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3. Illness Phase as a Key Assessment and Intervention Window for Psychosis

Author

D'Souza, Deepak, Srihari, Vinod, Gueorguieva, Ralitza, Patel, Prashant, Forselius-Bielen, Kimberlee, Lu, Jing, Butler, Audrey, Fram, Geena, Afriyie-Agyemang, Yvette, Selloni, Alexandria, Cadavid, Laura, Gomez-Luna, Sandra, Gupta, Aarti, Radhakrishnan, Rajiv, Rashid, Ali, Aker, Ryan, Abrahim, Philisha, Nia, Anahita Bassir, Surti, Toral, Kegeles, Lawrence S., Carlson, Marlene, Goldberg, Terry, Gangwisch, James, Benedict, Erinne, Govil, Preetika, Brazis, Stephanie, Mayer, Megan, Garrigue, Nathalie de la, Fallon, Natalka, Baumvoll, Topaz, Abeykoon, Sameera, Perlman, Greg, Bobchin, Kelly, Elliott, Mark, Schmidt, Lyndsay, Rush, Sage, Port, Allison, Heffernan, Zac, Laney, Nina, Kantor, Jenna, Hohing, Thomas, Kohler, Christian G., Wolf, Daniel H., Abi-Dargham, Anissa, Anticevic, Alan, Cho, Youngsun T., Fonteneau, Clara, Gil, Roberto, Girgis, Ragy R., Gray, David L., Grinband, Jack, Javitch, Jonathan A., Kantrowitz, Joshua T., Krystal, John H., Lieberman, Jeffrey A., Murray, John D., Ranganathan, Mohini, Santamauro, Nicole, Van Snellenberg, Jared X., Tamayo, Zailyn, Gur, Ruben C., Gur, Raquel E., and Calkins, Monica E.

Published
2023
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7. Observations of Positive Parenting from Online Parent–Child Interactions at Age 1.

Author

Waller, Rebecca, Paz, Yael, Himes, Megan M., White, Lauren K., Rodriguez, Yuheiry, Gorgone, Alesandra, Luby, Joan, Gerstein, Emily D., Brady, Rebecca G., Chaiyachati, Barbara H., Duncan, Andrea F., Barzilay, Ran, Kornfield, Sara L., Burris, Heather H., Seidlitz, Jakob, Parish-Morris, Julia, Laney, Nina, Gur, Raquel E., and Njoroge, Wanjikũ F. M.

Subjects
POSITIVE psychology, INTERNET, CHILD development, MEDICAL care, PARENTING, DESCRIPTIVE statistics, RESEARCH funding, PARENT-child relationships, COVID-19 pandemic
Abstract

Objective. Brief, reliable, and cost-effective methods to assess parenting are critical for advancing parenting research. Design. We adapted the Three Bags task and Parent Child Interaction Rating System (PCIRS) for rating online visits with 219 parent–child dyads (White, n = 104 [47.5%], Black, n = 115 [52.5%]) and combined the video data with survey data collected during pregnancy and when children were aged 1. Results. The PCIRS codes of positive regard, stimulation of child cognitive development, and sensitivity showed high reliability across the three parent–child interaction tasks. A latent positive parenting factor combining ratings across codes and tasks showed good model fit, which was similar regardless of parent self-identified race or ethnicity, age, socioeconomic disadvantage, marital/partnered status, and parity, as well as methodological factors relevant to the online video assessment method (e.g., phone vs. laptop/tablet). In support of construct validity, observed positive parenting was related to parent-reported positive parenting and child socioemotional development. Finally, parent reports of supportive relationships in pregnancy but not neighborhood safety or pandemic worries, were prospectively related to higher positive parenting observed at age 1. With the exception of older parental age and married/partnered status, no other parent, child, sociodemographic, or methodological variables were related to higher overall video exclusions across tasks. Conclusions. PCIRS may provide a reliable approach to rate positive parenting at age 1, providing future avenues for developing more ecologically valid assessments and implementing interventions through online encounters that may be more acceptable, accessible, or preferred among parents of young children. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Depression and neurocognitive dysfunction in pediatric and young adult chronic kidney disease

Author

Kogon, Amy J., Kim, Ji Young, Laney, Nina, Radcliffe, Jerilynn, Hooper, Stephen R., Furth, Susan L., and Hartung, Erum A.

Subjects
Chronic kidney failure -- Complications and side effects -- Patient outcomes, Depression, Mental -- Risk factors, Pediatric research, Health
Abstract

Background Depression affects 7-35% of children with chronic kidney disease (CKD), and in adults with CKD, the presence of depression links to poorer medical outcomes, social functioning difficulties, and neurocognitive impairments. The relationship between depression and neurocognitive function in youth with CKD is unclear. We sought to identify factors associated with depression in youth with CKD and to determine whether depression affects neurocognitive performance. Methods We conducted cross-sectional analyses in 71 CKD and 64 control participants aged 8 to 25 years who completed depression inventories and neurocognitive assessments as part of the Neurocognitive Assessment and Magnetic Resonance Imaging Analysis of Children and Young Adults with CKD Study. In the CKD group, multivariable logistic regression analysis determined associations between clinical and demographic factors and depression. In the full study cohort, multivariable linear regression analyses, including an interaction term between CKD status and depression evaluated the effect of depression on 11 neurocognitive outcome domains. Results Obesity significantly associated with depression in the CKD group (OR 10.25, P = 0.01). In adjusted analyses, depressed youth with CKD scored worse than non-depressed CKD participants by 0.6-1.0 standard deviations in 5 neurocognitive domains: attention, visual memory, visual-spatial, visual working memory, and problem solving. Conclusions CKD youth with obesity are more likely to be depressed, and those who are depressed exhibit worse neurocognitive performance. Depression may represent a therapeutic target to improve neurocognitive performance in youth with CKD., Author(s): Amy J. Kogon [sup.1] [sup.2] , Ji Young Kim [sup.3] , Nina Laney [sup.4] , Jerilynn Radcliffe [sup.2] [sup.5] , Stephen R. Hooper [sup.6] , Susan L. Furth [sup.1] [...]

Published
2019
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13. Illness Phase as a Key Assessment and Intervention Window for Psychosis

Author

Kohler, Christian G., Wolf, Daniel H., Abi-Dargham, Anissa, Anticevic, Alan, Cho, Youngsun T., Fonteneau, Clara, Gil, Roberto, Girgis, Ragy R., Gray, David L., Grinband, Jack, Javitch, Jonathan A., Kantrowitz, Joshua T., Krystal, John H., Lieberman, Jeffrey A., Murray, John D., Ranganathan, Mohini, Santamauro, Nicole, Van Snellenberg, Jared X., Tamayo, Zailyn, D'Souza, Deepak, Srihari, Vinod, Gueorguieva, Ralitza, Patel, Prashant, Forselius-Bielen, Kimberlee, Lu, Jing, Butler, Audrey, Fram, Geena, Afriyie-Agyemang, Yvette, Selloni, Alexandria, Cadavid, Laura, Gomez-Luna, Sandra, Gupta, Aarti, Radhakrishnan, Rajiv, Rashid, Ali, Aker, Ryan, Abrahim, Philisha, Nia, Anahita Bassir, Surti, Toral, Kegeles, Lawrence S., Carlson, Marlene, Goldberg, Terry, Gangwisch, James, Benedict, Erinne, Govil, Preetika, Brazis, Stephanie, Mayer, Megan, Garrigue, Nathalie de la, Fallon, Natalka, Baumvoll, Topaz, Abeykoon, Sameera, Perlman, Greg, Bobchin, Kelly, Elliott, Mark, Schmidt, Lyndsay, Rush, Sage, Port, Allison, Heffernan, Zac, Laney, Nina, Kantor, Jenna, Hohing, Thomas, Gur, Ruben C., Gur, Raquel E., and Calkins, Monica E.

Abstract

The phenotype of schizophrenia, regardless of etiology, represents the most studied psychotic disorder with respect to neurobiology and distinct phases of illness. The early phase of illness represents a unique opportunity to provide effective and individualized interventions that can alter illness trajectories. Developmental age and illness stage, including temporal variation in neurobiology, can be targeted to develop phase-specific clinical assessment, biomarkers, and interventions. We review an earlier model whereby an initial glutamate signaling deficit progresses through different phases of allostatic adaptation, moving from potentially reversible functional abnormalities associated with early psychosis and working memory dysfunction, and ending with difficult-to-reverse structural changes after chronic illness. We integrate this model with evidence of dopaminergic abnormalities, including cortical D1dysfunction, which develop during adolescence. We discuss how this model and a focus on a potential critical window of intervention in the early stages of schizophrenia impact the approach to research design and clinical care. This impact includes stage-specific considerations for symptom assessment as well as genetic, cognitive, and neurophysiological biomarkers. We examine how phase-specific biomarkers of illness phase and brain development can be incorporated into current strategies for large-scale research and clinical programs implementing coordinated specialty care. We highlight working memory and D1dysfunction as early treatment targets that can substantially affect functional outcome.

Published
2023
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14. Illness Phase as a Key Assessment and Intervention Window for Psychosis

Author

Kohler, Christian G., primary, Wolf, Daniel H., additional, Abi-Dargham, Anissa, additional, Anticevic, Alan, additional, Cho, Youngsun T., additional, Fonteneau, Clara, additional, Gil, Roberto, additional, Girgis, Ragy R., additional, Gray, David L., additional, Grinband, Jack, additional, Javitch, Jonathan A., additional, Kantrowitz, Joshua T., additional, Krystal, John H., additional, Lieberman, Jeffrey A., additional, Murray, John D., additional, Ranganathan, Mohini, additional, Santamauro, Nicole, additional, Van Snellenberg, Jared X., additional, Tamayo, Zailyn, additional, Gur, Ruben C., additional, Gur, Raquel E., additional, Calkins, Monica E., additional, D'Souza, Deepak, additional, Srihari, Vinod, additional, Gueorguieva, Ralitza, additional, Patel, Prashant, additional, Forselius-Bielen, Kimberlee, additional, Lu, Jing, additional, Butler, Audrey, additional, Fram, Geena, additional, Afriyie-Agyemang, Yvette, additional, Selloni, Alexandria, additional, Cadavid, Laura, additional, Gomez-Luna, Sandra, additional, Gupta, Aarti, additional, Radhakrishnan, Rajiv, additional, Rashid, Ali, additional, Aker, Ryan, additional, Abrahim, Philisha, additional, Nia, Anahita Bassir, additional, Surti, Toral, additional, Kegeles, Lawrence S., additional, Carlson, Marlene, additional, Goldberg, Terry, additional, Gangwisch, James, additional, Benedict, Erinne, additional, Govil, Preetika, additional, Brazis, Stephanie, additional, Mayer, Megan, additional, Garrigue, Nathalie de la, additional, Fallon, Natalka, additional, Baumvoll, Topaz, additional, Abeykoon, Sameera, additional, Perlman, Greg, additional, Bobchin, Kelly, additional, Elliott, Mark, additional, Schmidt, Lyndsay, additional, Rush, Sage, additional, Port, Allison, additional, Heffernan, Zac, additional, Laney, Nina, additional, Kantor, Jenna, additional, and Hohing, Thomas, additional

Published
2022
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15. Development of Iron Status During Youth: Associations with Sex, Neighborhood Socioeconomic Status, Cognitive Performance, And Brain Structure

Author

Larsen, Bart, primary, Baller, Erica Berlin, additional, Calkins, Monica E., additional, Laney, Nina, additional, Moore, Tyler M., additional, Roalf, David. R., additional, Ruparel, Kosha, additional, Gur, Ruben C., additional, Gur, Raquel E., additional, Georgieff, Michael K., additional, and Satterthwaite, Theodore D., additional

Published
2022
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24. Design and methods of the NiCK study: neurocognitive assessment and magnetic resonance imaging analysis of children and young adults with chronic kidney disease

Author

Hartung, Erum A, primary, Laney, Nina, additional, Kim, Ji Young, additional, Ruebner, Rebecca L, additional, Detre, John A, additional, Liu, Hua-Shan, additional, Davatzikos, Christos, additional, Erus, Guray, additional, Doshi, Jimit J, additional, Schultz, Robert T, additional, Herrington, John D, additional, Jawad, Abbas F, additional, Moodalbail, Divya G, additional, Gur, Ruben C, additional, Port, Allison M, additional, Radcliffe, Jerilynn, additional, Hooper, Stephen R, additional, and Furth, Susan L, additional

Published
2015
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25. Software Robotics - A Haven In A Perfect Virtual Storm?

Author

Laney, Nina

Subjects
Computer software industry -- Laws, regulations and rules, Robotics industry -- Laws, regulations and rules, Pensions -- Laws, regulations and rules, Robotics -- Laws, regulations and rules, Government regulation, Robotics industry, Business, international
Abstract

A perfect storm is in full swing in the Life and Pensions sector - and, gladly, I don't mean this winter's extreme weather. This storm is virtual (literally), formed over [...]

Published
2014

26. MailBag.

Author

Vassalotti, Linda, Reeves, Kathy, Quinn, Karen L., Genier, Traci Trottier, Kaphan, Robin, Nieuwlandt, Pamela, Chonko, Donielle, Laney, Nina, Vermeire, Sara, Bloom, Debi, and Colnes, Laura L.

Subjects
LETTERS to the editor, CELEBRITIES
Abstract

Presents several letters to the editor about articles appearing in previous issues of "People."

Published
2004

27. MailBag.

Author

Sloan, Elaine, Schenider, Tracy, Presas, LouAnn, Mullins, Matt, Fudim, Sherry, Koerner, Corey, Rosenblum, Jan, Butler, Kathleen C., Landis, James, Tunger, Christina, Laney, Nina, and Slavich, Tanya

Subjects
LETTERS to the editor, SUICIDE
Abstract

Presents several letters to the editor from readers in response to articles previously appearing in "People." Topics discussed, including Roy Horn, Eric Benèt, suicide, Rush Limbaugh, and Clay Aiken.

Published
2003

28. The Influence of Pandemic-Related Worries During Pregnancy on Child Development at 12 Months.

Author

White LK, Himes MM, Waller R, Njoroge WFM, Chaiyachati BH, Barzilay R, Kornfield SL, Burris HH, Seidlitz J, Parish-Morris J, Brady RG, Gerstein ED, Laney N, Gur RE, and Duncan A

Abstract

The COVID-19 pandemic has been linked to increased risk for perinatal anxiety and depression among parents, as well as negative consequences for child development. Less is known about how worries arising from the pandemic during pregnancy are related to later child development, nor if resilience factors buffer negative consequences. The current study addresses this question in a prospective longitudinal design. Data was collected from a sub-study ( n  = 184) of a longitudinal study of pregnant individuals (total n  = 1,173). During pregnancy (April 17-July 8, 2020) and the early postpartum period (August 11, 2020-March 2, 2021), participants completed online surveys. At 12 months postpartum (June 17, 2021-March 23, 2022), participants completed online surveys and a virtual laboratory visit, which included parent-child interaction tasks. We found more pregnancy-specific pandemic worries were prospectively related to lower levels of child socioemotional development based on parent report (B=-1.13, SE = .43, p  = .007) and observer ratings (B=-0.13, SE = .07, p  = .045), but not to parent-reported general developmental milestones. Parental emotion regulation in the early postpartum period moderated the association between pregnancy-specific pandemic worries and child socioemotional development such that pregnancy-specific pandemic worries did not related to worse child socioemotional development among parents with high (B=-.02, SE = .10, t=-.14, p = .89) levels of emotion regulation. Findings suggest the negative consequences of parental worry and distress during pregnancy on the early socioemotional development of children in the context of the COVID-19 pandemic. Results highlight that parental emotion regulation may represent a target for intervention to promote parental resilience and support optimized child development.

Published
2023
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29. Evaluation of Neurocognition in Youth with CKD Using a Novel Computerized Neurocognitive Battery.

Author

Hartung EA, Kim JY, Laney N, Hooper SR, Radcliffe J, Port AM, Gur RC, and Furth SL

Subjects
Adolescent, Adult, Cross-Sectional Studies, Executive Function, Female, Glomerular Filtration Rate, Humans, Male, Cognition, Neuropsychological Tests, Renal Insufficiency, Chronic psychology
Abstract

Background and Objectives: Neurocognitive problems in CKD are well documented; time-efficient methods are needed to assess neurocognition in this population. We performed the first study of the efficient 1-hour Penn Computerized Neurocognitive Battery (CNB) in children and young adults with CKD., Design, Setting, Participants, & Measurements: We administered the Penn CNB cross-sectionally to individuals aged 8-25 years with stage 2-5 CKD (n=92, enrolled from three academic nephrology practices from 2011 to 2014) and matched healthy controls (n=69). We analyzed results from 12 tests in four domains: executive control, episodic memory, complex cognition, and social cognition. All tests measure accuracy and speed; we converted raw scores to age-specific z-scores on the basis of Philadelphia Neurodevelopmental Cohort (n=1790) norms. We analyzed each test in a linear regression with accuracy and speed z-scores as dependent variables and with (1) CKD versus control or (2) eGFR as explanatory variables, adjusted for race, sex, and maternal education., Results: Patients with CKD (mean±SD eGFR, 48±25 ml/min per 1.73 m(2); mean age, 16.3±3.9 years) and controls (mean eGFR, 98±20 ml/min per 1.73 m(2); mean age, 16.0±4.0 years) were similar demographically. CKD participants had lower accuracy than controls in tests of complex cognition, with moderate to large effect sizes: -0.53 (95% confidence interval [95% CI], -0.87 to -0.19) for verbal reasoning, -0.52 (95% CI, -0.83 to -0.22) for nonverbal reasoning, and -0.64 (95% CI, -0.99 to -0.29) for spatial processing. For attention, patients with CKD had lower accuracy (effect size, -0.35 [95% CI, -0.67 to -0.03]) but faster response times (effect size, 0.44 [95% CI, 0.04 to 0.83]) than controls, perhaps reflecting greater impulsivity. Lower eGFR was associated with lower accuracy for complex cognition, facial and visual memory, and emotion identification tests., Conclusions: CKD is associated with lower accuracy in tests of complex cognition, attention, memory, and emotion identification, which related to eGFR. These findings are consistent with traditional neurocognitive testing in previous studies., (Copyright © 2016 by the American Society of Nephrology.)

Published
2016
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