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2. Detection of stage I HPV-driven oropharyngeal cancer in asymptomatic individuals in the Hamburg City Health Study using HPV16 E6 serology – A proof-of-concept study

Author

Busch, Chia-Jung, Hoffmann, Anna Sophie, Viarisio, Daniele, Becker, Benjamin T., Rieckmann, Thorsten, Betz, Christian, Bender, Noemi, Schroeder, Lea, Hussein, Yassin, Petersen, Elina, Jagodzinski, Annika, Schäfer, Ines, Burandt, Eike, Lang Kuhs, Krystle, Pawlita, Michael, Waterboer, Tim, and Brenner, Nicole

Published
2022
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4. Summary from an international cancer seminar focused on human papillomavirus (HPV)-positive oropharynx cancer, convened by scientists at IARC and NCI

Author

Kreimer, Aimée R., Chaturvedi, Anil K., Alemany, Laia, Anantharaman, Devasena, Bray, Freddie, Carrington, Mary, Doorbar, John, D'Souza, Gypsyamber, Fakhry, Carole, Ferris, Robert L., Gillison, Maura, Neil Hayes, D., Hildesheim, Allan, Huang, Shao Hui, Kowalski, Luiz P., Lang Kuhs, Krystle A., Lewis, James, Jr, Lowy, Douglas R., Mehanna, Hisham, Ness, Andy, Pawlita, Michael, Pinheiro, Maisa, Schiller, John, Shiels, Meredith S., Tota, Joseph, Mirabello, Lisa, Warnakulasuriya, Saman, Waterboer, Tim, Westra, William, Chanock, Stephen, and Brennan, Paul

Published
2020
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12. Supplemental Table 1 from Human Papillomavirus 16 E6 Antibodies in Individuals without Diagnosed Cancer: A Pooled Analysis

Author

Lang Kuhs, Krystle A., primary, Anantharaman, Devasena, primary, Waterboer, Tim, primary, Johansson, Mattias, primary, Brennan, Paul, primary, Michel, Angelika, primary, Willhauck-Fleckenstein, Martina, primary, Purdue, Mark P., primary, Holcátová, Ivana, primary, Ahrens, Wolfgang, primary, Lagiou, Pagona, primary, Polesel, Jerry, primary, Simonato, Lorenzo, primary, Merletti, Franco, primary, Healy, Claire M., primary, Kjaerheim, Kristina, primary, Conway, David I., primary, Macfarlane, Tatiana V., primary, Thomson, Peter, primary, Castellsagué, Xavier, primary, Znaor, Ariana, primary, Black, Amanda, primary, Huang, Wen-Yi, primary, Krogh, Vittorio, primary, Trichopoulou, Antonia, primary, Bueno-de-Mesquita, H. B(as)., primary, Clavel-Chapelon, Françoise, primary, Weiderpass, Elisabete, primary, Ekström, Johanna, primary, Riboli, Elio, primary, Tjønneland, Anne, primary, Sánchez, María-José, primary, Travis, Ruth C., primary, Hildesheim, Allan, primary, Pawlita, Michael, primary, and Kreimer, Aimée R., primary

Published
2023
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13. Supplemental Tables 1-7 and Methods from Association between Regular Aspirin Use and Circulating Markers of Inflammation: A Study within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

Author

Lang Kuhs, Krystle A., primary, Hildesheim, Allan, primary, Trabert, Britton, primary, Kemp, Troy J., primary, Purdue, Mark P., primary, Wentzensen, Nicolas, primary, Katki, Hormuzd A., primary, Pinto, Ligia A., primary, Loftfield, Erikka, primary, Safaeian, Mahboobeh, primary, Chaturvedi, Anil K., primary, and Shiels, Meredith S., primary

Published
2023
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14. Data from Human Papillomavirus 16 E6 Antibodies in Individuals without Diagnosed Cancer: A Pooled Analysis

Author

Lang Kuhs, Krystle A., primary, Anantharaman, Devasena, primary, Waterboer, Tim, primary, Johansson, Mattias, primary, Brennan, Paul, primary, Michel, Angelika, primary, Willhauck-Fleckenstein, Martina, primary, Purdue, Mark P., primary, Holcátová, Ivana, primary, Ahrens, Wolfgang, primary, Lagiou, Pagona, primary, Polesel, Jerry, primary, Simonato, Lorenzo, primary, Merletti, Franco, primary, Healy, Claire M., primary, Kjaerheim, Kristina, primary, Conway, David I., primary, Macfarlane, Tatiana V., primary, Thomson, Peter, primary, Castellsagué, Xavier, primary, Znaor, Ariana, primary, Black, Amanda, primary, Huang, Wen-Yi, primary, Krogh, Vittorio, primary, Trichopoulou, Antonia, primary, Bueno-de-Mesquita, H. B(as)., primary, Clavel-Chapelon, Françoise, primary, Weiderpass, Elisabete, primary, Ekström, Johanna, primary, Riboli, Elio, primary, Tjønneland, Anne, primary, Sánchez, María-José, primary, Travis, Ruth C., primary, Hildesheim, Allan, primary, Pawlita, Michael, primary, and Kreimer, Aimée R., primary

Published
2023
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21. Image analysis reveals differences in tumor multinucleations in Black and White patients with human papillomavirus‐associated oropharyngeal squamous cell carcinoma

Author

Koyuncu, Can F., primary, Nag, Reetoja, additional, Lu, Cheng, additional, Corredor, Germán, additional, Viswanathan, Vidya S., additional, Sandulache, Vlad C., additional, Fu, Pingfu, additional, Yang, Kailin, additional, Pan, Quintin, additional, Zhang, Zelin, additional, Xu, Jun, additional, Chute, Deborah J., additional, Thorstad, Wade L., additional, Faraji, Farhoud, additional, Bishop, Justin A., additional, Mehrad, Mitra, additional, Castro, Patricia D., additional, Sikora, Andrew G., additional, Thompson, Lester D.R., additional, Chernock, Rebecca D., additional, Lang Kuhs, Krystle A., additional, Wasman, Jay K., additional, Luo, Jingqin R., additional, Adelstein, David J., additional, Koyfman, Shlomo A., additional, Lewis Jr, James S., additional, and Madabhushi, Anant, additional

Published
2022
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24. Effect of Different Human Papillomavirus Serological and DNA Criteria on Vaccine Efficacy Estimates

Author

Lang Kuhs, Krystle A., Porras, Carolina, Schiller, John T., Rodriguez, Ana Cecilia, Schiffman, Mark, Gonzalez, Paula, Wacholder, Sholom, Ghosh, Arpita, Li, Yan, Lowy, Douglas R., Kreimer, Aimée R., Poncelet, Sylviane, Schussler, John, Quint, Wim, van Doorn, Leen-Jan, Sherman, Mark E., Sidawy, Mary, Herrero, Rolando, Hildesheim, Allan, Safaeian, Mahboobeh, Lang Kuhs, Krystle A., Schiller, John T., Schiffman, Mark, Wacholder, Sholom, Lowy, Douglas R., Kreimer, Aimée R., Sherman, Mark E., Hildesheim, Allan, Safaeian, Mahboobeh, Porras, Carolina, Rodriguez, Ana Cecilia, Gonzalez, Paula, Herrero, Rolando, Gonzalez, Paula, Herrero, Rolando, Ghosh, Arpita, Li, Yan, Poncelet, Sylviane, Schussler, John, Quint, Wim, van Doorn, Leen-Jan, Sidawy, Mary, Self, Steve, Benavides, Adriana, Calzada, Luis Diego, Karron, Ruth, Nayar, Ritu, Roach, Nancy, Cain, Joanna, Davey, Diane, DeMets, David, Fuster, Francisco, Gershon, Ann, Holly, Elizabeth, Raventós, Henriette, Rida, Wasima, Rosero-Bixby, Luis, Suthers, Kristen, Lara, Silvia, Thomas, Sarah, Alfaro, Mario, Barrantes, Manuel, Concepción Bratti, M., Cárdenas, Fernando, Cortés, Bernal, Espinoza, Albert, Estrada, Yenory, González, Paula, Guillén, Diego, Herrero, Roland, Jiménez, Silvia E., Morales, Jorge, Villegas, Luis, Morera, Lidia Ana, Pérez, Elmer, Porras, Carolina, Rodríguez, Ana Cecilia, Rivas, Libia, Freer, Enrique, Bonilla, José, García-Piñeres, Alfanso, Silva, Sandra, Atmella, Ivannia, Ramírez, Margarita, Hildesheim, Allan, Kreimer, Aimée R., Lowy, Douglas R., Macklin, Nora, Schiffman, Mark, Schiller, John T., Sherman, Mark, Solomon, Diane, Wacholder, Sholom, Pinto, Ligia, Kemp, Troy, Eklund, Claire, Hutchinson, Martha, Sidawy, Mary, Quint, Wim, and van Doorn, Leen-Jan

Published
2014
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28. Computerized tumor multinucleation index (MuNI) is prognostic in p16+ oropharyngeal carcinoma

Author

Koyuncu, Can F., primary, Lu, Cheng, additional, Bera, Kaustav, additional, Zhang, Zelin, additional, Xu, Jun, additional, Toro, Paula, additional, Corredor, German, additional, Chute, Deborah, additional, Fu, Pingfu, additional, Thorstad, Wade L., additional, Faraji, F., additional, Bishop, Justin A., additional, Mehrad, Mitra, additional, Castro, Patricia D., additional, Sikora, Andrew G., additional, Thompson, Lester D.R., additional, Chernock, R.D., additional, Lang Kuhs, Krystle A., additional, Luo, Jingqin, additional, Sandulache, Vlad, additional, Adelstein, David J., additional, Koyfman, Shlomo, additional, Lewis, James S., additional, and Madabhushi, Anant, additional

Published
2021
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29. Oropharyngeal Squamous Cell Carcinoma Morphology and Subtypes by Human Papillomavirus Type and by 16 Lineages and Sublineages

Author

Lewis, James S., primary, Mirabello, Lisa, additional, Liu, Ping, additional, Wang, Xiaowei, additional, Dupont, William D., additional, Plummer, W. Dale, additional, Pinheiro, Maisa, additional, Yeager, Meredith, additional, Boland, Joseph F., additional, Cullen, Michael, additional, Steinberg, Mia, additional, Bass, Sara, additional, Mehrad, Mitra, additional, O’Boyle, Connor, additional, Lin, Maoxuan, additional, Faden, Daniel L., additional, and Lang-Kuhs, Krystle A., additional

Published
2021
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30. Oropharyngeal Squamous Cell Carcinoma With Discordant p16 and HPV mRNA Results

Author

Shinn, Justin R., primary, Davis, Seth J., additional, Lang-Kuhs, Krystle A., additional, Rohde, Sarah, additional, Wang, Xiaowei, additional, Liu, Ping, additional, Dupont, William D., additional, Plummer, Dale, additional, Thorstad, Wade L., additional, Chernock, Rebecca D., additional, Mehrad, Mitra, additional, and Lewis, James S., additional

Published
2021
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32. The mutational landscape of early‐ and typical‐onset oral tongue squamous cell carcinoma

Author

Campbell, Benjamin R., primary, Chen, Zhishan, additional, Faden, Daniel L., additional, Agrawal, Nishant, additional, Li, Ryan J., additional, Hanna, Glenn J., additional, Iyer, N. Gopalakrishna, additional, Boot, Arnoud, additional, Rozen, Steven G., additional, Vettore, Andre L., additional, Panda, Binay, additional, Krishnan, Neeraja M., additional, Pickering, Curtis R., additional, Myers, Jeffrey N., additional, Guo, Xingyi, additional, and Lang Kuhs, Krystle A., additional

Published
2020
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34. Transcervical sonography and human papillomavirus 16 E6 antibodies are sensitive for the detection of oropharyngeal cancer

Author

Lang Kuhs, Krystle A., primary, Wood, C. Burton, additional, Wiggleton, Jamie, additional, Aulino, Joseph M., additional, Latimer, Brian, additional, Smith, Derek K., additional, Bender, Noemi, additional, Rohde, Sarah, additional, Mannion, Kyle, additional, Kim, Young, additional, Sinard, Robert, additional, Langerman, Alexander, additional, Fleischer, Arthur, additional, Fakhry, Carole, additional, Waterboer, Tim, additional, and Netterville, James L., additional

Published
2020
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35. Impact of human papillomavirus on the tumor microenvironment in oropharyngeal squamous cell carcinoma.

Author

Liu, Xinyi, Liu, Ping, Chernock, Rebecca D., Lang Kuhs, Krystle A., Lewis, James S., Li, Hua, Gay, Hiram A., Thorstad, Wade L., and Wang, Xiaowei

Subjects
SQUAMOUS cell carcinoma, TUMOR microenvironment, IMMUNE checkpoint proteins, DRUG target, PAPILLOMAVIRUSES
Abstract

Increasing evidence has elucidated the clinicopathological significance of tumor microenvironment (TME) cells. However, TME differences associated with human papillomavirus (HPV) infection in oropharyngeal squamous cell carcinoma (OPSCC) have not been well characterized. In our study, we comprehensively determined the TME infiltration patterns in 315 OPSCC patients, and systematically correlated the TME phenotypes with genomic characteristics and clinical features of OPSCCs. In this way, we observed the enrichment of high endothelial cells and adaptive immune cells in HPV‐positive (HPV+) OPSCCs, in contrast to the enrichment of fibroblasts and capillary endothelial cells in HPV− negative (HPV−) OPSCCs. By focusing on immune checkpoint genes, we constructed a coexpression network using genes that were differentially expressed between HPV+ and HPV− OPSCCs. Functional analysis of the network indicated that HPV+ OPSCCs had elevated immune activities by promoting adaptive immune response and suppressing activities related to extracellular matrix organization. Subsequently, clinical analysis showed that identified TME‐relevant genes were closely associated with the prognosis and therapy response in OPSCC. Importantly, results from the TME analysis were further validated using an independent OPSCC cohort. What's new? The tumor microenvironment has become increasingly important in understanding the molecular and clinical behavior of malignant tumors. Might the presence of an oncogenic virus further change the tumor microenvironment? In this study, the authors used RNA‐seq profiling to identify cell types and immune‐checkpoint gene expression that differed between HPV‐positive vs. HPV‐negative oropharyngeal squamous cell carcinomas (OPSCC). These results may provide new therapeutic targets for OPSCC treatment. [ABSTRACT FROM AUTHOR]

Published
2022
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36. A MicroRNA Expression Signature as Prognostic Marker for Oropharyngeal Squamous Cell Carcinoma.

Author

Liu, Xinyi, Liu, Ping, Chernock, Rebecca D, Yang, Zhenming, Kuhs, Krystle A Lang, Lewis, James S., Luo, Jingqin, Li, Hua, Gay, Hiram A, Thorstad, Wade L, Wang, Xiaowei, and Lang Kuhs, Krystle A

Subjects
SQUAMOUS cell carcinoma, OVERALL survival, MICRORNA, REGRESSION analysis, FORECASTING, CERVICAL intraepithelial neoplasia, OROPHARYNGEAL cancer, HEAD & neck cancer, RNA, PROGNOSIS, RESEARCH funding, PROPORTIONAL hazards models
Abstract

Background: Improved prognostication of oropharyngeal squamous cell carcinoma (OPSCC) may facilitate individualized patient management. The goal of this study was to develop and validate a prognostic signature based on microRNA sequencing (miRNA-seq) analysis.Methods: We collected tumor specimens for miRNA-seq analysis from OPSCC patients treated at Washington University in St Louis (n = 324) and Vanderbilt University (n = 130). OPSCC patients (n = 79) from The Cancer Genome Atlas Program were also included for independent validation. Univariate and multivariable Cox regression analyses were performed to identify miRNAs associated with disease outcomes. All statistical tests were 2-sided.Results: By miRNA-seq profiling analysis, we identified a 26-miRNA signature. Based on computed risk scores of the signature, we classified the patients into low- and high-risk groups. In the training cohort, the high-risk group had much shorter overall survival compared with the low-risk group (hazard ratio [HR] = 3.80, 95% confidence interval [CI] = 2.37 to 6.10, P < .001). Subgroup analysis further revealed that the signature was prognostic for HPV-positive OPSCCs (HR = 3.07, 95% CI = 1.65 to 5.71, P < .001). Multivariable analysis indicated that the signature was independent of common clinicopathologic factors for OPSCCs. Importantly, the miRNA signature was a statistically significant predictor of overall survival in independent validation cohorts (The Cancer Genome Atlas Program cohort: HR = 6.05, 95% CI = 2.10 to 17.37, P < .001; Vanderbilt cohort: HR = 7.98, 95% CI = 3.99 to 15.97, P < .001; Vanderbilt HPV-positive cohort: HR = 8.71, 95% CI = 2.70 to 28.14, P < .001).Conclusions: The miRNA signature is a robust and independent prognostic tool for risk stratification of OPSCCs including HPV-positive OPSCCs. [ABSTRACT FROM AUTHOR]

Published
2021
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38. Early onset oral tongue squamous cell carcinoma: Associated factors and patient outcomes

Author

Campbell, Benjamin R., primary, Sanders, Courtney B., additional, Netterville, James L., additional, Sinard, Robert J., additional, Rohde, Sarah L., additional, Langerman, Alexander, additional, Mannion, Kyle, additional, Kim, Young J., additional, Murphy, Barbara A., additional, Lewis, James S., additional, Warner, Jeremy L., additional, Smith, Derek K., additional, and Lang Kuhs, Krystle A., additional

Published
2019
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39. The mutational landscape of early‐ and typical‐onset oral tongue squamous cell carcinoma.

Author

Campbell, Benjamin R., Chen, Zhishan, Faden, Daniel L., Agrawal, Nishant, Li, Ryan J., Hanna, Glenn J., Iyer, N. Gopalakrishna, Boot, Arnoud, Rozen, Steven G., Vettore, Andre L., Panda, Binay, Krishnan, Neeraja M., Pickering, Curtis R., Myers, Jeffrey N., Guo, Xingyi, and Lang Kuhs, Krystle A.

Subjects
TONGUE cancer, SQUAMOUS cell carcinoma, CANCER genes, GENETIC code, GENES, ORAL cancer
Abstract

Background: The incidence of oral tongue squamous cell carcinoma (OTSCC) is increasing among younger birth cohorts. The etiology of early‐onset OTSCC (diagnosed before the age of 50 years) and cancer driver genes remain largely unknown. Methods: The Sequencing Consortium of Oral Tongue Cancer was established through the pooling of somatic mutation data of oral tongue cancer specimens (n = 227 [107 early‐onset cases]) from 7 studies and The Cancer Genome Atlas. Somatic mutations at microsatellite loci and Catalog of Somatic Mutations in Cancer mutation signatures were identified. Cancer driver genes were identified with the MutSigCV and WITER algorithms. Mutation comparisons between early‐ and typical‐onset OTSCC were evaluated via linear regression with adjustments for patient‐related factors. Results: Two novel driver genes (ATXN1 and CDC42EP1) and 5 previously reported driver genes (TP53, CDKN2A, CASP8, NOTCH1, and FAT1) were identified. Six recurrent mutations were identified, with 4 occurring in TP53. Early‐onset OTSCC had significantly fewer nonsilent mutations even after adjustments for tobacco use. No associations of microsatellite locus mutations and mutation signatures with the age of OTSCC onset were observed. Conclusions: This international, multicenter consortium is the largest study to characterize the somatic mutational landscape of OTSCC and the first to suggest differences by age of onset. This study validates multiple previously identified OTSCC driver genes and proposes 2 novel cancer driver genes. In analyses by age, early‐onset OTSCC had a significantly smaller somatic mutational burden that was not explained by differences in tobacco use. Lay Summary: This study identifies 7 specific areas in the human genetic code that could be responsible for promoting the development of tongue cancer.Tongue cancer in young patients (under the age of 50 years) has fewer overall changes to the genetic code in comparison with tongue cancer in older patients, but the authors do not think that this is due to differences in smoking rates between the 2 groups.The cause of increasing cases of tongue cancer in young patients remains unclear. This study identifies 7 putative oral tongue squamous cell carcinoma driver genes (TP53, CDKN2A, CASP8, NOTCH1, FAT1, ATXN1, and CDC42EP1) and shows that early‐onset oral tongue squamous cell carcinoma has a significantly smaller somatic mutational burden that is not explained by differences in tobacco use. [ABSTRACT FROM AUTHOR]

Published
2021
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40. T cell receptor repertoire among women who cleared and failed to clear cervical human papillomavirus infection: An exploratory proof-of-principle study

Author

Lang Kuhs, Krystle A., primary, Lin, Shih-Wen, additional, Hua, Xing, additional, Schiffman, Mark, additional, Burk, Robert D., additional, Rodriguez, Ana Cecilia, additional, Herrero, Rolando, additional, Abnet, Christian C., additional, Freedman, Neal D., additional, Pinto, Ligia A., additional, Hamm, David, additional, Robins, Harlan, additional, Hildesheim, Allan, additional, Shi, Jianxin, additional, and Safaeian, Mahboobeh, additional

Published
2018
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41. Associations between self-reported diabetes and 78 circulating markers of inflammation, immunity, and metabolism among adults in the United States

Author

Van Dyke, Alison L., primary, Lang Kuhs, Krystle A., additional, Shiels, Meredith S., additional, Koshiol, Jill, additional, Trabert, Britton, additional, Loftfield, Erikka, additional, Purdue, Mark P., additional, Wentzensen, Nicolas, additional, Pfeiffer, Ruth M., additional, Katki, Hormuzd A., additional, Hildesheim, Allan, additional, Kemp, Troy J., additional, Pinto, Ligia A., additional, Chaturvedi, Anil K., additional, and Safaeian, Mahboobeh, additional

Published
2017
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42. The Natural History of Oral Human Papillomavirus in Young Costa Rican Women

Author

Beachler, Daniel C., primary, Lang Kuhs, Krystle A., additional, Struijk, Linda, additional, Schussler, John, additional, Herrero, Rolando, additional, Porras, Carolina, additional, Hildesheim, Allan, additional, Cortes, Bernal, additional, Sampson, Joshua, additional, Quint, Wim, additional, Gonzalez, Paula, additional, and Kreimer, Aimée R., additional

Published
2017
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43. Kinetics of the Human Papillomavirus Type 16 E6 Antibody Response Prior to Oropharyngeal Cancer

Author

Kreimer, Aimée R., primary, Johansson, Mattias, additional, Yanik, Elizabeth L., additional, Katki, Hormuzd A., additional, Check, David P., additional, Lang Kuhs, Krystle A., additional, Willhauck-Fleckenstein, Martina, additional, Holzinger, Dana, additional, Hildesheim, Allan, additional, Pfeiffer, Ruth, additional, Williams, Craig, additional, Freedman, Neal D., additional, Huang, Wen-Yi, additional, Purdue, Mark P., additional, Michel, Angelika, additional, Pawlita, Michael, additional, Brennan, Paul, additional, and Waterboer, Tim, additional

Published
2017
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46. Human Papillomavirus 16 E6 Antibodies in Individuals without Diagnosed Cancer : A Pooled Analysis

Author

Lang Kuhs, Krystle A, Anantharaman, Devasena, Waterboer, Tim, Johansson, Mattias, Brennan, Paul, Michel, Angelika, Willhauck-Fleckenstein, Martina, Purdue, Mark P, Holcátová, Ivana, Ahrens, Wolfgang, Lagiou, Pagona, Polesel, Jerry, Simonato, Lorenzo, Merletti, Franco, Healy, Claire M, Kjaerheim, Kristina, Conway, David I, Macfarlane, Tatiana V, Thomson, Peter, Castellsagué, Xavier, Znaor, Ariana, Black, Amanda, Huang, Wen-Yi, Krogh, Vittorio, Trichopoulou, Antonia, Bueno-de-Mesquita, H B As, Clavel-Chapelon, Françoise, Weiderpass, Elisabete, Ekström, Johanna, Riboli, Elio, Tjønneland, Anne, Sánchez, María-José, Travis, Ruth C, Hildesheim, Allan, Pawlita, Michael, Kreimer, Aimée R, Lang Kuhs, Krystle A, Anantharaman, Devasena, Waterboer, Tim, Johansson, Mattias, Brennan, Paul, Michel, Angelika, Willhauck-Fleckenstein, Martina, Purdue, Mark P, Holcátová, Ivana, Ahrens, Wolfgang, Lagiou, Pagona, Polesel, Jerry, Simonato, Lorenzo, Merletti, Franco, Healy, Claire M, Kjaerheim, Kristina, Conway, David I, Macfarlane, Tatiana V, Thomson, Peter, Castellsagué, Xavier, Znaor, Ariana, Black, Amanda, Huang, Wen-Yi, Krogh, Vittorio, Trichopoulou, Antonia, Bueno-de-Mesquita, H B As, Clavel-Chapelon, Françoise, Weiderpass, Elisabete, Ekström, Johanna, Riboli, Elio, Tjønneland, Anne, Sánchez, María-José, Travis, Ruth C, Hildesheim, Allan, Pawlita, Michael, and Kreimer, Aimée R

Abstract

BACKGROUND: The increasing incidence of oropharyngeal cancer in many developed countries has been attributed to human papillomavirus type 16 (HPV16) infections. Recently, HPV16 E6 serology has been identified as a promising early marker for oropharyngeal cancer. Therefore, characterization of HPV16 E6 seropositivity among individuals without cancer is warranted. METHODS: A total of 4,666 controls were pooled from several studies of cancer and HPV seropositivity, all tested within the same laboratory. HPV16 E6 seropositive controls were classified as having (i) moderate [mean fluorescent intensity (MFI) ≥ 484 and <1,000] or (ii) high seroreactivity (MFI ≥ 1,000). Associations of moderate and high HPV16 E6 seroreactivity with (i) demographic risk factors; and seropositivity for (ii) other HPV16 proteins (E1, E2, E4, E7, and L1), and (iii) E6 proteins from non-HPV16 types (HPV6, 11, 18, 31, 33, 45, and 52) were evaluated. RESULTS: Thirty-two (0.7%) HPV16 E6 seropositive controls were identified; 17 (0.4%) with moderate and 15 (0.3%) with high seroreactivity. High HPV16 E6 seroreactivity was associated with former smoking [odds ratio (OR), 5.5; 95% confidence interval (CI), 1.2-51.8], and seropositivity against HPV16 L1 (OR, 4.8; 95% CI, 1.3-15.4); E2 (OR, 7.7; 95% CI, 1.4-29.1); multiple HPV16 proteins (OR, 25.3; 95% CI, 2.6-119.6 for three HPV16 proteins beside E6) and HPV33 E6 (OR, 17.7; 95% CI, 1.9-81.8). No associations were observed with moderate HPV16 E6 seroreactivity. CONCLUSIONS: High HPV16 E6 seroreactivity is rare among individuals without diagnosed cancer and was not explained by demographic factors. IMPACT: Some HPV16 E6 seropositive individuals without diagnosed HPV-driven cancer, especially those with seropositivity against other HPV16 proteins, may harbor a biologically relevant HPV16 infection.

Published
2015
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48. Interferon Lambda 4 Genotype Is Not Associated with Recurrence of Oral or Genital Herpes

Author

Lang Kuhs, Krystle A., primary, Kuniholm, Mark H., additional, Pfeiffer, Ruth M., additional, Chen, Sabrina, additional, Desai, Seema, additional, Edlin, Brian R., additional, Peters, Marion G., additional, Plankey, Michael, additional, Sharp, Gerald B., additional, Strickler, Howard D., additional, Villacres, Maria C., additional, Quinn, Thomas C., additional, Gange, Stephen J., additional, Prokunina-Olsson, Ludmila, additional, Greenblatt, Ruth M., additional, and O’Brien, Thomas R., additional

Published
2015
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49. Abstract 2926: DR5-targeting sensitizes Lgr5+ stem cells to p53 and Chk2-dependent chemotherapy-induced cell death and produces dose-limiting gastrointestinal toxicity (GIT)

Author

Finnberg, Niklas K., primary, Gokare, Prashanth, additional, Navaraj, Arunasalam, additional, Lang Kuhs, Krystle A., additional, Cerniglia, George, additional, Yagita, Hideo, additional, Takeda, Kazuyoshi, additional, Motoyama, Noboru, additional, and El-Deiry, Wafik S., additional

Published
2015
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50. Association between Regular Aspirin Use and Circulating Markers of Inflammation: A Study within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

Author

Lang Kuhs, Krystle A., primary, Hildesheim, Allan, additional, Trabert, Britton, additional, Kemp, Troy J., additional, Purdue, Mark P., additional, Wentzensen, Nicolas, additional, Katki, Hormuzd A., additional, Pinto, Ligia A., additional, Loftfield, Erikka, additional, Safaeian, Mahboobeh, additional, Chaturvedi, Anil K., additional, and Shiels, Meredith S., additional

Published
2015
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