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5. Duration of rupture of membranes and microbiome transmission to the newborn: A prospective study.

Author

Ribère, Maïté, Lemieux‐Labonté, Virginie, Pincez, Thomas, Azria, Elie, and Lapointe, François‐Joseph

Subjects
NEWBORN infants, LONGITUDINAL method, CESAREAN section, NOSOCOMIAL infections, RIBOSOMAL RNA
Abstract

Objective: To assess whether labour variables (i.e. individuals characteristics, labour characteristics and medical interventions) impact maternal and newborn microbiomes. Design: Prospective monocentric study. Setting: Saint‐Joseph Hospital tertiary maternity unit, in Paris, France. Population: All consecutive primiparous women with a physiological pregnancy and term labour from 15 April to 1 June 2017. Methods: 16S ribosomal RNA gene sequencing of the maternal vaginal, newborn skin and newborn oral microbiomes from 58 mother–baby dyads. Main outcome measures: Analysis of the effects of 19 labour variables on the composition and diversity of these microbiomes. Results: The 19 labour variables explained a significant part of the variability in the vaginal, newborn oral and skin microbiomes (44%–67%). Strikingly, duration of rupture of membranes was the single factor that explained the greatest variability (adjusted R2: 7.7%–8.4%, p ≤ 0.002) and conditioned, by itself, the compositions of the three microbiomes under study. Long duration of rupture of membranes was specifically associated with a lower relative abundance of the Lactobacillus genus (1.7‐fold to 68‐fold reduction, p < 0.0001) as well as an increase in microbiome diversity, including genera implicated in nosocomial infections. The effects of duration of rupture of membranes were also present in newborns delivered by non‐elective caesarean section. Conclusions: Maternal and newborn microbiomes were greatly affected by labour variables. Duration of rupture of membranes, even in non‐elective caesarean sections, should be considered in epidemiological and microbiological studies, as well as in vaginal seeding practices. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Quaternary terrestrial microvertebrates from mediterranean northwestern Africa: State-of-the-art focused on recent multidisciplinary studies

Author

Stoetzel, Emmanuelle, Lalis, Aude, Nicolas, Violaine, Aulagnier, Stéphane, Benazzou, Touria, Dauphin, Yannicke, El Hajraoui, Mohammed Abdeljalil, El Hassani, Ahmed, Fahd, Soumia, Fekhaoui, Mohammed, Geigl, Eva-Maria, Lapointe, François-Joseph, Leblois, Raphaël, Ohler, Annemarie, Nespoulet, Roland, and Denys, Christiane

Published
2019
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9. Quand les bactéries font la loi : regards éthiques, épistémiques, juridiques, politiques, sociaux et techniques sur l’utilisation du microbiome humain à des fins judiciaires

Author

Affdal, Aliya, primary, Bouchard, Frédéric, additional, Marsan, Charles, additional, Mermans, Ely, additional, Mousseau, Vincent, additional, Ravitsky, Vardit, additional, Rothmayr Allison, Christine, additional, St-Georges, Simon, additional, Trudel, Pierre, additional, and Lapointe, François-Joseph, additional

Published
2023
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20. A New Efficient Method for Assessing Missing Nucleotides in DNA Sequences in the Framework of a Generic Evolutionary Model

Author

Diallo, Abdoulaye Baniré, Makarenkov, Vladimir, Blanchette, Mathieu, Lapointe, François-Joseph, Bock, H. -H., editor, Gaul, W., editor, Vichi, M., editor, Arabie, Ph., editor, Baier, D., editor, Critchley, F., editor, Decker, R., editor, Diday, E., editor, Greenacre, M., editor, Lauro, C., editor, Meulman, J., editor, Monari, P., editor, Nishisato, S., editor, Ohsumi, N., editor, Opitz, O., editor, Ritter, G., editor, Schader, M., editor, Weihs, C., editor, Batagelj, Vladimir, editor, Bock, Hans-Hermann, editor, Ferligoj, Anuška, editor, and Žiberna, Aleš, editor

Published
2006
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27. Multiple Consensus Trees

Author

Lapointe, François-Joseph, Cucumel, Guy, Bock, H.-H., editor, Gaul, W., editor, Schader, M., editor, Jajuga, Krzysztof, editor, Sokołowski, Andrzej, editor, and Bock, Hans-Hermann, editor

Published
2002
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33. For Consensus (With Branch Lengths)

Author

Lapointe, François-Joseph, Bock, H.-H., editor, Gaul, W., editor, Opitz, O., editor, Schader, M., editor, Rizzi, Alfredo, editor, Vichi, Maurizio, editor, and Bock, Hans-Hermann, editor

Published
1998
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39. Aging at Evolutionary Crossroads: Longitudinal Gene Co-expression Network Analyses of Proximal and Ultimate Causes of Aging in Bats

Author

Teulière Jérôme, Lapointe François-Joseph, Lopez Philippe, Bapteste Eric, Corel Eduardo, Bernard Guillaume, Laboratoire National de Métrologie et d’Essais (LNE), Institut de Systématique, Evolution, Biodiversité (ISYEB ), Muséum national d'Histoire naturelle (MNHN)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), and Université de Montréal (UdeM)

Subjects
longitudinal transcriptomics, [SDV]Life Sciences [q-bio], evolution of aging, antagonistic pleiotropy theory, Myotis myotis, AcademicSubjects/SCI01180, Genetics, disposable soma theory, Selection, Genetic, Molecular Biology, Gene, Ecology, Evolution, Behavior and Systematics, Selection (genetic algorithm), Discoveries, Natural selection, biology, AcademicSubjects/SCI01130, biology.organism_classification, Phenotype, Biological Evolution, Natural population growth, Evolutionary biology, Homogeneous, mutation accumulation theory, Gene co-expression network, Transcriptome
Abstract

How, when, and why do organisms, their tissues, and their cells age remain challenging issues, although researchers have identified multiple mechanistic causes of aging, and three major evolutionary theories have been developed to unravel the ultimate causes of organismal aging. A central hypothesis of these theories is that the strength of natural selection decreases with age. However, empirical evidence on when, why, and how organisms age is phylogenetically limited, especially in natural populations. Here, we developed generic comparisons of gene co-expression networks that quantify and dissect the heterogeneity of gene co-expression in conspecific individuals from different age-classes to provide topological evidence about some mechanical and fundamental causes of organismal aging. We applied this approach to investigate the complexity of some proximal and ultimate causes of aging phenotypes in a natural population of the greater mouse-eared bat Myotis myotis, a remarkably long-lived species given its body size and metabolic rate, with available longitudinal blood transcriptomes. M. myotis gene co-expression networks become increasingly fragmented with age, suggesting an erosion of the strength of natural selection and a general dysregulation of gene co-expression in aging bats. However, selective pressures remain sufficiently strong to allow successive emergence of homogeneous age-specific gene co-expression patterns, for at least 7 years. Thus, older individuals from long-lived species appear to sit at an evolutionary crossroad: as they age, they experience both a decrease in the strength of natural selection and a targeted selection for very specific biological processes, further inviting to refine a central hypothesis in evolutionary aging theories.

Published
2021

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