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1. Functional coupling between ryanodine receptors and L-type calcium channels in neurons

Author

Chavis, P., Fagni, L., Lansman, J.B., and Bockaert, J.

Subjects
Calcium channels -- Physiological aspects, Neurons -- Analysis, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The stimulation of the type-1 metabotropic glutamate receptor (mGluR1) induces a tight functional coupling between ryanodine receptors and L-type calcium channels in neurons. The stimulation of mGluR1 facilitates L-type calcium channel activity. The stimulation of channel activity is independent of inositol 1,4,5-trisphosphate and typical protein kinases, and is mimicked by caffeine. Ryanodine inhibits both the mGluR1 and caffeine-induced increase in L-type calcium channels in neurons.

Published
1996

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