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1. The genomic evolutionary dynamics and global circulation patterns of respiratory syncytial virus

Author

Langedijk, Annefleur C., Vrancken, Bram, Lebbink, Robert Jan, Wilkins, Deidre, Kelly, Elizabeth J., Baraldi, Eugenio, Mascareñas de Los Santos, Abiel Homero, Danilenko, Daria M., Choi, Eun Hwa, Palomino, María Angélica, Chi, Hsin, Keller, Christian, Cohen, Robert, Papenburg, Jesse, Pernica, Jeffrey, Greenough, Anne, Richmond, Peter, Martinón-Torres, Federico, Heikkinen, Terho, Stein, Renato T., Hosoya, Mitsuaki, Nunes, Marta C., Verwey, Charl, Evers, Anouk, Kragten-Tabatabaie, Leyla, Suchard, Marc A., Kosakovsky Pond, Sergei L., Poletto, Chiara, Colizza, Vittoria, Lemey, Philippe, and Bont, Louis J.

Published
2024
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4. Nirsevimab binding-site conservation in respiratory syncytial virus fusion glycoprotein worldwide between 1956 and 2021: an analysis of observational study sequencing data

Author

Clement, Pascale, Gupta, Atul, Hashimoto, Koichi, Komissarova, Kseniya, Laubscher, Matt, Lumertz, Magali, Priante, Elena, Rivero-Calle, Irene, Wadia, Ushma, Yun, Ki Wook, Wilkins, Deidre, Langedijk, Annefleur C, Lebbink, Robert Jan, Morehouse, Christopher, Abram, Michael E, Ahani, Bahar, Aksyuk, Anastasia A, Baraldi, Eugenio, Brady, Tyler, Chen, Albert Tian, Chi, Hsin, Choi, Eun Hwa, Cohen, Robert, Danilenko, Daria M, Gopalakrishnan, Vancheswaran, Greenough, Anne, Heikkinen, Terho, Hosoya, Mitsuaki, Keller, Christian, Kelly, Elizabeth J, Kragten-Tabatabaie, Leyla, Martinón-Torres, Federico, de Los Santos, Abiel Homero Mascareñas, Nunes, Marta C, Palomino, María Angélica, Papenburg, Jesse, Pernica, Jeffrey M, Richmond, Peter, Stein, Renato T, Tuffy, Kevin M, Verwey, Charl, Esser, Mark T, Tabor, David E, and Bont, Louis J

Published
2023
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7. Natural variability of TRAIL, IP-10, and CRP in healthy adults - The 'HERACLES' study

Author

Infection & Immunity, Infectieziekten onderzoek1 (Bont), CTM & Statistical consultation, MMB, CTI Bont, Zorg en O&O, Child Health, Langedijk, Annefleur C, Rengerink, Katrien Oude, Harding, Eline, Wensing, Annemarie, van Slooten, Rianne, Israeli, Yael, Rosenberg, Michal, Gottlieb, Tanya, Eden, Eran, Bont, Louis J, Infection & Immunity, Infectieziekten onderzoek1 (Bont), CTM & Statistical consultation, MMB, CTI Bont, Zorg en O&O, Child Health, Langedijk, Annefleur C, Rengerink, Katrien Oude, Harding, Eline, Wensing, Annemarie, van Slooten, Rianne, Israeli, Yael, Rosenberg, Michal, Gottlieb, Tanya, Eden, Eran, and Bont, Louis J

Published
2024

11. The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates

Author

Mazur, Natalie I, Higgins, Deborah, Nunes, Marta C, Melero, José A, Langedijk, Annefleur C, Horsley, Nicole, Buchholz, Ursula J, Openshaw, Peter J, McLellan, Jason S, Englund, Janet A, Mejias, Asuncion, Karron, Ruth A, Simões, Eric AF, Knezevic, Ivana, Ramilo, Octavio, Piedra, Pedro A, Chu, Helen Y, Falsey, Ann R, Nair, Harish, Kragten-Tabatabaie, Leyla, Greenough, Anne, Baraldi, Eugenio, Papadopoulos, Nikolaos G, Vekemans, Johan, Polack, Fernando P, Powell, Mair, Satav, Ashish, Walsh, Edward E, Stein, Renato T, Graham, Barney S, and Bont, Louis J

Published
2018
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12. Global molecular diversity of RSV – the “INFORM RSV” study

Author

Langedijk, Annefleur C., Lebbink, Robert Jan, Naaktgeboren, Christiana, Evers, Anouk, Viveen, Marco C., Greenough, Anne, Heikkinen, Terho, Stein, Renato T., Richmond, Peter, Martinón-Torres, Federico, Nunes, Marta, Hosoya, Mitsuaki, Keller, Christian, Bauck, Monika, Cohen, Robert, Papenburg, Jesse, Pernica, Jeffrey, Hennus, Marije P., Jin, Hong, Tabor, David E., Tovchigrechko, Andrev, Ruzin, Alexey, Abram, Michael E., Wilkins, Deidre, Wildenbeest, Joanne G., Kragten-Tabatabaie, Leyla, Coenjaerts, Frank E. J., Esser, Mark T., and Bont, Louis J.

Published
2020
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13. Nirsevimab binding-site conservation in respiratory syncytial virus fusion glycoprotein worldwide between 1956 and 2021: an analysis of observational study sequencing data

Author

Wilkins, Deidre, primary, Langedijk, Annefleur C, additional, Lebbink, Robert Jan, additional, Morehouse, Christopher, additional, Abram, Michael E, additional, Ahani, Bahar, additional, Aksyuk, Anastasia A, additional, Baraldi, Eugenio, additional, Brady, Tyler, additional, Chen, Albert Tian, additional, Chi, Hsin, additional, Choi, Eun Hwa, additional, Cohen, Robert, additional, Danilenko, Daria M, additional, Gopalakrishnan, Vancheswaran, additional, Greenough, Anne, additional, Heikkinen, Terho, additional, Hosoya, Mitsuaki, additional, Keller, Christian, additional, Kelly, Elizabeth J, additional, Kragten-Tabatabaie, Leyla, additional, Martinón-Torres, Federico, additional, de Los Santos, Abiel Homero Mascareñas, additional, Nunes, Marta C, additional, Palomino, María Angélica, additional, Papenburg, Jesse, additional, Pernica, Jeffrey M, additional, Richmond, Peter, additional, Stein, Renato T, additional, Tuffy, Kevin M, additional, Verwey, Charl, additional, Esser, Mark T, additional, Tabor, David E, additional, Bont, Louis J, additional, Clement, Pascale, additional, Gupta, Atul, additional, Hashimoto, Koichi, additional, Komissarova, Kseniya, additional, Laubscher, Matt, additional, Lumertz, Magali, additional, Priante, Elena, additional, Rivero-Calle, Irene, additional, Wadia, Ushma, additional, and Yun, Ki Wook, additional

Published
2023
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14. Lethal Respiratory Syncytial Virus in Zambia Is Sensitive to Long-acting Monoclonal Antibodies

Author

Infection & Immunity, Infectieziekten onderzoek1 (Bont), MMB Research line 3a, CTI Bont, Child Health, Langedijk, Annefleur C, Vrancken, Bram, Lebbink, Robert Jan, Evers, Anouk, Pieciak, Rachel C, Lemey, Philippe, Bont, Louis J, Gill, Christopher J, Infection & Immunity, Infectieziekten onderzoek1 (Bont), MMB Research line 3a, CTI Bont, Child Health, Langedijk, Annefleur C, Vrancken, Bram, Lebbink, Robert Jan, Evers, Anouk, Pieciak, Rachel C, Lemey, Philippe, Bont, Louis J, and Gill, Christopher J

Published
2023

15. Respiratory syncytial virus infection and novel interventions

Author

Infectieziekten onderzoek1 (Bont), Infection & Immunity, CTI Bont, Child Health, Langedijk, Annefleur C., Bont, Louis J., Infectieziekten onderzoek1 (Bont), Infection & Immunity, CTI Bont, Child Health, Langedijk, Annefleur C., and Bont, Louis J.

Published
2023

16. Nirsevimab binding-site conservation in respiratory syncytial virus fusion glycoprotein worldwide between 1956 and 2021: an analysis of observational study sequencing data

Author

Infectieziekten onderzoek1 (Bont), Infection & Immunity, MMB Research line 3a, CTI Bont, Child Health, Wilkins, Deidre, Langedijk, Annefleur C., Lebbink, Robert Jan, Morehouse, Christopher, Abram, Michael E., Ahani, Bahar, Aksyuk, Anastasia A., Baraldi, Eugenio, Brady, Tyler, Chen, Albert Tian, Chi, Hsin, Choi, Eun Hwa, Cohen, Robert, Danilenko, Daria M., Gopalakrishnan, Vancheswaran, Greenough, Anne, Heikkinen, Terho, Hosoya, Mitsuaki, Keller, Christian, Kelly, Elizabeth J., Kragten-Tabatabaie, Leyla, Martinón-Torres, Federico, de Los Santos, Abiel Homero Mascareñas, Nunes, Marta C., Palomino, María Angélica, Papenburg, Jesse, Pernica, Jeffrey M., Richmond, Peter, Stein, Renato T., Tuffy, Kevin M., Verwey, Charl, Esser, Mark T., Tabor, David E., Bont, Louis J., Clement, Pascale, Gupta, Atul, Hashimoto, Koichi, Komissarova, Kseniya, Laubscher, Matt, Lumertz, Magali, Priante, Elena, Rivero-Calle, Irene, Wadia, Ushma, Yun, Ki Wook, Infectieziekten onderzoek1 (Bont), Infection & Immunity, MMB Research line 3a, CTI Bont, Child Health, Wilkins, Deidre, Langedijk, Annefleur C., Lebbink, Robert Jan, Morehouse, Christopher, Abram, Michael E., Ahani, Bahar, Aksyuk, Anastasia A., Baraldi, Eugenio, Brady, Tyler, Chen, Albert Tian, Chi, Hsin, Choi, Eun Hwa, Cohen, Robert, Danilenko, Daria M., Gopalakrishnan, Vancheswaran, Greenough, Anne, Heikkinen, Terho, Hosoya, Mitsuaki, Keller, Christian, Kelly, Elizabeth J., Kragten-Tabatabaie, Leyla, Martinón-Torres, Federico, de Los Santos, Abiel Homero Mascareñas, Nunes, Marta C., Palomino, María Angélica, Papenburg, Jesse, Pernica, Jeffrey M., Richmond, Peter, Stein, Renato T., Tuffy, Kevin M., Verwey, Charl, Esser, Mark T., Tabor, David E., Bont, Louis J., Clement, Pascale, Gupta, Atul, Hashimoto, Koichi, Komissarova, Kseniya, Laubscher, Matt, Lumertz, Magali, Priante, Elena, Rivero-Calle, Irene, Wadia, Ushma, and Yun, Ki Wook

Published
2023

17. The burden of respiratory syncytial virus in healthy term-born infants in Europe: a prospective birth cohort study

Author

Wildenbeest, Joanne G, primary, Billard, Marie-Noëlle, additional, Zuurbier, Roy P, additional, Korsten, Koos, additional, Langedijk, Annefleur C, additional, van de Ven, Peter M, additional, Snape, Matthew D, additional, Drysdale, Simon B, additional, Pollard, Andrew J, additional, Robinson, Hannah, additional, Heikkinen, Terho, additional, Cunningham, Steve, additional, O'Neill, Thomas, additional, Rizkalla, Bishoy, additional, Dacosta-Urbieta, Ana, additional, Martinón-Torres, Federico, additional, van Houten, Marlies A, additional, Bont, Louis J, additional, Wildenbeest, Joanne, additional, Zuurbier, Roy, additional, van Houten, Marlies, additional, Langedijk, Annefleur, additional, van de Ven, Peter, additional, Bont, Louis, additional, Drysdale, Simon, additional, McGinley, Joseph, additional, Lin, Gu-Lung, additional, Snape, Matthew, additional, Pollard, Andrew, additional, Ives, Andrew, additional, Wolfenden, Helen, additional, Salgia, Sanjay, additional, Shetty, Rohoth, additional, Rivero-Calle, Irene, additional, Gómez-Carballa, Alberto, additional, Pischedda, Sara, additional, Rodriguez-Tenreiro, Carmen, additional, Nair, Harish, additional, Campbell, Harry, additional, Miller, Margaret, additional, Baggott, Julie, additional, Beveridge, Catherine, additional, McKernan, Rachael, additional, Beutels, Philippe, additional, Openshaw, Peter, additional, Meijer, Adam, additional, Kølsen Fischer, Thea, additional, van den Berge, Maarten, additional, Giaquinto, Carlo, additional, Abram, Michael, additional, Swanson, Kena, additional, Aerssens, Jeroen, additional, Vernhes, Charlotte, additional, Gallichan, Scott, additional, Kumar, Veena, additional, and Molero, Eva, additional

Published
2022
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18. A systematic review on global RSV genetic data: Identification of knowledge gaps

Author

Infectieziekten onderzoek1 (Bont), Infectieziekten onderzoek2 (Wildenbeest), MMB Research line 3a, Infection & Immunity, CTI Bont, Child Health, Langedijk, Annefleur C, Harding, Eline R, Konya, Burak, Vrancken, Bram, Lebbink, Robert Jan, Evers, Anouk, Willemsen, Joukje, Lemey, Philippe, Bont, Louis J, Infectieziekten onderzoek1 (Bont), Infectieziekten onderzoek2 (Wildenbeest), MMB Research line 3a, Infection & Immunity, CTI Bont, Child Health, Langedijk, Annefleur C, Harding, Eline R, Konya, Burak, Vrancken, Bram, Lebbink, Robert Jan, Evers, Anouk, Willemsen, Joukje, Lemey, Philippe, and Bont, Louis J

Published
2022

19. The burden of respiratory syncytial virus in healthy term-born infants in Europe: a prospective birth cohort study.

Author

Wildenbeest, Joanne G, Billard, Marie-Noëlle, Zuurbier, Roy P, Korsten, Koos, Langedijk, Annefleur C, van de Ven, Peter M, Snape, Matthew D, Drysdale, Simon B, Pollard, Andrew J, Robinson, Hannah, Heikkinen, Terho, Cunningham, Steve, O'Neill, Thomas, Rizkalla, Bishoy, Dacosta-Urbieta, Ana, Martinón-Torres, Federico, van Houten, Marlies A, and Bont, Louis J

Subjects
RESPIRATORY syncytial virus, RESPIRATORY syncytial virus infections, COHORT analysis, INFANTS, PEDIATRIC intensive care
Abstract

Respiratory syncytial virus (RSV) is a major cause of hospitalisation in infants. The burden of RSV infection in healthy term infants has not yet been established. Accurate health-care burden data in healthy infants are necessary to determine RSV immunisation policy when RSV immunisation becomes available. We performed a multicentre, prospective, observational birth cohort study in healthy term-born infants (≥37 weeks of gestation) in five sites located in different European countries to determine the health-care burden of RSV. The incidence of RSV-associated hospitalisations in the first year of life was determined by parental questionnaires and hospital chart reviews. We performed active RSV surveillance in a nested cohort to determine the incidence of medically attended RSV infections. The study is registered with ClinicalTrials.gov , NCT03627572. In total, 9154 infants born between July 1, 2017, and April 1, 2020, were followed up during the first year of life and 993 participated in the nested active surveillance cohort. The incidence of RSV-associated hospitalisations in the total cohort was 1·8% (95% CI 1·6–2·1). There were eight paediatric intensive care unit admissions, corresponding to 5·5% of 145 RSV-associated hospitalisations and 0·09% of the total cohort. Incidence of RSV infection in the active surveillance cohort confirmed by any diagnostic assay was 26·2% (24·0–28·6) and that of medically attended RSV infection was 14·1% (12·3–16·0). RSV-associated acute respiratory infection causes substantial morbidity, leading to the hospitalisation of one in every 56 healthy term-born infants in high-income settings. Immunisation of pregnant women or healthy term-born infants during their first winter season could have a major effect on the health-care burden caused by RSV infections. Innovative Medicines Initiative 2 Joint Undertaking, with support from the EU's Horizon 2020 research and innovation programme and European Federation of Pharmaceutical Industries and Associations. [ABSTRACT FROM AUTHOR]

Published
2023
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20. Low Sensitivity of BinaxNOW RSV in Infants

Author

Zuurbier, Roy P, Bont, Louis J, Langedijk, Annefleur C, Hamer, Mirjam, Korsten, Koos, Drysdale, Simon B, Snape, Matthew D, Robinson, Hannah, Pollard, Andrew J, Martinón-Torres, Federico, Rodríguez-Tenreiro Sánchez, Carmen, Gómez-Carballa, Alberto, Dacosta-Urbieta, Ana Isabel, Heikkinen, Terho, Cunningham, Steve, van Houten, Marlies A, Wildenbeest, Joanne G, Zuurbier, Roy, Bont, Louis, Langedijk, Annefleur, van Houten, Marlies, Wildenbeest, Joanne, Drysdale, Simon, Snape, Matthew, Pollard, Andrew, Dacosta-Urbieta, Ana, Nair, Harish, Campbell, Harry, Openshaw, Peter, Beutels, Philippe, Molero, Eva, Meijer, Adam, Kølsen Fischer, Thea, van den Berge, Maarten, Giaquinto, Carlo, Esser, Mark, Knirsch, Charles, Leach, Amanda, Gallichan, Scott, Aerssens, Jeroen, Rosen, Brian, and Investigators, RESCEU

Subjects
Male, medicine.medical_specialty, Adolescent, medicine.drug_class, Point-of-Care Systems, Point-of-care testing, Antibiotics, Respiratory Syncytial Virus Infections, Sensitivity and Specificity, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Severity of illness, medicine, Humans, Immunology and Allergy, 030212 general & internal medicine, Pathology, Molecular, Respiratory system, Child, Antigens, Viral, Reference standards, 0303 health sciences, Respiratory tract infections, 030306 microbiology, business.industry, Gold standard (test), Confidence interval, 3. Good health, Hospitalization, Infectious Diseases, Case-Control Studies, Child, Preschool, Respiratory Syncytial Virus, Human, Female, Reagent Kits, Diagnostic, business
Abstract

Background Respiratory syncytial virus (RSV) is a major cause of hospitalization in infants. Early detection of RSV can optimize clinical management and minimize use of antibiotics. BinaxNOW RSV (BN) is a rapid antigen detection test that is widely used. We aimed to validate the sensitivity of BN in hospitalized and nonhospitalized infants against the gold standard of molecular diagnosis. Methods We evaluated the performance of BN in infants with acute respiratory tract infections with different degrees of disease severity. Diagnostic accuracy of BN test results were compared with molecular diagnosis as reference standard. Results One hundred sixty-two respiratory samples from 148 children from October 2017 to February 2019 were studied. Sixty-six (40.7%) samples tested positive for RSV (30 hospitalizations, 31 medically attended episodes not requiring hospitalization, and 5 nonmedically attended episodes). Five of these samples tested positive with BN, leading to an overall sensitivity of BN of 7.6% (95% confidence interval [CI], 3.3%–16.5%) and a specificity of 100% (95% CI, 96.2%–100%). Sensitivity was low in all subgroups. Conclusions We found a low sensitivity of BN for point-of-care detection of RSV infection. BinaxNOW RSV should be used and interpreted with caution.

Published
2020

21. Clinical and Viral Factors Associated With Disease Severity and Subsequent Wheezing in Infants With Respiratory Syncytial Virus Infection

Author

McGinley, Joseph P, Lin, Gu Lung, Öner, Deniz, Golubchik, Tanya, O’Connor, Daniel, Snape, Matthew D, Gruselle, Olivier, Langedijk, Annefleur C, Wildenbeest, Joanne, Openshaw, Peter, Nair, Harish, Aerssens, Jeroen, Bont, Louis, Martinón-Torres, Federico, Drysdale, Simon B, Pollard, Andrew J, Campbell, Harry, Cunningham, Steve, Bogaert, Debby, Beutels, Philippe, Pollard, Andrew, Butler, Christopher, Snape, Matthew, Drysdale, Simon, Lin, Gu-Lung, Clutterbuck, Elizabeth, McGinley, Joseph, Thwaites, Ryan, Wiseman, Dexter, Gómez-Carballa, Alberto, Rodríguez-Tenreiro, Carmen, Rivero-Calle, Irene, Dacosta-Urbieta, Ana, Heikkinen, Terho, Meijer, Adam, Fischer, Thea K, van den Berge, Maarten, Giaquinto, Carlo, Abram, Michael, Myint, Tin Tin, Rizkalla, Bishoy, Vernhes, Charlotte, Gallichan, Scott, Kumar, Veena, Molero, Eva, and Investigators, RESCEU

Subjects
disease severity, respiratory syncytial virus, subgroup, viral load, wheezing, Hospitalization, Humans, Infant, Respiratory Sounds, Severity of Illness Index, Respiratory Syncytial Virus Infections, Respiratory Syncytial Virus, Human, Infectious Diseases, Immunology and Allergy, Human
Abstract

Respiratory syncytial virus (RSV) causes substantial morbidity and mortality in infants and young children worldwide. Here we evaluated host demographic and viral factors associated with RSV disease severity in 325 RSV-infected infants under 1 year of age from 3 European countries during 2017–2020. Younger infants had a higher clinical severity (ReSViNET) score and were more likely to require hospitalization, intensive care, respiratory support, and/or mechanical ventilation than older infants ( Clinical Trials Registration NCT03756766.

Published
2022

24. Long-term Memory Response After a Single Intramuscular Rabies Booster Vaccination 10-24 Years After Primary Immunization.

Author

Pijper, Cornelis A De, Langedijk, Annefleur C, Terryn, Sanne, Gucht, Steven Van, Grobusch, Martin P, Goorhuis, Abraham, Stijnis, Cornelis, De Pijper, Cornelis A, and Van Gucht, Steven

Subjects
*RABIES vaccines, *BOOSTER vaccines, *LONG-term memory, *IMMUNIZATION, *IMMUNOLOGIC memory, *RABIES prevention, *MEMORY, *INTRAMUSCULAR injections, *INTRADERMAL injections, *RNA viruses, *VIRAL antibodies
Abstract

Background: Published data regarding long-lasting immunological rabies memory after pre-exposure prophylaxis (PrEP) are scarce. We tested the hypothesis that rabies booster immunization elicits rapid anamnestic responses.Methods: For this observational study, we included participants who had received PrEP 10-24 years before inclusion. We measured rabies antibody titers before, and on days 3, 7, and 14 after a single intramuscular booster.Results: All 28 participants responded adequately regardless of route of administration or 2-dose vs 3-dose PrEP regimen.Conclusion: Rabies immunological memory is reactivated within 7 days after a single intramuscular booster immunization, even when administered 10-24 years after PrEP. [ABSTRACT FROM AUTHOR]

Published
2022
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26. Global Molecular Epidemiology of Respiratory Syncytial Virus from the 2017-2018 INFORM-RSV Study

Author

Infectieziekten onderzoek1 (Bont), MMB Research line 1, MMB Research line 3a, Infection & Immunity, Facilitair team Zeist, CTI Bont, Infectiezieken, Child Health, Intensive care patientenzorg, Tabor, David E, Fernandes, Fiona, Langedijk, Annefleur C, Wilkins, Deidre, Lebbink, Robert Jan, Tovchigrechko, Andrey, Ruzin, Alexey, Kragten-Tabatabaie, Leyla, Jin, Hong, Esser, Mark T, Bont, Louis J, Abram, Michael E, INFORM-RSV Study Group, Infectieziekten onderzoek1 (Bont), MMB Research line 1, MMB Research line 3a, Infection & Immunity, Facilitair team Zeist, CTI Bont, Infectiezieken, Child Health, Intensive care patientenzorg, Tabor, David E, Fernandes, Fiona, Langedijk, Annefleur C, Wilkins, Deidre, Lebbink, Robert Jan, Tovchigrechko, Andrey, Ruzin, Alexey, Kragten-Tabatabaie, Leyla, Jin, Hong, Esser, Mark T, Bont, Louis J, Abram, Michael E, and INFORM-RSV Study Group

Published
2021

27. Transcriptome of airway neutrophils reveals an interferon response in life-threatening respiratory syncytial virus infection

Author

Arts-assistenten Kinderen, Infectieziekten onderzoek1 (Bont), Intensive care patientenzorg, Infection & Immunity, CTI, Cancer, Electrofysiologie, Onderzoek Precision medicine, Child Health, Circulatory Health, CTI Bont, Infectiezieken, Immuno/reuma onderzoek 5 (Vastert2), Besteman, Sjanna B., Callaghan, Amie, Langedijk, Annefleur C., Hennus, Marije P., Meyaard, Linde, Mokry, Michal, Bont, Louis J., Calis, Jorg J.A., Arts-assistenten Kinderen, Infectieziekten onderzoek1 (Bont), Intensive care patientenzorg, Infection & Immunity, CTI, Cancer, Electrofysiologie, Onderzoek Precision medicine, Child Health, Circulatory Health, CTI Bont, Infectiezieken, Immuno/reuma onderzoek 5 (Vastert2), Besteman, Sjanna B., Callaghan, Amie, Langedijk, Annefleur C., Hennus, Marije P., Meyaard, Linde, Mokry, Michal, Bont, Louis J., and Calis, Jorg J.A.

Published
2020

28. Global molecular diversity of RSV - the 'INFORM RSV' study

Author

Infectieziekten onderzoek1 (Bont), MMB Research line 3a, Infection & Immunity, Epi Methoden Team 1, MMB, Intensive care patientenzorg, DT Panda, Infectieziekten patientenzorg, CTI Bont, Infectiezieken, Child Health, Langedijk, Annefleur C, Lebbink, Robert Jan, Naaktgeboren, Christiana, Evers, Anouk, Viveen, Marco C, Greenough, Anne, Heikkinen, Terho, Stein, Renato T, Richmond, Peter, Martinón-Torres, Federico, Nunes, Marta, Hosoya, Mitsuaki, Keller, Christian, Bauck, Monika, Cohen, Robert, Papenburg, Jesse, Pernica, Jeffrey, Hennus, Marije P, Jin, Hong, Tabor, David E, Tovchigrechko, Andrev, Ruzin, Alexey, Abram, Michael E, Wilkins, Deidre, Wildenbeest, Joanne G, Kragten-Tabatabaie, Leyla, Coenjaerts, Frank E J, Esser, Mark T, Bont, Louis J, Infectieziekten onderzoek1 (Bont), MMB Research line 3a, Infection & Immunity, Epi Methoden Team 1, MMB, Intensive care patientenzorg, DT Panda, Infectieziekten patientenzorg, CTI Bont, Infectiezieken, Child Health, Langedijk, Annefleur C, Lebbink, Robert Jan, Naaktgeboren, Christiana, Evers, Anouk, Viveen, Marco C, Greenough, Anne, Heikkinen, Terho, Stein, Renato T, Richmond, Peter, Martinón-Torres, Federico, Nunes, Marta, Hosoya, Mitsuaki, Keller, Christian, Bauck, Monika, Cohen, Robert, Papenburg, Jesse, Pernica, Jeffrey, Hennus, Marije P, Jin, Hong, Tabor, David E, Tovchigrechko, Andrev, Ruzin, Alexey, Abram, Michael E, Wilkins, Deidre, Wildenbeest, Joanne G, Kragten-Tabatabaie, Leyla, Coenjaerts, Frank E J, Esser, Mark T, and Bont, Louis J

Published
2020

30. A systematic review on global RSV genetic data: Identification of knowledge gaps.

Author

Langedijk, Annefleur C., Harding, Eline R., Konya, Burak, Vrancken, Bram, Lebbink, Robert Jan, Evers, Anouk, Willemsen, Joukje, Lemey, Philippe, and Bont, Louis J.

Abstract

Respiratory syncytial virus (RSV) is a major health problem. A better understanding of the geographical and temporal dynamics of RSV circulation will assist in tracking resistance against therapeutics currently under development. Since 2015, the field of RSV molecular epidemiology has evolved rapidly with around 20–30 published articles per year. The objective of this systematic review is to identify knowledge gaps in recent RSV genetic literature to guide global molecular epidemiology research. We included 78 studies published between 2015 and 2020 describing 12,998 RSV sequences of which 8,233 (63%) have been uploaded to GenBank. Seventeen (22%) studies were performed in low‐ and middle‐income countries (LMICs), and seven (9%) studies sequenced whole‐genomes. Although most reported polymorphisms for monoclonal antibodies in clinical development (nirsevimab, MK‐1654) have not been tested for resistance in neutralisation essays, known resistance was detected at low levels for the nirsevimab and palivizumab binding site. High resistance was found for the suptavumab binding site. We present the first literature review of an enormous amount of RSV genetic data. The need for global monitoring of RSV molecular epidemiology becomes increasingly important in evaluating the effectiveness of monoclonal antibody candidates as they reach their final stages of clinical development. We have identified the following three knowledge gaps: whole‐genome data to study global RSV evolution, data from LMICs and data from global surveillance programs. [ABSTRACT FROM AUTHOR]

Published
2022
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33. The respiratory syncytial virus vaccine landscape : lessons from the graveyard and promising candidates

Author

Mazur, Natalie I., Higgins, Deborah, Nunes, Marta C., Melero, José A., Langedijk, Annefleur C., Horsley, Nicole, Buchholz, Ursula J., Openshaw, Peter J., McLellan, Jason S., Englund, Janet A., Mejias, Asuncion, Karron, Ruth A., Simões, Eric AF, Knezevic, Ivana, Ramilo, Octavio, Piedra, Pedro A., Chu, Helen Y., Falsey, Ann R., Nair, Harish, Kragten-Tabatabaie, Leyla, Greenough, Anne, Baraldi, Eugenio, Papadopoulos, Nikolaos G., Vekemans, Johan, Polack, Fernando P., Powell, Mair, Satav, Ashish, Walsh, Edward E., Stein, Renato T., Graham, Barney S., Bont, Louis J., Respiratory Syncytial Virus Network (ReSViNET) Foundation, Mazur, Natalie I., Higgins, Deborah, Nunes, Marta C., Melero, José A., Langedijk, Annefleur C., Horsley, Nicole, Buchholz, Ursula J., Openshaw, Peter J., McLellan, Jason S., Englund, Janet A., Mejias, Asuncion, Karron, Ruth A., Simões, Eric AF, Knezevic, Ivana, Ramilo, Octavio, Piedra, Pedro A., Chu, Helen Y., Falsey, Ann R., Nair, Harish, Kragten-Tabatabaie, Leyla, Greenough, Anne, Baraldi, Eugenio, Papadopoulos, Nikolaos G., Vekemans, Johan, Polack, Fernando P., Powell, Mair, Satav, Ashish, Walsh, Edward E., Stein, Renato T., Graham, Barney S., Bont, Louis J., and Respiratory Syncytial Virus Network (ReSViNET) Foundation

Published
2018

34. The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates

Author

Infectieziekten onderzoek1 (Bont), Infectiezieken, CTI Bont, Child Health, Infection & Immunity, Mazur, Natalie I., Higgins, Deborah, Nunes, Marta C., Melero, José A., Langedijk, Annefleur C., Horsley, Nicole, Buchholz, Ursula J., Openshaw, Peter J., McLellan, Jason S., Englund, Janet A., Mejias, Asuncion, Karron, Ruth A., Simões, Eric AF, Knezevic, Ivana, Ramilo, Octavio, Piedra, Pedro A., Chu, Helen Y., Falsey, Ann R., Nair, Harish, Kragten-Tabatabaie, Leyla, Greenough, Anne, Baraldi, Eugenio, Papadopoulos, Nikolaos G., Vekemans, Johan, Polack, Fernando P., Powell, Mair, Satav, Ashish, Walsh, Edward E., Stein, Renato T., Graham, Barney S., Bont, Louis J., Respiratory Syncytial Virus Network (ReSViNET) Foundation, Infectieziekten onderzoek1 (Bont), Infectiezieken, CTI Bont, Child Health, Infection & Immunity, Mazur, Natalie I., Higgins, Deborah, Nunes, Marta C., Melero, José A., Langedijk, Annefleur C., Horsley, Nicole, Buchholz, Ursula J., Openshaw, Peter J., McLellan, Jason S., Englund, Janet A., Mejias, Asuncion, Karron, Ruth A., Simões, Eric AF, Knezevic, Ivana, Ramilo, Octavio, Piedra, Pedro A., Chu, Helen Y., Falsey, Ann R., Nair, Harish, Kragten-Tabatabaie, Leyla, Greenough, Anne, Baraldi, Eugenio, Papadopoulos, Nikolaos G., Vekemans, Johan, Polack, Fernando P., Powell, Mair, Satav, Ashish, Walsh, Edward E., Stein, Renato T., Graham, Barney S., Bont, Louis J., and Respiratory Syncytial Virus Network (ReSViNET) Foundation

Published
2018

36. How Viral Sequence Analysis May Guide Development of Respiratory Syncytial Virus Monoclonal Antibodies.

Author

Langedijk, Annefleur C and Bont, Louis J

Subjects
*RESPIRATORY syncytial virus, *SEQUENCE analysis, *GENETIC mutation, *MONOCLONAL antibodies, *RESPIRATORY syncytial virus infections
Abstract

The article discusses How Viral Sequence Analysis May Guide Development of Respiratory Syncytial Virus Monoclonal Antibodies. It mentions proof-of-concept that suptavumab failed directly due to the spontaneous RSV B escape mutant; and also mentions spontaneous mutation may have high impact on antibody binding.

Published
2021
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37. Global Molecular Epidemiology of Respiratory Syncytial Virus from the 2017-2018 INFORM-RSV Study

Author

Tabor, David E., Fernandes, Fiona, Langedijk, Annefleur C., Wilkins, Deidre, Lebbink, Robert Jan, Tovchigrechko, Andrey, Ruzin, Alexey, Kragten-Tabatabaie, Leyla, Jin, Hong, Esser, Mark T., Bont, Louis J., and Abram, Michael E.

Abstract

Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection among infants and young children, resulting in annual epidemics worldwide. INFORM-RSV is a multiyear clinical study designed to describe the global molecular epidemiology of RSV in children under 5 years of age by monitoring temporal and geographical evolution of current circulating RSV strains, F protein antigenic sites, and their relationships with clinical features of RSV disease. During the pilot season (2017–2018), 410 RSV G-F gene sequences were obtained from 476 RSV-positive nasal samples collected from 8 countries (United Kingdom, Spain, The Netherlands, Finland, Japan, Brazil, South Africa, and Australia).

Published
2020
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38. The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates.

Author

Respiratory Syncytial Virus Network (ReSViNET) Foundation, Mazur, Natalie I, Bont, Louis J, Melero, José A, McLellan, Jason S, Englund, Janet A, Karron, Ruth A, Simões, Eric AF, Knezevic, Ivana, Piedra, Pedro A, Langedijk, Annefleur C, Walsh, Edward E, Vekemans, Johan, Higgins, Deborah, Powell, Mair, Satav, Ashish, Graham, Barney S, Nunes, Marta C, Chu, Helen Y, and Ramilo, Octavio

Subjects
*RESPIRATORY syncytial virus, *INFANTS, *GLYCOPROTEINS, *MONOCLONAL antibodies, *VACCINES
Abstract

The global burden of disease caused by respiratory syncytial virus (RSV) is increasingly recognised, not only in infants, but also in older adults (aged ≥65 years). Advances in knowledge of the structural biology of the RSV surface fusion glycoprotein have revolutionised RSV vaccine development by providing a new target for preventive interventions. The RSV vaccine landscape has rapidly expanded to include 19 vaccine candidates and monoclonal antibodies (mAbs) in clinical trials, reflecting the urgency of reducing this global health problem and hence the prioritisation of RSV vaccine development. The candidates include mAbs and vaccines using four approaches: (1) particle-based, (2) live-attenuated or chimeric, (3) subunit, (4) vector-based. Late-phase RSV vaccine trial failures highlight gaps in knowledge regarding immunological protection and provide lessons for future development. In this Review, we highlight promising new approaches for RSV vaccine design and provide a comprehensive overview of RSV vaccine candidates and mAbs in clinical development to prevent one of the most common and severe infectious diseases in young children and older adults worldwide. [ABSTRACT FROM AUTHOR]

Published
2018
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39. Long-term Memory Response After a Single Intramuscular Rabies Booster Vaccination 10-24 Years After Primary Immunization.

Author

De Pijper CA, Langedijk AC, Terryn S, Van Gucht S, Grobusch MP, Goorhuis A, and Stijnis C

Subjects
Antibodies, Viral, Humans, Immunization, Secondary, Injections, Intradermal, Injections, Intramuscular, Memory, Long-Term, Vaccination, Rabies prevention & control, Rabies Vaccines, Rabies virus
Abstract

Background: Published data regarding long-lasting immunological rabies memory after pre-exposure prophylaxis (PrEP) are scarce. We tested the hypothesis that rabies booster immunization elicits rapid anamnestic responses., Methods: For this observational study, we included participants who had received PrEP 10-24 years before inclusion. We measured rabies antibody titers before, and on days 3, 7, and 14 after a single intramuscular booster., Results: All 28 participants responded adequately regardless of route of administration or 2-dose vs 3-dose PrEP regimen., Conclusion: Rabies immunological memory is reactivated within 7 days after a single intramuscular booster immunization, even when administered 10-24 years after PrEP., Competing Interests: Potential conflicts of interest. All authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed., (© The Author(s) 2022. Published by Oxford University Press for the Infectious Diseases Society of America.)

Published
2022
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