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20 results on '"Lane, S. W."'

2. P1033: A PHASE 2 STUDY OF THE LSD1 INHIBITOR IMG-7289 (BOMEDEMSTAT) FOR THE TREATMENT OF ESSENTIAL THROMBOCYTHEMIA (ET)

Author

Palandri, F., primary, Ross, D. M., additional, Cochrane, T., additional, Tate, C., additional, Lane, S. W., additional, Larsen, S. R., additional, Gerds, A. T., additional, Halpern, A. B., additional, Shortt, J., additional, Rossetti, J. M., additional, Pettit, K. M., additional, Liang, J., additional, Mead, A., additional, Marchetti, M., additional, Vannucchi, A., additional, Wilson, A., additional, Göthert, J. R., additional, Hanna, M., additional, Jones, A., additional, Peppe, J., additional, Natsoulis, G., additional, McClure, T., additional, Hong, W.-J., additional, Stevenson, W. S., additional, Harrison, C. N., additional, Talpaz, M., additional, Vianelli, N., additional, and Rienhoff, H. Y., additional

Published
2022
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7. Differential effects on gene transcription and hematopoietic differentiation correlate with GATA2 mutant disease phenotypes

Author

Chong, C-E, primary, Venugopal, P, additional, Stokes, P H, additional, Lee, Y K, additional, Brautigan, P J, additional, Yeung, D T O, additional, Babic, M, additional, Engler, G A, additional, Lane, S W, additional, Klingler-Hoffmann, M, additional, Matthews, J M, additional, D'Andrea, R J, additional, Brown, A L, additional, Hahn, C N, additional, and Scott, H S, additional

Published
2017
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8. A novel, somatic, transforming mutation in the extracellular domain of Epidermal Growth Factor Receptor identified in myeloproliferative neoplasm

Author

Casolari, D. A., primary, Nguyen, T., additional, Butcher, C. M., additional, Iarossi, D. G., additional, Hahn, C. N., additional, Bray, S. C., additional, Neufing, P., additional, Parker, W. T., additional, Feng, J., additional, Maung, K. Z. Y., additional, Wee, A., additional, Vidovic, L., additional, Kok, C. H., additional, Bardy, P. G., additional, Branford, S., additional, Lewis, I. D., additional, Lane, S. W., additional, Scott, H. S., additional, Ross, D. M., additional, and D’Andrea, R. J., additional

Published
2017
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11. Investigation of mice deficient in matriptase-2, Hfe and transferrin receptor 2 reveals a novel non-hepatic role for Tfr2 in erythropoiesis

Author

Wallace, D. F., Secondes, E. S., Rishi, G., Ostini, L., Mcdonald, C. J., Lane, S. W., Hooper, J. D., Lopez-Otin, C., Subramaniam, V. N., Wallace, D. F., Secondes, E. S., Rishi, G., Ostini, L., Mcdonald, C. J., Lane, S. W., Hooper, J. D., Lopez-Otin, C., and Subramaniam, V. N.

Abstract

The liver expressed proteins matriptase‐2 (MT‐2, encoded by TMPRSS6 ), HFE and Transferrin receptor 2 (TFR2) play important roles in systemic iron homeostasis by regulating the expression of the iron regulatory hormone hepcidin in the liver. Mutations in TMPRSS6 lead to iron refractory iron deficiency anaemia, whereas mutations in HFE and TFR2 lead to hereditary hemochromatosis. We generated mice lacking various combinations of Tmprss6 , Hfe and Tfr2 to further elucidate the potentially competing roles of these proteins in hepcidin regulation, iron homeostasis and erythropoiesis.

Published
2014

13. Structure and RNA recognition in recombinant STNV capsids

Author

Phillips, S. E. V., primary, Lane, S. W., additional, Dennis, C. A., additional, Lane, C. L., additional, Trinh, C. H., additional, Rizkallah, P. J., additional, Bunka, D. H. J., additional, Dykeman, E. C., additional, Ford, R., additional, Barker, A., additional, Twarock, R., additional, and Stockley, P. G., additional

Published
2011
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14. Publisher’s Note: Demonstration of Ignition Radiation Temperatures in Indirect-Drive Inertial Confinement Fusion Hohlraums [Phys. Rev. Lett.106, 085004 (2011)]

Author

Glenzer, S. H., primary, MacGowan, B. J., additional, Meezan, N. B., additional, Adams, P. A., additional, Alfonso, J. B., additional, Alger, E. T., additional, Alherz, Z., additional, Alvarez, L. F., additional, Alvarez, S. S., additional, Amick, P. V., additional, Andersson, K. S., additional, Andrews, S. D., additional, Antonini, G. J., additional, Arnold, P. A., additional, Atkinson, D. P., additional, Auyang, L., additional, Azevedo, S. G., additional, Balaoing, B. N. M., additional, Baltz, J. A., additional, Barbosa, F., additional, Bardsley, G. W., additional, Barker, D. A., additional, Barnes, A. I., additional, Baron, A., additional, Beeler, R. G., additional, Beeman, B. V., additional, Belk, L. R., additional, Bell, J. C., additional, Bell, P. M., additional, Berger, R. L., additional, Bergonia, M. A., additional, Bernardez, L. J., additional, Berzins, L. V., additional, Bettenhausen, R. C., additional, Bhandarkar, S. D., additional, Bishop, C. L., additional, Bond, E. J., additional, Bopp, D. R., additional, Borgman, J. A., additional, Bower, J. R., additional, Bowers, G. A., additional, Bowers, M. W., additional, Boyle, D. T., additional, Bradley, D. K., additional, Bragg, J. L., additional, Braucht, J., additional, Brinkerhoff, D. L., additional, Browning, D. F., additional, Brunton, G. K., additional, Burkhart, S. C., additional, Burns, S. R., additional, Burns, K. E., additional, Burr, B., additional, Burrows, L. M., additional, Butlin, R. K., additional, Cahayag, N. J., additional, Callahan, D. A., additional, Cardinale, P. S., additional, Carey, R. W., additional, Carlson, J. W., additional, Casey, A. D., additional, Castro, C., additional, Celeste, J. R., additional, Chakicherla, A. Y., additional, Chambers, F. W., additional, Chan, C., additional, Chandrasekaran, H., additional, Chang, C., additional, Chapman, R. F., additional, Charron, K., additional, Chen, Y., additional, Christensen, M. J., additional, Churby, A. J., additional, Clancy, T. J., additional, Cline, B. D., additional, Clowdus, L. C., additional, Cocherell, D. G., additional, Coffield, F. E., additional, Cohen, S. J., additional, Costa, R. L., additional, Cox, J. R., additional, Curnow, G. M., additional, Dailey, M. J., additional, Danforth, P. M., additional, Darbee, R., additional, Datte, P. S., additional, Davis, J. A., additional, Deis, G. A., additional, Demaret, R. D., additional, Dewald, E. L., additional, Di Nicola, P., additional, Di Nicola, J. M., additional, Divol, L., additional, Dixit, S., additional, Dobson, D. B., additional, Doppner, T., additional, Driscoll, J. D., additional, Dugorepec, J., additional, Duncan, J. J., additional, DuPuy, P. C., additional, Dzenitis, E. G., additional, Eckart, M. J., additional, Edson, S. L., additional, Edwards, G. J., additional, Edwards, M. J., additional, Edwards, O. D., additional, Edwards, P. W., additional, Ellefson, J. C., additional, Ellerbee, C. H., additional, Erbert, G. V., additional, Estes, C. M., additional, Fabyan, W. J., additional, Fallejo, R. N., additional, Fedorov, M., additional, Felker, B., additional, Fink, J. T., additional, Finney, M. D., additional, Finnie, L. F., additional, Fischer, M. J., additional, Fisher, J. M., additional, Fishler, B. T., additional, Florio, J. W., additional, Foxworthy, C. B., additional, Franks, R. M., additional, Frazier, T., additional, Frieder, G., additional, Fung, T., additional, Gawinski, G. N., additional, Gibson, C. R., additional, Giraldez, E., additional, Glenn, S. M., additional, Golick, B. P., additional, Gonzales, H., additional, Gonzales, S. A., additional, Gonzales, M. J., additional, Griffin, K. L., additional, Grippen, J., additional, Gross, S. M., additional, Gschweng, P. H., additional, Gururangan, G., additional, Gu, K., additional, Haan, S. W., additional, Hahn, S. R., additional, Haid, B. J., additional, Hamblen, J. E., additional, Hammel, B. A., additional, Hamza, A. V., additional, Hardy, D. L., additional, Hart, D. R., additional, Hartley, R. G., additional, Haynam, C. A., additional, Heestand, G. M., additional, Hermann, M. R., additional, Hermes, G. L., additional, Hey, D. S., additional, Hibbard, R. L., additional, Hicks, D. G., additional, Hinkel, D. E., additional, Hipple, D. L., additional, Hitchcock, J. D., additional, Hodtwalker, D. L., additional, Holder, J. P., additional, Hollis, J. D., additional, Holtmeier, G. M., additional, Huber, S. R., additional, Huey, A. W., additional, Hulsey, D. N., additional, Hunter, S. L., additional, Huppler, T. R., additional, Hutton, M. S., additional, Izumi, N., additional, Jackson, J. L., additional, Jackson, M. A., additional, Jancaitis, K. S., additional, Jedlovec, D. R., additional, Johnson, B., additional, Johnson, M. C., additional, Johnson, T., additional, Johnston, M. P., additional, Jones, O. S., additional, Kalantar, D. H., additional, Kamperschroer, J. H., additional, Kauffman, R. L., additional, Keating, G. A., additional, Kegelmeyer, L. M., additional, Kenitzer, S. L., additional, Kimbrough, J. R., additional, King, K., additional, Kirkwood, R. K., additional, Klingmann, J. L., additional, Knittel, K. M., additional, Kohut, T. R., additional, Koka, K. G., additional, Kramer, S. W., additional, Krammen, J. E., additional, Krauter, K. G., additional, Krauter, G. W., additional, Krieger, E. K., additional, Kroll, J. J., additional, La Fortune, K. N., additional, Lagin, L. J., additional, Lakamsani, V. K., additional, Landen, O. L., additional, Lane, S. W., additional, Langdon, A. B., additional, Langer, S. H., additional, Lao, N., additional, Larson, D. W., additional, Latray, D. A., additional, Lau, G. T., additional, Le Pape, S., additional, Lechleiter, B. L., additional, Lee, Y., additional, Lee, T. L., additional, Li, J., additional, Liebman, J. A., additional, Lindl, J. D., additional, Locke, S. F., additional, Loey, H. K., additional, London, R. A., additional, Lopez, F. J., additional, Lord, D. M., additional, Lowe-Webb, R. R., additional, Lown, J. G., additional, Ludwigsen, A. P., additional, Lum, N. W., additional, Lyons, R. R., additional, Ma, T., additional, MacKinnon, A. J., additional, Magat, M. D., additional, Maloy, D. T., additional, Malsbury, T. N., additional, Markham, G., additional, Marquez, R. M., additional, Marsh, A. A., additional, Marshall, C. D., additional, Marshall, S. R., additional, Maslennikov, I. L., additional, Mathisen, D. G., additional, Mauger, G. J., additional, Mauvais, M.-Y., additional, McBride, J. A., additional, McCarville, T., additional, McCloud, J. B., additional, McGrew, A., additional, McHale, B., additional, MacPhee, A. G., additional, Meeker, J. F., additional, Merill, J. S., additional, Mertens, E. P., additional, Michel, P. A., additional, Miller, M. G., additional, Mills, T. E., additional, Milovich, J. L., additional, Miramontes-Ortiz, R., additional, Montesanti, R. C., additional, Montoya, M. M., additional, Moody, J., additional, Moody, J. D., additional, Moreno, K. A., additional, Morris, J., additional, Morriston, K. M., additional, Nelson, J. R., additional, Neto, M., additional, Neumann, J. D., additional, Ng, E., additional, Ngo, Q. M., additional, Olejniczak, B. L., additional, Olson, R. E., additional, Orsi, N. L., additional, Owens, M. W., additional, Padilla, E. H., additional, Pannell, T. M., additional, Parham, T. G., additional, Patterson, R. W., additional, Pavel, G., additional, Prasad, R. R., additional, Pendleton, D., additional, Penko, F. A., additional, Pepmeier, B. L., additional, Petersen, D. E., additional, Phillips, T. W., additional, Pigg, D., additional, Piston, K. W., additional, Pletcher, K. D., additional, Powell, C. L., additional, Radousky, H. B., additional, Raimondi, B. S., additional, Ralph, J. E., additional, Rampke, R. L., additional, Reed, R. K., additional, Reid, W. A., additional, Rekow, V. V., additional, Reynolds, J. L., additional, Rhodes, J. J., additional, Richardson, M. J., additional, Rinnert, R. J., additional, Riordan, B. P., additional, Rivenes, A. S., additional, Rivera, A. T., additional, Roberts, C. J., additional, Robinson, J. A., additional, Robinson, R. B., additional, Robison, S. R., additional, Rodriguez, O. R., additional, Rogers, S. P., additional, Rosen, M. D., additional, Ross, G. F., additional, Runkel, M., additional, Runtal, A. S., additional, Sacks, R. A., additional, Sailors, S. F., additional, Salmon, J. T., additional, Salmonson, J. D., additional, Saunders, R. L., additional, Schaffer, J. R., additional, Schindler, T. M., additional, Schmitt, M. J., additional, Schneider, M. B., additional, Segraves, K. S., additional, Shaw, M. J., additional, Sheldrick, M. E., additional, Shelton, R. T., additional, Shiflett, M. K., additional, Shiromizu, S. J., additional, Shor, M., additional, Silva, L. L., additional, Silva, S. A., additional, Skulina, K. M., additional, Smauley, D. A., additional, Smith, B. E., additional, Smith, L. K., additional, Solomon, A. L., additional, Sommer, S., additional, Soto, J. G., additional, Spafford, N. I., additional, Speck, D. E., additional, Springer, P. T., additional, Stadermann, M., additional, Stanley, F., additional, Stone, T. G., additional, Stout, E. A., additional, Stratton, P. L., additional, Strauser, R. J., additional, Suter, L. J., additional, Sweet, W., additional, Swisher, M. F., additional, Tappero, J. D., additional, Tassano, J. B., additional, Taylor, J. S., additional, Tekle, E. A., additional, Thai, C., additional, Thomas, C. A., additional, Thomas, A., additional, Throop, A. L., additional, Tietbohl, G. L., additional, Tillman, J. M., additional, Town, R. P. J., additional, Townsend, S. L., additional, Tribbey, K. L., additional, Trummer, D. J., additional, Truong, J. H., additional, Vaher, J. L., additional, Valadez, M. C., additional, Van Arsdall, P. J., additional, Van Prooyen, A. J., additional, Vergel de Dios, E. O., additional, Vergino, M. D., additional, Vernon, S. P., additional, Vickers, J. L., additional, Villanueva, G. T., additional, Vitalich, M. A., additional, Vonhof, S. A., additional, Wade, F. E., additional, Wallace, R. J., additional, Warren, C. T., additional, Warrick, A. L., additional, Watkins, J., additional, Weaver, S., additional, Wegner, P. J., additional, Weingart, M. A., additional, Wen, J., additional, White, K. S., additional, Whitman, P. K., additional, Widmann, K., additional, Widmayer, C. C., additional, Wilhelmsen, K., additional, Williams, E. A., additional, Williams, W. H., additional, Willis, L., additional, Wilson, E. F., additional, Wilson, B. A., additional, Witte, M. C., additional, Work, K., additional, Yang, P. S., additional, Young, B. K., additional, Youngblood, K. P., additional, Zacharias, R. A., additional, Zapata, P. G., additional, Zhang, H., additional, Zielinski, J. S., additional, Kline, J. L., additional, Kyrala, G. A., additional, Niemann, C., additional, Kilkenny, J. D., additional, Nikroo, A., additional, Van Wonterghem, B. M., additional, Atherton, L. J., additional, and Moses, E. I., additional

Published
2011
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15. Demonstration of Ignition Radiation Temperatures in Indirect-Drive Inertial Confinement Fusion Hohlraums

Author

Glenzer, S. H., primary, MacGowan, B. J., additional, Meezan, N. B., additional, Adams, P. A., additional, Alfonso, J. B., additional, Alger, E. T., additional, Alherz, Z., additional, Alvarez, L. F., additional, Alvarez, S. S., additional, Amick, P. V., additional, Andersson, K. S., additional, Andrews, S. D., additional, Antonini, G. J., additional, Arnold, P. A., additional, Atkinson, D. P., additional, Auyang, L., additional, Azevedo, S. G., additional, Balaoing, B. N. M., additional, Baltz, J. A., additional, Barbosa, F., additional, Bardsley, G. W., additional, Barker, D. A., additional, Barnes, A. I., additional, Baron, A., additional, Beeler, R. G., additional, Beeman, B. V., additional, Belk, L. R., additional, Bell, J. C., additional, Bell, P. M., additional, Berger, R. L., additional, Bergonia, M. A., additional, Bernardez, L. J., additional, Berzins, L. V., additional, Bettenhausen, R. C., additional, Bezerides, L., additional, Bhandarkar, S. D., additional, Bishop, C. L., additional, Bond, E. J., additional, Bopp, D. R., additional, Borgman, J. A., additional, Bower, J. R., additional, Bowers, G. A., additional, Bowers, M. W., additional, Boyle, D. T., additional, Bradley, D. K., additional, Bragg, J. L., additional, Braucht, J., additional, Brinkerhoff, D. L., additional, Browning, D. F., additional, Brunton, G. K., additional, Burkhart, S. C., additional, Burns, S. R., additional, Burns, K. E., additional, Burr, B., additional, Burrows, L. M., additional, Butlin, R. K., additional, Cahayag, N. J., additional, Callahan, D. A., additional, Cardinale, P. S., additional, Carey, R. W., additional, Carlson, J. W., additional, Casey, A. D., additional, Castro, C., additional, Celeste, J. R., additional, Chakicherla, A. Y., additional, Chambers, F. W., additional, Chan, C., additional, Chandrasekaran, H., additional, Chang, C., additional, Chapman, R. F., additional, Charron, K., additional, Chen, Y., additional, Christensen, M. J., additional, Churby, A. J., additional, Clancy, T. J., additional, Cline, B. D., additional, Clowdus, L. C., additional, Cocherell, D. G., additional, Coffield, F. E., additional, Cohen, S. J., additional, Costa, R. L., additional, Cox, J. R., additional, Curnow, G. M., additional, Dailey, M. J., additional, Danforth, P. M., additional, Darbee, R., additional, Datte, P. S., additional, Davis, J. A., additional, Deis, G. A., additional, Demaret, R. D., additional, Dewald, E. L., additional, Di Nicola, P., additional, Di Nicola, J. M., additional, Divol, L., additional, Dixit, S., additional, Dobson, D. B., additional, Doppner, T., additional, Driscoll, J. D., additional, Dugorepec, J., additional, Duncan, J. J., additional, Dupuy, P. C., additional, Dzenitis, E. G., additional, Eckart, M. J., additional, Edson, S. L., additional, Edwards, G. J., additional, Edwards, M. J., additional, Edwards, O. D., additional, Edwards, P. W., additional, Ellefson, J. C., additional, Ellerbee, C. H., additional, Erbert, G. V., additional, Estes, C. M., additional, Fabyan, W. J., additional, Fallejo, R. N., additional, Fedorov, M., additional, Felker, B., additional, Fink, J. T, additional, Finney, M. D., additional, Finnie, L. F., additional, Fischer, M. J., additional, Fisher, J. M., additional, Fishler, B. T., additional, Florio, J. W., additional, Forsman, A., additional, Foxworthy, C. B., additional, Franks, R. M., additional, Frazier, T., additional, Frieder, G., additional, Fung, T., additional, Gawinski, G. N., additional, Gibson, C. R., additional, Giraldez, E., additional, Glenn, S. M., additional, Golick, B. P., additional, Gonzales, H., additional, Gonzales, S. A., additional, Gonzalez, M. J., additional, Griffin, K. L., additional, Grippen, J., additional, Gross, S. M., additional, Gschweng, P. H., additional, Gururangan, G., additional, Gu, K., additional, Haan, S. W., additional, Hahn, S. R., additional, Haid, B. J., additional, Hamblen, J. E., additional, Hammel, B. A., additional, Hamza, A. V., additional, Hardy, D. L., additional, Hart, D. R., additional, Hartley, R. G., additional, Haynam, C. A., additional, Heestand, G. M., additional, Hermann, M. R., additional, Hermes, G. L., additional, Hey, D. S., additional, Hibbard, R. L., additional, Hicks, D. G., additional, Hinkel, D. E., additional, Hipple, D. L., additional, Hitchcock, J. D., additional, Hodtwalker, D. L., additional, Holder, J. P., additional, Hollis, J. D., additional, Holtmeier, G. M., additional, Huber, S. R., additional, Huey, A. W., additional, Hulsey, D. N., additional, Hunter, S. L., additional, Huppler, T. R., additional, Hutton, M. S., additional, Izumi, N., additional, Jackson, J. L., additional, Jackson, M. A., additional, Jancaitis, K. S., additional, Jedlovec, D. R., additional, Johnson, B., additional, Johnson, M. C., additional, Johnson, T., additional, Johnston, M. P., additional, Jones, O. S., additional, Kalantar, D. H., additional, Kamperschroer, J. H., additional, Kauffman, R. L., additional, Keating, G. A., additional, Kegelmeyer, L. M., additional, Kenitzer, S. L., additional, Kimbrough, J. R., additional, King, K., additional, Kirkwood, R. K., additional, Klingmann, J. L., additional, Knittel, K. M., additional, Kohut, T. R., additional, Koka, K. G., additional, Kramer, S. W., additional, Krammen, J. E., additional, Krauter, K. G., additional, Krauter, G. W., additional, Krieger, E. K., additional, Kroll, J. J., additional, La Fortune, K. N., additional, Lagin, L. J., additional, Lakamsani, V. K., additional, Landen, O. L., additional, Lane, S. W., additional, Langdon, A. B., additional, Langer, S. H., additional, Lao, N., additional, Larson, D. W., additional, Latray, D., additional, Lau, G. T., additional, Le Pape, S., additional, Lechleiter, B. L., additional, Lee, Y., additional, Lee, T. L., additional, Li, J., additional, Liebman, J. A., additional, Lindl, J. D., additional, Locke, S. F., additional, Loey, H. K., additional, London, R. A., additional, Lopez, F. J., additional, Lord, D. M., additional, Lowe-Webb, R. R., additional, Lown, J. G., additional, Ludwigsen, A. P., additional, Lum, N. W., additional, Lyons, R. R., additional, Ma, T., additional, MacKinnon, A. J., additional, Magat, M. D., additional, Maloy, D. T., additional, Malsbury, T. N., additional, Markham, G., additional, Marquez, R. M., additional, Marsh, A. A., additional, Marshall, C. D., additional, Marshall, S. R., additional, Maslennikov, I. L., additional, Mathisen, D. G., additional, Mauger, G. J., additional, Mauvais, M. -Y., additional, McBride, J. A., additional, McCarville, T., additional, McCloud, J. B., additional, McGrew, A., additional, McHale, B., additional, MacPhee, A. G., additional, Meeker, J. F., additional, Merill, J. S., additional, Mertens, E. P., additional, Michel, P. A., additional, Miller, M. G., additional, Mills, T., additional, Milovich, J. L., additional, Miramontes, R., additional, Montesanti, R. C., additional, Montoya, M. M., additional, Moody, J., additional, Moody, J. D., additional, Moreno, K. A., additional, Morris, J., additional, Morriston, K. M., additional, Nelson, J. R., additional, Neto, M., additional, Neumann, J. D., additional, Ng, E., additional, Ngo, Q. M., additional, Olejniczak, B. L., additional, Olson, R. E., additional, Orsi, N. L., additional, Owens, M. W., additional, Padilla, E. H., additional, Pannell, T. M., additional, Parham, T. G., additional, Patterson, R. W., additional, Pavel, G., additional, Prasad, R. R., additional, Pendlton, D., additional, Penko, F. A., additional, Pepmeier, B. L., additional, Petersen, D. E., additional, Phillips, T. W., additional, Pigg, D., additional, Piston, K. W., additional, Pletcher, K. D., additional, Powell, C. L., additional, Radousky, H. B., additional, Raimondi, B. S., additional, Ralph, J. E., additional, Rampke, R. L., additional, Reed, R. K., additional, Reid, W. A., additional, Rekow, V. V., additional, Reynolds, J. L., additional, Rhodes, J. J., additional, Richardson, M. J., additional, Rinnert, R. J., additional, Riordan, B. P., additional, Rivenes, A. S., additional, Rivera, A. T., additional, Roberts, C. J., additional, Robinson, J. A., additional, Robinson, R. B., additional, Robison, S. R., additional, Rodriguez, O. R., additional, Rogers, S. P., additional, Rosen, M. D., additional, Ross, G. F., additional, Runkel, M., additional, Runtal, A. S., additional, Sacks, R. A., additional, Sailors, S. F., additional, Salmon, J. T., additional, Salmonson, J. D., additional, Saunders, R. L., additional, Schaffer, J. R., additional, Schindler, T. M., additional, Schmitt, M. J., additional, Schneider, M. B., additional, Segraves, K. S., additional, Shaw, M. J., additional, Sheldrick, M. E., additional, Shelton, R. T., additional, Shiflett, M. K., additional, Shiromizu, S. J., additional, Shor, M., additional, Silva, L. L., additional, Silva, S. A., additional, Skulina, K. M., additional, Smauley, D. A., additional, Smith, B. E., additional, Smith, L. K., additional, Solomon, A. L., additional, Sommer, S., additional, Soto, J. G., additional, Spafford, N. I., additional, Speck, D. E., additional, Springer, P. T., additional, Stadermann, M., additional, Stanley, F., additional, Stone, T. G., additional, Stout, E. A., additional, Stratton, P. L., additional, Strausser, R. J., additional, Suter, L. J., additional, Sweet, W., additional, Swisher, M. F., additional, Tappero, J. D., additional, Tassano, J. B., additional, Taylor, J. S., additional, Tekle, E. A., additional, Thai, C., additional, Thomas, C. A., additional, Thomas, A., additional, Throop, A. L., additional, Tietbohl, G. L., additional, Tillman, J. M., additional, Town, R. P. J., additional, Townsend, S. L., additional, Tribbey, K. 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Published
2011
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16. Epo-induced erythroid maturation is dependent on Plcγ1 signaling.

Author

Schnöder, T M, Arreba-Tutusaus, P, Griehl, I, Bullinger, L, Buschbeck, M, Lane, S W, Döhner, K, Plass, C, Lipka, D B, Heidel, F H, and Fischer, T

Subjects
ERYTHROPOIESIS, HEMATOPOIETIC stem cells, ERYTHROCYTES, JANUS kinases, PROTEIN-tyrosine kinases, CELL differentiation, DNA methylation
Abstract

Erythropoiesis is a tightly regulated process. Development of red blood cells occurs through differentiation of hematopoietic stem cells (HSCs) into more committed progenitors and finally into erythrocytes. Binding of erythropoietin (Epo) to its receptor (EpoR) is required for erythropoiesis as it promotes survival and late maturation of erythroid progenitors. In vivo and in vitro studies have highlighted the requirement of EpoR signaling through Janus kinase 2 (Jak2) tyrosine kinase and Stat5a/b as a central pathway. Here, we demonstrate that phospholipase C gamma 1 (Plcγ1) is activated downstream of EpoR-Jak2 independently of Stat5. Plcγ1-deficient pro-erythroblasts and erythroid progenitors exhibited strong impairment in differentiation and colony-forming potential. In vivo, suppression of Plcγ1 in immunophenotypically defined HSCs (Lin−Sca1+KIT+CD48−CD150+) severely reduced erythroid development. To identify Plcγ1 effector molecules involved in regulation of erythroid differentiation, we assessed changes occurring at the global transcriptional and DNA methylation level after inactivation of Plcγ1. The top common downstream effector was H2afy2, which encodes for the histone variant macroH2A2 (mH2A2). Inactivation of mH2A2 expression recapitulated the effects of Plcγ1 depletion on erythroid maturation. Taken together, our findings identify Plcγ1 and its downstream target mH2A2, as a 'non-canonical' Epo signaling pathway essential for erythroid differentiation. [ABSTRACT FROM AUTHOR]

Published
2015
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18. Integration of biology, mathematics and computing in the classroom through the creation and repeated use of transdisciplinary modules.

Author

Ayalew M, Hylton D, Sistrunk J, Melton J, Johnson K, and Voit E

Abstract

The integration of biology with mathematics and computer science mandates the training of students capable of comfortably navigating among these fields. We address this formidable pedagogical challenge with the creation of transdisciplinary modules that guide students toward solving realistic problems with methods from different disciplines. Knowledge is gradually integrated as the same topic is revisited in biology, mathematics, and computer science courses. We illustrate this process with a module on the homeostasis and dynamic regulation of red blood cell production, which was first implemented in an introductory biology course and will be revisited in the mathematics and computer science curricula.

Published
2022
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19. A Brief Report on the Factor Structure of the Cognitive Measures in the HRS/AHEAD Studies.

Author

Blankson AN and McArdle JJ

Abstract

Using cognitive data from the Health and Retirement Study and Asset Health Dynamics Among the Oldest Old studies that were collected between 1992 and 2004, McArdle and colleagues (2007) found that a two-factor model (episodic memory and mental status) fit better than a one-factor model. The question that was addressed in the present study was whether these results would replicate in newer cohorts of data, collected between 2006 and 2010. We also tested age, education, and gender as predictors of the identified factors. Results confirm that a two-factor structure fits better than the single-factor model in the newer cohorts. Differential predictors were also observed.

Published
2014
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