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216 results on '"Larrat, Benoit"'

1. Transcranial ultrasound simulations: a review

Author

Angla, Celestine, Larrat, Benoit, Gennisson, Jean-Luc, and Chatillon, Sylvain

Subjects
Physics - Medical Physics
Abstract

Transcranial ultrasound is more and more used for therapy and imaging of the brain. However, the skull is a highly attenuating and aberrating medium, with different structures and acoustic properties between samples and even within a sample. Thus, case-specific simulations are needed to perform transcranial focused ultrasound interventions safely. In this article, we provide a review of the different methods used to model the skull and to simulate ultrasound propagation through it.

Published
2022

8. AGuIX® from bench to bedside—Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine

Author

Lux, François, Tran, Vu Long, Thomas, Eloïse, Dufort, Sandrine, Rossetti, Fabien, Martini, Matteo, Truillet, Charles, Doussineau, Tristan, Bort, Guillaume, Denat, Franck, Boschetti, Frédéric, Angelovski, Goran, Detappe, Alexandre, Crémillieux, Yannick, Mignet, Nathalie, Doan, Bich-Thuy, Larrat, Benoit, Meriaux, Sébastien, Barbier, Emmanuel, Roux, Stéphane, Fries, Peter, Müller, Andreas, Abadjian, Marie-Caline, Anderson, Carolyn, Canet-Soulas, Emmanuelle, Bouziotis, Penelope, Barberi-Heyob, Muriel, Frochot, Céline, Verry, Camille, Balosso, Jacques, Evans, Michael, Sidi-Boumedine, Jacqueline, Janier, Marc, Butterworth, Karl, McMahon, Stephen, Prise, Kevin, Aloy, Marie-Thérèse, Ardail, Dominique, Rodriguez-Lafrasse, Claire, Porcel, Erika, Lacombe, Sandrine, Berbeco, Ross, Allouch, Awatef, Perfettini, Jean-Luc, Chargari, Cyrus, Deutsch, Eric, Le Duc, Géraldine, and Tillement, Olivier

Subjects
Medical Biotechnology, Biomedical and Clinical Sciences, Nanotechnology, Cancer, Bioengineering, Rare Diseases, Animals, Brain Neoplasms, Forecasting, Gadolinium, Head and Neck Neoplasms, Humans, Melanoma, Mice, Nanoparticles, Radiation-Sensitizing Agents, Theranostic Nanomedicine, Clinical Sciences, Nuclear Medicine & Medical Imaging, Clinical sciences, Oncology and carcinogenesis
Abstract

AGuIX® are sub-5 nm nanoparticles made of a polysiloxane matrix and gadolinium chelates. This nanoparticle has been recently accepted in clinical trials in association with radiotherapy. This review will summarize the principal preclinical results that have led to first in man administration. No evidence of toxicity has been observed during regulatory toxicity tests on two animal species (rodents and monkeys). Biodistributions on different animal models have shown passive uptake in tumours due to enhanced permeability and retention effect combined with renal elimination of the nanoparticles after intravenous administration. High radiosensitizing effect has been observed with different types of irradiations in vitro and in vivo on a large number of cancer types (brain, lung, melanoma, head and neck…). The review concludes with the second generation of AGuIX nanoparticles and the first preliminary results on human.

Published
2019

20. Efficient PD-L1 imaging of murine glioblastoma with FUS-aided immunoPET by leveraging FcRn-antibody interaction

Author

Chevaleyre, Céline, primary, Novell, Anthony, additional, Tournier, Nicolas, additional, Dauba, Ambre, additional, Dubois, Steven, additional, Kereselidze, Dimitri, additional, Selingue, Erwan, additional, Jego, Benoit, additional, Maillère, Bernard, additional, Larrat, Benoit, additional, Nozach, Hervé, additional, and Truillet, Charles, additional

Published
2023
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21. Monitoring de la cavitation pendant les thérapies ultrasonores guidées par IRM

Author

Ishak, Ounay, Breton, Élodie, Cabras, Paolo, Mondou, Paul, Larrat, Benoit, Vappou, Jonathan, Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, and Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[INFO.INFO-IM]Computer Science [cs]/Medical Imaging
Published
2023

25. Perfluorocarbon Nanodroplets as Potential Nanocarriers for Brain Delivery Assisted by Focused Ultrasound-Mediated Blood–Brain Barrier Disruption

Author

Bérard, Charlotte, primary, Desgranges, Stéphane, additional, Dumas, Noé, additional, Novell, Anthony, additional, Larrat, Benoit, additional, Hamimed, Mourad, additional, Taulier, Nicolas, additional, Estève, Marie-Anne, additional, Correard, Florian, additional, and Contino-Pépin, Christiane, additional

Published
2022
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28. Combination of thermal ablation by focused ultrasound, pFAR4-IL-12 transfection and lipidic adjuvant provide a distal immune response

Author

Do, Hai Doan, primary, Marie, Corinne, additional, Bessoles, Stéphanie, additional, Dhotel, Hélène, additional, Seguin, Johanne, additional, Larrat, Benoit, additional, Doan, Bich-Thuy, additional, Scherman, Daniel, additional, Escriou, Virginie, additional, Hacein-Bey-Abina, Salima, additional, and Mignet, Nathalie, additional

Published
2022
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30. Transcranial ultrasound simulations: A review.

Author

Angla, Célestine, Larrat, Benoit, Gennisson, Jean-Luc, and Chatillon, Sylvain

Subjects
*ULTRASONIC imaging, *TRANSCRANIAL Doppler ultrasonography, *HIGH-intensity focused ultrasound, *BRAIN imaging, *SKULL
Abstract

Transcranial ultrasound is more and more used for therapy and imaging of the brain. However, the skull is a highly attenuating and aberrating medium, with different structures and acoustic properties among samples and even within a sample. Thus, case-specific simulations are needed to perform transcranial focused ultrasound interventions safely. In this article, we provide a review of the different methods used to model the skull and to simulate ultrasound propagation through it. [ABSTRACT FROM AUTHOR]

Published
2023
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38. Passive RF shimming for 7T head coil with hybridized meta-atom: In vivo investigation

Author

Dubois, Marc, Leroi, Lisa, Raolison, Zo, Abdeddaim, Redha, Antonakakis, Tryfon, de Rosny, Julien, Vignaud, Alexandre, Sabouroux, Pierre, Georget, Elodie, Larrat, Benoit, Tayeb, Gérard, Bonod, Nicolas, Amadon, Alexis, Mauconduit, Franck, Poupon, Cyril, Le Bihan, Denis, Enoch, Stefan, Institut FRESNEL (FRESNEL), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Service NEUROSPIN (NEUROSPIN), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Multiwave Imaging, Institut Langevin - Ondes et Images (UMR7587) (IL), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), European Project: 736937,H2020,H2020-FETOPEN-1-2016-2017,M-CUBE(2017), Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU), Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)

Subjects
[PHYS]Physics [physics], [SPI.ELEC]Engineering Sciences [physics]/Electromagnetism, [SDV.IB]Life Sciences [q-bio]/Bioengineering, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020

39. Empirical and Theoretical Characterization of the Diffusion Process of Different Gadolinium-Based Nanoparticles within the Brain Tissue after Ultrasound-Induced Permeabilization of the Blood-Brain Barrier

Author

Conti, Allegra, Magnin, Remi, Gerstenmayer, Matthieu, Tsapis, Nicolas, Dumont, Erik, Tillement, Olivier, Lux, François, Le Bihan, Denis, Mériaux, Sébastien, Della Penna, Stefania, Larrat, Benoit, Service NEUROSPIN (NEUROSPIN), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Image Guided Therapy (IGT), Formation, élaboration de nanomatériaux et cristaux (FENNEC), Institut Lumière Matière [Villeurbanne] (ILM), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Department of Clinic Sciences and Bioimaging, University G. d'Annunzio Chieti-Pescara, European Project: 600382,EC:FP7:PEOPLE,FP7-PEOPLE-2012-COFUND,ENHANCED EUROTALENTS(2014), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut Galien Paris-Sud (IGPS), Université Paris-Sud - Paris 11 (UP11)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon

Subjects
Male, lcsh:Medical technology, Article Subject, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Sulfur Hexafluoride, Contrast Media, Nanoconjugates, Capillary Permeability, Rats, Sprague-Dawley, Diffusion, [SPI]Engineering Sciences [physics], Meglumine, Heterocyclic Compounds, Organometallic Compounds, Animals, Particle Size, Phospholipids, Microbubbles, Phantoms, Imaging, Settore FIS/07, Corpus Striatum, Rats, lcsh:R855-855.5, Ultrasonic Waves, Blood-Brain Barrier, Extracellular Space, Algorithms, Research Article
Abstract

International audience; Low-intensity focused ultrasound (FUS), combined with microbubbles, is able to locally, and noninvasively, open the blood-brain barrier (BBB), allowing nanoparticles to enter the brain. We present here a study on the di usion process of gadolinium-based MRI contrast agents within the brain extracellular space after ultrasound-induced BBB permeabilization. ree compounds were tested (MultiHance, Gadovist, and Dotarem). We characterized their di usion through in vivo experimental tests supported by theoretical models. Speci cally, by estimation of the free di usion coe cients from in vitro studies and of apparent di usion coe cients from in vivo experiments, we have assessed tortuosity in the right striatum of 9 Sprague Dawley rats through a model correctly describing both vascular permeability as a function of time and di usion processes occurring in the brain tissue. is model takes into account acoustic pressure, particle size, blood pharmacokinetics, and di usion rates. Our model is able to fully predict the result of a FUS-induced BBB opening experiment at long space and time scales. Recovered values of tortuosity are in agreement with the literature and demonstrate that our improved model allows us to assess that the chosen permeabilization protocol preserves the integrity of the brain tissue.

Published
2019

40. MR imaging of theranostic Gd-based Aguix nanoparticles in patients with 4 histological types of brain metastasis

Author

Verry, Camille, Dufort, Sandrine, Lemasson, Benjamin, Grand, Sylvie, Crémillieux, Yannick, Lux, François, Meriaux, Sébastien, Larrat, Benoit, Balosso, Jacques, Le Duc, Géraldine, Barbier, Emmanuel L, Tillement, Olivier, CHU Grenoble, NH TherAguix SA [Meylan], [GIN] Grenoble Institut des Neurosciences (GIN), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Institut des Sciences Moléculaires (ISM), Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut Lumière Matière [Villeurbanne] (ILM), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, IFR49 - Neurospin - CEA, Commissariat à l'énergie atomique et aux énergies alternatives (CEA), ANR-19-P3IA-0003,MIAI,MIAI @ Grenoble Alpes(2019), Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1 (UB)-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.IB]Life Sciences [q-bio]/Bioengineering, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019

44. Targeting brain metastases with ultrasmall theranostic nanoparticles, a first-in-human trial from an MRI perspective

Author

Verry, Camille, primary, Dufort, Sandrine, additional, Lemasson, Benjamin, additional, Grand, Sylvie, additional, Pietras, Johan, additional, Troprès, Irène, additional, Crémillieux, Yannick, additional, Lux, François, additional, Mériaux, Sébastien, additional, Larrat, Benoit, additional, Balosso, Jacques, additional, Le Duc, Géraldine, additional, Barbier, Emmanuel L., additional, and Tillement, Olivier, additional

Published
2020
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46. First-in-human trial of Gd-based theranostic nanoparticles: MRI assessment of uptake and biodistribution in patients with multiple brain metastases

Author

Dufort, Sandrine, Verry, Camille, Lemasson, Benjamin, Grand, Sylvie, Crémillieux, Yannick, Lux, François, Mériaux, Sébastien, Larrat, Benoit, Balosso, Jacques, Duc, Géraldine Le, Barbier, Emmanuel L., Tillement, Olivier, NHTheraguix [Crolles], CHU Grenoble, [GIN] Grenoble Institut des Neurosciences (GIN), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Institut des Sciences Moléculaires (ISM), Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut Lumière Matière [Villeurbanne] (ILM), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Service NEUROSPIN (NEUROSPIN), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, ANR-19-P3IA-0003,MIAI,MIAI @ Grenoble Alpes(2019), Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1 (UB)-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)

Subjects
[SDV.IB]Life Sciences [q-bio]/Bioengineering
Abstract

International audience; We report here the main MRI findings of a dose escalation phase 1 clinical trial with intravenous administration of theranostic AGuIX nanoparticles, conducted in 15 patients with brain metastases with the objective of evaluating the efficacy of the nanoparticles as contrast agent and radiosensitizer for brain metastases. The nanoparticles were found to enhance four different histological types of brain metastases up to one week after nanoparticle administration. Quantitative measurements of nanoparticle concentration in all types of brain metastases were obtained two hours after administration to patient - and incidentally two hours before the first session of whole brain radiotherapy.

Published
2019

47. Robotic Trajectories For Blood-Brain Barrier Opening With Focused Ultrasound On Large Areas

Author

Thomas, Gaelle, Barbé, Laurent, Larrat, Benoit, Vappou, Jonathan, univOAK, Archive ouverte, Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Matériaux et nanosciences d'Alsace (FMNGE), and Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SPI.AUTO] Engineering Sciences [physics]/Automatic, [SPI.AUTO]Engineering Sciences [physics]/Automatic
Published
2019

48. In Vitro Investigation of Titanium Nitride Nanoparticles as Photo-Absorbing Agent for Photothermal Therapy

Author

Dumas, Noé, Bastiancich, Chiara, Berard, Charlotte, Metwally, Khaled, Jones, Nicola, Tselikov, Gleb, Popov, Anton A., Al-Kattan, Ahmed, Kabashin, Andrei V., Larrat, Benoit, Braguer, Diane, Mensah, Serge, Silva, Anabela Da, Esteve, Marie-Anne, Institut de neurophysiopathologie (INP), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Ondes et Imagerie (O&I), Laboratoire de Mécanique et d'Acoustique [Marseille] (LMA ), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), DiMABio (DiMABio), Institut FRESNEL (FRESNEL), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Lasers, Plasmas et Procédés photoniques (LP3), Service NEUROSPIN (NEUROSPIN), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM), Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay

Subjects
[PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics], [SDV.BIO]Life Sciences [q-bio]/Biotechnology, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

49. Titanium Nitride Nanoparticles as Photo-Absorbing Carriers of Photothermal Glioblastoma Therapy In Vitro Investigation

Author

Bastiancich, Chiara, Correard, Florian, Novell, Anthony, Chaspoul, Florence, Dumas, Noé, Metwally, Khaled, Tselikov, Gleb, Popov, Anton A., Al-Kattan, Ahmed, Kabashin, Andrei V., Larrat, Benoit, Braguer, Diane, Mensah, Serge, Silva, Anabela Da, Esteve, Marie-Anne, Institut de neurophysiopathologie (INP), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), Ondes et Imagerie (O&I), Laboratoire de Mécanique et d'Acoustique [Marseille] (LMA ), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM), DiMABio (DiMABio), Institut FRESNEL (FRESNEL), Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU), Laboratoire Lasers, Plasmas et Procédés photoniques (LP3), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Service NEUROSPIN (NEUROSPIN), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), and Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics], [SDV.BIO]Life Sciences [q-bio]/Biotechnology, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

50. Amphiphilic and Perfluorinated Poly(3-Hydroxyalkanoate) Nanocapsules for 19F Magnetic Resonance Imaging.

Author

Le Gal, Marion, Renard, Estelle, Simon-Colin, Christelle, Larrat, Benoit, and Langlois, Valérie

Subjects
MAGNETIC resonance imaging, NANOCAPSULES, CONTRAST media, MARINE bacteria
Abstract

Nanoparticles have recently emerged as valuable tools in biomedical imaging techniques. Here PEGylated and fluorinated nanocapsules based on poly(3-hydroxyalkanoate) containing a liquid core of perfluorooctyl bromide PFOB were formulated by an emulsion-evaporation process as potential 19F MRI imaging agents. Unsaturated poly(hydroxyalkanoate), PHAU, was produced by marine bacteria using coprah oil and undecenoic acid as substrates. PHA-g-(F; PEG) was prepared by two successive controlled thiol-ene reactions from PHAU with firstly three fluorinated thiols having from 3 up to 17 fluorine atoms and secondly with PEG-SH. The resulting PHA-g-(F; PEG)-based PFOB nanocapsules, with a diameter close to 250-300 nm, are shown to be visible in 19F MRI with an acquisition time of 15 min. The results showed that PFOB-nanocapsules based on PHA-g-(F; PEG) have the potential to be used as novel contrast agents for 19F MRI. [ABSTRACT FROM AUTHOR]

Published
2021
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