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273 results on '"Laouali, Nasser"'

3. Hepatic steatosis, metabolic dysfunction and risk of mortality: findings from a multinational prospective cohort study

Author

Mayén, Ana-Lucia, Sabra, Mirna, Aglago, Elom K., Perlemuter, Gabriel, Voican, Cosmin, Ramos, Ines, Debras, Charlotte, Blanco, Jessica, Viallon, Vivian, Ferrari, Pietro, Olsen, Anja, Tjønneland, Anne, Langmann, Fie, Dahm, Christina C., Rothwell, Joseph, Laouali, Nasser, Marques, Chloé, Schulze, Matthias B., Katzke, Verena, Kaaks, Rudolf, Palli, Domenico, Macciotta, Alessandra, Panico, Salvatore, Tumino, Rosario, Agnoli, Claudia, Farràs, Marta, Molina-Montes, Esther, Amiano, Pilar, Chirlaque, María-Dolores, Castilla, Jesús, Werner, Mårten, Bodén, Stina, Heath, Alicia K., Tsilidis, Kostas, Aune, Dagfinn, Weiderpass, Elisabete, Freisling, Heinz, Gunter, Marc J., and Jenab, Mazda

Published
2024
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9. Associations between dietary inflammatory scores and biomarkers of inflammation in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author

Lécuyer, Lucie, Laouali, Nasser, Viallon, Vivian, Artaud, Fanny, Hébert, James R., Shivappa, Nitin, Agudo, Antonio, Tjønneland, Anne, Mellemkjær, Lene, Kaaks, Rudolf, Katzke, Verena A., Schulze, Matthias B., Frenoy, Pauline, Mancini, Francesca Romana, De Magistris, Maria Santucci, Macciotta, Alessandra, Masala, Giovanna, Agnoli, Claudia, Tumino, Rosario, Boer, Jolanda M.A., Verschuren, W.M. Monique, Enget Jensen, Torill M., Olsen, Karina Standahl, Skeie, Guri, Chirlaque, María-Dolores, Petrova, Dafina, Castro-Espin, Carlota, Quirós, J. Ramón, Guevara, Marcela, Amiano, Pilar, Borné, Yan, Sandström, Maria, Nilsson, Lena Maria, Heath, Alicia K., Mayen, Ana-Lucia, Huybrechts, Inge, Weiderpass, Elisabete, Boutron-Ruault, Marie-Christine, Dossus, Laure, Rinaldi, Sabina, and Truong, Thérèse

Published
2023
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10. Inflammatory potential of the diet and association with risk of differentiated thyroid cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author

Lécuyer, Lucie, Laouali, Nasser, Dossus, Laure, Shivappa, Nitin, Hébert, James R., Agudo, Antonio, Tjonneland, Anne, Halkjaer, Jytte, Overvad, Kim, Katzke, Verena A., Le Cornet, Charlotte, Schulze, Matthias B., Jannasch, Franziska, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Dragna, Luca, Iannuzzo, Gabriella, Jensen, Torill Enget, Brustad, Magritt, Skeie, Guri, Zamora-Ros, Raul, Rodriguez-Barranco, Miguel, Amiano, Pilar, Chirlaque, María-Dolores, Ardanaz, Eva, Almquist, Martin, Sonestedt, Emily, Sandström, Maria, Nilsson, Lena Maria, Weiderpass, Elisabete, Huybrechts, Inge, Rinaldi, Sabina, Boutron-Ruault, Marie-Christine, and Truong, Thérèse

Published
2022
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11. A longitudinal evaluation of alcohol intake throughout adulthood and colorectal cancer risk

Author

Mayén, Ana-Lucia, Viallon, Vivian, Botteri, Edoardo, Proust-Lima, Cecile, Bagnardi, Vincenzo, Batista, Veronica, Cross, Amanda J., Laouali, Nasser, MacDonald, Conor J., Severi, Gianluca, Katzke, Verena, Bergmann, Manuela M., Schulze, Mattias B., Tjønneland, Anne, Eriksen, Anne Kirstine, Dahm, Christina C., Antoniussen, Christian S., Jakszyn, Paula, Sánchez, Maria-Jose, Amiano, Pilar, Colorado-Yohar, Sandra M., Ardanaz, Eva, Travis, Ruth, Palli, Domenico, Sabina, Sieri, Tumino, Rosario, Ricceri, Fulvio, Panico, Salvatore, Bueno-de-Mesquita, Bas, Derksen, Jeroen W. G., Sonestedt, Emily, Winkvist, Anna, Harlid, Sophia, Braaten, Tonje, Gram, Inger Torhild, Lukic, Marko, Jenab, Mazda, Riboli, Elio, Freisling, Heinz, Weiderpass, Elisabete, Gunter, Marc J., and Ferrari, Pietro

Published
2022
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13. Adapted dietary inflammatory index and differentiated thyroid carcinoma risk in two French population-based case–control studies

Author

Lécuyer, Lucie, Laouali, Nasser, Hajji-Louati, Mariem, Paquet, Melanie, Souchard, Vincent, Karimi, Mojgan, Schvartz, Claire, Guizard, Anne-Valérie, Xhaard, Constance, Rubino, Carole, Ren, Yan, Borson-Chazot, Françoise, Adjadj, Elisabeth, Cordina-Duverger, Emilie, De Vathaire, Florent, Guénel, Pascal, Boutron-Ruault, Marie-Christine, and Truong, Thérèse

Published
2022
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14. Factors associated with serum ferritin levels and iron excess: results from the EPIC-EurGast study

Author

Iglesias-Vázquez, Lucía, Arija, Victoria, Aranda, Núria, Aglago, Elom K., Cross, Amanda J., Schulze, Matthias B., Quintana Pacheco, Daniel, Kühn, Tilman, Weiderpass, Elisabete, Tumino, Rosario, Redondo-Sánchez, Daniel, de Magistris, Maria Santucci, Palli, Domenico, Ardanaz, Eva, Laouali, Nasser, Sonestedt, Emily, Drake, Isabel, Rizzolo, Lucía, Santiuste, Carmen, Sacerdote, Carlotta, Quirós, Ramón, Amiano, Pilar, Agudo, Antonio, and Jakszyn, Paula

Published
2022
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15. Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition

Author

Breeur, Marie, Ferrari, Pietro, Dossus, Laure, Jenab, Mazda, Johansson, Mattias, Rinaldi, Sabina, Travis, Ruth C., His, Mathilde, Key, Tim J., Schmidt, Julie A., Overvad, Kim, Tjønneland, Anne, Kyrø, Cecilie, Rothwell, Joseph A., Laouali, Nasser, Severi, Gianluca, Kaaks, Rudolf, Katzke, Verena, Schulze, Matthias B., Eichelmann, Fabian, Palli, Domenico, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Bueno-de-Mesquita, Bas, Olsen, Karina Standahl, Sandanger, Torkjel Manning, Nøst, Therese Haugdahl, Quirós, J. Ramón, Bonet, Catalina, Barranco, Miguel Rodríguez, Chirlaque, María-Dolores, Ardanaz, Eva, Sandsveden, Malte, Manjer, Jonas, Vidman, Linda, Rentoft, Matilda, Muller, David, Tsilidis, Kostas, Heath, Alicia K., Keun, Hector, Adamski, Jerzy, Keski-Rahkonen, Pekka, Scalbert, Augustin, Gunter, Marc J., and Viallon, Vivian

Published
2022
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20. Association of plasma biomarkers of fruit and vegetable intake with incident type 2 diabetes : InterAct case-cohort study in eight European countries

Author

Zheng, Ju-Sheng, Sharp, Stephen J, Imamura, Fumiaki, Chowdhury, Rajiv, Gundersen, Thomas E, Steur, Marinka, Sluijs, Ivonne, van der Schouw, Yvonne T, Agudo, Antonio, Aune, Dagfinn, Barricarte, Aurelio, Boeing, Heiner, Chirlaque, María-Dolores, Dorronsoro, Miren, Freisling, Heinz, El-Fatouhi, Douae, Franks, Paul W, Fagherazzi, Guy, Grioni, Sara, Gunter, Marc J, Kyrø, Cecilie, Katzke, Verena, Kühn, Tilman, Khaw, Kay-Tee, Laouali, Nasser, Masala, Giovanna, Nilsson, Peter M, Overvad, Kim, Panico, Salvatore, Papier, Keren, Quirós, J Ramón, Rolandsson, Olov, Redondo-Sánchez, Daniel, Ricceri, Fulvio, Schulze, Matthias B, Spijkerman, Annemieke M W, Tjønneland, Anne, Tong, Tammy Y N, Tumino, Rosario, Weiderpass, Elisabete, Danesh, John, Butterworth, Adam S, Riboli, Elio, Forouhi, Nita G, and Wareham, Nicholas J

Published
2020

26. Childhood and adulthood passive and active smoking, and the ABO group as risk factors for pancreatic cancer in women

Author

Vedie, Anne‐Laure, Laouali, Nasser, Gelot, Amandine, Severi, Gianluca, Boutron‐Ruault, Marie‐Christine, and Rebours, Vinciane

Abstract

Active smoking and the A blood group are associated with pancreatic adenocarcinoma (PC) risk. However, potential interactions between those risk factors and the role of passive smoking have been little investigated. We aimed to explore specific and joint associations of passive and active smoking, and effect modification by the ABO blood group in French women. The study included 96,594 women from the E3N prospective cohort, mean age: 49 years (SD 6.7). Information on active and passive smoking was reported at inclusion and throughout follow‐up. Cases were classified according to the International Classification of Diseases 10. Associations with passive and active smoking and effect modification by the ABO blood group were investigated with multivariable Cox regression models to estimate hazard ratios (HR) and 95% confidence intervals (CI). During a 24‐year median follow‐up, 346 incident PC cases were identified. Current smoking compared with never and former smoking (HR 1.51 [95% CI 1.08–2.10]), and passive smoking in childhood compared with no childhood exposure (HR 1.47 [95% CI 1.08–2.00]) were associated with increased PC risk, but not passive exposure in adulthood (HR 1.16 [95% CI 0.91–1.47]). Exposure to both passive smoking in childhood and current smoking was associated with a stronger risk (HR 2.80 [95% CI 1.42–5.52]) than exposure to both current smoking and passive smoking only in adulthood (HR 1.68 [95% CI 1.10–2.57]) compared with neither passive nor active smoking. Associations between active smoking and PC risk were strongest in the O or B groups, while associations with passive smoking were strongest in the A or AB blood groups, but the interaction terms were not statistically significant. Both current smoking and passive smoking in childhood were associated with PC risk, with a maximal risk of current smokers exposed to passive smoking during childhood. Possible interactions between blood groups and active or passive smoking must be investigated in a larger series.

Published
2024
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31. Changes in lifestyle and risk of colorectal cancer in the european prospective investigation into cancer and nutrition

Author

Botteri, Edoardo, Peveri, Giulia, Berstad, Paula, Bagnardi, Vincenzo, Chen, Sairah L.F., Sandanger, Torkjel M., Hoff, Geir, Dahm, Christina C., Antoniussen, Christian S., Tjønneland, Anne, Eriksen, Anne Kirstine, Skeie, Guri, Perez-Cornago, Aurora, Huerta, José María, Jakszyn, Paula, Harlid, Sophia, Sundström, Björn, Barricarte, Aurelio, Monninkhof, Evelyn M., Derksen, Jeroen W.G., Schulze, Matthias B., Bueno-De-Mesquita, Bas, Sánchez, Maria-Jose, Cross, Amanda J., Tsilidis, Konstantinos K., De Magistris, Maria Santucci, Kaaks, Rudolf, Katzke, Verena, Rothwell, Joseph A., Laouali, Nasser, Severi, Gianluca, Amiano, Pilar, Contiero, Paolo, Sacerdote, Carlotta, Goldberg, Marcel, Touvier, Mathilde, Freisling, Heinz, Viallon, Vivian, Weiderpass, Elisabete, Riboli, Elio, Gunter, Marc J., Jenab, Mazda, Ferrari, Pietro, Botteri, Edoardo, Peveri, Giulia, Berstad, Paula, Bagnardi, Vincenzo, Chen, Sairah L.F., Sandanger, Torkjel M., Hoff, Geir, Dahm, Christina C., Antoniussen, Christian S., Tjønneland, Anne, Eriksen, Anne Kirstine, Skeie, Guri, Perez-Cornago, Aurora, Huerta, José María, Jakszyn, Paula, Harlid, Sophia, Sundström, Björn, Barricarte, Aurelio, Monninkhof, Evelyn M., Derksen, Jeroen W.G., Schulze, Matthias B., Bueno-De-Mesquita, Bas, Sánchez, Maria-Jose, Cross, Amanda J., Tsilidis, Konstantinos K., De Magistris, Maria Santucci, Kaaks, Rudolf, Katzke, Verena, Rothwell, Joseph A., Laouali, Nasser, Severi, Gianluca, Amiano, Pilar, Contiero, Paolo, Sacerdote, Carlotta, Goldberg, Marcel, Touvier, Mathilde, Freisling, Heinz, Viallon, Vivian, Weiderpass, Elisabete, Riboli, Elio, Gunter, Marc J., Jenab, Mazda, and Ferrari, Pietro

Abstract

Introduction: We investigated the impact of changes in lifestyle habits on colorectal cancer (CRC) risk in a multicountry European cohort. Methods: We used baseline and follow-up questionnaire data from the European Prospective Investigation into Cancer cohort to assess changes in lifestyle habits and their associations with CRC development. We calculated a healthy lifestyle index (HLI) score based on smoking status, alcohol consumption, body mass index, and physical activity collected at the 2 time points. HLI ranged from 0 (most unfavorable) to 16 (most favorable). We estimated the association between HLI changes and CRC risk using Cox regression models and reported hazard ratios (HR) with 95% confidence intervals (CI). Results: Among 295,865 participants, 2,799 CRC cases were observed over a median of 7.8 years. The median time between questionnaires was 5.7 years. Each unit increase in HLI from the baseline to the follow-up assessment was associated with a statistically significant 3% lower CRC risk. Among participants in the top tertile at baseline (HLI > 11), those in the bottom tertile at follow-up (HLI ≤ 9) had a higher CRC risk (HR 1.34; 95% CI 1.02-1.75) than those remaining in the top tertile. Among individuals in the bottom tertile at baseline, those in the top tertile at follow-up had a lower risk (HR 0.77; 95% CI 0.59-1.00) than those remaining in the bottom tertile. Discussion: Improving adherence to a healthy lifestyle was inversely associated with CRC risk, while worsening adherence was positively associated with CRC risk. These results justify and support recommendations for healthy lifestyle changes and healthy lifestyle maintenance for CRC prevention.

Published
2023
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32. Prediagnostic serum glyceraldehyde-derived advanced glycation end products and mortality among colorectal cancer patients

Author

Mao, Ziling, Baker, Jacqueline Roshelli, Takeuchi, Masayoshi, Hyogo, Hideyuki, Tjønneland, Anne, Eriksen, Anne Kirstine, Severi, Gianluca, Rothwell, Joseph, Laouali, Nasser, Katzke, Verena, Kaaks, Rudolf, Schulze, Matthias B., Palli, Domenico, Sieri, Sabina, de Magistris, Maria Santucci, Tumino, Rosario, Sacerdote, Carlotta, Derksen, Jeroen W. G., Gram, Inger T., Skeie, Guri, Sandanger, Torkjel M., Quirós, Jose Ramón, Crous-Bou, Marta, Sánchez, Maria-Jose, Amiano, Pilar, Colorado-Yohar, Sandra M., Guevara, Marcela, Harlid, Sophia, Johansson, Ingegerd, Perez-Cornago, Aurora, Freisling, Heinz, Gunter, Marc, Weiderpass, Elisabete, Heath, Alicia K., Aglago, Elom, Jenab, Mazda, Fedirko, Veronika, Mao, Ziling, Baker, Jacqueline Roshelli, Takeuchi, Masayoshi, Hyogo, Hideyuki, Tjønneland, Anne, Eriksen, Anne Kirstine, Severi, Gianluca, Rothwell, Joseph, Laouali, Nasser, Katzke, Verena, Kaaks, Rudolf, Schulze, Matthias B., Palli, Domenico, Sieri, Sabina, de Magistris, Maria Santucci, Tumino, Rosario, Sacerdote, Carlotta, Derksen, Jeroen W. G., Gram, Inger T., Skeie, Guri, Sandanger, Torkjel M., Quirós, Jose Ramón, Crous-Bou, Marta, Sánchez, Maria-Jose, Amiano, Pilar, Colorado-Yohar, Sandra M., Guevara, Marcela, Harlid, Sophia, Johansson, Ingegerd, Perez-Cornago, Aurora, Freisling, Heinz, Gunter, Marc, Weiderpass, Elisabete, Heath, Alicia K., Aglago, Elom, Jenab, Mazda, and Fedirko, Veronika

Abstract

Glyceraldehyde-derived advanced glycation end products (glycer-AGEs) could contribute to colorectal cancer development and progression due to their pro-oxidative and pro-inflammatory properties. However, the association of glycer-AGEs with mortality after colorectal cancer diagnosis has not been previously investigated. Circulating glycer-AGEs were measured by competitive ELISA. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) for associations of circulating glycer-AGEs concentrations with CRC-specific and all-cause mortality among 1034 colorectal cancer (CRC) cases identified within the European Prospective Investigation into Cancer and Nutrition (EPIC) study between 1993 and 2013. During a mean of 48 months of follow-up, 529 participants died (409 from CRC). Glycer-AGEs were statistically significantly positively associated with CRC-specific (HRQ5 vs Q1 = 1.53, 95% CI: 1.04-2.25, Ptrend =.002) and all-cause (HRQ5 vs Q1 = 1.62, 95% CI: 1.16-2.26, Ptrend <.001) mortality among individuals with CRC. There was suggestion of a stronger association between glycer-AGEs and CRC-specific mortality among patients with distal colon cancer (per SD increment: HRproximal colon = 1.02, 95% CI: 0.74-1.42; HRdistal colon = 1.51, 95% CI: 1.20-1.91; Peffect modification =.02). The highest HR was observed among CRC cases in the highest body mass index (BMI) and glycer-AGEs category relative to lowest BMI and glycer-AGEs category for both CRC-specific (HR = 1.78, 95% CI: 1.02-3.01) and all-cause mortality (HR = 2.15, 95% CI: 1.33-3.47), although no statistically significant effect modification was observed. Our study found that prediagnostic circulating glycer-AGEs are positively associated with CRC-specific and all-cause mortality among individuals with CRC. Further investigations in other populations and stratifying by tumor location and BMI are warranted.

Published
2023
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33. Associations between dietary inflammatory scores and biomarkers of inflammation in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author

Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Lécuyer, Lucie, Laouali, Nasser, Viallon, Vivian, Artaud, Fanny, Hébert, James R, Shivappa, Nitin, Agudo, Antonio, Tjønneland, Anne, Mellemkjær, Lene, Kaaks, Rudolf, Katzke, Verena A, Schulze, Matthias B, Frenoy, Pauline, Mancini, Francesca Romana, De Magistris, Maria Santucci, Macciotta, Alessandra, Masala, Giovanna, Agnoli, Claudia, Tumino, Rosario, Boer, Jolanda M A, Verschuren, W M Monique, Enget Jensen, Torill M, Olsen, Karina Standahl, Skeie, Guri, Chirlaque, María-Dolores, Petrova, Dafina, Castro-Espin, Carlota, Quirós, J Ramón, Guevara, Marcela, Amiano, Pilar, Borné, Yan, Sandström, Maria, Nilsson, Lena Maria, Heath, Alicia K, Mayen, Ana-Lucia, Huybrechts, Inge, Weiderpass, Elisabete, Boutron-Ruault, Marie-Christine, Dossus, Laure, Rinaldi, Sabina, Truong, Thérèse, Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Lécuyer, Lucie, Laouali, Nasser, Viallon, Vivian, Artaud, Fanny, Hébert, James R, Shivappa, Nitin, Agudo, Antonio, Tjønneland, Anne, Mellemkjær, Lene, Kaaks, Rudolf, Katzke, Verena A, Schulze, Matthias B, Frenoy, Pauline, Mancini, Francesca Romana, De Magistris, Maria Santucci, Macciotta, Alessandra, Masala, Giovanna, Agnoli, Claudia, Tumino, Rosario, Boer, Jolanda M A, Verschuren, W M Monique, Enget Jensen, Torill M, Olsen, Karina Standahl, Skeie, Guri, Chirlaque, María-Dolores, Petrova, Dafina, Castro-Espin, Carlota, Quirós, J Ramón, Guevara, Marcela, Amiano, Pilar, Borné, Yan, Sandström, Maria, Nilsson, Lena Maria, Heath, Alicia K, Mayen, Ana-Lucia, Huybrechts, Inge, Weiderpass, Elisabete, Boutron-Ruault, Marie-Christine, Dossus, Laure, Rinaldi, Sabina, and Truong, Thérèse

Published
2023

34. Changes in Lifestyle and Risk of Colorectal Cancer in the European Prospective Investigation Into Cancer and Nutrition

Author

Epi Kanker Team C, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team B, Botteri, Edoardo, Peveri, Giulia, Berstad, Paula, Bagnardi, Vincenzo, Chen, Sairah L.F., Sandanger, Torkjel M., Hoff, Geir, Dahm, Christina C., Antoniussen, Christian S., Tjønneland, Anne, Eriksen, Anne Kirstine, Skeie, Guri, Perez-Cornago, Aurora, Huerta, José María, Jakszyn, Paula, Harlid, Sophia, Sundström, Björn, Barricarte, Aurelio, Monninkhof, Evelyn M., Derksen, Jeroen W.G., Schulze, Matthias B., Bueno-De-Mesquita, Bas, Sánchez, Maria Jose, Cross, Amanda J., Tsilidis, Konstantinos K., De Magistris, Maria Santucci, Kaaks, Rudolf, Katzke, Verena, Rothwell, Joseph A., Laouali, Nasser, Severi, Gianluca, Amiano, Pilar, Contiero, Paolo, Sacerdote, Carlotta, Goldberg, Marcel, Touvier, Mathilde, Freisling, Heinz, Viallon, Vivian, Weiderpass, Elisabete, Riboli, Elio, Gunter, Marc J., Jenab, Mazda, Ferrari, Pietro, Epi Kanker Team C, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team B, Botteri, Edoardo, Peveri, Giulia, Berstad, Paula, Bagnardi, Vincenzo, Chen, Sairah L.F., Sandanger, Torkjel M., Hoff, Geir, Dahm, Christina C., Antoniussen, Christian S., Tjønneland, Anne, Eriksen, Anne Kirstine, Skeie, Guri, Perez-Cornago, Aurora, Huerta, José María, Jakszyn, Paula, Harlid, Sophia, Sundström, Björn, Barricarte, Aurelio, Monninkhof, Evelyn M., Derksen, Jeroen W.G., Schulze, Matthias B., Bueno-De-Mesquita, Bas, Sánchez, Maria Jose, Cross, Amanda J., Tsilidis, Konstantinos K., De Magistris, Maria Santucci, Kaaks, Rudolf, Katzke, Verena, Rothwell, Joseph A., Laouali, Nasser, Severi, Gianluca, Amiano, Pilar, Contiero, Paolo, Sacerdote, Carlotta, Goldberg, Marcel, Touvier, Mathilde, Freisling, Heinz, Viallon, Vivian, Weiderpass, Elisabete, Riboli, Elio, Gunter, Marc J., Jenab, Mazda, and Ferrari, Pietro

Published
2023

35. Diet Quality, Microbial Lignan Metabolites, and Cardiometabolic Health among US Adults

Author

Koemel, Nicholas A., primary, Senior, Alistair M., additional, Benmarhnia, Tarik, additional, Holmes, Andrew, additional, Okada, Mirei, additional, Oulhote, Youssef, additional, Parker, Helen M., additional, Shah, Sanam, additional, Simpson, Stephen J., additional, Raubenheimer, David, additional, Gill, Timothy P., additional, Laouali, Nasser, additional, and Skilton, Michael R., additional

Published
2023
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39. Pre‐diagnostic Serum Glyceraldehyde‐Derived Advanced Glycation End Products and Mortality Among Colorectal Cancer Patients

Author

Mao, Ziling, primary, Baker, Jacqueline Roshelli, additional, Takeuchi, Masayoshi, additional, Hyogo, Hideyuki, additional, Tjønneland, Anne, additional, Eriksen, Anne Kirstine, additional, Severi, Gianluca, additional, Rothwell, Joseph, additional, Laouali, Nasser, additional, Katzke, Verena, additional, Kaaks, Rudolf, additional, Schulze, Matthias B., additional, Palli, Domenico, additional, Sieri, Sabina, additional, de Magistris, Maria Santucci, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Derksen, Jeroen W.G., additional, Gram, Inger T., additional, Skeie, Guri, additional, Sandanger, Torkjel M., additional, Quirós, Jose Ramón, additional, Crous‐Bou, Marta, additional, Sánchez, Maria‐Jose, additional, Amiano, Pilar, additional, Colorado‐Yohar, Sandra M., additional, Guevara, Marcela, additional, Harlid, Sophia, additional, Johansson, Ingegerd, additional, Perez‐Cornago, Aurora, additional, Freisling, Heinz, additional, Gunter, Marc, additional, Weiderpass, Elisabete, additional, Heath, Alicia K., additional, Aglago, Elom, additional, Jenab, Mazda, additional, and Fedirko, Veronika, additional

Published
2023
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41. The association between circulating 25-hydroxyvitamin D metabolites and type 2 diabetes in European populations: A meta-analysis and Mendelian randomisation analysis

Author

Zheng, Ju-Sheng, Luan, Jian'an, Sofianopoulou, Eleni, Sharp, Stephen J., Day, Felix R., Imamura, Fumiaki, Gundersen, Thomas E., Lotta, Luca A., Sluijs, Ivonne, Stewart, Isobel D., Shah, Rupal L., van der Schouw, Yvonne T., Wheeler, Eleanor, Ardanaz, Eva, Boeing, Heiner, Dorronsoro, Miren, Dahm, Christina C., Dimou, Niki, El-Fatouhi, Douae, Franks, Paul W., Fagherazzi, Guy, Grioni, Sara, Huerta, José María, Heath, Alicia K., Hansen, Louise, Jenab, Mazda, Jakszyn, Paula, Kaaks, Rudolf, Kühn, Tilman, Khaw, Kay-Tee, Laouali, Nasser, Masala, Giovanna, Nilsson, Peter M., Overvad, Kim, Olsen, Anja, Panico, Salvatore, Quirós, J. Ramón, Rolandsson, Olov, Rodríguez-Barranco, Miguel, Sacerdote, Carlotta, Spijkerman, Annemieke M. W., Tong, Tammy Y. N., Tumino, Rosario, Tsilidis, Konstantinos K., Danesh, John, Riboli, Elio, Butterworth, Adam S., Langenberg, Claudia, Forouhi, Nita G., and Wareham, Nicholas J.

Subjects
Vitamin D deficiency -- Complications and side effects -- Physiological aspects -- Genetic aspects, Type 2 diabetes -- Risk factors -- Development and progression -- Genetic aspects, Biological sciences
Abstract

Background Prior research suggested a differential association of 25-hydroxyvitamin D (25(OH)D) metabolites with type 2 diabetes (T2D), with total 25(OH)D and 25(OH)D.sub.3 inversely associated with T2D, but the epimeric form (C3-epi-25(OH)D.sub.3) positively associated with T2D. Whether or not these observational associations are causal remains uncertain. We aimed to examine the potential causality of these associations using Mendelian randomisation (MR) analysis. Methods and findings We performed a meta-analysis of genome-wide association studies for total 25(OH)D (N = 120,618), 25(OH)D.sub.3 (N = 40,562), and C3-epi-25(OH)D.sub.3 (N = 40,562) in participants of European descent (European Prospective Investigation into Cancer and Nutrition [EPIC]-InterAct study, EPIC-Norfolk study, EPIC-CVD study, Ely study, and the SUNLIGHT consortium). We identified genetic variants for MR analysis to investigate the causal association of the 25(OH)D metabolites with T2D (including 80,983 T2D cases and 842,909 non-cases). We also estimated the observational association of 25(OH)D metabolites with T2D by performing random effects meta-analysis of results from previous studies and results from the EPIC-InterAct study. We identified 10 genetic loci associated with total 25(OH)D, 7 loci associated with 25(OH)D.sub.3 and 3 loci associated with C3-epi-25(OH)D.sub.3 . Based on the meta-analysis of observational studies, each 1-standard deviation (SD) higher level of 25(OH)D was associated with a 20% lower risk of T2D (relative risk [RR]: 0.80; 95% CI 0.77, 0.84; p < 0.001), but a genetically predicted 1-SD increase in 25(OH)D was not significantly associated with T2D (odds ratio [OR]: 0.96; 95% CI 0.89, 1.03; p = 0.23); this result was consistent across sensitivity analyses. In EPIC-InterAct, 25(OH)D.sub.3 (per 1-SD) was associated with a lower risk of T2D (RR: 0.81; 95% CI 0.77, 0.86; p < 0.001), while C3-epi-25(OH)D.sub.3 (above versus below lower limit of quantification) was positively associated with T2D (RR: 1.12; 95% CI 1.03, 1.22; p = 0.006), but neither 25(OH)D.sub.3 (OR: 0.97; 95% CI 0.93, 1.01; p = 0.14) nor C3-epi-25(OH)D.sub.3 (OR: 0.98; 95% CI 0.93, 1.04; p = 0.53) was causally associated with T2D risk in the MR analysis. Main limitations include the lack of a non-linear MR analysis and of the generalisability of the current findings from European populations to other populations of different ethnicities. Conclusions Our study found discordant associations of biochemically measured and genetically predicted differences in blood 25(OH)D with T2D risk. The findings based on MR analysis in a large sample of European ancestry do not support a causal association of total 25(OH)D or 25(OH)D metabolites with T2D and argue against the use of vitamin D supplementation for the prevention of T2D., Author(s): Ju-Sheng Zheng 1,2,*, Jian'an Luan 1, Eleni Sofianopoulou 3,4, Stephen J. Sharp 1, Felix R. Day 1, Fumiaki Imamura 1, Thomas E. Gundersen 5, Luca A. Lotta 1, Ivonne [...]

Published
2020
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42. Plant-Based Diets and the Incidence of Asthma Symptoms among Elderly Women, and the Mediating Role of Body Mass Index

Author

Ait-hadad, Wassila, primary, Bédard, Annabelle, additional, Delvert, Rosalie, additional, Orsi, Laurent, additional, Chanoine, Sébastien, additional, Dumas, Orianne, additional, Laouali, Nasser, additional, Le Moual, Nicole, additional, Leynaert, Bénédicte, additional, Siroux, Valérie, additional, Boutron-Ruault, Marie-Christine, additional, and Varraso, Raphaëlle, additional

Published
2022
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44. Changes in Lifestyle and Risk of Colorectal Cancer in the European Prospective Investigation Into Cancer and Nutrition

Author

Botteri, Edoardo, primary, Peveri, Giulia, additional, Berstad, Paula, additional, Bagnardi, Vincenzo, additional, Chen, Sairah L.F., additional, Sandanger, Torkjel M., additional, Hoff, Geir, additional, Dahm, Christina C., additional, Antoniussen, Christian S., additional, Tjønneland, Anne, additional, Eriksen, Anne Kirstine, additional, Skeie, Guri, additional, Perez-Cornago, Aurora, additional, Huerta, José María, additional, Jakszyn, Paula, additional, Harlid, Sophia, additional, Sundström, Björn, additional, Barricarte, Aurelio, additional, Monninkhof, Evelyn M., additional, Derksen, Jeroen W.G., additional, Schulze, Matthias B., additional, Bueno-de-Mesquita, Bas, additional, Sánchez, Maria-Jose, additional, Cross, Amanda J., additional, Tsilidis, Konstantinos K., additional, De Magistris, Maria Santucci, additional, Kaaks, Rudolf, additional, Katzke, Verena, additional, Rothwell, Joseph A., additional, Laouali, Nasser, additional, Severi, Gianluca, additional, Amiano, Pilar, additional, Contiero, Paolo, additional, Sacerdote, Carlotta, additional, Goldberg, Marcel, additional, Touvier, Mathilde, additional, Freisling, Heinz, additional, Viallon, Vivian, additional, Weiderpass, Elisabete, additional, Riboli, Elio, additional, Gunter, Marc J., additional, Jenab, Mazda, additional, and Ferrari, Pietro, additional

Published
2022
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47. Adherence to mediterranean diet and the risk of differentiated thyroid cancer in a European cohort: The EPIC study

Author

Llaha, Fjorida, primary, Cayssials, Valerie, additional, Farràs, Marta, additional, Agudo, Antonio, additional, Sandström, Maria, additional, Eriksen, Anne Kirstine, additional, Tjønneland, Anne, additional, Boutron-Ruault, Marie-Christine, additional, Laouali, Nasser, additional, Truong, Thérèse, additional, Le Cornet, Charlotte, additional, Katzke, Verena, additional, Schulze, Matthias, additional, Palli, Domenico, additional, Krogh, Vittorio, additional, Signoriello, Simona, additional, Tumino, Rosario, additional, Ricceri, Fulvio, additional, Skeie, Guri, additional, Jensen, Torill Miriam Enget, additional, Chen, Sairah Lai Fa, additional, Lasheras, Cristina, additional, Rodriguez-Barranco, Miguel, additional, Amiano, Pilar, additional, Huerta, José María, additional, Guevara, Marcela, additional, Almquist, Martin, additional, Nilson, Lena Maria, additional, Hennings, Joakim, additional, Papier, Keren, additional, Heath, Alicia, additional, Weiderpass, Elisabete, additional, Rinaldi, Sabina, additional, and Zamora-Ros, Raul, additional

Published
2022
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50. Relative to processed red meat, alternative protein sources are associated with a lower risk of hypertension and diabetes in a prospective cohort of French women.

Author

Thao, Uyen, Lajous, Martin, Laouali, Nasser, Severi, Gianluca, Boutron-Ruault, Marie-Christine, and MacDonald, Conor James

Subjects
HYPERTENSION risk factors, DIABETES risk factors, EGGS, MEAT, CONFIDENCE intervals, FOOD security, SELF-evaluation, FOOD animals, PACKAGED foods, COMPARATIVE studies, QUESTIONNAIRES, DESCRIPTIVE statistics, DIETARY proteins, WOMEN'S health, LONGITUDINAL method, PROPORTIONAL hazards models
Abstract

Many dietary guidelines recommend restricting the consumption of processed red meat (PRM) in favour of healthier foods such as fish, to reduce the risk of chronic conditions such as hypertension and diabetes. The objective of this study was to estimate the potential effect of replacing PRM for fatty fish, lean fish, red meat, eggs, pulses, or vegetables, on the risk of incident hypertension and diabetes. This was a prospective study of women in the E3N cohort study. Cases of diabetes and hypertension were based on self-report, specific questionnaires, and drug reimbursements. In the main analysis, information on regular dietary intake was assessed with a single food history questionaire, and food substitutions were modelled using cox proportional hazard models. 95 % confidence intervals were generated via bootstrapping. 71 081 women free of diabetes and 45 771 women free of hypertension were followed for an average of 18·7 and 18·3 years, respectively. 2681 incident cases of diabetes and 12 327 incident cases of hypertension were identified. Relative to PRM, fatty fish was associated with a 15 % lower risk of diabetes (HR = 0·85, 95 CI (0·73, 0·97)) and hypertension (HR = 0 85 (0·79, 0·91)). Between 3 and 10 % lower risk of hypertension or diabetes was also observed when comparing PRM with vegetables, unprocessed red meat or pulses. Relative to PRM, alternative protein sources such as fatty fish, unprocessed red meat, vegetables or pulses was associated with a lower risk of hypertension and diabetes. [ABSTRACT FROM AUTHOR]

Published
2023
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