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2 results on '"Lara Machado de Oliveira Brügger"'

1. What happens when Schwann cells are exposed to Mycobacterium leprae – A systematic review

Author

Lara Machado de Oliveira Brügger, Marina Monnerat Lemos dos Santos, Flavio Alves Lara, and Bruno Siqueira Mietto

Subjects
Host-pathogen interaction, Leprosy neuropathy, Mycobacterium leprae, Peripheral nervous system, Schwann cell, Systematic review, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Mycobacterium leprae, the pathogen that causes human leprosy, has a unique affinity for infecting and persisting inside Schwann cells, the principal glia of the peripheral nervous system. Several studies have focused on this intricate host-pathogen interaction as an attempt to advance the current knowledge of the mechanisms governing nerve destruction and disease progression. However, during the chronic course of leprosy neuropathy, Schwann cells can respond to and internalize both live and dead M. leprae and bacilli-derived antigens, and this may result in divergent cellular pathobiological responses. This may also distinctly contribute to tissue degeneration, failure to repair, inflammatory reactions, and nerve fibrosis, hallmarks of the disease. Therefore, the present study systematically searched for published studies on M. leprae-Schwann cell interaction in vitro to summarize the findings and provide a focused discussion of Schwann cell dynamics following challenge with leprosy bacilli.

Published
2023
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2. Imaging markers of neurologic damage in COVID-19: a systematic review

Author

Ana Cristina Simões e Silva, Sara Tavares Araújo, Clara Tavares Araújo, Rafael Silva e Castro, Lara Machado de Oliveira Brügger, Nathália Gualberto Souza e Silva, and Debora Marques de Miranda

Subjects
Pharmacology, Drug Discovery, Organic Chemistry, Molecular Medicine, Biochemistry
Abstract

Background and Objective: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection commonly leads to neurologic manifestations. In the present review, we aimed to investigate potential neuroimaging markers of early diagnosis and prognosis of neurologic manifestations in COVID-19. Methods: Our study was registered in the Prospective Register of Systematic Reviews (PROSPERO) under the protocol CDR42021265443. Based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we selected 51 studies for whole-manuscript analysis. Results: Magnetic resonance imaging (MRI) was the most common imaging method. The pattern, sites of lesion, signs, and symptoms of neurologic injury varied. Such manifestations possibly resulted from a direct viral infection or, most likely, from indirect mechanisms including coagulation disturbances, hypoxemia, and immunological responses. Conclusion: The heterogeneity of the studies precludes any generalization of the findings. Brain MRI is the most informative imaging exam. Population studies, including the entire spectrum of COVID-19 are missing. There is still a need for future population studies evaluating neurologic manifestations of all COVID-19 severities acutely and chronically.

Published
2022

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