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4 results on '"Lara Nicolussi Principe"'

1. Autoimmune adrenal insufficiency in children: a hint for polyglandular syndrome type 2?

Author

Marta Arrigoni, Paolo Cavarzere, Lara Nicolussi Principe, Rossella Gaudino, and Franco Antoniazzi

Subjects
Schmidt’s syndrome, Autoimmune polyglandular syndrome type 2, Primary adrenal insufficiency, Hashimoto’s thyroiditis, Case report, Pediatrics, RJ1-570
Abstract

Abstract Background Primary adrenal insufficiency (PAI) in childhood is a life-threatening disease most commonly due to impaired steroidogenesis. Differently from adulthood, autoimmune adrenalitis is a rare condition amongst PAI’s main aetiologies and could present as an isolated disorder or as a component of polyglandular syndromes, particularly type 2. As a matter of fact, autoimmune polyglandular syndrome (APS) type 2 consists of the association between autoimmune Addison’s disease, type 1 diabetes mellitus and/or Hashimoto’s disease. Case presentation We report the case of an 8-year-old girl who presented Addison’s disease and autoimmune thyroiditis at an early stage of life. The initial course of the disease was characterized by numerous crises of adrenal insufficiency, subsequently the treatment was adjusted in a tertiary hospital with improvement of disease control. Conclusions APS type 2 is a rare condition during childhood, probably because it may remain latent for long periods before resulting in the overt disease. We recommend an early detection of APS type 2 and an adequate treatment of adrenal insufficiency in a tertiary hospital. Moreover, we underline the importance of a regular follow-up in patients with autoimmune diseases, since unrevealed and incomplete forms are frequent, especially in childhood.

Published
2023
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2. Benefits of rescreening newborns of mothers affected by autoimmune hypothyroidism

Author

Paolo Cavarzere, Laura Palma, Lara Nicolussi Principe, Monica Vincenzi, Silvana Lauriola, Rossella Gaudino, Virginia Murri, Luigi Lubrano, Giuliana Rossi, Alessia Sallemi, Ermanna Fattori, Marta Camilot, and Franco Antoniazzi

Subjects
maternal autoimmune hypothyroidism, neonatal hypothyroidism, newborn screening, anti-thyroid antibodies, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Introduction: Infants of mothers with autoimmune hypothyroidism (AH) are at risk of developing late-onset hypothyroidism, often escaping at newborn screening. This condition might be caused both by the action of maternal antibodies and/or by maternal treatment. Objectives: The aim of this study is to evaluate the prevalence of AH in the mothers of children born in Veneto region, Italy, and to define what is the most appropriate management for these newborns. Methods: Newborns of six different hospitals with a mother suffering from AH and with negative neonatal screening for congenital hypothyroidism (CH) were included in the study. Between 15 and 20 days of life, we collected a serum sample for the evaluation of thyroid function (thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3)) and anti-thyroid antibodies. On the same occasion, a capillary blood sampling was performed for a second screening test. Results: Maternal AH has a prevalence of 3.5%. A total of 291 newborns were enrolled from November 2019 to May 2021. Whereas the 11.4% of infants had a slight elevated serum TSH (>6 mU/L) and required a follow-up, only 2 children presented an elevated TSH level at the second screening test. One of these, with the gland in situ, showed persistently elevated serum TSH levels and required treatment with levothyroxine. Conclusions: Maternal AH rarely caused neonatal thyroid dysfunction. We suggest to reassess newborns from mothers with AH 15 days after birth by means of a second neonatal screening test. This procedure avoids false negatives due to maternal thyroid status, is less invasive and cheaper than the serum TSH evaluation, and prevents a long follow-up.

Published
2023
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3. Benefits of rescreening newborns of mothers affected by autoimmune hypothyroidism

Author

Paolo Cavarzere, Laura Palma, Lara Nicolussi Principe, Monica Vincenzi, Silvana Lauriola, Rossella Gaudino, Virginia Murri, Luigi Lubrano, Giuliana Rossi, Alessia Sallemi, Ermanna Fattori, Marta Camilot, and Franco Antoniazzi

Subjects
maternal antibodies, newborn screening, Endocrinology, Diabetes and Metabolism, congenital hypothyroidism, autoimmune hypothyroidism, autoimmune hypothyroidism, newborn screening, maternal antibodies, congenital hypothyroidism
Abstract

Introduction Infants of mothers with autoimmune hypothyroidism (AH) are at risk of developing late-onset hypothyroidism, often escaping at newborn screening. This condition might be caused both by the action of maternal antibodies and/or by maternal treatment. Objectives The aim of this study is to evaluate the prevalence of AH in the mothers of children born in Veneto region, Italy, and to define what is the most appropriate management for these newborns. Methods Newborns of six different hospitals with a mother suffering from AH and with negative neonatal screening for congenital hypothyroidism (CH) were included in the study. Between 15 and 20 days of life, we collected a serum sample for the evaluation of thyroid function (thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3)) and anti-thyroid antibodies. On the same occasion, a capillary blood sampling was performed for a second screening test. Results Maternal AH has a prevalence of 3.5%. A total of 291 newborns were enrolled from November 2019 to May 2021. Whereas the 11.4% of infants had a slight elevated serum TSH (>6 mU/L) and required a follow-up, only 2 children presented an elevated TSH level at the second screening test. One of these, with the gland in situ, showed persistently elevated serum TSH levels and required treatment with levothyroxine. Conclusions Maternal AH rarely caused neonatal thyroid dysfunction. We suggest to reassess newborns from mothers with AH 15 days after birth by means of a second neonatal screening test. This procedure avoids false negatives due to maternal thyroid status, is less invasive and cheaper than the serum TSH evaluation, and prevents a long follow-up.

Published
2022

4. Relation between Dietary Habits, Physical Activity, and Anthropometric and Vascular Parameters in Children Attending the Primary School in the Verona South District

Author

Denise Marcon, Lorella Branz, Sara Bonafini, Angela Tagetti, Lara Nicolussi Principe, Cristiano Fava, Claudio Maffeis, Diego Alberto Ramaroli, Franco Antoniazzi, Pietro Minuz, Rossella Gaudino, Irene Bresadola, Paolo Cavarzere, and Alice Giontella

Subjects
Male, cardiovascular risk factors, obesity, hypertension, pulse wave velocity, Hemodynamics, physical activity, lcsh:TX341-641, 030204 cardiovascular system & hematology, Models, Biological, Metabolic equivalent, Article, Body Mass Index, 03 medical and health sciences, blood pressure, children, diet, 0302 clinical medicine, Environmental health, Bayesian multivariate linear regression, Surveys and Questionnaires, Medicine, Humans, 030212 general & internal medicine, Child, Pulse wave velocity, Exercise, Nutrition and Dietetics, Schools, business.industry, Data Collection, Body Weight, Feeding Behavior, Anthropometry, medicine.disease, Obesity, Physical activity level, Blood pressure, Cross-Sectional Studies, Multivariate Analysis, Linear Models, Fast Foods, Female, business, Energy Intake, lcsh:Nutrition. Foods and food supply, Food Analysis, Food Science
Abstract

The aim of this school-based study was to identify the possible association between diet and physical activity, as well as the anthropometric, vascular, and gluco-lipid parameters. We administered two validated questionnaires for diet and physical activity (Food Frequency questionnaire (FFQ), Children-Physical Activity Questionnaire (PAQ-C)) to children at four primary schools in Verona South (Verona, Italy). Specific food intake, dietary pattern, and physical activity level expressed in Metabolic Equivalent of Task (MET) and PAQ-C score were inserted in multivariate linear regression models to assess the association with anthropometric, hemodynamic, and gluco-lipid measures. Out of 309 children included in the study, 300 (age: 8.6 &plusmn, 0.7 years, male: 50%, Obese (OB): 13.6%, High blood pressure (HBP): 21.6%) compiled to the FFQ. From this, two dietary patterns were identified: &ldquo, healthy&rdquo, and &ldquo, unhealthy&rdquo, Direct associations were found between (i) &ldquo, fast food&rdquo, intake, Pulse Wave Velocity (PWV), and (ii) animal-derived fat and capillary cholesterol, while inverse associations were found between vegetable, fruit, and nut intake and capillary glucose. The high prevalence of OB and HBP and the significant correlations between some categories of food and metabolic and vascular parameters suggest the importance of life-style modification politics at an early age to prevent the onset of overt cardiovascular risk factors in childhood.

Published
2019

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