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121 results on '"Larin, O."'

2. Improving planning methods for the transportation of electronic household waste in large cities.

Author

Nguyen, T. T. H. and Larin, O.

Subjects
*ELECTRONIC waste, *CITIES & towns, *TRANSPORTATION planning, *WASTE management, *HAZARDOUS substances, *ELECTRONIC waste disposal
Abstract

The article discusses the advantages of arranging the removal of electronic household waste according to the data on the actual volumes of accumulation at collection points. Such waste contains many substances hazardous to the environment and human health and therefore must be disposed of at special facilities in compliance with special technological conditions. If the waste is not removed when the capacity of the collection points is exhausted, otherwise there is a risk of waste disposal in violation of the established requirements. In this paper, the calculation and comparison of the costs of waste disposal by the method "with the established frequency" and "by the actual filling" was made. The results showed the cost-effectiveness of the second method. Arrangement of removal according to the data on the actual volumes of filling the storage capacity of collection points will increase the level of waste collection. [ABSTRACT FROM AUTHOR]

Published
2023
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3. Automation of work planning processes for passenger transport drivers on urban routes.

Author

Kapski, D., Semchenkov, S., Larin, O., Almetova, Z., and Tarasov, D.

Subjects
PRODUCTION planning, CITIES & towns, AUTOMATION, WORKING hours, PASSENGER traffic
Abstract

The article discusses the urgent tasks to improve the process of planning the work of vehicle drivers on city routes. To arrange high-quality and safe transportation of passengers, it is necessary to plan the timely release of vehicles on the line, as well as the order of work of drivers. Plans for entering the line of vehicles and work schedules for drivers are developed for all days of the coming month. The planned parameters of the operation of vehicles on the routes must ensure the transportation of all passengers in compliance with quality requirements. The planned parameters of the drivers' work must ensure uninterrupted transportation in compliance with the requirements for the work and rest hours of personnel. During each day, depending on the operational situation on the routes, changes are made to the work plans. Transportation companies in large cities spend significant funds on developing and changing plans. To reduce planning costs, an algorithm for automating the development of daily orders for the work of vehicle drivers on city routes is offered. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Простий зсув: власні вектори тензорів коші-гріна обернені один проти іншого

Author

Itskov, M. and Larin, O. O.

Subjects
simple shear, rotation, eigenvectors, Cauchy-Green tensors, простий зсув, обертання, власні вектори, тензори Коші-Гріна
Abstract

Простий зсув являє собою дещо складний випадок деформації, хоча він дуже добре вивчений. У цій роботі ми обговорюємо новий аспект простого зсуву, який раніше не спостерігався. Теоретично вивчаються обертання власних векторів правого та лівого тензорів Коші-Гріна зі збільшенням кількості зсуву під кінематично визначеним простим зсувом. Аналіз зроблено в рамках нелінійної теорії пружності. Математичний процесор Maple використовується для обчислень та анімації результатів. З’являються взаємно протилежні обертання власних векторів правого та лівого тензорів Коші-Гріна, які можуть мати важливе значення для анізотропних і зокрема армованих волокнами матеріалів., Простой сдвиг представляет собой довольно сложный случай деформации, хотя он очень хорошо изучен. В этой статье мы обсуждаем новый аспект простого сдвига, который ранее не наблюдался. Показано, что собственные векторы правого и левого тензоров Коши-Грина вращаются друг против друга с увеличением количества сдвига. Это подтверждает вывод о сложности простого сдвига., Simple shear represents a somewhat complex case of deformation although it is very good studied. In this paper, we discuss a new aspect of simple shear which has not been observed before. Rotations of the eigenvectors of the right and left Cauchy-Green tensors with increasing amount of shear under the kinematically defined simple shear are theoretically studied. An analysis has been done within a framework of the nonlinear theory of elasticity. Mathematical processor Maple is used for the calculations and animation of the results. Phenomena of mutually opposite rotations of the eigenvectors of the right and left Cauchy-Green tensors is fond that can be important for anisotropic and in particular fibre-reinforced materials. We studied rotations of principal strain directions under the kinematically defined simple shear. Accordingly, eigenvectors of the right and left Cauchy-Green tensors rotate against each other with the increasing amount of shear. Interestingly, the eigenvectors of b rotate in the same direction as line elements of the material while the eigenvectors of C in the opposite direction. For example, this can be important for anisotropic and in particular fiber reinforced materials. In this case, the direction of the maximal stretch will rotate with respect to reinforcement directions.

Published
2019

27. Reliability of the Rubber Tube of Automotive Hydraulic Braking System Under Fatigue Failures Considering Random Variation of Load and the Process of Aging of Material

Author

Larin, O. O., Potopalska, K. E., and Mygushchenko, R. P.

Subjects
life-time, fatigue, composite, rubber pipe
Abstract

This paper presents the approach for the assessing of the operational reliability of a multi-layer thick-walled tube made of rubber with textile reinforcement. The analysis of the fatigue accumulation process is carried out within the framework of the concept of the continuum mechanics of damage. The mathematical model, which takes into account the accumulation of damages in case of a random spread of the strength characteristics of the material, as well as the process of stochastic aging for the elastomeric matrix of the composite and possible random variation of the workload has been developed. In this case, the aging process is modelled as a reduction of the endurance limit of the material. In this paper, the mean equivalent strains of the tube and their possible statistical variation in operation have been investigated on the basis of the finite element method. To solve the above problems, a submodeling method has been employed in this work. The probability of non-failure operation of the tube has been determined using the methods and models proposed. The influence of the rate of the aging process on the lifetime of the tube has been estimated.

Published
2019

28. Assessment of the residual resource of the elements of construction of the pump of the energy installation on the basis of statistical assessment of total strenght

Author

Larin, O. O., Potopalska, K. E., and Chetverikova, A. S.

Subjects
life-time, corrosion wear, reliability, power engineering equipment, residual strength, ресурс, корозійне зношення, надійність, енергетичне обладнання, залишкова міцність
Abstract

Оцінка залишкового ресурсу елементів конструкції насосу енергетичної установки на основі статистичної оцінки втомної міцності з прогнозованим стоншенням корпусних деталей внаслідок корозії, Оценка остаточного ресурса элементов конструкции насоса энергетической установки на основе статистической оценки усталостной прочности с прогнозируемым истончением корпусных деталей вследствие коррозии, Assessment of the residual resource of the elements of construction of the pump of the energy installation on the basis of statistical assessment of total strength

Published
2019

29. Analysis of the Elastic Characteristics of a Pneumatic Shock Absorber

Author

Larin, O. O. and Beskrovnyi, Y. Y.

Subjects
Пневматический амортизатор, прорезиненный композиционный материал, физически и геометрически нелинейное деформирование, интегральная жесткость, микроструктура композита, Quantitative Biology::Tissues and Organs, Пневмоамотизатор, гумокордний матеріал, фізично та геометрична нелінійніність деформування, інтегральна жорсткість, мікроструктура композиту, Pneumatic shock absorber, rubberized composite material, physically and geometric nonlinear of deformation, integral stiffness, the composite microstructure
Abstract

The article deals with a computer analysis of the pneumatic shock absorber deformed state, as well as the peculiarities of the formation of its integral elastic characteristics. The Deformation process is considered under internal pressure and the normal axial compression load. The construction of pneumatic shock absorber consists of two-section pneumatic rubberized single-layer composite bellows, which has circular metal constraints on the edges and in the middle.The research is done in a framework of a geometric and physically three-dimensional nonlinear formulation. The modelling of the nonlinear deformation of the rubber matrix is based on a three-parameter Muni-Rivlin model. A finite-element method is used for numerical solution of the problem. The composite reinforcement models as integral membrane stiffness additionally inserted into the corresponding finite elements, taking into account the cord orientation, that allows taking into account a toroidal curvilinear orthotropy of mechanical properties of the material.The dependences of the pneumatic shock absorber quasi-static deformation on the cord geometric and stiffness parameters is analysed in the current work. It is studied the influence of the variation of cord diameter and cord material Young modulus on the integral elastic behavior of the pneumatic shock absorber under the different compression load. The last allows us to analyze the influence of the cord material on load characteristic of construction., Статья посвящена компьютерному анализу деформированного состояния пневматического амортизатора, а также особенностям формирования его интегральных упругих характеристик. Конструкция пневматического амортизатора состоит из двухсекционного пневматического прорезиненного однослойного композитного сильфона. Исследование проводится в рамках геометрической и физически нелинейной трехмерной формулировки. Моделирование деформации резиновой матрицы основано на модели Муни-Ривлина. Для численного решения задачи используется метод конечных элементов. Композитное армирование моделируется как интегральная мембранная жесткость, которая дополнительно вставляется в соответствующие конечные элементы. В работе была исследована зависимость квазистатической деформации пневматического амортизатора от диаметра корда, а также от его модуля упругости., Стаття присвячена компютерному аналізу напружено-деформованого стану пневмоамортизатора, а також особливостей формування його інтегральної пружної характеристики. Розглядається двосекційний пневмоамотизатор сильфоного типу, який створений із гумокордного одношарового композиту, що має кільцеві металеві обмежання по торцам та в середині конструкції. Дослідження проводиться в тривимірній геометрично та фізично нелінійній постановці. Моделювання деформування гумової матриці проведено на основі моделі Муні-Рівліна. Для вирішення задачі використовуєьтся метод скінченних елементів. Кордне посилення моделюється шляхом інтегрального додавання мембраної жорсткості у відповідні скінченні елементи. В роботі проаналізовано залежність пружної характеристики амортизатора від діаметру та модуля пружності корду.

Published
2018

30. Statistical Estimation of Residual Strength and Reliability of Corroded Pipeline Elbow Part Based on a Direct FE-Simulations

Author

Larin, O. O., Potopalska, K. E., and Mygushchenko, R. P.

Subjects
reliability, corrosion damage, volumetric surface defect, plastic strains, pipeline
Abstract

In this paper, the assessment of the effect of a corrosion defect, which is developing over time on the working capacity of the pipeline elbow, has been carried out. Corrosion damage models explicitly as volumetric defect on the out surface of the pipeline elbow. The zones on the damaged section of the pipeline on which the maximum stresses are localized has been defined using the finite element analysis. The estimation of the characteristics of the deformed state of a design with defect is analysed with the framework of computer simulations. On the basis of the obtained results, the probabilistic characteristics of the stresses and plastic strains have been approximated as a function of internal pressure and corrosion defect depth, such as mean value, coefficients of variation and asymmetry. Probability densities function of plasticity appearance have been found for different defect size in operation at typical loading levels.

Published
2018

32. Effects of once-weekly exenatide on cardiovascular outcomes in type 2 diabetes

Author

Holman, Rr, Bethel, Ma, Mentz, Rj, Thompson, Vp, Lokhnygina, Y, Buse, Jb, Chan, Jc, Choi, J, Gustavson, Sm, Iqbal, N, Maggioni, Ap, Marso, Sp, Öhman, P, Pagidipati, Nj, Poulter, N, Ramachandran, A, Zinman, B, Hernandez, Af, EXSCEL Study Group, : Califf RM, Patel, R, George, J, Sourij, H, Wong, Yw, Hannan, K, Sellers, Ma, Gottlieb, P, Lavender, P, Leloudis, D, Meadows, Y, Larson, D, Anderson, H, Elkins, M, Stone, A, Tisch, A, Perkins, L, Sanders, K, Campbell, C, Kennedy, I, Heal, P, Masterson, M, Darbyshire, J, Mumtaz, L, Athwal, R, Ferch, A, Batra, P, Durborow, L, Vincent, J, Woodall, A, Flanagan, T, Katona, B, Reicher, B, Pozzi, E, Oulhaj, A, Coleman, R, Rouleau, Jl, Pocock, Sj, Gorelick, F, Mcmurray, J, Riddle, M, Gagel, R, Collier, T, Markovic, T, Kong, Aps, Hian, Sk, Scott, R, Panelo, A, Yoon, Kh, Sheu, W, Sritara, P, Linong, J, Pan, C, Yong, H, Schernthaner, G, Mathieu, C, Tankova, T, Widimsky, P, Hanefeld, M, Keltai, M, Wainstein, J, del Prato, S, Pirags, V, Jakuboniene, N, Kooy, A, Dziemidok, P, Veresiu, Ia, Dreval, Av, Murin, J, Torello, Al, Sattar, N, Parkhomenko, O, Omar, M, Diaz, R, Lopes, R, Lanas, F, Urina Triana, M, Leiva-Pons, Jl, Aguliera, D, Bergenstal, R, Goodman, S, Yale, Jf, Caterson, I, Weng, J, Hu, D, Junbo, G, Zannad, F, Anoop, M, Ambrish, M, Gallegos, Ja, Green, Jb, Akerblom, A, Alexander, K, Al-Khatib, S, Armaganijan, L, Barros, P, Batit, M, Bernacki, G, Bernandez, S, Bloomfield, G, Clausen, E, De Souza Brito, F, Devore, A, Dombrowski, K, Eapen, Z, Gellad, Z, George, D, Guimaraes, P, Halim, S, Harrison, R, Hawes, J, Hess, C, Hyland, K, Jackson, L, Jones, S, Jordan, D, Katz, M, Kong, D, Koshizaka, M, Lakey, W, Leblanc, T, Leonardi, S, Luo, N, Mahaffey, K, Mandawat, A, Mehta, R, Melloni, C, Morse, M, Pagidpati, N, Patel, C, Patel, K, Pokorney, S, Posvic, T, Rao, M, Roe, M, Shah, B, Tillmann, H, Truffa, A, Zazula, A, Zeitler, E, Sicer, M, Ulla, Mr, Maffei, L, Klyver, Mi, Calella, P, Alvarisqueta, A, De La Fuente RL, Aizenberg, D, Roque, F, Cruciani, A, Frechtel, G, Gelersztein, E, Villarino, A, Mallagray, M, Nardone, L, Zaidman, C, Novaretto, L, Bartolacci, I, de Salvo, M, Delcourt, C, Crimmins, D, Jackson, R, O’Neal, D, Colman, P, Jeffries, W, Mah, Pm, Wittert, G, Proietto, J, Amerena, J, Marks, S, Tan, R, Colquhoun, D, Pieber, T, Drexel, H, Prager, R, Schnack, C, Hoppichler, F, Fasching, P, Francesconi, C, Luger, A, Schoenherr, Hr, Ebenbichler, C, Paulweber, B, Shernthaner, G, Verhaegen, A, Vanuytsel, J, Thissen, Jp, e Silva P, Barros, Gonzaga, C, Borges, J, Hissa, M, Rea, R, Rossi, P, Chacra, A, Eliaschewitz, F, Garbelini, B, Felicio, J, Rassi, N, Rossi, F, Nunes dos Santos, M, e Farias F, Bandeira, Lisboa, H, e Forti A, Costa, Saraiva, Jk, Kovacheva, S, Levterov, G, Sheinkova, G, Ilieva, E, Lyubenova, L, Damyanova, V, Gushterova, V, Mincheva, L, Illiev, D, Ivanov, V, Bobeva, R, Nikitov, Z, Shumkova, R, Lefterov, In, Zaharieva, S, Videva, V, Yakov, A, Cheung, S, Elliott, T, Mehta, P, Ross, S, Sigal, R, Woo, V, Jaffer, S, Kuritsky, R, Bell, A, Dumas, R, Gosselin, G, Robitaille, Y, Greenspoon, A, Lochnan, H, Tytus, R, Leiter, L, Pandey, A, Punthakee, Z, Dube, F, Sigalas, J, Pearce, M, Woodford, T, Paul, P, Bourgeois, R, Conway, R, Mazza, G, Hatheway, R, Misterski, J, Raffo, C, Olivares, C, Godoy, J, Potthoff, S, Santibañez, C, Larenas Yanez GJ, Gu, W, Shen, F, Ma, J, Guo, X, Li, Q, Du, Y, Hu, J, Ji, L, Li, Y, Deng, H, Feng, Y, Liu, L, Mu, Y, Ma, C, Qu, S, Wang, J, Wang, Y, Yuan, Z, Zhang, L, Zhou, S, Yang, T, Dong, Y, Liu, D, Coronel Arroyo, J, Perez Amador, G, Botero Lopes, R, Jaramilo, C, Orozco Linares, A, Cure Cure CA, Hernandez Triana, E, Molina de Salazar DI, Marin, Cr, Jaramilo Gomez CJ, Kellinerova, I, Adamkova, V, Krami, P, Brychta, T, Havelkova, J, Pantikova, K, Schoper, F, Pohl, W, Schumm-Draeger, Pm, Julius, U, Tschöpe, D, Hamann, A, Seissler, J, Schellong, S, Rose, L, Becker, B, Linn, T, Oerter, Em, Strotmann, Hj, Mölle, A, Pfutzner, A, Forst, T, Schäufele, T, Mugge, A, Lehrke, M, Meyer-Pannwitt, U, Mehling, H, Simon-Wagner, I, Schenkenberger, I, Busch, K, Hermes, S, Milek, K, Landers, B, Grueneberg, M, Braun, M, Nothroff, J, Kamke, W, Hergdt, G, Duengen, Hd, Kleinertz, K, Kuesters, D, Boenninghoff, Ah, Appel, Kf, Schaefer, A, Bieler, T, Ozaki, R, Luk, Aoy, Chu, Dw, Cheung-Wong, Mm, Siu, Dc, Yan, Bpy, Kung, K, Wong, Sys, Tsang, Cc, Yeung, Vt, Cheung, Bm, Tse, Hf, Hodi, G, Nagy, K, Lippai, J, Takacs, J, Fulop, T, Gaal, Z, Pauker, Z, Foldesi, I, Simon, J, Oroszan, T, Futo, L, Bezzegh, K, Nagy, A, Vandorfi, G, Kiss, J, Kesmarki, N, Kis, E, Papp, A, Kovacs, A, Szakal, I, Palinkas, A, Czegany, Z, Voros, P, Reiber, I, Kerenyi, Z, Dezso, E, Wittman, I, Penzes, J, Ples, Z, Taller, A, Farago, K, Kis, Jt, Zilahi, Z, Molnar, M, Barkai, L, Mileder, M, Szentpeteri, I, Peterfai, E, Lovasz, O, Mosenzon, O, Minuchin, O, Jaffe, A, Vishlitsky, V, Shimon, I, Bashkin, A, Stern, N, Elias, N, Bental, T, Butnaru, A, Lewis, B, Adawi, F, Nseir, W, Klainman, E, Herskovits, T, Cignarelli, M, Rotella, Cm, Ambrosio, G, Pozzilli, P, Genovese, S, Cavarape, A, Salvioni, A, Sokolova, J, Strautina, I, Teterovska, D, Stalte, V, Pastare, S, Leitane, I, Lagzdina, L, Andersone, I, Eglite, R, Stelmane, I, Levinger, A, Barsiene, L, Sulskiene, M, Varanauskiene, E, Danyte, E, Urbanaviciene, E, Urbanavicius, V, Zabuliene, L, Juskiene, R, Velaviciene, A, Kakariekiene, V, Augusteniene, A, Velickiene, D, Lasiene, J, Dauksiene, D, Caponis, J, Tan, At, Ramanathan, L, Hassan, Mra, Tan, F, Ong, Tk, Foo, Sh, Ghani, Ra, Cheah, Wk, Sanchez Mijangos JH, Cabrera Jardines, R, Barrientos Perez, M, Sauque Reyna, L, Alcocer Gamba MA, Villeda Espinosa, E, Tamez Perez HE, De La Garza Hernandez NE, Lopes, Sm, Ramirez Diaz SP, Reyes Sanchez, R, Márquez-Rodriguez, E, Köse, V, Voors-Pette, C, Oldenburg-Ligtenberg, Pc, van Kempen WW, Cox, K, Hoogendyk, J, Swinkels-Diepenmaat, L, Rojas-Lingan, G, Kentgens, S, Schipperen, S, de Valk HW, Swart, H, van Bemmel, B, Hoogslag, Pam, Diamant, M, Serné, Eh, Hamer, A, Wilson, S, Fisher, N, Dixon, P, Chaudhri, O, Crawford, V, Quinn, D, Nirmalaraj, K, Dunn, P, Gillies, J, Cutfield, R, Krebs, J, Helm, C, Kerr, J, Pryke, J, Ebo, G, Denopol, M, Ang, E, Uy, N, Jimeno, C, Mirasoi, R, Paz Pacheco, E, Custodio, M, Nicodemus, N Jr, Catindig, Ea, Magno, M, Tirador, L, Cylkowska, B, Stasinksa, T, Silwinska, T, Sroka, M, Piepiorka, M, Korzeniak, R, Mirecka, H, Zaluska, R, Pupek-Musialik, D, Homenda, W, Grabowska, A, Okopien, B, Niegowska, J, Pogorzelska, H, Mikolajczyk-Swatko, A, Sikorski, M, Sowinski, D, Tahk, Sj, Kim, Yn, Nam, Cw, Rim, Sj, Kim, Cj, Choi, Km, Lee, Ik, Kim, Ij, Namgung, J, Moon, Kw, Kim, Ks, Oh, Bh, Lee, Wy, Choi, Sh, Kim, Es, Moon, S, Mindrescu, Nm, Aron, G, Graur, M, Hancu, N, Mlitaru, C, Nafornita, V, Szilagyi, I, Popa, Ar, Angelescu, Lm, Negrisanu, Gd, Zaharie, Dg, Culman, Mi, Vacaru, G, Munteanu, M, Constantinescu, S, Tivadar, S, Dreval, A, Barbarash, O, Strongin, L, Dogadin, S, Suplotova, L, Izmozherova, N, Marasaev, V, Khokhlov, A, Repin, A, Turova, E, Bondar, I, Samoylova, Y, Sherenkov, A, Smolenskaya, O, Zrahevskiy, K, Koshelskaya, O, Obrezan, A, Dzupina, A, Stevlik, J, Buganova, I, Pella, D, Vinanska, D, Jascur, J, Micko, K, Sosovec, D, Philippiova, A, Olexa, P, Fedacko, J, Selecky, J, Nicolau, J, Mediavilla Garcia, J, Botella Serrano, M, Lecube, A, Arguelles, I, Sabán, J, Gómez Cerezo, F, Soto, A, Bellido, D, Sucunza Alfonso, N, Vendrell Ortega, J, Alvarez, L, Garcia Puig, J, Angustias Quesada, M, Contreras Gilbert, J, Almeida, Ca, Tinahones, Fj, Garcia Ortiz, L, Gómez Marcos MA, Aomar, I, Fernández Balsells, M, Distiller, L, Padayachee, T, Badat, A, Ebrahim, I, Naiker, P, Ranjith, N, Kelfkens, Y, Makan, H, Mogashoa, S, Fulat, M, Carim-Ganey, N, Coetzee, K, Govender, T, Nortje, H, Wilhase, A, Seedat, S, Gani, M, Ellis, G, Rheeder, P, Wing, J, Blignaut, S, Kaplan, H, Lottering, H, Pillai, P, Louw, C, Coetzer, T, Sheu, Whh, Chen, Jf, Yang, Cy, Tseng, St, Wang, Cy, Lai, Wt, Hung, Yj, Hsieh, Ic, Su, Sl, Pei, D, Benjasuratwong, Y, Purewal, T, Milward, A, Dimitropoulos, I, Kumar, S, Barber, T, Wiles, P, Dang, C, Adler, A, Philip, S, Bellary, S, Price, D, Oelbaum, R, Heller, S, Sathayapalan, T, Clark, J, Leese, G, Simpson, H, Kilvert, A, Dawson, A, Hall, T, Takhar, A, Bundy, C, Harvey, P, Maxwell, S, Asamoah-Owusu, Nj, Mcknight, J, Chatterjee, S, Calvert, J, Wright, A, Macrury, S, Macfarlane, D, Johnson, A, Litchfield, J, Field, B, Koval, O, Larin, O, Levchenko, O, Martynyuk, L, Maslyanko, V, Rudyk, I, Suprun, Y, Tseluyko, V, Botsyurko, V, Vatutin, M, Fushtey, I, Grishyna, O, Kuskalo, P, Panina, S, Pererva, L, Prysupa, L, Teliatnikova, Z, Sokolova, L, Vlasenko, M, Berenfus, V, Gyrina, O, Kopytsya, M, Vizir, V, Vayda, M, Shanik, M, Headapohl, D, Pahl, J, Aronoff, S, Bartkowiak, A Jr, Chang, A, Gaudiani, L, Kayne, D, Look, M, Patel, N, Moran, J, Stout, E, Tsao, J, Struble, R, Fishman, N, Rodbard, H, Lucas, K, Dugano-Daphnis, P, Merrick, B, Nadar, V, Severa, L, Sorli, C, Chang, M, Reed, J III, Grunberger, G, Bain, C, Bestermann, W Jr, Morawski, E, White, J, Azizad, M, Ukwade, P, Anekwe, A, Jimenez, A, Weiss, D, Green, S, Overcash, J, Eaton, C, Roseman, H, Soler, N, Mikell, F, Manos, P, Levinson, L, Claxton, E Jr, Weiss, R, Argoud, G, Bickel, L, Wilson, J, Short, B, Webster, B, Mcneill, R, Schnall, A, Force, R, Phillips, L, Bybee, K, Forker, A, Denham, D, Vonderhaar, T, Pullman, J, Kruger, D, Whitehouse, F, Wysham, C, Baron, M, Kravitz, A, Dushkin, H, Manning, Mb, Wine, A, Jaffrani, N, Chadha, C, Sperl-Hillen, J, Busch, R, Estevez, R, Robbins, D, Rassouli, N, Garvey, T, Oparil, S, Eckel, R, Mcdermott, M, Rasouli, N, Mcgill, J, Corder, C, Klonoff, D, Mills, R, Earl, J, Kessel, J, Cuddihy, R, Zimmerman, R, Dayamani, P, Oral, E, Zimering, M, Marks, J, Farnsworth, K, Sugimoto, D, Toth, P, Bhargava, A, Mcguire, D, Rohatgi, A, Davies, M, Peden, E, Wyne, K, Alfonso, L, Seyoum, B, Akpunonu, B, Feinglos, M, Reaven, P, Soule, J, Luttrell, L, Schactman, B, Canadas, R, Boggs, B, Abbott, L, Herring, C, Roberts, L, Hage-Korban, E, Schubart, U, Taylon, A, Tannenbaum, A, Kingsley, J, Lenhard, J, Biscoveanu, M, Cohen, J, Donovan, D, Laferrere, B, Thompson, N, Wade, T, Detweiler, R, Henson, B, White, A, Cavale, A, Ravi, C, Thomas, A, Goodman, H, Kalen, V, Fox, D, Dauber, I, Rizvi, S, Marcus, A, Mulford, M, Higgins, A, Chane, M, Bland, V, Osunkoya, A, Suresh, D, Khan, S, Anastasi, L, Bajaj, M, Eisen, H, Mudaliar, Sr, Powell, S, Carr, K, Tripathy, D, Azad, N, Wakefield, P, Acheatel, R, Bressler, P, Dean, J, El Shahawy, M, Gilbert, J, Haque, I, Humiston, D, Ison, R, Karounos, D, Lillestol, M, Ferrier, N, Labroo, A, Vo, A, D’Agostino, R, Dulin, M, Mcwilliams, A, Hargrove, J, Blumberg, E, Jackson, B, Staniloae, C, Salacata, A, Hidalgo, H Jr, Nicol, P, Digiovanna, M, Soufer, J, Mahabadi, V, Akinboboye, O, Arauz-Pacheco, C, Neutel, J, Dungan, K, Benson, M, Powell, T, Gandy, W, Rovner, S, Berk, M, Khan, A, Ledesma, G, Madu, I, Erickson, B, Radbill, M, Graves, M, Kaczmarek, G, Giep, S, Baldauf, C, Golden, G, Lesh, K, Davis, C, Godbole, N, Kirby, W, Razzaque, N, Bhatt, B, Wilson, M., Internal medicine, ACS - Diabetes & metabolism, and ACS - Microcirculation

Subjects
Male, medicine.medical_specialty, EXSCEL Study Group, Injections, Subcutaneous, 030209 endocrinology & metabolism, Type 2 diabetes, Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, Placebo, Article, Drug Administration Schedule, GLP1-agonists, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, Interquartile range, Internal medicine, Diabetes mellitus, General & Internal Medicine, medicine, Humans, Hypoglycemic Agents, Least-Squares Analysis, Aged, Glycated Hemoglobin, business.industry, Venoms, Semaglutide, Incidence, Type 2 diabetes, GLP1-agonists, exenatide, cardiovascular effects, General Medicine, 11 Medical And Health Sciences, Middle Aged, medicine.disease, Surgery, Albiglutide, Editorial, Diabetes Mellitus, Type 2, Cardiovascular Diseases, Exenatide, Dulaglutide, Female, business, Peptides, cardiovascular effects, medicine.drug
Abstract

BACKGROUND: The cardiovascular effects of adding once-weekly treatment with exenatide to usual care in patients with type 2 diabetes are unknown. METHODS: We randomly assigned patients with type 2 diabetes, with or without previous cardiovascular disease, to receive subcutaneous injections of extended-release exenatide at a dose of 2 mg or matching placebo once weekly. The primary composite outcome was the first occurrence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke. The coprimary hypotheses were that exenatide, administered once weekly, would be noninferior to placebo with respect to safety and superior to placebo with respect to efficacy. RESULTS: In all, 14,752 patients (of whom 10,782 [73.1%] had previous cardiovascular disease) were followed for a median of 3.2 years (interquartile range, 2.2 to 4.4). A primary composite outcome event occurred in 839 of 7356 patients (11.4%; 3.7 events per 100 person-years) in the exenatide group and in 905 of 7396 patients (12.2%; 4.0 events per 100 person-years) in the placebo group (hazard ratio, 0.91; 95% confidence interval [CI], 0.83 to 1.00), with the intention-to-treat analysis indicating that exenatide, administered once weekly, was noninferior to placebo with respect to safety (P

Published
2017
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33. Experimental estimation of fatigue resistance of rubber-cord composite under orthogonal to reinforcement deformation be-fore and after artificial aging

Author

Larin, O. O.

Subjects
гумові композити, старіння, експериментальні тести на втому, каркас пневматичної шини, rubber composites, aging, experimental fatigue tests, carcass layers of the pneumatic tire
Abstract

The paper defines parameters of the fatigue resistance of the rubber-base composite with textile reinforcement and the regularity of their changes due to aging. That material is presents pneumatic tire's carcass layer. The research has carried out experimentally using a modern measuring system INSTRON. Tests have been carried out with specimens on cyclic tensile uni-directional deformation in a displacement control condition. The amplitudes of deformation was fixed and the specimens cycles around the set middle level of deformation, that avoids the effect of specimen buckling. The results of the tests on cyclic deformation up to failure at different amplitudes of the load have been approximated by the straight lines in a double logarithmic coordinates, i.e. classical Wohler fatigue curves were obtained. The specimens before and after aging have been studied independently. The aging of samples was gained artificially using the procedure of thermal prolonged exposure in a heat chamber at a fixed temperature. Based on the recommendations given in the literature, the samples were kept for 6 days at 80 °C, that corresponds to the natural aging of this material at a room temperature during the 3 years. Comparative analysis of fatigue curves obtained for samples of the material before and after artificial aging shows that the slope of Wohler curves does not change over the time, but the basic number of cycles to failure is significantly reduced. The parameters of the approximations for fatigue curves are obtained relatively for the amplitudes of strains and Cauchy true stresses., В работе определяются показатели сопротивления усталости усиленного текстильным кордом резинового композита и закономерности их изменения в результате старения. Исследования проводятся экспериментально с плоскими образцами на растяжение. Отдельно исследовались образцы материала до и после старения. Старение проводилось искусственно путем длительной выдержки образцов в термокамере на фиксированной повышенной температуре. Проведен сравнительный анализ изменения параметров кривых усталости со временем в результате старения., У роботі визначаються показники опору втомі гумового композиту, що посилений армуванням текстильним кордом та закономірності їх зміни внаслідок старіння. Дослідження проводяться експериментально з плоскими зразками на розтяг із циклічним завданням деформацій. Окремо досліджувались зразки матеріал до та після старіння. Старіння задавалось штучно шляхом тривалої витримки зразків в термокамері на фіксованій підвищеній температурі. Проведено порівняльний аналіз зміни параметрів кривих утоми з часом в наслідок старіння.

Published
2016

34. DETERMINING MECHANICAL PROPERTIES OF A PRESSURE FIRE HOSE THE TYPE OF «T».

Author

Larin, O., Morozov, О., Nazarenko, S., Chernobay, G., Kalynovskyi, A., Kovalenko, R., Fedulova, S., and Pustovoitov, P.

Subjects
STRETCHING of materials, ELASTICITY, HYSTERESIS loop, DEAD loads (Mechanics), MECHANICAL properties of condensed matter, CYCLIC loads, CREEP (Materials)
Abstract

Experimental research into determining the mechanical properties (elastic and dissipative) of the pressure fire hose of type «T» with an inner diameter of 66 mm under conditions of static load were presented. The experiment was conducted on the experimental setup, which makes it possible to measure force and deformation. In the course of research, a series of field experiments in stretching with the sample under conditions of static loading-unloading cycles was carried out. The tests consisted of 5 cycles (modes) of loading-unloading, which were performed with a twominute interval. Taking into consideration the experimental data, the elasticity module at stretching the material of the hose in the longitudinal (along the base) direction was determined. It was established that numerical results of mechanical properties depend on the hose loading «history », that is, in the first two load modes, elasticity modules increased and were stabilized only in the subsequent modes. The above, along with a significant reduction in residual deformations, increases the elastic properties of the fire hose material. The results of the conducted studies showed that in the first two cycles, the material demonstrates short-term creep, which gets stabilized in modes 4–5. To generalize the experimental research, the results were approximated by corresponding trend lines. The curves of the sample deformation, which under conditions of cyclic loading-unloading formed the hysteresis loops, were determined. The hysteresis loops obtained during the study showed that in the first two modes, the loop are subjected to quantitative and qualitative changes, specifically, the slope of the hysteresis loop and its area decreases. It was determined that a change of the properties of the material of the fire hose at consecutive loading-unloading deformation cycles are reversed, the gaps between the deformation cycles result in partial restoration of the mechanical characteristics, approximating them to the initial values. Relaxation time is from several hours to several days and even weeks, which depends heavily on the magnitude of the previous relative deformation. [ABSTRACT FROM AUTHOR]

Published
2019
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37. Professor Valery Zhovdak - 70thanniversary

Author

Trubayev, O. I., Larin, O. O., and Morachkovsky, O. K.

Subjects
біографічний нарис, надійність, прогнозування ресурсу, статистична динаміка, випадкові коливання, biographical essay, reliability, service life prediction, statistical dynamics, random vibration, биографический очерк, надежность, прогнозирование ресурса, статистическая динамика, случайные колебания
Abstract

The article is devoted to the memory of Professor Valery Zhovdak. It presents a brief biographical information. The paper describes some his basic scientific results, which forms the foundation of one of the most important research area developed in the department of dynamics and strength of machines of National Technical University "Kharkiv Polytechnic Institute". It deals with the development of the methods for random vibration analysis, reliability assessment and a prediction of mechanical systems lifetime. A short list of some important scientific publications of professor Zhovdakis cited., Статья посвящена 70-летию со дня рождения профессора В.А. Жовдака (9.03.46 -26.03.2009). Приведены краткие биографические сведения. Выделены основные результаты научной работы, которые позволили создать одно из важных направлений исследований на кафедре динамики и прочности машин НТУ ХПИ, связанного с разработкой методов анализа случайных колебаний, оценки надежности и прогнозирования ресурса механических систем. Представлен список некоторых важных публикаций В.А Жовдака., Стаття присвячена пам\'яті професора Жовдака В.О. Наведено короткі біографічні відомості. Виділено основні результати наукової роботи, які дозволили створити одне з важливих напрямів досліджень на кафедрі динаміки та міцності машин НТУ «ХПІ», що пов\'язане з розробкою методів аналізу випадкових коливань, оцінки надійності та прогнозування ресурсу механічних систем. Представлений перелік деяких важливих публікацій В.О. Жовдака.

Published
2016

39. Stiffness properties characterization of pneumatic tire by methods of computer-aided 3D modeling

Author

Isak, O. and Larin, O.

Subjects
пневматична шина, piecewise-toroidal coordinate system, контактное взаимодействие, finite element method, deformation, a pneumatic tire, метод скінченних елементів, деформация, деформація, финитно-тороидальная система координат, stiffness, метод конечных элементов, жорсткість, жесткость, the contact interaction, контактна взаємодія, пневматическая шина, фінітно-тороїдальна система координат, 629.3.027.52 [539.3]
Abstract

В роботі побудовано тривимірну геометричну та скінчено-елементну моделі пневматичної шини легкового автомобіля, що враховують особливості її геометрії, багатошарову структуру, ортотропію механічних властивостей у гумово-кордних шарах. Запропоновано систему фінітно-тороїдальних систем координат для завдання криволінійної ортотропії відповідним шарам. Наведено результати розрахунків пружної контактної взаємодії шини з дорожнім покриттям при різних типах навантажень: вертикальному, боковому та поздовжньому та за різних значень внутрішнього тиску. Отримано закономірності зміни переміщень (прогину чи зсуву) ободу колеса в залежності від прикладеного навантаження тобто визначені навантажувальні характеристики шини. Із отриманих результатів розраховані коефіцієнти жорсткості пневматичної шини по різним напрямам та закономірності їх зміни за різних значень внутрішнього тиску. Наведено порівняльну оцінку зміни характеру деформацій у внутрішніх шарах шини за різних типів навантажень. The purpose. The paper deals with the computer finite-elements 3D modelling of the pneumatic tires in a contact interaction with the almost rigid road surface that allowed to find the different types of tires operational stiffnesses (vertical, lateral and longitudinal). Design/methodology/approach. In the paper, it is developed a three-dimensional geometry and finite element model of the pneumatic tire, which takes into account the peculiarities of its geometry, multilayer structure and orthotropy of a mechanical properties in the rubber-cord layers. The system of piecewise-toroidal coordinates is proposed to specify the curvilinear orthotropy of the corresponding layers in the model. The calculations of the elastic contact of the tire with the road have been carried out at the different types of load: vertical, lateral and longitudinal with the different values of the internal pressure. Findings. The dependencies of the displacement (vertical compression or lateral shear) of the wheel rim on the applied loads are defined. From the obtained results, the stiffness factors in different directions were calculated and their dependence on the internal pressure value have been analyzed. Originality/value. The results can be used in the development of new tires design parameters, as well as in a computerized systems of the car movement control and stability (ABS, ESP, StabiliTrak). В работе построены трехмерные геометрическая и конечно-элементная модели пневматической шины легкового автомобиля, которые учитывает особенности ее геометрии, многослойную структуру, ортотропию механических свойств в резиново-кордных слоях. Предложена система финитно-тороидальных систем координат для задания криволинейной ортотропии соответствующим слоям. Приведены результаты расчетов упругого контактного взаимодействия шины с дорожным покрытием при различных типах нагрузок: вертикальной, боковой и продольной и при различных значениях внутреннего давления. Получены закономерности изменения перемещений (прогиба или смещения) обода колеса в зависимости от приложенной нагрузки, то есть, определены нагрузочные характеристики шины. Из полученных результатов рассчитаны коэффициенты жесткости пневматической шины по разным направлениям и закономерности их изменения при различных значениях внутреннего давления.

Published
2015

40. Reliability of the Rubber Tube of Automotive Hydraulic Braking System Under Fatigue Failures Considering Random Variation of Load and the Process of Aging of Material.

Author

Larin, O., Potopalskaya, K., and Mygushchenko, R.

Subjects
RELIABILITY in engineering, RUBBER tubes, HYDRAULIC brakes, FATIGUE cracks, MATHEMATICAL models
Abstract

This paper presents the approach for the assessing of the operational reliability of a multi-layer thick-walled tube made of rubber with textile reinforcement. The analysis of the fatigue accumulation process is carried out within the framework of the concept of the continuum mechanics of damage. The mathematical model, which takes into account the accumulation of damages in case of a random spread of the strength characteristics of the material, as well as the process of stochastic aging for the elastomeric matrix of the composite and possible random variation of the workload has been developed. In this case, the aging process is modelled as a reduction of the endurance limit of the material. In this paper, the mean equivalent strains of the tube and their possible statistical variation in operation have been investigated on the basis of the finite element method. To solve the above problems, a submodeling method has been employed in this work. The probability of non-failure operation of the tube has been determined using the methods and models proposed. The influence of the rate of the aging process on the lifetime of the tube has been estimated. [ABSTRACT FROM AUTHOR]

Published
2019
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41. Diagnostics of the main, connecting rod bearings in the crank mechanism

Author

Glemba, K. V., Gricenko, A. V., and Larin, O. N.

Subjects
the method of diagnosis, параметры давления, кривошипно-шатунный механизм, УДК 621.822.17, ГРНТИ 55.03, main and connecting rod bearings, diagnostic parameters, the technical condition, 621.822.17 [УДК 621.43], crank mechanism, car, диагностические параметры, техническое состояние, the pressure parameters, метод диагностирования, автомобиль, коренные и шатунные подшипники, diagnostics, диагностирование
Abstract

Представлены методы и средства диагностирования коренных и шатунных подшипников кривошипно-шатунного механизма автомобилей и тракторов. Проведены исследования изменения давления и расхода масла через коренные подшипники ДВС. Предложен и применен способ безразборной диагностики состояния подшипников скольжения двигателя, разработан прибор, обеспечивающий режимы нагружения подшипников. Определена связь повышения величины разности относительных эксцентриситетов на холостом ходу при увеличении отношения величин давлений без нагрузки и под нагрузкой. Подтверждено, что пропускная способность через коренной и шатунный подшипник характеризуется динамическими и статическими пропускными способностями этих узлов. При проведении экспериментальных исследований по определению связи технического состояния коренных подшипников с величиной сигнала давления был выявлен наиболее чувствительный режим – при частоте вращения коленчатого вала двигателя, близкой к частоте вращения холостого хода для двигателя ЗМЗ-4062. Изложены экспериментальные исследования. Methods and means of diagnosing main and connecting rod bearing crank drive trucks and tractors. Examined the change in pressure and fluid flow through the engine crankshaft bearings. Аpplied a method of diagnosing the state of sliding bearings indiscriminately еngine. Еstablished diagnostic device. We have established the relationship between the eccentric bearing profile and the amount of pressure with no load and under load. We confirmed that the bandwidth through the main and connecting rod bearing is characterized by dynamic and static qualities throughputs of these nodes. When conducting experimental studies on the linkage of technical condition of main bearings with the magnitude of the pressure signal was detected most sensitive mode - idle speed for the engine “ZMZ-4062”. Presents experimental studies. Глемба Константин Вячеславович. Кандидат технических наук, доцент кафедры «Эксплуатация автомобильного транспорта», Южно-Уральский государственный университет (Челябинск), glemba77@mail.ru. Гриценко Александр Владимирович. Кандидат технических наук, доцент кафедры «Эксплуатация автотранспорта и производственное обучение», Челябинская государственная агроинженерная академия, alexgrits13@mail.ru. Ларин Олег Николаевич. Доктор технических наук, профессор кафедры «Эксплуатация автомобильного транспорта», Южно-Уральский государственный университет (Челябинск), larin_on @mail.ru. K.V. Glemba, South Ural State University, Chelyabinsk, Russian Federation, glemba77@mail.ru, A.V. Gricenko, Chelyabinsk State Academy of Agroengineering, Chelyabinsk, Russian Federation, alexgrits13@mail.ru O.N. Larin, South Ural State University, Chelyabinsk, Russian Federation, larin_on@mail.ru

Published
2014

46. Diagnosis air flow sensor passenger car

Author

Gritsenko, A. V., Larin, O. N., and Glemba, K. V.

Subjects
the car, методы и средства, diagnosis, the sensor mass flow of air, diagnostic parameters, the technical condition, датчик массового расхода воздуха, УДК 621.431.73-08, ГРНТИ 55.42, диагностические параметры, техническое состояние, метод диагностирования, автомобиль, диагностирование, method of diagnosis, methods and tools
Abstract

Представлен новый метод диагностирования датчиков массового расхода воздуха автомобилей, изложены экспериментальные исследования. Showing new methods of diagnosing car air flow sensor, presents experimental studies. Гриценко Александр Владимирович. Кандидат технических наук, доцент кафедры «Эксплуатация автотранспорта и производственное обучение», Челябинская государственная агроинженерная академия. Тел.: (351) 262-13-47; alexgrits13@mail.ru. Ларин Олег Николаевич. Доктор технических наук, профессор кафедры «Эксплуатация автомобильного транспорта», Южно-Уральский государственный университет (Челябинск). Тел.: (351) 267-91-21; larin_on@mail.ru. Глемба Константин Вячеславович. Кандидат технических наук, доцент кафедры «Эксплуатация автомобильного транспорта», Южно-Уральский государственный университет (Челябинск). Тел.: (351) 267-91-21; glemba77@mail.ru. A.V. Gritsenko, Chelyabinsk State Academy of Agroengineering, Chelyabinsk, Russian Federation, alexgrits13@mail.ru, O.N. Larin, South Ural State University, Chelyabinsk, Russian Federation, larin_on@mail.ru, K.V. Glemba, South Ural State University, Chelyabinsk, Russian Federation, glemba77@mail.ru

Published
2013

47. Statistical Estimation of Residual Strength and Reliability of Corroded Pipeline Elbow Part Based on a Direct FE-Simulations.

Author

Larin, O., Potopalska, K., and Mygushchenko, R.

Subjects
RESIDUAL stresses, STRAINS & stresses (Mechanics), FINITE element method, FRACTURE mechanics, X-ray diffraction
Abstract

In this paper, the assessment of the effect of a corrosion defect, which is developing over time on the working capacity of the pipeline elbow, has been carried out. Corrosion damage models explicitly as volumetric defect on the out surface of the pipeline elbow. The zones on the damaged section of the pipeline on which the maximum stresses are localized has been defined using the finite element analysis. The estimation of the characteristics of the deformed state of a design with defect is analysed with the framework of computer simulations. On the basis of the obtained results, the probabilistic characteristics of the stresses and plastic strains have been approximated as a function of internal pressure and corrosion defect depth, such as mean value, coefficients of variation and asymmetry. Probability densities function of plasticity appearance have been found for different defect size in operation at typical loading levels. [ABSTRACT FROM AUTHOR]

Published
2018
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48. ESTIMATION OF RESIDUAL STRENGTH OF PIPELINE'S ELBOW WITH VOLUMETRIC CORROSION DEFECT, WHICH IS DEVELOPING.

Author

Larin, O. O. and Potopalska, K. E.

Subjects
PIPELINE corrosion, VOLUMETRIC analysis, FINITE element method
Abstract

Pipelines are used as one of the most practical and low cost methods for transmission of different liquid petroleum products and gases. Damage on the pipeline is capable to appear during operation due to the accumulation of fatigue and arising of corrosion. The Aim is estimation the residual strength of pipeline's elbow with volumetric surface defect development of which is modeled in time. Deformed state assessment of damaged elbow of pipelines was held in the framework of computer modeling by using finite-element method (FEM). Corrosion damage modeled explicitly as volumetric defect on the outside of the knee pipeline. Based on the results of the study the assessment of the residual strength of pipeline with increasing surface defects in operation from 10 to 45 years has been obtained. Besides, the areas in which there is localization of maximum equivalent stresses and respectively plastic deformation depending on the size of damage were defined. By obtained results may be noted that after 37 years of operation the pipelines with the corresponding defect on surface cannot withstand the maximum load. [ABSTRACT FROM AUTHOR]

Published
2017
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50. Значення активації Akt у канцерогенезі пухлин щитоподібної залози

Author

Larin, O. S., Khoperiia, V. H., and Vas’ko, V. V.

Subjects
рак щитоподібної залози, активація Akt, thyroid carcinoma, Akt activation, рак щитовидной железы, активация Akt
Abstract

An activation of Akt (proteinkinase B) is involved in the pathogenesis of sporadic and inherited cancer of the thyroid gland (CTG) in Cowden’s syndrome. Akt regulates the growth and survival of cells in a cell culture of the thyroid gland, and also influences on their motility. The object of the research was to evaluate the role of Akt in the progression of CTG. The expression of activated Akt (phosphorylated, pAkt), Akt 1, 2, and 3, and p27has been analyzed in 46 cases of CTG, 20 follicular adenomas and the normal glandular tissue. An activation of Akt has been detected in 10/10 cases of follicular carcinoma (FC), 26/26 of papillary carcinoma (PC) of the TG, 2/10 cases of a follicular variant of papillary carcinoma, in 4/66 specimens of the normal tissue of the gland in 2/10 cases of follicular adenoma. The highest immunoactivity of pAkt has been revealed in the zones of invasion, being localized in the nucleus in FC and in the cytoplasm in case of PC with the exception of the zones of the PC invasion, where it is localized both in the nucleus and cytoplasm. The immunoreactivity of Akt 1 correlates with the pAkt localization, whereas the nuclear localization of Akt is associated with the cytoplasmatic expression of p27. In vitro studies, using CTG cellular lines, have shown that the nuclear translocation of Akt and pAkt is associated with cytoplasmatic p27, cellular invasion and migration. There occurred an inhibition of the migration of cells and a transition of the localization of Akt 1, pAkt, and p27 under the influence of P13-kinase. These data are indicative of an important role of the nuclear activation of Akt 1 in the progression of CTG., Активация Akt вовлечена в патогенез спорадических и наследственных раков щитовидной железы (РЩЖ) при синдроме Коудена. В культуре клеток щитовидной железы (ЩЖ) Akt регулирует рост и выживание клеток, а также влияет на их подвижность. Целью работы было оценить роль Akt в прогрессии РЩЖ. Экспрессия активированной Akt (pAkt), Akt 1, 2 и 3, и p27 проанализирована в 46 случаях РЩЖ, 20 фолликулярных аденом и нормальной ткани железы. Активация Akt обнаружена в 10/10 фолликулярных (ФР), 26/26 папиллярных РЩЖ (ПР), и 2/10 случаях фолликулярного варианта ПР, в 4/66 случаев нормальной ткани железы и в 2/10 фолликулярных аденом. В зонах инвазии опухоли определена выраженная иммунореактивность pAkt, локализованная в ядре при ФР и в цитоплазме при ПР, за исключением зон инвазии ПР, где она локализуется и в ядре, и в цитоплазме. Иммунореактивность Akt 1 коррелирует с локализацией pAkt, а ядерная локализация pAkt связана с цитоплазматической экспрессией р27. Исследования in vitro с использованием клеточных линий РЩЖ показали, что ядерная транслокация Akt 1 и pAkt связана с цитоплазматической экспрессией p27, инвазией и миграцией клеток. Воздействие PI3-киназы тормозило миграцию клеток и переход локализации Akt 1, pAkt и р27. Эти данные свидетельствуют о важной роли ядерной активации Akt 1 в прогрессии РЩЖ., Активація Akt (протеїнкіназа B) залучена в патогенез спорадичного та спадкового раку щитоподібної залози (РЩЗ) за синдрому Коудена. У культурі клітин щитоподібної залози (ЩЗ) Akt регулює ріст і виживання клітин, а також впливає на їх рухливість. Метою роботи було оцінити роль Akt у прогресії РЩЗ. Експресію активованої Akt (фосфорильованої, pAkt), Akt 1, 2, та 3, та p27 проаналізовано в 46 випадках РЩЗ, 20 фолікулярних аденом та нормальній тканині залози. Активацію Akt виявлено в 10/10 випадках фолікулярного раку (ФР), 26/26 папілярного раку (ПР) ЩЗ, 2/10 випадках фолікулярного варіанта папілярного раку, у 4/66 зразків нормальної тканини залози та у 2/10 випадках фолікулярної аденоми. У зонах інвазії виявлена найвища імунореактивність pAkt, локалізована в ядрі за ФР та в цитоплазмі за ПР, за винятком зон інвазії ПР, де вона локалізується і в ядрі, і в цитоплазмі. Імунореактивність Akt 1 корелює із локалізацією pAkt, а ядерна локалізація pAkt пов'язана із цитоплазматичною експресією р27. У дослідженнях in vitro із використанням клітинних ліній РЩЗ показало, що ядерна транслокація Akt 1 і pAkt пов'язана із цитоплазматичною експресією p27, інвазією і міграцією клітин. Під впливом PI3-кінази відбувалося гальмування міграції клітин і переходу локалізації Akt 1, pAkt і р27. Ці дані свідчать про важливу роль ядерної активації Akt 1 у прогресії РЩЗ.

Published
2012

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