Search

Your search keyword '"Larsen, Flemming"' showing total 1,161 results
Start Over Author "Larsen, Flemming"
1,161 results on '"Larsen, Flemming"'

2. Phenolic cross-links: building and de-constructing the plant cell wall

Author

Mnich, Ewelina, Bjarnholt, Nanna, Eudes, Aymerick, Harholt, Jesper, Holland, Claire, Jørgensen, Bodil, Larsen, Flemming Hofmann, Liu, Ming, Manat, Renil, Meyer, Anne S, Mikkelsen, Jørn Dalgaard, Motawia, Mohammed Saddik, Muschiol, Jan, Møller, Birger Lindberg, Møller, Svenning Rune, Perzon, Alixander, Petersen, Bent Larsen, Ravn, Jonas Laukkonen, and Ulvskov, Peter

Subjects
Organic Chemistry, Chemical Sciences, Carbohydrate Sequence, Cell Wall, Phenols, Plants, Biological Sciences, Medical and Health Sciences, Medicinal and biomolecular chemistry, Traditional, complementary and integrative medicine
Abstract

Covering: Up to 2019Phenolic cross-links and phenolic inter-unit linkages result from the oxidative coupling of two hydroxycinnamates or two molecules of tyrosine. Free dimers of hydroxycinnamates, lignans, play important roles in plant defence. Cross-linking of bound phenolics in the plant cell wall affects cell expansion, wall strength, digestibility, degradability, and pathogen resistance. Cross-links mediated by phenolic substituents are particularly important as they confer strength to the wall via the formation of new covalent bonds, and by excluding water from it. Four biopolymer classes are known to be involved in the formation of phenolic cross-links: lignins, extensins, glucuronoarabinoxylans, and side-chains of rhamnogalacturonan-I. Lignins and extensins are ubiquitous in streptophytes whereas aromatic substituents on xylan and pectic side-chains are commonly assumed to be particular features of Poales sensu lato and core Caryophyllales, respectively. Cross-linking of phenolic moieties proceeds via radical formation, is catalyzed by peroxidases and laccases, and involves monolignols, tyrosine in extensins, and ferulate esters on xylan and pectin. Ferulate substituents, on xylan in particular, are thought to be nucleation points for lignin polymerization and are, therefore, of paramount importance to wall architecture in grasses and for the development of technology for wall disassembly, e.g. for the use of grass biomass for production of 2nd generation biofuels. This review summarizes current knowledge on the intra- and extracellular acylation of polysaccharides, and inter- and intra-molecular cross-linking of different constituents. Enzyme mediated lignan in vitro synthesis for pharmaceutical uses are covered as are industrial exploitation of mutant and transgenic approaches to control cell wall cross-linking.

Published
2020

19. Long-term sequelae following acute pulmonary embolism : a nationwide follow-up study regarding the incidence of CTEPH, dyspnea, echocardiographic and V/Q scan abnormalities

Author

Andersson, Therese, Nilsson, Lars, Larsen, Flemming, Carlberg, Bo, Söderberg, Stefan, Andersson, Therese, Nilsson, Lars, Larsen, Flemming, Carlberg, Bo, and Söderberg, Stefan

Abstract

We aimed to follow a nationwide cohort of patients with pulmonary embolism (PE) without any exclusions to generate information regarding long-term symptoms, investigational findings and to determine the prevalence of chronic thromboembolic pulmonary hypertension (CTEPH). We hypothesized that this approach would yield generalizable estimates of CTEPH prevalence and incidence. All individuals diagnosed with acute PE in Sweden in 2005 were identified using the National Patient Register. In 2007, survivors were asked to complete a questionnaire regarding current symptoms. Those with dyspnea were referred for further examinations with laboratory tests, electrocardiogram (ECG), and a ventilation/perfusion scan (V/Q scan). If CTEPH was suspected, a referral to the nearest pulmonary arterial hypertension-center was recommended. Of 5793 unique individuals with PE diagnosis in 2005, 3510 were alive at the beginning of 2007. Altogether 53% reported dyspnea at some degree whereof a large proportion had V/Q scans indicating mismatched defects. Further investigation revealed 6 cases of CTEPH and in parallel 18 cases were diagnosed outside this study. The overall prevalence of CTEPH was 0.4% (95% confidence interval [CI]: 0.2%–0.6%) and 0.7% (95% CI: 0.4%–1.0%) among the survivors. The cumulative incidence of CTEPH in the group of patients who underwent a V/Q scan was 1.1% (95% CI: 0.2%–2.0%). There was a high mortality following an acute PE, a high proportion of persistent dyspnea among survivors, whereof several had pathological findings on V/Q scans and echocardiography. Only a minority developed CTEPH, indicating that CTEPH is the tip of the iceberg of post-PE disturbances.

Published
2023
Full Text
View/download PDF

20. 13C NMR Chemical Shifts of Saccharides in the Solid State: A Density Functional Theory Study

Author

Moustafa, Hadeel, Larsen, Flemming Hofmann, Madsen, Anders Østergaard, Sauer, Stephan P. A., Moustafa, Hadeel, Larsen, Flemming Hofmann, Madsen, Anders Østergaard, and Sauer, Stephan P. A.

Abstract

In this work we present a systematic, theoretical investigation of the 13C NMR chemical shifts for several mono-, di- and trisaccharides in the solid state. The chemical shifts have been calculated using density functional theory (DFT) together with the gauge including the projector augmented wave (GIPAW) method as implemented in the CASTEP program. We studied the changes in the 13C NMR chemical shifts in particular due to the formation of one or two glycosidic linkages and due to crystal water. The largest changes, up to 14 ppm, are observed between the mono- and disaccharides and typically for the glycosidic linkage atoms, but not in all cases. An analysis of the bond angles at the glycosidic linkage and the observed changes in chemical shifts displays no direct correlation between them. Somewhat smaller changes in the range of 2 to 5 ppm are observed when single crystal water molecules are close to some of the atoms. Relating the changes in the chemical shifts of the carbon atoms closest to the crystal water to the distance between them does, however, not lead to a simple relation between them.

Published
2023

27. Measuring Active Labour Market Polices

Author

Andersen, Niklas Andreas, Caswell, Dorte, Larsen, Flemming, Lewis, Jenny, and Triantafillou, Peter

Subjects
Post-NPM reforms, Performance, Measurements, Governance Reforms, Employment Services, Active Labour Market policy
Abstract

Active labour market polices have always been one of the most closely measured policy areas. This can be attributed, among other things, to the use of NPM-inspired governance instruments (e.g., performance measurement and outcome-based pay-for-performance schemes). The extensive use of measurements has in recent years been heavily criticized for bureaucratization and its focus on internal efficiency rather than external impact on societal and individual problems. Post-NPM reforms offer answers to these challenges. These reforms are however neither uniform nor have they replaced earlier governance paradigms. A major challenge is therefore how to make such a transition possible if legitimacy is predicated on performance measurements focused on efficiency and accountability. From what we have learned from the past 30 years of measuring in this field this will depend on how such approaches can be captured by the KPIs of performance measurement systems. Or maybe alternatively whether new measurements adapted to post-NPM logics can be developed.

Published
2023

28. The puzzling reconciliation of conditionality and personalised services in employment services: How managers, frontline workers and claimants strive to solve a Gordian Knot

Author

Caswell, Dorte, Nielsen, Mathias Herup, Larsen, Flemming, Tan Chen, Victor, Pultz, Sabina, and Sharone, Ofer

Abstract

The chapter is structured as follows: First, we describe the empirical project that we draw our knowledge from. Second, we take a deep dive into the organisations and analyse experiences with reconciling conditionality and personalised service from different perspectives in the job centres. Third, our conclusive discussion reflects how ‘system innovation’ can contribute to solving the wicked problem of balancing conditionality approaches with approaches that makes sense for the new widened target group containing vulnerable unemployed.

Published
2023

32. Introduction

Author

Greer, Ian, primary, Breidahl, Karen, additional, Knuth, Matthias, additional, and Larsen, Flemming, additional

Published
2017
Full Text
View/download PDF

34. Conclusion

Author

Greer, Ian, primary, Breidahl, Karen, additional, Knuth, Matthias, additional, and Larsen, Flemming, additional

Published
2017
Full Text
View/download PDF

36. Employment Services

Author

Greer, Ian, primary, Breidahl, Karen, additional, Knuth, Matthias, additional, and Larsen, Flemming, additional

Published
2017
Full Text
View/download PDF

40. 13 C NMR Chemical Shifts of Saccharides in the Solid State: A Density Functional Theory Study.

Author

Moustafa, Hadeel, Larsen, Flemming H., Madsen, Anders Ø., and Sauer, Stephan P. A.

Subjects
CHEMICAL shift (Nuclear magnetic resonance), DENSITY functional theory, SACCHARIDES, DENSITY of states, BOND angles, SINGLE crystals
Abstract

In this work we present a systematic, theoretical investigation of the 13C NMR chemical shifts for several mono-, di- and trisaccharides in the solid state. The chemical shifts have been calculated using density functional theory (DFT) together with the gauge including the projector augmented wave (GIPAW) method as implemented in the CASTEP program. We studied the changes in the 13C NMR chemical shifts in particular due to the formation of one or two glycosidic linkages and due to crystal water. The largest changes, up to 14 ppm, are observed between the mono- and disaccharides and typically for the glycosidic linkage atoms, but not in all cases. An analysis of the bond angles at the glycosidic linkage and the observed changes in chemical shifts displays no direct correlation between them. Somewhat smaller changes in the range of 2 to 5 ppm are observed when single crystal water molecules are close to some of the atoms. Relating the changes in the chemical shifts of the carbon atoms closest to the crystal water to the distance between them does, however, not lead to a simple relation between them. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

43. Magnesium(II)‐ATP Complexes in 1‐Ethyl‐3‐Methylimidazolium Acetate Solutions Characterized by 31 Mg β‐Radiation‐Detected NMR Spectroscopy

Author

McFadden, Ryan M. L., primary, Szunyogh, Dániel, additional, Bravo‐Frank, Nicholas, additional, Chatzichristos, Aris, additional, Dehn, Martin H., additional, Fujimoto, Derek, additional, Jancsó, Attila, additional, Johannsen, Silke, additional, Kálomista, Ildikó, additional, Karner, Victoria L., additional, Kiefl, Robert F., additional, Larsen, Flemming H., additional, Lassen, Jens, additional, Levy, C. D. Philip, additional, Li, Ruohong, additional, McKenzie, Iain, additional, McPhee, Hannah, additional, Morris, Gerald D., additional, Pearson, Matthew R., additional, Sauer, Stephan P. A., additional, Sigel, Roland K. O., additional, Thulstrup, Peter W., additional, MacFarlane, W. Andrew, additional, Hemmingsen, Lars, additional, and Stachura, Monika, additional

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results