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We define symmetries in non-relativistic quantum electrodynamics, which have the physical interpretation of rotation, parity and time reversal symmetry. We collect transformation properties related to these symmetries in Fock space representation as well as in the Schr\"odinger representation. As an application, we generalize and improve theorems about Kramer's degeneracy in non-relativistic quantum electrodynamics., Comment: 40 pages

We consider finite-range, many-body fermionic lattice models and we study the evolution of their thermal equilibrium state after introducing a weak and slowly varying time-dependent perturbation. Under suitable assumptions on the external driving, we derive a representation for the average of the evolution of local observables via a convergent expansion in the perturbation, for small enough temperatures. Convergence holds for a range of parameters that is uniform in the size of the system. Under a spectral gap assumption on the unperturbed Hamiltonian, convergence is also uniform in temperature. As an application, our expansion allows us to prove closeness of the time-evolved state to the instantaneous Gibbs state of the perturbed system, in the sense of expectation of local observables, at zero and at small temperatures. As a corollary, we also establish the validity of linear response. Our strategy is based on a rigorous version of the Wick rotation, which allows us to represent the Duhamel expansion for the real-time dynamics in terms of Euclidean correlation functions, for which precise decay estimates are proved using fermionic cluster expansion., Comment: The introduction and the discussion after the main result have been improved, minor corrections. We added a new corollary, about the stronger adiabatic convergence for switch functions with derivatives vanishing at zero. 61 pages

We consider Hamiltonians of models describing non-relativistic quantum mechanical matter coupled to a relativistic field of bosons. If the free Hamiltonian has an eigenvalue, we show that this eigenvalue persists also for nonzero coupling. The eigenvalue of the free Hamiltonian may be degenerate provided there exists a symmetry group acting irreducibly on the eigenspace. Furthermore, if the Hamiltonian depends analytically on external parameters then so does the eigenvalue and eigenvector. Our result applies to the ground state as well as resonance states. For our results we assume a mild infrared condition. The proof is based on operator theoretic renormalization. It generalizes the method used in [15] to non-degenerate situations, where the degeneracy is protected by a symmetry group, and utilizes Schur's lemma from representation theory., Comment: 53 pages

We present a method to calculate the asymptotic behavior of eigenfunctions of Schr\"odinger operators that also works at the threshold of the essential spectrum. It can be viewed as a higher order correction to the well-known WKB method which does need a safety distance to the essential spectrum. We illustrate its usefulness on examples of quantum particles in a potential well with a long-range repulsive term outside the well., Comment: arXiv admin note: substantial text overlap with arXiv:2012.12748

One of the crucial properties of a quantum system is the existence of bound states. While the existence of eigenvalues below zero, i.e., below the essential spectrum, is well understood, the situation of zero energy bound states at the edge of the essential spectrum is far less understood. We present necessary and sufficient conditions for Schr\"odinger operators to have a zero energy bound state. Our sharp criteria show that the existence and non-existence of zero energy ground states depends strongly on the dimension and the asymptotic behavior of the potential. There is a spectral phase transition with dimension four being critical., Comment: 30 pages

We consider the dynamics $t\mapsto\tau_t$ of an infinite quantum lattice system that is generated by a local interaction. If the interaction decomposes into a finite number of terms that are themselves local interactions, we show that $\tau_t$ can be efficiently approximated by a product of $n$ automorphisms, each of them being an alternating product generated by the individual terms. For any integer $m$, we construct a product formula (in the spirit of Trotter) such that the approximation error scales as $n^{-m}$. Our bounds hold in norm, pointwise for algebra elements that are sufficiently well approximated by finite volume observables., Comment: Published in Annales Henri Poincar\'e

There are several steps to confirming the safety and efficacy of a new medicine. A sequence of trials, each with its own objectives, is usually required. Quantitative risk metrics can be useful for informing decisions about whether a medicine should transition from one stage of development to the next. To obtain an estimate of the probability of regulatory approval, pharmaceutical companies may start with industry-wide success rates and then apply to these subjective adjustments to reflect program-specific information. However, this approach lacks transparency and fails to make full use of data from previous clinical trials. We describe a quantitative Bayesian approach for calculating the probability of success (PoS) at the end of phase II which incorporates internal clinical data from one or more phase IIb studies, industry-wide success rates, and expert opinion or external data if needed. Using an example, we illustrate how PoS can be calculated accounting for differences between the phase IIb data and future phase III trials, and discuss how the methods can be extended to accommodate accelerated drug development pathways., Comment: 22 pages, 9 figures, 3 tables, 45 references

Pharmaceutical companies regularly need to make decisions about drug development programs based on the limited knowledge from early stage clinical trials. In this situation, eliciting the judgements of experts is an attractive approach for synthesising evidence on the unknown quantities of interest. When calculating the probability of success for a drug development program, multiple quantities of interest - such as the effect of a drug on different endpoints - should not be treated as unrelated. We discuss two approaches for establishing a multivariate distribution for several related quantities within the SHeffield ELicitation Framework (SHELF). The first approach elicits experts' judgements about a quantity of interest conditional on knowledge about another one. For the second approach, we first elicit marginal distributions for each quantity of interest. Then, for each pair of quantities, we elicit the concordance probability that both lie on the same side of their respective elicited medians. This allows us to specify a copula to obtain the joint distribution of the quantities of interest. We show how these approaches were used in an elicitation workshop that was performed to assess the probability of success of the registrational program of an asthma drug. The judgements of the experts, which were obtained prior to completion of the pivotal studies, were well aligned with the final trial results., Comment: 29 pages, 7 figures

We give a rigorous argument that long--range repulsion stabilizes quantum systems; ground states of such quantum systems exist even when the ground state energy is precisely at the ionization threshold. For atomic systems at the critical nuclear charge, our bounds show that the ground state falls off like $\exp(-c\sqrt{|x|})$ for large $|x|$. This is much slower than what the WKB method predicts for bound states with energies strictly below the ionization threshold. For helium type systems at critical nuclear charge, we show that our upper bounds are sharp. This rigorously confirms predictions by quantum chemists., Comment: 6+3 pages, 9 figures

In general, linear response theory expresses the relation between a driving and a physical system's response only to first order in perturbation theory. In the context of charge transport, this is the linear relation between current and electromotive force expressed in Ohm's law. We show here that, in the case of the quantum Hall effect, all higher order corrections vanish. We prove this in a fully interacting setting and without flux averaging.

It is well known that $N$-electron atoms undergoes unbinding for a critical charge of the nucleus $Z_c$, i.e. the atom has eigenstates for the case $Z> Z_c$ and it has no bound states for $Z

In the present paper we study two challenging problems for helium-type systems. Existence of eigenvalues at thresholds and the asymptotic behavior of the corresponding eigenfunctions. Since the usual methods for addressing these problems need a safety distance to the essential spectrum, they cannot be applied in critical cases, when an eigenvalue enters the continuum. We develop a method to address both problems and derive sharp upper and lower bounds for the asymptotic behavior of the ground state of critical helium-type systems at the threshold of the essential spectrum. This is the first proof of the precise asymptotic behavior of the ground state for this benchmark problem in quantum chemistry. Moreover, our bounds describe precisely how the asymptotic decay of the ground state changes, when the system becomes critical. In addition, we show the existence of a ground state of this quantum critical system with a finite nuclear mass. Previously this had been known only in the Born-Oppenheimer approximation of infinite nuclear mass.

We consider a Hamilton operator which describes a finite dimensional quantum mechanical system with degenerate eigenvalues coupled to a field of relativistic bosons. We show that the ground state projection and the ground state energy are analytic functions of the coupling constant in a cone with apex at the origin, provided a mild infrared assumption holds. To show the result operator theoretic renormalization is used and extended to degenerate situations., Comment: 47 pages, 1 figure

We consider expansions of eigenvalues and eigenvectors of models of quantum field theory. For a class of models known as generalized spin boson model we prove the existence of asymptotic expansions of the ground state and the ground state energy to arbitrary order. We need a mild but very natural infrared assumption, which is weaker than the assumption usually needed for other methods such as operator theoretic renormalization to be applicable. The result complements previously shown analyticity properties., Comment: 49 pages