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23. Lo sconto bancario

Author

Antonucci, A, Appio C L, Bonfatti, S, Brozzetti, A, Camardi, C., Caputo Nassetti, F, Cardarelli, M C, Chessa, C, Corrias, P, Corvese, C G, De Angelis, L, Demuro, I, Desiderio, G, Di Brina, L, Inzitari, B, Lacaita, L, Lanotte, M, Lemma, V, Lener, R, Lucantoni, P, Manente, D, Martina, G, Moliterni, F, Motti, C, Nervi, A, Paracompo, M T, Pellegrini, M, Pistritto, M, Rispoli Farina, M, Russo, B, Sabbatelli, I, Sacco Ginevri, A, Sartori, F, Senigaglia, R, Sepe, M, Sicchiero, G, Sirena, P, Tola, M, Urbani, A, Alberto Urbani, Demuro, Ivan, Demuro, I (ORCID:0000-0002-7471-1353), Antonucci, A, Appio C L, Bonfatti, S, Brozzetti, A, Camardi, C., Caputo Nassetti, F, Cardarelli, M C, Chessa, C, Corrias, P, Corvese, C G, De Angelis, L, Demuro, I, Desiderio, G, Di Brina, L, Inzitari, B, Lacaita, L, Lanotte, M, Lemma, V, Lener, R, Lucantoni, P, Manente, D, Martina, G, Moliterni, F, Motti, C, Nervi, A, Paracompo, M T, Pellegrini, M, Pistritto, M, Rispoli Farina, M, Russo, B, Sabbatelli, I, Sacco Ginevri, A, Sartori, F, Senigaglia, R, Sepe, M, Sicchiero, G, Sirena, P, Tola, M, Urbani, A, Alberto Urbani, Demuro, Ivan, and Demuro, I (ORCID:0000-0002-7471-1353)

Abstract

Si analizza la disciplina del contratto di sconto bancario in tutti i suoi elementi costitutivi dando atto delle applicazioni nell'attività commerciale

Published
2020

42. Comparison of Allogeneic and Syngeneic Rat Glioma Models by Using MRI and Histopathologic Evaluation

Author

Biasibetti, E., Valazza, A., Capucchio, M. T., Annovazzi, L., Battaglia, L., Chirio, D., Gallarate, M., Mellai, M., Elisabetta MUNTONI, Peira, E., Riganti, C., Schiffer, D., Panciani, P., and Lanotte, M.

Subjects
Rat Models, Isografts, Reproducibility of Results, Glioma, Allografts, Magnetic Resonance Imaging, Rats, Inbred F344, Rats, Disease Models, Animal, CNS, Brain Glioma Model, Animals, Rats, Wistar
Abstract

Research in neurooncology traditionally requires appropriate in vivo animal models, on which therapeutic strategies are tested before human trials are designed and proceed. Several reproducible animal experimental models, in which human physiologic conditions can be mimicked, are available for studying glioblastoma multiforme. In an ideal rat model, the tumor is of glial origin, grows in predictable and reproducible patterns, closely resembles human gliomas histopathologically, and is weakly or nonimmunogenic. In the current study, we used MRI and histopathologic evaluation to compare the most widely used allogeneic rat glioma model, C6-Wistar, with the F98-Fischer syngeneic rat glioma model in terms of percentage tumor growth or regression and growth rate. In vivo MRI demonstrated considerable variation in tumor volume and frequency between the 2 rat models despite the same stereotactic implantation technique. Faster and more reproducible glioma growth occurred in the immunoresponsive environment of the F98-Fischer model, because the immune response is minimized toward syngeneic cells. The marked inability of the C6-Wistar allogeneic system to generate a reproducible model and the episodes of spontaneous tumor regression with this system may have been due to the increased humoral and cellular immune responses after tumor implantation.

Published
2017

48. The placebo effect on bradykinesia in Parkinson's disease with and without prior drug conditioning

Author

Frisaldi, E., Carlino, E., Zibetti, M., Barbiani, Diletta, Dematteis, F., Lanotte, M., Lopiano, L., Benedetti, F., Barbiani D., Frisaldi, E., Carlino, E., Zibetti, M., Barbiani, Diletta, Dematteis, F., Lanotte, M., Lopiano, L., Benedetti, F., and Barbiani D.

Abstract

Background: Placebo effects represent a major drawback in clinical trials, and their magnitude hampers the development of new treatments. Previous research showed that prior exposure to active treatments increases the placebo response for muscle rigidity in Parkinson's disease.Methods: We investigated the effects of prior exposure to apomorphine on the placebo response of another cardinal symptom of Parkinson's disease, bradykinesia, by a movement time analyzer.Results: We found no placebo response if the placebo was given for the first time, whereas the placebo response was substantial after prior pharmacological conditioning with apomorphine.Conclusions: These findings indicate that prior exposure to drugs is a critical factor in the occurrence and magnitude of placebo effects. These learning effects should be carefully assessed in clinical trials in which patients receive the active treatment first and then are randomized. Indeed, this sequence may generate high placebo responders. (c) 2017 International Parkinson and Movement Disorder Society

Published
2017

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