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Longitudinal evolution of peritoneal protein loss (PPL), a reflection of hydrostatic pressure-driven leak of plasma proteins through the large-pore pathway, is not clear. Time on PD causes loss of mesothelial cells, vasculopathy, and increased thickness of the submesothelial fibrous layer. Are these structural changes associated with progressive increase of PPL, in a parallel with the rise in the D/P creatinine? The aim of the present study was to identify longitudinal changes of PPL over time. This single-center, longitudinal study included 52 peritoneal dialysis (PD) patients with a median follow-up of 26.5 months, evaluated at two different time points with a minimum interval of 6 months. Repeated measures analysis was performed using paired sample t-test or the nonparametric Wilcoxon signed-rank test, depending on the distribution. After a median interval of 15.5 months, lower levels of residual renal function and urine volume, lower Kt/V, and creatinine clearance were found. D/P creatinine and PPL were stable, but a decrease in ultrafiltration was present. Systemic inflammation, nutrition, and volume overload showed no significant change with time on PD. Analysis of a subpopulation with over 48 months between initial and subsequential assessment (n = 11) showed again no difference in inflammation, nutritional and hydration parameters from baseline, but importantly PPL decreased after more than 4 years on PD (mean difference 1.2 g/24, p = 0.033). D/P creatinine and dip of sodium remained unchanged. The absence of deleterious effects of time on PD is reassuring, pointing to the benefit of updated PD prescription, including the standard use of more biocompatible solutions towards membrane preservation and adjusted prescription avoiding overhydration and inflammation while maintaining nutritional status. After controlling for confounders, PPL may act as a biomarker of acquired venous vasculopathy, even if small pore fluid transport rates and free water transport are preserved., (© 2024 Wiley Periodicals LLC.)

Introduction: Quantification of peritoneal protein loss (PPL) may be expressed according to a timely collection (24-h measurement or 4-h PET assessment) and as a concentration. The aim of this study was to compare the quantification methods of 24-h and 4-h collections., Methods: This study included 81 prevalent peritoneal dialysis patients. Demographics and clinical and bioelectrical impedance features were registered. PPL was measured (4-h PET and 24-h results) and peritoneal protein clearance was calculated. A linear regression model was performed., Results: Age and continuous ambulatory peritoneal dialysis (compared to cycler) were positively associated with greater PPL on 24-h collections. Neither cardiovascular disease, hypertension, diabetes nor the comorbidity Charlson Index was significantly associated with PPL. There was a consistent univariable relationship with D/P creatinine, whichever sampling method was used. Only 24-h measurements of PPL correlated with body composition variables. In multiple linear regression analysis, D/P creatinine association with PPL stands out. On the other hand, 24-h determinations (in grams or clearance) were associated with overhydration. PET protein quantification was associated with peritoneal creatinine clearance., Discussion/conclusion: Different methods sign different pathophysiological pathways. PET protein loss quantification should be regarded as a marker of peritoneal membrane intrinsic permeability. Measurements of a 24-h sample might be closer to patients' clinical status and prognosis, signalizing opportunities for therapy intervention., (© 2022 S. Karger AG, Basel.)

Background and Objective: Nutritional assessment in the elderly is difficult and different from that performed in younger people. There are specific tools for that purpose, such as the Geriatric Nutritional Risk Index (GNRI). The study objective was to compare this index to the Nutritional Risk Index (NRI)., Materials and Methods: A retrospective, observational analytical study including 113 hospitalized patients over 75 years of age receiving nutritional support. Weight, height, age, length of stay, Mini Nutritional Assessment (MNA), nutrition type and duration, and occurrence of complications were collected. GNRI and NRI were calculated. Both indexes were compared to each other and with parameters measured., Results: Mean GNRI was 88.79 (SD: 13.1), mean NRI 79.96 (SD: 10.8), and mean MNA 17.49 (SD: 4.9). Complications occurred in 50.4% of patients, and 14% died. NRI and GNRI did not correlate with length of stay (R=0.136) or with length of nutrition (R=0.041). No significant correlation was seen between GNRI and complications, but a significant relationship was found with NRI. After stratification into surgical and medical patients, NRI was seen to be significantly related to complications in surgical patients only (p<0.05). GNRI was not related to complications in either surgical or medical patients., Conclusions: In hospitalized elderly patients, NRI is a better predictor of complications and may be more appropriate for assessing the risk of death than GNRI. GNRI underestimated nutritional risk as compared to NRI., (Copyright © 2010 SEEN. Published by Elsevier Espana. All rights reserved.)