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3. Highly contiguous genomes of human clinical isolates of Giardia duodenalis reveal assemblage- and sub-assemblage-specific presence–absence variation in protein-coding genes

Author

Klotz, Christian, Schmid, Marc William, Winter, Katja, Ignatius, Ralf, Weisz, Filip, Saghaug, Christina Skar, Langeland, Nina, Dawson, Scott, Lalle, Marco, Hanevik, Kurt, Cacciò, Simone M, and Aebischer, Toni

Subjects
Digestive Diseases, Infectious Diseases, Biotechnology, Human Genome, Vaccine Related, Genetics, Aetiology, 2.2 Factors relating to the physical environment, Infection, Humans, Giardia lamblia, Giardiasis, Giardia, Genomics, Giardia duodenalis, allelic sequence heterozygosity, comparative genomics, protozoa, Microbiology
Abstract

Giardia duodenalis (syn. G. intestinalis, G. lamblia) is a widespread gastrointestinal protozoan parasite with debated taxonomic status. Currently, eight distinct genetic sub-groups, termed assemblages A-H, are defined based on a few genetic markers. Assemblages A and B may represent distinct species and are both of human public health relevance. Genomic studies are scarce and the few reference genomes available, in particular for assemblage B, are insufficient for adequate comparative genomics. Here, by combining long- and short-read sequences generated by PacBio and Illumina sequencing technologies, we provide nine annotated genome sequences for reference from new clinical isolates (four assemblage A and five assemblage B parasite isolates). Isolates chosen represent the currently accepted classification of sub-assemblages AI, AII, BIII and BIV. Synteny over the whole genome was generally high, but we report chromosome-level translocations as a feature that distinguishes assemblage A from B parasites. Orthologue gene group analysis was used to define gene content differences between assemblage A and B and to contribute a gene-set-based operational definition of respective taxonomic units. Giardia is tetraploid, and high allelic sequence heterogeneity (ASH) for assemblage B vs. assemblage A has been observed so far. Noteworthy, here we report an extremely low ASH (0.002%) for one of the assemblage B isolates (a value even lower than the reference assemblage A isolate WB-C6). This challenges the view of low ASH being a notable feature that distinguishes assemblage A from B parasites, and low ASH allowed assembly of the most contiguous assemblage B genome currently available for reference. In conclusion, the description of nine highly contiguous genome assemblies of new isolates of G. duodenalis assemblage A and B adds to our understanding of the genomics and species population structure of this widespread zoonotic parasite.

Published
2023

4. Three doses of Sars-CoV-2 mRNA vaccine in older adults result in similar antibody responses but reduced cellular cytokine responses relative to younger adults

Author

Bredholt, Geir, Sævik, Marianne, Søyland, Hanne, Ueland, Thor, Zhou, Fan, Pathirana, Rishi, Madsen, Anders, Vahokoski, Juha, Lartey, Sarah, Halvorsen, Bente E., Dahl, Tuva B., Trieu, Mai-Chi, Mohn, Kristin G.-I., Brokstad, Karl Albert, Aukrust, Pål, Tøndel, Camilla, Langeland, Nina, Blomberg, Bjørn, and Cox, Rebecca Jane

Published
2024
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9. Author Correction: Titers of antibodies against ancestral SARS-CoV-2 correlate with levels of neutralizing antibodies to multiple variants

Author

Tran, Trung The, Vaage, Eline Benno, Mehta, Adi, Chopra, Adity, Tietze, Lisa, Kolderup, Anette, Anthi, Aina, König, Marton, Nygaard, Gro, Lind, Andreas, Müller, Fredrik, Nissen-Meyer, Lise Sofie, Magnus, Per, Trogstad, Lill, Mjaaland, Siri, Søraas, Arne, Midtvedt, Karsten, Åsberg, Anders, Barratt-Due, Andreas, Medhus, Asle W., Høivik, Marte Lie, Lundin, Knut, Karlsen, Randi Fuglaas, Dahle, Reidun, Danielsson, Karin, Thomassen, Kristine Stien, Kro, Grete Birkeland, Cox, Rebecca J., Zhou, Fan, Langeland, Nina, Aukrust, Pål, Melum, Espen, Åvitsland, Tone Lise, Wiencke, Kristine, Holter, Jan Cato, Munthe, Ludvig A., Grødeland, Gunnveig, Andersen, Jan-Terje, Vaage, John Torgils, and Lund-Johansen, Fridtjof

Published
2023
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12. Spatiotemporal variation in risk of Shigella infection in childhood: a global risk mapping and prediction model using individual participant data

Author

Badr, Hamada S, Colston, Josh M, Nguyen, Nhat-Lan H, Chen, Yen Ting, Burnett, Eleanor, Ali, Syed Asad, Rayamajhi, Ajit, Satter, Syed M, Van Trang, Nguyen, Eibach, Daniel, Krumkamp, Ralf, May, Jürgen, Adegnika, Ayola Akim, Manouana, Gédéon Prince, Kremsner, Peter Gottfried, Chilengi, Roma, Hatyoka, Luiza, Debes, Amanda K, Ateudjieu, Jerome, Faruque, Abu S G, Hossain, M Jahangir, Kanungo, Suman, Kotloff, Karen L, Mandomando, Inácio, Nisar, M Imran, Omore, Richard, Sow, Samba O, Zaidi, Anita K M, Lambrecht, Nathalie, Adu, Bright, Page, Nicola, Platts-Mills, James A, Mavacala Freitas, Cesar, Pelkonen, Tuula, Ashorn, Per, Maleta, Kenneth, Ahmed, Tahmeed, Bessong, Pascal, Bhutta, Zulfiqar A, Mason, Carl, Mduma, Estomih, Olortegui, Maribel P, Peñataro Yori, Pablo, Lima, Aldo A M, Kang, Gagandeep, Humphrey, Jean, Ntozini, Robert, Prendergast, Andrew J, Okada, Kazuhisa, Wongboot, Warawan, Langeland, Nina, Moyo, Sabrina J, Gaensbauer, James, Melgar, Mario, Freeman, Matthew, Chard, Anna N, Thongpaseuth, Vonethalom, Houpt, Eric, Zaitchik, Benjamin F, and Kosek, Margaret N

Published
2023
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13. The Impact of a Model Partnership in a Medical Postgraduate Program in North-South and South-South Collaboration on Trainee Retention, Program Sustainability and Regional Collaboration

Author

Amare, Beede Lemma, Lutale, Janet, Derbew, Miliard, Mathai, Dilip, and Langeland, Nina

Abstract

North-South educational partnerships can potentially alleviate the scarcity of health work force in the South. A model program with the objectives of sustainability, high trainee retention, quality education, and capacity building is the goal of many similar programs. To achieve these goals a program of postgraduate clinical specialty training was implemented, between the University of Bergen, Norway and three Universities in Africa and one medical school in India between 2008 to 2014. This partnership program aimed at educating physicians from the South to specialize in various medical field. The goal was that the trained physicians would be educators in their respective countries. The program participants were 58 medical doctors. At the end of the program we conducted an evaluation survey involving program participants and coordinators. Twenty-eight physicians (48%) responded to the survey. The average program evaluation score by the physicians was 4.5 (out of a maximum of 5) with a range of 3.2 to 5. Out of the 12 program coordinators 9 (75%) responded to the survey. Their average score was 4.5 with a range of 4 to 4.9. By the time the survey was conducted, 49 of the 58 (84.5%) program participants had completed the program successfully and 47 of the 49 (95.9%) were working in their own countries. In conclusion, the partnership program was effective in capacity building in the development of the human health workforce in Africa. We have observed a high retention rate, good quality education, a sustainable program and the model can easily be reproducible.

Published
2017

14. Identification of conserved candidate vaccine antigens in the surface proteome of Giardia lamblia

Author

Davids, Barbara J, Liu, Ching M, Hanson, Elaine M, Le, Christine, Ang, Jonathan, Hanevik, Kurt, Fischer, Marvin, Radunovic, Matej, Langeland, Nina, Ferella, Marcela, Svärd, Staffan G, Ghassemian, Majid, Miyamoto, Yukiko, and Eckmann, Lars

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Biological Sciences, Prevention, Biotechnology, Digestive Diseases, Infectious Diseases, Vaccine Related, Emerging Infectious Diseases, Biodefense, Foodborne Illness, Immunization, Prevention of disease and conditions, and promotion of well-being, 3.4 Vaccines, Infection, Zero Hunger, Adult, Animals, Antibodies, Protozoan, Antigens, Protozoan, Cross Reactions, Female, Giardia lamblia, Giardiasis, Humans, Male, Mass Spectrometry, Mice, Mice, Inbred C57BL, Middle Aged, Proteome, Protozoan Proteins, Protozoan Vaccines, Young Adult, giardiasis, immunization, surface antigens, vaccines, Agricultural and Veterinary Sciences, Medical and Health Sciences, Microbiology, Immunology, Medical microbiology
Abstract

Giardia lamblia, one of the most common protozoal infections of the human intestine, is an important worldwide cause of diarrheal disease, malabsorption, malnutrition, delayed cognitive development in children, and protracted postinfectious syndromes. Despite its medical importance, no human vaccine is available against giardiasis. A crude veterinary vaccine has been developed, and experimental vaccines based on expression of multiple variant-specific surface proteins have been reported, but poorly defined vaccine components and excessive antigen variability are problematic for pharmaceutical vaccine production. To expand the repertoire of antigen candidates for vaccines, we reasoned that surface proteins may provide an enriched source of such antigens since key host effectors, such as secretory IgA, can directly bind to such antigens in the intestinal lumen and interfere with epithelial attachment. Here, we have applied a proteomics approach to identify 23 novel surface antigens of G. lamblia that show >90% amino acid sequence identity between the two human-pathogenic genetic assemblages (A and B) of the parasite. Surface localization of a representative subset of these proteins was confirmed by immunostaining. Four selected proteins, uridine phosphorylase-like protein-1, protein 21.1 (GL50803_27925), α1-giardin, and α11-giardin, were subsequently produced in recombinant form and shown to be immunogenic in mice and G. lamblia-infected humans and confer protection against G. lamblia infection upon intranasal immunization in rodent models of giardiasis. These results demonstrate that identification of conserved surface antigens provides a powerful approach for overcoming a key rate-limiting step in the design and construction of an effective vaccine against giardiasis.

Published
2019

17. A rapid antibody screening haemagglutination test for predicting immunity to SARS-CoV-2 variants of concern

Author

Ertesvåg, Nina Urke, Xiao, Julie, Zhou, Fan, Ljostveit, Sonja, Sandnes, Helene, Lartey, Sarah, Sævik, Marianne, Hansen, Lena, Madsen, Anders, Mohn, Kristin G. I., Fjelltveit, Elisabeth, Olofsson, Jan Stefan, Tan, Tiong Kit, Rijal, Pramila, Schimanski, Lisa, Øyen, Siri, Brokstad, Karl Albert, Dunachie, Susanna, Jämsén, Anni, James, William S., Harding, Adam C., Harvala, Heli, Nguyen, Dung, Roberts, David, Zambon, Maria, Townsend, Alain, Langeland, Nina, and Cox, Rebecca Jane

Published
2022
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19. Titers of antibodies against ancestral SARS-CoV-2 correlate with levels of neutralizing antibodies to multiple variants

Author

Tran, Trung The, Vaage, Eline Benno, Mehta, Adi, Chopra, Adity, Tietze, Lisa, Kolderup, Anette, Anthi, Aina, König, Marton, Nygaard, Gro, Lind, Andreas, Müller, Fredrik, Nissen-Meyer, Lise Sofie, Magnus, Per, Trogstad, Lill, Mjaaland, Siri, Søraas, Arne, Midtvedt, Karsten, Åsberg, Anders, Barratt-Due, Andreas, Medhus, Asle W., Høivk, Marte Lie, Lundin, Knut, Karlsen, Randi Fuglaas, Dahle, Reidun, Danielsson, Karin, Thomassen, Kristine Stien, Kro, Grete Birkeland, Cox, Rebecca J., Zhou, Fan, Langeland, Nina, Aukrust, Pål, Melum, Espen, Åvitsland, Tone Lise, Wiencke, Kristine, Holter, Jan Cato, Munthe, Ludvig A., Grødeland, Gunnveig, Andersen, Jan-Terje, Vaage, John Torgils, and Lund-Johansen, Fridtjof

Published
2022
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20. Predominance of multidrug-resistant Salmonella Typhi genotype 4.3.1 with low-level ciprofloxacin resistance in Zanzibar

Author

Onken, Annette, primary, Moyo, Sabrina, additional, Miraji, Mohammed Khamis, additional, Bohlin, Jon, additional, Marijani, Msafiri, additional, Manyahi, Joel, additional, Kibwana, Kibwana Omar, additional, Müller, Fredrik, additional, Jenum, Pål A., additional, Abeid, Khamis Ali, additional, Reimers, Marianne, additional, Langeland, Nina, additional, Mørch, Kristine, additional, and Blomberg, Bjørn, additional

Published
2024
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31. Post COVID-19 condition after delta infection and omicron reinfection in children and adolescents

Author

Ertesvåg, Nina Urke, primary, Iversen, Arild, additional, Blomberg, Bjørn, additional, Özgümüş, Türküler, additional, Rijal, Pramila, additional, Fjelltveit, Elisabeth Berg, additional, Cox, Rebecca Jane, additional, Langeland, Nina, additional, Haug, Kjell, additional, Sandnes, Helene, additional, Mohn, Kristin G-I, additional, Olofsson, Jan Stefan, additional, Sævik, Marianne, additional, Brokstad, Christopher James, additional, Kuwelker, Kanika, additional, and Heienberg, Kristin, additional

Published
2023
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33. SARS-CoV-2 specific immune responses in overweight and obese COVID-19 patients.

Author

Bredholt Onyango, Therese, Fan Zhou, Bredholt, Geir, Brokstad, Karl A., Lartey, Sarah, Mohn, Kristin G.-I., Özgümüs, Türküler, Kittang, Bård Reiakvam, Linchausen, Dagrun Waag, Shafiani, Shahin, Elyanow, Rebecca, Blomberg, Bjørn, Langeland, Nina, and Cox, Rebecca Jane

Subjects
COVID-19, COMPULSIVE eating, IMMUNE response, SARS-CoV-2, T cell receptors, OBESITY
Abstract

Obesity is a known risk factor for severe respiratory tract infections. In this prospective study, we assessed the impact of being obese or overweight on longitudinal SARS-CoV-2 humoral and cellular responses up to 18 months after infection. 274 patients provided blood samples at regular time intervals up to 18 months including obese (BMI ≥30, n=32), overweight (BMI 25-29.9, n=103) and normal body weight (BMI 18.5-24.9, n=134) SARS-CoV-2 patients. We determined SARS-CoV-2 spike-specific IgG, IgA, IgM levels by ELISA and neutralising antibody titres by neutralisation assay. RBD- and spike-specific memory B cells were investigated by ELISpot, spike- and non-spike-specific IFN-g, IL-2 and IFN-g/IL-2 secreting T cells by FluoroSpot and T cell receptor (TCR) sequencing was performed. Higher BMI correlated with increased COVID-19 severity. Humoral and cellular responses were stronger in overweight and obese patients than normal weight patients and associated with higher spike-specific IgG binding titres relative to neutralising antibody titres. Linear regression models demonstrated that BMI, age and COVID-19 severity correlated independently with higher SARS-CoV-2 immune responses. We found an increased proportion of unique SARS-CoV-2 specific T cell clonotypes after infection in overweight and obese patients. COVID-19 vaccination boosted humoral and cellular responses irrespective of BMI, although stronger immune boosting was observed in normal weight patients. Overall, our results highlight more severe disease and an overreactivity of the immune system in overweight and obese patients after SARSCoV-2 infection, underscoring the importance of recognizing overweight/obese individuals as a risk group for prioritisation for COVID-19 vaccination. [ABSTRACT FROM AUTHOR]

Published
2023
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34. Durable immune responses after BNT162b2 vaccination in home-dwelling old adults

Author

Hansen, Lena, primary, Brokstad, Karl Albert, additional, Bansal, Amit, additional, Zhou, Fan, additional, Bredholt, Geir, additional, Onyango, Therese Bredholt, additional, Sandnes, Helene Heitmann, additional, Elyanow, Rebecca, additional, Madsen, Anders, additional, Trieu, Mai-Chi, additional, Sævik, Marianne, additional, Søyland, Hanne, additional, Olofsson, Jan Stefan, additional, Vahokoski, Juha, additional, Ertesvåg, Nina Urke, additional, Fjelltveit, Elisabeth Berg, additional, Shafiani, Shahin, additional, Tøndel, Camilla, additional, Chapman, Heidi, additional, Kaplan, Ian, additional, Mohn, Kristin G.I., additional, Langeland, Nina, additional, and Cox, Rebecca Jane, additional

Published
2023
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41. Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders

Author

Eijsbouts, Chris, Zheng, Tenghao, Kennedy, Nicholas A., Bonfiglio, Ferdinando, Anderson, Carl A., Moutsianas, Loukas, Holliday, Joanne, Shi, Jingchunzi, Shringarpure, Suyash, Voda, Alexandru-Ioan, Farrugia, Gianrico, Franke, Andre, H��benthal, Matthias, Abecasis, Gon��alo, Zawistowski, Matthew, Skogholt, Anne Heidi, Ness-Jensen, Eivind, Hveem, Kristian, Esko, T��nu, Teder-Laving, Maris, Zhernakova, Alexandra, Camilleri, Michael, Boeckxstaens, Guy, Whorwell, Peter J., Spiller, Robin, McVean, Gil, D���Amato, Mauro, Jostins, Luke, Parkes, Miles, Agee, Michelle, Aslibekyan, Stella, Auton, Adam, Bell, Robert K., Bryc, Katarzyna, Clark, Sarah K., Elson, Sarah L., Fletez-Brant, Kipper, Fontanillas, Pierre, Furlotte, Nicholas A., Gandhi, Pooja M., Heilbron, Karl, Hicks, Barry, Hinds, David A., Huber, Karen E., Jewett, Ethan M., Jiang, Yunxuan, Kleinman, Aaron, Lin, Keng-Han, Litterman, Nadia K., Luff, Marie K., McCreight, Jey C., McIntyre, Matthew H., McManus, Kimberly F., Mountain, Joanna L., Mozaffari, Sahar V., Nandakumar, Priyanka, Noblin, Elizabeth S., Northover, Carrie A. M., O���Connell, Jared, Petrakovitz, Aaron A., Pitts, Steven J., Poznik, G. David, Sathirapongsasuti, J. Fah, Shastri, Anjali J., Shelton, Janie F., Tian, Chao, Tung, Joyce Y., Tunney, Robert J., Vacic, Vladimir, Wang, Xin, Zare, Amir S., Kashyap, Purna, Chang, Lin, Mayer, Emeran, Heitkemper, Margaret, Sayuk, Gregory S., Ringel-Kulka, Tamar, Ringel, Yehuda, Chey, William D., Eswaran, Shanti, Merchant, Juanita L., Shulman, Robert J., Bujanda, Luis, Garcia-Etxebarria, Koldo, Dlugosz, Aldona, Lindberg, Greger, Schmidt, Peter T., Karling, Pontus, Ohlsson, Bodil, Walter, Susanna, Faresj��, ��shild O., Simren, Magnus, Halfvarson, Jonas, Portincasa, Piero, Barbara, Giovanni, Usai-Satta, Paolo, Neri, Matteo, Nardone, Gerardo, Cuomo, Rosario, Galeazzi, Francesca, Bellini, Massimo, Latiano, Anna, Houghton, Lesley, Jonkers, Daisy, Kurilshikov, Alexander, Weersma, Rinse K., Netea, Mihai, Tesarz, Jonas, Gauss, Annika, Goebel-Stengel, Miriam, Andresen, Viola, Frieling, Thomas, Pehl, Christian, Schaefert, Rainer, Niesler, Beate, Lieb, Wolfgang, Hanevik, Kurt, Langeland, Nina, Wensaas, Knut-Arne, Litleskare, Sverre, Gabrielsen, Maiken E., Thomas, Laurent, Thijs, Vincent, Lemmens, Robin, Van Oudenhove, Lukas, Wouters, Mira, Eijsbouts C., Zheng T., Kennedy N.A., Bonfiglio F., Anderson C.A., Moutsianas L., Holliday J., Shi J., Shringarpure S., Agee M., Aslibekyan S., Auton A., Bell R.K., Bryc K., Clark S.K., Elson S.L., Fletez-Brant K., Fontanillas P., Furlotte N.A., Gandhi P.M., Heilbron K., Hicks B., Hinds D.A., Huber K.E., Jewett E.M., Jiang Y., Kleinman A., Lin K.-H., Litterman N.K., Luff M.K., McCreight J.C., McIntyre M.H., McManus K.F., Mountain J.L., Mozaffari S.V., Nandakumar P., Noblin E.S., Northover C.A.M., O'Connell J., Petrakovitz A.A., Pitts S.J., Poznik G.D., Sathirapongsasuti J.F., Shastri A.J., Shelton J.F., Tian C., Tung J.Y., Tunney R.J., Vacic V., Wang X., Zare A.S., Voda A.-I., Kashyap P., Chang L., Mayer E., Heitkemper M., Sayuk G.S., Ringel-Kulka T., Ringel Y., Chey W.D., Eswaran S., Merchant J.L., Shulman R.J., Bujanda L., Garcia-Etxebarria K., Dlugosz A., Lindberg G., Schmidt P.T., Karling P., Ohlsson B., Walter S., Faresjo A.O., Simren M., Halfvarson J., Portincasa P., Barbara G., Usai-Satta P., Neri M., Nardone G., Cuomo R., Galeazzi F., Bellini M., Latiano A., Houghton L., Jonkers D., Kurilshikov A., Weersma R.K., Netea M., Tesarz J., Gauss A., Goebel-Stengel M., Andresen V., Frieling T., Pehl C., Schaefert R., Niesler B., Lieb W., Hanevik K., Langeland N., Wensaas K.-A., Litleskare S., Gabrielsen M.E., Thomas L., Thijs V., Lemmens R., Van Oudenhove L., Wouters M., Farrugia G., Franke A., Hubenthal M., Abecasis G., Zawistowski M., Skogholt A.H., Ness-Jensen E., Hveem K., Esko T., Teder-Laving M., Zhernakova A., Camilleri M., Boeckxstaens G., Whorwell P.J., Spiller R., McVean G., D'Amato M., Jostins L., Parkes M., Eijsbouts, Chris [0000-0001-5179-0653], Anderson, Carl A. [0000-0003-1719-7009], Moutsianas, Loukas [0000-0001-5453-345X], Holliday, Joanne [0000-0003-4568-7320], Shringarpure, Suyash [0000-0001-6464-2668], Voda, Alexandru-Ioan [0000-0003-2974-6992], Farrugia, Gianrico [0000-0003-3473-5235], Hübenthal, Matthias [0000-0002-5956-3006], Abecasis, Gonçalo [0000-0003-1509-1825], Zawistowski, Matthew [0000-0002-3005-083X], Ness-Jensen, Eivind [0000-0001-6005-0729], Teder-Laving, Maris [0000-0002-5872-1850], Camilleri, Michael [0000-0001-6472-7514], Whorwell, Peter J. [0000-0002-5220-8474], Spiller, Robin [0000-0001-6371-4500], McVean, Gil [0000-0002-5012-4162], D’Amato, Mauro [0000-0003-2743-5197], Jostins, Luke [0000-0002-2475-3969], Parkes, Miles [0000-0002-6467-0631], Apollo - University of Cambridge Repository, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Translational Immunology Groningen (TRIGR), Eijsbouts, C., Zheng, T., Kennedy, N. A., Bonfiglio, F., Anderson, C. A., Moutsianas, L., Holliday, J., Shi, J., Shringarpure, S., Agee, M., Aslibekyan, S., Auton, A., Bell, R. K., Bryc, K., Clark, S. K., Elson, S. L., Fletez-Brant, K., Fontanillas, P., Furlotte, N. A., Gandhi, P. M., Heilbron, K., Hicks, B., Hinds, D. A., Huber, K. E., Jewett, E. M., Jiang, Y., Kleinman, A., Lin, K. -H., Litterman, N. K., Luff, M. K., Mccreight, J. C., Mcintyre, M. H., Mcmanus, K. F., Mountain, J. L., Mozaffari, S. V., Nandakumar, P., Noblin, E. S., Northover, C. A. M., O'Connell, J., Petrakovitz, A. A., Pitts, S. J., Poznik, G. D., Sathirapongsasuti, J. F., Shastri, A. J., Shelton, J. F., Tian, C., Tung, J. Y., Tunney, R. J., Vacic, V., Wang, X., Zare, A. S., Voda, A. -I., Kashyap, P., Chang, L., Mayer, E., Heitkemper, M., Sayuk, G. S., Ringel-Kulka, T., Ringel, Y., Chey, W. D., Eswaran, S., Merchant, J. L., Shulman, R. J., Bujanda, L., Garcia-Etxebarria, K., Dlugosz, A., Lindberg, G., Schmidt, P. T., Karling, P., Ohlsson, B., Walter, S., Faresjo, A. O., Simren, M., Halfvarson, J., Portincasa, P., Barbara, G., Usai-Satta, P., Neri, M., Nardone, G., Cuomo, R., Galeazzi, F., Bellini, M., Latiano, A., Houghton, L., Jonkers, D., Kurilshikov, A., Weersma, R. K., Netea, M., Tesarz, J., Gauss, A., Goebel-Stengel, M., Andresen, V., Frieling, T., Pehl, C., Schaefert, R., Niesler, B., Lieb, W., Hanevik, K., Langeland, N., Wensaas, K. -A., Litleskare, S., Gabrielsen, M. E., Thomas, L., Thijs, V., Lemmens, R., Van Oudenhove, L., Wouters, M., Farrugia, G., Franke, A., Hubenthal, M., Abecasis, G., Zawistowski, M., Skogholt, A. H., Ness-Jensen, E., Hveem, K., Esko, T., Teder-Laving, M., Zhernakova, A., Camilleri, M., Boeckxstaens, G., Whorwell, P. J., Spiller, R., Mcvean, G., D'Amato, M., Jostins, L., and Parkes, M.

Subjects
Male, Molecular Chaperone, Mood Disorder, 631/208/205/2138, Biology, 692/699/1503/1502/2071, Bioinformatics, Polymorphism, Single Nucleotide, Genetic pathways, 38/43, Irritable Bowel Syndrome, Cytoskeletal Protein, Genetics, medicine, Genetic predisposition, Aged, Anxiety Disorders, CD56 Antigen, Cell Adhesion Molecules, Cytoskeletal Proteins, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Guanine Nucleotide Exchange Factors, Homeodomain Proteins, Humans, Middle Aged, Molecular Chaperones, Mood Disorders, United Kingdom, Polymorphism, 692/699/476, Irritable bowel syndrome, Depression (differential diagnoses), article, Homeodomain Protein, Single Nucleotide, Guanine Nucleotide Exchange Factor, medicine.disease, Neuroticism, Biobank, Mood, Cell Adhesion Molecule, Anxiety, medicine.symptom, Anxiety Disorder, Human
Abstract

Funder: Kennedy Trust Rheumatology Research Prize Studentship, Funder: DFG Cluster of Excellence ���Precision Medicine in Chronic In-flammation��� (PMI; ID: EXC2167), Funder: EC | EC Seventh Framework Programm | FP7 Ideas: European Research Council (FP7-IDEAS-ERC - Specific Programme: ���Ideas��� Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013)); doi: https://doi.org/10.13039/100011199; Grant(s): 715772, Funder: NWO-VIDI grant 016.178.056, the Netherlands Heart Foundation CVON grant 2018-27, and NWO Gravitation grant ExposomeNL, Funder: Li Ka Shing Foundation (Li Ka Shing Foundation Limited); doi: https://doi.org/10.13039/100007421, Irritable bowel syndrome (IBS) results from disordered brain���gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS with independent cohorts. We conducted a genome-wide association study with 53,400 cases and 433,201 controls and replicated significant associations in a 23andMe panel (205,252 cases and 1,384,055 controls). Our study identified and confirmed six genetic susceptibility loci for IBS. Implicated genes included NCAM1, CADM2, PHF2/FAM120A, DOCK9, CKAP2/TPTE2P3 and BAG6. The first four are associated with mood and anxiety disorders, expressed in the nervous system, or both. Mirroring this, we also found strong genome-wide correlation between the risk of IBS and anxiety, neuroticism and depression (rg > 0.5). Additional analyses suggested this arises due to shared pathogenic pathways rather than, for example, anxiety causing abdominal symptoms. Implicated mechanisms require further exploration to help understand the altered brain���gut interactions underlying IBS.

Published
2021

43. The Performances of Three Commercially Available Assays for the Detection of SARS-CoV-2 Antibodies at Different Time Points Following SARS-CoV-2 Infection

Author

Syre, Heidi, primary, Obreque, Marius Eduardo Brå, additional, Dalen, Ingvild, additional, Riis, Åse Garløv, additional, Berg, Åse, additional, Löhr, Iren Høyland, additional, Sundal, Jon, additional, Kleppe, Lars Kåre, additional, Vadla, May Sissel, additional, Lenning, Ole Bernt, additional, Olofsson, Jan Stefan, additional, Mohn, Kristin Greve-Isdahl, additional, Tøndel, Camilla, additional, Blomberg, Bjørn, additional, Trieu, Mai Chi, additional, Langeland, Nina, additional, and Cox, Rebecca Jane, additional

Published
2022
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44. Clinical features and risk factors for death in acute undifferentiated fever: A prospective observational study in rural community hospitals in six states of India

Author

Mørch, Kristine, primary, Manoharan, Anand, additional, Chandy, Sara, additional, Singh, Ashita, additional, Kuriakose, Cijoy, additional, Patil, Suvarna, additional, Henry, Anil, additional, Chacko, Novin, additional, Alvarez-Uria, Gerardo, additional, Nesaraj, Joel, additional, Blomberg, Bjørn, additional, Kurian, Siby, additional, Haanshuus, Christel Gill, additional, Antony, George Vasanthan, additional, Langeland, Nina, additional, and Mathai, Dilip, additional

Published
2022
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47. Titers of antibodies the receptor-binding domain (RBD) of ancestral SARS-CoV-2 are predictive for levels of neutralizing antibodies to multiple variants

Author

Lund-Johansen, Fridtjof, primary, Tran, Trung, additional, Vaage, Eline, additional, Mehta, Adi, additional, Chopra, Adity, additional, Kolderup, Anette, additional, Anthi, Aina, additional, König, Marton, additional, Nygaard, Gro, additional, Lind, Andreas, additional, Müller, Fredrik, additional, Nissen-Meyer, Lise, additional, Magnus, Per, additional, Trogstad, Lill-Iren Schou, additional, Mjaaland, Siri, additional, Søraas, Arne, additional, Midtvedt, Karsten, additional, Åsberg, Anders, additional, Barratt-Due, Andreas, additional, Medhus, Asle Wilhelm, additional, Høivik, Marte Lie, additional, Lundin, Knut E. A., additional, Karlsen, Randi, additional, Dahle, Reidun, additional, Danielsson, Karin, additional, Thomassen, Kristine, additional, Kro, Grete Birkeland, additional, Cox, Rebecca, additional, Zhou, Fan, additional, Langeland, Nina, additional, Aukrust, Pål, additional, Melum, Espen, additional, Åvitsland, Tone, additional, Wiencke, Kristine, additional, Holter, Jan, additional, Munthe, Ludvig, additional, Grodeland, Gunnveig, additional, Andersen, Jan, additional, and Vaage, John, additional

Published
2022
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48. Spatiotemporal variation in risk of Shigella infection in childhood: a global risk mapping and prediction model using individual participant data

Author

Badr, Hamada S., primary, Colston, Josh M., additional, Nguyen, Nhat-Lan H., additional, Chen, Yen Ting, additional, Ali, Syed Asad, additional, Rayamajhi, Ajit, additional, Satter, Syed M., additional, Van Trang, Nguyen, additional, Eibach, Daniel, additional, Krumkamp, Ralf, additional, May, Jürgen, additional, Adegnika, Ayola Akim, additional, Prince Manouana, Gédéon, additional, Kremsner, Peter Gottfried, additional, Chilengi, Roma, additional, Hatyoka, Luiza, additional, Debes, Amanda K., additional, Ateudjieu, Jerome, additional, Faruque, Abu S. G., additional, Hossain, M. Jahangir, additional, Kanungo, Suman, additional, Kotloff, Karen L., additional, Mandomando, Inácio, additional, Nisar, M. Imran, additional, Omore, Richard, additional, Sow, Samba O., additional, Zaidi, Anita K. M., additional, Lambrecht, Nathalie, additional, Adu, Bright, additional, Page, Nicola, additional, Platts-Mills, James A., additional, Freitas, Cesar Mavacala, additional, Pelkonen, Tuula, additional, Ashorn, Per, additional, Maleta, Kenneth, additional, Ahmed, Tahmeed, additional, Bessong, Pascal, additional, Bhutta, Zulfiqar A., additional, Mason, Carl, additional, Mduma, Estomih, additional, Olortegui, Maribel P., additional, Yori, Pablo Peñataro, additional, Lima, Aldo A. M., additional, Kang, Gagandeep, additional, Humphrey, Jean, additional, Ntozini, Robert, additional, Prendergast, Andrew J., additional, Okada, Kazuhisa, additional, Wongboot, Warawan, additional, Langeland, Nina, additional, Moyo, Sabrina J., additional, Gaensbauer, James, additional, Melgar, Mario, additional, Freeman, Matthew, additional, Chard, Anna N., additional, Thongpaseuth, Vonethalom, additional, Houpt, Eric, additional, Zaitchik, Benjamin F., additional, and Kosek, Margaret N., additional

Published
2022
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50. A comparison of risk factors for cryptosporidiosis and non-cryptosporidiosis diarrhoea: A case-case-control study in Ethiopian children

Author

Johansen, Øystein Haarklau, primary, Abdissa, Alemseged, additional, Zangenberg, Mike, additional, Mekonnen, Zeleke, additional, Eshetu, Beza, additional, Sharew, Bizuwarek, additional, Moyo, Sabrina, additional, Sommerfelt, Halvor, additional, Langeland, Nina, additional, Robertson, Lucy J., additional, and Hanevik, Kurt, additional

Published
2022
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