144 results on '"Lanfranchi S"'
Search Results
2. Environment Learning from Virtual Exploration in Individuals with Down Syndrome: The Role of Perspective and Sketch Maps
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Toffalini, E., Meneghetti, C., Carretti, B., and Lanfranchi, S.
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Background: Spatial knowledge about an environment is an important determinant of ability to move effectively within it and of personal autonomy. Individuals with Down's syndrome (DS) have difficulty managing configural visuospatial information. Method: Twenty-nine individuals with DS and 29 typically developing (TD) children, matched for mental age, learned about environments through virtual exploration using a route or survey view. A sketch map of the environment was or was not presented before exploration. Then the acquisition of configural knowledge (landmark locations) and route retracing were tested. Results: Individuals with DS were able to acquire configural knowledge through virtual exploration in all presentation conditions, and generally performed no worse than matched TD children. However, they were not able to benefit from the conditions that facilitated acquisition of configural knowledge in TD children, that is, seeing a sketch map before exploring and exploring in survey (rather than route) view. As regards route retracing, individuals with DS paused more often than controls and tended to travel longer paths, which made them slower overall. Conclusions: DS reduces children's ability to benefit from additional survey information and may be related to difficulty in elaborating configural/simultaneous information.
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- 2018
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3. Psicologia dello sviluppo educazione
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Gini G., Lanfranchi S., Vianello R. and Gini G., Lanfranchi S., Vianello R.
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- 2019
4. Funzioni esecutive e disabilità intellettiva
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Lanfranchi, S., Fontana, M., Passolunghi, M. C., Pulina, F., Usai, M. C., G.M. Marzocchi, C. Pecini, M.C. Usai, & P. Viterbori, Lanfranchi, S., Fontana, M., Passolunghi, M. C., Pulina, F., and Usai, M. C.
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Funzioni Esecutive ,Sindrome di Down ,Memoria di Lavoro - Abstract
La disabilità intellettiva è un disturbo che si manifesta nel periodo dello sviluppo. Comporta deficit nelle funzioni intellettive, quali ragionamento, problem solving, pianificazione, pensiero astratto, capacità di giudizio, apprendimento scolastico e apprendimento dall’esperienza. Tali deficit hanno una ripercussione anche sui comportamenti messi in atto nella vita quotidiana, motivo per cui la disabilità intellettiva comporta anche un deficit nel funzionamento adattivo negli ambiti concettuale, sociale e pratico. In altre parole, nella vita di tutti i giorni i livelli di autonomia degli individui con disabilità intellettiva sono inferiori a quanto ci si aspetterebbe in base alla loro età e alla cultura di appartenenza, comportando limitazioni in una o più attività della vita quotidiana, come la comunicazione, la partecipazione sociale e la vita autonoma, attraverso molteplici ambienti quali casa, scuola, ambiente lavorativo e comunità (American Psychiatric Association, 2013).
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- 2022
5. Working Memory in Down Syndrome: Is There a Dual Task Deficit?
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Lanfranchi, S., Baddeley, A., and Gathercole, S.
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Background: Recent studies have shown that individuals with Down syndrome (DS) are poorer than controls in performing verbal and visuospatial dual tasks. The present study aims at better investigating the dual task deficit in working memory in individuals with DS. Method: Forty-five individuals with DS and 45 typically developing children matched for verbal mental age completed a series of verbal and visuospatial working memory tasks, involving conditions that either required the combination of two tasks in the same modality (verbal or visual) or of cross-modality pairs of tasks. Results and conclusions: Two distinct deficits were found in individuals with DS: impairment in verbal tasks and further impairment in all dual task conditions. The results confirm the hypothesis of a central executive impairment in individuals with DS.
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- 2012
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6. The Effect of Configuration on VSWM Performance of Down Syndrome Individuals
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Carretti, B. and Lanfranchi, S.
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Background: Recent studies have demonstrated that individuals with Down syndrome (DS) are poorer than controls in spatial-simultaneous tasks, but not in spatial-sequential tasks. To explain this finding, it has been suggested that the simultaneous visuo-spatial working memory deficit of individuals with DS could be due to the request for processing more than one item at a time. The present study examines the possibility of reducing the difficulties encountered by DS individuals on spatial-simultaneous tasks by proposing a task that uses structured material. Method: Two tasks were administered to 20 children and adolescents with DS, and 20 controls matched for verbal mental age. The tasks involved memorising and recalling filled-cell positions in a series of matrices in which an increasing number of cells (1-7) were filled. In the structured condition the filled cells were displayed to form a pattern, whereas in the random condition they were randomly arranged. Results and Conclusions: Results showed that individuals with DS are able to take advantage of structured material for raising their performance, but to a less extent than typically developing children. (Contains 2 figures, 2 tables and 2 footnotes.)
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- 2010
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7. Executive Function in Adolescents with Down Syndrome
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Lanfranchi, S., Jerman, O., and Dal Pont, E.
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Background: The present work is aimed at analysing executive function (EF) in adolescents with Down Syndrome (DS). So far, EF has been analysed mainly in adults with DS, showing a pattern of impairment. However, less is known about children and adolescents with this syndrome. Studying adolescents with DS might help us better understand whether performances on EF tasks of individuals with DS are determined by age or by Alzheimer disease, as some studies suggest, or whether their performances are directly related to DS cognitive profile. Method: A battery of EF tasks assessing set shifting, planning/problem-solving, working memory, inhibition/perseveration and fluency, as well as a tasks assessing sustained attention has been administered to a group of 15 adolescents with DS and 15 typically developing children matched for mental age. All EF tasks were selected from previous studies with individuals with intellectual disabilities or from developmental literature and are thought to be useful for the samples considered. Results: The present results revealed that the group of individuals with DS performed at a significantly lower level on tasks assessing set shifting, planning/problem-solving, working memory and inhibition/perseveration, but not on the tasks assessing fluency. In addition, individuals with DS demonstrated a greater number of errors and less strategy use for the sustained attention task. Conclusions: The results suggest a broad impairment in EF in adolescents with DS, and are consistent with several similar studies conducted with adults with DS. We assume that EF deficit is a characteristic of DS.
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- 2010
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8. A Specific Deficit in Visuospatial Simultaneous Working Memory in Down Syndrome
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Lanfranchi, S., Carretti, B., and Spano, G.
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Background: Recent studies have demonstrated that individuals with Down syndrome (DS) present both central and verbal working memory deficits compared with controls matched for mental age, whereas evidence on visuospatial working memory (VSWM) has remained ambiguous. The present paper uses a battery of VSWM tasks to test the hypothesis that individuals with DS can also encounter specific difficulties in VSWM. Method: Four tasks were administered to 34 children and adolescents with DS and 34 controls matched for verbal mental age. In two of these tasks, participants had to remember a series of locations sequentially presented on a matrix (spatial-sequential WM); in another two, they had to remember locations simultaneously presented (spatial-simultaneous WM). Results and Conclusions: Results showed that individuals with DS are poorer than controls in the spatial-simultaneous tasks, but not in the spatial-sequential tasks. These findings were not due to a difference in speed of visuospatial processing. In fact, when performances of the two groups in VSWM were compared using speed measures as covariates, differences between groups remained. It is suggested that the simultaneous VSWM deficit of individuals with DS could be due to the request for processing more than one item at a time.
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- 2009
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9. Social anxiety in children and adolescents with autism spectrum disorders
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Lievore, R, Cardillo, R, Lanfranchi, S, and Mammarella, Ic
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- 2022
10. Executive function and intellectual disability: innovations, methods and treatment
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Fidler, D. J., primary and Lanfranchi, S., additional
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- 2021
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11. Developmental trajectories of spatial‐sequential and spatial‐simultaneous working memory in Down syndrome
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Carretti, B., primary, Meneghetti, C., additional, Doerr, E., additional, Toffalini, E., additional, and Lanfranchi, S., additional
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- 2021
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12. Executive functions and adaptive behaviour in individuals with Down syndrome
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Onnivello, S., primary, Colaianni, S., additional, Pulina, F., additional, Locatelli, C., additional, Marcolin, C., additional, Ramacieri, G., additional, Antonaros, F., additional, Vione, B., additional, Piovesan, A., additional, and Lanfranchi, S., additional
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- 2021
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13. EFFECTS OF THE PLACEMENT IN TYPICAL CLASS-ROOMS OF STUDENTS WITH DOWN SYNDROME OR OTHER INTELLECTUAL DEVELOPMENTAL DISABILITIES
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Pulina, F., Vianello, R., and Lanfranchi, S.
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- 2015
14. Executive function and intellectual disability: innovations, methods and treatment.
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Fidler, D. J. and Lanfranchi, S.
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EXECUTIVE function , *ADAPTABILITY (Personality) , *SERIAL publications , *CHILD development , *PEOPLE with intellectual disabilities , *DIFFUSION of innovations - Abstract
This editorial presents an introduction to and an overview of the current JIDR special issue on "Executive Function in Intellectual Disability." The articles included in this special issue provide a contemporary, in depth exploration of questions regarding the nature of EF in individuals with ID. Topics include the emergence of EF during early childhood in ID‐related conditions, the influence of EF on other domains of development, and the relationship between EF and adaptation throughout the lifespan. This editorial synthesizes the findings presented in this special issue and identifies methodological challenges that researchers will continue to face in future investigations of this important area. [ABSTRACT FROM AUTHOR]
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- 2022
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15. Executive functions and adaptive behaviour in individuals with Down syndrome.
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Onnivello, S., Colaianni, S., Pulina, F., Locatelli, C., Marcolin, C., Ramacieri, G., Antonaros, F., Vione, B., Piovesan, A., and Lanfranchi, S.
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DIAGNOSIS of Down syndrome ,EXECUTIVE function ,ADAPTABILITY (Personality) ,MEMORY ,CAREGIVERS ,BEHAVIOR ,QUESTIONNAIRES ,COMMUNICATION ,RESEARCH funding ,PARENTS - Abstract
Background: Previous research has explored executive functions (EFs) and adaptive behaviour in children and adolescents with Down syndrome (DS), but there is a paucity of research on the relationship between the two in this population. This study aims to shed light on the profile of EFs and adaptive behaviour in DS, exploring the differences by age and investigating the relationship between these two domains. Method: Parents/caregivers of 100 individuals with DS from 3 to 16 years old participated in the study. The sample was divided into preschoolers (3–6.11 years old) and school‐age children (7–16 years old). Parents/caregivers completed either the Preschool Version of the Behaviour Rating Inventory of Executive Function (for children 2–6.11 years old) or the Second Edition of the same Inventory (for individuals 7 + years old). Adaptive behaviour was assessed with the Vineland Adaptive Behaviour Scale – Interview, Second Edition. Results: Findings suggest that individuals with DS have overall difficulties, but also patterns of strength and weakness in their EFs and adaptive behaviour. The preschool‐age and school‐age children's EF profiles differed slightly. While both age groups showed Emotional Control as a relative strength and Working Memory as a weakness, the school‐age group revealed further weaknesses in Shift and Plan/Organise. As concerns adaptive behaviour, the profiles were similar in the two age groups, with Socialisation as a strength, and Communication and Daily Living Skills as weaknesses, but with a tendency for preschoolers to obtain intermediate scores for the latter. When the relationship between EFs and adaptive behaviour was explored, Working Memory predicted Communication in the younger group, while in the older group the predictors varied, depending on the adaptive domains: Working Memory was a predictor of Communication, Inhibit of Daily Living Skills, and Inhibit and Shift of Socialisation. Conclusion: As well as elucidating the EF profiles and adaptive behaviour in individuals with DS by age, this study points to the role of EFs in adaptive functioning, providing important information for targeted interventions. [ABSTRACT FROM AUTHOR]
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- 2022
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16. Developmental trajectories of spatial‐sequential and spatial‐simultaneous working memory in Down syndrome.
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Carretti, B., Meneghetti, C., Doerr, E., Toffalini, E., and Lanfranchi, S.
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DOWN syndrome ,CROSS-sectional method ,COMPARATIVE studies ,SHORT-term memory ,SPACE perception - Abstract
Background: Working memory (WM) is generally considered an area of weakness in the cognitive profile associated with Down syndrome (DS). The great majority of studies explored WM in this population through a comparison with typical development (TD) on the basis of mental age or developmental level. However, it is also relevant to understand how these skills develop and whether such development could be more related to chronological or developmental level. In the present study, we explored cross‐sectional developmental trajectories of spatial‐sequential and spatial‐simultaneous WM in individuals with DS across chronological age and developmental level. Typically developing children (TD) of similar mental age were also included as a comparison group. Methods: Eighty‐four individuals with DS (aged between 7 and 30 years) and 327 children with TD (aged between 4 and 8 years) were administered with tasks to assess spatial‐sequential and spatial‐simultaneous WM, together with tasks to assess both general verbal and spatial developmental levels. Results and conclusion: Performance in spatial‐simultaneous WM task was lower compared with spatial‐sequential WM task in both groups. In the case of individuals with DS, the developmental trajectories of chronological age are better described through a segmented model showing increased performance until approximately 13 years of age, followed by a rather flat progress. In the case of TD children, developmental trajectories are better described through a linear model in the spatial‐simultaneous WM task when chronological age is considered; in the spatial‐sequential WM, the increase in performance with age was however characterised by a discontinuity at age 6. The increase in performance followed a linear pattern in both groups (DS and TD) without substantial differences between the types of measure used (verbal vs. spatial) when the developmental level is considered. [ABSTRACT FROM AUTHOR]
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- 2022
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17. 3D kinematic analysis and clinical evaluation of neck movements in patients with whiplash injury
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Antonaci, F, Bulgheroni, M, Ghirmai, S, Lanfranchi, S, Toffola, E Dalla, Sandrini, G, and Nappi, G
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- 2002
18. L’adattamento italiano delle Griffiths III: prima fase
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Lanfranchi, S. and Rea, M.
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- 2018
19. Vitamin 25(OH) D and cognitive function in parkinson’s disease
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Barichella, M., primary, Bolliri, C., additional, Pinelli, G., additional, Iorio, L., additional, Ferri, V., additional, Cassani, E., additional, Giana, A., additional, Caronni, S., additional, Pusani, C., additional, Del Sorbo, F., additional, Cilia, R., additional, Quacci, E., additional, Riboldazzi, G., additional, Lanfranchi, S., additional, Cereda, E., additional, and Pezzoli, G., additional
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- 2019
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20. Posterior headache as a warning symptom of vertebral dissection: a case report
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Lanfranchi, S., Di Falco, M., Perini, M., and Zarcone, D.
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- 2005
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21. Environment learning from virtual exploration in individuals with down syndrome: the role of perspective and sketch maps
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Toffalini, E., primary, Meneghetti, C., additional, Carretti, B., additional, and Lanfranchi, S., additional
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- 2017
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22. Intervention programs for individuals with Down syndrome
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Lanfranchi, S, ALESI, Marianna, Lanfranchi, S, and Alesi, M
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Settore M-PSI/04 - Psicologia Dello Sviluppo E Psicologia Dell'Educazione ,Down syndrome, intervention programs - Published
- 2014
23. Domain-specific and domain-general precursors f mathematical achievement: A longitudinal study from kindergarten to first grade
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PASSOLUNGHI, MARIA CHIARA, Lanfranchi S., Passolunghi, MARIA CHIARA, and Lanfranchi, S.
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mathematic ,mathematics ,precursors ,children ,precursor - Abstract
This research aims to verify the importance of kindergarten measures of cognitive abilities and numerical competence in the role of predicting mathematical school achievement at the end of first grade. Path analysis models revealed the direct influence of working memory and processing speed on predicting numerical competence in pre-schoolers and the influence of processing speed and verbal IQ on predicting math achievement in first graders. Moreover, this study found a direct link between numerical competence and math achievement.
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- 2012
24. Bisogni Educativi Speciali: il Funzionamento Intellettivo Limite o Borderline
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Vianello, R., DI NUOVO, Santo, and Lanfranchi, S.
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- 2014
25. Frontal assessment battery scores and non-motor symptoms in parkinsonian disorders
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Marconi, R., Grasso, L., Antonini, A., De Gaspari, D., Barone, P., Santangelo, G., Colosimo, C., Meco, G., Avarello, T. P., Bottacchi, E., Cannas, A., Ceravolo, M. G., Ceravolo, R., Cicarelli, G., Gaglio, R. M., Giglia, L., Iemolo, F., Manfredi, M., Nicoletti, A., Pederzoli, M., Petrone, A., Pisani, A., Pontieri, F. E., Quatrale, R., Ramat, S., Scala, R., Volpe, G., Zappulla, S., Bentivoglio, R., Stocchi, F., Trianni, G., Del Dotto, P., Morgante, F., Morgante, L., Fabbrini, G., Benincasa, D., Sensi, M., Braga, M., Capecci, M., Caravona, N., D'Asta, G., De Falco, F. A., Pezzoli, G., Di Giovanni, M., Floris, G., Gallerini, S., Gurgone, G., Frosini, D., Meoni, S., Savica, R., Moschella, V., Pepe, F., Petretta, V., Randisi, M. G., Romeno, M., Picillo, M., Sorbello, V., Tiple, D., Guidubaldi, A., Muoio, R., Toni, V., Logi, C., Bartalini, S., Ulivelli, M., Perini, M., Lanfranchi, S., Griffini, S., Troianiello, B., Baratti, M., Amidei, S., Consoli, D., Iellamo, M., Cuomo, T., Scaglioni, A., Medici, D., Abbruzzese, G., Di Brigida, G., Cocco, G. A., Agnetti, V., Cossu, G., Deriu, M., Abrignani, M., Modica, C., Albani, G., Pradotto, L., Martinelli, P., Scaglione, C., Mucchiut, M., Zanini, S., Pennisi, F., Soliveri, P., Albanese, A., Bartolomei, L., L'Erario, R., Capus, L., Ferigo, L., Marano, R., Nastasi, V., Luciano, R., Maiello, L., Simone, P., Fogli, D., Lopiano, L., Pesare, M., Nordera, G., Pilleri, E., Scaravilli, T., Giaccaglini, E., Alesi, C., Corbetta, T., Sgarbi, S., Rapisarda, A., Rizzoli, S., Zanoli, L., Manfredi, A., Marconi, R, Antonini, A, Barone, P, Colosimo, C, Avarello, Tp, Bottacchi, E, Cannas, A, Ceravolo, Mg, Ceravolo, R, Cicarelli, G, Gaglio, Rm, Giglia, L, Iemolo, F, Manfredi, M, Meco, G, Nicoletti, A, Pederzoli, M, Petrone, A, Pisani, A, Pontieri, Fe, Quatrale, R, Ramat, S, Scala, R, Volpe, G, Zappulla, S, Bentivoglio, Ar, Stocchi, F, Trianni, G, Del Dotto, P, De Gaspari, D, Grasso, L, Morgante, F, Santangelo, Gabriella, Fabbrini, G, Morgante, L, and PRIAMO study, Group
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Questionnaires ,Lung Diseases ,Male ,Aged ,Aged, 80 and over ,Attention Deficit Disorder with Hyperactivity ,Cardiovascular Diseases ,Cognition Disorders ,Fatigue ,Female ,Frontal Lobe ,Gastrointestinal Diseases ,Humans ,Kidney Diseases ,Logistic Models ,Longitudinal Studies ,Middle Aged ,Parkinsonian Disorders ,Predictive Value of Tests ,Skin Diseases ,Sleep Wake Disorders ,Surveys and Questionnaires ,Neuropsychological Tests ,2708 ,Neurology (clinical) ,Psychiatry and Mental Health ,Neurology ,Disease ,Logistic regression ,Parkinson and cognitive impairment ,80 and over ,Verbal fluency test ,Neuroradiology ,Sleep Disorders ,General Medicine ,non-motor symptoms ,Psychiatry and Mental health ,Settore MED/26 - NEUROLOGIA ,Frontal lobe ,Predictive value of tests ,Psychology ,medicine.medical_specialty ,Dermatology ,behavioral disciplines and activities ,Internal medicine ,medicine ,Psychiatry ,Surrogate endpoint ,Frontal functions ,Non-motor symptoms ,frontal functions ,parkinson and cognitive impairment - Abstract
Using data from the PRIAMO study, we investigated non-motor symptoms (NMS) versus frontal lobe dysfunction in patients with idiopathic Parkinson disease (PD); 808 patients with PD and 118 with atypical parkinsonisms (AP) were consecutively enrolled at 55 Centers in Italy. Twelve categories of NMS were investigated. Cognitive impairment was defined as a Mini-Mental Status Evaluation score ≤ 23.8 and frontal lobe dysfunction as a Frontal Assessment Battery (FAB) score ≤ 3.48. Multivariable logistic regression was used to identify predictor of frontal lobe dysfunction in 524 PD patients, and a generalized linear model was used for each of the six FAB items. Not only the total FAB scores but also the single FAB items were lower in AP versus PD (p ≤ 0.005). Age (OR = 1.05), cognitive impairment (OR = 9.54), lack of cardiovascular symptoms (OR = 3.25), attention or memory problems (OR = 0.59) and treatment with L: -DOPA (OR = 5.58) were predictors of frontal lobe dysfunction. MMSE was negatively associated with all FAB items (β ≤ -0.16) and age with all FAB items but prehension behavior (β ≤ -0.01). Previous use of L: -DOPA was negatively associated with verbal fluency (β = -0.32) possibly acting as surrogate marker of disease duration. Cognitive impairment is a predictor of frontal lobe dysfunction. Among NMS, lack of attention or memory problems were negatively associated with frontal impairment. Further studies are nonetheless needed to better identify the predictors of frontal impairment in PD patients.
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- 2012
26. Non-motor symptoms in atypical and secondary parkinsonism: the PRIAMO study
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Colosimo, C, Morgante, L, Antonini, A, Barone, P, Avarello, Tp, Bottacchi, E, Cannas, A, Ceravolo, Mg, Ceravolo, R, Cicarelli, G, Gaglio, Rm, Giglia, L, Iemolo, F, Manfredi, M, Meco, G, Nicoletti, A, Pederzoli, M, Petrone, A, Pisani, A, Pontieri, Fe, Quatrale, R, Ramat, S, Scala, R, Volpe, G, Zappulla, S, Bentivoglio, Ar, Stocchi, F, Trianni, G, Del Dotto, P, Simoni, L, Marconi, R, Priamo, Sg, Benincasa, D, Biguzzi, S, Braga, M, Capecci, M, Caravona, N, D'Asta, G, De Falco, Fa, De Gaspari, D, Pezzoli, G, Di Giovanni, M, Floris, G, Gallerini, S, Grasso, L, Gurgone, G, Kiferle, L, Meoni, S, Morgante, F, Savica, R, Moschella, V, Pepe, F, Petretta, V, Randisi, Mg, Romeno, M, Santangelo, G, Ianniciell, M, Sorbello, V, Fabbrini, G, Berardelli, A, Guidubaldi, A, Muoio, R, Toni, V, Logi, C, Ciacci, G, Ulivelli, M, Perini, M, Lanfranchi, S, Griffini, S, Troianiello, B, Baratti, M, Amidei, S, Consoli, D, Iellamo, M, Cuomo, T, Scaglioni, A, Medici, D, Abbruzzese, Giovanni, Di Brigida, G, Cocco, Ga, Agnetti, V, Cossu, G, Deriu, M, Abrignani, M, Modica, C, Albani, G, Milan, E, Martinelli, P, Scaglione, C, Mucchiut, M, Zanini, S, Pennisi, F, Soliveri, P, Albanese, A, Bartolomei, L, L'Erario, R, Capus, L, Ferigo, L, Marano, R, Nastasi, V, Luciano, R, Maiello, L, Simone, P, Fogli, D, Lopiano, L, Pesare, M, Nordera, G, Pilleri, E, Scaravilli, T, Giaccaglini, E, Alesi, C, Corbetta, T, Dumitriu, A, Sgarbi, S, Rapisarda, A, Rizzoli, S, Zanoli, L, Manfredi, A., Colosimo C., Morgante L., Antonini A., Barone P., Avarello T.P., Bpttacchi E., Cannas A., Ceravolo M.G., Ceravolo R., Cicarelli G., Gaglio R.M., Giglia L., Iemolo F., Manfredi M., Meco G., Nicoletti A., Pederzoli M., Petrone A., Pisani A., Pontieri FE., Quatrale r., Ramat S., Scala R., Volpe G., Zappulla S., Bentivoglio A.R., Stocchi F., Trianni G., Del Dotto P., Simoni L., Marconi R., PRIAMO STUDY GROUP [.., Martinelli P., ], Colosimo, C, Morgante, L, Antonini, A, Barone, Paolo, Avarello, Tp, Bottacchi, E, Cannas, A, Ceravolo, Mg, Ceravolo, R, Cicarelli, G, Gaglio, Rm, Giglia, L, Iemolo, F, Manfredi, M, Meco, G, Nicoletti, A, Pederzoli, M, Petrone, A, Pisani, A, Pontieri, Fe, Quatrale, R, Ramat, S, Scala, R, Volpe, G, Zappulla, S, Bentivoglio, Ar, Stocchi, F, Trianni, G, Del Dotto, P, Simoni, L, Marconi, R, and PRIAMO STUDY, G. R. O. U. P.
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Male ,Secondary ,Neurology ,secondary parkinsonism ,parkinson and cognitive impairment ,Neurological disorder ,PRIAMO STUDY ,Orthostatic vital signs ,Prevalence ,Corticobasal degeneration ,Supranuclear Palsy ,Longitudinal Studies ,Parkinsonism ,Cognitive disorder ,Parkinson Disease ,Neurodegenerative Diseases ,Middle Aged ,non-motor symptoms ,atypical parkinsonism ,Italy ,Atypical parkinsonism, Non-motor symptoms, Parkinson and cognitive impairment, Secondary parkinsonism ,epidemiology ,Settore MED/26 - Neurologia ,Female ,Supranuclear Palsy, Progressive ,Lewy Body Disease ,medicine.medical_specialty ,Humans ,Aged ,Parkinson Disease, Secondary ,Cross-Sectional Studies ,Multiple System Atrophy ,Parkinsonian Disorders ,Atypical parkinsonism ,Non-motor symptoms ,Parkinson and cognitive impairment ,Secondary parkinsonism ,Neurology (clinical) ,Aged, Cross-Sectional Studies, Female, Humans, Italy ,epidemiology, Lewy Body Disease ,epidemiology, Longitudinal Studies, Male, Middle Aged, Multiple System Atrophy ,epidemiology, Neurodegenerative Diseases ,epidemiology, Parkinson Disease ,epidemiology, Parkinsonian Disorders ,epidemiology, Prevalence, Supranuclear Palsy ,Progressive ,Progressive supranuclear palsy ,Internal medicine ,mental disorders ,medicine ,Dementia with Lewy bodies ,business.industry ,medicine.disease ,nervous system diseases ,Physical therapy ,business ,PARKINSONISM - Abstract
The PRIAMO study is a cross-sectional longitudinal observational study aimed at describing epidemiology and evolution of non-motor symptoms (NMS) in patients with different forms of parkinsonism recruited in 55 Italian centres and evaluated over 24 months. In this paper, we are reporting prevalence and clinical characteristics of NMS in patients with atypical and secondary parkinsonism. Out of 1307 consecutive patients with a diagnosis of parkinsonism, 83 patients had vascular parkinsonism (VP), 34 had multiple system atrophy (MSA), 30 had progressive supranuclear palsy (PSP), 14 had dementia with Lewy bodies (DLB) and 11 had corticobasal degeneration (CBD). MSA and DLB had the highest number of NMS domains and symptoms, respectively. Gastrointestinal symptoms, pain, urinary problems and postural instability due to orthostatic hypotension were most frequent in MSA. Sleep disturbances were also common with a prevalence of approximately 70% in all diagnostic groups but CBD (36%). Psychiatric symptoms and attention and memory impairment were frequently observed in all diagnoses but were most prevalent among DLB patients, whereas the prevalence of skin and respiratory disorders was rather low in all forms, ranging between 10 and 30%. Atypical parkinsonism patients also reported a low QoL, with no significant differences among the different forms, whereas PD and VP patients had a better QoL.
- Published
- 2009
27. Anhedonia and cognitive impairment in Parkinson's disease: Italian validation of the Snaith-Hamilton Pleasure Scale and its application in the clinical routine practice during the PRIAMO study
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Santangelo, G, Morgante, L, Savica, R, Marconi, R, Grasso, L, Antonini, A, De Gaspari, D, Ottaviani, D, Tiple, D, Simoni, L, Barone, P, Priamo, Sg, Colosimo, C, Benincasa, D, Biguzzi, S, Braga, M, Capecci, M, Caravona, N, De Falco, Fa, Pezzoli, G, Di Giovanni, M, Floris, G, Gallerini, S, Gurgone, G, Kiferle, L, Meoni, S, Moschella, V, Morgante, F, Pepe, F, Petretta, V, Randisi, Mg, Romeno, M, Ianniciello, M, Sciortino, G, Guzzardi, Po, Sorbello, V, Fabbrini, G, Guidubaldi, A, Muoio, R, Toni, V, Ferrari, Po, Logi, C, Ciacci, G, Ulivelli, M, Perini, M, Lanfranchi, S, Griffini, S, Troianiello, B, Baratti, M, Amidei, S, Consoli, D, Iellamo, M, Cuomo, T, Scaglioni, A, Medici, D, Abbruzzese, Giovanni, Di Brigida, G, Cocco, Ga, Agnetti, V, Cossu, G, Deriu, M, Abrignani, M, Modica, C, Albani, G, Milan, E, Martinelli, P, Scaglione, C, Mucchiut, M, Zanini, S, Pennisi, F, Soliveri, P, Albanese, A, Bartolomei, L, L'Erario, R, Capus, L, Ferigo, L, Marano, R, Nastasi, V, Luciano, R, Maiello, L, Simone, P, Fogli, D, Lopiano, L, Pesare, M, Molinette, As, Nordera, G, Pilleri, E, Scaravilli, T, Giaccaglini, E, Alesi, C, Corbetta, T, Dumitriu, A, Ingelheim, B, Sgarbi, S, Rapisarda, A, Rizzoli, S, Zanoli, L, Manfredi, A., Santangelo, Gabriella, Morgante, L, Savica, R, Marconi, R, Grasso, L, Antonini, A, De Gaspari, D, Ottaviani, D, Tiple, D, Simoni, L, Barone, P, PRIAMO Study, Group, Santangelo, G, Barone, Paolo, and PRIAMO Study, G. r. o. u. p.
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Male ,medicine.medical_specialty ,Parkinson's disease ,media_common.quotation_subject ,Multilingualism ,Pilot Projects ,Test validity ,Affect (psychology) ,behavioral disciplines and activities ,Aged, Aged ,80 and over, Cognition Disorders ,diagnosis/epidemiology/psychology, Depressive Disorder ,Major ,diagnosis/epidemiology/psychology, Female, Humans, Italy ,epidemiology, Male, Middle Aged, Multilingualism, Parkinson Disease ,diagnosis/epidemiology/psychology, Pilot Projects, Psychiatric Status Rating Scales ,standards, Reproducibility of Results ,Pleasure ,medicine ,80 and over ,Humans ,Psychiatry ,Depression (differential diagnoses) ,media_common ,Aged ,Aged, 80 and over ,Psychiatric Status Rating Scales ,Depressive Disorder, Major ,Depressive Disorder ,Parkinsonism ,Anhedonia ,Reproducibility of Results ,Parkinson Disease ,Middle Aged ,medicine.disease ,Test (assessment) ,Neurology ,Italy ,standards ,Female ,epidemiology ,Neurology (clinical) ,Geriatrics and Gerontology ,medicine.symptom ,Psychology ,Cognition Disorders ,diagnosis/epidemiology/psychology ,Clinical psychology - Abstract
To assess the psychometric properties of the Italian version of the Snaith-Hamilton Pleasure Scale (SHAPS) and to study the relationship between anhedonia, depression and cognitive impairment in patients with Parkinson's disease (PD).The SHAPS (14 items) was translated into Italian and pre-tested in a pilot study. Two items evaluating physical anhedonia related to sexual issues were added. The Italian version of SHAPS was validated in 274 consecutive PD patients, divided into patients with major depression according to DSM-IV criteria (dPD) and patients without depression (nPD), and in healthy subjects. To test the feasibility of the instrument and to determine whether clinical data affect anhedonia, we also administered SHAPS to 1307 patients with different types of parkinsonism.The Italian SHAPS proved to be easy to understand as regards the question and answer modes. Intraclass coefficient for test-retest reliability was 0.65 for the total score. KR index was 0.61. ANOVA of the SHAPS total score revealed that scores were higher in dPD patients than in healthy controls and nPD (p0.05). In the 1307 patients with various types of parkinsonism, the SHAPS data showed that anhedonia was related to age, type of parkinsonism, apathy, depression and cognitive impairment. Anhedonia was correlated with frontal dysfunctions in supranuclear palsy and PD patients (r=-0.682 and -0.264 respectively, p0.05).The Italian version of the SHAPS is a reliable tool with which to assess anhedonia in patients with PD and other forms of parkinsonism.
- Published
- 2009
28. Low Ankle-brachial index predicts an adverse 1-year outcome after acute coronary and cerebrovascular events
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Agnelli, G., Cimminiello, C., Meneghetti, G., Urbinati, S., Cappielo, E., Bazzi, P., Arpaia, G., Santamaria, M. G., Tassara, R. I., Rebuttato, A. I., Perna, G. P., Gabrielli, D., Ruga, O., Moretti, L., Gregori, G., Marconi, M. K., Burali, A., DE LUCA, I. M., Ciriello, N. M., Ciampa, G. N., Pitscheider, W., Tomaino, M., Poma, E., Poggio, G., Spissu, A., Melis, A., Pinna, L., Lastilla, M., Bonaventura, A. R., Visonà, A. S., Tonello, D. S., Pennisi, G., Bella, R, Santonocito, D., Borrello, G. U., Mazza, M. L., Mattoscio, N., Garzaro, L., Pinneri, F., Zarcone, D., Lanfranchi, S., Moretti, V., Busettini, G., Bordin, P., Delfino, R. Z., Zingarelli, A., Caroppo, E. A., Puccetti, I. A., Orlandi, M., Losi, L., DE CAROLIS, P., Zanini, R., Cionini, F., Viecca, M., Lazzaroni, A., Satta, T., Manenti, V., Basile, G., Tuccillo, B., Accadia, M., Piatto, A., Annunziata, L., Mandarini, A., Androne, V. A., Traccis, S. A., Ottina, M., D'Angelo, A., Fazio, M., Damiani, L. A., Lupo, I., Savettieri, G., DEL PINTO, M., Notaristefano, S., Imberti, D., Tartarin, G., Lucarini, A., Topi, A., D'Anna, S., Saccardi, M., Paciello, M. A., Tordini, G., D'Arienzo, E., Piovaccari, G., Pesaresi, A., Amabile, G., Fiermonte, G., Gallù, M. C., Fontana, L., Ferri, F., Curatola, L., Gobbato, R., Paci, C., Simone, P., DI VIESTI, P., Tonizzo, M., LI VOLSI, P., Gionco, M., Onofri, M., Scorzoni, D., Grimoldi, P., Dentali, F., Ageno, W., Venco, A., and Grillo, G.
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Male ,Brachial Artery ,Myocardial Infarction ,Blood Pressure ,Coronary Disease ,Cohort Studies ,Angina ,Odds Ratio ,Prospective Studies ,Myocardial infarction ,Transient ischemic attack ,Prospective cohort study ,Stroke ,Acute myocardial infarction ,Ankle-brachial index ,Atherosclerosis ,Unstable angina ,Acute Disease ,Aged ,Angina, Unstable ,Ankle ,Cerebrovascular Disorders ,Female ,Follow-Up Studies ,Hospitalization ,Humans ,Ischemic Attack, Transient ,Italy ,Predictive Value of Tests ,Prognosis ,Regression Analysis ,Survival Analysis ,Syndrome ,Hematology ,Ischemic Attack ,Transient ,Predictive value of tests ,cardiovascular system ,Cardiology ,medicine.symptom ,medicine.medical_specialty ,Unstable ,Asymptomatic ,Internal medicine ,medicine ,cardiovascular diseases ,business.industry ,Odds ratio ,medicine.disease ,body regions ,business ,human activities - Abstract
Summary. Background: Low ankle–brachial Index (ABI) identifies patients with symptomatic and asymptomatic peripheral arterial disease. The aim of this study was to correlate ABI value (normal or low) with 1-year clinical outcome in patients hospitalized for acute coronary syndromes or cerebrovascular diseases (CVD). Methods: ABI was measured in consecutive patients hospitalized because of acute myocardial infarction, unstable angina, stroke or transient ischemic attack (TIA). An ABI lower than or equal to 0.90 was considered abnormal. The primary outcome of the study was the composite of non-fatal acute myocardial infarction, non-fatal ischemic stroke, and death from any cause during the year following the index event. Results: An abnormal ABI was found in 27.2% of 1003 patients with acute coronary syndromes, and in 33.5% of 755 patients with acute CVD. After a median follow-up of 372 days, the frequency of the primary outcome was 10.8% (57/526) in patients with abnormal ABI and 5.9% (73/1232) in patients with normal ABI [odds ratio (OR) 1.96; 95% CI 1.36–2.81]. Death was more common in patients with abnormal ABI (OR 2.05; 95% CI 1.31–3.22). Cardiovascular mortality accounted for 81.7% of overall mortality. ABI was predictive of adverse outcome after adjustment for vascular risk factors in the logistic regression analysis (OR 1.93; 95% CI 1.24–3.01). The predictive value of ABI was mainly accounted for by patients hospitalized for acute coronary syndromes (adverse outcome: 12.8% in patients with abnormal ABI and 5.9% in patients with normal ABI, OR 2.35; 95% CI 1.47–3.76). Conclusions: An abnormal ABI can be found in one-third of patients hospitalized for acute coronary or cerebrovascular events and is a predictor of an adverse 1-year outcome.
- Published
- 2006
29. Working memory in Down syndrome: is there a dual task deficit?
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Lanfranchi, S., primary, Baddeley, A., additional, Gathercole, S., additional, and Vianello, R., additional
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- 2011
- Full Text
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30. Asymmetrical reduction of the nociceptive flexion reflex threshold in cluster headache
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Sandrini, G, primary, Antonaci, F, additional, Lanfranchi, S, additional, Milanov, I, additional, Danilov, A, additional, and Nappi, G, additional
- Published
- 2000
- Full Text
- View/download PDF
31. Eye movement abnormalities in myotonic dstrophy
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Versino, M, primary, Romani, A, additional, Bergamaschi, R, additional, Callieco, R, additional, Scolari, S, additional, Poli, R, additional, Lanfranchi, S, additional, Sandrini, G, additional, and Cosi, V, additional
- Published
- 1998
- Full Text
- View/download PDF
32. Saccadic and smooth pursuit eye movements in myotonic dystrophy
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Versino, M., primary, Poli, R., additional, Romani, A., additional, Bergamaschi, R., additional, Lanfranchi, S., additional, Sandrini, G., additional, and Cosi, V., additional
- Published
- 1996
- Full Text
- View/download PDF
33. Italian botulinum toxin network study on the management of spasticity in multiple sclerosis
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Moccia, M., Frau, J., Antonio Carotenuto, Coghe, G., Barbero, P., Frontoni, M., Giovannelli, M., Butera, C., Inglese, C., Frasson, E., Latino, P., Osio, M., Lanfranchi, S., Romano, M., Lori, S., Liotti, V., Rapisarda, L., Patti, F., Esposito, M., Altavista, M. C., Bono, F., Eleopra, R., and Morra, V. Brescia
34. Effectiveness of ibuprofen-arginine in the treatment of acute migraine attacks
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Sandrini, G., Franchini, S., Lanfranchi, S., Granella, F., Manzoni, G. C., and Giuseppe Nappi
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Adult ,Male ,Analysis of Variance ,Chi-Square Distribution ,Cross-Over Studies ,Dose-Response Relationship, Drug ,Migraine Disorders ,Anti-Inflammatory Agents, Non-Steroidal ,Administration, Oral ,Ibuprofen ,Arginine ,Drug Combinations ,Double-Blind Method ,Area Under Curve ,Acute Disease ,Humans ,Female ,Pain Measurement - Abstract
The purpose of this study was to evaluate the effectiveness of a new formulation of ibuprofen (ibuprofen-arginine [IA]) in the treatment of migraine attacks. This is a faster absorbed formulation as compared with ibuprofen alone. The rapidity of action is considered to be a crucial factor in the treatment of migraine attacks. Forty migraine patients participated in this multicenter, double-blind, crossover, randomized, placebo-controlled trial. Each patient was treated with a single oral dose of IA 400 mg or placebo during two consecutive migraine attacks. The results confirm the efficacy of IA, with a significant (p0.05) improvement in pain relief at 30 min after treatment. A statistically significant (p0.001) reduction in pain intensity was observed at 1, 2, 4 and 6 h after treatment with ibuprofen as compared with placebo. IA was well tolerated and our data indicate that this new formulation of ibuprofen is valuable in the treatment of acute migraine attacks.
35. The role of magnesium in the physiopathogenesis of migraine attacks | RUOLO DEL MAGNESIO NELLA FISIOPATOGENESI DELL'ATTACCO EMICRANICO
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Sandrini, G., Lanfranchi, S., ALFREDO COSTA, and Nappi, G.
36. Commenti a «Riflessioni sul funzionamento intellettivo limite o borderline: Proposta per una discussione»
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Vianello, R., GIULIA BALBONI, Cu Belli, R., Lanfranchi, S., Pulina, F., Olivio, M., Saggioro, A., Poletti, M., Sironi, E. M., Frinco, M., Taddei, S., Contena, B., Vio, C., Mene Ghel, M., and Cornoldi, C.
37. As,Possibili fattori causali della cefalea di tipo tensivo. Uno studio caso-controllo
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Sandrini, G., Granella, F., Lanfranchi, S., giorgio maggioni, Manzoni, G. C., and Nappi, G.
38. Pathogenesis of tension headache: role of temporomandibular disorders. A research protocol,La patogenesi delle cefalee di tipo tensivo: ruolo dei disordini cranio-cervico-mandibolari. Protocollo di ricerca
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MARZIA SEGU', Sandrini, G., Lanfranchi, S., and Collesano, V.
39. Cognitive profiles in children and adolescents with Down syndrome
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Sara Onnivello, Francesca Pulina, Chiara Locatelli, Chiara Marcolin, Giuseppe Ramacieri, Francesca Antonaros, Beatrice Vione, Maria Caracausi, Silvia Lanfranchi, Onnivello S., Pulina F., Locatelli C., Marcolin C., Ramacieri G., Antonaros F., Vione B., Caracausi M., and Lanfranchi S.
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Male ,Adolescent ,Science ,Intelligence ,Persons with Mental Disabilities ,Child Behavior ,Vocabulary ,behavioral disciplines and activities ,Article ,Child Development ,Cognition ,Human behaviour ,Psychology ,Humans ,Child ,Multidisciplinary ,Verbal Behavior ,Age Factors ,Adolescent Development ,cognitive profiles, Down syndrome, children, adolescent, phenotype, educational support ,Education of Intellectually Disabled ,Biological Variation, Population ,Adolescent Behavior ,Medicine ,Educational Status ,Female ,Down Syndrome ,Child Language - Abstract
The Down syndrome (DS) phenotype is usually characterized by relative strengths in non-verbal skills and deficits in verbal processing, but high interindividual variability has been registered in the syndrome. The goal of this study was to explore the cognitive profile, considering verbal and non-verbal intelligence, of children and adolescents with DS, also taking into account interindividual variability. We particularly aimed to investigate whether this variability means that we should envisage more than one cognitive profile in this population. The correlation between cognitive profile and medical conditions, parents’ education levels and developmental milestones was also explored. Seventy-two children/adolescents with DS, aged 7–16 years, were assessed with the Wechsler Preschool and Primary Scale of Intelligence-III. Age-equivalent scores were adopted, and Verbal and Non-Verbal indices were obtained for each individual. The cognitive profile of the group as a whole was characterized by similar scores in the verbal and non-verbal domain. Cluster analysis revealed three different profiles, however: one group, with the lowest scores, had the typical profile associated with DS (with higher non-verbal than verbal intelligence); one, with intermediate scores, had greater verbal than non-verbal intelligence; and one, with the highest scores, fared equally well in the verbal and non-verbal domain. Three cognitive profiles emerged, suggesting that educational support for children and adolescents with DS may need to be more specific.
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- 2022
40. Executive functions and adaptive behaviour in individuals with Down syndrome
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Allison Piovesan, Francesca Pulina, S. Colaianni, Beatrice Vione, C. Locatelli, Silvia Lanfranchi, Francesca Antonaros, Sara Onnivello, C. Marcolin, Giuseppe Ramacieri, Onnivello S., Colaianni S., Pulina F., Locatelli C., Marcolin C., Ramacieri G., Antonaros F., Vione B., Piovesan A., and Lanfranchi S.
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behavioural phenotype ,Down syndrome ,Weakness ,Activities of daily living ,Adolescent ,Vineland ,Population ,Emotions ,BRIEF ,Developmental psychology ,Executive Function ,Arts and Humanities (miscellaneous) ,Adaptation, Psychological ,medicine ,Humans ,education ,Child ,Emotion ,education.field_of_study ,Working memory ,Rehabilitation ,Executive functions ,medicine.disease ,Psychiatry and Mental health ,Memory, Short-Term ,adaptive behaviour ,Neurology ,Adaptive behaviour ,Child, Preschool ,Neurology (clinical) ,medicine.symptom ,Down Syndrome ,Psychology ,Strengths and weaknesses ,Human - Abstract
Background: Previous research has explored executive functions (EFs) and adaptive behaviour in children and adolescents with Down syndrome (DS), but there is a paucity of research on the relationship between the two in this population. This study aims to shed light on the profile of EFs and adaptive behaviour in DS, exploring the differences by age and investigating the relationship between these two domains. Method: Parents/caregivers of 100 individuals with DS from 3 to 16years old participated in the study. The sample was divided into preschoolers (3–6.11years old) and school-age children (7–16years old). Parents/caregivers completed either the Preschool Version of the Behaviour Rating Inventory of Executive Function (for children 2–6.11years old) or the Second Edition of the same Inventory (for individuals 7+years old). Adaptive behaviour was assessed with the Vineland Adaptive Behaviour Scale – Interview, Second Edition. Results: Findings suggest that individuals with DS have overall difficulties, but also patterns of strength and weakness in their EFs and adaptive behaviour. The preschool-age and school-age children's EF profiles differed slightly. While both age groups showed Emotional Control as a relative strength and Working Memory as a weakness, the school-age group revealed further weaknesses in Shift and Plan/Organise. As concerns adaptive behaviour, the profiles were similar in the two age groups, with Socialisation as a strength, and Communication and Daily Living Skills as weaknesses, but with a tendency for preschoolers to obtain intermediate scores for the latter. When the relationship between EFs and adaptive behaviour was explored, Working Memory predicted Communication in the younger group, while in the older group the predictors varied, depending on the adaptive domains: Working Memory was a predictor of Communication, Inhibit of Daily Living Skills, and Inhibit and Shift of Socialisation. Conclusion: As well as elucidating the EF profiles and adaptive behaviour in individuals with DS by age, this study points to the role of EFs in adaptive functioning, providing important information for targeted interventions.
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- 2021
41. Is the Age of Developmental Milestones a Predictor for Future Development in Down Syndrome?
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Allison Piovesan, Silvia Lanfranchi, Chiara Marcolin, Gian Luca Pirazzoli, Francesca Pulina, Maria Chiara Pelleri, Chiara Locatelli, Giacomo Sperti, Sara Rossi, Giuseppe Ramacieri, Agnese Feliciello, Giulia Procaccini, Anna Martelli, Maria Caracausi, Renzo Vianello, Sonia Filoni, Lorenza Vitale, Guido Cocchi, Enrico Toffalini, Francesca Antonaros, Sara Onnivello, Pierluigi Strippoli, Locatelli C., Onnivello S., Antonaros F., Feliciello A., Filoni S., Rossi S., Pulina F., Marcolin C., Vianello R., Toffalini E., Ramacieri G., Martelli A., Procaccini G., Sperti G., Caracausi M., Pelleri M.C., Vitale L., Pirazzoli G.L., Strippoli P., Cocchi G., Piovesan A., and Lanfranchi S.
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Down syndrome ,Neurosciences. Biological psychiatry. Neuropsychiatry ,Babbling ,Article ,Developmental psychology ,03 medical and health sciences ,0302 clinical medicine ,Developmental milestone ,Intellectual disability ,medicine ,0501 psychology and cognitive sciences ,development ,Motor skill ,General Neuroscience ,05 social sciences ,Down syndrome, milestones, development ,Cognition ,medicine.disease ,Down Syndrome ,developmental milestones ,Language development ,Age of Acquisition ,Developmental Milestone ,milestones ,Psychology ,030217 neurology & neurosurgery ,RC321-571 ,050104 developmental & child psychology - Abstract
Down Syndrome (DS) is the most common genetic alteration responsible for intellectual disability, which refers to deficits in both intellectual and adaptive functioning. According to this, individuals with Down Syndrome (DS) reach developmental milestones (e.g., sitting, walking, and babbling) in the same order as their typically developing peers, but later in life. Since developmental milestones are the first blocks on which development builds, the aims of the current study are to: (i) expand the knowledge of developmental milestone acquisition; and (ii) explore the relationship between developmental milestone acquisition and later development. For this purpose 105 children/adolescents with DS were involved in this study, divided in two groups, Preschoolers (n = 39) and School-age participants (n = 66). Information on the age of acquisition of Sitting, Walking, Babbling, and Sphincter Control was collected, together with cognitive, motor, and adaptive functioning. Sitting predicted later motor development, but, with age, it became less important in predicting motor development in everyday life. Babbling predicted later language development in older children. Finally, Sphincter Control emerged as the strongest predictor of motor, cognitive, language, and adaptive skills, with its role being more evident with increasing age. Our data suggest that the age of reaching the milestones considered in the study has an influence on successive development, a role that can be due to common neural substrates, the environment, and the developmental cascade effect.
- Published
- 2021
42. The PRIAMO study: age- and sex-related relationship between prodromal constipation and disease phenotype in early Parkinson’s disease
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L Grasso, Silvia Ramat, Simone Gallerini, Paolo Barone, G. Di Brigida, D. Fogli, Tommaso Scaravilli, M. Braga, Alessandra Nicoletti, M. Romeno, Paolo Martinelli, G. Gurgone, Cesare Colosimo, E. Pilleri, V. Sorbello, S. Amidei, F. Pennisi, Francesco Iemolo, Giorgio Trianni, Vincenzo Toni, E. Milan, Raffaele Palladino, D. Benincasa, Giovanni Pezzoli, M. G. Randisi, Alfredo Petrone, Arianna Guidubaldi, R. Alfano, Tania P. Avarello, A. Scaglioni, Anna Rita Bentivoglio, C. Modica, L. Ferigo, M. Manfredi, Domenico Consoli, Giuseppe Meco, Giampiero Volpe, S. Griffini, Francesca Morgante, R. Scala, G. Nordera, Angelo Antonini, G. Floris, Roberto Erro, R. Muoio, Salvatore Zappulla, Luigi Bartolomei, Edo Bottacchi, Antonio Pisani, V. Petretta, Giovanni Fabbrini, G. Ciacci, L. Maiello, G. Ceravolo, M. Di Giovanni, V. Nastasi, Rocco Quatrale, D. Tiple, Marcello Deriu, S. Lanfranchi, Marianna Capecci, Alberto Albanese, T. Cuomo, Francesco E. Pontieri, Vincenzo Moschella, G. Sciortino, F. A. De Falco, S. Biguzzi, Leonardo Lopiano, Marina Picillo, C. Alesi, D. De Gaspari, Michele Abrignani, Gabriella Santangelo, Fabrizio Stocchi, R. Luciano, M. Baratti, R. M. Giglia, Cesa Scaglione, B. Troianiello, Giovanni Abbruzzese, M. Mucchiut, F. Pepe, S. Zanini, L. Capus, N. Caravona, Giovanni Cossu, V. Agnetti, G. Albani, L. Kiferle, E. Giaccaglini, Roberto Marconi, M. Iellamo, R. Marano, D. Medici, Monica Ulivelli, G. A. Cocco, M. Perini, P. Del Dotto, Rosa M. Gaglio, Rodolfo Savica, C. Logi, G. Ciccarelli, P. Massimo, M. Pesare, Antonino Cannas, Roberto Ceravolo, P. Simone, Letterio Morgante, P. Soliveri, S. Meoni, Picillo, M., Palladino, R., Erro, R., Alfano, R., Colosimo, C., Marconi, R., Antonini, A., Barone, P., Morgante, L., Benincasa, D., Quatrale, R., Biguzzi, S., Braga, M., Ceravolo, G., Capecci, M., Meco, G., Caravona, N., Scala, R., De Falco, F. A., Pezzoli, G., De Gaspari, D., Bottacchi, E., Di Giovanni, M., Cannas, A., Floris, G., Gallerini, S., Grasso, L., Gaglio, R. M., Gurgone, G., Volpe, G., Zappulla, S., Ceravolo, R., Kiferle, L., Ramat, S., Meoni, S., Pisani, A., Moschella, V., Morgante, F., Savica, R., Pepe, F., Ciccarelli, G., Petretta, V., Giglia, R. M., Randisi, M. G., Iemolo, F., Avarello, T. P., Romeno, M., Santangelo, G., Stocchi, F., Sciortino, G., Sorbello, V., Nicoletti, A., Tiple, D., Fabbrini, G., Bentivoglio, A., Pontieri, F. E., Guidubaldi, A., Muoio, R., Toni, V., Del Dotto, P., Logi, C., Ciacci, G., Ulivelli, M., Perini, M., Lanfranchi, S., Griffini, S., Troianiello, B., Baratti, M., Amidei, S., Consoli, D., Iellamo, M., Cuomo, T., Scaglioni, A., Medici, D., Manfredi, M., Abbruzzese, G., Di Brigida, G., Cocco, G. A., Agnetti, V., Cossu, G., Deriu, M., Abrignani, M., Modica, C., Albani, G., Milan, E., Martinelli, P., Scaglione, C., Mucchiut, M., Zanini, S., Pennisi, F., Soliveri, P., Albanese, A., Massimo, P., Bartolomei, L., Capus, L., Ferigo, L., Marano, R., Nastasi, V., Luciano, R., Maiello, L., Simone, P., Fogli, D., Lopiano, L., Pesare, M., Nordera, G., Pilleri, E., Scaravilli, T., Giaccaglini, E., Alesi, C., Petrone, A., and Trianni, G.
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Male ,Neurology ,Parkinson's disease ,Constipation ,Heterogeneity ,Parkinson ,Phenotype ,Prodromal ,Sex ,PROGRESSION ,Disease ,0302 clinical medicine ,Apathy ,Neuroradiology ,Original Communication ,Cognition ,Parkinson Disease ,030211 gastroenterology & hepatology ,Female ,medicine.symptom ,NONMOTOR SYMPTOMS ,Life Sciences & Biomedicine ,PRIAMO study group ,Human ,medicine.medical_specialty ,Clinical Neurology ,Prodromal Symptoms ,Prodromal Symptom ,03 medical and health sciences ,Internal medicine ,medicine ,Humans ,Clinical phenotype ,Aged ,Science & Technology ,Neurology & Neurosurgery ,business.industry ,1103 Clinical Sciences ,Biomarker ,medicine.disease ,DYSFUNCTION ,Biomarkers ,Neurology (clinical) ,Neurosciences & Neurology ,business ,1109 Neurosciences ,030217 neurology & neurosurgery - Abstract
Objectives To explore the impact of sex and age on relationship between prodromal constipation and disease phenotype in Parkinson’s disease at early stages. Methods A total of 385 Parkinson’s disease patients from the PRIAMO study were classified according to the presence of prodromal constipation and followed for 24 months. Multivariable mixed-effect models were applied. All analyses were performed separately for sex (64.1% men) and median age (different by sex: 67 years-old in men and 68 years-old in women). Results As for sex, prodromal constipation was associated with greater odds of attention/memory complaints and apathy symptoms in women only. As for age, prodromal constipation was associated with lower cognitive and higher apathy scores in older patients only. Conclusions Prodromal constipation anticipates lower cognitive performances and more severe apathy since the earliest stages in women and older patients. Sex- and age-related heterogeneity of prodromal markers of Parkinson’s disease may impact disease phenotype.
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- 2021
43. Plasma metabolome and cognitive skills in Down syndrome
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Pierluigi Strippoli, Elisa Mannini, Francesca Pulina, Maria Chiara Pelleri, Allison Piovesan, Renzo Vianello, Chiara Locatelli, Silvia Lanfranchi, Francesca Antonaros, Paola Turano, Anna Martelli, Sara Onnivello, Claudio Luchinat, Lorenza Vitale, Guido Cocchi, Agnese Feliciello, Veronica Ghini, Giuseppe Ramacieri, Elena Cicchini, Maria Caracausi, and Antonaros F, Ghini V, Pulina F, Ramacieri G, Cicchini E, Mannini E, Martelli A, Feliciello A, Lanfranchi S, Onnivello S, Vianello R, Locatelli C, Cocchi G, Pelleri MC, Vitale L, Strippoli P, Luchinat C, Turano P, Piovesan A, Caracausi M
- Subjects
Adult ,Male ,Metabolism, cognitive skills, Down syndrome ,Down syndrome ,medicine.medical_specialty ,Magnetic Resonance Spectroscopy ,Adolescent ,Metabolite ,lcsh:Medicine ,Trisomy ,Biochemistry ,Article ,chemistry.chemical_compound ,Plasma ,Young Adult ,cognitive skills ,Metabolomics ,Cognition ,Internal medicine ,Intellectual Disability ,medicine ,Metabolome ,Humans ,Child ,lcsh:Science ,Univariate analysis ,Multidisciplinary ,Intelligence quotient ,Medical genetics ,Neurodevelopmental disorders ,lcsh:R ,Case-control study ,Genomics ,medicine.disease ,Mitochondria ,Chemistry ,Metabolism ,Endocrinology ,chemistry ,Case-Control Studies ,Child, Preschool ,Multivariate Analysis ,Female ,lcsh:Q ,Down Syndrome ,Metabolomics, Genomics, Medical genetics, Neurodevelopmental disorders, Biochemistry, Chemistry - Abstract
Trisomy 21 (Down syndrome, DS) is the main human genetic cause of intellectual disability (ID). Lejeune hypothesized that DS could be considered a metabolic disease, and we found that subjects with DS have a specific plasma and urinary metabolomic profile. In this work we confirmed the alteration of mitochondrial metabolism in DS and also investigated if metabolite levels are related to cognitive aspects of DS. We analyzed the metabolomic profiles of plasma samples from 129 subjects with DS and 46 healthy control (CTRL) subjects by 1H Nuclear Magnetic Resonance (NMR). Multivariate analysis of the NMR metabolomic profiles showed a clear discrimination (up to 94% accuracy) between the two groups. The univariate analysis revealed a significant alteration in 7 metabolites out of 28 assigned unambiguously. Correlations among the metabolite levels in DS and CTRL groups were separately investigated and statistically significant relationships appeared. On the contrary, statistically significant correlations among the NMR-detectable part of DS plasma metabolome and the different intelligence quotient ranges obtained by Griffiths-III or WPPSI-III tests were not found. Even if metabolic imbalance provides a clear discrimination between DS and CTRL groups, it appears that the investigated metabolomic profiles cannot be associated with the degree of ID.
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- 2020
44. Italian normative data for the Unhelpful Thoughts and Beliefs about Stuttering (UTBAS) Scales for adults who stutter.
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Bernardini S, Onnivello S, and Lanfranchi S
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- Humans, Adult, Male, Female, Italy, Reproducibility of Results, Young Adult, Middle Aged, Anxiety psychology, Anxiety etiology, Surveys and Questionnaires standards, Thinking, Psychometrics standards, Psychometrics instrumentation, Adolescent, Stuttering psychology
- Abstract
Purpose: This study aimed to assess the reliability and validity of the Italian translation of the Unhelpful Thoughts and Beliefs about Stuttering (UTBAS) scales for adults who stutter, as there are no assessment tools currently available in Italy. The UTBAS scales provide a comprehensive stuttering-specific measure of the unhelpful thoughts and beliefs that can be used to screen for indicators of social anxiety in adults who stutter. Additionally, the UTBAS scales also allow the identification of negative thoughts and beliefs that negatively impact speech treatment outcomes., Method: The translation of the UTBAS scales into Italian (UTBAS-ITA) was completed using the forward-backward translation process and it was administered to 98 adults who stutter (AWS) and 98 adults who do not stutter (AWNS). Both groups were matched for gender and age. We also administered the UTBAS-ITA to 76 AWS a second time within a two-week interval to assess test-retest reliability. Additionally, we administered the State-Trait Anxiety Inventory and the Fear of Negative Evaluation Scale to 20 AWS to assess concurrent validity., Results: The UTBAS-ITA showed good power of discrimination between AWS and AWNS, high internal validity, high internal consistency, good construct validity, and good test-retest reliability., Conclusion: Since there is a scarcity of clinical assessment tools for adults who stutter in Italy, the UTBAS-ITA could serve as an assessment tool and outcome measure for clinical and research environments., Competing Interests: Declaration of Competing Interest The authors declare no conflict of interest., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
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- 2024
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45. Parent Perspectives on Parent-Mediated Intervention for Young Children With Down Syndrome.
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Walsh MM, Van Deusen K, Pinks ME, Ceci B, Hepburn S, Riggs NR, Pulina F, Marcolin C, Onnivello S, Colaianni S, Gray B, Daunhauer LA, Lanfranchi S, and Fidler DJ
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- Humans, Female, Male, Child, Preschool, Adult, Child, Focus Groups, Infant, Down Syndrome, Parents, Qualitative Research
- Abstract
Background: Parent-mediated intervention (PMI) is a potentially scalable approach for tailored interventions in neurogenetic conditions like Down syndrome (DS). Because PMIs require ongoing parent engagement, they must be developed in alignment with the needs of intended users. The present study examined caregiver opinions and preferences to inform the development of syndrome-informed interventions for children with DS., Method: Parents of children with DS (n = 34) participated in focus groups discussing PMI. Interviews were transcribed and a thematic analysis was applied to code the data., Results: Three themes were identified: advantages of PMI, disadvantages of PMI and preferred features of PMI. To align with parent preferences, future PMIs for children with DS should require a brief time commitment, blend intervention activities into daily routines and include family members in activities., Conclusions: Findings have implications for developing novel interventions to support early development in children with DS and other neurogenetic conditions., (© 2024 The Author(s). Journal of Applied Research in Intellectual Disabilities published by John Wiley & Sons Ltd.)
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- 2024
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46. Weaker number sense accounts for impaired numerosity perception in dyscalculia: Behavioral and computational evidence.
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Dolfi S, Decarli G, Lunardon M, De Filippo De Grazia M, Gerola S, Lanfranchi S, Cossu G, Sella F, Testolin A, and Zorzi M
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- Humans, Child, Female, Male, Visual Perception physiology, Adolescent, Mathematics, Dyscalculia physiopathology, Judgment physiology
- Abstract
Impaired numerosity perception in developmental dyscalculia (low "number acuity") has been interpreted as evidence of reduced representational precision in the neurocognitive system supporting non-symbolic number sense. However, recent studies suggest that poor numerosity judgments might stem from stronger interference from non-numerical visual information, in line with alternative accounts that highlight impairments in executive functions and visuospatial abilities in the etiology of dyscalculia. To resolve this debate, we used a psychophysical method designed to disentangle the contribution of numerical and non-numerical features to explicit numerosity judgments in a dot comparison task and we assessed the relative saliency of numerosity in a spontaneous categorization task. Children with dyscalculia were compared to control children with average mathematical skills matched for age, IQ, and visuospatial memory. In the comparison task, the lower accuracy of dyscalculics compared to controls was linked to weaker encoding of numerosity, but not to the strength of non-numerical biases. Similarly, in the spontaneous categorization task, children with dyscalculia showed a weaker number-based categorization compared to the control group, with no evidence of a stronger influence of non-numerical information on category choice. Simulations with a neurocomputational model of numerosity perception showed that the reduction of representational resources affected the progressive refinement of number acuity, with little effect on non-numerical bias in numerosity judgments. Together, these results suggest that impaired numerosity perception in dyscalculia cannot be explained by increased interference from non-numerical visual cues, thereby supporting the hypothesis of a core number sense deficit. RESEARCH HIGHLIGHTS: A strongly debated issue is whether impaired numerosity perception in dyscalculia stems from a deficit in number sense or from poor executive and visuospatial functions. Dyscalculic children show reduced precision in visual numerosity judgments and weaker number-based spontaneous categorization, but no increasing reliance on continuous visual properties. Simulations with deep neural networks demonstrate that reduced neural/computational resources affect the developmental trajectory of number acuity and account for impaired numerosity judgments. Our findings show that weaker number acuity in developmental dyscalculia is not necessarily related to increased interference from non-numerical visual cues., (© 2024 The Author(s). Developmental Science published by John Wiley & Sons Ltd.)
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- 2024
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47. Cross-sectional developmental trajectories in the adaptive functioning of children and adolescents with Down syndrome.
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Onnivello S, Locatelli C, Pulina F, Ramacieri G, Marcolin C, Antonaros F, Vione B, Catapano F, and Lanfranchi S
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- Child, Humans, Adolescent, Child, Preschool, Cross-Sectional Studies, Intelligence, Communication, Socialization, Down Syndrome
- Abstract
Background: Persons with Down syndrome (DS) reveal adaptive functioning (AF) difficulties. Studies on AF in DS have focused mainly on describing the profile (i.e., strengths in socialization, and weaknesses in communication), while less is known about age-related differences. This study aimed to elucidate how AF changes with age in children and adolescents with DS, taking a cross-sectional developmental trajectory approach. Moreover, the contribution of both chronological age (CA) and mental age (MA) on AF development was explored., Method: This study involved 115 children and adolescents (between 3 and 16 years old) with DS. Parents were interviewed about their children's AF on communication, daily living and socialization skills. Children and adolescents with DS were assessed on their developmental level., Results: While participants' standard scores on AF decreased linearly over time, their age-equivalent scores increased with linear or segmented patterns, depending on the skill considered. CA and MA were related to daily living skills and socialization to much the same degree, while MA correlated more strongly than CA with communication., Conclusion: This study contributes to the understanding of how AF develops in children and adolescents with DS, showing that CA and MA both contribute to shaping the skills involved., (Copyright © 2023. Published by Elsevier Ltd.)
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- 2024
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48. Machine learning based analysis for intellectual disability in Down syndrome.
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Baldo F, Piovesan A, Rakvin M, Ramacieri G, Locatelli C, Lanfranchi S, Onnivello S, Pulina F, Caracausi M, Antonaros F, Lombardi M, and Pelleri MC
- Abstract
Down syndrome (DS) or trisomy 21 is the most common genetic cause of intellectual disability (ID), but a pathogenic mechanism has not been identified yet. Studying a complex and not monogenic condition such as DS, a clear correlation between cause and effect might be difficult to find through classical analysis methods, thus different approaches need to be used. The increased availability of big data has made the use of artificial intelligence (AI) and in particular machine learning (ML) in the medical field possible. The purpose of this work is the application of ML techniques to provide an analysis of clinical records obtained from subjects with DS and study their association with ID. We have applied two tree-based ML models (random forest and gradient boosting machine) to the research question: how to identify key features likely associated with ID in DS. We analyzed 109 features (or variables) in 106 DS subjects. The outcome of the analysis was the age equivalent (AE) score as indicator of intellectual functioning, impaired in ID. We applied several methods to configure the models: feature selection through Boruta framework to minimize random correlation; data augmentation to overcome the issue of a small dataset; age effect mitigation to take into account the chronological age of the subjects. The results show that ML algorithms can be applied with good accuracy to identify variables likely involved in cognitive impairment in DS. In particular, we show how random forest and gradient boosting machine produce results with low error (MSE <0.12) and an acceptable R
2 (0.70 and 0.93). Interestingly, the ranking of the variables point to several features of interest related to hearing, gastrointestinal alterations, thyroid state, immune system and vitamin B12 that can be considered with particular attention for improving care pathways for people with DS. In conclusion, ML-based model may assist researchers in identifying key features likely correlated with ID in DS, and ultimately, may improve research efforts focused on the identification of possible therapeutic targets and new care pathways. We believe this study can be the basis for further testing/validating of our algorithms with multiple and larger datasets., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2023 The Authors.)- Published
- 2023
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49. The Structure of Working Memory and Its Relationship with Intelligence in Japanese Children.
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Ikeda Y, Kita Y, Oi Y, Okuzumi H, Lanfranchi S, Pulina F, Mammarella IC, Allen K, and Giofrè D
- Abstract
There is a host of research on the structure of working memory (WM) and its relationship with intelligence in adults, but only a few studies have involved children. In this paper, several different WM models were tested on 170 Japanese school children (from 7 years and 5 months to 11 years and 6 months). Results showed that a model distinguishing between modalities (i.e., verbal and spatial WM) fitted the data well and was therefore selected. Notably, a bi-factor model distinguishing between modalities, but also including a common WM factor, presented with a very good fit, but was less parsimonious. Subsequently, we tested the predictive power of the verbal and spatial WM factors on fluid and crystallized intelligence. Results indicated that the shared contribution of WM explained the largest portion of variance of fluid intelligence, with verbal and spatial WM independently explaining a residual portion of the variance. Concerning crystallized intelligence, however, verbal WM explained the largest portion of the variance, with the joint contribution of verbal and spatial WM explaining the residual part. The distinction between verbal and spatial WM could be important in clinical settings (e.g., children with atypical development might struggle selectively on some WM components) and in school settings (e.g., verbal and spatial WM might be differently implicated in mathematical achievement).
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- 2023
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50. Developmental profiles of young children with autism spectrum disorder and global developmental delay: A study with the Griffiths III scales.
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Taddei M, Bulgheroni S, Toffalini E, Pantaleoni C, and Lanfranchi S
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- Humans, Child, Preschool, Child, Developmental Disabilities, Communication, Emotions, Language, Autism Spectrum Disorder
- Abstract
The purpose of this study was to identify developmental profiles associated with autism spectrum disorder (ASD) and global developmental delay (DD) in pre-school aged Italian children. Developmental profiles were evaluated by means of a standardized tool widely used for the assessment of psychomotor development in early childhood, the Griffiths III scales, recently adapted and standardized for the Italian population. Specifically, we compared the Griffiths III profiles of children with ASD and DD (ASD + DD) with those of children with DD alone. Moreover, we inspected the psychometric function of single items by comparing children with ASD + DD and children with DD with typically developing (TD) children from the Griffiths III normative sample. In this way, we aimed to isolate the effects of each diagnostic class on psychomotor abilities and on the psychometric function of single items. The ASD + DD and DD groups were found to share the presence of lower age equivalent scores relative to their chronological age in all the developmental domains considered: Foundations of Learning, Language and Communication, Eye and Hand Coordination, Personal-Social-Emotional and Gross Motor Skills. However, the DD group displayed a homogeneous profile with similar levels of delay in all developmental domains, while children with ASD + DD exhibited relative weaknesses in the Language and Communication and Personal-Social-Emotional scales. The analysis of the psychometric function drawn for each item has confirmed different profiles in social-communicative and non-verbal items between the two diagnostic groups and in relation to TD normative sample. The Griffiths III is a valid psychometric tool for identifying atypical developmental profiles and its use may be recommended during the diagnostic process of ASD and DD, to detect specific strengths and weaknesses and guide person-centered treatment., (© 2023 The Authors. Autism Research published by International Society for Autism Research and Wiley Periodicals LLC.)
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- 2023
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