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3. Multicenter Canadian case series of pediatric patients less than 12 years of age with moderate‐to‐severe atopic dermatitis treated with dupilumab

Author

Martinez‐Cabriales, Sylvia, primary, Marcoux, Danielle, additional, Liy‐Wong, Carmen, additional, Prajapati, Vimal H., additional, Sibbald, Cathryn, additional, Cunningham, Natalie, additional, Lansang, Perla, additional, Tonkin, Rochelle, additional, Joseph, Marissa, additional, Wong, Lauren, additional, Spring, Shanna, additional, Gavigan, Genevieve, additional, and Ramien, Michele, additional

Published
2023
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4. Treat-to-target in the management of moderate-to-severe atopic dermatitis in adults: A Canadian perspective

Author

Yeung, Jensen, primary, Gooderham, Melinda J., additional, Hong, H. Chih-Ho, additional, Lynde, Charles, additional, Prajapati, Vimal H., additional, Lansang, Perla, additional, Turchin, Irina, additional, Wiseman, Marni, additional, Jack, Carolyn, additional, Ramien, Michele, additional, Purdy, Kerri, additional, and Grewal, Parbeer, additional

Published
2023
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5. Multicenter Canadian case series of pediatric patients less than 12 years of age with moderate‐to‐severe atopic dermatitis treated with dupilumab.

Author

Martinez‐Cabriales, Sylvia, Marcoux, Danielle, Liy‐Wong, Carmen, Prajapati, Vimal H., Sibbald, Cathryn, Cunningham, Natalie, Lansang, Perla, Tonkin, Rochelle, Joseph, Marissa, Wong, Lauren, Spring, Shanna, Gavigan, Genevieve, and Ramien, Michele

Subjects
CHILD patients, DUPILUMAB, ATOPIC dermatitis, ECZEMA, PATIENT safety, QUALITY of life
Abstract

Background: Dupilumab is approved for moderate‐severe atopic dermatitis (AD) in patients aged ≥6 months by the US Food and Drug Administration and Health Canada; however, there are little real‐world data because providers have limited practical experience with this recently approved therapy. Objectives: To describe the real‐world effectiveness and safety in patients aged <12 years with moderate‐severe AD currently receiving or previously having received dupilumab. Methods: A multicenter retrospective study was conducted at six Canadian sites. Cases were divided into Group 1 ≤2 years old, Group 2 >2 to <6 years old, and Group 3 ≥6 to <12 years old. Medical history and details of dupilumab treatment were collected. The primary outcome was to measure the improvement in eczema area and severity index. Secondary outcomes examined included the children's dermatology life quality index/infant's dermatitis quality of life, peak pruritus numerical rating scale, and delay to dupilumab access for patients who were considered off‐label for dupilumab due to their age. Results: Sixty three pediatric patients (37 males) with moderate‐to‐severe AD were included; the mean age was 6.4 years old (range: 2–11) when dupilumab treatment was started. Overall, 75% (36/48) achieved EASI‐75% and 71% (34/48) achieved EASI‐90. EASI‐75 and EASI‐90 were achieved in 90% (17/19) and 73% (12/19) in patients <6 years old, and 76% (22/29) and 59% (17/29) in patients >6 years old, respectively. No serious adverse events were reported. Conclusions: Dupilumab is safe and effective for patients under the age of 12. However, even for experienced providers, access to the medication was challenging. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Figure S1 - Supplemental material for Reported Pregnancy Outcomes in Women With Severe Atopic Dermatitis Treated With Dupilumab: A Systematic Review

Author

Akuffo-Addo, Edgar, Nicholas, Mathew N., and Lansang, Perla

Subjects
Medicine
Abstract

Supplemental material, Figure S1, for Reported Pregnancy Outcomes in Women With Severe Atopic Dermatitis Treated With Dupilumab: A Systematic Review by Edgar Akuffo-Addo, Mathew N. Nicholas and Perla Lansang in Journal of Cutaneous Medicine and Surgery

Published
2023
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13. Incidence and prognosis of COVID-19 in patients with atopic diseases on dupilumab: a multicentre retrospective cohort study

Author

Rankin, Brian D., primary, Georgakopoulos, Jorge-Ryan, additional, Sachdeva, Muskaan, additional, Mufti, Asfandyar, additional, Devani, Alim R., additional, Gooderham, Melinda J., additional, Hong, Chih-Ho, additional, Jain, Vipul, additional, Lansang, Perla, additional, Vender, Ronald, additional, Yeung, Jensen, additional, and Prajapati, Vimal H., additional

Published
2022
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16. Incidence of COVID-19 in Patients With Chronic Idiopathic Urticaria and Asthma on Omalizumab: A Multicentre Retrospective Cohort Study

Author

Abduelmula, Abrahim, primary, Georgakopoulos, Jorge R., additional, Mufti, Asfandyar, additional, Devani, Alim R., additional, Gooderham, Melinda J., additional, Hong, Chih-Ho, additional, Jain, Vipul, additional, Lansang, Perla, additional, Vender, Ronald, additional, Prajapati, Vimal H., additional, and Yeung, Jensen, additional

Published
2021
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19. Systematic Review on the Efficacy and Safety of Oral Janus Kinase Inhibitors for the Treatment of Atopic Dermatitis

Author

Le, Michelle, primary, Berman-Rosa, Melissa, additional, Ghazawi, Feras M., additional, Bourcier, Marc, additional, Fiorillo, Loretta, additional, Gooderham, Melinda, additional, Guenther, Lyn, additional, Hanna, Sameh, additional, Hong, H. Chih-Ho, additional, Landells, Ian, additional, Lansang, Perla, additional, Marcoux, Danielle, additional, Wiseman, Marni C., additional, Yeung, Jensen, additional, Lynde, Charles, additional, and Litvinov, Ivan V., additional

Published
2021
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21. Table S2 - Supplemental material for The Utility of IL-17 Inhibitors in Neutrophilic Dermatoses: A Systematic Review

Author

Elsawi, Rawaan, Brooks, Stephanie G., Georgakopolous, Jorge R., Lansang, Perla, Piguet, Vincent, and Croitoru, David

Subjects
Medicine
Abstract

Supplemental material, Table S2, for The Utility of IL-17 Inhibitors in Neutrophilic Dermatoses: A Systematic Review by Rawaan Elsawi, Stephanie G. Brooks, Jorge R. Georgakopolous, Perla Lansang, Vincent Piguet and David Croitoru in Journal of Cutaneous Medicine and Surgery

Published
2021
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22. Figure S1 - Supplemental material for The Utility of IL-17 Inhibitors in Neutrophilic Dermatoses: A Systematic Review

Author

Elsawi, Rawaan, Brooks, Stephanie G., Georgakopolous, Jorge R., Lansang, Perla, Piguet, Vincent, and Croitoru, David

Subjects
Medicine
Abstract

Supplemental material, Figure S1., for The Utility of IL-17 Inhibitors in Neutrophilic Dermatoses: A Systematic Review by Rawaan Elsawi, Stephanie G. Brooks, Jorge R. Georgakopolous, Perla Lansang, Vincent Piguet and David Croitoru in Journal of Cutaneous Medicine and Surgery

Published
2021
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28. Population pharmacokinetic and exposure–efficacy analysis of ixekizumab in paediatric patients with moderate‐to‐severe plaque psoriasis (IXORA‐PEDS).

Author

Jackson, Kimberley, Chua, Laiyi, Velez de Mendizabal, Nieves, Pitou, Celine, Rodriguez Capriles, Claudia, Paller, Amy S., Lansang, Perla, Seyger, Marieke M. B., and Papp, Kim

Subjects
CHILD patients, PSORIASIS, CLINICAL trials, PHARMACOKINETICS, MONOCLONAL antibodies
Abstract

Aims: Ixekizumab is a high‐affinity monoclonal antibody that selectively targets interleukin‐17A used in the treatment of adult and paediatric patients with moderate‐to‐severe psoriasis. This analysis evaluated the pharmacokinetics (PK) of ixekizumab and the exposure–efficacy relationship in paediatric patients aged 6 to <18 years with psoriasis. Methods: Population PK and exposure–efficacy models were developed. The models used data from paediatric patients with psoriasis participating in the Phase 3 IXORA‐PEDS trial in which patients were dosed according to weight categories. The exposure–efficacy model is a Psoriasis Area and Severity Index (PASI) time course model using data up to Week 12, a co‐primary efficacy endpoint. Results: A 2‐compartment population PK model describes the PK of ixekizumab in paediatric patients with the effect of body weight incorporated on clearance and volume terms using an allometric relationship. The weight category‐based dosing ensured that ixekizumab mean trough serum concentrations in paediatric patients with psoriasis (3.20–3.33 μg/mL) were within the range of concentrations observed in adult patients with psoriasis (mean [standard deviation]: 3.48 [2.16] μg/mL) administered an efficacious dosing regimen. The observed PASI response rates at Week 12 in paediatric patients (91.9/81.8/52.5% for PASI75/90/100) are well predicted by the final exposure–efficacy model and response rates are similar or higher than those achieved in adults (86.2/66.6/35.0% for PASI75/90/100). Conclusion: This analysis is the first to describe the PK and exposure–efficacy relationship of ixekizumab in paediatric patients with psoriasis. The analyses support the selection of the weight category‐based ixekizumab dosing regimens approved for use in paediatric patients with psoriasis. [ABSTRACT FROM AUTHOR]

Published
2022
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29. Supplementary Material 1 - Supplemental material for Management of Plaque Psoriasis With Biologic Therapies in Women of Child-Bearing Potential Consensus Paper

Author

Jensen Yeung, Gooderham, Melinda J., Parbeer Grewal, Chih-Ho Hong, Lansang, Perla, Papp, Kim A., Poulin, Yves, Turchin, Irina, and Vender, Ronald

Subjects
Medicine
Abstract

Supplemental material, Supplementary Material 1, for Management of Plaque Psoriasis With Biologic Therapies in Women of Child-Bearing Potential Consensus Paper by Jensen Yeung, Melinda J. Gooderham, Parbeer Grewal, Chih-ho Hong, Perla Lansang, Kim A. Papp, Yves Poulin, Irina Turchin and Ronald Vender in Journal of Cutaneous Medicine and Surgery

Published
2020
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30. Supplementary Material 1 - Supplemental material for Skin Damage Prevention Strategies During COVID-19: Assessing Their Effect on N95 Mask Seal Integrity

Author

Lansang, Perla, Orrell, Kelsey A., Tran, Jennifer, and Chen, Tiffany

Subjects
Medicine
Abstract

Supplemental material, Supplementary Material 1, for Skin Damage Prevention Strategies During COVID-19: Assessing Their Effect on N95 Mask Seal Integrity by Perla Lansang, Kelsey A. Orrell, Jennifer Tran and Tiffany Chen in Journal of Cutaneous Medicine and Surgery

Published
2020
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31. Supplementary Material 2 - Supplemental material for Management of Plaque Psoriasis With Biologic Therapies in Women of Child-Bearing Potential Consensus Paper

Author

Jensen Yeung, Gooderham, Melinda J., Parbeer Grewal, Chih-Ho Hong, Lansang, Perla, Papp, Kim A., Poulin, Yves, Turchin, Irina, and Vender, Ronald

Subjects
Medicine
Abstract

Supplemental material, Supplementary Material 2, for Management of Plaque Psoriasis With Biologic Therapies in Women of Child-Bearing Potential Consensus Paper by Jensen Yeung, Melinda J. Gooderham, Parbeer Grewal, Chih-ho Hong, Perla Lansang, Kim A. Papp, Yves Poulin, Irina Turchin and Ronald Vender in Journal of Cutaneous Medicine and Surgery

Published
2020
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33. Approach to the Assessment and Management of Pediatric Patients With Atopic Dermatitis: A Consensus Document. Section IV: Consensus Statements on the Assessment and Management of Pediatric Atopic Dermatitis

Author

Lansang, Perla, primary, Lara-Corrales, Irene, additional, Bergman, James N., additional, Hong, Chih-ho, additional, Joseph, Marissa, additional, Kim, Vy H.D., additional, Lam, Joseph M., additional, Landells, Ian, additional, Marcoux, Danielle, additional, Prajapati, Vimal H., additional, Ramien, Michele L., additional, and Spring, Shanna, additional

Published
2019
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38. 1329_Section_0_Supplementary_Appendix_A_23Oct18 – Supplemental material for Approach to the Assessment and Management of Adult Patients With Atopic Dermatitis: A Consensus Document

Author

Gooderham, Melinda J., Chih-Ho Hong, Albrecht, Lorne, Bissonnette, Robert, Gurbir Dhadwal, Gniadecki, Robert, Parbeer Grewal, Kirchhof, Mark G., Landells, Ian, Lansang, Perla, Lynde, Chuck W., Papp, Kim A., Poulin, Yves, Sussman, Gordon, Turchin, Irina, Wiseman, Marni, and Jensen Yeung

Subjects
Medicine
Abstract

Supplemental material, 1329_Section_0_Supplementary_Appendix_A_23Oct18 for Approach to the Assessment and Management of Adult Patients With Atopic Dermatitis: A Consensus Document by Melinda J. Gooderham, Chih-ho Hong, Lorne Albrecht, Robert Bissonnette, Gurbir Dhadwal, Robert Gniadecki, Parbeer Grewal, Mark G. Kirchhof, Ian Landells, Perla Lansang, Chuck W. Lynde, Kim A. Papp, Yves Poulin, Gordon Sussman, Irina Turchin, Marni Wiseman and Jensen Yeung in Journal of Cutaneous Medicine and Surgery

Published
2018
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39. Hong_article_section_V__803625 – Supplemental material for Approach to the Assessment and Management of Adult Patients With Atopic Dermatitis: A Consensus Document. Section V: Consensus Statements on the Assessment and Management of Adult Patients With Moderate-to-Severe Atopic Dermatitis

Author

Chih-Ho Hong, Gooderham, Melinda J., Albrecht, Lorne, Bissonnette, Robert, Gurbir Dhadwal, Gniadecki, Robert, Parbeer Grewal, Kirchhof, Mark G., Landells, Ian, Lansang, Perla, Lynde, Chuck W., Papp, Kim A., Poulin, Yves, Sussman, Gordon, Turchin, Irina, Wiseman, Marni, and Jensen Yeung

Subjects
Medicine
Abstract

Supplemental material, Hong_article_section_V__803625 for Approach to the Assessment and Management of Adult Patients With Atopic Dermatitis: A Consensus Document. Section V: Consensus Statements on the Assessment and Management of Adult Patients With Moderate-to-Severe Atopic Dermatitis by Chih-ho Hong, Melinda J. Gooderham, Lorne Albrecht, Robert Bissonnette, Gurbir Dhadwal, Robert Gniadecki, Parbeer Grewal, Mark G. Kirchhof, Ian Landells, Perla Lansang, Chuck W. Lynde, Kim A. Papp, Yves Poulin, Gordon Sussman, Irina Turchin, Marni Wiseman and Jensen Yeung in Journal of Cutaneous Medicine and Surgery

Published
2018
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40. JCMS_Gooderham_803627 – Supplemental material for Approach to the Assessment and Management of Adult Patients With Atopic Dermatitis: A Consensus Document

Author

Gooderham, Melinda J., Chih-Ho Hong, Albrecht, Lorne, Bissonnette, Robert, Gurbir Dhadwal, Gniadecki, Robert, Parbeer Grewal, Kirchhof, Mark G., Landells, Ian, Lansang, Perla, Lynde, Chuck W., Papp, Kim A., Poulin, Yves, Sussman, Gordon, Turchin, Irina, Wiseman, Marni, and Jensen Yeung

Subjects
Medicine
Abstract

Supplemental material, JCMS_Gooderham_803627 for Approach to the Assessment and Management of Adult Patients With Atopic Dermatitis: A Consensus Document by Melinda J. Gooderham, Chih-ho Hong, Lorne Albrecht, Robert Bissonnette, Gurbir Dhadwal, Robert Gniadecki, Parbeer Grewal, Mark G. Kirchhof, Ian Landells, Perla Lansang, Chuck W. Lynde, Kim A. Papp, Yves Poulin, Gordon Sussman, Irina Turchin, Marni Wiseman and Jensen Yeung in Journal of Cutaneous Medicine and Surgery

Published
2018
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41. JCMS_Gooderham_803628 – Supplemental material for Approach to the Assessment and Management of Adult Patients With Atopic Dermatitis: A Consensus Document. Section II: Tools for Assessing the Severity of Atopic Dermatitis

Author

Gooderham, Melinda J., Bissonnette, Robert, Parbeer Grewal, Lansang, Perla, Papp, Kim A., and Chih-Ho Hong

Subjects
body regions, Medicine
Abstract

Supplemental material, JCMS_Gooderham_803628 for Approach to the Assessment and Management of Adult Patients With Atopic Dermatitis: A Consensus Document. Section II: Tools for Assessing the Severity of Atopic Dermatitis by Melinda J. Gooderham, Robert Bissonnette, Parbeer Grewal, Perla Lansang, Kim A. Papp and Chih-ho Hong in Journal of Cutaneous Medicine and Surgery

Published
2018
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42. 1329_Section_V_Supplementary_Table_1 – Supplemental material for Approach to the Assessment and Management of Adult Patients With Atopic Dermatitis: A Consensus Document. Section V: Consensus Statements on the Assessment and Management of Adult Patients With Moderate-to-Severe Atopic Dermatitis

Author

Chih-Ho Hong, Gooderham, Melinda J., Albrecht, Lorne, Bissonnette, Robert, Gurbir Dhadwal, Gniadecki, Robert, Parbeer Grewal, Kirchhof, Mark G., Landells, Ian, Lansang, Perla, Lynde, Chuck W., Papp, Kim A., Poulin, Yves, Sussman, Gordon, Turchin, Irina, Wiseman, Marni, and Jensen Yeung

Subjects
Medicine
Abstract

Supplemental material, 1329_Section_V_Supplementary_Table_1 for Approach to the Assessment and Management of Adult Patients With Atopic Dermatitis: A Consensus Document. Section V: Consensus Statements on the Assessment and Management of Adult Patients With Moderate-to-Severe Atopic Dermatitis by Chih-ho Hong, Melinda J. Gooderham, Lorne Albrecht, Robert Bissonnette, Gurbir Dhadwal, Robert Gniadecki, Parbeer Grewal, Mark G. Kirchhof, Ian Landells, Perla Lansang, Chuck W. Lynde, Kim A. Papp, Yves Poulin, Gordon Sussman, Irina Turchin, Marni Wiseman and Jensen Yeung in Journal of Cutaneous Medicine and Surgery

Published
2018
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43. Approach to the Assessment and Management of Adult Patients With Atopic Dermatitis: A Consensus Document

Author

Gooderham, Melinda J., primary, Hong, Chih-ho, additional, Albrecht, Lorne, additional, Bissonnette, Robert, additional, Dhadwal, Gurbir, additional, Gniadecki, Robert, additional, Grewal, Parbeer, additional, Kirchhof, Mark G., additional, Landells, Ian, additional, Lansang, Perla, additional, Lynde, Chuck W., additional, Papp, Kim A., additional, Poulin, Yves, additional, Sussman, Gordon, additional, Turchin, Irina, additional, Wiseman, Marni, additional, and Yeung, Jensen, additional

Published
2018
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44. Approach to the Assessment and Management of Adult Patients With Atopic Dermatitis: A Consensus Document. Section V: Consensus Statements on the Assessment and Management of Adult Patients With Moderate-to-Severe Atopic Dermatitis

Author

Hong, Chih-ho, primary, Gooderham, Melinda J., additional, Albrecht, Lorne, additional, Bissonnette, Robert, additional, Dhadwal, Gurbir, additional, Gniadecki, Robert, additional, Grewal, Parbeer, additional, Kirchhof, Mark G., additional, Landells, Ian, additional, Lansang, Perla, additional, Lynde, Chuck W., additional, Papp, Kim A., additional, Poulin, Yves, additional, Sussman, Gordon, additional, Turchin, Irina, additional, Wiseman, Marni, additional, and Yeung, Jensen, additional

Published
2018
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45. Generalized granuloma annulare treated with mycophenolate mofetil.

Author

Lansang, Rafael Paolo, Xiong, Grace, and Lansang, Perla

Subjects
MYCOPHENOLIC acid, SARCOIDOSIS, GRANULOMA, INFORMED consent (Medical law)
Abstract

Although the pathogenesis of GA is not fully understood, the inhibition of T lymphocytes by MMF likely leads to a reduction in the inflammatory response that underlies GA lesions. Granuloma annulare (GA) is a benign inflammatory condition with an etiology that is not fully understood. [Extracted from the article]

Published
2023
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