71 results on '"Lane KL"'
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2. Working together: collaboration between midwives and doctors in public hospitals.
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Reiger KM and Lane KL
- Abstract
While collaborative, multidisciplinary teamwork is widely espoused as the goal of contemporary hospitals, it is hard to achieve. In maternity care especially, professional rivalries and deep-seated philosophical differences over childbirth generate significant tensions. This article draws on qualitative research in several Victorian public maternity units to consider the challenges to inter-professional collaboration. It reports what doctors and midwives looked for in colleagues they liked to work with -- the attributes of a 'good doctor' or a 'good midwife'. Although their ideals did not entirely match, both groups respected skill and hard work and sought mutual trust, respect and accountability. Yet effective working together is limited both by tensions over role boundaries and power and by incivility that is intensified by increasing workloads and a fragmented labour force. The skills and qualities that form the basis of 'professional courtesy' need to be recognised as essential to good collaborative practice. [ABSTRACT FROM AUTHOR]
- Published
- 2009
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3. Student Risk Screening Scale: initial evidence for score reliability and validity at the high school level.
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Lane KL, Kalberg JR, Parks RJ, and Carter EW
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This article presents findings from a study of the reliability and validity of the Student Risk Screening Scale for use with high school students (N = 674). Results revealed high internal consistency, test-retest stability, interrater reliability, and convergent validity with the Strengths and Difficulties Questionnaire . Predictive validity was established across two academic years, with students at low risk for antisocial behavior differentiated on behavioral (office discipline referrals [ODR]) and academic variables (grade point average [GPA]) from students with moderate and high levels of risk. However, neither ODR nor GPA variables could differentiate between students with moderate-risk or high-risk status. Limitations and future research directions are discussed. [ABSTRACT FROM AUTHOR]
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- 2008
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4. Lyme Disease
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Parker Jc and Lane Kl
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Adult ,medicine.medical_specialty ,Time Factors ,Disease ,Diagnosis, Differential ,Ticks ,Lyme disease ,Borrelia ,Animals ,Humans ,Medicine ,Borrelia burgdorferi ,Child ,Organ system ,Lyme Disease ,biology ,business.industry ,General Medicine ,bacterial infections and mycoses ,biology.organism_classification ,medicine.disease ,Dermatology ,Anti-Bacterial Agents ,Specific antibody ,Antibiotic Agents ,Arachnid Vectors ,Seasons ,business ,Cardiac symptoms - Abstract
Lyme disease, a tick-borne infection caused by the spirochete Borrelia burgdorferi, involves many organ systems. Three clinical stages of involvement have been described; patients with the disease may have cutaneous, arthritic, neurologic, or cardiac symptoms, or a constellation of manifestations. Specific antibody testing and antibiotic agents are available for Lyme disease, but a high index of suspicion must be exercised to recognize atypical manifestations.
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- 1989
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5. Extending the rigor, relevance, and reach of remedial and special education.
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Lane KL and Carter EW
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- 2010
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6. Revisiting the Percentage of K-12 Students in Need of Preventive Interventions in Schools in a "Peri-COVID" Era: Implications for the Implementation of Tiered Programming.
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Weist MD, Garbacz A, Schultz B, Bradshaw CP, and Lane KL
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- Humans, Child, Students, School Health Services organization & administration, Adolescent, Schools, COVID-19 prevention & control, COVID-19 epidemiology, SARS-CoV-2
- Abstract
As the public health framework has been implemented in schools through multi-tiered systems of support, as in Positive Behavioral Interventions and Supports (PBIS), a prominent interpretation has been that 80% of students will benefit from universal or Tier 1 schoolwide behavior support, around 15% will require added selective or Tier 2 targeted support, and 5% will require the more intensive selective or Tier 3 intervention. The PBIS framework also emphasizes the use of tiered logic, with strengthened efforts at the universal and selective levels when student behavioral or mental health needs exceed expected levels. The prediction that 5% of students will require indicated support was based mostly on students at risk for discipline encounters (i.e., office discipline referral data) and, more recently, systematic screening data, but this percentage remains an interpretation of the public health framework. Further, epidemiologic data over the past decade show that rates of childhood mental health disorders have risen and are even higher now as schools struggle to recover from the COVID-19 pandemic-much higher than 15% and 5% for selective and indicated levels. Thus, we believe it is time to revisit projections of the number of students in need of Tier 2 and Tier 3 support. In this position paper, we review the evidence for escalating youth mental health needs and discuss the implications for the tiered prevention framework in schools. We describe strategies to expand the availability of preventive intervention supports beyond Tier 1 efforts and conclude with recommendations for practice, policy, and research in this peri-COVID recovery era., (© 2023. Society for Prevention Research.)
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- 2024
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7. Introduction to the Special Feature, Part 2: Enabling and Implementing Threat Agnostic Approaches to Biodefense and Public Health.
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Lancaster MJ, Adalja AA, and Warmbrod KL
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- Humans, Bioterrorism prevention & control, Public Health, Civil Defense
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- 2024
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8. Introduction to the Special Feature: Threat Agnostic Approaches to Biodefense and Public Health Are Now a Reality.
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Adalja AA, Warmbrod KL, and Lancaster MJ
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- Humans, Biological Warfare Agents, Public Health
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- 2024
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9. A Modular-Incremental Approach to Improving Compliance Verification With the Biological Weapons Convention.
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Cropper NR, Rath S, Teo RJC, Warmbrod KL, and Lancaster MJ
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- Humans, International Cooperation, Biological Warfare Agents, Biological Warfare prevention & control
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- 2023
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10. Exploring tattoo artists' understanding of decorative non-medical professional tattooing as a method of scar camouflage and decoration.
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Moulton KL
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- Humans, Cicatrix, Research Design, Tattooing
- Abstract
Research surrounding the use of decorative tattooing by non-medical professional tattooists as a form of scar camouflage or decoration is limited. This study provides critical and deepening insights into tattoo artists' experiences of tattooing scars, to help inform a more in-depth understanding of its uses from a health and wellbeing perspective. Specifically, it aimed to explore qualitatively, the different methods and techniques used by non-medical tattoo professionals to cover up or decorate scars, which can have a psychological impact on those affected. Six tattoo artists from legitimate UK based studios were identified through snowballing and purposive sampling methods. Data collection involved semi-structured telephone interviews. The data was then transcribed, and thematic analysis was then performed. Five themes were identified: Personal Opinion of Scar Camouflage Tattooing, Tattooing Methods, Scars and Tattooing Risks, Positive Impact, and Understanding of Customer Experience. These themes were then broken down into more specific sub-themes. The discussion considers these findings in relation to theory and existing literature, for example, around understanding of role, and makes recommendations for future study in this field.
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- 2023
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11. Analysis of the first genetic engineering attribution challenge.
- Author
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Crook OM, Warmbrod KL, Lipstein G, Chung C, Bakerlee CW, McKelvey TG Jr, Holland SR, Swett JL, Esvelt KM, Alley EC, and Bradshaw WJ
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- Social Perception, Cloning, Molecular, Genetic Techniques, Genetic Engineering, Biotechnology
- Abstract
The ability to identify the designer of engineered biological sequences-termed genetic engineering attribution (GEA)-would help ensure due credit for biotechnological innovation, while holding designers accountable to the communities they affect. Here, we present the results of the first Genetic Engineering Attribution Challenge, a public data-science competition to advance GEA techniques. Top-scoring teams dramatically outperformed previous models at identifying the true lab-of-origin of engineered plasmid sequences, including an increase in top-1 and top-10 accuracy of 10 percentage points. A simple ensemble of prizewinning models further increased performance. New metrics, designed to assess a model's ability to confidently exclude candidate labs, also showed major improvements, especially for the ensemble. Most winning teams adopted CNN-based machine-learning approaches; however, one team achieved very high accuracy with an extremely fast neural-network-free approach. Future work, including future competitions, should further explore a wide diversity of approaches for bringing GEA technology into practical use., (© 2022. The Author(s).)
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- 2022
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12. A How-To Guide for Open-Science Practices in Special Education Research.
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Cook BG, Fleming JI, Hart SA, Lane KL, Therrien WJ, van Dijk W, and Wilson SE
- Abstract
Open-science reforms, which aim to increase credibility and access of research, have the potential to benefit the research base in special education, as well as practice and policy informed by that research base. Awareness of open science is increasing among special education researchers. However, relatively few researchers in the field have experience using multiple open-science practices, and few practical guidelines or resources have been tailored to special education researchers to support their exploration and adoption of open science. In this paper, we described and provided guidelines and resources for applying five core open-science practices-preregistration, registered reports, data sharing, materials sharing, and open-access publishing-in special education research.
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- 2022
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13. Dimensional variability characterization of additively manufactured lattice coupons.
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Snodderly KL, Fogarasi M, Badhe Y, Parikh A, Porter D, Burchi A, Gilmour L, and Di Prima M
- Abstract
Background: Additive manufacturing (AM), commonly called 3D Printing (3DP), for medical devices is growing in popularity due to the technology's ability to create complex geometries and patient-matched products. However, due to the process variabilities which can exist between 3DP systems, manufacturer workflows, and digital conversions, there may be variabilities among 3DP parts or between design files and final manufactured products. The overall goal of this project is to determine the dimensional variability of commercially obtained 3DP titanium lattice-containing test coupons and compare it to the original design files., Methods: This manuscript outlines the procedure used to measure dimensional variability of 3D Printed lattice coupons and analyze the differences in external dimensions and pore area when using laser and electron beam fabricated samples. The key dimensions measured were the bulk length, width, and depth using calipers. Strut thickness and pore area were assessed for the lattice components using optical imaging and µCT., Results: Results show a difference in dimensional measurement between printed parts and the computer-designed files for all groups analyzed including the internal lattice dimensions. Measurements of laser manufactured coupons varied from the nominal by less than 0.2 mm and results show averages greater than the nominal value for length, width, and depth dimensions. Measurements of Electron Beam Melting coupons varied between 0.4 mm-0.7 mm from the nominal value and showed average lengths below the nominal dimension while the width and depths were greater than the nominal values. The length dimensions of Laser Powder Bed Fusion samples appeared to be impacted by hot isostatic press more than the width and depth dimension. When lattice relative density was varied, there appeared to be little impact on the external dimensional variability for the as-printed state., Conclusions: Based on these results, we can conclude that there are relevant variations between designed files and printed parts. However, we cannot currently state if these results are clinically relevant and further testing needs to be conducted to apply these results to real-world situations., (© 2022. The Author(s).)
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- 2022
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14. Exploring Views and Professional Learning Needs of Comprehensive, Integrated, Three-Tiered (Ci3T) Leadership Teams Related to Universal Behavior Screening Implementation.
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Briesch AM, Lane KL, Common EA, Oakes WP, Buckman MM, Chafouleas SM, Iovino EA, Sherod RL, Abdulkerim N, and Royer DJ
- Abstract
Research conducted to date has highlighted barriers to initial adoption of universal behavior screening in schools. However, little is known regarding the experiences of those implementing these procedures and there have been no studies conducted examining the experiences of educators in different stages of implementing various tiered systems of supports. Universal screening is foundational to a successful Comprehensive, Integrated Three-Tiered (Ci3T) model of prevention-an integrated tiered system addressing academics, behavior, and social and emotional well-being. Therefore, the perspectives of Ci3T Leadership Team members at different stages of Ci3T implementation were solicited through an online survey that sought to understand (1) current school-based screening practices and (2) individual beliefs regarding those practices. A total of 165 Ci3T Leadership Team members representing five school districts from three geographic regions across the United States, all of whom were participating in an Institute of Education Sciences Network grant examining integrated tiered systems, reported the screening procedures were generally well-understood and feasible to implement. At the same time, results highlighted continuing professional learning may be beneficial in the areas of: (1) integrating multiple sources of data (e.g., screening data with other data collected as regular school practices) and (2) using those multiple data sources to determine next steps for intervention. We discuss educational implications, limitations, and directions for future inquiry., Competing Interests: Conflicts of InterestsOn behalf of all authors, the corresponding author states that there is no conflict of interest., (© Association for Behavior Analysis International 2022.)
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- 2022
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15. Venezuelan Equine Encephalitis Virus V3526 Vaccine RNA-Dependent RNA Polymerase Mutants Increase Vaccine Safety Through Restricted Tissue Tropism in a Murine Model.
- Author
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Haines CA, Campos RK, Azar SR, Warmbrod KL, Kautz TF, Forrester NL, and Rossi SL
- Abstract
Background: Venezuelan equine encephalitis virus (VEEV) is an arbovirus endemic to the Americas. There are no approved vaccines or antivirals. TC-83 and V3526 are the best-characterized vaccine candidates for VEEV. Both are live-attenuated vaccines and have been associated with safety concerns, albeit less so for V3526. A previous attempt to improve the TC-83 vaccine focused on further attenuating the vaccine by adding mutations that altered the error incorporation rate of the RNA-dependent RNA polymerase (RdRp)., Methods: The research presented here examines the impact of these RdRp mutations in V3526 by cloning the 3X and 4X strains, assessing vaccine efficacy against challenge in adult female CD-1 mice, examining neutralizing antibody titers, investigating vaccine tissue tropism, and testing the stability of the mutant strains., Results: Our results show that the V3526 RdRp mutants exhibited reduced tissue tropism in the spleen and kidney compared to wild-type V3526, while maintaining vaccine efficacy. Illumina sequencing showed that the RdRp mutations could revert to wild-type V3526., Conclusions: The observed genotypic reversion is likely of limited concern because wild-type V3526 is still an effective vaccine capable of providing protection. Our results indicate that the V3526 RdRp mutants may be a safer vaccine design than the original V3526., Competing Interests: Conflicts of Interest The authors have no Conflicts of Interest to declare.
- Published
- 2022
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16. The Need for a Tiered Registry for US Gene Drive Governance.
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Warmbrod KL, Kobokovich AL, West R, Gronvall GK, and Montague M
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- Humans, Registries, Gene Drive Technology
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- 2022
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17. A Closing Window of Opportunity for Gene Drive Governance in the United States.
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Warmbrod KL, Montague M, and Gronvall GK
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- Health Policy, Humans, United States, Gene Drive Technology
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- 2022
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18. Using prediction polling to harness collective intelligence for disease forecasting.
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Sell TK, Warmbrod KL, Watson C, Trotochaud M, Martin E, Ravi SJ, Balick M, and Servan-Schreiber E
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- Disease Outbreaks, Forecasting, Humans, Intelligence, Models, Statistical, SARS-CoV-2, COVID-19
- Abstract
Background: The global spread of COVID-19 has shown that reliable forecasting of public health related outcomes is important but lacking., Methods: We report the results of the first large-scale, long-term experiment in crowd-forecasting of infectious-disease outbreaks, where a total of 562 volunteer participants competed over 15 months to make forecasts on 61 questions with a total of 217 possible answers regarding 19 diseases., Results: Consistent with the "wisdom of crowds" phenomenon, we found that crowd forecasts aggregated using best-practice adaptive algorithms are well-calibrated, accurate, timely, and outperform all individual forecasters., Conclusions: Crowd forecasting efforts in public health may be a useful addition to traditional disease surveillance, modeling, and other approaches to evidence-based decision making for infectious disease outbreaks., (© 2021. The Author(s).)
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- 2021
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19. COVID-19 and the gain of function debates: Improving biosafety measures requires a more precise definition of which experiments would raise safety concerns.
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Warmbrod KL, Montague MG, and Gronvall GK
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- Containment of Biohazards, Gain of Function Mutation, Humans, Pandemics, SARS-CoV-2, COVID-19
- Abstract
The COVID-19 pandemic has rekindled debates about gain-of-function experiments. This is an opportunity to clearly define safety risks and appropriate countermeasures., (© 2021 The Authors. Published under the terms of the CC BY 4.0 license.)
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- 2021
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20. Transforming grief into peace: The normal grieving mind-Memory construction, deconstruction, and reconsolidation.
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Rossi KL
- Subjects
- Consciousness, Emotions, Grief, Humans, Hypnosis
- Abstract
On the 19
th of September 2020 Ernest Rossi, my husband, professional partner, and best friend of 30 years left this mortal world. His passing was a comparatively rapid process of dissipation extended over a period of approximately six days. In addition to the complex of emotions and physical responses, I experienced grief. This grief affected me more than any prior loss or sadness in my life as my consciousness was altered into fluctuating quantum trance states characteristic of hypnosis while dancing on the spacetime continuum. As I transformed grief to peace, I utilized established "Rossi" principles as guidelines for effective therapeutic hypnosis and developing a satisfying life. In the tradition of our life together, I was the "operator" who had a subjective experience and yet, at the same time, I was also the "observer" who would watch, learn, and discover new knowledge. This paper is the emergent outpouring of the dynamic interplay between the observer and the operator , which is, therefore experiential, revealing, revelational, and numinous.- Published
- 2021
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21. Electrodynamics of clinical hypnosis.
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Dyba J, Rossi KL, Żurek M, and Rossi EL
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- Humans, Hypnosis
- Abstract
This paper reconstructs and attempts to verify hypotheses made by Leonard Ravitz, Ernest L. Rossi, and Milton H. Erickson, during their research on the influence of hypnosis on the human electromagnetic field. Original charts measured electrodynamic voltage differences of 44 subjects. These voltage differences from Ravitz, Erickson and Rossi's research were digitalized and analyzed with statistical software to check the significance of four hypotheses about ways hypnosis influences the individual's electrodynamic recording. The results of this analysis of the magnitude of the subject's electrodynamic tracing were: (1) there was a statistically significant difference between the prehypnotic condition and hypnosis; (2) there was a statistically significant difference between hypnosis and posthypnotic condition; (3) there was no significant difference between posthypnotic and prehypnotic condition; and (4) there was a statistically significant correlation between an induction of catalepsy and alterations in the electrodynamic tracing. The significance of these findings is discussed with applications to Rossi's 4-Stage Creative Cycle.
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- 2021
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22. A Productive Scholar's Guide to Respectful, Responsible Inquiry During the COVID-19 Pandemic: Moving Forward.
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Lane KL, Cabell SQ, and Drew SV
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- Ethics, Research, Guidelines as Topic, Humans, Research Design standards, COVID-19, Education, Research standards, Research Personnel ethics, Research Personnel standards, Schools
- Abstract
As a result of the COVID-19 pandemic of 2020, schools across the country have pivoted to providing a range of instructional opportunities including remote, hybrid, and modified in-person options with a commitment to keeping our society safe and supporting our nations' youth in continuing their education. One byproduct of this most challenging situation has been the interruption of scientific inquiry in many fields, including educational research. Using a framework of self-leadership, in this feature article, we provide reflections to guide discussion among scholars involved in school-based research during and after the COVID-19 pandemic. Based on lessons learned in our own mentee-mentor relationships and from our collective experiences, the purpose of this article is to offer considerations primarily for early-career scholars, but also to engage dialogue among mid- and late-career scholars to promote school-based inquiry in this defining moment in history, at a time when educators are concerned with mitigating learning loss. We focus on (a) revisiting and refining programmatic lines of inquiry, (b) crafting articles to disseminate lessons learned from research conducted to date-including those with lost time points, (c) retooling in a focused area of inquiry (e.g., methodology), (d) conceptualizing future studies featuring procedures that do-and do not-allow for interpersonal contact, and (e) appreciating and acknowledging individuals who have facilitated inquiry. We conclude with a note of encouragement and call to action for future educational research.
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- 2021
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23. Biosafety Professionals: A Role in the Pandemic Response Team.
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Warmbrod KL, Cole J, Sharkey CM, Sengupta A, Connell N, Casagrande R, and Delarosa P
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- Attitude of Health Personnel, COVID-19 transmission, Humans, COVID-19 epidemiology, COVID-19 prevention & control, Containment of Biohazards trends, Infection Control organization & administration, Laboratories standards
- Published
- 2021
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24. Why Social Distance Demands Social Justice: Systemic Racism, COVID-19, and Health Security in the United States.
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Ravi SJ, Warmbrod KL, Barlow A, Cepeda J, Falade-Nwulia OO, Haroz EE, and Purnell TS
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- Humans, COVID-19, Physical Distancing, Public Health, Racism, Security Measures, Social Justice
- Published
- 2021
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25. A Case of Diabetic Myonecrosis.
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Lane KL, Weinreb A, Chow K, and Weinreb J
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- 2021
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26. Response letter to Simoneau et al.
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Lane KL, Abusamaan MS, and Mathioudakis N
- Abstract
Competing Interests: Declaration of competing interest None.
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- 2021
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27. Project ENHANCE: Assessing Professional Learning Needs for Implementing Comprehensive, Integrated, Three-Tiered (Ci3T) Models of Prevention.
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Common EA, Buckman MM, Lane KL, Oakes WP, Royer DJ, Chafouleas S, Briesch A, and Sherod R
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We report findings from a multistate survey of 720 faculty and staff from 25 elementary schools in five districts across three states and geographic regions participating in an IES Network grant examining integrated tiered systems. In this preregistered study, we replicated and extended previous inquiry examining educators' views of (1) implementation of core components of their school's Comprehensive, Integrated, Three-Tiered (Ci3T) model of prevention; and (2) preference for professional learning (content and avenue). Results indicated more than half of respondents indicated high levels of implementation of core features of Ci3T across Tiers 1, 2, and 3. Educators reported high levels of implementation for 10 out of 19 research-based educational practices used within tiered systems with a statistically significant relation between ratings of implemented practices and the desire for support with most practices. Respondents identified their top three areas for professional development needed in the coming year as behavior deescalation techniques, small-group social skills instruction, and strategies for supporting students with internalizing behavior patterns. For potential professional learning avenues, respondents' top ratings were in-district, during-school workshops, course for college credit on-line, teacher collaboratives/networks, and one-to-one coaching or mentoring. There were many similarities among educators' ratings across implementation year and state. Low levels of implementation across many core Ci3T and common educational practices were reported by educators working within the most experienced schools. We conclude with a discussion of implications, limitations, and future directions., Supplementary Information: The online version contains supplementary material available at 10.1007/s43494-021-00049-z., (© Association for Behavior Analysis International 2021.)
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- 2021
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28. Current State of Mass Vaccination Preparedness and Operational Challenges in the United States, 2018-2019.
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Hosangadi D, Shearer MP, Warmbrod KL, Kan L, Cantu M, and Nuzzo JB
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- Disaster Planning trends, Humans, Mass Vaccination organization & administration, Vaccination, COVID-19, Civil Defense trends, Mass Vaccination trends, Medical Countermeasures, Public Health, Vulnerable Populations ethnology
- Abstract
Mass vaccination is a crucial public health intervention during outbreaks or pandemics for which vaccines are available. The US government has sponsored the development of medical countermeasures, including vaccines, for public health emergencies; however, federally supported programs, including the Public Health and Emergency Preparedness program and Cities Readiness Initiative, have historically emphasized antibiotic pill dispensing over mass vaccination. While mass vaccination and pill dispensing programs share similarities, they also have fundamental differences that require dedicated preparedness efforts to address. To date, only a limited number of public assessments of local mass vaccination operational capabilities have been conducted. To fill this gap, we interviewed 37 public health and preparedness officials representing 33 jurisdictions across the United States. We aimed to characterize their existing mass vaccination operational capacities and identify challenges and lessons learned in order to support the efforts of other jurisdictions to improve mass vaccination preparedness. We found that most jurisdictions were not capable of or had not planned for rapidly vaccinating their populations within a short period of time (eg, 1 to 2 weeks). Many also noted that their focus on pill dispensing was driven largely by federal funding requirements and that preparedness efforts for mass vaccination were often self-motivated. Barriers to implementing rapid mass vaccination operations included insufficient personnel qualified to administer vaccinations, increased patient load compared to pill-dispensing modalities, logistical challenges to maintaining cold chain, and operational challenges addressing high-risk populations, including children, pregnant women, and non-English-speaking populations. Considering the expected availability of a severe acute respiratory syndrome coronavirus 2 vaccine for distribution and dispensing to the public, our findings highlight critical considerations for planning possible future mass vaccination events, including during the novel coronavirus disease 2019 pandemic.
- Published
- 2020
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29. Early Insights from Statistical and Mathematical Modeling of Key Epidemiologic Parameters of COVID-19.
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Biggerstaff M, Cowling BJ, Cucunubá ZM, Dinh L, Ferguson NM, Gao H, Hill V, Imai N, Johansson MA, Kada S, Morgan O, Pastore Y Piontti A, Polonsky JA, Prasad PV, Quandelacy TM, Rambaut A, Tappero JW, Vandemaele KA, Vespignani A, Warmbrod KL, and Wong JY
- Subjects
- COVID-19, Coronavirus Infections transmission, Humans, Pandemics, Pneumonia, Viral transmission, SARS-CoV-2, Betacoronavirus, Coronavirus Infections epidemiology, Disease Transmission, Infectious statistics & numerical data, Models, Statistical, Models, Theoretical, Pneumonia, Viral epidemiology
- Abstract
We report key epidemiologic parameter estimates for coronavirus disease identified in peer-reviewed publications, preprint articles, and online reports. Range estimates for incubation period were 1.8-6.9 days, serial interval 4.0-7.5 days, and doubling time 2.3-7.4 days. The effective reproductive number varied widely, with reductions attributable to interventions. Case burden and infection fatality ratios increased with patient age. Implementation of combined interventions could reduce cases and delay epidemic peak up to 1 month. These parameters for transmission, disease severity, and intervention effectiveness are critical for guiding policy decisions. Estimates will likely change as new information becomes available.
- Published
- 2020
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30. Glycemic control and diabetic foot ulcer outcomes: A systematic review and meta-analysis of observational studies.
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Lane KL, Abusamaan MS, Voss BF, Thurber EG, Al-Hajri N, Gopakumar S, Le JT, Gill S, Blanck J, Prichett L, Hicks CW, Sherman RL, Abularrage CJ, and Mathioudakis NN
- Subjects
- Humans, Observational Studies as Topic, Diabetic Foot therapy, Glycemic Control
- Abstract
Objective: To evaluate the association between glycemic control (hemoglobin A1C, fasting glucose, and random glucose) and the outcomes of wound healing and lower extremity amputation (LEA) among patients with diabetic foot ulcers (DFUs)., Research Design and Methods: Medline, EMBASE, Cochrane Library, and Scopus were searched for observational studies published up to March 2019. Five independent reviewers assessed in duplicate the eligibility of each study based on predefined eligibility criteria and two independent reviewers assessed risk of bias. Ameta-analysis was performed to calculate a pooled odds ratio (OR) or hazard ratio (HR) using random effects for glycemic measures in relation to the outcomes of wound healing and LEA. Subgroup analyses were conducted to explore potential source of heterogeneity between studies. The study protocol is registered with PROSPERO (CRD42018096842)., Results: Of 4572 study records screened, 60 observational studies met the study eligibility criteria of which 47 studies had appropriate data for inclusion in one or more meta-analyses(n = 12,604 DFUs). For cohort studies comparing A1C >7.0 to 7.5% vs. lower A1C levels, the pooled OR for LEA was 2.04 (95% CI, 0.91, 4.57) and for studies comparing A1C ≥ 8% vs. <8%, the pooled OR for LEA was 4.80 (95% CI 2.83, 8.13). For cohort studies comparing fasting glucose ≥126 vs. <126 mg/dl, the pooled OR for LEA was 1.46 (95% CI, 1.02, 2.09). There was no association with A1C category and wound healing (OR or HR). There was high risk of bias with respect to comparability of cohorts as many studies did not adjust for potential confounders in the association between glycemic control and DFU outcomes., Conclusions: Our findings suggest that A1C levels ≥8% and fasting glucose levels ≥126 mg/dl are associated with increased likelihood of LEA in patients with DFUs. A purposively designed prospective study is needed to better understand the mechanisms underlying the association between hyperglycemia and LEA., Competing Interests: Declaration of competing interest No potential conflicts of interest relevant to this study were reported. This work was prepared when J.L. was a methodologist at the Johns Hopkins Bloomberg School of Public Health. The opinions expressed in this article are the author's own and do not reflect the view of the National Institutes of Health, the Department of Health and Human Services, or the United States government., (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Published
- 2020
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31. The value proposition of the Global Health Security Index.
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Ravi SJ, Warmbrod KL, Mullen L, Meyer D, Cameron E, Bell J, Bapat P, Paterra M, Machalaba C, Nath I, Gostin LO, James W, George D, Nikkari S, Gozzer E, Tomori O, Makumbi I, and Nuzzo JB
- Subjects
- Benchmarking organization & administration, Betacoronavirus, COVID-19, Coronavirus Infections epidemiology, Coronavirus Infections mortality, Coronavirus Infections prevention & control, Humans, Leadership, Pandemics prevention & control, Pneumonia, Viral epidemiology, Pneumonia, Viral mortality, Pneumonia, Viral prevention & control, SARS-CoV-2, Global Health, Security Measures organization & administration
- Abstract
Infectious disease outbreaks pose major threats to human health and security. Countries with robust capacities for preventing, detecting and responding to outbreaks can avert many of the social, political, economic and health system costs of such crises. The Global Health Security Index (GHS Index)-the first comprehensive assessment and benchmarking of health security and related capabilities across 195 countries-recently found that no country is sufficiently prepared for epidemics or pandemics. The GHS Index can help health security stakeholders identify areas of weakness, as well as opportunities to collaborate across sectors, collectively strengthen health systems and achieve shared public health goals. Some scholars have recently offered constructive critiques of the GHS Index's approach to scoring and ranking countries; its weighting of select indicators; its emphasis on transparency; its focus on biosecurity and biosafety capacities; and divergence between select country scores and corresponding COVID-19-associated caseloads, morbidity, and mortality. Here, we (1) describe the practical value of the GHS Index; (2) present potential use cases to help policymakers and practitioners maximise the utility of the tool; (3) discuss the importance of scoring and ranking; (4) describe the robust methodology underpinning country scores and ranks; (5) highlight the GHS Index's emphasis on transparency and (6) articulate caveats for users wishing to use GHS Index data in health security research, policymaking and practice., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2020
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32. Improving Educators' Knowledge, Confidence, and Usefulness of a Comprehensive, Integrated, Three-tiered (Ci3T) Model of Prevention: Outcomes of Professional Learning.
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Lane KL, Oakes WP, Allen GE, Lane NA, Jenkins AB, Lane KS, Messenger ML, Buckman MM, Fleming KK, and Romine RES
- Abstract
We examined shifts in educators' perceived knowledge, confidence, and usefulness and actual knowledge of concepts in the Comprehensive, Integrated, Three-tiered (Ci3T) model of prevention before and after participation in a practice-based professional learning series to design, implement, and evaluate a Ci3T model for their school. Participants completed the Knowledge, Confidence, and Use (KCU) survey prior to and at the conclusion of the year-long, six-part Ci3T Professional Learning Series. Results indicated participants demonstrated statistically significant increases in perceived and actual knowledge, perceived confidence, and perceived usefulness of concepts measured, with effect sizes suggesting large effects. Implications for supporting educators in designing a Ci3T model of prevention to meet students' educational needs using a practice-based professional learning series are discussed along with limitations and considerations for future research., Competing Interests: Conflicts of interest/ Competing interests: We have no known conflicts of interest to disclose.
- Published
- 2020
33. iGEM and the Biotechnology Workforce of the Future.
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Warmbrod KL, Trotochaud M, and Gronvall GK
- Subjects
- Humans, Students, United States, Workforce trends, Biotechnology education, Genetic Engineering, Synthetic Biology education
- Abstract
An important factor in growing the US bioeconomy is recruiting and training its future workforce. Other science, technology, engineering, and math (STEM) fields have relied on diverse educational opportunities for recruitment, including prestigious high school and collegiate competitions. For genetic engineering and synthetic biology, there are very few competitions; they include the Biodesign Competition and the much larger and scientifically focused International Genetically Engineered Machine (iGEM) competition. iGEM, run by an independent nonprofit organization, is often cited as a measure of progress in developing the synthetic biology workforce. Starting in 2021, iGEM will move its main competitive event, the "Giant Jamboree," from its long-standing home in Boston to Paris, which is likely to negatively affect participation by the US team. In this article, we describe the value of iGEM to the bioeconomy and its upcoming challenges through a review of available literature, observation of the iGEM Jamboree, and interviews with 10 US-based iGEM team coaches. The coaches expressed positive views about the iGEM process for their students in providing a hands-on biotechnology experience, but they were concerned about the funding US students received to participate in iGEM compared with teams from other countries. They were also concerned that the relocation to Paris would negatively affect or preclude their participation. Possible options to continue the benefits of experiential learning in synthetic biology are discussed, including alternative funding for iGEM teams through a grant process and the need for additional biology competitions.
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- 2020
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34. Shaping the US Bioeconomy for Future Economic Development and Sustainability.
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Warmbrod KL, Trotochaud M, and Gronvall GK
- Subjects
- Biotechnology trends, United States, Biotechnology economics, Economic Development, Sustainable Development trends
- Published
- 2020
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35. Enabling emergency mass vaccination: Innovations in manufacturing and administration during a pandemic.
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Hosangadi D, Warmbrod KL, Martin EK, Adalja A, Cicero A, Inglesby T, Watson C, Watson M, and Connell N
- Subjects
- COVID-19, Coronavirus Infections epidemiology, Humans, Manufacturing and Industrial Facilities standards, Mass Vaccination standards, Pneumonia, Viral epidemiology, Viral Vaccines standards, Coronavirus Infections prevention & control, Manufacturing and Industrial Facilities trends, Mass Vaccination organization & administration, Pandemics prevention & control, Pneumonia, Viral prevention & control, Viral Vaccines administration & dosage, Viral Vaccines supply & distribution
- Abstract
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
- Published
- 2020
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36. AUTOIMMUNE DIABETES IN A PATIENT WITH HUMAN IMMUNODEFICIENCY VIRUS ON ANTI-RETROVIRAL THERAPY WITH LITERATURE REVIEW.
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Lane KL and Moin T
- Abstract
Objective: Diabetes that develops in human immunodeficiency virus-infected individuals is typically classified as type 2 diabetes mellitus. Although less commonly reported, it has been shown that autoimmune diabetes can also develop in this population., Methods: We present a case of a patient found to have autoimmune diabetes following initiation of anti-retroviral therapy., Results: A 68-year-old, African American man with human immunodeficiency virus had a nadir CD4 count of 2 cells/μL, which improved with anti-retroviral therapy. He was subsequently diagnosed with type 2 diabetes mellitus but developed worsening glycemic control. Further investigation demonstrated an elevated glutamic acid decarboxylase antibody level >250 IU/mL and a declining C peptide level from 1.82 ng/mL to 0.56 ng/mL. He was ultimately diagnosed with autoimmune diabetes that was treated with insulin glargine and insulin aspart with improvement in his glycemic control., Conclusion: Autoimmune diabetes in this case was attributed to immune reconstitution after anti-retroviral therapy led to recovery from a significantly low CD4 count. While this phenomenon has been described in previous case reports, our case was unique in that autoimmune diabetes affected an older African American man, a different demographic than previously reported. Although the true mechanism of this association remains unknown, the recognition of autoimmune diabetes is crucial as it greatly impacts diabetes management., Competing Interests: DISCLOSURE The authors have no multiplicity of interest to disclose., (Copyright © 2020 AACE.)
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- 2020
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37. Viral RNA-dependent RNA polymerase mutants display an altered mutation spectrum resulting in attenuation in both mosquito and vertebrate hosts.
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Warmbrod KL, Patterson EI, Kautz TF, Stanton A, Rockx-Brouwer D, Kalveram BK, Khanipov K, Thangamani S, Fofanov Y, and Forrester NL
- Subjects
- Animals, Culicidae genetics, Encephalitis Virus, Venezuelan Equine physiology, Phenotype, RNA, Viral genetics, RNA-Dependent RNA Polymerase metabolism, Vertebrates genetics, Culicidae virology, Encephalitis Virus, Venezuelan Equine genetics, Encephalomyelitis, Venezuelan Equine virology, Mutation, RNA-Dependent RNA Polymerase genetics, Vertebrates virology, Virus Replication genetics
- Abstract
The presence of bottlenecks in the transmission cycle of many RNA viruses leads to a severe reduction of number of virus particles and this occurs multiple times throughout the viral transmission cycle. Viral replication is then necessary for regeneration of a diverse mutant swarm. It is now understood that any perturbation of the mutation frequency either by increasing or decreasing the accumulation of mutations in an RNA virus results in attenuation of the virus. To determine if altering the rate at which a virus accumulates mutations decreases the probability of a successful virus infection due to issues traversing host bottlenecks, a series of mutations in the RNA-dependent RNA polymerase of Venezuelan equine encephalitis virus (VEEV), strain 68U201, were tested for mutation rate changes. All RdRp mutants were attenuated in both the mosquito and vertebrate hosts, while showing no attenuation during in vitro infections. The rescued viruses containing these mutations showed some evidence of change in fidelity, but the phenotype was not sustained following passaging. However, these mutants did exhibit changes in the frequency of specific types of mutations. Using a model of mutation production, these changes were shown to decrease the number of stop codons generated during virus replication. This suggests that the observed mutant attenuation in vivo may be due to an increase in the number of unfit genomes, which may be normally selected against by the accumulation of stop codons. Lastly, the ability of these attenuated viruses to transition through a bottleneck in vivo was measured using marked virus clones. The attenuated viruses showed an overall reduction in the number of marked clones for both the mosquito and vertebrate hosts, as well as a reduced ability to overcome the known bottlenecks in the mosquito. This study demonstrates that any perturbation of the optimal mutation frequency whether through changes in fidelity or by alterations in the mutation frequency of specific nucleotides, has significant deleterious effects on the virus, especially in the presence of host bottlenecks., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2019
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38. Use of 5-Aminolevulinic Acid and Daylight Photodynamic Therapy for the Treatment of Actinic Keratoses.
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Shive ML, Coakley BJ, Bierman DF, Serowka Lane KL, Wiegell SR, Haedersdal M, and Zachary CB
- Subjects
- Aminolevulinic Acid administration & dosage, Humans, Sunlight, Treatment Outcome, Aminolevulinic Acid analogs & derivatives, Facial Dermatoses drug therapy, Keratosis, Actinic drug therapy, Photochemotherapy methods, Photosensitizing Agents administration & dosage, Scalp Dermatoses drug therapy
- Abstract
Background: Photodynamic therapy (PDT) is an effective modality for the treatment of actinic keratoses (AKs). The use of methyl aminolevulinate with daylight PDT (D-PDT) has quickly gained popularity internationally because of its tolerability and high levels of safety and efficacy. However, there is a paucity of studies on the use of D-PDT with 5-aminolevulinic acid (ALA)., Objective: To study the safety and efficacy of D-PDT in treating AKs on the face and scalp using ALA., Materials and Methods: Thirty patients were recruited for this prospective, uncontrolled study. Patients were treated with topical ALA on either the scalp or face, incubated for 30 minutes, and then sat at home in a shady area for 2 hours. Weather conditions, lux measurements, and AK counts at 3 and 6 months were measured., Results: Daylight PDT led to a median of 75% reduction in AK count at 6 months, with no significant adverse effects. Ninety-six percentage of patients were either moderately or very satisfied with the treatment, and the median peak pain score during treatment was 1. There was no correlation between weather or average lux received during treatment and 6-month outcomes., Conclusion: Daylight PDT with ALA is a safe and effective treatment modality for AKs on the head.
- Published
- 2019
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39. Evidence for the reliability and preliminary validity of the Adult ADHD Self-Report Scale v1.1 (ASRS v1.1) Screener in an adolescent community sample.
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Green JG, DeYoung G, Wogan ME, Wolf EJ, Lane KL, and Adler LA
- Subjects
- Adolescent, Attention Deficit Disorder with Hyperactivity psychology, Child, Female, Humans, Male, Reproducibility of Results, Self Report, Attention Deficit Disorder with Hyperactivity diagnosis, Psychiatric Status Rating Scales
- Abstract
Objectives: There is a need for brief and publicly-available assessments of attention deficit hyperactivity disorder (ADHD) easily administered in large-scale survey efforts monitoring symptoms among adolescents. The ADHD Self-Report Scale v1.1 (ASRS; Kessler et al., 2005) Screener, a six-item measure of ADHD symptoms, is a valid and reliable screening instrument for ADHD among adults. The current study provides initial evidence for the reliability and validity of the ASRS Screener among a community sample of U.S. adolescents., Methods: Middle and high school students in grades 6 through 12 (N = 2,472) completed the ASRS Screener, along with the Strengths and Difficulties Questionnaire (SDQ; Goodman, 2001) and several questions about school functioning., Results: The ASRS Screener demonstrated good internal consistency, with items captured by a single underlying latent variable, which was invariant across subsamples differing by gender. The ASRS Screener scores were associated with the SDQ subscale measuring hyperactivity/inattention (r = 0.58) and significantly less strongly associated with other SDQ subscale scores (r = -0.15-0.41). The ASRS Screener scores were also significantly associated with student-reported school functioning., Conclusion: Findings suggest directions for future research and provide preliminary support for use of the ASRS Screener as a brief tool for identifying symptoms of ADHD among adolescents., (© 2018 John Wiley & Sons, Ltd.)
- Published
- 2019
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40. Role of the pharmacist in refugee health.
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Carter KL and Bonanni S
- Subjects
- Contraception, Female, Humans, Medication Errors prevention & control, Patient Care Team organization & administration, Patient Medication Knowledge organization & administration, United States, Health Promotion organization & administration, Health Services Accessibility organization & administration, Pharmacists organization & administration, Professional Role, Refugees
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- 2019
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41. Factor analytic replication and model comparison of the BASC-2 Behavioral and Emotional Screening System.
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Splett JW, Raborn A, Lane KL, Binney AJ, and Chafouleas SM
- Subjects
- Adolescent, Child, Factor Analysis, Statistical, Female, Humans, Male, Observer Variation, Reproducibility of Results, Southeastern United States, Students psychology, Affective Symptoms diagnosis, Affective Symptoms psychology, Child Behavior Disorders diagnosis, Child Behavior Disorders psychology, Mass Screening statistics & numerical data, Personality Assessment statistics & numerical data, Psychometrics statistics & numerical data
- Abstract
We conducted this study to add to literature of previous conflicting factorial examinations of the BASC-2 Behavioral and Emotional Screening System (BESS), Teacher Form-Child/Adolescent. Data were collected by an urban school district in the southeastern United States including 2,228 students rated by 120 teachers in Fall 2014 and 1,955 students rated by 104 teachers in Spring 2015. In both samples, we replicated and then conceptually and statistically compared factor models to examine the (a) 4-factor structure from which the BESS Teacher Form was developed, and (b) existence of a general factor currently being used. Previous studies examined the 4-factor and bifactor structure of the BESS Teacher Form on separate samples. Our model comparison results support a multidimensional interpretation. We recovered similar fit statistics and standardized factor loadings as previous factor analyses. However, measures of variance accounted for by the general factor were below recommended thresholds of a unidimensional construct. We recommend advancing a factorial model that represents a weighted combination of general and specific factors, but do not support continued use of a unidimensional total T score. Limitations and implications of the study are discussed. (PsycINFO Database Record, ((c) 2017 APA, all rights reserved).)
- Published
- 2017
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42. Building Strong Partnerships: Education and Mental Health Systems Working Together to Advance Behavioral Health Screening in Schools.
- Author
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Lane KL, Oakes WP, Crocker J, and Weist MD
- Abstract
In this article, we have introduced a key challenge confronting the fields of education and mental health: the need for early detection of EBDs among students and a framework for early response to their needs. Next, we offered a potential solution: prioritizing strong, integrated partnerships between education and mental health systems. Following this discussion, we provided two illustrations (1) teacher-completed behavior screening within a Ci3T model of prevention in an elementary school setting and (2) student self-reported mental health screening in the high school setting. The differences in the screening measures used in the two illustrations are important. The first illustrates universal behavior screening conducted as part of regular school practices to inform instruction. Teacher-completed screeners are based on observed student behaviors, with screening as a way to measure and monitor teachers' observations. The second illustrates the use of mental health screening (student self-report). Additional protections for self-report measures must be afforded, such as parent/guardian permission and opt-out options as discussed in the high school illustration. Finally, we have offered a call to action, posing considerations for next steps for researchers, practitioners, and policymakers. We hope this concluding article in the four-issue 2017 volume of the Report on Emotional & Behavioral Disorders in Youth will help to propel improvements in research, practice, and policy of the foundational issue of early identification of students in need of successful school behavioral health programs.
- Published
- 2017
43. The computation of confidence intervals for the state parameters of power systems.
- Author
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Khan Z, Razali RB, Daud H, Nor NM, Fotuhi-Firuzabad M, and Krebs KL
- Abstract
Background: In the past few decades, a significant volume of work has been carried out on various aspects of the state estimation problem to estimate an optimum state vector of the power system. This problem has been focused on, in previous studies regarding the computational efficiency and numerical robustness in view to find point estimates for system state parameters. This current investigation, constructed confidence intervals for the unknown state parameters of the system. The research indicates that confidence intervals can yield addition useful information about the estimated parameters., Methods: The feasible interval estimates for the system state parameters have been modelled in this study by considering the random uncertainty in the processing measurements. The statistical assumptions of the measurement errors have been utilized to characterize the probabilistic behavior of the estimated parameters in terms of confidence intervals. The Gauss-Newton algorithm has been adopted for maximizing the likelihood function of the processing measurements and obtaining the confidence intervals., Results: The usage of the confidence intervals was demonstrated through Monte Carlo experiments on a real dataset of the 6-bus and IEEE 14-bus power systems for both small and large sample sizes. The confidence intervals were constructed for the test networks for the sample of measurements 18, 28, 44 and 68 based on the redundancy ratio R. The proposed interval estimates outperformed for the sample sizes of 28 in the 6 bus and 68 in the IEEE 14-bus systems, respectively. The poor performance for the constructed interval estimates have been reported even for the large sample sizes in the existence of contaminated measurements., Conclusions: The results of the study show that the method is effective and practically applicable in the state estimation of a power system. The constructed confidence intervals for the system state parameters adequately perform for the lager sample size. However, the existence of the gross errors in the processing measurements had severe effect on the performance of the proposed interval estimates.
- Published
- 2016
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44. Advanced Reading Comprehension Expectations in Secondary School: Considerations for Students with Emotional or Behavior Disorders.
- Author
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Ciullo S, Ortiz MB, Al Otaiba S, and Lane KL
- Abstract
The debate around recent implementation of the Common Core Standards (CCSS) has perplexed many policy makers, practitioners, and researchers; yet there remains broad agreement for the need to improve reading outcomes and college and career readiness for all students, including students with disabilities. One of the most vulnerable populations with disabilities in terms of college and career readiness is students with emotional disorders (ED). A considerable percentage of students with ED encounter unfavorable academic and long-term outcomes, often due to reading difficulties and behavioral variables that impede learning. To date, the impact of rising expectations in reading on the education of students with ED has been absent from this conversation about CCSS. In this article, we consider the implications of new reading expectations in the critical period of Grades 6-12 for students with ED. First, we summarize grade level expectations of the standards. Then, we describe the characteristics and underachievement of students with ED. Next, we evaluate challenges in meeting the expectations based on extant research, and provide recommendations for practice based on the intervention literature. We conclude by prioritizing a research and policy agenda that advocates for increasing the likelihood of success in reading for students with ED in middle school and high school.
- Published
- 2016
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45. Review of antibiotic use in respiratory disorders at a regional hospital in Queensland.
- Author
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McGoldrick C, Ulahannan T, and Krebs KL
- Abstract
tAdherence to antibiotic guidelines has been shown to improve outcomes in several clinical situations.Respiratory conditions are a major cause of mortality and morbidity in Queensland. A recent study showedlow levels of compliance with antibiotic guidelines in a Queensland metropolitan hospital. We undertookan audit of antibiotic use in a regional Queensland hospital against Therapeutic Guideline recommenda-tions. Therapeutic Guideline recommendations were followed in 16% of cases with ceftriaxone the mostcommonly prescribed. Re-admission rate within 28 days was for 53%, 26%, 11% and 5% respectively forceftriaxone, benzylpenicillin, amoxicillin/clavulanate and ceftriaxone combined doxycycline. Less thanhalf of patients treated for pneumonia had concordant radiographic changes. Admission via the emer-gency department may be a factor in the preference for intravenous injection of ceftriaxone and presenceof non-infective co-morbidities may also contribute to re-admissions. Considerable challenges exist inimproving compliance with antibiotic guidelines which can improve patient outcomes and antibioticstewardship.
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- 2016
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46. Daylight photodynamic therapy: the Southern California experience.
- Author
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Lane KL, Hovenic W, Ball K, and Zachary CB
- Subjects
- Aged, Aged, 80 and over, Cohort Studies, Female, Humans, Keratosis, Actinic pathology, Male, Middle Aged, Treatment Outcome, Aminolevulinic Acid therapeutic use, Keratosis, Actinic drug therapy, Photochemotherapy methods, Photosensitizing Agents therapeutic use, Sunlight
- Abstract
Background: Photodynamic therapy (PDT) is a safe and effective treatment for actinic keratoses (AKs) and photoactinic damage. Three elements are needed for PDT: a photosensitizer, oxygen, and a light source. Conventional PDT is performed with a variety of different laser and light sources including blue, yellow and red in addition to filtered intense pulsed lights (IPL). Daylight PDT, using ambient visible light has been reported as safe, time- and cost-efficient, and more comfortable than with other light sources. We report our experience with daylight PDT in 80 patients., Material and Methods: Eighty patients with multiple actinic keratoses related to chronic photodamage underwent one or two sessions with daylight PDT. Anatomic locations treated included face, chest, arms, and legs. Aminolevulinic acid (ALA, Levulan, Kerastick Dusa USA) was applied one hour prior to light exposure. Thick actinic keratoses were gently curetted prior to ALA application. A chemical sunscreen was applied thirty minutes into the incubation and subsequently patients sat outside in the shade for 2.5 hours. The following day, patients applied a chemical sunscreen and went into either shaded or direct sunlight for 15-30 extra minutes depending on sensitivity. Significant pain associated with this second day exposure was an indication to return indoors immediately. After the second exposure they were instructed to stay inside for the remainder of the 48 hour post treatment period., Results: All patients tolerated the procedure well. Patients denied any pain during the first two and half hour exposure. The second day exposure elicited a mild burning sensation that patients rated as a 2-3/10 though some patients elected to go outside protocol and 'tough it out' despite more significant discomfort. Patients and physicians noted significant reduction in photoactinic damage and actinic keratoses. Patients appreciated the convenience of the treatment. There were no significant adverse events, and no patients reported scarring., Conclusion: In this case series, daylight PDT achieved obvious improvement in photodamage, specifically precancerous lesions, and in photoaging with a reduction in lentigenes and other signs of aging. Patients reported significantly less pain than with conventional PDT and enjoyed the convenience of treatment generally in their backyard. It was noted to be a safe procedure with no significant adverse events such as scarring. Additionally, the cost of the procedure was significantly reduced, with ALA and its application being the only expenses., (© 2015 Wiley Periodicals, Inc.)
- Published
- 2015
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47. Little people, big lessons: an innovative strategy to develop interpersonal skills in undergraduate nursing students.
- Author
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Reid Searl K, McAllister M, Dwyer T, Krebs KL, Anderson C, Quinney L, and McLellan S
- Subjects
- Child, Female, Focus Groups, Humans, Learning, Male, Models, Educational, Patient Simulation, Play and Playthings, Social Skills, Empathy, Nurse-Patient Relations, Pediatric Nursing education, Students, Nursing psychology
- Abstract
Learning the skills of child health nursing requires more than technical skill development. Humanistic attributes such as being genuine, accepting and empathic are imperative in gaining the trust of a child and in helping them feel comforted and safe in a health care setting. Interpersonal theory has a long history in nursing and numerous contemporary theories have drawn on the seminal work of Peplau to advance nursing practice. However, rarely has this theory been applied to simulation learning. This paper reports on an innovative simulation technique that blends interpersonal theory with puppets. Qualitative evaluation using focus group method with fifteen undergraduate nursing students revealed that the pedagogy had a positive impact on characteristics of the learner, the learning process and on interpersonal communication skills development. The study deepened insights about the educative process and led to learning impacts that suggest that puppet-based learning is a powerful medium to bridge theory and practice, bringing the importance of interpersonal theory to life for students., (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
48. Understanding and preventing violence directed against teachers: recommendations for a national research, practice, and policy agenda.
- Author
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Espelage D, Anderman EM, Brown VE, Jones A, Lane KL, McMahon SD, Reddy LA, and Reynolds CR
- Subjects
- Humans, Students psychology, Violence legislation & jurisprudence, Violence psychology, Violence statistics & numerical data, Faculty statistics & numerical data, Students statistics & numerical data, Violence prevention & control
- Abstract
Violence directed against K-12 teachers is a serious problem that demands the immediate attention of researchers, providers of teacher pre-service and in-service training, school administrators, community leaders, and policymakers. Surprisingly, little research has been conducted on this growing problem despite the broad impact teacher victimization can have on schooling, recruitment, and retention of highly effective teachers and on student academic and behavioral outcomes. Psychologists should play a leadership role in mitigating school violence, including violence directed toward teachers. There is a need for psychologists to conduct research accurately assessing the types and scope of violence that teachers experience; to comprehensively evaluate the individual, classroom, school, community, institutional, and cultural contextual factors that might predict and/or explain types of teacher violence; and to examine the effectiveness and sustainability of classroom, school, and district-wide prevention and intervention strategies that target teacher violence in school systems. Collectively, the work of psychologists in this area could have a substantial impact on schooling, teacher experience and retention, and overall student performance., ((c) 2013 APA, all rights reserved.)
- Published
- 2013
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49. Application of dissolution/permeation system for evaluation of formulation effect on oral absorption of poorly water-soluble drugs in drug development.
- Author
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Kataoka M, Sugano K, da Costa Mathews C, Wong JW, Jones KL, Masaoka Y, Sakuma S, and Yamashita S
- Subjects
- Administration, Oral, Animals, Caco-2 Cells, Chemistry, Pharmaceutical, Chromones blood, Chromones chemistry, Danazol blood, Danazol chemistry, Drug Compounding, Humans, Male, Permeability, Rats, Rats, Wistar, Solubility, Technology, Pharmaceutical methods, Chromones administration & dosage, Chromones pharmacokinetics, Danazol administration & dosage, Danazol pharmacokinetics, Intestinal Absorption, Intestinal Mucosa metabolism
- Abstract
Purpose: The aim of the present study is to evaluate the formulation effect on the oral absorption of poorly water-soluble drugs using a dissolution/permeation system (D/P system)., Methods: This D/P system, consisting of apical and basal chambers and a Caco-2 cell monolayer mounted between chambers, can be used to perform simultaneous analysis of drug dissolution and permeation process of drugs applied as various dosage forms. Oral administration study with rats was also performed for both drugs as the same dosage forms., Results: When danazol, a low-soluble and high-permeable drug, was applied to the D/P system as various formulations, dissolved and permeated amounts were significantly high compared with those from a suspension form. On the other hand, whereas the dissolved amount of pranlukast, a low-soluble and low-permeable drug, was significantly increased by formulations, there were no significant changes observed in the permeated amount between suspension and formulation. The oral availability of danazol was significantly increased by formulations but not pranlukast, which corresponded well to in vitro evaluations., Conclusion: These results indicated that the D/P system might be applicable for selection of formulation on the basis of physicochemical drug properties.
- Published
- 2012
- Full Text
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50. A brief protocol for the Creative Psychosocial Genomic Healing Experience: the 4-Stage Creative Process in therapeutic hypnosis and brief psychotherapy.
- Author
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Rossi EL, Cozzolino M, Mortimer J, Atkinson D, and Rossi KL
- Subjects
- Awareness, Combined Modality Therapy, Communication, Gene Expression, Group Processes, Humans, Inservice Training, Knowledge of Results, Psychological, Mental Healing, Mind-Body Relations, Metaphysical, Peer Group, Problem Solving, Psychotherapy, Brief education, Social Support, Suggestion, Creativity, Education, Continuing, Epigenesis, Genetic, Hypnosis methods, Psychotherapy, Brief methods
- Abstract
The authors present empirical data on therapeutic hypnosis and brief psychotherapy as a 4-Stage Creative Process of focused attention and positive expectancy in professional training workshops of the American Society of Clinical Hypnosis, the National Institute for the Clinical Applications of Behavioral Medicine, and the Milton H. Erickson Foundation. The authors developed a brief protocol for assessing the 4-Stage Creative Process, which is the core dynamic of the Creative Psychosocial Genomic Healing Experience. They report that the 4-Stage Creative Process for resolving many psychological problems and symptomatic behavior in a satisfactory manner can be learned within 3 trials during 2-day professional workshops. The theory, research, and practice of private problem solving, stress reduction, and mind-body symptom resolution in professional and public settings is discussed. Immediate knowledge of results, positive peer support, and the development of new psychosocial skills in learning how to appropriately communicate live here-and-now novel and numinous experiences is an exhilarating exercise in creating new consciousness that facilitates the confidence and maturation of psychotherapists.
- Published
- 2011
- Full Text
- View/download PDF
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