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Harvest aids are traditionally used to desiccate weeds to improve crop quality and harvest efficiency. Field studies were conducted in Texas to determine the effect of harvest aids (glyphosate, diquat-dibromide, glufosinate-ammonium, and carfentrazone-ethyl) on sesame drydown and yield. The objective was to identify one or more harvest aids that could (1) accelerate drydown, (2) burn-down green weeds, (3) even up a field with varying levels of drydown, (4) stop regrowth, (5) stop vivipary, and (6) prepare to plant a new crop. Other than diquat-dibromide, the herbicides were chosen based on the effect on weeds in other crops. The plan was to apply the herbicides 1 week before physiological maturity (PM), at PM, and 1 week after PM. However, sesame maturity is very sensitive to ground moisture, ambient temperature, and relative humidity. The weather was different in all trials and some stages could not be completed. In two cases, the trials had to be abandoned; however, certain patterns emerged. All the herbicides accelerated drydown compared to the untreated check. Diquat-dibromide and glufosinate-ammonium dried sesame faster than glyphosate and carfentrazone-ethyl. The higher rates of the herbicide dried down the sesame faster than the low rate. Although there were some differences in yields across the three application periods, there was no consistent pattern.