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4. A consensus protocol for functional connectivity analysis in the rat brain

Author

Grandjean, Joanes, Desrosiers-Gregoire, Gabriel, Anckaerts, Cynthia, Angeles-Valdez, Diego, Ayad, Fadi, Barrière, David A., Blockx, Ines, Bortel, Aleksandra, Broadwater, Margaret, Cardoso, Beatriz M., Célestine, Marina, Chavez-Negrete, Jorge E., Choi, Sangcheon, Christiaen, Emma, Clavijo, Perrin, Colon-Perez, Luis, Cramer, Samuel, Daniele, Tolomeo, Dempsey, Elaine, Diao, Yujian, Doelemeyer, Arno, Dopfel, David, Dvořáková, Lenka, Falfán-Melgoza, Claudia, Fernandes, Francisca F., Fowler, Caitlin F., Fuentes-Ibañez, Antonio, Garin, Clément M., Gelderman, Eveline, Golden, Carla E. M., Guo, Chao C. G., Henckens, Marloes J. A. G., Hennessy, Lauren A., Herman, Peter, Hofwijks, Nita, Horien, Corey, Ionescu, Tudor M., Jones, Jolyon, Kaesser, Johannes, Kim, Eugene, Lambers, Henriette, Lazari, Alberto, Lee, Sung-Ho, Lillywhite, Amanda, Liu, Yikang, Liu, Yanyan Y., López -Castro, Alejandra, López-Gil, Xavier, Ma, Zilu, MacNicol, Eilidh, Madularu, Dan, Mandino, Francesca, Marciano, Sabina, McAuslan, Matthew J., McCunn, Patrick, McIntosh, Alison, Meng, Xianzong, Meyer-Baese, Lisa, Missault, Stephan, Moro, Federico, Naessens, Daphne M. P., Nava-Gomez, Laura J., Nonaka, Hiroi, Ortiz, Juan J., Paasonen, Jaakko, Peeters, Lore M., Pereira, Mickaël, Perez, Pablo D., Pompilus, Marjory, Prior, Malcolm, Rakhmatullin, Rustam, Reimann, Henning M., Reinwald, Jonathan, Del Rio, Rodrigo Triana, Rivera-Olvera, Alejandro, Ruiz-Pérez, Daniel, Russo, Gabriele, Rutten, Tobias J., Ryoke, Rie, Sack, Markus, Salvan, Piergiorgio, Sanganahalli, Basavaraju G., Schroeter, Aileen, Seewoo, Bhedita J., Selingue, Erwan, Seuwen, Aline, Shi, Bowen, Sirmpilatze, Nikoloz, Smith, Joanna A. B., Smith, Corrie, Sobczak, Filip, Stenroos, Petteri J., Straathof, Milou, Strobelt, Sandra, Sumiyoshi, Akira, Takahashi, Kengo, Torres-García, Maria E., Tudela, Raul, van den Berg, Monica, van der Marel, Kajo, van Hout, Aran T. B., Vertullo, Roberta, Vidal, Benjamin, Vrooman, Roël M., Wang, Victora X., Wank, Isabel, Watson, David J. G., Yin, Ting, Zhang, Yongzhi, Zurbruegg, Stefan, Achard, Sophie, Alcauter, Sarael, Auer, Dorothee P., Barbier, Emmanuel L., Baudewig, Jürgen, Beckmann, Christian F., Beckmann, Nicolau, Becq, Guillaume J. P. C., Blezer, Erwin L. A., Bolbos, Radu, Boretius, Susann, Bouvard, Sandrine, Budinger, Eike, Buxbaum, Joseph D., Cash, Diana, Chapman, Victoria, Chuang, Kai-Hsiang, Ciobanu, Luisa, Coolen, Bram F., Dalley, Jeffrey W., Dhenain, Marc, Dijkhuizen, Rick M., Esteban, Oscar, Faber, Cornelius, Febo, Marcelo, Feindel, Kirk W., Forloni, Gianluigi, Fouquet, Jérémie, Garza-Villarreal, Eduardo A., Gass, Natalia, Glennon, Jeffrey C., Gozzi, Alessandro, Gröhn, Olli, Harkin, Andrew, Heerschap, Arend, Helluy, Xavier, Herfert, Kristina, Heuser, Arnd, Homberg, Judith R., Houwing, Danielle J., Hyder, Fahmeed, Ielacqua, Giovanna Diletta, Jelescu, Ileana O., Johansen-Berg, Heidi, Kaneko, Gen, Kawashima, Ryuta, Keilholz, Shella D., Keliris, Georgios A., Kelly, Clare, Kerskens, Christian, Khokhar, Jibran Y., Kind, Peter C., Langlois, Jean-Baptiste, Lerch, Jason P., López-Hidalgo, Monica A., Manahan-Vaughan, Denise, Marchand, Fabien, Mars, Rogier B., Marsella, Gerardo, Micotti, Edoardo, Muñoz-Moreno, Emma, Near, Jamie, Niendorf, Thoralf, Otte, Willem M., Pais-Roldán, Patricia, Pan, Wen-Ju, Prado-Alcalá, Roberto A., Quirarte, Gina L., Rodger, Jennifer, Rosenow, Tim, Sampaio-Baptista, Cassandra, Sartorius, Alexander, Sawiak, Stephen J., Scheenen, Tom W. J., Shemesh, Noam, Shih, Yen-Yu Ian, Shmuel, Amir, Soria, Guadalupe, Stoop, Ron, Thompson, Garth J., Till, Sally M., Todd, Nick, Van Der Linden, Annemie, van der Toorn, Annette, van Tilborg, Geralda A. F., Vanhove, Christian, Veltien, Andor, Verhoye, Marleen, Wachsmuth, Lydia, Weber-Fahr, Wolfgang, Wenk, Patricia, Yu, Xin, Zerbi, Valerio, Zhang, Nanyin, Zhang, Baogui B., Zimmer, Luc, Devenyi, Gabriel A., Chakravarty, M. Mallar, and Hess, Andreas

Published
2023
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7. Spatio-Temporal Characterization of Brain Inflammation in a Non-human Primate Stroke Model Mimicking Endovascular Thrombectomy

Author

Becker, Guillaume, Debatisse, Justine, Rivière, Margaux, Crola Da Silva, Claire, Beaudoin-Gobert, Maude, Eker, Omer, Wateau, Océane, Cho, Tae Hee, Wiart, Marlène, Tremblay, Léon, Costes, Nicolas, Mérida, Inès, Redouté, Jérôme, Léon, Christelle, Langlois, Jean-Baptiste, Le Bars, Didier, Lancelot, Sophie, Nighoghossian, Norbert, Mechtouff, Laura, and Canet-Soulas, Emmanuelle

Published
2023
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9. Surface modification effect on contrast agent efficiency for X-ray based spectral photon-counting scanner/luminescence imaging: from fundamental study to in vivo proof of concept

Author

Cuau, Loic, primary, Akl, Pia, additional, Gautheron, A., additional, Houmeau, Angèle, additional, Chaput, Frédéric, additional, Yaromina, Ala, additional, Dubois, Ludwig, additional, Lambin, Philippe, additional, Karpati, Szilvia, additional, Parola, Stephane, additional, Rezaeifar, B., additional, Langlois, Jean-Baptiste, additional, Si-Mohamed, Salim A., additional, Montcel, Bruno, additional, Douek, Philippe, additional, and Lerouge, Frederic, additional

Published
2024
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10. The PREMISE database of 20 Macaca fascicularis PET/MRI brain images available for research

Author

Chalet, Lucie, primary, Debatisse, Justine, additional, Wateau, Oceane, additional, Boutelier, Timothe, additional, Wiart, Marlène, additional, Costes, Nicolas, additional, Mérida, Inés, additional, Redouté, Jérôme, additional, Langlois, Jean-Baptiste, additional, Lancelot, Sophie, additional, Léon, Christelle, additional, Cho, Tae-Hee, additional, Mechtouff, Laura, additional, Eker, Omer Faruk, additional, Nighoghossian, Norbert, additional, Canet-Soulas, Emmanuelle, additional, and Becker, Guillaume, additional

Published
2023
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11. Author Correction: A consensus protocol for functional connectivity analysis in the rat brain

Author

Grandjean, Joanes, primary, Desrosiers-Gregoire, Gabriel, additional, Anckaerts, Cynthia, additional, Angeles-Valdez, Diego, additional, Ayad, Fadi, additional, Barrière, David A., additional, Blockx, Ines, additional, Bortel, Aleksandra, additional, Broadwater, Margaret, additional, Cardoso, Beatriz M., additional, Célestine, Marina, additional, Chavez-Negrete, Jorge E., additional, Choi, Sangcheon, additional, Christiaen, Emma, additional, Clavijo, Perrin, additional, Colon-Perez, Luis, additional, Cramer, Samuel, additional, Daniele, Tolomeo, additional, Dempsey, Elaine, additional, Diao, Yujian, additional, Doelemeyer, Arno, additional, Dopfel, David, additional, Dvořáková, Lenka, additional, Falfán-Melgoza, Claudia, additional, Fernandes, Francisca F., additional, Fowler, Caitlin F., additional, Fuentes-Ibañez, Antonio, additional, Garin, Clément M., additional, Gelderman, Eveline, additional, Golden, Carla E. M., additional, Guo, Chao C. G., additional, Henckens, Marloes J. A. G., additional, Hennessy, Lauren A., additional, Herman, Peter, additional, Hofwijks, Nita, additional, Horien, Corey, additional, Ionescu, Tudor M., additional, Jones, Jolyon, additional, Kaesser, Johannes, additional, Kim, Eugene, additional, Lambers, Henriette, additional, Lazari, Alberto, additional, Lee, Sung-Ho, additional, Lillywhite, Amanda, additional, Liu, Yikang, additional, Liu, Yanyan Y., additional, López -Castro, Alejandra, additional, López-Gil, Xavier, additional, Ma, Zilu, additional, MacNicol, Eilidh, additional, Madularu, Dan, additional, Mandino, Francesca, additional, Marciano, Sabina, additional, McAuslan, Matthew J., additional, McCunn, Patrick, additional, McIntosh, Alison, additional, Meng, Xianzong, additional, Meyer-Baese, Lisa, additional, Missault, Stephan, additional, Moro, Federico, additional, Naessens, Daphne M. P., additional, Nava-Gomez, Laura J., additional, Nonaka, Hiroi, additional, Ortiz, Juan J., additional, Paasonen, Jaakko, additional, Peeters, Lore M., additional, Pereira, Mickaël, additional, Perez, Pablo D., additional, Pompilus, Marjory, additional, Prior, Malcolm, additional, Rakhmatullin, Rustam, additional, Reimann, Henning M., additional, Reinwald, Jonathan, additional, Del Rio, Rodrigo Triana, additional, Rivera-Olvera, Alejandro, additional, Ruiz-Pérez, Daniel, additional, Russo, Gabriele, additional, Rutten, Tobias J., additional, Ryoke, Rie, additional, Sack, Markus, additional, Salvan, Piergiorgio, additional, Sanganahalli, Basavaraju G., additional, Schroeter, Aileen, additional, Seewoo, Bhedita J., additional, Selingue, Erwan, additional, Seuwen, Aline, additional, Shi, Bowen, additional, Sirmpilatze, Nikoloz, additional, Smith, Joanna A. B., additional, Smith, Corrie, additional, Sobczak, Filip, additional, Stenroos, Petteri J., additional, Straathof, Milou, additional, Strobelt, Sandra, additional, Sumiyoshi, Akira, additional, Takahashi, Kengo, additional, Torres-García, Maria E., additional, Tudela, Raul, additional, van den Berg, Monica, additional, van der Marel, Kajo, additional, van Hout, Aran T. B., additional, Vertullo, Roberta, additional, Vidal, Benjamin, additional, Vrooman, Roël M., additional, Wang, Victora X., additional, Wank, Isabel, additional, Watson, David J. G., additional, Yin, Ting, additional, Zhang, Yongzhi, additional, Zurbruegg, Stefan, additional, Achard, Sophie, additional, Alcauter, Sarael, additional, Auer, Dorothee P., additional, Barbier, Emmanuel L., additional, Baudewig, Jürgen, additional, Beckmann, Christian F., additional, Beckmann, Nicolau, additional, Becq, Guillaume J. P. C., additional, Blezer, Erwin L. A., additional, Bolbos, Radu, additional, Boretius, Susann, additional, Bouvard, Sandrine, additional, Budinger, Eike, additional, Buxbaum, Joseph D., additional, Cash, Diana, additional, Chapman, Victoria, additional, Chuang, Kai-Hsiang, additional, Ciobanu, Luisa, additional, Coolen, Bram F., additional, Dalley, Jeffrey W., additional, Dhenain, Marc, additional, Dijkhuizen, Rick M., additional, Esteban, Oscar, additional, Faber, Cornelius, additional, Febo, Marcelo, additional, Feindel, Kirk W., additional, Forloni, Gianluigi, additional, Fouquet, Jérémie, additional, Garza-Villarreal, Eduardo A., additional, Gass, Natalia, additional, Glennon, Jeffrey C., additional, Gozzi, Alessandro, additional, Gröhn, Olli, additional, Harkin, Andrew, additional, Heerschap, Arend, additional, Helluy, Xavier, additional, Herfert, Kristina, additional, Heuser, Arnd, additional, Homberg, Judith R., additional, Houwing, Danielle J., additional, Hyder, Fahmeed, additional, Ielacqua, Giovanna Diletta, additional, Jelescu, Ileana O., additional, Johansen-Berg, Heidi, additional, Kaneko, Gen, additional, Kawashima, Ryuta, additional, Keilholz, Shella D., additional, Keliris, Georgios A., additional, Kelly, Clare, additional, Kerskens, Christian, additional, Khokhar, Jibran Y., additional, Kind, Peter C., additional, Langlois, Jean-Baptiste, additional, Lerch, Jason P., additional, López-Hidalgo, Monica A., additional, Manahan-Vaughan, Denise, additional, Marchand, Fabien, additional, Mars, Rogier B., additional, Marsella, Gerardo, additional, Micotti, Edoardo, additional, Muñoz-Moreno, Emma, additional, Near, Jamie, additional, Niendorf, Thoralf, additional, Otte, Willem M., additional, Pais-Roldán, Patricia, additional, Pan, Wen-Ju, additional, Prado-Alcalá, Roberto A., additional, Quirarte, Gina L., additional, Rodger, Jennifer, additional, Rosenow, Tim, additional, Sampaio-Baptista, Cassandra, additional, Sartorius, Alexander, additional, Sawiak, Stephen J., additional, Scheenen, Tom W. J., additional, Shemesh, Noam, additional, Shih, Yen-Yu Ian, additional, Shmuel, Amir, additional, Soria, Guadalupe, additional, Stoop, Ron, additional, Thompson, Garth J., additional, Till, Sally M., additional, Todd, Nick, additional, Van Der Linden, Annemie, additional, van der Toorn, Annette, additional, van Tilborg, Geralda A. F., additional, Vanhove, Christian, additional, Veltien, Andor, additional, Verhoye, Marleen, additional, Wachsmuth, Lydia, additional, Weber-Fahr, Wolfgang, additional, Wenk, Patricia, additional, Yu, Xin, additional, Zerbi, Valerio, additional, Zhang, Nanyin, additional, Zhang, Baogui B., additional, Zimmer, Luc, additional, Devenyi, Gabriel A., additional, Chakravarty, M. Mallar, additional, and Hess, Andreas, additional

Published
2023
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12. Author Correction: A consensus protocol for functional connectivity analysis in the rat brain (Nature Neuroscience, (2023), 26, 4, (673-681), 10.1038/s41593-023-01286-8)

Author

In Vivo NMR ISI, Trialbureau Beeld, Brain, Circulatory Health, Stroke, Hubrecht Institute with UMC, Projectafdeling KIND, Grandjean, Joanes, Desrosiers-Gregoire, Gabriel, Anckaerts, Cynthia, Angeles-Valdez, Diego, Ayad, Fadi, Barrière, David A., Blockx, Ines, Bortel, Aleksandra, Broadwater, Margaret, Cardoso, Beatriz M., Célestine, Marina, Chavez-Negrete, Jorge E., Choi, Sangcheon, Christiaen, Emma, Clavijo, Perrin, Colon-Perez, Luis, Cramer, Samuel, Daniele, Tolomeo, Dempsey, Elaine, Diao, Yujian, Doelemeyer, Arno, Dopfel, David, Dvořáková, Lenka, Falfán-Melgoza, Claudia, Fernandes, Francisca F., Fowler, Caitlin F., Fuentes-Ibañez, Antonio, Garin, Clément M., Gelderman, Eveline, Golden, Carla E.M., Guo, Chao C.G., Henckens, Marloes J.A.G., Hennessy, Lauren A., Herman, Peter, Hofwijks, Nita, Horien, Corey, Ionescu, Tudor M., Jones, Jolyon, Kaesser, Johannes, Kim, Eugene, Lambers, Henriette, Lazari, Alberto, Lee, Sung Ho, Lillywhite, Amanda, Liu, Yikang, Liu, Yanyan Y., López -Castro, Alejandra, López-Gil, Xavier, Ma, Zilu, MacNicol, Eilidh, Madularu, Dan, Mandino, Francesca, Marciano, Sabina, McAuslan, Matthew J., McCunn, Patrick, McIntosh, Alison, Meng, Xianzong, Meyer-Baese, Lisa, Missault, Stephan, Moro, Federico, Naessens, Daphne M.P., Nava-Gomez, Laura J., Nonaka, Hiroi, Ortiz, Juan J., Paasonen, Jaakko, Peeters, Lore M., Pereira, Mickaël, Perez, Pablo D., Pompilus, Marjory, Prior, Malcolm, Rakhmatullin, Rustam, Reimann, Henning M., Reinwald, Jonathan, Del Rio, Rodrigo Triana, Rivera-Olvera, Alejandro, Ruiz-Pérez, Daniel, Russo, Gabriele, Rutten, Tobias J., Ryoke, Rie, Sack, Markus, Salvan, Piergiorgio, Sanganahalli, Basavaraju G., Schroeter, Aileen, Seewoo, Bhedita J., Selingue, Erwan, Seuwen, Aline, Shi, Bowen, Sirmpilatze, Nikoloz, Smith, Joanna A.B., Smith, Corrie, Sobczak, Filip, Stenroos, Petteri J., Straathof, Milou, Strobelt, Sandra, Sumiyoshi, Akira, Takahashi, Kengo, Torres-García, Maria E., Tudela, Raul, van den Berg, Monica, van der Marel, Kajo, van Hout, Aran T.B., Vertullo, Roberta, Vidal, Benjamin, Vrooman, Roël M., Wang, Victora X., Wank, Isabel, Watson, David J.G., Yin, Ting, Zhang, Yongzhi, Zurbruegg, Stefan, Achard, Sophie, Alcauter, Sarael, Auer, Dorothee P., Barbier, Emmanuel L., Baudewig, Jürgen, Beckmann, Christian F., Beckmann, Nicolau, Becq, Guillaume J.P.C., Blezer, Erwin L.A., Bolbos, Radu, Boretius, Susann, Bouvard, Sandrine, Budinger, Eike, Buxbaum, Joseph D., Cash, Diana, Chapman, Victoria, Chuang, Kai Hsiang, Ciobanu, Luisa, Coolen, Bram F., Dalley, Jeffrey W., Dhenain, Marc, Dijkhuizen, Rick M., Esteban, Oscar, Faber, Cornelius, Febo, Marcelo, Feindel, Kirk W., Forloni, Gianluigi, Fouquet, Jérémie, Garza-Villarreal, Eduardo A., Gass, Natalia, Glennon, Jeffrey C., Gozzi, Alessandro, Gröhn, Olli, Harkin, Andrew, Heerschap, Arend, Helluy, Xavier, Herfert, Kristina, Heuser, Arnd, Homberg, Judith R., Houwing, Danielle J., Hyder, Fahmeed, Ielacqua, Giovanna Diletta, Jelescu, Ileana O., Johansen-Berg, Heidi, Kaneko, Gen, Kawashima, Ryuta, Keilholz, Shella D., Keliris, Georgios A., Kelly, Clare, Kerskens, Christian, Khokhar, Jibran Y., Kind, Peter C., Langlois, Jean Baptiste, Lerch, Jason P., López-Hidalgo, Monica A., Manahan-Vaughan, Denise, Marchand, Fabien, Mars, Rogier B., Marsella, Gerardo, Micotti, Edoardo, Muñoz-Moreno, Emma, Near, Jamie, Niendorf, Thoralf, Otte, Willem M., Pais-Roldán, Patricia, Pan, Wen Ju, Prado-Alcalá, Roberto A., Quirarte, Gina L., Rodger, Jennifer, Rosenow, Tim, Sampaio-Baptista, Cassandra, Sartorius, Alexander, Sawiak, Stephen J., Scheenen, Tom W.J., Shemesh, Noam, Shih, Yen Yu Ian, Shmuel, Amir, Soria, Guadalupe, Stoop, Ron, Thompson, Garth J., Till, Sally M., Todd, Nick, Van Der Linden, Annemie, van der Toorn, Annette, van Tilborg, Geralda A.F., Vanhove, Christian, Veltien, Andor, Verhoye, Marleen, Wachsmuth, Lydia, Weber-Fahr, Wolfgang, Wenk, Patricia, Yu, Xin, Zerbi, Valerio, Zhang, Nanyin, Zhang, Baogui B., Zimmer, Luc, Devenyi, Gabriel A., Chakravarty, M. Mallar, Hess, Andreas, In Vivo NMR ISI, Trialbureau Beeld, Brain, Circulatory Health, Stroke, Hubrecht Institute with UMC, Projectafdeling KIND, Grandjean, Joanes, Desrosiers-Gregoire, Gabriel, Anckaerts, Cynthia, Angeles-Valdez, Diego, Ayad, Fadi, Barrière, David A., Blockx, Ines, Bortel, Aleksandra, Broadwater, Margaret, Cardoso, Beatriz M., Célestine, Marina, Chavez-Negrete, Jorge E., Choi, Sangcheon, Christiaen, Emma, Clavijo, Perrin, Colon-Perez, Luis, Cramer, Samuel, Daniele, Tolomeo, Dempsey, Elaine, Diao, Yujian, Doelemeyer, Arno, Dopfel, David, Dvořáková, Lenka, Falfán-Melgoza, Claudia, Fernandes, Francisca F., Fowler, Caitlin F., Fuentes-Ibañez, Antonio, Garin, Clément M., Gelderman, Eveline, Golden, Carla E.M., Guo, Chao C.G., Henckens, Marloes J.A.G., Hennessy, Lauren A., Herman, Peter, Hofwijks, Nita, Horien, Corey, Ionescu, Tudor M., Jones, Jolyon, Kaesser, Johannes, Kim, Eugene, Lambers, Henriette, Lazari, Alberto, Lee, Sung Ho, Lillywhite, Amanda, Liu, Yikang, Liu, Yanyan Y., López -Castro, Alejandra, López-Gil, Xavier, Ma, Zilu, MacNicol, Eilidh, Madularu, Dan, Mandino, Francesca, Marciano, Sabina, McAuslan, Matthew J., McCunn, Patrick, McIntosh, Alison, Meng, Xianzong, Meyer-Baese, Lisa, Missault, Stephan, Moro, Federico, Naessens, Daphne M.P., Nava-Gomez, Laura J., Nonaka, Hiroi, Ortiz, Juan J., Paasonen, Jaakko, Peeters, Lore M., Pereira, Mickaël, Perez, Pablo D., Pompilus, Marjory, Prior, Malcolm, Rakhmatullin, Rustam, Reimann, Henning M., Reinwald, Jonathan, Del Rio, Rodrigo Triana, Rivera-Olvera, Alejandro, Ruiz-Pérez, Daniel, Russo, Gabriele, Rutten, Tobias J., Ryoke, Rie, Sack, Markus, Salvan, Piergiorgio, Sanganahalli, Basavaraju G., Schroeter, Aileen, Seewoo, Bhedita J., Selingue, Erwan, Seuwen, Aline, Shi, Bowen, Sirmpilatze, Nikoloz, Smith, Joanna A.B., Smith, Corrie, Sobczak, Filip, Stenroos, Petteri J., Straathof, Milou, Strobelt, Sandra, Sumiyoshi, Akira, Takahashi, Kengo, Torres-García, Maria E., Tudela, Raul, van den Berg, Monica, van der Marel, Kajo, van Hout, Aran T.B., Vertullo, Roberta, Vidal, Benjamin, Vrooman, Roël M., Wang, Victora X., Wank, Isabel, Watson, David J.G., Yin, Ting, Zhang, Yongzhi, Zurbruegg, Stefan, Achard, Sophie, Alcauter, Sarael, Auer, Dorothee P., Barbier, Emmanuel L., Baudewig, Jürgen, Beckmann, Christian F., Beckmann, Nicolau, Becq, Guillaume J.P.C., Blezer, Erwin L.A., Bolbos, Radu, Boretius, Susann, Bouvard, Sandrine, Budinger, Eike, Buxbaum, Joseph D., Cash, Diana, Chapman, Victoria, Chuang, Kai Hsiang, Ciobanu, Luisa, Coolen, Bram F., Dalley, Jeffrey W., Dhenain, Marc, Dijkhuizen, Rick M., Esteban, Oscar, Faber, Cornelius, Febo, Marcelo, Feindel, Kirk W., Forloni, Gianluigi, Fouquet, Jérémie, Garza-Villarreal, Eduardo A., Gass, Natalia, Glennon, Jeffrey C., Gozzi, Alessandro, Gröhn, Olli, Harkin, Andrew, Heerschap, Arend, Helluy, Xavier, Herfert, Kristina, Heuser, Arnd, Homberg, Judith R., Houwing, Danielle J., Hyder, Fahmeed, Ielacqua, Giovanna Diletta, Jelescu, Ileana O., Johansen-Berg, Heidi, Kaneko, Gen, Kawashima, Ryuta, Keilholz, Shella D., Keliris, Georgios A., Kelly, Clare, Kerskens, Christian, Khokhar, Jibran Y., Kind, Peter C., Langlois, Jean Baptiste, Lerch, Jason P., López-Hidalgo, Monica A., Manahan-Vaughan, Denise, Marchand, Fabien, Mars, Rogier B., Marsella, Gerardo, Micotti, Edoardo, Muñoz-Moreno, Emma, Near, Jamie, Niendorf, Thoralf, Otte, Willem M., Pais-Roldán, Patricia, Pan, Wen Ju, Prado-Alcalá, Roberto A., Quirarte, Gina L., Rodger, Jennifer, Rosenow, Tim, Sampaio-Baptista, Cassandra, Sartorius, Alexander, Sawiak, Stephen J., Scheenen, Tom W.J., Shemesh, Noam, Shih, Yen Yu Ian, Shmuel, Amir, Soria, Guadalupe, Stoop, Ron, Thompson, Garth J., Till, Sally M., Todd, Nick, Van Der Linden, Annemie, van der Toorn, Annette, van Tilborg, Geralda A.F., Vanhove, Christian, Veltien, Andor, Verhoye, Marleen, Wachsmuth, Lydia, Weber-Fahr, Wolfgang, Wenk, Patricia, Yu, Xin, Zerbi, Valerio, Zhang, Nanyin, Zhang, Baogui B., Zimmer, Luc, Devenyi, Gabriel A., Chakravarty, M. Mallar, and Hess, Andreas

Published
2023

14. PREMISE: A database of 20Macaca FascicularisPET/MRI brain imaging available for research

Author

Chalet, Lucie, primary, Debatisse, Justine, additional, Wateau, Oceane, additional, Boutelier, Timothe, additional, Wiart, Marlène, additional, Costes, Nicolas, additional, Merida, Ines, additional, Redouté, Jérôme, additional, Langlois, Jean-Baptiste, additional, Lancelot, Sophie, additional, Léon, Christelle, additional, Cho, Tae-Hee, additional, Mechtouff, Laura, additional, Eker, Omer Faruk, additional, Nighoghossian, Norbert, additional, Canet-Soulas, Emmanuelle, additional, and Becker, Guillaume, additional

Published
2023
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17. StandardRat: A multi-center consensus protocol to enhance functional connectivity specificity in the rat brain

Author

Grandjean, Joanes, primary, Desrosiers-Gregoire, Gabriel, additional, Anckaerts, Cynthia, additional, Angeles-Valdez, Diego, additional, Ayad, Fadi, additional, Barrière, David A, additional, Blockx, Ines, additional, Bortel, Aleksandra B, additional, Broadwater, Margaret, additional, Cardoso, Beatriz M, additional, Célestine, Marina, additional, Chavez-Negrete, Jorge E, additional, Choi, Sangcheon, additional, Christiaen, Emma, additional, Clavijo, Perrin, additional, Colon-Perez, Luis, additional, Cramer, Samuel, additional, Daniele, Tolomeo, additional, Dempsey, Elaine, additional, Diao, Yujian, additional, Doelemeyer, Arno, additional, Dopfel, David, additional, Dvořáková, Lenka, additional, Falfán-Melgoza, Claudia, additional, Fernandes, Francisca F, additional, Fowler, Caitlin F, additional, Fuentes-Ibañez, Antonio, additional, Garin, Clément, additional, Gelderman, Eveline, additional, Golden, Carla EM, additional, Guo, Chao CG, additional, Henckens, Marloes JAG, additional, Hennessy, Lauren A, additional, Herman, Peter, additional, Hofwijks, Nita, additional, Horien, Corey, additional, Ionescu, Tudor M, additional, Jones, Jolyon, additional, Kaesser, Johannes, additional, Kim, Eugene, additional, Lambers, Henriette, additional, Lazari, Alberto, additional, Lee, Sung-Ho, additional, Lillywhite, Amanda, additional, Liu, Yikang, additional, Liu, Yanyan Y, additional, López-Castro, Alejandra, additional, López-Gil, Xavier, additional, Ma, Zilu, additional, MacNicol, Eilidh, additional, Madularu, Dan, additional, Mandino, Francesca, additional, Marciano, Sabina, additional, McAuslan, Matthew J, additional, McCunn, Patrick, additional, McIntosh, Alison, additional, Meng, Xianzong, additional, Meyer-Baese, Lisa, additional, Missault, Stephan, additional, Moro, Federico, additional, Naessens, Daphne, additional, Nava-Gomez, Laura J, additional, Nonaka, Hiroi, additional, Ortiz, Juan J, additional, Paasonen, Jaakko, additional, Peeters, Lore M, additional, Pereira, Mickaël, additional, Perez, Pablo D, additional, Pompilus, Marjory, additional, Prior, Malcolm, additional, Rakhmatullin, Rustam, additional, Reimann, Henning M, additional, Reinwald, Jonathan, additional, de Rio, Rodrigo Triana, additional, Rivera-Olvera, Alejandro, additional, Ruiz-Pérez, Daniel, additional, Russo, Gabriele, additional, Rutten, Tobias J, additional, Ryoke, Rie, additional, Sack, Markus, additional, Salvan, Piergiorgio, additional, Sanganahalli, Basavaraju G, additional, Schroeter, Aileen, additional, Seewoo, Bhedita J, additional, Selingue, Erwan, additional, Seuwen, Aline, additional, Shi, Bowen, additional, Sirmpilatze, Nikoloz, additional, Smith, Joanna AB, additional, Smith, Corrie, additional, Sobczak, Filip, additional, Stenroos, Petteri J, additional, Straathof, Milou, additional, Strobelt, Sandra, additional, Sumiyoshi, Akira, additional, Takahashi, Kengo, additional, Torres-García, Maria E, additional, Tudela, Raul, additional, van den Berg, Monica, additional, van der Marel, Kajo, additional, van Hout, Aran TB, additional, Vertullo, Roberta, additional, Vidal, Benjamin, additional, Vrooman, Roel M, additional, Wang, Victora X, additional, Wank, Isabel, additional, Watson, David JG, additional, Yin, Ting, additional, Zhang, Yongzhi, additional, Zurbruegg, Stefan, additional, Achard, Sophie, additional, Alcauter, Sarael, additional, Auer, Dorothee P, additional, Barbier, Emmanuel L, additional, Baudewig, Jürgen, additional, Beckmann, Christian F, additional, Beckmann, Nicolau, additional, Becq, Guillaume JPC, additional, Blezer, Erwin LA, additional, Bolbos, Radu, additional, Boretius, Susann, additional, Bouvard, Sandrine, additional, Budinger, Eike, additional, Buxbaum, Joseph D, additional, Cash, Diana, additional, Chapman, Victoria, additional, Chuang, Kai-Hsiang, additional, Ciobanu, Luisa, additional, Coolen, Bram, additional, Dalley, Jeffrey W, additional, Dhenain, Marc, additional, Dijkhuizen, Rick M, additional, Esteban, Oscar, additional, Faber, Cornelius, additional, Febo, Marcelo, additional, Feindel, Kirk W, additional, Forloni, Gianluigi, additional, Fouquet, Jérémie, additional, Garza-Villarreal, Eduardo A, additional, Gass, Natalia, additional, Glennon, Jeffrey C, additional, Gozzi, Alessandro, additional, Gröhn, Olli, additional, Harkin, Andrew, additional, Heerschap, Arend, additional, Helluy, Xavier, additional, Herfert, Kristina, additional, Heuser, Arnd, additional, Homberg, Judith R, additional, Houwing, Danielle J, additional, Hyder, Fahmeed, additional, Ielacqua, Giovanna Diletta, additional, Jelescu, Ileana O, additional, Johansen-Berg, Heidi, additional, Kaneko, Gen, additional, Kawashima, Ryuta, additional, Keilholz, Shella D, additional, Keliris, Georgios A, additional, Kelly, Clare, additional, Kerskens, Christian, additional, Khokhar, Jibran Y, additional, Kind, Peter C, additional, Langlois, Jean-Baptiste, additional, Lerch, Jason P, additional, López-Hidalgo, Monica A, additional, Manahan-Vaughan, Denise, additional, Marchand, Fabien, additional, Mars, Rogier B, additional, Marsella, Gerardo, additional, Micotti, Edoardo, additional, Muñoz-Moreno, Emma, additional, Near, Jamie, additional, Niendorf, Thoralf, additional, Otte, Willem M, additional, Pais, Patricia, additional, Pan, Wen-Ju, additional, Prado-Alcalá, Roberto A, additional, Quirarte, Gina L, additional, Rodger, Jennifer, additional, Rosenow, Tim, additional, Baptista, Cassandra Sampaio, additional, Sartorius, Alexander, additional, Sawiak, Stephen J, additional, Scheenen, Tom WJ, additional, Shemesh, Noam, additional, Shih, Yen-Yu Ian, additional, Shmuel, Amir, additional, Soria, Guadalupe, additional, Stoop, Ron, additional, Thompson, Garth J, additional, Till, Sally M, additional, Todd, Nick, additional, Van Der Linden, Annemie, additional, van der Toorn, Annette, additional, van Tilborg, Geralda AF, additional, Vanhove, Christian, additional, Veltien, Andor, additional, Verhoye, Marleen, additional, Wachsmuth, Lydia, additional, Weber-Fahr, Wolfgang, additional, Wenk, Patricia, additional, Yu, Xin, additional, Zerbi, Valerio, additional, Zhang, Nanyin, additional, Zhang, Baogui B, additional, Zimmer, Luc, additional, Devenyi, Gabriel A, additional, Chakravarty, M Mallar, additional, and Hess, Andreas, additional

Published
2022
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22. Stabilizing Inactive Conformations of MALT1 as an Effective Approach to Inhibit Its Protease Activity

Author

Hughes, Nicola, primary, Erbel, Paul, additional, Bornancin, Frédéric, additional, Wiesmann, Christian, additional, Schiering, Nikolaus, additional, Villard, Frédéric, additional, Decock, Arnaud, additional, Rubi, Bertran, additional, Melkko, Samu, additional, Spanka, Carsten, additional, Buschmann, Nicole, additional, Pissot‐Soldermann, Carole, additional, Simic, Oliver, additional, Beerli, René, additional, Sorge, Mickael, additional, Tintelnot‐Blomley, Marina, additional, Beltz, Karen, additional, Régnier, Catherine H., additional, Quancard, Jean, additional, Schlapbach, Achim, additional, Langlois, Jean‐Baptiste, additional, and Renatus, Martin, additional

Published
2020
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23. A non-human primate model of stroke reproducing endovascular thrombectomy and allowing long-term imaging and neurological read-outs

Author

Debatisse, Justine, primary, Wateau, Océane, additional, Cho, Tae-Hee, additional, Costes, Nicolas, additional, Mérida, Inés, additional, Léon, Christelle, additional, Langlois, Jean-Baptiste, additional, Taborik, Fabrice, additional, Verset, Michaël, additional, Portier, Karine, additional, Aggour, Mohamed, additional, Troalen, Thomas, additional, Villien, Marjorie, additional, Makris, Nikolaos, additional, Tourvieille, Christian, additional, Bars, Didier Le, additional, Lancelot, Sophie, additional, Confais, Joachim, additional, Oudotte, Adrien, additional, Nighoghossian, Norbert, additional, Ovize, Michel, additional, Vivien, Denis, additional, Contamin, Hugues, additional, Agin, Véronique, additional, Canet-Soulas, Emmanuelle, additional, and Eker, Omer Faruk, additional

Published
2020
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24. PET-MRI nanoparticles imaging of blood–brain barrier damage and modulation after stroke reperfusion

Author

Debatisse, Justine, primary, Eker, Omer Faruk, additional, Wateau, Océane, additional, Cho, Tae-Hee, additional, Wiart, Marlène, additional, Ramonet, David, additional, Costes, Nicolas, additional, Mérida, Inés, additional, Léon, Christelle, additional, Dia, Maya, additional, Paillard, Mélanie, additional, Confais, Joachim, additional, Rossetti, Fabien, additional, Langlois, Jean-Baptiste, additional, Troalen, Thomas, additional, Iecker, Thibaut, additional, Le Bars, Didier, additional, Lancelot, Sophie, additional, Bouchier, Baptiste, additional, Lukasziewicz, Anne-Claire, additional, Oudotte, Adrien, additional, Nighoghossian, Norbert, additional, Ovize, Michel, additional, Contamin, Hugues, additional, Lux, François, additional, Tillement, Olivier, additional, and Canet-Soulas, Emmanuelle, additional

Published
2020
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26. Stabilizing Inactive Conformations of MALT1 as an Effective Approach to Inhibit Its Protease Activity

Author

Arnaud Decock, Paul Erbel, Mickael Sorge, Rene Beerli, Samu Melkko, Frédéric Bornancin, Bertran Rubi, Oliver Simic, Catherine H. Régnier, Carole Pissot-Soldermann, Martin Renatus, Jean Quancard, Achim Schlapbach, Langlois Jean Baptiste Georges Armand, Nikolaus Schiering, Nicola Hughes, Marina Tintelnot-Blomley, Karen Beltz, Frederic Villard, Nicole Buschmann, Carsten Spanka, and Christian Wiesmann

Subjects
Pharmacology, Protease, Stereochemistry, Chemistry, Drug discovery, medicine.medical_treatment, Biochemistry (medical), Allosteric regulation, Pharmaceutical Science, Medicine (miscellaneous), MALT1, medicine, Pharmacology (medical), Genetics (clinical)
Published
2020
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27. Feasibility of improving vascular imaging in the presence of metallic stents using spectral photon counting CT and K-edge imaging

Author

Sigovan, Monica, primary, Si-Mohamed, Salim, additional, Bar-Ness, Daniel, additional, Mitchell, Julia, additional, Langlois, Jean-Baptiste, additional, Coulon, Philippe, additional, Roessl, Ewald, additional, Blevis, Ira, additional, Rokni, Michal, additional, Rioufol, Gilles, additional, Douek, Philippe, additional, and Boussel, Loic, additional

Published
2019
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28. A Conformational Restriction Strategy for the Identification of a Highly Selective Pyrimido-pyrrolo-oxazine mTOR Inhibitor

Author

Borsari, Chiara, primary, Rageot, Denise, additional, Dall’Asen, Alix, additional, Bohnacker, Thomas, additional, Melone, Anna, additional, Sele, Alexander M., additional, Jackson, Eileen, additional, Langlois, Jean-Baptiste, additional, Beaufils, Florent, additional, Hebeisen, Paul, additional, Fabbro, Doriano, additional, Hillmann, Petra, additional, and Wymann, Matthias P., additional

Published
2019
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30. A non-human primate model of stroke reproducing endovascular thrombectomy and allowing long-term imaging and neurological read-outs.

Author

Debatisse, Justine, Wateau, Océane, Cho, Tae-Hee, Costes, Nicolas, Mérida, Inés, Léon, Christelle, Langlois, Jean-Baptiste, Taborik, Fabrice, Verset, Michaël, Portier, Karine, Aggour, Mohamed, Troalen, Thomas, Villien, Marjorie, Makris, Nikolaos, Tourvieille, Christian, Bars, Didier Le, Lancelot, Sophie, Confais, Joachim, Oudotte, Adrien, and Nighoghossian, Norbert

Abstract

Stroke is a devastating disease. Endovascular mechanical thrombectomy is dramatically changing the management of acute ischemic stroke, raising new challenges regarding brain outcome and opening up new avenues for brain protection. In this context, relevant experiment models are required for testing new therapies and addressing important questions about infarct progression despite successful recanalization, reversibility of ischemic lesions, blood–brain barrier disruption and reperfusion damage. Here, we developed a minimally invasive non-human primate model of cerebral ischemia (Macaca fascicularis) based on an endovascular transient occlusion and recanalization of the middle cerebral artery (MCA). We evaluated per-occlusion and post-recanalization impairment on PET-MRI, in addition to acute and chronic neuro-functional assessment. Voxel-based analyses between per-occlusion PET-MRI and day-7 MRI showed two different patterns of lesion evolution: "symptomatic salvaged tissue" (SST) and "asymptomatic infarcted tissue" (AIT). Extended SST was present in all cases. AIT, remote from the area at risk, represented 45% of the final lesion. This model also expresses both worsening of fine motor skills and dysexecutive behavior over the chronic post-stroke period, a result in agreement with cortical-subcortical lesions. We thus fully characterized an original translational model of ischemia–reperfusion damage after stroke, with consistent ischemia time, and thrombus retrieval for effective recanalization. [ABSTRACT FROM AUTHOR]

Published
2021
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31. A Fungal-Selective Cytochrome bc₁ Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance

Author

Srinivas, Raja, Lancaster, Alex K., Scherz-Shouval, Ruth, Whitesell, Luke, Vincent, Benjamin Matteson, Langlois, Jean-Baptiste, Tidor, Bruce, Buchwald, Stephen Leffler, Lindquist, Susan, Massachusetts Institute of Technology. Department of Biological Engineering, Massachusetts Institute of Technology. Department of Biology, Massachusetts Institute of Technology. Department of Chemistry, Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Vincent, Benjamin Matteson, Langlois, Jean-Baptiste, Tidor, Bruce, Buchwald, Stephen Leffler, and Lindquist, Susan

Abstract

To cause disease, a microbial pathogen must adapt to the challenges of its host environment. The leading fungal pathogen Candida albicans colonizes nutrient-poor bodily niches, withstands attack from the immune system, and tolerates treatment with azole antifungals, often evolving resistance. To discover agents that block these adaptive strategies, we screened 300,000 compounds for inhibition of azole tolerance in a drug-resistant Candida isolate. We identified a novel indazole derivative that converts azoles from fungistatic to fungicidal drugs by selective inhibition of mitochondrial cytochrome bc1. We synthesized 103 analogs to optimize potency (half maximal inhibitory concentration 0.4 μM) and fungal selectivity (28-fold over human). In addition to reducing azole resistance, targeting cytochrome bc₁ prevents C. albicans from adapting to the nutrient-deprived macrophage phagosome and greatly curtails its virulence in mice. Inhibiting mitochondrial respiration and restricting metabolic flexibility with this synthetically tractable chemotype provides an attractive therapeutic strategy to limit both fungal virulence and drug resistance., National Institutes of Health (U.S.) (GM46059)

Published
2016

32. SNR and volume characterization of RF coils: A simple procedure and an automatic post-processing tool for a straightforward comparison

Author

Mahieu-Williame, Laurent, Gaillard, Sophie, Grenier, Denis, Bolbos, Radu, Langlois, Jean-Baptiste, Lamberton, Franck, Camarasu-Pop, Sorina, Beuf, Olivier, Plateforme d'Imagerie Multimodale LyonTech (PILoT), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), RMN et optique : De la mesure au biomarqueur, Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant (CERMEP - imagerie du vivant), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Service Informatique et développements, and Images et Modèles

Subjects
[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging
Abstract

International audience; To choose the most suitable RF coil available for an MRI study, we propose a procedure which uses a calibrated phantom, a 3D gradient-echo sequence, and an automatic post-processing tool available on the web. This tool generates a report which contains the measurement of a SNR with uniform volumes located in the depth. The post-processing could be done on MR images acquired on most main MRI vendors (Siemens, GE, Philips and Bruker) with prior verification of applied scaling or filtering. RF coil characterization results performed on at 4.7T and 7T were compared. The tool can be used for quality control.

Published
2017

33. Protocole de caractérisation d'antenne radiofréquence pour l'IRM

Author

Mahieu-Williame, Laurent, Gaillard, Sophie, Grenier, Denis, Bolbos, Radu, Langlois, Jean-Baptiste, Lamberton, Franck, Camarasu-Pop, Sorina, Beuf, Olivier, Plateforme d'Imagerie Multimodale LyonTech (PILoT), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), RMN et optique : De la mesure au biomarqueur, Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant (CERMEP - imagerie du vivant), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Service Informatique et développements, Images et Modèles, Centre de recherche en neurosciences de Lyon (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Rayet, Béatrice

Subjects
Méthodes et systèmes en IRM et optique, [PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics], [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, categₛt2i, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, reseauₙational, ComputingMilieux_MISCELLANEOUS, Labex PRIMES
Abstract

National audience; But de l'étudeLes antennes radiofréquences jouent un rôle crucial dans la détection du signal IRM. Elles connaissent une évolution permanente pour augmenter leur efficacité. Aujourd'hui, il existe un grand nombre d'antennes différentes et il peut être difficile de choisir celle qui est la plus adaptée à un examen inhabituel. De plus, ce choix peut lourdement se complexifier lorsqu'on a accès à des systèmes IRM de différents fabricants et opérant à différents champs statiques. Le protocole de caractérisation que nous proposons ici a pour but de comparer les antennes en terme de SNR et de volume uniforme. Il peut être utilisé pour comparer des systèmes IRM dans le cadre d’étude multicentrique ou encore comme outil de contrôle qualité.Matériels et MéthodeLe protocole peut se décomposer en trois étapes:1- Utiliser un fantôme chargé pour reproduire les conditions in-vivo. Dans le cadre multicentrique, la plateforme PILoT propose différents fantômes pour le clinique et le préclinique (pilot@creatis.insa-lyon.fr ).2- Acquérir les images RMN en utilisant une séquence écho de gradient 3D disponible sur tous les systèmes. 3-Traiter les acquisitions de manière automatique en utilisant notre programme déployé sur la plateforme d'imagerie virtuelle (VIP) [1] : https://vip.creatis.insa-lyon.fr et disponible en libre accès. Le programme génère un rapport au format PDF qui inclut: une mesure du SNR; des représentations de volumes uniformes à 10, 50 et 90% de variation; un tableau comparatif de toutes les antennes analysées ainsi qu'une figure des profils d'intensité superposés. Un effort particulier a été fourni pour s'assurer de la mesure du SNR en appliquant deux tests basés sur la loi de distribution du bruit dans l'air des images enmagnitude [2]. Enfin nous proposons un SNR corrigé (SNRc) prenant en compte des variations des paramètres d'acquisition ainsi que des temps de relaxation [3].RésultatsLa figure 1 montre la superposition des profils d'intensité de l'ensemble des antennes disponibles sur un IRM Bruker précliniques à 4.7T. Le fantôme utilisé simule l'abdomen d'une souris de taille moyenne. L'intersection des courbes donne une information sur la profondeur d’exploration relative par rapport aux autres antennes. Le tableau 1 présente une partie des résultats obtenus précédemment et comparés à ceux d'un IRM Bruker précliniques à 7T pour des antennes similaires. La bobine en quadrature nommée "Quadrature" provenant du même constructeur donne un rapport des SNR proche de la théorie (R = 1.5). Ce qui n'est pas le cas pour des antennes de constructeurs différents: "Loop_rat" (capteurs de configurations différentes) et "BirdCage" (bobines de générations différentes).DiscussionLa comparaison des caractéristiques mesurées par rapport à la région d’intérêt à explorer permet de choisir l'antenne avec le SNRc le plus élevé. Ainsi, on confirme par exemple dans le cas d’un examen du foie que le capteur "Loop1H_rat" est adapté à une mesure de spectroscopie localisée tandis que la bobine "Quad1H_30mm" est à privilégier pour une IRM du foie entier de souris.

Published
2017

34. Discovery and Preclinical Characterization of 5-[4,6-Bis({3-oxa-8-azabicyclo[3.2.1]octan-8-yl})-1,3,5-triazin-2-yl]-4-(difluoromethyl)pyridin-2-amine (PQR620), a Highly Potent and Selective mTORC1/2 Inhibitor for Cancer and Neurological Disorders

Author

Rageot, Denise, primary, Bohnacker, Thomas, additional, Melone, Anna, additional, Langlois, Jean-Baptiste, additional, Borsari, Chiara, additional, Hillmann, Petra, additional, Sele, Alexander M., additional, Beaufils, Florent, additional, Zvelebil, Marketa, additional, Hebeisen, Paul, additional, Löscher, Wolfgang, additional, Burke, John, additional, Fabbro, Doriano, additional, and Wymann, Matthias P., additional

Published
2018
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35. Plate-forme d’imagerie préclinique AnimAge du CERMEP

Author

Bolbos, Radu, Langlois, Jean-Baptiste, Bouillot, Caroline, Gualda, Véronique, Zimmer, Luc, Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant (CERMEP - imagerie du vivant), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Centre de recherche en neurosciences de Lyon (CRNL), and Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging
Abstract

National audience; Le CERMEP (Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire) est un centre d'imagerie in vivomultimodale dédié à la recherche biomédicale fondamentale et clinique. A ce titre, le CERMEP fait partie du Noeud Lyonnais de l’infrastructure nationale France Life Imaging (FLI).La plate-forme d’imagerie préclinique ANIMAGE est un département du CERMEP qui a pour objectif de proposer aux chercheurs académiques ou industriels des méthodes d’imagerie in vivo pour l’exploration anatomique, moléculaire et fonctionnelle du petit animal de laboratoire.En termes d’équipement d’imagerie, ANIMAGE dispose d’une IRM BRUKER BioSpec 7T, d’une caméra TEP/TDM SIEMENS Inveon, d’un scanner SKYSCAN-1076 aux rayons X et d’un échographe VISUALSONICS Vevo 770. Une vingtaine de radiotraceurs TEP sont accessibles grâce à la proximité du département de radiochimie et radiopharmacie du CERMEP. Des explorations autoradiographiques in vitro de ces radiotraceurs sont également possibles sur le site. Tous les imageurs sont équipés d’anesthésie gazeuse, d’un poste de contrôle et de suivi physiologique qui servent d’outils de monitoring des animaux tout au long des expérimentations, ponctuelles ou longitudinales. Une salle de salle de chirurgie est mise à la disposition des expérimentateurs, à proximité immédiate des imageurs. Equipée de deux paillasses, disposant de postes d'anesthésie gazeuse, microscopes, etc., elle permet la préparation des modèles animaux ou des journées de formations. Une animalerie conventionnelle (type A1 avec un niveau de confinement L2) permet d'héberger les animaux pendant la durée du protocole d'imagerie. Ces locaux sont agréés par les services vétérinaires pour cinq espèces animales (porcs, lapins, chats, rats, souris). La structure « Bien-Etre Animal » interne au CERMEP accompagne les investigateurs dans leur demande d’autorisation de projet utilisant des animaux à des fins scientifiques (APAFIS – Comité d’éthique). L’essentiel des applications visées aujourd’hui se situe dans le domaine des neurosciences mais la plateforme est ouverte à d’autres thématiques (oncologie, cardiologie, métabolisme, etc.).Les membres d’ANIMAGE accompagnent les équipes de recherche tout au long du protocole de recherche, selon leurs besoins :- définition de la question biologique/physiopathologique/pharmacologique à laquelle pourra répondre l’imagerie,- adéquation de la modalité d’imagerie et du modèle expérimental,- organisation du protocole expérimental,- préparation du modèle animal,- acquisition des images in vivo,- analyse des images et aide à la valorisation scientifique (rapport, article...).

Published
2016

37. Evaluation of spectral photon counting computed tomography K-edge imaging for determination of gold nanoparticle biodistribution in vivo

Author

Si-Mohamed, Salim, primary, Cormode, David P., additional, Bar-Ness, Daniel, additional, Sigovan, Monica, additional, Naha, Pratap C., additional, Langlois, Jean-Baptiste, additional, Chalabreysse, Lara, additional, Coulon, Philippe, additional, Blevis, Ira, additional, Roessl, Ewald, additional, Erhard, Klaus, additional, Boussel, Loic, additional, and Douek, Philippe, additional

Published
2017
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38. Protocole de caractérisation et de comparaison des bobines RF applicable aux systèmes d'IRM précliniques et cliniques

Author

Gaillard, Sophie, Mahieu-Williame, Laurent, Bolbos, Radu, Langlois, Jean-Baptiste, Grenier, Denis, Beuf, Olivier, Plateforme d'Imagerie Multimodale LyonTech (PILoT), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant (CERMEP - imagerie du vivant), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), RMN et optique : De la mesure au biomarqueur, Rayet, Béatrice, Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)

Subjects
Méthodes et systèmes en IRM et optique, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, categₛt2i, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, reseauₙational, ComputingMilieux_MISCELLANEOUS, Labex PRIMES
Abstract

National audience; Le calcul théorique du profil de sensibilité et du rapport signal à bruit (SNR) des bobines RF peut se faire analytiquement [1-3] mais nécessite d'avoir une connaissance complète des caractéristiques du capteur ce qui n'est pas le cas pour les capteurs commerciaux. Le but de ce travail est de standardiser et de diffuser un protocole expérimental permettant de caractériser le SNR et le volume de sensibilité des bobines et capteurs RF adaptés à la fois aux systèmes IRM précliniques et cliniques. La première motivation est de comparer les performances des capteurs entre eux. Ce protocole peut également être utilisé pour suivre les équipements dans le cadre d'une démarche qualité.

Published
2015

39. Exercise Does Not Protect against Peripheral and Central Effects of a High Cholesterol Diet Given Ad libitum in Old ApoE−/− Mice

Author

Di Cataldo, Vanessa, primary, Géloën, Alain, additional, Langlois, Jean-Baptiste, additional, Chauveau, Fabien, additional, Thézé, Benoît, additional, Hubert, Violaine, additional, Wiart, Marlène, additional, Chirico, Erica N., additional, Rieusset, Jennifer, additional, Vidal, Hubert, additional, Pialoux, Vincent, additional, and Canet-Soulas, Emmanuelle, additional

Published
2016
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40. Tif1γ Suppresses Murine Pancreatic Tumoral Transformation by a Smad4-Independent Pathway

Author

Vincent, David F., Gout, Johann, Chuvin, Nicolas, Arfi, Vanessa, Pommier, Roxane M., Bertolino, Philippe, Jonckheere, Nicolas, Ripoche, Doriane, Kaniewski, Bastien, Martel, Sylvie, Langlois, Jean-Baptiste, Goddard-Léon, Sophie, Colombe, Amélie, Janier, Marc, Van Seuningen, Isabelle, Losson, Régine, Valcourt, Ulrich, Treilleux, Isabelle, Dubus, Pierre, Bardeesy, Nabeel, and Bartholin, Laurent

Published
2012
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41. From enantioconvergent to stereodivergent processes in copper-catalyzed asymmetric allylic alkylation

Author

Langlois, Jean-Baptiste and Alexakis, Alexandre

Subjects
Racemic substrate, ddc:540, Asymmetric catalysis, Enantioconvergent process, Copper, Allylic substitution
Abstract

The copper-catalyzed asymmetric allylic alkylation (AAA) is one of the most powerful methods to introduce a simple alkyl group in allylic position. Copper is particularly known to induce a high γ-selectivity stemming from a SN2' process. This feature has been mainly applied to the alkylation of linear prochiral substrates leading to the formation of stereogenic centers. In sharp contrast, the use of racemic substrates has been scarcely studied. We will present here that this range of substrates could be interesting reaction partners leading to the development of new valuable resolution processes.

Published
2011
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43. Telomerase inhibition improves tumor response to radiotherapy in a murine orthotopic model of human glioblastoma

Author

Ferrandon, Sylvain, primary, Malleval, Céline, additional, El Hamdani, Badia, additional, Battiston-Montagne, Priscillia, additional, Bolbos, Radu, additional, Langlois, Jean-Baptiste, additional, Manas, Patrick, additional, Gryaznov, Sergei M, additional, Alphonse, Gersende, additional, Honnorat, Jérôme, additional, Rodriguez-Lafrasse, Claire, additional, and Poncet, Delphine, additional

Published
2015
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46. Exercise Does Not Protect against Peripheral and Central Effects of a High Cholesterol Diet Given Ad libitum in Old ApoE-/- Mice.

Author

Di Cataldo, Vanessa, Géloën, Alain, Langlois, Jean-Baptiste, Chauveau, Fabien, Thézé, Benoît, Hubert, Violaine, Wiart, Marlène, Chirico, Erica N., Rieusset, Jennifer, Vidal, Hubert, Pialoux, Vincent, and Canet-Soula, Emmanuelle

Subjects
EXERCISE physiology, STRENGTH training -- Physiological aspects, HIGH cholesterol diet, HIGH-fat diet, APOLIPOPROTEIN E
Abstract

Aim: Advanced atherosclerosis increases inflammation and stroke risk in the cerebral vasculature. Exercise is known to improve cardio-metabolic profiles when associated with a caloric restriction, but it remains debated whether it is still beneficial without the dietary control. The aim of this study was to determine both the peripheral and central effects of exercise training combined with a cholesterol-rich diet given ad libitum in old ApoE-/- mice. Methods : Forty-five-weeks old obese ApoE-/- mice fed with a high cholesterol diet ad libitum were divided into Exercise-trained (EX; running wheel free access) and Sedentary (SED) groups. Insulin tolerance and brain imaging were performed before and after the twelve-weeks training. Tissue insulin resistance, oxidative stress, and inflammation markers in plasma, aorta, and brain were then assessed. Results : In EX ApoE-/- mice, no beneficial effect of exercise was observed on weight, abdominal fat, metabolic parameters, oxidative stress, or inflammation compared to SED. Despite the regular exercise training in ApoE-/- EX mice (mean of 12.5 km/week during 12 weeks), brain inflammation imaging score was significantly associated with increased blood brain barrier (BBB) leakage evaluated by imaging follow-up (r2 = 0.87; p = 0.049) with a faster evolution compared to SED ApoE-/- mice. Conclusion : We conclude that in a context of high cardio-metabolic risk, exercise does not provide any protective effect in old ApoE-/--/- animals under high cholesterol diet given ad libitum. Peripheral (insulin sensitivity and oxidative/inflammatory status) but also central features (BBB preservation and protection against inflammation) did not show any benefits of exercise. Indeed, there was a fast induction of irreversible brain damage that was more pronounced in exercise-trained ApoE-/- mice. [ABSTRACT FROM AUTHOR]

Published
2016
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