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28 results on '"Lane, Whitney O."'

13. The biocompatibility of titanium cardiovascular devices seeded with autologous blood-derived endothelial progenitor cells: EPC-seeded antithrombotic Ti Implants

Author

Achneck, Hardean E., Jamiolkowski, Ryan M., Jantzen, Alexandra E., Haseltine, Justin M., Lane, Whitney O., Huang, Jessica K., Galinat, Lauren J., Serpe, Michael J., Lin, Fu-Hsiung, Li, Madison, Parikh, Amar, Ma, Liqiao, Chen, Tao, Sileshi, Bantayehu, Milano, Carmelo A., Wallace, Charles S., Stabler, Thomas V., Allen, Jason D., Truskey, George A., and Lawson, Jeffrey H.

Published
2011
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14. Extent of tumor fibrosis/hyalinization and infarction following neoadjuvant radiation therapy is associated with improved survival in patients with soft‐tissue sarcoma

Author

Rao, Sneha R., primary, Lazarides, Alexander L., additional, Leckey, Bruce L., additional, Lane, Whitney O., additional, Visgauss, Julia D., additional, Somarelli, Jason A., additional, Kirsch, David G., additional, Larrier, Nicole A., additional, Brigman, Brian E., additional, Blazer, Dan G., additional, Cardona, Diana M., additional, and Eward, William C., additional

Published
2021
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16. Extent of tumor fibrosis/hyalinization and infarction following neoadjuvant radiation therapy is associated with improved survival in patients with soft‐tissue sarcoma.

Author

Rao, Sneha R., Lazarides, Alexander L., Leckey, Bruce L., Lane, Whitney O., Visgauss, Julia D., Somarelli, Jason A., Kirsch, David G., Larrier, Nicole A., Brigman, Brian E., Blazer, Dan G., Cardona, Diana M., and Eward, William C.

Subjects
INFARCTION, NEOADJUVANT chemotherapy, RADIOTHERAPY, OVERALL survival, PROPORTIONAL hazards models, FIBROSIS
Abstract

Introduction: Current standard of care for most intermediate and high‐grade soft‐tissue sarcomas (STS) includes limb‐preserving surgical resection with either neoadjuvant radiation therapy (NRT) or adjuvant radiation therapy. To date, there have been a few studies that attempt to correlate histopathologic response to NRT with oncologic outcomes in patients with STS. Methods: Using our institutional database, we identified 58 patients who received NRT followed by surgical resection for primary intermediate or high‐grade STS and 34 patients who received surgical resection without NRT but did receive adjuvant radiation therapy or did not receive any radiation therapy. We analyzed four histologic parameters of response to therapy: residual viable tumor, fibrosis/hyalinization, necrosis, and infarction (each ratiometrically determined). Data were stratified into two binary groups. Unadjusted, 5‐ and 10‐year overall survival, and relapsed‐free survival (RFS) were calculated using the Kaplan–Meier method. Results: Analysis of pathologic characteristics showed that patients treated with NRT demonstrate significantly higher tumor infarction, higher tumor fibrosis/hyalinization, and a lower percent viable tumor compared with patients not treated with NRT (p < 0.0001). Based on Kaplan–Meier curve analysis and multivariate cox proportional hazard model for OS and RFS, patients treated with NRT and showing >12.5% tumor fibrosis/hyalinization have significantly higher overall survival and recurrence‐free survival at 5 and 10 years. Discussion and Conclusion: We have identified three histopathologic characteristics—fibrosis, hyalinization, and infarction—that may serve as predictive biomarkers of response to NRT for STS patients. Future prospective studies will be needed to confirm this association. [ABSTRACT FROM AUTHOR]

Published
2022
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24. Metastatic ampullary adenocarcinoma presenting as a hydrocele: a case report

Author

Lane, Whitney O, Bentley, Rex C, Hurwitz, Herbert I, Howard, Leigh A, Polascik, Thomas J, Anderson, Mark R, and Blazer, Dan G

Subjects
Diagnosis, Differential, Male, Ampulla of Vater, Testicular Neoplasms, Biopsy, Common Bile Duct Neoplasms, Humans, Adenocarcinoma, Tomography, X-Ray Computed, pancreatic neoplasm, neoplasm metastasis, testicular neoplasm/secondary, testicular hydrocele, pancreaticojejunostomy, Aged, Pancreaticoduodenectomy, Testicular Hydrocele
Abstract

Context Metastases from ampullary malignancies are common, but spread to the testicle and paratesticular tissue is exceedingly rare with only 2 reported cases in the literature. Case Report We report a case of a 70 year-old male with a history of ampullary adenocarcinoma status post pancreaticoduodenectomy who presented with a symptomatic right-sided hydrocele. Subsequent pathology revealed metastatic ampullary adenocarcinoma. Conclusions Metastasis to the testicle and paratesticular tissue from ampullary malignancies is rare, but must be considered in the evaluation of scrotal masses in patients with a history of ampullary malignancy., JOP. Journal of the Pancreas, Vol 15, No 3 (2014): May - p. 219-279

Published
2014

25. The Biocompatibility of Titanium Cardiovascular Devices Seeded With Autologous Blood-Derived Endothelial Progenitor Cells: EPC-Seeded Antithrombotic Ti Implants

Author

Achneck, Hardean E., Jamiolkowski, Ryan M., Jantzen, Alexandra E., Haseltine, Justin, Lane, Whitney O., Huang, Jessica, Galinat, Lauren J., Serpe, Michael J., Lin, Fu-Hsiung, Li, Madison, Parikh, Amar, Ma, Liqiao, Chen, Tao, Sileshi, Bantayehu, Milano, Carmelo A., Wallace, Charles S., Stabler, Thomas V., Allen, Jason D., Truskey, George A., and Lawson, Jeffrey H.

Subjects
Titanium, Cell Survival, Surface Properties, Stem Cells, Sus scrofa, Endothelial Cells, Biocompatible Materials, Cell Separation, Nitric Oxide, Article, Platelet Adhesiveness, Fibrinolytic Agents, Implants, Experimental, Cell Movement, Materials Testing, cardiovascular system, Cell Adhesion, Animals, Cattle, Heart-Assist Devices, Stress, Mechanical, Rheology, Cell Proliferation
Abstract

Implantable and extracorporeal cardiovascular devices are commonly made from titanium (Ti) (e.g. Ti-coated Nitinol stents and mechanical circulatory assist devices). Endothelializing the blood-contacting Ti surfaces of these devices would provide them with an antithrombogenic coating that mimics the native lining of blood vessels and the heart. We evaluated the viability and adherence of peripheral blood-derived porcine endothelial progenitor cells (EPCs), seeded onto thin Ti layers on glass slides under static conditions and after exposure to fluid shear stresses. EPCs attached and grew to confluence on Ti in serum-free medium, without preadsorption of proteins. After attachment to Ti for 15 min, less than 5% of the cells detached at a shear stress of 100 dyne / cm(2). Confluent monolayers of EPCs on smooth Ti surfaces (Rq of 10 nm), exposed to 15 or 100 dyne/cm(2) for 48 h, aligned and elongated in the direction of flow and produced nitric oxide dependent on the level of shear stress. EPC-coated Ti surfaces had dramatically reduced platelet adhesion when compared to uncoated Ti surfaces. These results indicate that peripheral blood-derived EPCs adhere and function normally on Ti surfaces. Therefore EPCs may be used to seed cardiovascular devices prior to implantation to ameliorate platelet activation and thrombus formation.

Published
2010

27. Parallel-plate Flow Chamber and Continuous Flow Circuit to Evaluate Endothelial Progenitor Cells under Laminar Flow Shear Stress

Author

Lane, Whitney O., primary, Jantzen, Alexandra E., primary, Carlon, Tim A., primary, Jamiolkowski, Ryan M., primary, Grenet, Justin E., primary, Ley, Melissa M., primary, Haseltine, Justin M., primary, Galinat, Lauren J., primary, Lin, Fu-Hsiung, primary, Allen, Jason D., primary, Truskey, George A., primary, and Achneck, Hardean E., primary

Published
2012
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