cell-containing scaffolds can readily fit into well plates, providing a format compatible with current liquid handlers and analytical instrumentation. The scaffolds enable the evaluation of cellular responses in individual or stacked structures, which contain extracellular matrix-rich microenvironments. With a series of demonstrations, we highlight the utility of the readily assembled SGS scaffolds to quantify cellular responses. These readouts include confocal microscopy, quantifying cellular invasion in Transwell-like and stacked formats, generating multilayered spheroid-on-demand structures capable of providing spatially resolved maps of drug responses, and identifying potential chemotherapies in a screening application. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Balancing Resilience and Equanimity: Mother Courage, Authenticity, and The Cart

Author

Larson, Tyler

Subjects
Theater
Abstract

Within the production process of Mother Courage and Her Children, I discovered parallels between the character of Mother Courage and myself. In the play, Mother Courage trudges forward with her cart, facing difficult decisions with unpredictable outcomes. She relies heavily on her ego for protection, which results in the loss of all three of her children. Mother Courage is resilient, however she lacks the ability to actively acknowledge, accept, and engage in challenging situations without falling victim to stress, self-judgement, and self-doubt. Resilience has always been one of my greatest strengths, but during the process of Mother Courage and Her Children, I observed how my own resilience can negatively impact the production process. Mother Courage and her cart symbolize self-imposed expectations, personal baggage, and the destructive qualities of ego. She is resistant to engaging with her authentic self, and lacks presence. I relied upon my resilience to weather the challenges of the process, and this behavior distanced me from my fellow collaborators. I became Mother Courage and her cart, operating solely on resilience, without its counterpart, equanimity, losing the connection to the cast, director, and stage management team. However, in the technical phase of the process, I rebuilt those connections. By detaching from my ego, accepting the situations for what they were, and engaging with my authentic self, I found the balance between my resilience and equanimity. My experience with the Mother Courage process helped me to live in the mess with equanimity, while accepting and acknowledging my own resilience.

Published
2019

15. Abstract 490: Single nucleotide variations within and around microRNA-binding sites

Author

Budmark*, Amber, primary, Catalano*, Michael, additional, Haley*, Tyrel, additional, Hicks*, Brady, additional, Koenen*, Maria, additional, Patrick*, Thea, additional, Larson*, Tyler, additional, Wagner*, Tyler, additional, Butler, Clark, additional, Feiner, Joshua, additional, Frick, Rebecca, additional, Haage, Sierra, additional, Miller, James, additional, Nohr, Mackayla, additional, Stadlman, Dillon, additional, Turner, Dillon, additional, Husher, Sara, additional, Woslum, Nicholas, additional, Stadem, Nathan, additional, Dosch, John, additional, Fortuna, Tyler, additional, Fredrich, Chandler, additional, Hadley, Elise, additional, Oehlerking, Brooklynn, additional, Paulson, Delayna, additional, Wiese, Cal, additional, Mazzer, Paula, additional, Mullican, Tim, additional, Anderson, Cynthia, additional, Larson, Mark, additional, Paryiskaya, Elena, additional, Kharazova, Alexandra, additional, Vermeer, Paola, additional, Milanovich, Samuel, additional, Savinov, Alexei, additional, Collins, John, additional, and Kofman, Alexander, additional

Published
2018
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16. Colaboradores

Author

Agrawal, Yuvraj, Aït-Si-Selmi, Tarik, Amanatullah, Derek F., Angerame, Marc R., Barnes, C. Lowry, Barry, Jeffrey J., Beaulé, Paul E., Beck, Martin, Becker, Edward H., Bedair, Hany, Berend, Keith R., Berend, Michael E., Bergmann, Georg, Bernthal, Nicholas M., Berry, Daniel J., Bingham, Joshua, Blumstein, Gideon W., Bolognesi, Michael P., Bostrom, Mathias P., Bothorel, Hugo, Box, Hayden N., Bozic, Kevin, Brown, Nicholas M., Browne, James A., Burke, Dennis W., Burke, Zachary D.C., Burnett, R. Stephen J., Byrd, J. W. Thomas, Campbell, Patricia A., Carter, Aaron, Chatelet, Jean-Christophe, Charity, John, Chen, Kevin K., Clohisy, John C., Cohen-Rosenblum, Anna R., Colwell, Clifford W., Cordry, Ryan, Couch, Cory G., Courtney, P. Maxwell, Crawford, David A., Cross, Michael B., Daines, Brian, Damm, Philipp, Valle, Craig J. Della, De Martino, Ivan, Dennis, Douglas A., Di Cesare, Paul E., Donaldson, Matthew J., Dorr, Lawrence D., Duda, Georg N., Dunbar, Michael J., Duncan, Clive, Duwelius, Paul J., Edelstein, Adam I., Edwards, Paul K., Engh, C. Anderson, Engstrom, Stephen M., Esposito, Christina, Estrera, Kenneth, Fehring, Keith, Fehring, Thomas, Ferguson, Stephen, Fessy, Michel-Henri, Ford, Marcus C., Frisch, Nicholas B., Gandhi, Rajiv, Garbuz, Donald S., Garvin, Kevin L., Geller, Jeffrey A., Gibon, Emmanuel, Gie, Graham A., Goldstein, Rachel Y., Goodman, Stuart B., Goodnough, Lawrence H., Grammatopoulos, George, Gross, Allan E., Haddad, Fares S., Haidukewych, George J., Hamadouche, Moussa, Hampton, Chadwick, Han, Shuyang, Hanke, Markus S., Hardwick, Mary E., Hartman, Curtis, Heckmann, Nathanael, Heller, Markus O.W., Horlocker, Terese T., Hornicek, Francis J., Howell, Jonathan R., Hozack, William J., Hubble, Matthew J.W., Huddleston, James I., III, Hunt, Devyani, Huo, Michael H., Iorio, Richard, Jacobs, Joshua J., Jeffers, Jonathan R.T., Jennings, Jason M., Jiranek, William A., Kadado, Allen, Kashiwagi, Deanne T., Kassam, Al-Amin M., Keating, E. Michael, Keeney, James, Keller, A. Scott, Khakharia, Saurabh, Khlopas, Anton, Kildow, Beau J., Kim, Harry K.W., Klein, Gregg R., Konigsberg, Beau S., Kopp, Sandra L., Koval, Kenneth J., Kregor, Philip J., Kurmis, Andrew, Kuzyk, Paul R., Kyle, Richard F., Lachiewicz, Paul F., Larson, Tyler J., Laurent, Michel P., Leibold, Christiane S., Leighton, Jennifer L., Lerch, Till D., Leunig, Michael, Lewallen, David G., Liporace, Frank A., Lombardi, Adolph V., Ma, Ting, Mabry, Tad M., Mahomed, Nizar, Malchau, Henrik, Maloney, William J., Mann, Kenneth, Manrique, Jorge, Mantilla, Carlos B., Marker, David R., Martin, Hal David, Mason, Thomas G., Masri, Bassam A., Mayle, Robert E., McDonald, Douglas, McGrory, Brian J., Meneghini, R. Michael, Mont, Michael A., Morris, Michael J., Nadeau, Richard P., Nassif, Nader A., Nelson, Charles, Nestor, Bryan J., Noble, Philip C., Nord, Keith M., Novais, Eduardo N., Novikov, David A., Oakes, Daniel A., Padgett, Douglas E., Pagnano, Mark W., Paprosky, Wayne G., Parry, Joshua A., Patel, Jay, Patel, Ronak M., Peck, Jeffrey B., Pellegrini, Vincent D., Perka, Carsten, Pickering, Trevor R., Pietrzak, Jurek R.T., Prather, Heidi, Rakhra, Kawan S., Reeves, Russell A., Ries, Michael D., Rimnac, Clare M., Ritting, Andrew W., Rose, Peter S., Rutherford, Richard W., Safir, Oleg A., Sandoval, Enrique, Santore, Richard, Schmaranzer, Florian, Schmidt, Andrew H., Schoenecker, Perry L., Schwab, Joseph H., Schwarzkopf, Ran, Sems, S. Andrew, Seyler, Thorsten M., Sharkey, Peter F., Sheikh, Adnan M., Sheth, Neil P., Siebenrock, Klaus A., Sierra, Rafael J., Sink, Ernest L., Sobieraj, Michael C., Southgate, Richard D., Spangehl, Mark J., Sporer, Scott M., Springer, Bryan D., Stal, Drew N., Stans, Anthony A., Stefl, Michael D., Steppacher, Simon D., Stulberg, S. David, Sucato, Daniel J., Swanson, Megan A., Takamura, Karren, Tannast, Moritz, Tanzer, Dylan, Tanzer, Michael, Taunton, Michael J., Timperley, A. John, Trasolini, Nicholas, Trousdale, Robert T., Vail, Thomas P., Vestermark, George L., Vidalain, Jean-Pierre, Walter, William L., Wasterlain, Amy S., Watts, Evan, Weber, Alexander E., Weber, Elizabeth, Whitehouse, Sarah L., Wilkin, Geoffrey P., Wilson, Matthew J., Wimmer, Markus A., Wooster, Benjamin M., Wright, Timothy M., Wyatt, Michael, Wyles, Cody C., Yingling, John M., Yoon, Richard S., Zaltz, Ira, Zierenberg, Adam, Zmugg, Stephan, and Zywiel, Michael G.

Published
2021
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17. Contributors

Author

Agrawal, Yuvraj, Aït-Si-Selmi, Tarik, Amanatullah, Derek F., Angerame, Marc R., Barnes, C. Lowry, Barry, Jeffrey J., Beaulé, Paul E., Beck, Martin, Becker, Edward H., Bedair, Hany, Berend, Keith R., Berend, Michael E., Bergmann, Georg, Bernthal, Nicholas M., Berry, Daniel J., Bingham, Joshua, Blumstein, Gideon W., Bolognesi, Michael P., Bostrom, Mathias P., Bothorel, Hugo, Box, Hayden N., Bozic, Kevin, Brown, Nicholas M., Browne, James A., Burke, Dennis W., Burke, Zachary D.C., Burnett, R. Stephen J., Byrd, J.W. Thomas, Campbell, Patricia A., Carter, Aaron, Chatelet, Jean-Christophe, Charity, John, Chen, Kevin K., Clohisy, John C., Cohen-Rosenblum, Anna R., Colwell, Clifford W., Jr., Cordry, Ryan, Couch, Cory G., Courtney, P. Maxwell, Crawford, David A., Cross, Michael B., Daines, Brian, Damm, Philipp, Della Valle, Craig J., Martino, Ivan De, Dennis, Douglas A., Di Cesare, Paul E., Donaldson, Matthew J., Dorr, Lawrence D., Duda, Georg N., Dunbar, Michael J., Duncan, Clive, Duwelius, Paul J., Edelstein, Adam I., Edwards, Paul K., Engh, C. Anderson, Jr., Engstrom, Stephen M., Esposito, Christina, Estrera, Kenneth, Fehring, Keith, Fehring, Thomas, Ferguson, Stephen, Fessy, Michel-Henri, Ford, Marcus C., Frisch, Nicholas B., Gandhi, Rajiv, Garbuz, Donald S., Garvin, Kevin L., Geller, Jeffrey A., Gibon, Emmanuel, Gie, Graham A., Goldstein, Rachel Y., Goodman, Stuart B., Goodnough, Lawrence H., Grammatopoulos, George, Gross, Allan E., Haddad, Fares S., Haidukewych, George J., Hamadouche, Moussa, Hampton, Chadwick, Han, Shuyang, Hanke, Markus S., Hardwick, Mary E., Hartman, Curtis, Heckmann, Nathanael, Heller, Markus O.W., Horlocker, Terese T., Hornicek, Francis J., Howell, Jonathan R., Hozack, William J., Hubble, Matthew J.W., Huddleston, James I., III, Hunt, Devyani, Huo, Michael H., Iorio, Richard, Jacobs, Joshua J., Jeffers, Jonathan R.T., Jennings, Jason M., Jiranek, William A., Kadado, Allen, Kashiwagi, Deanne T., Kassam, Al-Amin M., Keating, E. Michael, Keeney, James, Keller, A. Scott, Khakharia, Saurabh, Khlopas, Anton, Kildow, Beau J., Kim, Harry K.W., Klein, Gregg R., Konigsberg, Beau S., Kopp, Sandra L., Koval, Kenneth J., Kregor, Philip J., Kurmis, Andrew, Kuzyk, Paul R., Kyle, Richard F., Lachiewicz, Paul F., Larson, Tyler J., Laurent, Michel P., Leibold, Christiane S., Leighton, Jennifer L., Lerch, Till D., Leunig, Michael, Lewallen, David G., Liporace, Frank A., Lombardi, Adolph V., Jr., Ma, Ting, Mabry, Tad M., Mahomed, Nizar, Malchau, Henrik, Maloney, William J., Mann, Kenneth, Manrique, Jorge, Mantilla, Carlos B., Marker, David R., Martin, Hal David, Mason, Thomas G., Masri, Bassam A., Mayle, Robert E., Jr., McDonald, Douglas, McGrory, Brian J., Meneghini, R. Michael, Mont, Michael A., Morris, Michael J., Nadeau, Richard P., Nassif, Nader A., Nelson, Charles, Nestor, Bryan J., Noble, Philip C., Nord, Keith M., Novais, Eduardo N., Novikov, David A., Oakes, Daniel A., Padgett, Douglas E., Pagnano, Mark W., Paprosky, Wayne G., Parry, Joshua A., Patel, Jay, Patel, Ronak M., Peck, Jeffrey B., Pellegrini, Vincent D., Jr., Perka, Carsten, Pickering, Trevor R., Pietrzak, Jurek R.T., Prather, Heidi, Rakhra, Kawan S., Reeves, Russell A., Ries, Michael D., Rimnac, Clare M., Ritting, Andrew W., Rose, Peter S., Rutherford, Richard W., Safir, Oleg A., Sandoval, Enrique, Santore, Richard, Schmaranzer, Florian, Schmidt, Andrew H., Schoenecker, Perry L., Schwab, Joseph H., Schwarzkopf, Ran, Sems, S. Andrew, Seyler, Thorsten M., Sharkey, Peter F., Sheikh, Adnan M., Sheth, Neil P., Siebenrock, Klaus A., Sierra, Rafael J., Sink, Ernest L., Sobieraj, Michael C., Southgate, Richard D., Spangehl, Mark J., Sporer, Scott M., Springer, Bryan D., Stal, Drew N., Stans, Anthony A., Stefl, Michael D., Steppacher, Simon D., Stulberg, S. David, Sucato, Daniel J., Swanson, Megan A., Takamura, Karren, Tannast, Moritz, Tanzer, Dylan, Tanzer, Michael, Taunton, Michael J., Timperley, A. John, Trasolini, Nicholas, Trousdale, Robert T., Vail, Thomas P., Vestermark, George L., Vidalain, Jean-Pierre, Walter, William L., Wasterlain, Amy S., Watts, Evan, Weber, Alexander E., Weber, Elizabeth, Whitehouse, Sarah L., Wilkin, Geoffrey P., Wilson, Matthew J., Wimmer, Markus A., Wooster, Benjamin M., Wright, Timothy M., Wyatt, Michael, Wyles, Cody C., Yingling, John M., Yoon, Richard S., Zaltz, Ira, Zierenberg, Adam, Zmugg, Stephan, and Zywiel, Michael G.

Published
2020
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18. I’M A REAL BOY: IMPUTING RACIAL IDENTITY TO CORPORATIONS FOR RACIAL DISCRIMINATION STANDING.

Author

Larson, Tyler

Subjects
*RACE discrimination laws, *BURWELL v. Hobby Lobby Stores Inc., *SEARCHES & seizures (Law), *DUE process of law, CIVIL Rights Act of 1991
Abstract

The article focuses on the corporate standing theory through relevant history and policy with the corporate racial discrimination claims. Topics discussed include corporate personhood in the U.S. with the U.S. Civil Rights Act, corporations can claim racial discrimination with the U.S. Supreme Court in the case Burwell v. Hobby Lobby Stores on corporations with religious beliefs and corporations protections such as illegal search and seizures and the Due Process Clause.

Published
2016

19. 6 ACCESSORIES that make the iPhone an even BETTER VIDEO CAMERA.

Author

Larson, Tyler and Masaoka, Dan

Subjects
*CAMCORDERS, *EQUIPMENT & supplies, IPHONE equipment
Abstract

The article offers brief information on various video camera accessories for the iPhone smartphone including the Lens System, the phone tripod mount and the PocketSkater 2 camera skater from video camera equipment providers Moment Inc., RetiCam Ltd. and Edelkrone.

Published
2017

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