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12 results on '"Lanzaro, Francesca"'

3. Transient erythroblastopenia of childhood after Covid-19 infection: a case report

Author

Rivetti, Giulio, primary, Abbate, Fabio Giovanni, additional, Longobardi, Marialaura, additional, Marrapodi, Maria Maddalena, additional, Lanzaro, Francesca, additional, Martino, Martina Di, additional, Vallefuoco, Fara, additional, D’Angelo, Velia, additional, Casale, Maddalena, additional, Tartaglione, Immacolata, additional, Perrotta, Silverio, additional, and Roberti, Domenico, additional

Published
2024
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4. Childhood Multiple Endocrine Neoplasia (MEN) Syndromes: Genetics, Clinical Heterogeneity and Modifying Genes.

Author

Lanzaro, Francesca, De Biasio, Delia, Cesaro, Francesco Giustino, Stampone, Emanuela, Tartaglione, Immacolata, Casale, Maddalena, Bencivenga, Debora, Marzuillo, Pierluigi, and Roberti, Domenico

Subjects
*GENETIC variation, *SYMPTOMS, *PATIENTS' families, *AGE of onset, *CANCER patients
Abstract

Multiple endocrine neoplasia (MEN) syndromes are part of a spectrum of clinically well-defined tumor syndromes ultimately characterized by histologically similar tumors arising in patients and families with mutations in one of the following four genes: MEN1, RET, CDKN1B, and MAX. The high level of genetic and phenotypic heterogeneity has been linked to phenocopies and modifying genes, as well as unknown mechanisms that might be investigated in the future based on preclinical and translational considerations. MEN1, also known as Wermer's syndrome (OMIM *131100), is an autosomal dominant syndrome codifying for the most frequent MEN syndrome showing high penetrance due to mutations in the MEN1 gene; nevertheless, clinical manifestations vary among patients in terms of tumor localization, age of onset, and clinical aggressiveness/severity, even within the same families. This has been linked to the effect of modifying genes, as described in the review. MEN 2-2b-4 and 5 also show remarkable clinical heterogeneity. The traditional view of genetically predisposing monogenic or multifactorial disorders is no longer valid, and mandates a change in scientific focus. Phenotypes are indeed rarely consistent across genetic backgrounds and environments. In the future, understanding factors and genetic variants that control cellular functions and the expression of disease genes should provide insights into fundamental disease processes, providing implications for counseling and therapeutic and prophylactic possibilities. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Development of a Potency Assay for Nous-209, a Multivalent Neoantigens-Based Genetic Cancer Vaccine

Author

Bartolomeo, Rosa, primary, Troise, Fulvia, additional, Allocca, Simona, additional, Sdruscia, Giulia, additional, Vitale, Rosa, additional, Bignone, Veronica, additional, Petrone, Anna Maria, additional, Romano, Giuseppina, additional, D’Alise, Anna Morena, additional, Ruzza, Valentino, additional, Garzia, Irene, additional, Leoni, Guido, additional, Merone, Rossella, additional, Lanzaro, Francesca, additional, Colloca, Stefano, additional, Siani, Loredana, additional, Scarselli, Elisa, additional, and Cotugno, Gabriella, additional

Published
2024
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7. Updated Analysis on the Outcomes of Children with Acute Leukemia (AL) Receiving an Alpha/Beta T and B-Cell Depleted HLA-Haploidentical Hematopoietic Stem Cell Transplantation (TBdepl-haploHSCT)

Author

Merli, Pietro, primary, Algeri, Mattia, additional, Galaverna, Federica, additional, Quagliarella, Francesco, additional, Bertaina, Valentina, additional, Girolami, Elia, additional, Meschini, Antonella, additional, Del Principe, Giovanna, additional, Biagini, Simone, additional, Sborgia, Raffaella, additional, Lucarelli, Barbarella, additional, Pagliara, Daria, additional, Catanoso, Marialuigia, additional, Rosignoli, Chiara, additional, Cossutta, Matilde, additional, Lanzaro, Francesca, additional, Canino, Costanza, additional, Cefalo, Maria Giuseppina, additional, Strocchio, Luisa, additional, Boccieri, Emilia, additional, Becilli, Marco, additional, Carta, Roberto, additional, Del Bufalo, Francesca, additional, Li Pira, Giuseppina, additional, and Locatelli, Franco, additional

Published
2022
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10. Correction: A next generation vaccine against human rabies based on a single dose of a chimpanzee adenovirus vector serotype C

Author

Napolitano, Federico, primary, Merone, Rossella, additional, Abbate, Adele, additional, Ammendola, Virginia, additional, Horncastle, Emma, additional, Lanzaro, Francesca, additional, Esposito, Marialuisa, additional, Contino, Alessandra Maria, additional, Sbrocchi, Roberta, additional, Sommella, Andrea, additional, Duncan, Joshua D., additional, Hinds, Joseph, additional, Urbanowicz, Richard A., additional, Lahm, Armin, additional, Colloca, Stefano, additional, Folgori, Antonella, additional, Ball, Jonathan K., additional, Nicosia, Alfredo, additional, Wizel, Benjamin, additional, Capone, Stefania, additional, and Vitelli, Alessandra, additional

Published
2021
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11. A next generation vaccine against human rabies based on a single dose of a chimpanzee adenovirus vector serotype C

Author

Napolitano, Federico, primary, Merone, Rossella, additional, Abbate, Adele, additional, Ammendola, Virginia, additional, Horncastle, Emma, additional, Lanzaro, Francesca, additional, Esposito, Marialuisa, additional, Contino, Alessandra Maria, additional, Sbrocchi, Roberta, additional, Sommella, Andrea, additional, Duncan, Joshua D., additional, Hinds, Jospeh, additional, Urbanowicz, Richard A., additional, Lahm, Armin, additional, Colloca, Stefano, additional, Folgori, Antonella, additional, Ball, Jonathan K., additional, Nicosia, Alfredo, additional, Wizel, Benjamin, additional, Capone, Stefania, additional, and Vitelli, Alessandra, additional

Published
2020
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12. Metabolic-associated fatty liver disease from childhood to adulthood: State of art and future directions

Author

Francesca Lanzaro, Stefano Guarino, Elisabetta D'Addio, Alessandra Salvatori, Josè Alberto D'Anna, Pierluigi Marzuillo, Emanuele Miraglia del Giudice, Anna Di Sessa, Lanzaro, Francesca, Guarino, Stefano, D'Addio, Elisabetta, Salvatori, Alessandra, D'Anna, Josè Alberto, Marzuillo, Pierluigi, Miraglia Del Giudice, Emanuele, and Di Sessa, Anna

Subjects
Adult, Risk, dysfunction, Fatty, Liver, Hepatology, Metabolic, Cardiovascular, Children, Pathophysiology
Abstract

In 2020, an international group of experts proposed to replace the term of nonalcoholic fatty liver disease with metabolic-associated fatty liver disease (MAFLD). This recent proposal reflects the close association of fatty liver with metabolic derangements, as demonstrated by previous robust data. Several factors [including genetics, inflammation, metabolic abnormalities, insulin resistance (IR), obesity, prenatal determinants, and gut-liver axis] have been found to be involved in MAFLD pathophysiology, but this tangled puzzle remains to be clearly understood. In particular, IR has been recognized as a key player in metabolic impairments development in children with fatty liver. On this ground, MAFLD definition focuses on the pathophysiological basis of the disease, by emphasizing the crucial role of metabolic impairments in this condition. Although primarily developed for adults, MAFLD diagnostic criteria have been recently updated with an age-appropriate definition for sex and age percentiles, because of the increasing attention to cardiometabolic risk in childhood. To date, accumulating evidence is available on the feasibility of MAFLD definition in clinical practice, but some data are still conflicting in highly selected populations. Considering the growing prevalence worldwide of fatty liver and its close relationship with metabolic dysfunction both in children and adults with subsequent increased cardiovascular risk, early strategies for MAFLD identification, treatment and prevention are needed. Novel therapeutic insights for MAFLD based on promising innovative biological techniques are also emerging. We aimed to summarize the most recent evidence in this intriguing research area both in children and adults.

Published
2022
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