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1,093 results on '"Langerak, Anton W."'

1. IκBε deficiency accelerates disease development in chronic lymphocytic leukemia

Author

Bordini, Jessica, Lenzi, Chiara, Frenquelli, Michela, Morabito, Alessia, Pseftogas, Athanasios, Belloni, Daniela, Mansouri, Larry, Tsiolas, George, Perotta, Eleonora, Ranghetti, Pamela, Gandini, Francesca, Genova, Francesca, Hägerstrand, Daniel, Gavriilidis, Georgios, Keisaris, Sofoklis, Pechlivanis, Nikolaos, Davi, Frederic, Kay, Neil E., Langerak, Anton W., Pospisilova, Sarka, Scarfò, Lydia, Makris, Antonios, Psomopoulos, Fotis E., Stamatopoulos, Kostas, Rosenquist, Richard, Campanella, Alessandro, and Ghia, Paolo

Published
2024
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2. ACVIM consensus statement guidelines on diagnosing and distinguishing low-grade neoplastic from inflammatory lymphocytic chronic enteropathies in cats.

Author

Marsilio, Sina, Freiche, Valerie, Johnson, Eric, Leo, Chiara, Langerak, Anton W, Peters, Iain, and Ackermann, Mark R

Subjects
Lymphocytes, Animals, Cats, Humans, Enteritis, Inflammatory Bowel Diseases, Cat Diseases, Prospective Studies, T-cell, alimentary, cat, chronic diarrhea, endoscopy, gastrointestinal, histology, immunohistochemistry, inflammatory bowel disease, lymphoma, lymphoplasmacytic enteritis, lymphoproliferative disorders, Clinical Research, Digestive Diseases, 4.1 Discovery and preclinical testing of markers and technologies, Detection, screening and diagnosis, Veterinary Sciences
Abstract

BackgroundLymphoplasmacytic enteritis (LPE) and low-grade intestinal T cell lymphoma (LGITL) are common diseases in older cats, but their diagnosis and differentiation remain challenging.ObjectivesTo summarize the current literature on etiopathogenesis and diagnosis of LPE and LGITL in cats and provide guidance on the differentiation between LPE and LGITL in cats. To provide statements established using evidence-based approaches or where such evidence is lacking, statements based on consensus of experts in the field.AnimalsNone.MethodsA panel of 6 experts in the field (2 internists, 1 radiologist, 1 anatomic pathologist, 1 clonality expert, 1 oncologist) with the support of a human medical immunologist, was formed to assess and summarize evidence in the peer-reviewed literature and complement it with consensus recommendations.ResultsDespite increasing interest on the topic for clinicians and pathologists, few prospective studies were available, and interpretation of the pertinent literature often was challenging because of the heterogeneity of the cases. Most recommendations by the panel were supported by a moderate or low level of evidence. Several understudied areas were identified, including cellular markers using immunohistochemistry, genomics, and transcriptomic studies.Conclusions and clinical importanceTo date, no single diagnostic criterion or known biomarker reliably differentiates inflammatory lesions from neoplastic lymphoproliferations in the intestinal tract of cats and a diagnosis currently is established by integrating all available clinical and diagnostic data. Histopathology remains the mainstay to better differentiate LPE from LGITL in cats with chronic enteropathy.

Published
2023

7. Impact of the Types and Relative Quantities of IGHV Gene Mutations in Predicting Prognosis of Patients With Chronic Lymphocytic Leukemia

Author

Kaufman, Matthew, Yan, Xiao-Jie, Li, Wentian, Ghia, Emanuela M, Langerak, Anton W, Rassenti, Laura Z, Belessi, Chrysoula, Kay, Neil E, Davi, Frederic, Byrd, John C, Pospisilova, Sarka, Brown, Jennifer R, Catherwood, Mark, Davis, Zadie, Oscier, David, Montillo, Marco, Trentin, Livio, Rosenquist, Richard, Ghia, Paolo, Barrientos, Jacqueline C, Kolitz, Jonathan E, Allen, Steven L, R., Kanti, Stamatopoulos, Kostas, Kipps, Thomas J, Neuberg, Donna, and Chiorazzi, Nicholas

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Lymphoma, Cancer, Hematology, Lymphatic Research, Rare Diseases, CLL, chronic lymphocytic leukemia, immunoglobulin variable domain, prognosis, somatic mutations, Oncology and Carcinogenesis, Clinical sciences, Oncology and carcinogenesis
Abstract

Patients with CLL with mutated IGHV genes (M-CLL) have better outcomes than patients with unmutated IGHVs (U-CLL). Since U-CLL usually express immunoglobulins (IGs) that are more autoreactive and more effectively transduce signals to leukemic B cells, B-cell receptor (BCR) signaling is likely at the heart of the worse outcomes of CLL cases without/few IGHV mutations. A corollary of this conclusion is that M-CLL follow less aggressive clinical courses because somatic IGHV mutations have altered BCR structures and no longer bind stimulatory (auto)antigens and so cannot deliver trophic signals to leukemic B cells. However, the latter assumption has not been confirmed in a large patient cohort. We tried to address the latter by measuring the relative numbers of replacement (R) mutations that lead to non-conservative amino acid changes (Rnc) to the combined numbers of conservative (Rc) and silent (S) amino acid R mutations that likely do not or cannot change amino acids, "(S+Rc) to Rnc IGHV mutation ratio". When comparing time-to-first-treatment (TTFT) of patients with (S+Rc)/Rnc ≤ 1 and >1, TTFTs were similar, even after matching groups for equal numbers of samples and identical numbers of mutations per sample. Thus, BCR structural change might not be the main reason for better outcomes for M-CLL. Since the total number of IGHV mutations associated better with longer TTFT, better clinical courses appear due to the biologic state of a B cell having undergone many stimulatory events leading to IGHV mutations. Analyses of larger patient cohorts will be needed to definitively answer this question.

Published
2022

9. Fixed-duration venetoclax plus obinutuzumab improves quality of life and geriatric impairments in FCR-unfit patients with CLL

Author

Beckers, M. M. J., Bekker, A., Bellido, M., de Boer, F., Broers, R., Chamuleau, M., Croockewit, A. J., Dompeling, E. C., Eefting, M., van Gelder, M., Hoogendoorn, M., Houtenbos, I., Doorduijn, J. K., Droogendijk, J., van der Griend, R., de Heer, K., Henkens, C. M. A., Idink, C. A. M., Issa, D. E., van Kampen, R., Kater, A. P., Kersting, S., van der Klift, M., Laterveer, L., Levenga, H., Levin, M-D., Mous, R., Nijland, M., Nijziel, M., van Norden, Y., Posthuma, E. F. M., te Raa, G. D., Raymakers, R. A. P., Regelink, J. C., Sandberg, Y., Schaafsma, M. R., Silbermann, M. H., van der Spek, A. C., van der Straaten, H. M., Tanis, B., Terpstra, W. E., Tick, L. W., Tonino, S. H., Veelken, J. H., Velders, G. A., Vlasveld, L., Visser, H. P. J., Vos, J. M. I., Wittebol, S., van Zaanen, H. C. T., van der Straten, Lina, Stege, Claudia A. M., Kersting, Sabina, Nasserinejad, Kazem, Dubois, Julie, Dobber, Johan A., Mellink, Clemens H. M., van der Kevie-Kersemaekers, Anne-Marie F., Evers, Ludo M., de Boer, Fransien, Koene, Harry R., Schreurs, John, van der Klift, Marjolein, Velders, Gerjo A., van der Spek, Ellen, van der Straaten, Hanneke M., Hoogendoorn, Mels, van Gelder, Michel, Posthuma, Eduardus F. M., Visser, Hein P. J., Houtenbos, Ilse, Idink, Cecile A. M., Issa, Djamila E., Dompeling, Ellen C., van Zaanen, Henk C. T., Veelken, J. Hendrik, Levenga, Henriette, Tick, Lidwine W., Terpstra, Wim E., Tonino, Sanne H., Westerweel, Peter E., Langerak, Anton W., Kater, Arnon P., and Levin, Mark-David

Published
2023
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10. Detecting measurable residual disease beyond 10−4 by an IGHV leader-based NGS approach improves prognostic stratification in CLL

Author

Hengeveld, Paul J., van der Klift, Michèle Y., Kolijn, P. Martijn, Davi, Frédéric, Kavelaars, François G., de Jonge, Evert, Robrecht, Sandra, Assmann, Jorn L. J. C., van der Straten, Lina, Ritgen, Matthias, Westerweel, Peter E., Fischer, Kirsten, Goede, Valentin, Hallek, Michael, Levin, Mark-David, and Langerak, Anton W.

Published
2023
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13. EuroClonality-NGS recommendations for evaluation of B cell clonality analysis by next-generation sequencing – a structured approach with the DEPART algorithm

Author

van den Brand, Michiel, Mobs, Markus, Otto, Franziska, Kroeze, Leonie I., Castro, David Gonzalez-de, Stamatopoulos, Kostas, Davi, Frederic, Bravetti, Clotilde, Kolijn, P. Martijn, Vlachonika, Elisavet, Stewart, J Peter, Pott, Christiane, Hummel, Michael, Darzentas, Nikos, Langerak, Anton W., Fend, Falko, and Groenen, Patricia JTA.

Published
2023
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14. Clinicobiological characteristics and treatment efficacy of novel agents in chronic lymphocytic leukemia with IGLV3-21R110

Author

Hengeveld, Paul J., Ertem, Y. Emre, Dubois, Julie M. N., Mellink, Clemens H. M., van der Kevie-Kersemaekers, Anne-Marie, Evers, Ludo M., Heezen, Kim, Kolijn, P. Martijn, Mook, Olaf R. F., Motazacker, M. Mahdi, Nasserinejad, Kazem, Kersting, S., Westerweel, Peter E., Niemann, Carsten U., Kater, Arnon P., Langerak, Anton W., and Levin, Mark-David

Published
2022
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17. High-risk subtypes of chronic lymphocytic leukemia are detectable as early as 16 years prior to diagnosis

Author

Kolijn, P. Martijn, Hosnijeh, Fatemeh Saberi, Späth, Florentin, Hengeveld, Paul J., Agathangelidis, Andreas, Saleh, Manal, Casabonne, Delphine, Benavente, Yolanda, Jerkeman, Mats, Agudo, Antonio, Barricarte, Aurelio, Besson, Caroline, Sánchez, Maria-Jose, Chirlaque, María-Dolores, Masala, Giovanna, Sacerdote, Carlotta, Grioni, Sara, Schulze, Matthias B., Nieters, Alexandra, Engelfriet, Peter, Hultdin, Magnus, McKay, James D., Vermeulen, Roel C.H., and Langerak, Anton W.

Published
2022
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19. B cell receptor signaling proteins as biomarkers for progression of CLL requiring first-line therapy.

Author

Vervoordeldonk, Mischa Y. L., Hengeveld, Paul J., Levin, Mark-David, and Langerak, Anton W.

Subjects
B cell receptors, CELL communication, CHRONIC lymphocytic leukemia, PROTEIN receptors, IMMUNOGLOBULIN heavy chains, CHRONIC leukemia
Abstract

The molecular landscape of chronic lymphocytic leukemia (CLL) has been extensively characterized, and various potent prognostic biomarkers were discovered. The genetic composition of the B-cell receptor (BCR) immunoglobulin (IG) was shown to be especially powerful for discerning indolent from aggressive disease at diagnosis. Classification based on the IG heavy chain variable gene (IGHV) somatic hypermutation status is routinely applied. Additionally, BCR IGH stereotypy has been implicated to improve risk stratification, through characterization of subsets with consistent clinical profiles. Despite these advances, it remains challenging to predict when CLL progresses to requiring first-line therapy, thus emphasizing the need for further refinement of prognostic indicators. Signaling pathways downstream of the BCR are essential in CLL pathogenesis, and dysregulated components within these pathways impact disease progression. Considering not only genomics but the entirety of factors shaping BCR signaling activity, this review offers insights in the disease for better prognostic assessment of CLL. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Association of Altered Plasma Lipidome with Disease Severity in COVID-19 Patients

Author

Zhang, Zhengzheng, primary, Karu, Naama, additional, Kindt, Alida, additional, Singh, Madhulika, additional, Lamont, Lieke, additional, van Gammeren, Adriaan J., additional, Ermens, Anton A. M., additional, Harms, Amy C., additional, Portengen, Lutzen, additional, Vermeulen, Roel C. H., additional, Dik, Willem A., additional, Langerak, Anton W., additional, van der Velden, Vincent H. J., additional, and Hankemeier, Thomas, additional

Published
2024
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21. Validation of the EuroClonality-NGS DNA capture panel as an integrated genomic tool for lymphoproliferative disorders

Author

Stewart, James Peter, Gazdova, Jana, Darzentas, Nikos, Wren, Dörte, Proszek, Paula, Fazio, Grazia, Songia, Simona, Alcoceba, Miguel, Sarasquete, Maria Eugenia, Villarese, Patrick, van der Klift, Michèle Y., Heezen, Kim C., McCafferty, Neil, Pal, Karol, Catherwood, Mark, Kim, Chang Sik, Srivastava, Shambhavi, Kroeze, Leonie I., Hodges, Elizabeth, Stamatopoulos, Kostas, Klapper, Wolfram, Genuardi, Elisa, Ferrero, Simone, van den Brand, Michiel, Cazzaniga, Giovanni, Davi, Frederic, Sutton, Lesley-Ann, Garcia-Sanz, Ramon, Groenen, Patricia J.T.A., Macintyre, Elizabeth A., Brüggemann, Monika, Pott, Christiane, Langerak, Anton W., and Gonzalez, David

Published
2021
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24. Higher-order connections between stereotyped subsets: implications for improved patient classification in CLL

Author

Agathangelidis, Andreas, Chatzidimitriou, Anastasia, Gemenetzi, Katerina, Giudicelli, Veronique, Karypidou, Maria, Plevova, Karla, Davis, Zadie, Yan, Xiao-Jie, Jeromin, Sabine, Schneider, Christof, Pedersen, Lone Bredo, Tschumper, Renee C., Sutton, Lesley-Ann, Baliakas, Panagiotis, Scarfò, Lydia, van Gastel, Ellen J., Armand, Marine, Tausch, Eugen, Biderman, Bella, Baer, Constance, Bagnara, Davide, Navarro, Alba, Langlois de Septenville, Anne, Guido, Valentina, Mitterbauer-Hohendanner, Gerlinde, Dimovski, Aleksandar, Brieghel, Christian, Lawless, Sarah, Meggendorfer, Manja, Brazdilova, Kamila, Ritgen, Matthias, Facco, Monica, Tresoldi, Cristina, Visentin, Andrea, Patriarca, Andrea, Catherwood, Mark, Bonello, Lisa, Sudarikov, Andrey, Vanura, Katrina, Roumelioti, Maria, Skuhrova Francova, Hana, Moysiadis, Theodoros, Veronese, Silvio, Giannopoulos, Krzysztof, Mansouri, Larry, Karan-Djurasevic, Teodora, Sandaltzopoulos, Raphael, Bödör, Csaba, Fais, Franco, Kater, Arnon, Panovska, Irina, Rossi, Davide, Alshemmari, Salem, Panagiotidis, Panagiotis, Costeas, Paul, Espinet, Blanca, Antic, Darko, Foroni, Letizia, Montillo, Marco, Trentin, Livio, Stavroyianni, Niki, Gaidano, Gianluca, Francia di Celle, Paola, Niemann, Carsten, Campo, Elias, Anagnostopoulos, Achilles, Pott, Christiane, Fischer, Kirsten, Hallek, Michael, Oscier, David, Stilgenbauer, Stephan, Haferlach, Claudia, Jelinek, Diane, Chiorazzi, Nicholas, Pospisilova, Sarka, Lefranc, Marie-Paule, Kossida, Sofia, Langerak, Anton W., Belessi, Chrysoula, Davi, Frederic, Rosenquist, Richard, Ghia, Paolo, and Stamatopoulos, Kostas

Published
2021
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26. Association of Altered Plasma Lipidome with Disease Severity in COVID-19 Patients

Author

IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Zhang, Zhengzheng, Karu, Naama, Kindt, Alida, Singh, Madhulika, Lamont, Lieke, van Gammeren, Adriaan J, Ermens, Anton A M, Harms, Amy C, Portengen, Lutzen, Vermeulen, Roel C H, Dik, Willem A, Langerak, Anton W, van der Velden, Vincent H J, Hankemeier, Thomas, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Zhang, Zhengzheng, Karu, Naama, Kindt, Alida, Singh, Madhulika, Lamont, Lieke, van Gammeren, Adriaan J, Ermens, Anton A M, Harms, Amy C, Portengen, Lutzen, Vermeulen, Roel C H, Dik, Willem A, Langerak, Anton W, van der Velden, Vincent H J, and Hankemeier, Thomas

Published
2024

27. Association of Altered Plasma Lipidome with Disease Severity in COVID-19 Patients

Author

Zhang, Zhengzheng, Karu, Naama, Kindt, Alida, Singh, Madhulika, Lamont, Lieke, van Gammeren, Adriaan J., Ermens, Anton A.M., Harms, Amy C., Portengen, Lutzen, Vermeulen, Roel C.H., Dik, Willem A., Langerak, Anton W., van der Velden, Vincent H.J., Hankemeier, Thomas, Zhang, Zhengzheng, Karu, Naama, Kindt, Alida, Singh, Madhulika, Lamont, Lieke, van Gammeren, Adriaan J., Ermens, Anton A.M., Harms, Amy C., Portengen, Lutzen, Vermeulen, Roel C.H., Dik, Willem A., Langerak, Anton W., van der Velden, Vincent H.J., and Hankemeier, Thomas

Abstract

The severity of COVID-19 is linked to an imbalanced immune response. The dysregulated metabolism of small molecules and bioactive lipids has also been associated with disease severity. To promote understanding of the disease biochemistry and provide targets for intervention, we applied a range of LC-MS platforms to analyze over 100 plasma samples from patients with varying COVID-19 severity and with detailed clinical information on inflammatory responses (>30 immune markers). This is the third publication in a series, and it reports the results of comprehensive lipidome profiling using targeted LC-MS/MS. We identified 1076 lipid features across 25 subclasses, including glycerophospholipids, sterols, glycerolipids, and sphingolipids, among which 531 lipid features were dramatically changed in the plasma of intensive care unit (ICU) patients compared to patients in the ward. Patients in the ICU showed 1.3–57-fold increases in ceramides, (lyso-)glycerophospholipids, diglycerides, triglycerides, and plasmagen phosphoethanolamines, and 1.3–2-fold lower levels of a cyclic lysophosphatidic acid, sphingosine-1-phosphates, sphingomyelins, arachidonic acid-containing phospholipids, lactosylceramide, and cholesterol esters compared to patients in the ward. Specifically, phosphatidylinositols (PIs) showed strong fatty acid saturation-dependent behavior, with saturated fatty acid (SFA)- and monosaturated fatty acid (MUFA)-derived PI decreasing and polystaturated (PUFA)-derived PI increasing. We also found ~4000 significant Spearman correlations between lipids and multiple clinical markers of immune response with |R| ≥ 0.35 and FDR corrected Q < 0.05. Except for lysophosphatidic acid, lysophospholipids were positively associated with the CD4 fraction of T cells, and the cytokines IL-8 and IL-18. In contrast, sphingosine-1-phosphates were negatively correlated with innate immune markers such as CRP and IL-6. Further indications of metabolic changes in moderate COVID-19 di

Published
2024

28. Clinical pilot study on microfluidic automation of IGH-VJ library preparation for next generation sequencing.

Author

Hess, Jacob F., Kotrová, Michaela, Fricke, Birgit, Songia, Simona, Rigamonti, Silvia, Cavagna, Roberta, Tosi, Manuela, Paust, Nils, Langerak, Anton W., Spinelli, Orietta, Cazzaniga, Giovanni, Brüggemann, Monika, and Hutzenlaub, Tobias

Subjects
NUCLEOTIDE sequencing, LIBRARY automation, AUTOMATION software, AUTOMATION, T-cell receptor genes, PILOT projects, WHOLE genome sequencing
Abstract

This document is a letter published in the journal Clinical Chemistry & Laboratory Medicine. It discusses a clinical pilot study on the automation of library preparation for next-generation sequencing (NGS) using microfluidics. The study focuses on the screening of somatic rearrangements of Immunoglobulin (IG) genes in patients with acute lymphoblastic leukemia (ALL). The researchers used a centrifugal microfluidic cartridge and a modified commercially available player for the automation process. The results showed that the automated library preparation using microfluidics was comparable to manual library preparation in terms of coverage and detection of IGH-VJ rearrangements. The study suggests that centrifugal microfluidic automation can reduce complexity and staff hands-on time in a clinical setup for library preparation. However, the choice of automation system depends on the throughput numbers of the laboratory. The researchers also mention the possibility of manufacturing cartridges for other lymphoid malignancies and the potential for MRD quantification by NGS. [Extracted from the article]

Published
2024
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30. Proteomic markers with prognostic impact on outcome of chronic lymphocytic leukemia patients under chemo-immunotherapy: results from the HOVON 109 study

Author

Saberi Hosnijeh, Fatemeh, van der Straten, Lina, Kater, Arnon P., van Oers, Marinus H.J., Posthuma, Ward F.M., Chamuleau, Martine E.D., Bellido, Mar, Doorduijn, Jeanette K., van Gelder, Michel, Hoogendoorn, Mels, de Boer, Fransien, te Raa, G. Doreen, Kerst, J. Martijn, Marijt, Erik W.A., Raymakers, Reinier A.P., Koene, Harry R., Schaafsma, Martijn R., Dobber, Johan A., Tonino, Sanne H., Kersting, Sabina S., Langerak, Anton W., and Levin, Mark-David

Published
2020
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31. BRAF V600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis

Author

Acosta-Medina, Aldo A., primary, Kemps, Paul G., additional, Zondag, Timo C. E., additional, Abeykoon, Jithma P., additional, Forma-Borst, Jelske, additional, Steenwijk, Eline C., additional, Feijen, Elizabeth A. M., additional, Teepen, Jop C., additional, Bennani, N. Nora, additional, Schram, Susan M., additional, Shah, Mithun V., additional, Davidge-Pitts, Caroline, additional, Koster, Matthew J., additional, Ryu, Jay H., additional, Vassallo, Robert, additional, Tobin, W. Oliver, additional, Young, Jason R., additional, Dasari, Surendra, additional, Rech, Karen, additional, Ravindran, Aishwarya, additional, Cleven, Arjen H. G., additional, Verdijk, Robert M., additional, van Noesel, Carel J. M., additional, Balgobind, Brian V., additional, Bouma, Gerrit Joan, additional, Saeed, Peerooz, additional, Bramer, Jos A. M., additional, de Groen, Ruben A. L., additional, Vermaat, Joost S. P., additional, van de Sande, Michiel A. J., additional, Smit, Egbert F., additional, Langerak, Anton W., additional, van Wezel, Tom, additional, Tonino, Sanne H., additional, van den Bos, Cor, additional, van Laar, Jan A. M., additional, Go, Ronald S., additional, Goyal, Gaurav, additional, and van Halteren, Astrid G. S., additional

Published
2023
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33. Genetic drivers in the natural history of chronic lymphocytic leukemia development as early as 16 years before diagnosis

Author

Kolijn, P. Martijn, primary, Späth, Florentin, additional, Khouja, Mouhamad, additional, Hengeveld, Paul J., additional, van der Straten, Lina, additional, Darzentas, Nikos, additional, Hultdin, Magnus, additional, McKay, James D., additional, Pott, Christiane, additional, Vermeulen, Roel C. H., additional, and Langerak, Anton W., additional

Published
2023
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34. Fixed-duration venetoclax plus obinutuzumab improves quality of life and geriatric impairments in FCR-unfit patients with CLL

Author

van der Straten, Lina, primary, Stege, Claudia A. M., additional, Kersting, Sabina, additional, Nasserinejad, Kazem, additional, Dubois, Julie, additional, Dobber, Johan A., additional, Mellink, Clemens H. M., additional, van der Kevie-Kersemaekers, Anne-Marie F., additional, Evers, Ludo M., additional, de Boer, Fransien, additional, Koene, Harry R., additional, Schreurs, John, additional, van der Klift, Marjolein, additional, Velders, Gerjo A., additional, van der Spek, Ellen, additional, van der Straaten, Hanneke M., additional, Hoogendoorn, Mels, additional, van Gelder, Michel, additional, Posthuma, Eduardus F. M., additional, Visser, Hein P. J., additional, Houtenbos, Ilse, additional, Idink, Cecile A. M., additional, Issa, Djamila E., additional, Dompeling, Ellen C., additional, van Zaanen, Henk C. T., additional, Veelken, J. Hendrik, additional, Levenga, Henriette, additional, Tick, Lidwine W., additional, Terpstra, Wim E., additional, Tonino, Sanne H., additional, Westerweel, Peter E., additional, Langerak, Anton W., additional, Kater, Arnon P., additional, and Levin, Mark-David, additional

Published
2023
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35. High-throughput Proteomics Identifies THEMIS2 as Independent Biomarker of Treatment-free Survival in Untreated CLL

Author

Hengeveld, Paul J., primary, Kolijn, P. Martijn, additional, Demmers, Jeroen A.A., additional, Doff, Wouter, additional, Dubois, Julie M.N., additional, Rijken, Melissa, additional, Assmann, Jorn L.J.C., additional, van der Straten, Lina, additional, Boiten, Henk Jan, additional, Gussinklo, Kirsten J., additional, Valk, Peter J.M., additional, Faber, Laura M., additional, Westerweel, Peter E., additional, Kater, Arnon P., additional, Levin, Mark-David, additional, and Langerak, Anton W., additional

Published
2023
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39. Next-generation sequencing of immunoglobulin gene rearrangements for clonality assessment: a technical feasibility study by EuroClonality-NGS

Author

Scheijen, Blanca, Meijers, Ruud W. J., Rijntjes, Jos, van der Klift, Michèle Y., Möbs, Markus, Steinhilber, Julia, Reigl, Tomas, van den Brand, Michiel, Kotrová, Michaela, Ritter, Julia-Marie, Catherwood, Mark A., Stamatopoulos, Kostas, Brüggemann, Monika, Davi, Frédéric, Darzentas, Nikos, Pott, Christiane, Fend, Falko, Hummel, Michael, Langerak, Anton W., Groenen, Patricia J. T. A., and on behalf of the EuroClonality-NGS Working Group

Published
2019
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40. Quality control and quantification in IG/TR next-generation sequencing marker identification: protocols and bioinformatic functionalities by EuroClonality-NGS

Author

Knecht, Henrik, Reigl, Tomas, Kotrová, Michaela, Appelt, Franziska, Stewart, Peter, Bystry, Vojtech, Krejci, Adam, Grioni, Andrea, Pal, Karol, Stranska, Kamila, Plevova, Karla, Rijntjes, Jos, Songia, Simona, Svatoň, Michael, Froňková, Eva, Bartram, Jack, Scheijen, Blanca, Herrmann, Dietrich, García-Sanz, Ramón, Hancock, Jeremy, Moppett, John, van Dongen, Jacques J. M., Cazzaniga, Giovanni, Davi, Frédéric, Groenen, Patricia J. T. A., Hummel, Michael, Macintyre, Elizabeth A., Stamatopoulos, Kostas, Trka, Jan, Langerak, Anton W., Gonzalez, David, Pott, Christiane, Brüggemann, Monika, Darzentas, Nikos, and on behalf of the EuroClonality-NGS Working Group

Published
2019
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41. Standardized next-generation sequencing of immunoglobulin and T-cell receptor gene recombinations for MRD marker identification in acute lymphoblastic leukaemia; a EuroClonality-NGS validation study

Author

Brüggemann, Monika, Kotrová, Michaela, Knecht, Henrik, Bartram, Jack, Boudjogrha, Myriam, Bystry, Vojtech, Fazio, Grazia, Froňková, Eva, Giraud, Mathieu, Grioni, Andrea, Hancock, Jeremy, Herrmann, Dietrich, Jiménez, Cristina, Krejci, Adam, Moppett, John, Reigl, Tomas, Salson, Mikael, Scheijen, Blanca, Schwarz, Martin, Songia, Simona, Svaton, Michael, van Dongen, Jacques J. M., Villarese, Patrick, Wakeman, Stephanie, Wright, Gary, Cazzaniga, Giovanni, Davi, Frédéric, García-Sanz, Ramón, Gonzalez, David, Groenen, Patricia J. T. A., Hummel, Michael, Macintyre, Elizabeth A., Stamatopoulos, Kostas, Pott, Christiane, Trka, Jan, Darzentas, Nikos, Langerak, Anton W., and on behalf of the EuroClonality-NGS working group

Published
2019
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44. Mediating effect of soluble B-cell activation immune markers on the association between anthropometric and lifestyle factors and lymphoma development

Author

Saberi Hosnijeh, Fatemeh, Kolijn, Pieter M., Casabonne, Delphine, Nieters, Alexandra, Solans, Marta, Naudin, Sabine, Ferrari, Pietro, Mckay, James D., Weiderpass, Elisabete, Perduca, Vittorio, Besson, Caroline, Mancini, Francesca Romana, Masala, Giovanna, Krogh, Vittorio, Ricceri, Fulvio, Huerta, José M., Petrova, Dafina, Sala, Núria, Trichopoulou, Antonia, Karakatsani, Anna, La Vecchia, Carlo, Kaaks, Rudolf, Canzian, Federico, Aune, Dagfinn, Boeing, Heiner, Schulze, Matthias B., Perez-Cornago, Aurora, Langerak, Anton W., van der Velden, Vincent H. J., and Vermeulen, Roel

Published
2020
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47. Targeted multiomics in childhood-onset SLE reveal distinct biological phenotypes associated with disease activity: results from an explorative study

Author

Wahadat, Mohamed Javad, primary, van Tilburg, Sander J, additional, Mueller, Yvonne M, additional, de Wit, Harm, additional, Van Helden-Meeuwsen, Cornelia G, additional, Langerak, Anton W, additional, Gruijters, Marike J, additional, Mubarak, Amani, additional, Verkaaik, Marleen, additional, Katsikis, Peter D, additional, Versnel, Marjan A, additional, and Kamphuis, Sylvia, additional

Published
2023
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48. Figure S2B from Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors: Shared and Distinct Immunogenetic Features and Clinical Outcomes

Author

Xochelli, Aliki, primary, Baliakas, Panagiotis, primary, Kavakiotis, Ioannis, primary, Agathangelidis, Andreas, primary, Sutton, Lesley-Ann, primary, Minga, Eva, primary, Ntoufa, Stavroula, primary, Tausch, Eugen, primary, Yan, Xiao-Jie, primary, Shanafelt, Tait, primary, Plevova, Karla, primary, Boudjogra, Myriam, primary, Rossi, Davide, primary, Davis, Zadie, primary, Navarro, Alba, primary, Sandberg, Yorick, primary, Vojdeman, Fie Juhl, primary, Scarfo, Lydia, primary, Stavroyianni, Niki, primary, Sudarikov, Andrey, primary, Veronese, Silvio, primary, Tzenou, Tatiana, primary, Karan-Djurasevic, Teodora, primary, Catherwood, Mark, primary, Kienle, Dirk, primary, Chatzouli, Maria, primary, Facco, Monica, primary, Bahlo, Jasmin, primary, Pott, Christiane, primary, Pedersen, Lone Bredo, primary, Mansouri, Larry, primary, Smedby, Karin E., primary, Chu, Charles C., primary, Giudicelli, Véronique, primary, Lefranc, Marie-Paule, primary, Panagiotidis, Panagiotis, primary, Juliusson, Gunnar, primary, Anagnostopoulos, Achilles, primary, Vlahavas, Ioannis, primary, Antic, Darko, primary, Trentin, Livio, primary, Montillo, Marco, primary, Niemann, Carsten, primary, Döhner, Hartmut, primary, Langerak, Anton W., primary, Pospisilova, Sarka, primary, Hallek, Michael, primary, Campo, Elias, primary, Chiorazzi, Nicholas, primary, Maglaveras, Nikos, primary, Oscier, David, primary, Gaidano, Gianluca, primary, Jelinek, Diane F., primary, Stilgenbauer, Stephan, primary, Chouvarda, Ioanna, primary, Darzentas, Nikos, primary, Belessi, Chrysoula, primary, Davi, Frederic, primary, Hadzidimitriou, Anastasia, primary, Rosenquist, Richard, primary, Ghia, Paolo, primary, and Stamatopoulos, Kostas, primary

Published
2023
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49. Table S1 from Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors: Shared and Distinct Immunogenetic Features and Clinical Outcomes

Author

Xochelli, Aliki, primary, Baliakas, Panagiotis, primary, Kavakiotis, Ioannis, primary, Agathangelidis, Andreas, primary, Sutton, Lesley-Ann, primary, Minga, Eva, primary, Ntoufa, Stavroula, primary, Tausch, Eugen, primary, Yan, Xiao-Jie, primary, Shanafelt, Tait, primary, Plevova, Karla, primary, Boudjogra, Myriam, primary, Rossi, Davide, primary, Davis, Zadie, primary, Navarro, Alba, primary, Sandberg, Yorick, primary, Vojdeman, Fie Juhl, primary, Scarfo, Lydia, primary, Stavroyianni, Niki, primary, Sudarikov, Andrey, primary, Veronese, Silvio, primary, Tzenou, Tatiana, primary, Karan-Djurasevic, Teodora, primary, Catherwood, Mark, primary, Kienle, Dirk, primary, Chatzouli, Maria, primary, Facco, Monica, primary, Bahlo, Jasmin, primary, Pott, Christiane, primary, Pedersen, Lone Bredo, primary, Mansouri, Larry, primary, Smedby, Karin E., primary, Chu, Charles C., primary, Giudicelli, Véronique, primary, Lefranc, Marie-Paule, primary, Panagiotidis, Panagiotis, primary, Juliusson, Gunnar, primary, Anagnostopoulos, Achilles, primary, Vlahavas, Ioannis, primary, Antic, Darko, primary, Trentin, Livio, primary, Montillo, Marco, primary, Niemann, Carsten, primary, Döhner, Hartmut, primary, Langerak, Anton W., primary, Pospisilova, Sarka, primary, Hallek, Michael, primary, Campo, Elias, primary, Chiorazzi, Nicholas, primary, Maglaveras, Nikos, primary, Oscier, David, primary, Gaidano, Gianluca, primary, Jelinek, Diane F., primary, Stilgenbauer, Stephan, primary, Chouvarda, Ioanna, primary, Darzentas, Nikos, primary, Belessi, Chrysoula, primary, Davi, Frederic, primary, Hadzidimitriou, Anastasia, primary, Rosenquist, Richard, primary, Ghia, Paolo, primary, and Stamatopoulos, Kostas, primary

Published
2023
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50. Extranodal marginal zone lymphoma clonotypes are detectable prior to eMZL diagnosis in tissue biopsies and peripheral blood of Sjögren’s syndrome patients through immunogenetics

Author

Kolijn, P. Martijn, primary, Huijser, Erika, additional, Wahadat, M. Javad, additional, van Helden-Meeuwsen, Cornelia G., additional, van Daele, Paul L. A., additional, Brkic, Zana, additional, Rijntjes, Jos, additional, Hebeda, Konnie M., additional, Groenen, Patricia J. T. A., additional, Versnel, Marjan A., additional, Thurlings, Rogier M., additional, and Langerak, Anton W., additional

Published
2023
Full Text
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