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2 results on '"Larrudé DG"'

1. In vitro Antifungal Activity of Baccharis trimera Less (DC) Essential Oil against Dermatophytes

Author

Caneschi, CA, Martins, FJ, Larrudé, DG, Romani, EC, Brandão, MAF, and Raposo, NRB

Subjects
Baccharis trimera, Fungi, Onychomycosis, Dermatophytes, Antifungal
Abstract

Purpose: To identify the main components of the essential oil (EO) of Baccharis trimera Less and investigate their in vitro antifungal activity against seven fungal strains that cause onychomycosis.Methods: The chemical composition of EO was determined using gas chromatography, and its minimum inhibitory concentration (MIC), minimum fungicidal concentration (MFC), and antifungal activity were compared with those of terbinafine and ketoconazole. Scanning electron microscopy (SEM) was used to investigate morphological changes in the strains of interest.Results: Twenty compounds, with β-pinene being the major constituent (23.4 %), were identified in EO. EO exhibited fungicide potential, with MFC values in the range of 0.06 to 125 μg mL−1, which were lower than those of the reference drugs against Trichophyton rubrum CCT 5507 URM1666 and Microsporum canis ATCC 32903. MIC range for the compounds was from 0.03 to 125 μg mL−1 for five strains of the fungi evaluated. For Trichophyton mentagrophytes ATCC 11481 and Epidermophyton floccosum CCFIOC 3757, MIC was ≥ 1000 μg mL−1. Flattening, distortions, and shrinkage were observed in the SEM images of structures of the five fungal species that were subjected to the action of the EO.Conclusion: The results indicate that EO has antifungal activity against filamentous fungi and may be developed as an alternative for the treatment of onychomycosis.Keywords: Baccharis trimera, Fungi, Onychomycosis, Dermatophytes, Antifungal

Published
2015

2. Indirect voltammetric determination of thiomersal in influenza vaccine using photo-degradation and graphene quantum dots modified glassy carbon electrode.

Author

Pedrozo-Penafiel MJ, Miranda-Andrades JR, Gutierrez-Beleño LM, Larrudé DG, and Aucelio RQ

Subjects
Electrodes, Particle Size, Photochemical Processes, Surface Properties, Carbon chemistry, Electrochemical Techniques, Influenza Vaccines chemistry, Quantum Dots chemistry, Thimerosal analysis
Abstract

Thiomersal is an organomercury derivative that degrades producing thiosalicylic acid, dithiobenzoic acid and ethylmercury. It is widely used in topical pharmaceutical preparations and as preservative in vaccines and cosmetics. In this work, an electro-analytical method for thiomersal was developed using graphene quantum dots (GQDs) as a surface modifier of a glassy carbon electrode. The method rely on using square-wave voltammetry and exploring the synergistic effect between GQDs, visible radiation and the applied potential in producing very intense Hg oxidation peak during the anodic scan. A linear voltammetric response was obtained for the analyte in the concentration range from 3.0 μmol L -1 (1.2 μg mL -1 ) to 32 μmol L -1 (12 μg mL -1 ), with a detection limit of 0.9 μmol L -1 (0.34 μg mL -1 ). The proposed method was successfully applied for thiomersal determination in influenza vaccine., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 Elsevier B.V. All rights reserved.)

Published
2020
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