Search

Your search keyword '"Lapalombella, Rosa"' showing total 542 results
Start Over Author "Lapalombella, Rosa"
542 results on '"Lapalombella, Rosa"'

1. The multi-CDK inhibitor dinaciclib reverses bromo- and extra-terminal domain (BET) inhibitor resistance in acute myeloid leukemia via inhibition of Wnt/β-catenin signaling

Author

Marr, Alexander R., Halpin, Madeline, Corbin, Dominique L., Asemelash, Yerdanos, Sher, Steven, Gordon, Britten K., Whipp, Ethan C., Mitchell, Shaneice, Harrington, Bonnie K., Orwick, Shelley, Benrashid, Samon, Goettl, Virginia M., Yildiz, Vedat, Mitchell, Andrew D., Cahn, Olivia, Mims, Alice S., Larkin, Karilyn T. M., Long, Meixao, Blachly, James, Woyach, Jennifer A., Lapalombella, Rosa, and Grieselhuber, Nicole R.

Published
2024
Full Text
View/download PDF

2. Dysregulation of PRMT5 in chronic lymphocytic leukemia promotes progression with high risk of Richter’s transformation

Author

Hing, Zachary A., Walker, Janek S., Whipp, Ethan C., Brinton, Lindsey, Cannon, Matthew, Zhang, Pu, Sher, Steven, Cempre, Casey B., Brown, Fiona, Smith, Porsha L., Agostinelli, Claudio, Pileri, Stefano A., Skinner, Jordan N., Williams, Katie, Phillips, Hannah, Shaffer, Jami, Beaver, Larry P., Pan, Alexander, Shin, Kyle, Gregory, Charles T., Ozer, Gulcin H., Yilmaz, Selen A., Harrington, Bonnie K., Lehman, Amy M., Yu, Lianbo, Coppola, Vincenzo, Yan, Pearlly, Scherle, Peggy, Wang, Min, Pitis, Philip, Xu, Chaoyi, Vaddi, Kris, Chen-Kiang, Selina, Woyach, Jennifer, Blachly, James S., Alinari, Lapo, Yang, Yiping, Byrd, John C., Baiocchi, Robert A., Blaser, Bradley W., and Lapalombella, Rosa

Published
2023
Full Text
View/download PDF

3. Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia

Author

Walker, Janek S, Hing, Zachary A, Harrington, Bonnie, Baumhardt, Jordan, Ozer, Hatice Gulcin, Lehman, Amy, Giacopelli, Brian, Beaver, Larry, Williams, Katie, Skinner, Jordan N, Cempre, Casey B, Sun, Qingxiang, Shacham, Sharon, Stromberg, Benjamin R, Summers, Matthew K, Abruzzo, Lynne V, Rassenti, Laura, Kipps, Thomas J, Parikh, Sameer, Kay, Neil E, Rogers, Kerry A, Woyach, Jennifer A, Coppola, Vincenzo, Chook, Yuh Min, Oakes, Christopher, Byrd, John C, and Lapalombella, Rosa

Subjects
Rare Diseases, Lymphoma, Cancer, Genetics, Hematology, 2.1 Biological and endogenous factors, Aetiology, Animals, Epigenesis, Genetic, Female, Gene Expression Regulation, Leukemic, Humans, Karyopherins, Leukemia, Lymphocytic, Chronic, B-Cell, Male, Mice, Inbred C57BL, Models, Molecular, Mutation, Receptors, Cytoplasmic and Nuclear, Retrospective Studies, Transcriptome, XPO1, Chronic lymphocytic leukemia, Mouse model, Selinexor, Sines, Expression profiling, Mutation analysis, Cardiorespiratory Medicine and Haematology, Oncology and Carcinogenesis
Abstract

BackgroundExportin 1 (XPO1/CRM1) is a key mediator of nuclear export with relevance to multiple cancers, including chronic lymphocytic leukemia (CLL). Whole exome sequencing has identified hot-spot somatic XPO1 point mutations which we found to disrupt highly conserved biophysical interactions in the NES-binding groove, conferring novel cargo-binding abilities and forcing cellular mis-localization of critical regulators. However, the pathogenic role played by change-in-function XPO1 mutations in CLL is not fully understood.MethodsWe performed a large, multi-center retrospective analysis of CLL cases (N = 1286) to correlate nonsynonymous mutations in XPO1 (predominantly E571K or E571G; n = 72) with genetic and epigenetic features contributing to the overall outcomes in these patients. We then established a mouse model with over-expression of wildtype (wt) or mutant (E571K or E571G) XPO1 restricted to the B cell compartment (Eµ-XPO1). Eµ-XPO1 mice were then crossed with the Eµ-TCL1 CLL mouse model. Lastly, we determined crystal structures of XPO1 (wt or E571K) bound to several selective inhibitors of nuclear export (SINE) molecules (KPT-185, KPT-330/Selinexor, and KPT-8602/Eltanexor).ResultsWe report that nonsynonymous mutations in XPO1 associate with high risk genetic and epigenetic features and accelerated CLL progression. Using the newly-generated Eµ-XPO1 mouse model, we found that constitutive B-cell over-expression of wt or mutant XPO1 could affect development of a CLL-like disease in aged mice. Furthermore, concurrent B-cell expression of XPO1 with E571K or E571G mutations and TCL1 accelerated the rate of leukemogenesis relative to that of Eµ-TCL1 mice. Lastly, crystal structures of E571 or E571K-XPO1 bound to SINEs, including Selinexor, are highly similar, suggesting that the activity of this class of compounds will not be affected by XPO1 mutations at E571 in patients with CLL.ConclusionsThese findings indicate that mutations in XPO1 at E571 can drive leukemogenesis by priming the pre-neoplastic lymphocytes for acquisition of additional genetic and epigenetic abnormalities that collectively result in neoplastic transformation.

Published
2021

4. VIP152 is a selective CDK9 inhibitor with pre-clinical in vitro and in vivo efficacy in chronic lymphocytic leukemia

Author

Sher, Steven, Whipp, Ethan, Walker, Janek, Zhang, Pu, Beaver, Larry, Williams, Katie, Orwick, Shelley, Ravikrishnan, Janani, Walker, Brandi, Perry, Elizabeth, Gregory, Charles, Purcell, Matthew, Pan, Alexander, Yan, Pearlly, Alinari, Lapo, Johnson, Amy J., Frigault, Melanie M., Greer, Joy M., Hamdy, Ahmed, Izumi, Raquel, Mo, Xiaokui, Sampath, Deepa, Woyach, Jennifer, Blachly, James, Byrd, John C., and Lapalombella, Rosa

Published
2023
Full Text
View/download PDF

5. PRMT5 inhibition drives therapeutic vulnerability to combination treatment with BCL-2 inhibition in mantle cell lymphoma

Author

Brown-Burke, Fiona, Hwang, Inah, Sloan, Shelby, Hinterschied, Claire, Helmig-Mason, JoBeth, Long, Mackenzie, Chan, Wing Keung, Prouty, Alexander, Chung, Ji-Hyun, Zhang, Yang, Singh, Satishkumar, Youssef, Youssef, Bhagwat, Neha, Chen, Zhengming, Chen-Kiang, Selina, Di Liberto, Maurizio, Elemento, Olivier, Sehgal, Lalit, Alinari, Lapo, Vaddi, Kris, Scherle, Peggy, Lapalombella, Rosa, Paik, Jihye, and Baiocchi, Robert A.

Published
2023
Full Text
View/download PDF

6. PRMT5 supports multiple oncogenic pathways in mantle cell lymphoma

Author

Sloan, Shelby L., Brown, Fiona, Long, Mackenzie, Weigel, Christoph, Koirala, Shirsha, Chung, Ji-Hyun, Pray, Betsy, Villagomez, Lynda, Hinterschied, Claire, Sircar, Anuvrat, Helmig-Mason, JoBeth, Prouty, Alexander, Brooks, Eric, Youssef, Youssef, Hanel, Walter, Parekh, Samir, Chan, Wing Keung, Chen, Zhengming, Lapalombella, Rosa, Sehgal, Lalit, Vaddi, Kris, Scherle, Peggy, Chen-Kiang, Selina, Di Liberto, Maurizio, Elemento, Olivier, Meydan, Cem, Foox, Jonathan, Butler, Daniel, Mason, Christopher E., Baiocchi, Robert A., and Alinari, Lapo

Published
2023
Full Text
View/download PDF

7. Microenvironmental control of hematopoietic stem cell fate via CXCL8 and protein kinase C

Author

Binder, Vera, Li, Wantong, Faisal, Muhammad, Oyman, Konur, Calkins, Donn L., Shaffer, Jami, Teets, Emily M., Sher, Steven, Magnotte, Andrew, Belardo, Alex, Deruelle, William, Gregory, T. Charles, Orwick, Shelley, Hagedorn, Elliott J., Perlin, Julie R., Avagyan, Serine, Lichtig, Asher, Barrett, Francesca, Ammerman, Michelle, Yang, Song, Zhou, Yi, Carson, William E., Shive, Heather R., Blachly, James S., Lapalombella, Rosa, Zon, Leonard I., and Blaser, Bradley W.

Published
2023
Full Text
View/download PDF

8. Data from Acute Lymphoblastic Leukemia with Myeloid Mutations Is a High-Risk Disease Associated with Clonal Hematopoiesis

Author

Saygin, Caner, primary, Zhang, Pu, primary, Stauber, Jacob, primary, Aldoss, Ibrahim, primary, Sperling, Adam S., primary, Weeks, Lachelle D., primary, Luskin, Marlise R., primary, Knepper, Todd C., primary, Wanjari, Pankhuri, primary, Wang, Peng, primary, Lager, Angela M., primary, Fitzpatrick, Carrie, primary, Segal, Jeremy P., primary, Gharghabi, Mehdi, primary, Gurbuxani, Sandeep, primary, Venkataraman, Girish, primary, Cheng, Jason X., primary, Eisfelder, Bart J., primary, Bohorquez, Oliver, primary, Patel, Anand A., primary, Umesh Nagalakshmi, Sheethal, primary, Jayaram, Savita, primary, Odenike, Olatoyosi M., primary, Larson, Richard A., primary, Godley, Lucy A., primary, Arber, Daniel A., primary, Gibson, Christopher J., primary, Munshi, Nikhil C., primary, Marcucci, Guido, primary, Ebert, Benjamin L., primary, Greally, John M., primary, Steidl, Ulrich, primary, Lapalombella, Rosa, primary, Shah, Bijal D., primary, and Stock, Wendy, primary

Published
2024
Full Text
View/download PDF

9. Supplementary Figures 1-19 from Acute Lymphoblastic Leukemia with Myeloid Mutations Is a High-Risk Disease Associated with Clonal Hematopoiesis

Author

Saygin, Caner, primary, Zhang, Pu, primary, Stauber, Jacob, primary, Aldoss, Ibrahim, primary, Sperling, Adam S., primary, Weeks, Lachelle D., primary, Luskin, Marlise R., primary, Knepper, Todd C., primary, Wanjari, Pankhuri, primary, Wang, Peng, primary, Lager, Angela M., primary, Fitzpatrick, Carrie, primary, Segal, Jeremy P., primary, Gharghabi, Mehdi, primary, Gurbuxani, Sandeep, primary, Venkataraman, Girish, primary, Cheng, Jason X., primary, Eisfelder, Bart J., primary, Bohorquez, Oliver, primary, Patel, Anand A., primary, Umesh Nagalakshmi, Sheethal, primary, Jayaram, Savita, primary, Odenike, Olatoyosi M., primary, Larson, Richard A., primary, Godley, Lucy A., primary, Arber, Daniel A., primary, Gibson, Christopher J., primary, Munshi, Nikhil C., primary, Marcucci, Guido, primary, Ebert, Benjamin L., primary, Greally, John M., primary, Steidl, Ulrich, primary, Lapalombella, Rosa, primary, Shah, Bijal D., primary, and Stock, Wendy, primary

Published
2024
Full Text
View/download PDF

10. PP2A is a therapeutically targetable driver of cell fate decisions via a c-Myc/p21 axis in human and murine acute myeloid leukemia

Author

Goswami, Swagata, Mani, Rajeswaran, Nunes, Jessica, Chiang, Chi-Ling, Zapolnik, Kevan, Hu, Eileen, Frissora, Frank, Mo, Xiaokui, Walker, Logan A., Yan, Pearlly, Bundschuh, Ralf, Beaver, Larry, Devine, Raymond, Tsai, Yo-Ting, Ventura, Ann, Xie, Zhiliang, Chen, Min, Lapalombella, Rosa, Walker, Alison, Mims, Alice, Larkin, Karilyn, Grieselhuber, Nicole, Bennett, Chad, Phelps, Mitch, Hertlein, Erin, Behbehani, Gregory, Vasu, Sumithira, Byrd, John C., and Muthusamy, Natarajan

Published
2022
Full Text
View/download PDF

12. Genomic analysis of cellular hierarchy in acute myeloid leukemia using ultrasensitive LC-FACSeq

Author

Saygin, Caner, Hu, Eileen, Zhang, Pu, Sher, Steven, Lozanski, Arletta, Doong, Tzyy-Jye, Nicolet, Deedra, Orwick, Shelley, Labanowska, Jadwiga, Skinner, Jordan N., Cempre, Casey, Kauffman, Tierney, Goettl, Virginia M., Heerema, Nyla A., Abruzzo, Lynne, Miller, Cecelia, Lapalombella, Rosa, Behbehani, Gregory, Mims, Alice S., Larkin, Karilyn, Grieselhuber, Nicole, Walker, Alison, Bhatnagar, Bhavana, Bloomfield, Clara D., Byrd, John C., Lozanski, Gerard, and Blachly, James S.

Published
2021
Full Text
View/download PDF

14. Acute lymphoblastic leukemia with myeloid mutations is a high-risk disease associated with clonal hematopoiesis

Author

Saygin, Caner, primary, Zhang, Pu, additional, Stauber, Jacob, additional, Aldoss, Ibrahim, additional, Sperling, Adam S., additional, Weeks, Lachelle D., additional, Luskin, Marlise R., additional, Knepper, Todd C., additional, Wanjari, Pankhuri, additional, Wang, Peng, additional, Lager, Angela M., additional, Fitzpatrick, Carrie, additional, Segal, Jeremy P., additional, Gharghabi, Mehdi, additional, Gurbuxani, Sandeep, additional, Venkataraman, Girish, additional, Cheng, Jason X., additional, Eisfelder, Bart J., additional, Bohorquez, Oliver, additional, Patel, Anand A., additional, Umesh Nagalakshmi, Sheethal, additional, Jayaram, Savita, additional, Odenike, Olatoyosi M., additional, Larson, Richard A., additional, Godley, Lucy A., additional, Arber, Daniel A., additional, Gibson, Christopher J., additional, Munshi, Nikhil C., additional, Marcucci, Guido, additional, Ebert, Benjamin L., additional, Greally, John M., additional, Steidl, Ulrich, additional, Lapalombella, Rosa, additional, Shah, Bijal D., additional, and Stock, Wendy, additional

Published
2023
Full Text
View/download PDF

15. Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia

Author

Walker, Janek S., Hing, Zachary A., Sher, Steven, Cronin, James, Williams, Katie, Harrington, Bonnie, Skinner, Jordan N., Cempre, Casey B., Gregory, Charles T., Pan, Alexander, Yano, Max, Beaver, Larry P., Walker, Brandi R., Labanowska, Jadwiga M., Heerema, Nyla A., Mrózek, Krzysztof, Woyach, Jennifer A., Ruppert, Amy S., Lehman, Amy, Ozer, Hatice Gulcin, Coppola, Vincenzo, Yan, Pearlly, Byrd, John C., Blachly, James S., and Lapalombella, Rosa

Published
2021
Full Text
View/download PDF

18. Correction: Genomic analysis of cellular hierarchy in acute myeloid leukemia using ultrasensitive LC-FACSeq

Author

Saygin, Caner, Hu, Eileen, Zhang, Pu, Sher, Steven, Lozanski, Arletta, Doong, Tzyy-Jye, Nicolet, Deedra, Orwick, Shelley, Labanowska, Jadwiga, Skinner, Jordan N., Cempre, Casey, Kauffman, Tierney, Goettl, Virginia M., Heerema, Nyla A., Abruzzo, Lynne, Miller, Cecelia, Lapalombella, Rosa, Behbehani, Gregory, Mims, Alice S., Larkin, Karilyn, Grieselhuber, Nicole, Walker, Alison, Bhatnagar, Bhavana, Bloomfield, Clara D., Byrd, John C., Lozanski, Gerard, and Blachly, James S.

Published
2021
Full Text
View/download PDF

21. Targeting BTK through microRNA in chronic lymphocytic leukemia

Author

Bottoni, Arianna, Rizzotto, Lara, Lai, Tzung-Huei, Liu, Chaomei, Smith, Lisa L., Mantel, Rose, Reiff, Sean, El-Gamal, Dalia, Larkin, Karilyn, Johnson, Amy J., Lapalombella, Rosa, Lehman, Amy, Plunkett, William, Byrd, John C., Blachly, James S., Woyach, Jennifer A., and Sampath, Deepa

Published
2016
Full Text
View/download PDF

22. Data from The BTK Inhibitor ARQ 531 Targets Ibrutinib-Resistant CLL and Richter Transformation

Author

Reiff, Sean D., primary, Mantel, Rose, primary, Smith, Lisa L., primary, Greene, J.T., primary, Muhowski, Elizabeth M., primary, Fabian, Catherine A., primary, Goettl, Virginia M., primary, Tran, Minh, primary, Harrington, Bonnie K., primary, Rogers, Kerry A., primary, Awan, Farrukh T., primary, Maddocks, Kami, primary, Andritsos, Leslie, primary, Lehman, Amy M., primary, Sampath, Deepa, primary, Lapalombella, Rosa, primary, Eathiraj, Sudharshan, primary, Abbadessa, Giovanni, primary, Schwartz, Brian, primary, Johnson, Amy J., primary, Byrd, John C., primary, and Woyach, Jennifer A., primary

Published
2023
Full Text
View/download PDF

23. Data from BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor

Author

Ozer, Hatice Gulcin, primary, El-Gamal, Dalia, primary, Powell, Ben, primary, Hing, Zachary A., primary, Blachly, James S., primary, Harrington, Bonnie, primary, Mitchell, Shaneice, primary, Grieselhuber, Nicole R., primary, Williams, Katie, primary, Lai, Tzung-Huei, primary, Alinari, Lapo, primary, Baiocchi, Robert A., primary, Brinton, Lindsey, primary, Baskin, Elizabeth, primary, Cannon, Matthew, primary, Beaver, Larry, primary, Goettl, Virginia M., primary, Lucas, David M., primary, Woyach, Jennifer A., primary, Sampath, Deepa, primary, Lehman, Amy M., primary, Yu, Lianbo, primary, Zhang, Jiazhong, primary, Ma, Yan, primary, Zhang, Ying, primary, Spevak, Wayne, primary, Shi, Songyuan, primary, Severson, Paul, primary, Shellooe, Rafe, primary, Carias, Heidi, primary, Tsang, Garson, primary, Dong, Ken, primary, Ewing, Todd, primary, Marimuthu, Adhirai, primary, Tantoy, Christina, primary, Walters, Jason, primary, Sanftner, Laura, primary, Rezaei, Hamid, primary, Nespi, Marika, primary, Matusow, Bernice, primary, Habets, Gaston, primary, Ibrahim, Prabha, primary, Zhang, Chao, primary, Mathé, Ewy A., primary, Bollag, Gideon, primary, Byrd, John C., primary, and Lapalombella, Rosa, primary

Published
2023
Full Text
View/download PDF

24. Suppl Table 2 from The BTK Inhibitor ARQ 531 Targets Ibrutinib-Resistant CLL and Richter Transformation

Author

Reiff, Sean D., primary, Mantel, Rose, primary, Smith, Lisa L., primary, Greene, J.T., primary, Muhowski, Elizabeth M., primary, Fabian, Catherine A., primary, Goettl, Virginia M., primary, Tran, Minh, primary, Harrington, Bonnie K., primary, Rogers, Kerry A., primary, Awan, Farrukh T., primary, Maddocks, Kami, primary, Andritsos, Leslie, primary, Lehman, Amy M., primary, Sampath, Deepa, primary, Lapalombella, Rosa, primary, Eathiraj, Sudharshan, primary, Abbadessa, Giovanni, primary, Schwartz, Brian, primary, Johnson, Amy J., primary, Byrd, John C., primary, and Woyach, Jennifer A., primary

Published
2023
Full Text
View/download PDF

25. Suppl Figure 1 from The BTK Inhibitor ARQ 531 Targets Ibrutinib-Resistant CLL and Richter Transformation

Author

Reiff, Sean D., primary, Mantel, Rose, primary, Smith, Lisa L., primary, Greene, J.T., primary, Muhowski, Elizabeth M., primary, Fabian, Catherine A., primary, Goettl, Virginia M., primary, Tran, Minh, primary, Harrington, Bonnie K., primary, Rogers, Kerry A., primary, Awan, Farrukh T., primary, Maddocks, Kami, primary, Andritsos, Leslie, primary, Lehman, Amy M., primary, Sampath, Deepa, primary, Lapalombella, Rosa, primary, Eathiraj, Sudharshan, primary, Abbadessa, Giovanni, primary, Schwartz, Brian, primary, Johnson, Amy J., primary, Byrd, John C., primary, and Woyach, Jennifer A., primary

Published
2023
Full Text
View/download PDF

26. Supplemental Methods from The BTK Inhibitor ARQ 531 Targets Ibrutinib-Resistant CLL and Richter Transformation

Author

Reiff, Sean D., primary, Mantel, Rose, primary, Smith, Lisa L., primary, Greene, J.T., primary, Muhowski, Elizabeth M., primary, Fabian, Catherine A., primary, Goettl, Virginia M., primary, Tran, Minh, primary, Harrington, Bonnie K., primary, Rogers, Kerry A., primary, Awan, Farrukh T., primary, Maddocks, Kami, primary, Andritsos, Leslie, primary, Lehman, Amy M., primary, Sampath, Deepa, primary, Lapalombella, Rosa, primary, Eathiraj, Sudharshan, primary, Abbadessa, Giovanni, primary, Schwartz, Brian, primary, Johnson, Amy J., primary, Byrd, John C., primary, and Woyach, Jennifer A., primary

Published
2023
Full Text
View/download PDF

27. Supplementary Methods from BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor

Author

Ozer, Hatice Gulcin, primary, El-Gamal, Dalia, primary, Powell, Ben, primary, Hing, Zachary A., primary, Blachly, James S., primary, Harrington, Bonnie, primary, Mitchell, Shaneice, primary, Grieselhuber, Nicole R., primary, Williams, Katie, primary, Lai, Tzung-Huei, primary, Alinari, Lapo, primary, Baiocchi, Robert A., primary, Brinton, Lindsey, primary, Baskin, Elizabeth, primary, Cannon, Matthew, primary, Beaver, Larry, primary, Goettl, Virginia M., primary, Lucas, David M., primary, Woyach, Jennifer A., primary, Sampath, Deepa, primary, Lehman, Amy M., primary, Yu, Lianbo, primary, Zhang, Jiazhong, primary, Ma, Yan, primary, Zhang, Ying, primary, Spevak, Wayne, primary, Shi, Songyuan, primary, Severson, Paul, primary, Shellooe, Rafe, primary, Carias, Heidi, primary, Tsang, Garson, primary, Dong, Ken, primary, Ewing, Todd, primary, Marimuthu, Adhirai, primary, Tantoy, Christina, primary, Walters, Jason, primary, Sanftner, Laura, primary, Rezaei, Hamid, primary, Nespi, Marika, primary, Matusow, Bernice, primary, Habets, Gaston, primary, Ibrahim, Prabha, primary, Zhang, Chao, primary, Mathé, Ewy A., primary, Bollag, Gideon, primary, Byrd, John C., primary, and Lapalombella, Rosa, primary

Published
2023
Full Text
View/download PDF

28. Suppl Table 1 from The BTK Inhibitor ARQ 531 Targets Ibrutinib-Resistant CLL and Richter Transformation

Author

Reiff, Sean D., primary, Mantel, Rose, primary, Smith, Lisa L., primary, Greene, J.T., primary, Muhowski, Elizabeth M., primary, Fabian, Catherine A., primary, Goettl, Virginia M., primary, Tran, Minh, primary, Harrington, Bonnie K., primary, Rogers, Kerry A., primary, Awan, Farrukh T., primary, Maddocks, Kami, primary, Andritsos, Leslie, primary, Lehman, Amy M., primary, Sampath, Deepa, primary, Lapalombella, Rosa, primary, Eathiraj, Sudharshan, primary, Abbadessa, Giovanni, primary, Schwartz, Brian, primary, Johnson, Amy J., primary, Byrd, John C., primary, and Woyach, Jennifer A., primary

Published
2023
Full Text
View/download PDF

29. Supplementary Figures & Tables from BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor

Author

Ozer, Hatice Gulcin, primary, El-Gamal, Dalia, primary, Powell, Ben, primary, Hing, Zachary A., primary, Blachly, James S., primary, Harrington, Bonnie, primary, Mitchell, Shaneice, primary, Grieselhuber, Nicole R., primary, Williams, Katie, primary, Lai, Tzung-Huei, primary, Alinari, Lapo, primary, Baiocchi, Robert A., primary, Brinton, Lindsey, primary, Baskin, Elizabeth, primary, Cannon, Matthew, primary, Beaver, Larry, primary, Goettl, Virginia M., primary, Lucas, David M., primary, Woyach, Jennifer A., primary, Sampath, Deepa, primary, Lehman, Amy M., primary, Yu, Lianbo, primary, Zhang, Jiazhong, primary, Ma, Yan, primary, Zhang, Ying, primary, Spevak, Wayne, primary, Shi, Songyuan, primary, Severson, Paul, primary, Shellooe, Rafe, primary, Carias, Heidi, primary, Tsang, Garson, primary, Dong, Ken, primary, Ewing, Todd, primary, Marimuthu, Adhirai, primary, Tantoy, Christina, primary, Walters, Jason, primary, Sanftner, Laura, primary, Rezaei, Hamid, primary, Nespi, Marika, primary, Matusow, Bernice, primary, Habets, Gaston, primary, Ibrahim, Prabha, primary, Zhang, Chao, primary, Mathé, Ewy A., primary, Bollag, Gideon, primary, Byrd, John C., primary, and Lapalombella, Rosa, primary

Published
2023
Full Text
View/download PDF

30. Suppl Figure 2 from The BTK Inhibitor ARQ 531 Targets Ibrutinib-Resistant CLL and Richter Transformation

Author

Reiff, Sean D., primary, Mantel, Rose, primary, Smith, Lisa L., primary, Greene, J.T., primary, Muhowski, Elizabeth M., primary, Fabian, Catherine A., primary, Goettl, Virginia M., primary, Tran, Minh, primary, Harrington, Bonnie K., primary, Rogers, Kerry A., primary, Awan, Farrukh T., primary, Maddocks, Kami, primary, Andritsos, Leslie, primary, Lehman, Amy M., primary, Sampath, Deepa, primary, Lapalombella, Rosa, primary, Eathiraj, Sudharshan, primary, Abbadessa, Giovanni, primary, Schwartz, Brian, primary, Johnson, Amy J., primary, Byrd, John C., primary, and Woyach, Jennifer A., primary

Published
2023
Full Text
View/download PDF

31. Supplementary Tables 4 and 5 from Eμ-TCL1xMyc: A Novel Mouse Model for Concurrent CLL and B-Cell Lymphoma

Author

Lucas, Fabienne, primary, Rogers, Kerry A., primary, Harrington, Bonnie K., primary, Pan, Alexander, primary, Yu, Lianbo, primary, Breitbach, Justin, primary, Bundschuh, Ralf, primary, Goettl, Virginia M., primary, Hing, Zachary A., primary, Kanga, Parviz, primary, Mantel, Rose, primary, Sampath, Deepa, primary, Smith, Lisa L., primary, Wasmuth, Ronni, primary, White, Danielle K., primary, Yan, Pearlly, primary, Byrd, John C., primary, Lapalombella, Rosa, primary, and Woyach, Jennifer A., primary

Published
2023
Full Text
View/download PDF

32. Supplementary Figure S3 from Targeting DNA Damage Repair Functions of Two Histone Deacetylases, HDAC8 and SIRT6, Sensitizes Acute Myeloid Leukemia to NAMPT Inhibition

Author

Zhang, Pu, primary, Brinton, Lindsey T., primary, Williams, Katie, primary, Sher, Steven, primary, Orwick, Shelley, primary, Tzung-Huei, Lai, primary, Mims, Alice S., primary, Coss, Christopher C., primary, Kulp, Samuel K., primary, Youssef, Youssef, primary, Chan, Wing Keung, primary, Mitchell, Shaneice, primary, Mustonen, Allison, primary, Cannon, Matthew, primary, Phillips, Hannah, primary, Lehman, Amy M., primary, Kauffman, Tierney, primary, Beaver, Larry, primary, Canfield, Daniel, primary, Grieselhuber, Nicole R., primary, Alinari, Lapo, primary, Sampath, Deepa, primary, Yan, Pearlly, primary, Byrd, John C., primary, Blachly, James S., primary, and Lapalombella, Rosa, primary

Published
2023
Full Text
View/download PDF

33. Supplementary Data from Selinexor Combined with Ibrutinib Demonstrates Tolerability and Safety in Advanced B-Cell Malignancies: A Phase I Study

Author

Stephens, Deborah M., primary, Huang, Ying, primary, Ruppert, Amy S., primary, Walker, Janek S., primary, Canfield, Daniel, primary, Cempre, Casey B., primary, Fu, Qiang, primary, Baker, Sharyn, primary, Hu, Boyu, primary, Shah, Harsh, primary, Vadeboncoeur, Renee, primary, Rogers, Kerry A., primary, Bhat, Seema, primary, Jaglowski, Samantha M., primary, Lockman, Hank, primary, Lapalombella, Rosa, primary, Byrd, John C., primary, and Woyach, Jennifer A., primary

Published
2023
Full Text
View/download PDF

34. Supplementary Figure Legend from The Proteasome Inhibitor Carfilzomib Functions Independently of p53 to Induce Cytotoxicity and an Atypical NF-κB Response in Chronic Lymphocytic Leukemia Cells

Author

Gupta, Sneha V., primary, Hertlein, Erin, primary, Lu, Yanhui, primary, Sass, Ellen J., primary, Lapalombella, Rosa, primary, Chen, Timothy L., primary, Davis, Melanie E., primary, Woyach, Jennifer A., primary, Lehman, Amy, primary, Jarjoura, David, primary, Byrd, John C., primary, and Lucas, David M., primary

Published
2023
Full Text
View/download PDF

35. Supplementary Data from Eμ-TCL1xMyc: A Novel Mouse Model for Concurrent CLL and B-Cell Lymphoma

Author

Lucas, Fabienne, primary, Rogers, Kerry A., primary, Harrington, Bonnie K., primary, Pan, Alexander, primary, Yu, Lianbo, primary, Breitbach, Justin, primary, Bundschuh, Ralf, primary, Goettl, Virginia M., primary, Hing, Zachary A., primary, Kanga, Parviz, primary, Mantel, Rose, primary, Sampath, Deepa, primary, Smith, Lisa L., primary, Wasmuth, Ronni, primary, White, Danielle K., primary, Yan, Pearlly, primary, Byrd, John C., primary, Lapalombella, Rosa, primary, and Woyach, Jennifer A., primary

Published
2023
Full Text
View/download PDF

36. Supplementary Table 1, Figure 1 from The Proteasome Inhibitor Carfilzomib Functions Independently of p53 to Induce Cytotoxicity and an Atypical NF-κB Response in Chronic Lymphocytic Leukemia Cells

Author

Gupta, Sneha V., primary, Hertlein, Erin, primary, Lu, Yanhui, primary, Sass, Ellen J., primary, Lapalombella, Rosa, primary, Chen, Timothy L., primary, Davis, Melanie E., primary, Woyach, Jennifer A., primary, Lehman, Amy, primary, Jarjoura, David, primary, Byrd, John C., primary, and Lucas, David M., primary

Published
2023
Full Text
View/download PDF

37. Data from Selinexor Combined with Ibrutinib Demonstrates Tolerability and Safety in Advanced B-Cell Malignancies: A Phase I Study

Author

Stephens, Deborah M., primary, Huang, Ying, primary, Ruppert, Amy S., primary, Walker, Janek S., primary, Canfield, Daniel, primary, Cempre, Casey B., primary, Fu, Qiang, primary, Baker, Sharyn, primary, Hu, Boyu, primary, Shah, Harsh, primary, Vadeboncoeur, Renee, primary, Rogers, Kerry A., primary, Bhat, Seema, primary, Jaglowski, Samantha M., primary, Lockman, Hank, primary, Lapalombella, Rosa, primary, Byrd, John C., primary, and Woyach, Jennifer A., primary

Published
2023
Full Text
View/download PDF

38. Data from Genetic Validation of the Protein Arginine Methyltransferase PRMT5 as a Candidate Therapeutic Target in Glioblastoma

Author

Yan, Fengting, primary, Alinari, Lapo, primary, Lustberg, Mark E., primary, Katherine Martin, Ludmila, primary, Cordero-Nieves, Hector M., primary, Banasavadi-Siddegowda, Yeshavanth, primary, Virk, Selene, primary, Barnholtz-Sloan, Jill, primary, Bell, Erica Hlavin, primary, Wojton, Jeffrey, primary, Jacob, Naduparambil K., primary, Chakravarti, Arnab, primary, Nowicki, Michal O., primary, Wu, Xin, primary, Lapalombella, Rosa, primary, Datta, Jharna, primary, Yu, Bo, primary, Gordon, Kate, primary, Haseley, Amy, primary, Patton, John T., primary, Smith, Porsha L., primary, Ryu, John, primary, Zhang, Xiaoli, primary, Mo, Xiaokui, primary, Marcucci, Guido, primary, Nuovo, Gerard, primary, Kwon, Chang-Hyuk, primary, Byrd, John C., primary, Chiocca, E. Antonio, primary, Li, Chenglong, primary, Sif, Said, primary, Jacob, Samson, primary, Lawler, Sean, primary, Kaur, Balveen, primary, and Baiocchi, Robert A., primary

Published
2023
Full Text
View/download PDF

39. Supplementary Materials, Figure Legends, and Tables from Genetic Validation of the Protein Arginine Methyltransferase PRMT5 as a Candidate Therapeutic Target in Glioblastoma

Author

Yan, Fengting, primary, Alinari, Lapo, primary, Lustberg, Mark E., primary, Katherine Martin, Ludmila, primary, Cordero-Nieves, Hector M., primary, Banasavadi-Siddegowda, Yeshavanth, primary, Virk, Selene, primary, Barnholtz-Sloan, Jill, primary, Bell, Erica Hlavin, primary, Wojton, Jeffrey, primary, Jacob, Naduparambil K., primary, Chakravarti, Arnab, primary, Nowicki, Michal O., primary, Wu, Xin, primary, Lapalombella, Rosa, primary, Datta, Jharna, primary, Yu, Bo, primary, Gordon, Kate, primary, Haseley, Amy, primary, Patton, John T., primary, Smith, Porsha L., primary, Ryu, John, primary, Zhang, Xiaoli, primary, Mo, Xiaokui, primary, Marcucci, Guido, primary, Nuovo, Gerard, primary, Kwon, Chang-Hyuk, primary, Byrd, John C., primary, Chiocca, E. Antonio, primary, Li, Chenglong, primary, Sif, Said, primary, Jacob, Samson, primary, Lawler, Sean, primary, Kaur, Balveen, primary, and Baiocchi, Robert A., primary

Published
2023
Full Text
View/download PDF

40. Supplementary Figures 1 - 7 from Genetic Validation of the Protein Arginine Methyltransferase PRMT5 as a Candidate Therapeutic Target in Glioblastoma

Author

Yan, Fengting, primary, Alinari, Lapo, primary, Lustberg, Mark E., primary, Katherine Martin, Ludmila, primary, Cordero-Nieves, Hector M., primary, Banasavadi-Siddegowda, Yeshavanth, primary, Virk, Selene, primary, Barnholtz-Sloan, Jill, primary, Bell, Erica Hlavin, primary, Wojton, Jeffrey, primary, Jacob, Naduparambil K., primary, Chakravarti, Arnab, primary, Nowicki, Michal O., primary, Wu, Xin, primary, Lapalombella, Rosa, primary, Datta, Jharna, primary, Yu, Bo, primary, Gordon, Kate, primary, Haseley, Amy, primary, Patton, John T., primary, Smith, Porsha L., primary, Ryu, John, primary, Zhang, Xiaoli, primary, Mo, Xiaokui, primary, Marcucci, Guido, primary, Nuovo, Gerard, primary, Kwon, Chang-Hyuk, primary, Byrd, John C., primary, Chiocca, E. Antonio, primary, Li, Chenglong, primary, Sif, Said, primary, Jacob, Samson, primary, Lawler, Sean, primary, Kaur, Balveen, primary, and Baiocchi, Robert A., primary

Published
2023
Full Text
View/download PDF

41. Genomic analysis of cellular hierarchy in acute myeloid leukemia using ultrasensitive LC-FACSeq

Author

Saygin, Caner, Hu, Eileen, Zhang, Pu, Sher, Steven, Lozanski, Arletta, Doong, Tzyy-Jye, Nicolet, Deedra, Orwick, Shelley, Labanowska, Jadwiga, Skinner, Jordan N., Cempre, Casey, Kauffman, Tierney, Goettl, Virginia M., Heerema, Nyla A., Abruzzo, Lynne, Miller, Cecelia, Lapalombella, Rosa, Behbehani, Gregory, Mims, Alice S., Larkin, Karilyn, Grieselhuber, Nicole, Walker, Alison, Bhatnagar, Bhavana, Bloomfield, Clara D., Byrd, John C., Lozanski, Gerard, and Blachly, James S.

Abstract

Hematopoiesis is hierarchical, and it has been postulated that acute myeloid leukemia (AML) is organized similarly with leukemia stem cells (LSCs) residing at the apex. Limited cells acquired by fluorescence activated cell sorting in tandem with targeted amplicon-based sequencing (LC-FACSeq) enables identification of mutations in small subpopulations of cells, such as LSCs. Leveraging this, we studied clonal compositions of immunophenotypically-defined compartments in AML through genomic and functional analyses at diagnosis, remission and relapse in 88 AML patients. Mutations involving DNA methylation pathways, transcription factors and spliceosomal machinery did not differ across compartments, while signaling pathway mutations were less frequent in putative LSCs. We also provide insights into TP53-mutated AML by demonstrating stepwise acquisition of mutations beginning from the preleukemic hematopoietic stem cell stage. In 10 analyzed cases, acquisition of additional mutations and del(17p) led to genetic and functional heterogeneity within the LSC pool with subclones harboring varying degrees of clonogenic potential. Finally, we use LC-FACSeq to track clonal evolution in serial samples, which can also be a powerful tool to direct targeted therapy against measurable residual disease. Therefore, studying clinically significant small subpopulations of cells can improve our understanding of AML biology and offers advantages over bulk sequencing to monitor the evolution of disease.

Published
2024
Full Text
View/download PDF

42. Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation

Author

Alinari, Lapo, Mahasenan, Kiran V., Yan, Fengting, Karkhanis, Vrajesh, Chung, Ji-Hyun, Smith, Emily M., Quinion, Carl, Smith, Porsha L., Kim, Lisa, Patton, John T., Lapalombella, Rosa, Yu, Bo, Wu, Yun, Roy, Satavisha, De Leo, Alessandra, Pileri, Stefano, Agostinelli, Claudio, Ayers, Leona, Bradner, James E., Chen-Kiang, Selina, Elemento, Olivier, Motiwala, Tasneem, Majumder, Sarmila, Byrd, John C., Jacob, Samson, Sif, Said, Li, Chenglong, and Baiocchi, Robert A.

Published
2015
Full Text
View/download PDF

43. The Multi-CDK Inhibitor Dinaciclib Shows Synergistic Activity with the BET Inhibitor PLX51107 and Reverses BET Resistance through Inhibition of Canonical Wnt Signaling in Acute Myeloid Leukemia (AML)

Author

Marr, Alexander, primary, Karmahapatra, Soumendrakrishna, additional, Corbin, Dominique, additional, Asemelash, Yerdanos, additional, Sher, Steven, additional, Mitchell, Shaneice Renee, additional, Harrington, Bonnie K, additional, Orwick, Shelley, additional, Beaver, Larry, additional, Wasmuth, Ronni, additional, Goettl, Virginia, additional, Mims, Alice S., additional, Larkin, Karilyn T., additional, Vasu, Sumithira, additional, Long, Meixiao, additional, Blachly, James S., additional, Garzon, Ramiro, additional, Byrd, John C., additional, Lapalombella, Rosa, additional, and Grieselhuber, Nicole, additional

Published
2022
Full Text
View/download PDF

44. Dysregulation of PRMT5 in Chronic Lymphocytic Leukemia Supports Transformation to Diffuse Large B-Cell Lymphoma

Author

Whipp, Ethan, primary, Hing, Zachary A, additional, Walker, Janek S., additional, Sher, Steven, additional, Cempre, Casey B., additional, Brown, Fiona, additional, Agostinelli, Claudio, additional, Pileri, Stefano A, additional, Williams, Katie, additional, Beaver, Larry, additional, Pan, Alexander, additional, Gregory, Charles T., additional, Yan, Pearlly S., additional, Scherle, Peggy, additional, Wang, Min, additional, Vaddi, Kris, additional, Chen-Kiang, Selina, additional, Woyach, Jennifer A., additional, Blachly, James S., additional, Alinari, Lapo, additional, Yang, Yiping, additional, Baiocchi, Robert A., additional, Blaser, Bradley W, additional, and Lapalombella, Rosa, additional

Published
2022
Full Text
View/download PDF

45. Genome-Wide CRISPR/Cas9 Knockout Screen Reveals Novel Gilteritinib Combinations Targeting Oxidative Phosphorylation and De-Novo Purine Biosynthesis Pathways for FLT3-ITD+ Acute Myeloid Leukemia

Author

Sher, Steven, primary, Zhang, Pu, additional, Brinton, Lindsey, additional, Gharghabi, Mehdi, additional, Williams, Katie, additional, Cannon, Matthew, additional, Walker, Janek S., additional, Canfield, Daniel, additional, Beaver, Larry, additional, Cempre, Casey B., additional, Phillips, Hannah, additional, Chen, Xuyong, additional, Yan, Pearlly S., additional, Lehman, Amy M., additional, Scherle, Peggy, additional, Wang, Min, additional, Vaddi, Kris, additional, Baiocchi, Robert A., additional, Wang, Ruoning, additional, Sampath, Deepa, additional, Alinari, Lapo, additional, Blachly, James S., additional, and Lapalombella, Rosa, additional

Published
2022
Full Text
View/download PDF

46. Constitutive PRMT5 Expression Drives Spontaneous Lymphoblastic Lymphoma In Vivo

Author

Villagomez, Lynda, primary, Smith, Porsha, additional, Yan, Fengting, additional, Chen, Victor, additional, Sloan, Shelby, additional, Patton, John T., additional, Long, Mackenzie, additional, Brown, Fiona, additional, Ahmed, Elshafa H., additional, Muthusamy, Natarajan, additional, Coppola, Vincenzo, additional, Mishra, Anjali, additional, Vaddi, Kris, additional, Scherle, Peggy, additional, Lapalombella, Rosa, additional, Alinari, Lapo, additional, and Baiocchi, Robert A., additional

Published
2022
Full Text
View/download PDF

47. LP-118, a Selective Bcl-2 Inhibitor with Tuned Bcl-Xl Activity, Causes Myeloid Differentiation and Cell Death in Acute Myeloid Leukemia (AML)

Author

Koenig, Kristin L, primary, Brame, Colin, additional, Sher, Steven, additional, Beaver, Larry, additional, Cempre, Casey B., additional, Williams, Katie, additional, Purcell, Matthew, additional, Harrington, Bonnie, additional, Chen, Yi, additional, Tan, Felai, additional, Anthony, Stephen P., additional, Chen, Yu, additional, Shen, Yue, additional, Byrd, John C., additional, and Lapalombella, Rosa, additional

Published
2022
Full Text
View/download PDF

48. VIP152 is a selective CDK9 inhibitor with pre-clinical in vitro and in vivo efficacy in chronic lymphocytic leukemia

Author

Sher, Steven, primary, Whipp, Ethan, additional, Walker, Janek, additional, Zhang, Pu, additional, Beaver, Larry, additional, Williams, Katie, additional, Orwick, Shelley, additional, Ravikrishnan, Janani, additional, Walker, Brandi, additional, Perry, Elizabeth, additional, Gregory, Charles, additional, Purcell, Matthew, additional, Pan, Alexander, additional, Yan, Pearlly, additional, Alinari, Lapo, additional, Johnson, Amy J., additional, Frigault, Melanie M., additional, Greer, Joy M., additional, Hamdy, Ahmed, additional, Izumi, Raquel, additional, Mo, Xiaokui, additional, Sampath, Deepa, additional, Woyach, Jennifer, additional, Blachly, James, additional, Byrd, John C., additional, and Lapalombella, Rosa, additional

Published
2022
Full Text
View/download PDF

49. Targeting OXPHOS de novo purine synthesis as the nexus of FLT3 inhibitor–mediated synergistic antileukemic actions

Author

Zhang, Pu, primary, Brinton, Lindsey T., additional, Gharghabi, Mehdi, additional, Sher, Steven, additional, Williams, Katie, additional, Cannon, Matthew, additional, Walker, Janek S., additional, Canfield, Daniel, additional, Beaver, Larry, additional, Cempre, Casey B., additional, Phillips, Hannah, additional, Chen, Xuyong, additional, Yan, Pearlly, additional, Lehman, Amy, additional, Scherle, Peggy, additional, Wang, Min, additional, Vaddi, Kris, additional, Baiocchi, Robert, additional, Wang, Ruoning, additional, Sampath, Deepa, additional, Alinari, Lapo, additional, Blachly, James S., additional, and Lapalombella, Rosa, additional

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results