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Your search keyword '"Laoaroon, Napat"' showing total 14 results
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14 results on '"Laoaroon, Napat"'

5. A 3-year-old child with multiple superficial erosions and yellowish crusts on the scalp and seborrheic areas

Author

Techasatian, Leelawadee, primary, Laoaroon, Napat, additional, Suwannaying, Kunanya, additional, Komwilaisak, Patcharee, additional, Uppala, Rattapon, additional, Sitthikarnkha, Panthila, additional, Saengnipanthkul, Suchaorn, additional, Ungarreevittaya, Piti, additional, Chaowattanapanit, Suteeraporn, additional, and Choonhakarn, Charoen, additional

Published
2024
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9. Treatment outcomes of high-dose chemotherapy plus stem cell rescue in high-risk neuroblastoma patients in Thailand

Author

Suwannaying, Kunanya, primary, Techavichit, Piti, additional, Komvilaisak, Patcharee, additional, Laoaroon, Napat, additional, Narkbunnam, Nattee, additional, Sanpakit, Kleebsabai, additional, Chiengthong, Kanhatai, additional, Chotsampancharoen, Thirachit, additional, Sathitsamitphong, Lalita, additional, Santong, Chalongpon, additional, Seksarn, Panya, additional, Hongeng, Suradej, additional, and Wiangnon, Surapon, additional

Published
2022
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11. Meta-Analysis of NUDT15 Genetic Polymorphism on Thiopurine-Induced Myelosuppression in Asian Populations

Author

Khaeso, Kanyarat, primary, Udayachalerm, Sariya, additional, Komvilaisak, Patcharee, additional, Chainansamit, Su-on, additional, Suwannaying, Kunanya, additional, Laoaroon, Napat, additional, Kuwatjanakul, Pitchayanan, additional, Nakkam, Nontaya, additional, Sukasem, Chonlaphat, additional, Puangpetch, Apichaya, additional, Tassaneeyakul, Wichittra, additional, and Chaiyakunapruk, Nathorn, additional

Published
2021
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12. Hand Hygiene Habits and Prevalence of Hand Eczema During the COVID-19 Pandemic

Author

Techasatian, Leelawadee, primary, Thaowandee, Wilairat, additional, Chaiyarit, Jitjira, additional, Uppala, Rattapon, additional, Sitthikarnkha, Phanthila, additional, Paibool, Watuhatai, additional, Charoenwat, Busara, additional, Wongmast, Piyathida, additional, Laoaroon, Napat, additional, Suphakunpinyo, Chanyut, additional, Kiatchoosakun, Pakaphan, additional, and Kosalaraksa, Pope, additional

Published
2021
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13. Impact of HbE mutation on the clinical severity of HbH disease: A multicentre study from Thailand.

Author

Songdej, Duantida, Teawtrakul, Nattiya, Laoaroon, Napat, Komvilaisak, Patcharee, Sripornsawan, Pornpun, Surapolchai, Pacharapan, Hantaweepant, Chattree, Tantiworawit, Adisak, Hantrakool, Sasinee, Lauhasurayotin, Supanun, Torcharus, Kitti, Sutcharitchan, Pranee, Uaprasert, Noppacharn, Panrong, Krissana, Silpsamrit, Panachai, Meekaewkunchorn, Arunotai, Charoenkwan, Pimlak, and Pongtanakul, Bunchoo

Subjects
*DISEASE management, *PHENOTYPES, *HEMOGLOBINS, *SPLENECTOMY
Abstract

Summary Haemoglobin (Hb) H disease and HbH disease with co‐inherited HbE mutation are the most prevalent forms of α‐thalassaemia in Southeast Asia. Data were limited when comparing clinical phenotypes between these two patient groups. We conducted a Thai multicentre study and enrolled 588 patients [median (IQR) age 13.0 (6.7–20.3) years], including those with deletional HbH disease with (n = 47) and without (n = 187) co‐inherited HbE mutation and non‐deletional HbH disease with (n = 101) and without (n = 253) co‐inherited HbE mutation. Patients with HbH disease with co‐inherited HbE mutation suffered more severe manifestations than those without. This observation was more pronounced in patients with non‐deletional HbH disease. A greater proportion of patients with non‐deletional HbH disease with co‐inherited HbE mutation (43.6%) eventually required regular transfusions compared to those without (30.4%, p = 0.019). Among those with non‐deletional HbH disease who did not require regular transfusions, Hb levels were lower in patients with co‐inherited HbE mutation [8.1 (7.2–8.6) vs. 8.8 (8.2–9.5) g/dL, p < 0.001]. Among patients requiring regular transfusions who underwent splenectomy, 11/12 patients with non‐deletional HbH disease stopped transfusion compared with 1/3 in non‐deletional HbH disease with co‐inherited HbE mutation group (p = 0.024). These findings provide insights for the clinical monitoring and management of HbH disease in the region. [ABSTRACT FROM AUTHOR]

Published
2024
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14. NUDT15is a key genetic factor for prediction of hematotoxicity in pediatric patients who received a standard low dosage regimen of 6-mercaptopurine

Author

Khaeso, Kanyarat, Komwilaisak, Patcharee, Chainansamit, Su-on, Nakkam, Nontaya, Suwannaying, Kunanya, Kuwatjanakul, Pitchayanan, Hikino, Keiko, Dornsena, Areerat, Kanjanawart, Sirimas, Laoaroon, Napat, Vannaprasaht, Suda, Taketani, Takeshi, and Tassaneeyakul, Wichittra

Abstract

6-Mercaptopurine (6-MP) is commonly used for treatment of acute lymphoblastic leukemia (ALL). The incidence of hematotoxicity caused by this drug is quite high in Asians even using a standard low dosage regimen. The present study was aimed to elucidate the impact of thiopurine S-methyltransferase (TPMT), a nucleoside diphosphate-linked moiety X-type motif 15 (NUDT15), inosine triphosphatase (ITPA) and ATP Binding Cassette Subfamily C Member 4 (ABCC4) polymorphisms on hematotoxicity in pediatric patients who received a standard low starting dose of 6-MP. One hundred and sixty-nine pediatric patients were enrolled and their genotypes were determined. Patients who carried NUDT15*3and NUDT15*2genotypes were at a 10–15 fold higher risk of severe neutropenia than those of the wild-type during the early months of the maintenance phase. Risk of neutropenia was not significantly increased in patients with other NUDT15variants as well as in patients with TPMT, ITPAor ABCC4variants. These results suggest that NUDT15polymorphisms particularly, NUDT15*3and NUDT15*2,play major roles in 6-MP-induced severe hematotoxicity even when using a standard low dosage of 6-MP and genotyping of these variants is necessary in order to obtain precise tolerance doses and avoid severe hematotoxicity in pediatric patients.

Published
2021
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