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Problemstilling: Formålet med dette studie er at se på, om TENS kan bruges som behandling til at reducere centrale neuropatiske smerter ved patienter med skader i centralnervesystemet (CNS) herunder rygmarvskadede, stroke og multipel sclerose. Metode: PubMed, Embase og Google Scholar søgedatabaserne blev brugt til systematisk søgning i litteraturstudiet. Effektstudier fra 1989 til 2018 med TENS, som behandlingsmetode blev inkluderet. Resultater: 8 effektstudier med TENS blev inkluderet, herunder 5 studier med rygmarvsskadede patienter, 1 studie med multipel sclerose (MS) patienter, 1 studie med stroke patienter og 1 studie med alle 3 diagnosegrupper. Effekten af TENS var signifikant i alle studierne, men effekten på VAS- skalaen (Visuel Analog Skala) varierede fra største reduktion på 3,65 til mindste reduktion på 0,51 point på skalaen. Det ser ud til effekten af TENS er størst på rygmarvsskadede patienter. Konklusion: TENS ser ud til at være effektiv i forhold til at reducere centrale neuropatiske smerter hos patienter med skader i CNS. Evidensen er dog relativ svag. Fremtidige studier skal være veldesignet med større populationer for at kunne fremvise større effekt af behandlingen. Desuden mangler der flere studier, der specifikt ser på effekten af TENS ved MS-patienter og stroke patienter. Nøgleord: Central neuropatisk smerte (CNP), Central poststroke smerte (CPSP), Transkutan Elektrisk Nervestimulering (TENS), Rygmarvskadede, Multipel Sclerose (MS), Stroke patienter., Problem: The purpose of this study is to investigate if transcutaneous electrical nerve stimulation (TENS) can be used as a treatment to reduce central neuropathic pain in patients with injuries to the central nervous system (CNS), including people suffering from spinal cord injuries, stroke or multiple sclerosis. Method: The databases PubMed, Embase and Google Scholar were used in a systematic literature review, and effect studies from 1989 to 2018 in which TENS was used as the method of treatment included. Results: 8 effect studies using TENS were used, including 5 studies of patients with spinal cord injuries, 1 of multiple sclerosis (MS) patients, 1 of stroke patients, and 1 featuring all 3 groups. The impact of TENS was significant in all the studies, but the effect on the Visual Analog Scale (VAS) varied from a highest reduction of 3.65 points on the scale to a lowest reduction of 0.51. This indicates that the effect of TENS is greatest in patients with spinal cord injuries. Conclusion: TENS seems to be efficient when it comes to reducing central neuropathic pain in patients with CNS injuries. The evidence, however, is fairly weak. Future studies must be well designed and comprise bigger populations in order to demonstrate a greater effect of the treatment. Additionally, more studies need to focus specifically on the effect of TENS in MS and stroke patients. Key words: Central neuropathic pain (CNP), central post-stroke pain (CPSP), Transcutaneous Electric Nerve Stimulation (TENS), Spinal cord injuries, Multiple Sclerosis (MS), Stroke patients.

Problemstilling: Formålet med dette studie er at se på, om TENS kan bruges som behandling til at reducere centrale neuropatiske smerter ved patienter med skader i centralnervesystemet (CNS) herunder rygmarvskadede, stroke og multipel sclerose. Metode: PubMed, Embase og Google Scholar søgedatabaserne blev brugt til systematisk søgning i litteraturstudiet. Effektstudier fra 1989 til 2018 med TENS, som behandlingsmetode blev inkluderet. Resultater: 8 effektstudier med TENS blev inkluderet, herunder 5 studier med rygmarvsskadede patienter, 1 studie med multipel sclerose (MS) patienter, 1 studie med stroke patienter og 1 studie med alle 3 diagnosegrupper. Effekten af TENS var signifikant i alle studierne, men effekten på VAS- skalaen (Visuel Analog Skala) varierede fra største reduktion på 3,65 til mindste reduktion på 0,51 point på skalaen. Det ser ud til effekten af TENS er størst på rygmarvsskadede patienter. Konklusion: TENS ser ud til at være effektiv i forhold til at reducere centrale neuropatiske smerter hos patienter med skader i CNS. Evidensen er dog relativ svag. Fremtidige studier skal være veldesignet med større populationer for at kunne fremvise større effekt af behandlingen. Desuden mangler der flere studier, der specifikt ser på effekten af TENS ved MS-patienter og stroke patienter. Nøgleord: Central neuropatisk smerte (CNP), Central poststroke smerte (CPSP), Transkutan Elektrisk Nervestimulering (TENS), Rygmarvskadede, Multipel Sclerose (MS), Stroke patienter., Problem: The purpose of this study is to investigate if transcutaneous electrical nerve stimulation (TENS) can be used as a treatment to reduce central neuropathic pain in patients with injuries to the central nervous system (CNS), including people suffering from spinal cord injuries, stroke or multiple sclerosis. Method: The databases PubMed, Embase and Google Scholar were used in a systematic literature review, and effect studies from 1989 to 2018 in which TENS was used as the method of treatment included. Results: 8 effect studies using TENS were used, including 5 studies of patients with spinal cord injuries, 1 of multiple sclerosis (MS) patients, 1 of stroke patients, and 1 featuring all 3 groups. The impact of TENS was significant in all the studies, but the effect on the Visual Analog Scale (VAS) varied from a highest reduction of 3.65 points on the scale to a lowest reduction of 0.51. This indicates that the effect of TENS is greatest in patients with spinal cord injuries. Conclusion: TENS seems to be efficient when it comes to reducing central neuropathic pain in patients with CNS injuries. The evidence, however, is fairly weak. Future studies must be well designed and comprise bigger populations in order to demonstrate a greater effect of the treatment. Additionally, more studies need to focus specifically on the effect of TENS in MS and stroke patients. Key words: Central neuropathic pain (CNP), central post-stroke pain (CPSP), Transcutaneous Electric Nerve Stimulation (TENS), Spinal cord injuries, Multiple Sclerosis (MS), Stroke patients.