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162 results on '"Larciprete G"'

13. Rationale and design of two prospective, multicenter, observational studies on reproductive outcome in women with recurrent failures after spontaneous or assisted conception: OTTILIA and FIRST registries

Author

Villani, M., Baldini, D., Totaro, P., Larciprete, G., Kovac, M., Carone, D., Passamonti, S. M., Permunian, E. T., Bartolotti, T., Lojacono, A., Cacciola, R., Pinto, G. L., Bucherini, E., De Stefano, Valerio, Lodigiani, C., Lavopa, C., Cho, Y. S., Pizzicaroli, C., Colaizzo, D., Grandone, E., De Stefano V. (ORCID:0000-0002-5178-5827), Villani, M., Baldini, D., Totaro, P., Larciprete, G., Kovac, M., Carone, D., Passamonti, S. M., Permunian, E. T., Bartolotti, T., Lojacono, A., Cacciola, R., Pinto, G. L., Bucherini, E., De Stefano, Valerio, Lodigiani, C., Lavopa, C., Cho, Y. S., Pizzicaroli, C., Colaizzo, D., Grandone, E., and De Stefano V. (ORCID:0000-0002-5178-5827)

Abstract

Background: Spontaneous pregnancy loss and implantation failure after assisted reproductive technologies (ART) are very common occurrences. Although 50-60% of all cases remains unexplained, various predisposing factors, including thrombophilias, have been identified. Thus, the potential benefit of a prophylaxis with low-molecular-weight heparins in improving outcomes has been often investigated over the years. However, the majority of studies are observational and results from randomized clinical trials (RCTs) are inconclusive, probably due to heterogeneity and limited sample size. To cover these unmet needs and to have further data mainly based on the real-life clinical management, we designed these multicenter registries. Methods: OTTILIA (Observational sTudy on antiThrombotic prevention in thrombophILIA and pregnancy loss) and FIRST (recurrent Failures in assIsted Reproductive Techniques) registries are two prospective, multicenter, observational studies to evaluate pregnancy or ART outcomes in consecutive women with previous reproductive failures after spontaneous or assisted conception, respectively. All enrolled women are observed from their first visit after positive pregnancy test (OTTILIA) or before commencing a new ART cycle (FIRST) until the end of pregnancy or ART procedure (negative pregnancy test/end of pregnancy, if successful cycle), respectively. Data are collected by means of questionnaires and recorded in a central database. Follow-up investigations are performed during hospital stay, routine clinical follow-up visits or telephone interviews. Primary outcome is live birth rate in the OTTILIA register and clinical pregnancy rate in the FIRST. Discussion: Although RCTs are the 'gold standard' for evaluating treatment outcomes, we believe that our registries represent a valid alternative in improving knowledge on mechanisms involved in reproductive failures and supporting future clinical decisions. Trial registration: NCT 02385461, retrospectively re

Published
2019

18. Unusual Ectopic Pregnancy: Beyond the tubes

Author

Pirollo, Lma, Larciprete, G, Valli, E, Montagnoli, C, Campora, G, and Di Pierro, G

Subjects
Scar pregnancy, Ectopic pregnancy, Ovarian pregnancy, Abdominal pregnancy, Interstitial pregnancy, Cervical pregnancy, Settore MED/40 - Ginecologia e Ostetricia
Published
2017

19. Heterotopic Pregnancy, It is Such a Rare Finding?

Author

Giacomello, F, Larciprete, G, and Valenzise, H

Subjects
Coincident Pregnancy, Ovulation Induction, Heterotopic Pregnancy, Ectopic Pregnancy, Settore MED/40 - Ginecologia e Ostetricia, Assisted reproductive technologies, Coexistent pregnancy, Combined Pregnancy
Published
2016

21. P-060: OTTILIA and FIRST: two international registries of foeto-maternal prognosis in women with recurrent reproductive failures after spontaneous or assisted conception

Author

Villani, M., primary, Larciprete, G., additional, Kovac, M., additional, Martinelli, I., additional, Tamborini Permunian, E., additional, Cacciola, R., additional, Lo Pinto, G., additional, Bucherini, E., additional, De Stefano, V., additional, Lodigiani, C., additional, Bartolotti, T., additional, Totaro, P., additional, Carone, D., additional, Baldini, D., additional, Gris, J.-C., additional, Brenner, B., additional, Monreal, M., additional, and Grandone, E., additional

Published
2017
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24. Double inherited thrombophilias and adverse pregnancy outcomes: fashion or science?

Author

Larciprete, G., Rossi, F., Deaibess, T., Brienza, L., Barbati, Giulia, Romanini, E., Gioia, S., Cirese, E., G., Larciprete, F., Rossi, T., Deaibe, L., Brienza, Barbati, Giulia, E., Romanini, S., Gioia, and E., Cirese

Subjects
Adult, Abruptio Placentae, genetics, Adult, Factor V, genetics, Female, Fetal Death, genetics, Fetal Growth Retardation, genetics, Humans, Hypertension, Pregnancy-Induced, genetics, Methylenetetrahydrofolate Reductase (NADPH2), genetics, Mutation, Plasminogen Activator Inhibitor 1, genetics, Pregnancy, Pregnancy Outcome, genetics, Retrospective Studies, Thrombophilia, genetics, thrombophilias, Pregnancy, Plasminogen Activator Inhibitor 1, Humans, Thrombophilia, Fetal Death, Methylenetetrahydrofolate Reductase (NADPH2), Retrospective Studies, Fetal Growth Retardation, Pregnancy Outcome, Factor V, Hypertension, Pregnancy-Induced, Hypertension, Mutation, Female, genetic
Abstract

To determine to what extent double inherited thrombophilias are associated with adverse obstetric complications correlated with fetoplacental insufficiency, such as preeclampsia, hemolytic anemia elevated liver enzymes and low platelet count (HELLP) syndrome, gestational hypertension, fetal growth restriction (FGR), intrauterine death (ID), abruptio placentae and disseminated intravascular coagulopathy.Pregnant women coming to delivery were retrospectively divided into two groups: group A (controls) and group B (cases). Patients belonging to group B had one of the following: severe preeclampsia, HELLP syndrome, gestational hypertension, FGR, intrauterine death, abruptio placentae of disseminated intravascular coagulopathy. We detected methylenetetrahydrofolate reductase (MTHFR) A1298C, MTHFR C677T, factor V Leiden, PAI-1, mutant prothrombin G20210A, plasma homocysteine, antithrombin III, protein S and activated protein C resistance. Normal pregnant women or pregnant women with double defects were enrolled in this study.The combination of MTHFR C677T mutation with PAI-1 (5G/5G) mutation was significantly linked with the occurrence of ID. HELLP syndrome was significantly related to the simultaneous presence of factor VIII and X mutations. The combination of MTHFR C677T with factor VIII mutation and the combination of factor II and V mutations were significantly related to the occurrence of abruptio placentae. We found an association between double isoforms MTHFR mutation and FGR.It seems that some thrombophilias and a combination of thrombophilic factors carry a greater risk than others for a given adverse outcome. Further studies are needed to check the link between thrombophilic gene mutations and adverse pregnancy outcomes, such as recurrent miscarriages and deep venous thrombosis.

Published
2010

25. Could birthweight prediction models be improved by adding fetal subcutaneous tissue thickness?

Author

Larciprete, G, Di Pierro, G, Barbati, G, Deaibess, T, Jarvis, S, Valensise, Hcc, Romanini, M, Gioia, S, Arduini, D, G., Larciprete, G. D., Pierro, Barbati, Giulia, T., Deaibe, S., Jarvi, H., Valensise, M. E., Romanini, S., Gioia, and D., Arduini

Subjects
Adult, Subcutaneous Fat, Gestational Age, Algorithms, Birth Weight, Cross-Sectional Studies, Female, Humans, Infant, Newborn, Predictive Value of Tests, Pregnancy, Sensitivity and Specificity, Thigh, Ultrasonography, Prenatal, embryology/ultrasonography, Ultrasonography, methods, embryology/ultrasonography, embryology/ultrasonography, Thigh, Prenatal, Adult, Algorithms, Birth Weight, Ultrasonography, Newborn, Predictive Value of Tests, Pregnancy, Sensitivity and Specificity, Subcutaneous Fat, Infant, physiology, Cross-Sectional Studies, Female, Gestational Age, Humans, Infant, Newborn, physiology, Settore MED/40 - Ginecologia e Ostetricia
Abstract

The aims of the study were to: (i) compare the accuracy of standard ultrasonic algorithms in the estimation of fetal weight and; (ii) test two new algorithms in order to improve the global performance of birthweight prediction by adding fetal subcutaneous tissue thickness.We enrolled 398 patients who were between 34 and 42 weeks' gestation. Routine ultrasonographic biometric parameters as well as subcutaneous tissue thickness ultrasound parameters were measured. Correlation matrices between ultrasound parameters, in order to evaluate the degree of multicollinearity between these parameters, were assessed to develop a stepwise multiple regression birthweight predictive model.Contributions of single ultrasound measurements in predicting birthweight were examined, by fitting Log-transformed birthweight versus single ultrasound measurements. We found that the mid-thigh tissue area was able to significantly improve the performance of the birthweight prediction process when added to the other standard ultrasound measurements. We derived two new algorithms which appeared to be better at predicting birthweight. Furthermore there was a lower minimum absolute estimation error noted when compared to other reported formulae.Our algorithms showed that the addition of the mid-thigh tissue evaluation in birthweight prediction was valuable in comparison to birthweight prediction models which are based on routine ultrasound parameters.

Published
2008

48. Ultrasound detection of the "sliding viscera" sign promotes safer laparoscopy.

Author

Larciprete G, Valli E, Meloni P, Malandrenis I, Romanini ME, Jarvis S, Rossi F, Barbati G, Cirese E, Larciprete, Giovanni, Valli, Edoardo, Meloni, Paolo, Malandrenis, Ioannis, Romanini, Maria Elisabetta, Jarvis, Sheba, Rossi, Federica, Barbati, Giulia, and Cirese, Elio

Abstract

Study Objective: To estimate the feasibility of preoperative ultrasound evaluation of the umbilical region in patients undergoing laparoscopy with a previous history of abdominal surgery. Design: Prospective study (Canadian Task Force Classification II-1). Setting: Department of Obstetrics and Gynecology Fatebenefratelli Isola Tiberina Hospital. Patients: Twenty-five women with a previous history of open abdominal surgery (group A) and a group of 22 women with no previous history of surgery (group B) underwent dynamic ultrasound evaluation of the umbilical field. Intervention: Ultrasound Slide-By test. Results: Patients were asked to take a deep inspiratory breath, which accentuated respiratory excursion. The movement of the intraabdominal contents in a vertical fashion in relation to the abdominal wall, referred to as the "viscera slide," between the bowel and peritoneum was evaluated. Abdominal wall tissue thickness, Uracus to peritoneum thickness (UTP, mm) were also evaluated. Non parametric Mann-Whitney testing was used. No major demographic differences between the 2 study groups was noted. The abdominal wall tissue thickness was not significantly different between the 2 groups. The UTP was shorter in A group than in B group (1.5 +/- 0.3 mm vs 3.5 +/- 0.9 mm, p = .002). Absence of the "sliding viscera" sign was observed in 16 patients in group A and in 1 patient in group B. Patients with an absence of the sliding viscera sign were found to have subumbilical fibrous adhesions during laparoscopy. Conclusions: Evaluation of trocar insertion sites may be difficult and remains a challenge for peritoneal endosurgical access. We have shown that absence of the "sliding viscera" sign is more likely to be linked to subumbilical adhesions and represents a quick method for preoperative assessment. The UTP may also be a useful measurement, which requires further validation. [ABSTRACT FROM AUTHOR]

Published
2009
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50. Total body water estimation and maternal cardiac systolic function assessment in normal and gestational hypertensive pregnant women

Author

Valensise, H., Vasapollo, B., Novell, G. P., Larciprete, G., Andreoli, A., Altomare, F., Di Pierro, G., Galante, A., Arduini, D., and Antonino De Lorenzo

Subjects
Adult, Systole, Physiological, Statistics as Topic, Left, Hypertension, Pregnancy-Induced, Female, Echocardiography, Adaptation, Physiological, Body Water, Humans, Heart Function Tests, Pregnancy, Hematocrit, Atrial Function, Left, Pregnancy-Induced, Atrial Function, Hypertension, Adaptation, Settore MED/49 - Scienze Tecniche Dietetiche Applicate

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