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This study aims to evaluate the antihistaminic potential of the plant extract from Lannea coromandelica using both in vitro and in vivo models. In vitro antihistaminic effects were studied using isolated guinea pig ileum to assess dose-dependent inhibitory impacts on histamine-induced contractions. Mast cell density was evaluated using a mast cell count model, calculating the average number of mast cells per unit area in the mesentery. For in vivo assessments, a histamine aerosol-induced bronchospasm model in guinea pigs was used, where pre-convulsive dyspnea (PCD) onset time was noted as pre-convulsive time (PCT). Additionally, a clonidine-induced mast cell degranulation model in rats was employed, with cells stained using 1% toluidine blue to count intact and degranulated mast cells. The Lannea coromandelica extract exhibited a dose-dependent inhibition of histamineinduced contractions in isolated guinea pig ileum. Similarly, the extract inhibited mast cell degranulation in a dosedependent manner, with a higher dose of 400 mg/kg proving more effective than a lower dose of 200 mg/kg. Acute toxicity studies confirmed the safety of the extract at moderate doses, revealing no toxic symptoms at a dosage of 2000 mg/kg body weight. Importantly, the extract significantly increased PCT in guinea pigs and reduced the percentage of disrupted mast cells induced by clonidine. Lannea coromandelica shows promising antihistaminic properties, effectively inhibiting histamine-induced bronchospasm and mast cell degranulation, which can be an option for the development of antiasthmatic drugs. [ABSTRACT FROM AUTHOR]

In this article, Grewia Optiva fiber (GOF) has been reinforced with epoxy and hybrid (epoxy-Lannea Coromandelica gum) resins. The biocomposite has been fabricated with 5, 10, and 15 weight% of continuous and discontinuous GOFs. The effect of fiber surface treatment has been examined on the mechanical properties of GOF. Additionally, the mechanical properties along with physicochemical, morphological, and thermal characterization have been determined for GOF reinforced composites. The results have revealed that GOF treated with 5% NaOH has shown superior tensile strength. Also, the increase in fiber content has increased the water absorption, and it has been maximum for 15 wt% GOF reinforced hybrid resin composites. Further, the stress-strain behaviors under tensile and flexural load have confirmed that 15 wt% continuous GOF reinforcement with epoxy resin has shown maximum tensile strength and flexural strength. In Charpy impact test, 15 wt% GOF reinforcement with hybrid resin has shown the best results compared to their counterparts. The spectroscopy has confirmed the interaction between resins and GOF. The morphological analysis has confirmed the porous structure and inter-connected open cavities with unique hollow and multiscale structures of GOF. The fractured surface of composites under tensile and flexural loading has confirmed the fiber-matrix debonding, fiber breaking, and microcracking. Also, no gaps or pull outs confirming the good interfacial adhesion between fiber and matrix. The thermal analyses have shown the low thermal stability of composites and the lower values of glass transition temperature for composites in comparison to pure resins. Further, this work can expose a fresh way to implement locally accessible eco-friendly natural fiber and resins to produce high-performance biocomposites. The utilization of agricultural by-product as a sustainable green composite can resolve the problem of disposal of these materials and maintain an eco-friendly environment. These composites could be suitable for buildings, automotive parts, sound barriers, marine parts, etc. [ABSTRACT FROM AUTHOR]

In this paper, the Grewia Optiva fibers (GOFs) have been used as reinforcement in two different polymers, i.e., epoxy resin and epoxy-llLannea Coromandelica (LC) resin, and the acoustic properties of GOFs, resins, and their composites have been investigated. Normally, the sound absorption coefficient (SAC) bigger than 0.2 for any material qualifies it as a sound absorbing material. Recently, green or natural materials have been progressively investigated for use in sound absorption for greater environmental sustainability and bio-waste management. The 30 mm-thick samples (pure and composite) have been fabricated and characterized for acoustic properties by an Impedance tube. The SAC of the fabricated samples has been obtained and discussed in detail with reasoning. The SAC of GOFs have been compared with other natural fibers. Similarly, the GOF reinforced composite has been compared with other natural fiber-reinforced composites and concluded that the SAC of composites increase with the increment of the fiber contents. The GOF reinforced epoxy-LC composites have shown higher SAC as compared to other counterparts. Moreover, the SAC of GOF has also been calculated by empirical (Delany-Bazley, Miki, and Garai-Pompoli) and phenomenological (Johnson-Champoux-Allard) models and compared with experimental results. The findings have revealed the possibility of natural resin as a substitute for synthetic resins for a better economic and environmental sustainability. [ABSTRACT FROM AUTHOR]

In this present study, silver nanoparticles (AgNPs) were synthesized through an easy, rapid, and eco-friendly pathway using Lannea coromandelica aqueous bark extract. The obtained AgNPs were characterized using Ultraviolet-Visible (UV-Vis) spectrophotometer, Fourier Transform Infrared (FTIR), X-ray Diffraction (XRD), and Scanning Electron Microscope (SEM). The results indicated that the pH of colloidal AgNPs played a vital role in forming AgNPs. The pH ranges used in this study were 6, 8, 10, and 12. The formation of AgNPs was confirmed by observing the surface plasmon resonance (SPR) band at each pH and obtaining a wavelength of 430.50, 419.50, 418.50, and 410.00 nm. A comparison of the FTIR spectra of Lannea coromandelica aqueous bark extract and AgNPs showed the contribution of the O-H group in reducing silver ions. XRD diffractogram showed that AgNPs formed at 2θ = 37.8056o (1 1 1), 44.0345o (2 0 0), 64.3942o (2 2 0), dan 77.5003o (3 1 1) with face-centered cubic (FCC) crystal structure, and the average particle size was 22.5047 nm. SEM results showed that the nanoparticles have a non-uniform and irregular shape.

Phytochemical screening was conducted on various bark extracts of Lannea coromandelica to assess their anticancer property against the B16F10 melanoma cell line. The phytoconstituents that were previously identified were utilized in molecular docking studies against the human tyrosinase related protein 1 (TYRP1) as a target receptor in order to provide more evidence for anticancer property. Bark powder was extracted by maceration method using distilled water and soxhlet extraction using ethanol. The preliminary phytochemical evaluation and determination of total phenolic and flavonoid content of both extracts were conducted using biochemical assays. The present study investigated the possible anticancer effects of ethanol and aqueous extracts on the B16F10 melanoma cell line using the 3-4,5-dimethylthiazol-2-yl-2,5-diphenyl tetrazolium bromide (MTT) assay and 4,6-diamidino-2-phenylindole (DAPI) labeling techniques. The present study employed molecular docking techniques to assess the binding interactions between phytoconstituents and the TYRP1 protein, utilizing AutoDock Vina module of PyRx 0.8 software. The phytochemical analysis found flavonoids, steroids, terpenoids, tannins, phenolic compounds, saponins, anthraquinones, cardiac glycosides, and proteins. Ethanolic extract shown preferential cytotoxicity to B16F0 melanoma cell line in-vitro (IC 50 = 9.69 ± 0.68 μg/ml), while aqueous extract exhibited IC 50 = 75.49 ± 5.95 μg/ml. DAPI staining showed that treated cells had altered nucleus morphology, including apoptotic bodies. According to molecular docking investigations, Quercetin has the highest binding affinity (−9.6 Kcal/mol), followed by Catechin and Myricadiol. The current investigation has determined that L. coromandelica exhibits cytotoxic characteristic, as evidenced by the utilization of computer aided drug design models and in-vitro experimentation. [ABSTRACT FROM AUTHOR]

This study determined the efficacy of extract of the stem bark of Lannea coromandelica (ESBLc) on histopathology and inflammatory cell infiltration in the gastric of rats induced by mefenamic acid. We grouped 20 rats (Rattus norvegicus) into 5; Group 1 (positive control, mefenamic acid + sucralfate suspension), Group 2 (negative control, mefenamic acid), Group 3 (mefenamic acid + ESBLc 1575 mg/kg), Group 4 (mefenamic acid + ESBLc 3150 mg/kg), and Group 5 (mefenamic acid + ESBLc 3600 mg/kg). The dose of mefenamic acid used was 23.25 mg/kg, given orally for 7 days. Gastric histopathological observations were carried out qualitatively, and inflammatory cell infiltration was analyzed quantitatively by one-ay ANOVA. The qualitative and quantitative analysis results showed that ESBLc had efficacy in restoring damaged gastric tissue of rats; statistically, 3150 mg/kg and 6300 mg/kg effectively reduced inflammatory cell infiltration. ESBLc recovered the function of gastric organs of Rattus norvegicus L. induced by mefenamic acid, including improved mucosa and reduced inflammatory cell infiltration in the gastric. The doses of ESBLc, which effectively reduced inflammatory cell infiltrations, were 3150 mg/kg and 6300 mg/kg BW.

This study determined the efficacy of extract of the stem bark of Lannea coromandelica (ESBLc) on histopathology and inflammatory cell infiltration in the gastric of rats induced by mefenamic acid. We grouped 20 rats (Rattus norvegicus) into 5; Group 1 (positive control, mefenamic acid + sucralfate suspension), Group 2 (negative control, mefenamic acid), Group 3 (mefenamic acid + ESBLc 1575 mg/kg), Group 4 (mefenamic acid + ESBLc 3150 mg/kg), and Group 5 (mefenamic acid + ESBLc 3600 mg/kg). The dose of mefenamic acid used was 23.25 mg/kg, given orally for 7 days. Gastric histopathological observations were carried out qualitatively, and inflammatory cell infiltration was analyzed quantitatively by one-ay ANOVA. The qualitative and quantitative analysis results showed that ESBLc had efficacy in restoring damaged gastric tissue of rats; statistically, 3150 mg/kg and 6300 mg/kg effectively reduced inflammatory cell infiltration. ESBLc recovered the function of gastric organs of Rattus norvegicus L. induced by mefenamic acid, including improved mucosa and reduced inflammatory cell infiltration in the gastric. The doses of ESBLc, which effectively reduced inflammatory cell infiltrations, were 3150 mg/kg and 6300 mg/kg BW. [ABSTRACT FROM AUTHOR]

Hybrid composites are formed by the combination of natural fibers (pineapple, silk, flax etc.) and synthetic fibers (glass) reinforced polymer or hybrid or natural resin matrix composites which have specific mechanical properties due to contents of renewability, recyclability, and biodegradability compared to synthetic fibers. Lannea coromandelica (LC, Anacardiaceae plant gum) is blended with Epoxy (synthetic polymer matrix resin) to form hybrid Lannea Coromandelica Blender Epoxy matrix (LCE) resin composites for the replacement of epoxy resin to improve the biodegradability and environmental friendly nature. NaOH treated and untreated hybrid Composites (Pineapple (PGP)/Silk (SGS)/Flax (FGF) fiber mats with 2%, 4%, 6% volume fraction of Bentonite nanoclay (BNC) nano filler loading in each composition reinforcement in hybrid LCE resin) and hybrid LCE resin are prepared by Compression hand molding technique method. The maximum mechanical properties are observed for treated P/G/P fiber mats with 2%, 4%, 6% volume fraction BNC filler reinforced LCE resin matrix. Mechanical properties such as tensile properties, flexural properties and impact strength of hybrid composites have improved three to four times compared to hybrid LCE resin. Results of dynamic mechanical analysis (DMA) show that untreated and treated hybrid composites have the highest storage modulus (stiffness and adsorption energy) and the lowest damping factor (Tan δ) when compared to hybrid LCE resin. Biodegradability testing has revealed that adding 4 percent volume fraction of nano filler to treated P/G/P fiber mats reinforced LCE resin composite resulting in minimal weight loss over a long period of time.

Herbal medicine as a traditional medicine based on local wisdom in the Covid 19 pandemic is the alternative for the community to keep the health of the body. Specific drugs for the cure of Covid-19 disease have also not been found yet so the death of Covid-19 patients remainsat anytime. In this case this study aims to know the content of secondary metabolite compounds and radical scavenger activity of “kayu jawa” (L. coromandelica) leaf steeping and “Salam” (S. polyanthum) leaves from Southeast Sulawesi as well as their rational combination based on the radical scavenger activity of DPPH (2,2-difenyl-1-picrilhydrazil). The analysis of the content of secondary metabolite compounds in the steeping of DKJ (Daun Kayu Jawa) and DS (Daun Salam) is applied by phytochemical method and radical scavenger activity is determined by the DPPH method. The main focus of steeping is determined by the approach of the picnometer. The combination of DKJ and DS is made each with 6 variations based on the IC50 steeping value, then converted in the form of weight (grams) of DKJ and DS powder so that 36 combinations are obtained. The result of phytochemical analysis of DKJ and DS steeping showed the presence of flavonoids, saponins and polyphenols, except tannins only exist in the steeping of DS. The radical scavenger activity of DKJ and DS steeping showed IC50 values of 408.95 ± 0.075 µg/mL and 259.05 ± 0.092 µg/mL. The combination that showed the highest DPPH radical scavenger activity of 88.050.03% occurred in the combination of E1 with a ratio of 2IC50 DK: 1/8IC50DS (1,089: 0.128) grams. DPPH radical scavenger activity approaching 50% occurs in the combination of A2 and B1 with a ratio of 1/8IC50 DKJ: ¼IC50DS (0.068:0.256) grams and ¼IC50 DKJ: 1/8IC50DS (0.136:0.128) grams with values of (49.11 0.04) % and (52.87 0.05) % respectively.

As an alternative to synthetic preservatives, the use of plant-based, environmentally sustainable preservatives for wood protection has tremendous potential. The current research analyzed the dimensional stability and longevity of Lannea coromandelica wood using weed extracts viz. Lantana camara L. and Ageratum conyzoides L., respectively. Petroleum ether (PE) and methanolic weed extracts were used to treat wood blocks (5 cm × 2.5 cm × 2.5 cm) at varying concentrations ranging from 0.25 to 2.00%. The PE extract of A. conyzoides resulted in maximum swelling (tangential plane, 6.30%) at 2.00%, volumetric swelling coefficient (13.17%) at 1.50%, and volumetric shrinkage coefficient (7.71%) at 1.00% concentration, while maximum shrinkage (tangential plane, 4.10%) in methanol (M) extract was observed. In L. camara methanolic extract (1.00%), maximum anti-shrink efficiency (37.01%) was recorded. In vitro mycelial growth of the wood-rotting fungus was completely inhibited by PE extract from both weeds. However, the methanolic extract of A. conyzoides resulted in maximal inhibition (75.93%) at a concentration of 2.00%. Also, PE extract (2.00%) of A. conyzoides reduced the fungal colonization to 50%, as compared with control. The lowest weight loss (decay test, 12 weeks) was observed at a 2.00% concentration of L. camara PE extract. The present research highlighted that both A. conyzoides and L. camara could be used as an environmentally sustainable wood preservative substitute that will encourage the utilization of L. coromandelica in wood-based industries.

As an alternative to synthetic preservatives, the use of plant-based, environmentally sustainable preservatives for wood protection has tremendous potential. The current research analyzed the dimensional stability and longevity of Lannea coromandelica wood using weed extracts viz. Lantana camara L. and Ageratum conyzoides L., respectively. Petroleum ether (PE) and methanolic weed extracts were used to treat wood blocks (5 cm × 2.5 cm × 2.5 cm) at varying concentrations ranging from 0.25 to 2.00%. The PE extract of A. conyzoides resulted in maximum swelling (tangential plane, 6.30%) at 2.00%, volumetric swelling coefficient (13.17%) at 1.50%, and volumetric shrinkage coefficient (7.71%) at 1.00% concentration, while maximum shrinkage (tangential plane, 4.10%) in methanol (M) extract was observed. In L. camara methanolic extract (1.00%), maximum anti-shrink efficiency (37.01%) was recorded. In vitro mycelial growth of the wood-rotting fungus was completely inhibited by PE extract from both weeds. However, the methanolic extract of A. conyzoides resulted in maximal inhibition (75.93%) at a concentration of 2.00%. Also, PE extract (2.00%) of A. conyzoides reduced the fungal colonization to 50%, as compared with control. The lowest weight loss (decay test, 12 weeks) was observed at a 2.00% concentration of L. camara PE extract. The present research highlighted that both A. conyzoides and L. camara could be used as an environmentally sustainable wood preservative substitute that will encourage the utilization of L. coromandelica in wood-based industries. [ABSTRACT FROM AUTHOR]

Lannea coromandelica (Houtt.) Merr. is a deciduous tree in the family Anacardiaceae, which grows in lowland and hill forests; 100–1800 m. SW Guangdong, S Guangxi, S Yunnan [Bhutan, India, Myanmar, Nepal, Sri Lanka; cultivated elsewhere in continental SE Asia, such as in Cambodia, Laos, Malaysia, Thailand, Vietnam, where it is probably naturalized]. The length of the complete plastome is 162,460 bp, including 130 genes consisting of 85 protein-coding genes, 37 tRNA genes and 8 rRNA genes. The assembled plastome has the typical structure and gene content of angiosperms plastome, which includes two inverted repeats (IRs) regions of 26,877 bp, a large single copy (LSC) region of 89,599 bp and a small single-copy (SSC) region of 19,107 bp. The total G/C content in the plastome of L. coromandelica is 37.7%. The complete plastome sequence of L. coromandelica will provide contributions to the conservation genetics of this species as well as to phylogenetic studies in Anacardiaceae.

Lannea coromandelica leaf extract (LCLE) as a corrosion inhibitor in 1 M H2SO4 was investigated by weight loss and electrochemical techniques. Inhibition efficiency of LCLE was found to increase with increasing concentration but decreased with increasing temperature. Polarization measurements revealed that the LCLE acted as a mixed type inhibitor. Nyquist plots showed that on increasing the LCLE concentration, the charge transfer resistance increased and the double layer capacitance decreased. The adsorption of LCLE on mild steel obeyed the Langmuir adsorption isotherm. FT-IR, XRD, SEM and AFM techniques confirmed the adsorption of LCLE on mild steel surface.

The present study was undertaken to contribute to the continuous search for efficient protocol for the macropropagation of Lannea coromandelica. It investigates the main factors involved in the macropropagation process, namely cutting type, rooting medium composition and rooting hormones at nursery conditions. Among this study identified that soft wood cutting as the ideal propagating material for mass multiplication of Lannea coromandelica genetic resources and also IBA at 3000 ppm as the optimal rooting hormone and sand and soil as the ideal potting media for clonal propagation. [ABSTRACT FROM AUTHOR]

The leaves of Lannea coromandelica (Houtt.) Merr. are used in the Garo, Pahan, and Teli tribal communities of Bangladesh as a traditional medicinal plant to treat hepatitis, diabetes, ulcers, heart disease, and dysentery. However, there have been limited phytochemical and biological studies on the bark of L. coromandelica. This study aimed to investigate the antioxidant activities of L. coromandelica bark extract (LCBE) and the underlying mechanism using RAW 264.7 cells. The LCBE was analysed by high-pressure liquid chromatography (HPLC) to detect its key polyphenolic compounds. Various in vitro antioxidant assays were performed using RAW264.7 cells to assess the antioxidant effects of the LCBE and to understand the underlying molecular mechanism. HPLC revealed the presence of gallic acid, (-)-epigallocatechin-3-gallate, catechin, chlorogenic acid, and caffeic acid in the LCBE. The extract showed a very potent capacity to scavenge numerous free radicals through hydrogen atom transfer and/or electron donation and also quenched cellular reactive oxygen species (ROS) generation without showing any toxicity. The LCBE was found to combat the oxidative stress by enhancing the expression, at both transcriptional and translational levels, of primary antioxidant enzymes as well as phase II detoxifying enzymes, especially heme oxygenase 1, through the upregulation of the nuclear factor erythroid 2-related factor 2 (NRF2)-mediated pathway in RAW 264.7 cells via the phosphorylation of p38 kinase and c-Jun N-terminal kinase (JNK). The LCBE exhibited strong antioxidant activities and mitigated the cellular ROS production. These results provide scientific evidence of its potential as an ideal applicant for a cost-effective, readily available, and natural phytochemical, as well as a strategy for preventing diseases associated with oxidative stress and attenuating disease progress. [ABSTRACT FROM AUTHOR]

Background: Ayurvedic text reports suggested Lannea coromandelica is used in various microbial origin disorders like dysentery, sore eyes and leprosy, genital wounds. Objective: The present study was designed to investigate the antimicrobial effect of L. coromandelica Houtt. Merrill. (Anacardiaceae) on microbes which cause female reproductive tract infection. Materials and Methods: Ethanolic and aqueous bark extract (Ext.) of L. coromandelica were screened against strains of Streptococcus pyogens, Staphylococcus aureus, and Candida albicans. Antimicrobial assay had been done with agar well diffusion method. Results: Ethanolic extracts [100% (16 mg), 75% (12 mg) and 50% (8 mg)] of L. coromandelica exhibited zone of inhibition (ZI) 19.21 mm, 18.45 mm, 16.41 mm and 18.12 mm, 17.35 mm, 16.35 mm against S. aureus and S. pyogens, respectively. However, only 100% and 75% ethanolic extract showed (ZI-19.18 mm, 16.29 mm) activity against C. albicans. Nevertheless, aqueous extract (100%) showed higher antifungal activity (ZI-16.97 mm). Ciprofloxacin and amphotericin B were used as a standard drugs in the present study. Conclusion: The results demonstrated that L. coromandelica Houtt. Merrill. have antibacterial activity against S. pyogens, S. aureus and antifungal property against C. albicans. Our findings corroborate the ethnobotanical use of L. coromandelica in traditional medicine system (Ayurveda) of India.

Arabinogalactan proteins (AGPs) are heavily glycosylated proteoglycans in plants. The structural complexity of their glycan portion hampers the assignment of the arabinogalactan protein function and limits their uses. Herein, we report finer structural details of the AGP of Lannea grandis gum based on libraries of oligosaccharides released by Smith degradation, enzyme digestion and partial acid hydrolysis. Application of NMR spectroscopy to the parental AGP, which contained 95% carbohydrate and 3% protein, in combination with chemical, chromatographic and ESI-MS data on oligosaccharides generated allowed direct information on glycosidic linkage type, ring size, anomeric configuration and sequence of saccharide residues. Finally, this AGP shows dose-dependent free radical scavenging activity as well as forms water soluble complex (K = 3.32 × 10 6 /M) with β -lactoglobulin ( β -lg) at pH (2–7). [ABSTRACT FROM AUTHOR]

Background: Herbal plants are a preferred source of anticancer agents. This study aims to screen the anticancer activity of a crude extract of twigs of (a) Bombaxanceps Pierre var. anceps (BA); (b) Catunaregam tomentosa (Blume ex DQTirveng. (CT); (c) Erythrophleum succirubrum Gagnep. (ES); (d) Lannea coromandelica (Houtt.) Merr. (LC); and (e) leaves and (f) twigs of Diospyros castanea (Craib) Fletcher (DC). Methods: The 50 % ethanol-water extracts were prepared from each plant sample. In vitro anticancer effects of six extracts on the human hepatocellular carcinoma cell line (HepG2) in terms of cytotoxicity were investigated by neutral red assay, apoptosis induction by 4',6-diamidino-2-phenylindole (DAPI) staining, and DNA fragmentation by agarose gel electrophoresis. Normal Vero cells were tested for comparison and to determine cancer selectivity. Gas chromatography-mass spectrometry analysis was performed to identify the compounds in the extracts. Results: The six crude extracts had different cytotoxicities and were classified into three groups based on their IC50 value and selectivity index (SI). DC (twig) crude extract had both a high cytotoxicity and SI toward HepG2 cells comparable to melphalan (P = 0.023). The crude extracts of DC (leaves), LC (twig), and BA (twig) had moderate cytotoxicity and a lower SI. Although all crude plant extracts induced apoptosis in more than 50 % of the DAPI-positive apoptotic HepG2 cells, only DC (twig) and LC (twig) showed laddering in the DNA fragmentation assay. 2-Palmitoylglycerol was the major compound common to both. Pyrogallol and lupeol were the major compounds in DC (twig) crude extract. Hexadecanoic acid and octadecenoic acid were the major compounds in LC (twig) crude extract, which had high toxicity but low selectivity. Conclusion: Ethanolic extracts from DC and LC twigs induced apoptosis in the HepG2 cell line. Pyrogallol and lupeol in DC (twig) might be responsible for the cytotoxicity toward the HepG2 cancer cells. [ABSTRACT FROM AUTHOR]

The objective of this present study was to investigate binder property of Lannea coromandelica in tablet formulations and its comparative binding property with povidone as standard binder. All the eight tablet batches (F-1 to F-8) were prepared by wet granulation technique. Microcrystalline cellulose (Prosolv SM) as diluent, diclofenac sodium as model drug using 4, 6, 8 and 10% of L. coromandelica gum used as a novel binder, magnesium stearate used as an antiadherent and talc used as lubricant. Micromeritic properties of granules such as bulk density, tapped density, compressibility index, Hausner's ratio, angle of repose as well as physical parameters of the compressed tablets like hardness, friability, thickness and disintegration time were determined and found to be satisfactory. The Fourier transform infrared spectroscopic analysis showed that the tablet formulation containing L. coromandelica gum is compatible with the drug and other excipients, which are used in the tablet formulation. Thus, concluded that L. coromandelica gum has role as a potential binder in tablets formulations. The in vitro drug release profile concluded that tablets formulations containing L. coromandelica gum 20 mg/200 mg of total weight of tablet as binder showed better results as compared to povidone as standard binder. [ABSTRACT FROM AUTHOR]

Lannea coromandelica (Houtt.) Merr. is a deciduous tree in the family Anacardiaceae, which grows in lowland and hill forests; 100–1800 m. SW Guangdong, S Guangxi, S Yunnan [Bhutan, India, Myanmar, Nepal, Sri Lanka; cultivated elsewhere in continental SE Asia, such as in Cambodia, Laos, Malaysia, Thailand, Vietnam, where it is probably naturalized]. The length of the complete plastome is 162,460 bp, including 130 genes consisting of 85 protein-coding genes, 37 tRNA genes and 8 rRNA genes. The assembled plastome has the typical structure and gene content of angiosperms plastome, which includes two inverted repeats (IRs) regions of 26,877 bp, a large single copy (LSC) region of 89,599 bp and a small single-copy (SSC) region of 19,107 bp. The total G/C content in the plastome of L. coromandelica is 37.7%. The complete plastome sequence of L. coromandelica will provide contributions to the conservation genetics of this species as well as to phylogenetic studies in Anacardiaceae. [ABSTRACT FROM AUTHOR]

The aim of this study was to determine the impending antioxidant properties of different extracts of crude methanolic extract (CME) of leaves of Lannea coromandelica (L. coromandelica) and its two ethyl acetate (EAF) and aqueous (AqF) subfractions by employing various established in vitro systems and estimation of total phenolic and flavonoid content. The results showed that extract and fractions possessed strong antioxidant activity in vitro and among them, EAF had the strongest antioxidant activity. EAF was confirmed for its highest phenolic content, total flavonoid contents, and total antioxidant capacity. The EAF was found to show remarkable scavenging activity on 2,2-diphenylpicrylhydrazyl (DPPH) (EC50 63.9 ± 0.64 µg/mL), superoxide radical (EC50 8.2 ± 0.12 mg/mL), and Fe2+ chelating activity (EC50 6.2 ± 0.09 mg/mL). Based on our in vitro results, EAF was investigated for in vivo antioxidant assay. Intragastric administration of the EAF can significantly increase levels of superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and glutathione peroxidase (GSH-Px) levels, and decrease malondialdehyde (MDA) content in the liver and kidney of CCl4-intoxicated rats. These new evidences show that L. coromandelica bared antioxidant activity. [ABSTRACT FROM AUTHOR]

Antagonism of glucagon is a potential therapeutic approach for Type 2 diabetes mellitus (T2DM). The bark extract of Lannea coromandelica has been reported to have hypoglycemic or anti-diabetic effects on animal models and human subjects. The aim of this study was to elucidate the molecular mechanisms of L. coromandelica extract as a glucagon receptor antagonist. The aqueous extract of L . coromandelica bark attenuated glucagon-mediated cAMP formation in a concentration dependent manner with an IC 50 value of 4.24 ± 1.31 μg/ml. It shifted a concentration response curve of glucagon towards the right with a 4, 21 and 40-fold change in IC 50 at 6.25, 12.5 and 25 μg/ml of extract, respectively. Additionally, it attenuated an oxyntomodulin-mediated cAMP response. The extract was found specifically to inhibit glucagon mediated cAMP formation since it was ineffective in reducing cAMP levels nonspecifically-elevated by forskolin. The data support that the aqueous extract of L. coromandelica antagonizes the glucagon receptor and has the potential to reduce glucagon mediated liver glucose output. [ABSTRACT FROM AUTHOR]