Search

Your search keyword '"Lanfredi, Mariangela"' showing total 162 results
Start Over Author "Lanfredi, Mariangela"
162 results on '"Lanfredi, Mariangela"'

6. The association of childhood trauma, lifetime stressful events and general psychopathological symptoms in euthymic bipolar patients and healthy subjects

Author

Pedrini, Laura, Ferrari, Clarissa, Lanfredi, Mariangela, Bellani, Marcella, Porcelli, Stefano, Caletti, Elisabetta, Sala, Michela, Rossetti, Maria Gloria, Piccin, Sara, Dusi, Nicola, Balestrieri, Matteo, Perlini, Cinzia, Lazzaretti, Matteo, Mandolini, Gian Mario, Pigoni, Alessandro, Boscutti, Andrea, Bonivento, Carolina, Serretti, Alessandro, Rossi, Roberta, and Brambilla, Paolo

Published
2021
Full Text
View/download PDF

11. The EADC‐ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: Evidence of validity

Author

Frisoni, Giovanni B, Jack, Clifford R, Bocchetta, Martina, Bauer, Corinna, Frederiksen, Kristian S, Liu, Yawu, Preboske, Gregory, Swihart, Tim, Blair, Melanie, Cavedo, Enrica, Grothe, Michel J, Lanfredi, Mariangela, Martinez, Oliver, Nishikawa, Masami, Portegies, Marileen, Stoub, Travis, Ward, Chadwich, Apostolova, Liana G, Ganzola, Rossana, Wolf, Dominik, Barkhof, Frederik, Bartzokis, George, DeCarli, Charles, Csernansky, John G, deToledo‐Morrell, Leyla, Geerlings, Mirjam I, Kaye, Jeffrey, Killiany, Ronald J, Lehéricy, Stephane, Matsuda, Hiroshi, O'Brien, John, Silbert, Lisa C, Scheltens, Philip, Soininen, Hilkka, Teipel, Stefan, Waldemar, Gunhild, Fellgiebel, Andreas, Barnes, Josephine, Firbank, Michael, Gerritsen, Lotte, Henneman, Wouter, Malykhin, Nikolai, Pruessner, Jens C, Wang, Lei, Watson, Craig, Wolf, Henrike, deLeon, Mony, Pantel, Johannes, Ferrari, Clarissa, Bosco, Paolo, Pasqualetti, Patrizio, Duchesne, Simon, Duvernoy, Henri, Boccardi, Marina, Initiative, EADC‐ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Volumetry and for the Alzheimer's Disease Neuroimaging, Albert, Marilyn S, Bennet, David, Camicioli, Richard, Collins, D Louis, Dubois, Bruno, Hampel, Harald, denHeijer, Tom, Hock, Christofer, Jagust, William, Launer, Leonore, Maller, Jerome J, Mueller, Susan, Sachdev, Perminder, Simmons, Andy, Thompson, Paul M, Visser, Peter‐Jelle, Wahlund, Lars‐Olof, Weiner, Michael W, and Winblad, Bengt

Subjects
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Biomedical Imaging, Neurodegenerative, Clinical Research, Brain Disorders, Acquired Cognitive Impairment, Bioengineering, Aged, Alzheimer Disease, Atrophy, Female, Functional Laterality, Hippocampus, Humans, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Internet, Magnetic Resonance Imaging, Male, Middle Aged, Neuroimaging, Organ Size, Reproducibility of Results, Hippocampal volumetry, Magnetic resonance, Alzheimer's disease, Biomarkers, Diagnostic criteria, Enrichment, Clinical trials, Validation, Harmonized protocol, Standard operating procedures, Manual segmentation, EADC-ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Volumetry and for the Alzheimer's Disease Neuroimaging Initiative, Geriatrics, Clinical sciences, Biological psychology
Abstract

BackgroundAn international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of the hippocampus on MR. The aim of this study is to study the concurrent validity of the HarP toward local protocols, and its major sources of variance.MethodsFourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative (ADNI) cases scanned at 1.5 T and 3T following local protocols, qualified for segmentation based on the HarP through a standard web-platform and resegmented following the HarP. The five most accurate tracers followed the HarP to segment 15 ADNI cases acquired at three time points on both 1.5 T and 3T.ResultsThe agreement among tracers was relatively low with the local protocols (absolute left/right ICC 0.44/0.43) and much higher with the HarP (absolute left/right ICC 0.88/0.89). On the larger set of 15 cases, the HarP agreement within (left/right ICC range: 0.94/0.95 to 0.99/0.99) and among tracers (left/right ICC range: 0.89/0.90) was very high. The volume variance due to different tracers was 0.9% of the total, comparing favorably to variance due to scanner manufacturer (1.2), atrophy rates (3.5), hemispheric asymmetry (3.7), field strength (4.4), and significantly smaller than the variance due to atrophy (33.5%, P < .001), and physiological variability (49.2%, P < .001).ConclusionsThe HarP has high measurement stability compared with local segmentation protocols, and good reproducibility within and among human tracers. Hippocampi segmented with the HarP can be used as a reference for the qualification of human tracers and automated segmentation algorithms.

Published
2015

14. [Validation of the Italian version of the DISCUS (DISC-Ultra Short), a brief standardized scale for assessing experienced discrimination among people with mental disorders.]

Author

Lasalvia, Antonio, Ingrosso, Nicoletta, Fiorillo, Andrea, Sampogna, Gaia, Lanfredi, Mariangela, Rossi, Roberta, Evans-Lacko, Sara, Bakolis, Ioannis, Rüsch, Nicolas, Bonetto, Chiara, Lasalvia, Antonio, Ingrosso, Nicoletta, Fiorillo, Andrea, Sampogna, Gaia, Lanfredi, Mariangela, Rossi, Roberta, Evans-Lacko, Sara, Bakolis, Ioanni, Rüsch, Nicola, and Bonetto, Chiara

Abstract

Aim: To evaluate the psychometric properties of the DISCUS (DISC-Ultra Short), a measure which assesses experienced discrimination among persons with mental disorders. Methods: Data collected in the three Italian sites (Brescia, Napoli, and Verona) participating at the international project INDIGO-DISCUS. Each Italian site recruited a sample of 50 individuals. Participants were evaluated with the DISCUS. This study evaluated: (a) reliability (internal consistency), (b) validity (convergent and divergent), (c) precision, and (d) acceptability. Participants were also asked to complete three additional measures: Stigma Consciousness, Brief Stigma Coping/Stigma Stress, and Internalized Stigma of Mental Illness (ISMI-10). Results: Overall, 149 people participated; 55% were males, with mean age of 48 (±12.4) years and on average participants had 12 (±3.4) years of education; only 23% were employed. Internal consistency was found to be good (Cronbach α=0.79). Convergent validity was confirmed (all correlations between DISCUS score and the other measures' scores were greater than 0.30). There was evidence of divergent validity, as the overall DISCUS score was not associated with the variable "sex". Precision showed a high correlation coefficient between the various items and the overall DISCUS score, with only one exception (discrimination when looking for housing), which showed a particularly high frequency of "not applicable" responses. Acceptability [measured with Maximum Endorsement Frequencies (MEF) and Aggregate adjacent Endorsement Frequencies (AEF)] was found to be fair (MEF violated in 2 items; AEF partially violated in 5 item). Conclusions: The Italian version of the DISCUS is a reliable, valid, precise, and acceptable measure of experienced discrimination to be used in large scale studies in the evaluation of anti-stigma initiatives in Italy.

Published
2023

16. Satisfaction with psychiatric in-patient care as rated by patients at discharge from hospitals in 11 countries

Author

Krupchanka, Dzmitry, Khalifeh, Hind, Abdulmalik, Jibril, Ardila-Gómez, Sara, Armiya’u, Aishatu Yusha’u, Banjac, Visnja, Baranov, Alexey, Bezborodovs, Nikita, Brecic, Petrana, Čavajda, Zoran, de Girolamo, Giovanni, Denisenko, Maria, Dickens, Howard Akena, Dujmovic, Josip, Ergovic Novotny, Dubravka, Fedotov, Ilya, Fernández, Marina A., Frankova, Iryna, Gasparovic, Marta, Giurgi-Oncu, Catalina, Grahovac, Tanja, James, Bawo O., Jomli, Rabaa, Kekin, Ivana, Knez, Rajna, Lanfredi, Mariangela, Lassman, Francesca, Mehta, Nisha, Nacef, Fethi, Nawka, Alexander, Nemirovsky, Martin, Ola, Bolanle Adeyemi, Oshodi, Yewande O., Ouali, Uta, Peharda, Tomislav, Razic Pavicic, Andrea, Rojnic Kuzman, Martina, Roventa, Costin, Shamenov, Rinat, Smirnova, Daria, Smoljanic, Davorka, Spikina, Anna, Thornicroft, Amalia, Tomicevic, Marko, Vidovic, Domagoj, Williams, Paul, Yakovleva, Yulia, Zhabenko, Olena, Zhilyaeva, Tatiana, Zivkovic, Maja, Thornicroft, Graham, and Sartorius, Norman

Published
2017
Full Text
View/download PDF

17. The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: Evidence of validity

Author

Albert, Marilyn S., Bennet, David, Camicioli, Richard, Collins, D. Louis, Dubois, Bruno, Hampel, Harald, denHeijer, Tom, Hock, Christofer, Jagust, William, Launer, Leonore, Maller, Jerome J., Mueller, Susan, Sachdev, Perminder, Simmons, Andy, Thompson, Paul M., Visser, Peter-Jelle, Wahlund, Lars-Olof, Weiner, Michael W., Winblad, Bengt, Frisoni, Giovanni B., Jack, Clifford R., Jr., Bocchetta, Martina, Bauer, Corinna, Frederiksen, Kristian S., Liu, Yawu, Preboske, Gregory, Swihart, Tim, Blair, Melanie, Cavedo, Enrica, Grothe, Michel J., Lanfredi, Mariangela, Martinez, Oliver, Nishikawa, Masami, Portegies, Marileen, Stoub, Travis, Ward, Chadwich, Apostolova, Liana G., Ganzola, Rossana, Wolf, Dominik, Barkhof, Frederik, Bartzokis, George, DeCarli, Charles, Csernansky, John G., deToledo-Morrell, Leyla, Geerlings, Mirjam I., Kaye, Jeffrey, Killiany, Ronald J., Lehéricy, Stephane, Matsuda, Hiroshi, O'Brien, John, Silbert, Lisa C., Scheltens, Philip, Soininen, Hilkka, Teipel, Stefan, Waldemar, Gunhild, Fellgiebel, Andreas, Barnes, Josephine, Firbank, Michael, Gerritsen, Lotte, Henneman, Wouter, Malykhin, Nikolai, Pruessner, Jens C., Wang, Lei, Watson, Craig, Wolf, Henrike, deLeon, Mony, Pantel, Johannes, Ferrari, Clarissa, Bosco, Paolo, Pasqualetti, Patrizio, Duchesne, Simon, Duvernoy, Henri, and Boccardi, Marina

Published
2015
Full Text
View/download PDF

18. Validazione italiana della scala DISCUS (DISC-Ultra Short), uno strumento standardizzato breve per valutare la discriminazione sperimentata nelle persone con disturbi mentali. [Validation of the Italian version of the DISCUS (DISC-Ultra Short), a brief standardized scale for assessing experienced discrimination among people with mental disorders.]

Author

Lasalvia, Antonio, Ingrosso, Nicoletta, Fiorillo, Andrea, Sampogna, Gaia, Lanfredi, Mariangela, Rossi, Roberta, Evans-Lacko, Sara, Bakolis, Ioannis, Rüsch, Nicolas, and Bonetto, Chiara

Subjects
psychometrics, proprietà psicometriche, stigma, Assessment, discrimination, mental health, psychometrics, stigma, Assessment, discriminazione, proprietà psicometriche, salute mentale, stigma, Assessment, discriminazione, mental health, discrimination, salute mentale
Published
2023

22. Global pattern of experienced and anticipated discrimination reported by people with major depressive disorder: a cross-sectional survey

Author

Lasalvia, Antonio, Zoppei, Silvia, Van Bortel, Tine, Bonetto, Chiara, Cristofalo, Doriana, Wahlbeck, Kristian, Bacle, Simon Vasseur, Van Audenhove, Chantal, van Weeghel, Jaap, Reneses, Blanca, Germanavicius, Arunas, Economou, Marina, Lanfredi, Mariangela, Ando, Shuntaro, Sartorius, Norman, Lopez-Ibor, Juan J, and Thornicroft, Graham

Published
2013
Full Text
View/download PDF

23. Measuring discrimination experienced by people with a mental illness: replication of the short-form DISCUS in six world regions.

Author

Brohan, Elaine, Thornicroft, Graham, Rüsch, Nicolas, Lasalvia, Antonio, Campbell, Megan M., Yalçınkaya-Alkar, Özden, Lanfredi, Mariangela, Ochoa, Susana, Üçok, Alp, Tomás, Catarina, Fadipe, Babatunde, Sebes, Julia, Fiorillo, Andrea, Sampogna, Gaia, Paula, Cristiane Silvestre, Valverde, Leonidas, Schomerus, Georg, Klemm, Pia, Ouali, Uta, and Castelein, Stynke

Subjects
PSYCHIATRIC diagnosis, MENTAL depression risk factors, SUICIDE risk factors, FRIENDSHIP, WELL-being, RESEARCH evaluation, DISCRIMINATION (Sociology), RESEARCH methodology evaluation, RESEARCH methodology, WORK, BECK Hopelessness Scale, HEALTH outcome assessment, SOCIAL stigma, PSYCHOMETRICS, AVOIDANCE (Psychology), CRONBACH'S alpha, SUICIDAL ideation, FACTOR analysis, QUESTIONNAIRES, RESEARCH funding, MENTAL illness, CONSCIOUSNESS
Abstract

Background: The Discrimination and Stigma Scale (DISC) is a patient-reported outcome measure which assesses experiences of discrimination among persons with a mental illness globally. Methods: This study evaluated whether the psychometric properties of a short-form version, DISC-Ultra Short (DISCUS) (11-item), could be replicated in a sample of people with a wide range of mental disorders from 21 sites in 15 countries/territories, across six global regions. The frequency of experienced discrimination was reported. Scaling assumptions (confirmatory factor analysis, inter-item and item-total correlations), reliability (internal consistency) and validity (convergent validity, known groups method) were investigated in each region, and by diagnosis group. Results: 1195 people participated. The most frequently reported experiences of discrimination were being shunned or avoided at work (48.7%) and discrimination in making or keeping friends (47.2%). Confirmatory factor analysis supported a unidimensional model across all six regions and five diagnosis groups. Convergent validity was confirmed in the total sample and within all regions [ Internalised Stigma of Mental Illness (ISMI-10): 0.28–0.67, stopping self: 0.54–0.72, stigma consciousness: −0.32–0.57], as was internal consistency reliability (α = 0.74–0.84). Known groups validity was established in the global sample with levels of experienced discrimination significantly higher for those experiencing higher depression [Patient Health Questionnaire (PHQ)-2: p < 0.001], lower mental wellbeing [Warwick-Edinburgh Well-being Scale (WEMWBS): p < 0.001], higher suicidal ideation [Beck Hopelessness Scale (BHS)-4: p < 0.001] and higher risk of suicidal behaviour [Suicidal Ideation Attributes Scale (SIDAS): p < 0.001]. Conclusions: The DISCUS is a reliable and valid unidimensional measure of experienced discrimination for use in global settings with similar properties to the longer DISC. It offers a brief assessment of experienced discrimination for use in clinical and research settings. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

26. Measuring discrimination experienced by people with a mental illness: replication of the short-form DISCUS in six world regions

Author

Brohan, Elaine, primary, Thornicroft, Graham, additional, Rüsch, Nicolas, additional, Lasalvia, Antonio, additional, Campbell, Megan M., additional, Yalçınkaya-Alkar, Özden, additional, Lanfredi, Mariangela, additional, Ochoa, Susana, additional, Üçok, Alp, additional, Tomás, Catarina, additional, Fadipe, Babatunde, additional, Sebes, Julia, additional, Fiorillo, Andrea, additional, Sampogna, Gaia, additional, Paula, Cristiane Silvestre, additional, Valverde, Leonidas, additional, Schomerus, Georg, additional, Klemm, Pia, additional, Ouali, Uta, additional, Castelein, Stynke, additional, Alexová, Aneta, additional, Oexle, Nathalie, additional, Guimarães, Patrícia Neves, additional, Sportel, Bouwina Esther, additional, Chang, Chih-Cheng, additional, Li, Jie, additional, Shanthi, Chilasagaram, additional, Reneses, Blanca, additional, Bakolis, Ioannis, additional, and Evans-Lacko, Sara, additional

Published
2022
Full Text
View/download PDF

27. Additional file 1 of Adolescents’ mental health and maladaptive behaviors before the Covid-19 pandemic and 1-year after: analysis of trajectories over time and associated factors

Author

Pedrini, Laura, Meloni, Serena, Lanfredi, Mariangela, Ferrari, Clarissa, Geviti, Andrea, Cattaneo, Annamaria, and Rossi, Roberta

Abstract

Additional file 1: Table S1. Descriptive statistics of the mental health index changes in the three groups found by K-means cluter analysis. Table S2. Mean score before pandemic by categories of change (Worsened, Stable, Improved) found by K-means cluster analysis. Figure S1. Dendrogram of the Hierarchical Cluster analysis (Ward’s method) on the four mental health indexes before pandemia (T0).

Published
2022
Full Text
View/download PDF

29. The Italian Version of the Brief Assessment of Cognition in Affective Disorders: Performance of Patients with Bipolar Disorder and Healthy Controls

Author

Rossetti, Maria Gloria, primary, Perlini, Cinzia, additional, Abbiati, Vera, additional, Bonivento, Carolina, additional, Caletti, Elisabetta, additional, Fanelli, Giuseppe, additional, Lanfredi, Mariangela, additional, Lazzaretti, Matteo, additional, Pedrini, Laura, additional, Piccin, Sara, additional, Porcelli, Stefano, additional, Sala, Michela, additional, Serretti, Alessandro, additional, Bellani, Marcella, additional, and Brambilla, Paolo, additional

Published
2022
Full Text
View/download PDF

31. Perspectives of healthcare providers, service users, and family members about mental illness stigma in primary care settings: A multi-site qualitative study of seven countries in Africa, Asia, and Europe

Author

Koschorke, Mirja, primary, Oexle, Nathalie, additional, Ouali, Uta, additional, Cherian, Anish V., additional, Deepika, Vayankarappadam, additional, Mendon, Gurucharan Bhaskar, additional, Gurung, Dristy, additional, Kondratova, Lucie, additional, Muller, Matyas, additional, Lanfredi, Mariangela, additional, Lasalvia, Antonio, additional, Bodrogi, Andrea, additional, Nyulászi, Anna, additional, Tomasini, Mario, additional, El Chammay, Rabih, additional, Abi Hana, Racha, additional, Zgueb, Yosra, additional, Nacef, Fethi, additional, Heim, Eva, additional, Aeschlimann, Anaïs, additional, Souraya, Sally, additional, Milenova, Maria, additional, van Ginneken, Nadja, additional, Thornicroft, Graham, additional, and Kohrt, Brandon A., additional

Published
2021
Full Text
View/download PDF

34. Perspectives of healthcare providers, service users, and family members about mental illness stigma in primary care settings: A multi-site qualitative study of seven countries in Africa, Asia, and Europe

Author

Koschorke, Mirja, Oexle, Nathalie, Ouali, Uta, Cherian, Anish V, Deepika, Vayankarappadam, Mendon, Gurucharan Bhaskar, Gurung, Dristy, Kondratova, Lucie; https://orcid.org/0000-0003-0239-6208, Muller, Matyas; https://orcid.org/0000-0003-2343-9684, Lanfredi, Mariangela, Lasalvia, Antonio, Bodrogi, Andrea, Nyulászi, Anna; https://orcid.org/0000-0003-1087-0379, Tomasini, Mario, El Chammay, Rabih, Abi Hana, Racha; https://orcid.org/0000-0001-9973-5418, Zgueb, Yosra, Nacef, Fethi, Heim, Eva; https://orcid.org/0000-0001-7434-7451, Aeschlimann, Anaïs, Souraya, Sally, Milenova, Maria; https://orcid.org/0000-0002-6798-8178, van Ginneken, Nadja, Thornicroft, Graham, Kohrt, Brandon A; https://orcid.org/0000-0002-3829-4820, Koschorke, Mirja, Oexle, Nathalie, Ouali, Uta, Cherian, Anish V, Deepika, Vayankarappadam, Mendon, Gurucharan Bhaskar, Gurung, Dristy, Kondratova, Lucie; https://orcid.org/0000-0003-0239-6208, Muller, Matyas; https://orcid.org/0000-0003-2343-9684, Lanfredi, Mariangela, Lasalvia, Antonio, Bodrogi, Andrea, Nyulászi, Anna; https://orcid.org/0000-0003-1087-0379, Tomasini, Mario, El Chammay, Rabih, Abi Hana, Racha; https://orcid.org/0000-0001-9973-5418, Zgueb, Yosra, Nacef, Fethi, Heim, Eva; https://orcid.org/0000-0001-7434-7451, Aeschlimann, Anaïs, Souraya, Sally, Milenova, Maria; https://orcid.org/0000-0002-6798-8178, van Ginneken, Nadja, Thornicroft, Graham, and Kohrt, Brandon A; https://orcid.org/0000-0002-3829-4820

Abstract

Background: Stigma among healthcare providers is a barrier to the effective delivery of mental health services in primary care. Few studies have been conducted in primary care settings comparing the attitudes of healthcare providers and experiences of people with mental illness who are service users in those facilities. Such research is necessary across diverse global settings to characterize stigma and inform effective stigma reduction. Methods: Qualitative research was conducted on mental illness stigma in primary care settings in one low-income country (Nepal), two lower-middle income countries (India, Tunisia), one upper-middle-income country (Lebanon), and three high-income countries (Czech Republic, Hungary, Italy). Qualitative interviews were conducted with 248 participants: 64 primary care providers, 11 primary care facility managers, 111 people with mental illness, and 60 family members of people with mental illness. Data were analyzed using framework analysis. Results: Primary care providers endorsed some willingness to help persons with mental illness but reported not having appropriate training and supervision to deliver mental healthcare. They expressed that people with mental illness are aggressive and unpredictable. Some reported that mental illness is incurable, and mental healthcare is burdensome and leads to burnout. They preferred mental healthcare to be delivered by specialists. Service users did not report high levels of discrimination from primary care providers; however, they had limited expectations of support from primary care providers. Service users reported internalized stigma and discrimination from family and community members. Providers and service users reported unreliable psychiatric medication supply and lack of facilities for confidential consultations. Limitations of the study include conducting qualitative interviews in clinical settings and reliance on clinician-researchers in some sites to conduct interviews, which potentially

Published
2021

36. Aberrant Structural Connectivity of the Triple Network System in Borderline Personality Disorder Is Associated with Behavioral Dysregulation.

Author

Quattrini, Giulia, Magni, Laura Rosa, Lanfredi, Mariangela, Pedrini, Laura, Carcione, Antonino, Riccardi, Ilaria, Corbo, Daniele, Gasparotti, Roberto, Rossi, Roberta, and Pievani, Michela

Subjects
BORDERLINE personality disorder, DEFAULT mode network, EXECUTIVE function, SALIENCE network, LARGE-scale brain networks
Abstract

Background: Core symptoms of Borderline Personality Disorder (BPD) are associated to aberrant connectivity of the triple network system (salience network [SN], default mode network [DMN], executive control network [ECN]). While functional abnormalities are widely reported, structural connectivity (SC) and anatomical changes have not yet been investigated. Here, we explored the triple network's SC, structure, and its association with BPD clinical features. Methods: A total of 60 BPD and 26 healthy controls (HC) underwent a multidomain neuropsychological and multimodal MRI (diffusion- and T1-weighted imaging) assessment. Metrics (fractional anisotropy [FA], mean diffusivity [MD], cortical thickness) were extracted from SN, DMN, ECN (triple network), and visual network (control network) using established atlases. Multivariate general linear models were conducted to assess group differences in metrics and associations with clinical features. Results: Patients showed increased MD in the anterior SN, dorsal DMN, and right ECN compared to HC. Diffusivity increases were more pronounced in patients with higher behavioral dysregulation, i.e., suicidal attempting, self-harm, and aggressiveness. No differences were detected in network structure. Conclusions: These results indicate that the triple network system is impaired in BPD at the microstructural level. The preferential involvement of anterior and right-lateralized subsystems and their clinical association suggests that these abnormalities could contribute to behavioral dysregulation. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

37. Neurobiological and clinical effect of metacognitive interpersonal therapy vs structured clinical model: study protocol for a randomized controlled trial

Author

Magni, LAURA ROSA, Carcione, Antonino, Ferrari, Clarissa, Semerari, Antonio, Riccardi, Ilaria, Nicolo', Giuseppe, Lanfredi, Mariangela, Pedrini, Laura, Cotelli, Maria, Bocchio, Luisella, Pievani, Michela, Gasparotti, Roberto, Rossi, Roberta, Rossi, R, Magni, Lr, Lanfredi, M, Pedrini, L, Carcione, A, Semerari, A, Riccardi, I, Nicolo', G, Almici, M, Beneduce, R, Borsci, G, Caprioli, C, Nodari, M, Vita, A, Barlati, S, Laffranchini, L, Rillosi, L, Rossi, G, Bocchio, L, Cattaneo, A, Cattane, N, Tura, Gb, Bignotti, S, Speziali, M, Cotelli, M, Rosini, S, Gasparotti, R, Ambrosi, C, Mascaro, L, Corbo, D, Pievani, M, Quattrini, G, Bilotta, E, Colle, L, Conti, L, Fiore, D, Micheloni, A, Procacci, M, and Silvestre, V.

Subjects
Adult, Male, Adolescent, lcsh:RC435-571, Settore M-PSI/02 - PSICOBIOLOGIA E PSICOLOGIA FISIOLOGICA, medicine.medical_treatment, Neuroimaging, Impulsivity, law.invention, Study Protocol, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Alexithymia, law, Emotionality, lcsh:Psychiatry, mental disorders, medicine, Humans, 030212 general & internal medicine, Borderline personality disorder, Interpersonal Psychotherapy, Emotion dysregulation, Metacognition, Psychotherapy, business.industry, Borderline Personality Disorder, Female, Middle Aged, Treatment Outcome, medicine.disease, 030227 psychiatry, Clinical trial, Cognitive behavioral therapy, Psychiatry and Mental health, Adjunctive treatment, medicine.symptom, business, Clinical psychology
Abstract

Background Borderline Personality Disorder (BPD) is a complex and debilitating disorder, characterized by deficits in metacognition and emotion dysregulation. The “gold standard” treatment for this disorder is psychotherapy with pharmacotherapy as an adjunctive treatment to target state symptoms. The present randomized clinical trial aims to assess the clinical and neurobiological changes following Metacognitive Interpersonal Therapy (MIT) compared with Structured Clinical Management (SCM) derived from specific recommendations in APA (American Psychiatric Association) guidelines for BPD. Methods The study design is a randomized parallel controlled clinical trial and will include 80 BPD outpatients, aged 18–45 enrolled at 2 recruitment centers. Primary outcome will be the clinical change in emotion regulation capacities assessed with the Difficulties in Emotion Regulation Scale (DERS). We will also investigated the effect of psychotherapy on metacognitive abilities and several clinical features such as BPD symptomatology, general psychopathology, depression, personal functioning, and trait dimensions (anger, impulsivity, alexithymia). We will evaluate changes in brain connectivity patterns and during the view of emotional pictures. A multidimensional assessment will be performed at the baseline, at 6, 12, 18 months. We will obtain structural and functional Magnetic Resonance Images (MRIs) in MIT-Treated BPD (N = 30) and SCM-treated BPD (N = 30) at baseline and after treatment, as well as in a group of 30 healthy and unrelated volunteers that will be scanned once for comparison. Discussion The present study could contribute to elucidate the neurobiological mechanisms underlying psychotherapy efficacy. The inclusion of a multidisciplinary study protocol will allow to study BPD considering different features that can affect the treatment response and their reciprocal relationships. Trial registration NCT02370316. Registered 02/24/2015. Electronic supplementary material The online version of this article (10.1186/s12888-019-2127-2) contains supplementary material, which is available to authorized users.

Published
2019
Full Text
View/download PDF

38. Additional file 1: of Neurobiological and clinical effect of metacognitive interpersonal therapy vs structured clinical model: study protocol for a randomized controlled trial

Author

Magni, Laura, Carcione, Antonino, Ferrari, Clarissa, Semerari, Antonio, Riccardi, Ilaria, Nicolo’, Giuseppe, Lanfredi, Mariangela, Pedrini, Laura, Cotelli, Maria, Bocchio, Luisella, Pievani, Michela, Gasparotti, Roberto, and Rossi, Roberta

Abstract

SPIRIT 2013 Checklist. (DOC 128 kb)

Published
2019
Full Text
View/download PDF

41. ATTITUDES OF MENTAL HEALTH STAFF TOWARD PATIENTS WITH BORDERLINE PERSONALITY DISORDER: AN ITALIAN CROSS-SECTIONAL MULTISITE STUDY.

Author

Lanfredi, Mariangela, Ridolfi, Maria Elena, Occhialini, Giorgia, Pedrini, Laura, Ferrari, Clarissa, Lasalvia, Antonio, Gunderson, John G., Black, Donald W., and Rossi, Roberta

Subjects
*RESEARCH, *ATTITUDES of medical personnel, *BORDERLINE personality disorder, *CROSS-sectional method, *SOCIAL workers, *WORK, *MENTAL health, *HUMANITY, *HOSPITAL nursing staff, *EXPERIENTIAL learning
Abstract

Negative attitudes toward borderline personality disorder (BPD) can present a barrier to those seeking care. We explored caring attitudes toward BPD among 860 mental health professionals, including psychiatrists, psychologists, social health educators, nurses, and social workers. The results showed that social workers and nurses scored significantly lower on caring attitudes than psychiatrists, social health educators, and psychologists. Our analysis showed that the more BPD patients treated in the past year, more years of experience in mental health, and having prior BPD training were positively associated with caring attitudes scores. For all professional subgroups, except for social health educators, the caring attitudes score is higher in those who have had prior BPD training, and for professionals with low and medium level of experience in mental health. This result shows that training on BPD should target less experienced clinicians and those professional groups who had less opportunity to receive such education. [ABSTRACT FROM AUTHOR]

Published
2021

43. Health of the Nation Outcome Scales--Residential Facility

Author

Pedrini, Laura, primary, Lanfredi, Mariangela, additional, Ferrari, Clarissa, additional, Andreose, Sonia, additional, Basso, Pasquale, additional, Beneduce, Rossella, additional, Pioli, Rosaria, additional, Rillosi, Luciana, additional, Rossi, Giuseppe, additional, Rossi, Roberta, additional, and Tura, Giovanni Battista, additional

Published
2018
Full Text
View/download PDF

44. Discrimination in the workplace, reported by people with major depressive disorder: a cross-sectional study in 35 countries

Author

Brouwers, E. P M, Mathijssen, J., Van Bortel, T., Knifton, L., Wahlbeck, K., Van Audenhove, C., Kadri, N., Chang, Ch, Goud, B. R., Ballester, D., Tófoli, L. F., Bello, R., Jorge-Monteiro, M. F., Zäske, H., Milacic, I., Uçok, A., Bonetto, C., Lasalvia, A., Thornicroft, G., Van Weeghel, J., Thornicroft, Graham, Van Bortel, Tine, Treacy, Samantha, Brohan, Elaine, Ando, Shuntaro, Rose, Diana, Wahlbeck, Kristian, Aromaa, Esa, Nordmyr, Johanna, Nyqvist, Fredrica, Herberts, Carolina, Lewis, Oliver, Russo, Jasna, Karsay, Dorottya, Maglajlic, Rea, Lasalvia, Antonio, Zoppei, Silvia, Cristofalo, Doriana, Bonetto, Chiara, Goldie, Isabella, Knifton, Lee, Quinn, Neil, Sartorius, Norman, Van Audenhove, Chantal, Scheerder, Gert, Tambuyzer, Else, Hristakeva, Valentina, Germanov, Dimitar, Roelandt, Jean Luc, Bacle, Simon Vasseur, Daumerie, Nicolas, Caria, Aude, Zaske, Harald, Gaebel, Wolfgang, Economou, Marina, Louki, Eleni, Peppou, Lily, Geroulanou, Klio, Harangozo, Judit, Sebes, Julia, Csukly, Gabor, Rossi, Giuseppe, Lanfredi, Mariangela, Pedrini, Laura, Germanavicius, Arunas, Markovskaja, Natalja, Valantinas, Vytis, Van Weeghel, Jaap, Boumans, Jenny, Willemsen, Eleonoor, Plooy, Annette, Duarte, Teresa, Monteiro, Fatima Jorge, Teodorescu, Radu, Radu, Iuliana, Pana, Elena, Hurova, Janka, Leczova, Dita, Svab, Vesna, Konecnik, Nina, Reneses, Blanca, Lopez-Ibor, Juan J., Palomares, Nerea, Bayon, Camila, Uçok, Alp, Karaday, Gulsah, Glozier, Nicholas, Cockayne, Nicole, Tófoli, Luís Fernando, Costa, Maria Suely Alves, Milev, Roumen, Garrah, Teresa, Tackaberry, Liane, Stuart, Heather, Margetic, Branka Aukst, Groiæ, Petra Folnegovic, Wenigova, Barbora, Pavla, Elepova, Radwan, Doaa Nader, Johnson, Pradeep, Goud, Ramakrishna, Nandesh, N., Jayaram, Geetha, Suzuki, Yuriko, Akiyama, Tsuyoshi, Matsunaga, Asami, Bernick, Peter, James, Bawo, Ola, Bolanle, Owoeye, Olugbenga, Oshodi, Yewande, Abdulmalik, Jibril, Chee, Kok Yoon, Ali, Norhayati, Kadri, Nadia, Belghazi, Dounia, Anwar, Yassine, Khan, Nashi, Kausar, Rukhsana, Vidojevic, Ivona Milacic, Sumathipala, Athula, Chang, Chih Cheng, Nacef, Fethi, Ouali, Uta, Ouertani, Hayet, Jomli, Rabaa, Ouertani, Abdelhafidh, Kaaniche, Khadija, Bello, Ricardo, Ortega, Manuel, Melone, Arturo, Andréina, María, Marco, Francisco, Ríos, Arturo, Rodríguez, Ernesto, Laguado, Arianna, Van Bortel, Tine [0000-0003-0467-6393], Apollo - University of Cambridge Repository, Tranzo, Scientific center for care and wellbeing, and Arbeid & Gezondheid

Subjects
Male, OCCUPATIONAL & INDUSTRIAL MEDICINE, discrimination, human development index, stigma, work, Social stigma, Cross-sectional study, Social Stigma, HN, 0302 clinical medicine, 030212 general & internal medicine, Workplace, media_common, General Medicine, Middle Aged, Mental Health, Major depressive disorder, Female, Developed country, Prejudice, Adult, Employment, medicine.medical_specialty, media_common.quotation_subject, Stigma (botany), OCCUPATIONAL &amp, Affect (psychology), behavioral disciplines and activities, 03 medical and health sciences, mental disorders, medicine, Humans, Psychiatry, Depressive Disorder, Major, Depressive Disorder, business.industry, Research, Major, medicine.disease, Mental health, 030227 psychiatry, Cross-Sectional Studies, Logistic Models, Multivariate Analysis, Unemployment, INDUSTRIAL MEDICINE, business
Abstract

Objective: Whereas employment has been shown to be beneficial for people with Major Depressive Disorder (MDD) across different cultures, employers’ attitudes have been shown to be negative towards workers with MDD. This may form an important barrier to work participation. Today, little is known about how stigma and discrimination affect work participation of workers with MDD, especially from their own perspective. We aimed to assess, in a working age population including respondents with MDD from 35 countries: (1) if people with MDD anticipate and experience discrimination when trying to find or keep paid employment; (2) if participants in high, middle and lower developed countries differ in these respects; and (3) if discrimination experiences are related to actual employment status (ie, having a paid job or not).Method: Participants in this cross-sectional study (N=834) had a diagnosis of MDD in the previous 12 months. They were interviewed using the Discrimination and Stigma Scale (DISC-12). Analysis of variance and generalised linear mixed models were used to analyse the data.Results: Overall, 62.5% had anticipated and/or experienced discrimination in the work setting. In very high developed countries, almost 60% of respondents had stopped themselves from applying for work, education or training because of anticipated discrimination. Having experienced workplace discrimination was independently related to unemployment.Conclusions: Across different countries and cultures, people with MDD very frequently reported discrimination in the work setting. Effective interventions are needed to enhance work participation in people with MDD, focusing simultaneously on decreasing stigma in the work environment and on decreasing self-discrimination by empowering workers with MDD.

Published
2016
Full Text
View/download PDF

47. Relations of mindfulness facets with psychological symptoms among individuals with a diagnosis of obsessive–compulsive disorder, major depressive disorder, or borderline personality disorder.

Author

Didonna, Fabrizio, Rossi, Roberta, Ferrari, Clarissa, Iani, Luca, Pedrini, Laura, Rossi, Nicoletta, Xodo, Erica, and Lanfredi, Mariangela

Subjects
DIAGNOSIS of mental depression, DIAGNOSIS of obsessive-compulsive disorder, BORDERLINE personality disorder, ANALYSIS of covariance, ANALYSIS of variance, MATHEMATICAL models, PSYCHOLOGICAL tests, PSYCHOLOGY, QUESTIONNAIRES, MINDFULNESS, DIAGNOSIS
Abstract

Objectives: To explore differences in mindfulness facets among patients with a diagnosis of either obsessive–compulsive disorder (OCD), major depressive disorder (MDD), or borderline personality disorder (BPD), and healthy controls (HC), and their associations with clinical features. Design and method: One hundred and fifty‐three patients and 50 HC underwent a clinical assessment including measures of mindfulness (Five Facets Mindfulness Questionnaire – FFMQ), psychopathological symptoms (Symptom Check List‐90‐R), dissociation (Dissociative Experience Scale), alexithymia (Alexithymia Scale 20), and depression (Beck Depression Inventory‐II). Analysis of variance (ANOVA) and analysis of covariance (ANCOVA) were performed to assess differences in mindfulness scores and their associations with clinical features. Results: The three diagnostic groups scored lower on all mindfulness facets (apart from FFMQobserving) compared to the HC group. OCD group had a significant higher FFMQ total score (FFMQ‐TS) and FFMQacting with awareness compared to the BPD group, and scored higher on FFMQdescribing compared to BPD and MDD groups. The scores in non‐judging facet were significantly lower in all the three diagnostic groups compared to the HC group. Interestingly, higher FFMQ‐TS was inversely related to all psychological measures, regardless of diagnostic group. Conclusions: Deficits in mindfulness skills were present in all diagnostic groups. Furthermore, we found disease‐specific relationships between some mindfulness facets and specific psychological variables. Clinical implications are discussed. Practitioner points: The study showed deficits in mindfulness scores in all diagnostic groups compared to a healthy control group.Overall, mindfulness construct has a significantly negative association with indexes of global distress, dissociative symptoms, alexithymia, and depression.Mindfulness‐based interventions in clinical settings should take into account different patterns of mindfulness skills and their impact on disease‐specific maladaptive cognitive strategies or symptomatology. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

49. The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance:Evidence of validity

Author

Frisoni, Giovanni B, Jack, Clifford R, Bocchetta, Martina, Bauer, Corinna, Frederiksen, Kristian S, Liu, Yawu, Preboske, Gregory, Swihart, Tim, Blair, Melanie, Cavedo, Enrica, Grothe, Michel J, Lanfredi, Mariangela, Martinez, Oliver, Nishikawa, Masami, Portegies, Marileen, Stoub, Travis, Ward, Chadwich, Apostolova, Liana G, Ganzola, Rossana, Wolf, Dominik, Barkhof, Frederik, Bartzokis, George, DeCarli, Charles, Csernansky, John G, deToledo-Morrell, Leyla, Geerlings, Mirjam I, Kaye, Jeffrey, Killiany, Ronald J, Lehéricy, Stephane, Matsuda, Hiroshi, O'Brien, John, Silbert, Lisa C, Scheltens, Philip, Soininen, Hilkka, Teipel, Stefan, Waldemar, Gunhild, Fellgiebel, Andreas, Barnes, Josephine, Firbank, Michael, Gerritsen, Lotte, Henneman, Wouter, Malykhin, Nikolai, Pruessner, Jens C, Wang, Lei, Watson, Craig, Wolf, Henrike, deLeon, Mony, Pantel, Johannes, Ferrari, Clarissa, Bosco, Paolo, Frisoni, Giovanni B, Jack, Clifford R, Bocchetta, Martina, Bauer, Corinna, Frederiksen, Kristian S, Liu, Yawu, Preboske, Gregory, Swihart, Tim, Blair, Melanie, Cavedo, Enrica, Grothe, Michel J, Lanfredi, Mariangela, Martinez, Oliver, Nishikawa, Masami, Portegies, Marileen, Stoub, Travis, Ward, Chadwich, Apostolova, Liana G, Ganzola, Rossana, Wolf, Dominik, Barkhof, Frederik, Bartzokis, George, DeCarli, Charles, Csernansky, John G, deToledo-Morrell, Leyla, Geerlings, Mirjam I, Kaye, Jeffrey, Killiany, Ronald J, Lehéricy, Stephane, Matsuda, Hiroshi, O'Brien, John, Silbert, Lisa C, Scheltens, Philip, Soininen, Hilkka, Teipel, Stefan, Waldemar, Gunhild, Fellgiebel, Andreas, Barnes, Josephine, Firbank, Michael, Gerritsen, Lotte, Henneman, Wouter, Malykhin, Nikolai, Pruessner, Jens C, Wang, Lei, Watson, Craig, Wolf, Henrike, deLeon, Mony, Pantel, Johannes, Ferrari, Clarissa, and Bosco, Paolo

Abstract

BACKGROUND: An international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of the hippocampus on MR. The aim of this study is to study the concurrent validity of the HarP toward local protocols, and its major sources of variance.METHODS: Fourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative (ADNI) cases scanned at 1.5 T and 3T following local protocols, qualified for segmentation based on the HarP through a standard web-platform and resegmented following the HarP. The five most accurate tracers followed the HarP to segment 15 ADNI cases acquired at three time points on both 1.5 T and 3T.RESULTS: The agreement among tracers was relatively low with the local protocols (absolute left/right ICC 0.44/0.43) and much higher with the HarP (absolute left/right ICC 0.88/0.89). On the larger set of 15 cases, the HarP agreement within (left/right ICC range: 0.94/0.95 to 0.99/0.99) and among tracers (left/right ICC range: 0.89/0.90) was very high. The volume variance due to different tracers was 0.9% of the total, comparing favorably to variance due to scanner manufacturer (1.2), atrophy rates (3.5), hemispheric asymmetry (3.7), field strength (4.4), and significantly smaller than the variance due to atrophy (33.5%, P < .001), and physiological variability (49.2%, P < .001).CONCLUSIONS: The HarP has high measurement stability compared with local segmentation protocols, and good reproducibility within and among human tracers. Hippocampi segmented with the HarP can be used as a reference for the qualification of human tracers and automated segmentation algorithms.

Published
2015

50. IC-P-124: VALIDATION OF THE EADC-ADNI HARMONIZED PROTOCOL FOR MANUAL HIPPOCAMPAL SEGMENTATION

Author

Boccardi, Marina, primary, Jack, Clifford, additional, Bocchetta, Martina, additional, Bauer, Corinna, additional, Frederiksen, Kristian Steen, additional, Liu, Yawu, additional, Preboske, Gregory, additional, Swihart, Tim, additional, Blair, Melanie, additional, Cavedo, Enrica, additional, Grothe, Michel, additional, Lanfredi, Mariangela, additional, Martinez, Oliver, additional, Nishikawa, Masami, additional, Portegies, Marileen, additional, Stoub, Travis, additional, Ward, Chad, additional, Apostolova, Liana, additional, Ganzola, Rossana, additional, Wolf, Dominik, additional, Ferrari, Clarissa, additional, Bosco, Paolo, additional, Duchesne, Simon, additional, and Frisoni, Giovanni B., additional

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results