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1. Preparing for responsive management versus preparing for renal dialysis in multimorbid older people with advanced chronic kidney disease (Prepare for Kidney Care): Study protocol for a randomised controlled trial.

Author

Worthington, Jo, Soundy, Alexandra, Frost, Jessica, Rooshenas, Leila, MacNeill, Stephanie J., Realpe Rojas, Alba, Garfield, Kirsty, Liu, Yumeng, Alloway, Karen, Ben-Shlomo, Yoav, Burns, Aine, Chilcot, Joseph, Darling, Jos, Davies, Simon, Farrington, Ken, Gibson, Andrew, Husbands, Samantha, Huxtable, Richard, McNally, Helen, Murphy, Emma, Murtagh, Fliss E. M., Rayner, Hugh, Rice, Caoimhe T., Roderick, Paul, Salisbury, Chris, Taylor, Jodi, Winton, Helen, Donovan, Jenny, Coast, Joanna, Lane, J Athene, and Caskey, Fergus J.

Published
2024
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3. A Genetic Risk Score to Personalize Prostate Cancer Screening, Applied to Population Data

Author

Huynh-Le, Minh-Phuong, Fan, Chun Chieh, Karunamuni, Roshan, Walsh, Eleanor I, Turner, Emma L, Lane, J Athene, Martin, Richard M, Neal, David E, Donovan, Jenny L, Hamdy, Freddie C, Parsons, J Kellogg, Eeles, Rosalind A, Easton, Douglas F, Kote-Jarai, Zsofia, Al Olama, Ali Amin, Garcia, Sara Benlloch, Muir, Kenneth, Grönberg, Henrik, Wiklund, Fredrik, Aly, Markus, Schleutker, Johanna, Sipeky, Csilla, Tammela, Teuvo LJ, Nordestgaard, Børge Grønne, Key, Timothy J, Travis, Ruth C, Pharoah, Paul DP, Pashayan, Nora, Khaw, Kay-Tee, Thibodeau, Stephen N, McDonnell, Shannon K, Schaid, Daniel J, Maier, Christiane, Vogel, Walther, Luedeke, Manuel, Herkommer, Kathleen, Kibel, Adam S, Cybulski, Cezary, Wokolorczyk, Dominika, Kluzniak, Wojciech, Cannon-Albright, Lisa A, Brenner, Hermann, Schöttker, Ben, Holleczek, Bernd, Park, Jong Y, Sellers, Thomas A, Lin, Hui-Yi, Slavov, Chavdar Kroumov, Kaneva, Radka P, Mitev, Vanio I, Batra, Jyotsna, Clements, Judith A, Spurdle, Amanda B, BioResource, for the Australian Prostate Cancer, Teixeira, Manuel R, Paulo, Paula, Maia, Sofia, Pandha, Hardev, Michael, Agnieszka, Mills, Ian G, Andreassen, Ole A, Dale, Anders M, Seibert, Tyler M, and Consortium, for the PRACTICAL

Subjects
Biomedical and Clinical Sciences, Health Sciences, Clinical Sciences, Oncology and Carcinogenesis, Urologic Diseases, Prostate Cancer, Cancer, Aging, Prevention, 4.4 Population screening, Good Health and Well Being, Aged, Early Detection of Cancer, Humans, Male, Middle Aged, Neoplasm Grading, Population Control, Prostatic Neoplasms, Australian Prostate Cancer BioResource, PRACTICAL Consortium, Medical and Health Sciences, Epidemiology, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundA polygenic hazard score (PHS), the weighted sum of 54 SNP genotypes, was previously validated for association with clinically significant prostate cancer and for improved prostate cancer screening accuracy. Here, we assess the potential impact of PHS-informed screening.MethodsUnited Kingdom population incidence data (Cancer Research United Kingdom) and data from the Cluster Randomized Trial of PSA Testing for Prostate Cancer were combined to estimate age-specific clinically significant prostate cancer incidence (Gleason score ≥7, stage T3-T4, PSA ≥10, or nodal/distant metastases). Using HRs estimated from the ProtecT prostate cancer trial, age-specific incidence rates were calculated for various PHS risk percentiles. Risk-equivalent age, when someone with a given PHS percentile has prostate cancer risk equivalent to an average 50-year-old man (50-year-standard risk), was derived from PHS and incidence data. Positive predictive value (PPV) of PSA testing for clinically significant prostate cancer was calculated using PHS-adjusted age groups.ResultsThe expected age at diagnosis of clinically significant prostate cancer differs by 19 years between the 1st and 99th PHS percentiles: men with PHS in the 1st and 99th percentiles reach the 50-year-standard risk level at ages 60 and 41, respectively. PPV of PSA was higher for men with higher PHS-adjusted age.ConclusionsPHS provides individualized estimates of risk-equivalent age for clinically significant prostate cancer. Screening initiation could be adjusted by a man's PHS.ImpactPersonalized genetic risk assessments could inform prostate cancer screening decisions.

Published
2020

6. The associations of anthropometric, behavioural and sociodemographic factors with circulating concentrations of IGF‐I, IGF‐II, IGFBP‐1, IGFBP‐2 and IGFBP‐3 in a pooled analysis of 16,024 men from 22 studies

Author

Watts, Eleanor L, Perez‐Cornago, Aurora, Appleby, Paul N, Albanes, Demetrius, Ardanaz, Eva, Black, Amanda, Bueno‐de‐Mesquita, H Bas, Chan, June M, Chen, Chu, Chubb, SA Paul, Cook, Michael B, Deschasaux, Mélanie, Donovan, Jenny L, English, Dallas R, Flicker, Leon, Freedman, Neal D, Galan, Pilar, Giles, Graham G, Giovannucci, Edward L, Gunter, Marc J, Habel, Laurel A, Häggström, Christel, Haiman, Christopher, Hamdy, Freddie C, Hercberg, Serge, Holly, Jeff M, Huang, Jiaqi, Huang, Wen‐Yi, Johansson, Mattias, Kaaks, Rudolf, Kubo, Tatsuhiko, Lane, J Athene, Layne, Tracy M, Le Marchand, Loic, Martin, Richard M, Metter, E Jeffrey, Mikami, Kazuya, Milne, Roger L, Morris, Howard A, Mucci, Lorelei A, Neal, David E, Neuhouser, Marian L, Oliver, Steven E, Overvad, Kim, Ozasa, Kotaro, Pala, Valeria, Pernar, Claire H, Pollak, Michael, Rowlands, Mari‐Anne, Schaefer, Catherine A, Schenk, Jeannette M, Stattin, Pär, Tamakoshi, Akiko, Thysell, Elin, Touvier, Mathilde, Trichopoulou, Antonia, Tsilidis, Konstantinos K, Van Den Eeden, Stephen K, Weinstein, Stephanie J, Wilkens, Lynne, Yeap, Bu B, Key, Timothy J, Allen, Naomi E, and Travis, Ruth C

Subjects
Cancer, Aging, Urologic Diseases, Adult, Aged, Aged, 80 and over, Anthropometry, Biomarkers, Tumor, Cross-Sectional Studies, Humans, Insulin-Like Growth Factor Binding Proteins, Insulin-Like Growth Factor I, Insulin-Like Growth Factor II, Male, Middle Aged, Neoplasms, Prospective Studies, Young Adult, IGFs, IGFBPs, pooled analysis, correlates, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

Insulin-like growth factors (IGFs) and insulin-like growth factor binding proteins (IGFBPs) have been implicated in the aetiology of several cancers. To better understand whether anthropometric, behavioural and sociodemographic factors may play a role in cancer risk via IGF signalling, we examined the cross-sectional associations of these exposures with circulating concentrations of IGFs (IGF-I and IGF-II) and IGFBPs (IGFBP-1, IGFBP-2 and IGFBP-3). The Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group dataset includes individual participant data from 16,024 male controls (i.e. without prostate cancer) aged 22-89 years from 22 prospective studies. Geometric means of protein concentrations were estimated using analysis of variance, adjusted for relevant covariates. Older age was associated with higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGF-I, IGF-II and IGFBP-3. Higher body mass index was associated with lower concentrations of IGFBP-1 and IGFBP-2. Taller height was associated with higher concentrations of IGF-I and IGFBP-3 and lower concentrations of IGFBP-1. Smokers had higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGFBP-3 than nonsmokers. Higher alcohol consumption was associated with higher concentrations of IGF-II and lower concentrations of IGF-I and IGFBP-2. African Americans had lower concentrations of IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 and Hispanics had lower IGF-I, IGF-II and IGFBP-3 than non-Hispanic whites. These findings indicate that a range of anthropometric, behavioural and sociodemographic factors are associated with circulating concentrations of IGFs and IGFBPs in men, which will lead to a greater understanding of the mechanisms through which these factors influence cancer risk.

Published
2019

11. The high-volume haemodiafiltration vs high-flux haemodialysis registry trial (H4RT): a multi-centre, unblinded, randomised, parallel-group, superiority study to compare the effectiveness and cost-effectiveness of high-volume haemodiafiltration and high-flux haemodialysis in people with kidney failure on maintenance dialysis using linkage to routine healthcare databases for outcomes

Author

Caskey, Fergus J., Procter, Sunita, MacNeill, Stephanie J., Wade, Julia, Taylor, Jodi, Rooshenas, Leila, Liu, Yumeng, Annaw, Ammar, Alloway, Karen, Davenport, Andrew, Power, Albert, Farrington, Ken, Mitra, Sandip, Wheeler, David C., Law, Kristian, Lewis-White, Helen, Ben-Shlomo, Yoav, Hollingworth, Will, Donovan, Jenny, and Lane, J. Athene

Published
2022
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12. Prostate cancer–Exercise and Metformin Trial (Pre-EMpT): study protocol for a feasibility factorial randomized controlled trial in men with localised or locally advanced prostate cancer

Author

McGeagh, Lucy, Robles, Luke A., Persad, Raj, Rowe, Edward, Bahl, Amit, Aning, Jonathan, Koupparis, Anthony, Abrams, Paul, Perks, Claire, Holly, Jeffrey, Johnson, Lyndsey, Shiridzinomwa, Constance, Challapalli, Amarnath, Shingler, Ellie, Taylor, Hilary, Oxley, Jon, Sandu, Meda, Martin, Richard M., and Lane, J. Athene

Published
2022
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14. Thulium laser transurethral vaporesection of the prostate versus transurethral resection of the prostate for men with lower urinary tract symptoms or urinary retention (UNBLOCS): a randomised controlled trial

Author

Beck, Rupert, Blake, Christopher, Davenport, Kim, Kayes, Oliver, Sullivan, Jonathan, Cohen, Nicholas, Murugesan, Mathialagan, Timoney, Anthony, Johnson, Lyndsey, Adams, Benita, Allan, Angela, Brain, Carol, Hammonds, Fiona, Henderson, Joan, Hilltout, Paula, Kilbane, Bernadette, Morrison, Leigh, Robson, Wendy, Wiseman, Lorraine, Zinyemba, Vivian, Metcalfe, Chris, Khan, Rafiyah, Uren, Alan, Ahern, Aideen, Moure Fernandez, Aida, Warnes, Barbara, Steuart-Feilding, Tom, Pawsey, Christopher, Plant, Julie, Baquedano, Mai, Carmichael, David, Hashim, Hashim, Worthington, Jo, Abrams, Paul, Young, Grace, Taylor, Hilary, Noble, Sian M, Brookes, Sara T, Cotterill, Nikki, Page, Tobias, Swami, K Satchi, and Lane, J Athene

Published
2020
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15. Ten-year Mortality, Disease Progression, and Treatment-related Side Effects in Men with Localised Prostate Cancer from the ProtecT Randomised Controlled Trial According to Treatment Received

Author

Hamdy, Freddie C., Donovan, Jenny L., Neal, David E., Lane, J. Athene, Metcalfe, Chris, Peters, Tim J., Bollina, Prasad, Doble, Andrew, Doherty, Alan, Gnanapragasam, Vincent, Hughes, Owen, Gillatt, David, Kockelbergh, Roger, Kynaston, Howard, Paul, Alan, Paez, Edgar, Powell, Philip, Prescott, Stephen, Rosario, Derek, Rowe, Edward, Anderson, John B., Aning, Jonathan, Catto, James, Durkan, Garett, Koupparis, Anthony, Leung, Hing, Mariappan, Param, McNeill, Alan, Persad, Raj, Schwaibold, Hartwig, Tulloch, David, Wallace, Michael, Bonnington, Susan, Bradshaw, Lynne, Cooper, Deborah, Elliott, Emma, Herbert, Phillipa, Holding, Peter, Howson, Joanne, Jones, Amanda, Lennon, Teresa, Lyons, Norma, Moody, Hilary, Plumb, Claire, O'Sullivan, Tricia, Salter, Elizabeth, Thompson, Pauline, Tidball, Sarah, Blaikie, Jan, Gray, Catherine, Adam, Tonia, Askew, Sarah, Atkinson, Sharon, Baynes, Tim, Brain, Carole, Breen, Viv, Brunt, Sarah, Bryne, Sean, Bythem, Jo, Clarke, Jenny, Cloete, Jenny, Dark, Susan, Davis, Gill, Rue, Rachael De La, Denizot, Jane, Dewhurst, Elspeth, Dimes, Anna, Dixon, Nicola, Ebbs, Penny, Emmerson, Ingrid, Ferguson, Jill, Gadd, Ali, Geoghegan, Lisa, Grant, Alison, Grant, Collette, Godfrey, Rosemary, Goodwin, Louise, Hall, Susie, Hart, Liz, Harvey, Andrew, Hoult, Chloe, Hawkins, Sarah, Holling, Sharon, Innes, Alastair, Kilner, Sue, Marshall, Fiona, Mellen, Louise, Moore, Andrea, Napier, Sally, Needham, Julie, Pearse, Kevin, Pisa, Anna, Rees, Mark, Richards, Ellie, Robson, Lindsay, Roxburgh, Janet, Samuel, Nikki, Sharkey, Irene, Slater, Michael, Smith, Donna, Taggart, Pippa, Taylor, Helen, Taylor, Vicky, Thomas, Ayesha, Tomkies, Briony, Trewick, Nicola, Ward, Claire, Walker, Christy, Williams, Ayesha, Woodhouse, Colin, Wyber, Elizabeth, Mason, Malcolm, Bahl, Amit, Benson, Richard, Beresford, Mark, Ferguson, Catherine, Graham, John, Herbert, Chris, Howard, Grahame, James, Nick, Kirkbride, Peter, Law, Alastair, Loughrey, Carmel, McClaren, Duncan, Patterson, Helen, Pedley, Ian, Roberts, Trevor, Robinson, Angus, Russell, Simon, Staffurth, John, Symonds, Paul, Thanvi, Narottam, Vasanthan, Subramaniam, Wilson, Paula, Oxley, Jon, Robinson, Mary, Bhattarai, Selina, Deshmukh, Neeta, Dormer, John, Fernando, Malee, Goepel, John, Griffiths, David, Grigor, Ken, Mayer, Nick, Varma, Murali, Warren, Anne, Appleby, Helen, Ash, Dominic, Aston, Dean, Bolton, Steven, Chalmers, Graham, Conway, John, Early, Nick, Geater, Tony, Goddall, Lynda, Heymann, Claire, Hicks, Deborah, Jones, Liza, Lamb, Susan, Lambert, Geoff, Lawrence, Gill, Lewis, Geraint, Lilley, John, MacLeod, Aileen, Massey, Pauline, McQueen, Alison, Moore, Rollo, Penketh, Lynda, Potterton, Janet, Roberts, Neil, Showler, Helen, Shuttleworth, Pam, Slade, Stephen, Steele, Alasdair, Swinscoe, James, Tiffany, Marie, Townley, John, Treeby, Jo, Weston, Michael, Wilkinson, Joyce, Williams, Lorraine, Wills, Lucy, Woodley, Owain, Yarrow, Sue, Brindle, Lucy, Davies, Linda, Davis, Michael, Dedman, Dan, Down, Elizabeth, Khazragui, Hanan, Martin, Richard M., Noble, Sian, Taylor, Hilary, Tazewell, Marta, Turner, Emma L., Wade, Julia, Walsh, Eleanor, Baker, Susan, Bellis-Sheldon, Elizabeth, Bougard, Chantal, Bowtell, Joanne, Brewer, Catherine, Burton, Chris, Charlton, Jennie, Christoforou, Nicholas, Clark, Rebecca, Coull, Susan, Croker, Christine, Currer, Rosemary, Daisey, Claire, Delaney, Gill, Donohue, Rose, Drew, Jane, Farmer, Rebecca, Fry, Susan, Haddow, Jean, Hale, Alex, Halpin, Susan, Harris, Belle, Hattrick, Barbara, Holmes, Sharon, Hunt, Helen, Jackson, Vicky, Johnson, Donna, Le Butt, Mandy, Leworthy, Jo, Liddiatt, Tanya, Martin, Alex, Mauree, Jainee, Moore, Susan, Moulam, Gill, Mutch, Jackie, Parker, Kathleen, Pawsey, Christopher, Purdie, Michelle, Robson, Teresa, Smith, Lynne, Stenton, Carole, Steuart-Feilding, Tom, Stott, Beth, Sully, Chris, Sutton, Caroline, Torrington, Carol, Wilkins, Zoe, Williams, Sharon, Wilson, Andrea, Weaver, Ashleigh, Albertsen, Peter, Adolfsson, Jan, Baum, Michael, McFarlane, Jon, Reid, Colette, Turner, Emma, Zietman, Anthony, Hill, Elizabeth, Ng, Siaw Yein, Williams, Naomi, Toole, Jessica, Davies, Charlotte, Hughes, Laura, Rowlands, Mari-Anne, Bell, Lindsey, Harrison, Sean, Mauree, Jainnee, Grant, Adrian, Roberts, Ian, Ashby, Deborah, Cowan, Richard, Fayers, Peter, Mellon, Killian, N’Dow, James, O’Brien, Tim, Sokhal, Michael, Dearnaley, David, Schröder, Fritz, Roberts, Tracy, Young, Grace J., Dutton, Susan J., Walsh, Eleanor I., Peters, Tim. J., Bryant, Richard, Rosario, Derek J., and Altman, Doug G.

Published
2020
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16. Factors associated with trial recruitment, preferences, and treatments received were elucidated in a comprehensive cohort study

Author

Holding, Peter, Mason, Malcolm, Catto, James W.F., Rosario, Derek J., Staffurth, John, Kynaston, Howard, Hughes, Owen, Bollina, Prasad, Doherty, Alan, Gnanapragasam, Vincent, Kockelbergh, Roger, Paul, Alan, Paez, Edgar, Gillatt, David, Rowe, Edward, Oxley, Jon, Donovan, Jenny L., Opmeer, Brent, Young, Grace J., Mills, Nicola, Martin, Richard M., Lane, J. Athene, Metcalfe, Chris, Peters, Tim J., Davis, Michael, Turner, Emma L., Walsh, Eleanor, Neal, David E., and Hamdy, Freddie C.

Published
2019
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17. Clinical and Patient-reported Outcome Measures in Men Referred for Consideration of Surgery to Treat Lower Urinary Tract Symptoms: Baseline Results and Diagnostic Findings of the Urodynamics for Prostate Surgery Trial; Randomised Evaluation of Assessment Methods (UPSTREAM)

Author

Lewis, Amanda L., Young, Grace J., Abrams, Paul, Blair, Peter S., Chapple, Christopher, Glazener, Cathryn M.A., Horwood, Jeremy, McGrath, John S., Noble, Sian, Taylor, Gordon T., Ito, Hiroki, Belal, Mohammed, Davies, Melissa C., Dickinson, Andrew J., Foley, Charlotte L., Foley, Steve, Fulford, Simon, Gammal, Mohsen M., Garthwaite, Mary, Harris, Mark R.E., Ilie, Petre C., Jones, Robert, Sabbagh, Samer, Mason, Robert G., McLarty, Ester, Mishra, Vibhash, Mom, Jaswant, Morley, Roland, Natale, Salvatore, Nitkunan, Tharani, Page, Tobias, Payne, David, Rashid, Tina G., Saeb-Parsy, Kasra, Sandhu, Sarb S., Simoes, Adrian, Singh, Gurpreet, Sullivan, Mark, Tempest, Heidi V., Viswanath, Srinivasa, Walker, Roger M.H., Lane, J. Athene, and Drake, Marcus J.

Published
2019
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19. A prospective cohort and extended comprehensive-cohort design provided insights about the generalizability of a pragmatic trial: the ProtecT prostate cancer trial

Author

Bollina, Prasad, Catto, James, Doble, Andrew, Doherty, Alan, Gillatt, David, Gnanapragasam, Vincent, Holding, Peter, Hughes, Owen, Kockelbergh, Roger, Kynaston, Howard, Mason, Malcolm, Oxley, Jon, Paul, Alan, Paez, Edgar, Rosario, Derek J., Rowe, Edward, Staffurth, John, Donovan, Jenny L., Young, Grace J., Walsh, Eleanor I., Metcalfe, Chris, Lane, J. Athene, Martin, Richard M., Tazewell, Marta K., Davis, Michael, Peters, Tim J., Turner, Emma L., Mills, Nicola, Khazragui, Hanan, Khera, Tarnjit K., Neal, David E., and Hamdy, Freddie C.

Published
2018
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23. How surgical Trainee Research Collaboratives achieve success: a mixed methods study to develop trainee engagement strategies

Author

Clement, Clare, primary, Coulman, Karen, additional, Heywood, Nick, additional, Pinkney, Tom, additional, Blazeby, Jane, additional, Blencowe, Natalie S, additional, Cook, Jonathan Alistair, additional, Bulbulia, Richard, additional, Arenas-Pinto, Alejandro, additional, Snowdon, Claire, additional, Hilton, Zoe, additional, Magill, Laura, additional, MacLennan, Graeme, additional, Glasbey, James, additional, Nepogodiev, Dmitri, additional, Hardy, Victoria, additional, and Lane, J Athene, additional

Published
2023
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24. Treatment of lower urinary tract symptoms in men in primary care using a conservative intervention: cluster randomised controlled trial

Author

Drake, Marcus J, primary, Worthington, Jo, additional, Frost, Jessica, additional, Sanderson, Emily, additional, Cochrane, Madeleine, additional, Cotterill, Nikki, additional, Fader, Mandy, additional, McGeagh, Lucy, additional, Hashim, Hashim, additional, Macaulay, Margaret, additional, Rees, Jonathan, additional, Robles, Luke A, additional, Taylor, Gordon, additional, Taylor, Jodi, additional, Ridd, Matthew J, additional, MacNeill, Stephanie J, additional, Noble, Sian, additional, and Lane, J Athene, additional

Published
2023
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25. Comparison of lotions, creams, gels and ointments for the treatment of childhood eczema: the BEE RCT

Author

Ridd, Matthew J, primary, Wells, Sian, additional, MacNeill, Stephanie J, additional, Sanderson, Emily, additional, Webb, Douglas, additional, Banks, Jonathan, additional, Sutton, Eileen, additional, Shaw, Alison RG, additional, Wilkins, Zoe, additional, Clayton, Julie, additional, Roberts, Amanda, additional, Garfield, Kirsty, additional, Liddiard, Lyn, additional, Barrett, Tiffany J, additional, Lane, J Athene, additional, Baxter, Helen, additional, Howells, Laura, additional, Taylor, Jodi, additional, Hay, Alastair D, additional, Williams, Hywel C, additional, Thomas, Kim S, additional, and Santer, Miriam, additional

Published
2023
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26. Prostate-Specific Antigen Screening and 15-Year Prostate Cancer Mortality: A Secondary Analysis of the CAP Randomized Clinical Trial.

Author

Martin, Richard M., Turner, Emma L., Young, Grace J., Metcalfe, Chris, Walsh, Eleanor I., Lane, J. Athene, Sterne, Jonathan A. C., Noble, Sian, Holding, Peter, Ben-Shlomo, Yoav, Williams, Naomi J., Pashayan, Nora, Bui, Mai Ngoc, Albertsen, Peter C., Seibert, Tyler M., Zietman, Anthony L., Oxley, Jon, Adolfsson, Jan, Mason, Malcolm D., and Davey Smith, George

Abstract

This secondary analysis of a randomized clinical trial assesses whether screening for prostate-specific antigen reduces prostate cancer mortality at 15-year follow-up. Key Points: Question: In men aged 50 to 69 years, does a single invitation for a prostate-specific antigen (PSA) screening test reduce prostate cancer mortality at 15-year follow-up compared with no invitation for testing? Findings: In this secondary analysis of a randomized clinical trial of 415 357 men aged 50 to 69 years randomized to a single invitation for PSA screening (n = 195 912) or a control group without PSA screening (n = 219 445) and followed up for a median of 15 years, risk of death from prostate cancer was lower in the group invited to screening (0.69% vs 0.78%; mean difference, 0.09%) compared with the control group. Meaning: Compared with no invitation for routine PSA testing, a single invitation for a PSA screening test reduced prostate cancer mortality at a median follow-up of 15 years, but the absolute mortality benefit was small. Importance: The Cluster Randomized Trial of PSA Testing for Prostate Cancer (CAP) reported no effect of prostate-specific antigen (PSA) screening on prostate cancer mortality at a median 10-year follow-up (primary outcome), but the long-term effects of PSA screening on prostate cancer mortality remain unclear. Objective: To evaluate the effect of a single invitation for PSA screening on prostate cancer–specific mortality at a median 15-year follow-up compared with no invitation for screening. Design, Setting, and Participants: This secondary analysis of the CAP randomized clinical trial included men aged 50 to 69 years identified at 573 primary care practices in England and Wales. Primary care practices were randomized between September 25, 2001, and August 24, 2007, and men were enrolled between January 8, 2002, and January 20, 2009. Follow-up was completed on March 31, 2021. Intervention: Men received a single invitation for a PSA screening test with subsequent diagnostic tests if the PSA level was 3.0 ng/mL or higher. The control group received standard practice (no invitation). Main Outcomes and Measures: The primary outcome was reported previously. Of 8 prespecified secondary outcomes, results of 4 were reported previously. The 4 remaining prespecified secondary outcomes at 15-year follow-up were prostate cancer–specific mortality, all-cause mortality, and prostate cancer stage and Gleason grade at diagnosis. Results: Of 415 357 eligible men (mean [SD] age, 59.0 [5.6] years), 98% were included in these analyses. Overall, 12 013 and 12 958 men with a prostate cancer diagnosis were in the intervention and control groups, respectively (15-year cumulative risk, 7.08% [95% CI, 6.95%-7.21%] and 6.94% [95% CI, 6.82%-7.06%], respectively). At a median 15-year follow-up, 1199 men in the intervention group (0.69% [95% CI, 0.65%-0.73%]) and 1451 men in the control group (0.78% [95% CI, 0.73%-0.82%]) died of prostate cancer (rate ratio [RR], 0.92 [95% CI, 0.85-0.99]; P =.03). Compared with the control, the PSA screening intervention increased detection of low-grade (Gleason score [GS] ≤6: 2.2% vs 1.6%; P <.001) and localized (T1/T2: 3.6% vs 3.1%; P <.001) disease but not intermediate (GS of 7), high-grade (GS ≥8), locally advanced (T3), or distally advanced (T4/N1/M1) tumors. There were 45 084 all-cause deaths in the intervention group (23.2% [95% CI, 23.0%-23.4%]) and 50 336 deaths in the control group (23.3% [95% CI, 23.1%-23.5%]) (RR, 0.97 [95% CI, 0.94-1.01]; P =.11). Eight of the prostate cancer deaths in the intervention group (0.7%) and 7 deaths in the control group (0.5%) were related to a diagnostic biopsy or prostate cancer treatment. Conclusions and Relevance: In this secondary analysis of a randomized clinical trial, a single invitation for PSA screening compared with standard practice without routine screening reduced prostate cancer deaths at a median follow-up of 15 years. However, the absolute reduction in deaths was small. Trial Registration: isrctn.org Identifier: ISRCTN92187251 [ABSTRACT FROM AUTHOR]

Published
2024
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27. Mortality Among Men with Advanced Prostate Cancer Excluded from the ProtecT Trial

Author

Johnston, Thomas J., Shaw, Greg L., Lamb, Alastair D., Parashar, Deepak, Greenberg, David, Xiong, Tengbin, Edwards, Alison L., Gnanapragasam, Vincent, Holding, Peter, Herbert, Phillipa, Davis, Michael, Mizielinsk, Elizabeth, Lane, J. Athene, Oxley, Jon, Robinson, Mary, Mason, Malcolm, Staffurth, John, Bollina, Prasad, Catto, James, Doble, Andrew, Doherty, Alan, Gillatt, David, Kockelbergh, Roger, Kynaston, Howard, Prescott, Steve, Paul, Alan, Powell, Philip, Rosario, Derek, Rowe, Edward, Donovan, Jenny L., Hamdy, Freddie C., and Neal, David E.

Published
2017
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30. TReatIng Urinary symptoms in Men in Primary Healthcare using non-pharmacological and non-surgical interventions (TRIUMPH) compared with usual care: study protocol for a cluster randomised controlled trial

Author

Frost, Jessica, Lane, J. Athene, Cotterill, Nikki, Fader, Mandy, Hackshaw-McGeagh, Lucy, Hashim, Hashim, Macaulay, Margaret, MacNeill, Stephanie J., Noble, Sian, Rees, Jonathan, Ridd, Matthew J., Robles, Luke, Taylor, Gordon, Taylor, Jodi, Drake, Marcus J, and Worthington, Jo

Published
2019
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31. Lower urinary tract symptoms in men: the TRIUMPH cluster RCT.

Author

Worthington, Jo, Frost, Jessica, Sanderson, Emily, Cochrane, Madeleine, Wheeler, Jessica, Cotterill, Nikki, MacNeill, Stephanie J., Noble, Sian, Avery, Miriam, Clarke, Samantha, Fader, Mandy, Hashim, Hashim, McGeagh, Lucy, Macaulay, Margaret, Rees, Jonathan, Robles, Luke, Taylor, Gordon, Taylor, Jodi, Thompson, Joanne, and Lane, J. Athene

Published
2024

32. Fifteen-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Prostate Cancer

Author

Hamdy, Freddie C., primary, Donovan, Jenny L., additional, Lane, J. Athene, additional, Metcalfe, Chris, additional, Davis, Michael, additional, Turner, Emma L., additional, Martin, Richard M., additional, Young, Grace J., additional, Walsh, Eleanor I., additional, Bryant, Richard J., additional, Bollina, Prasad, additional, Doble, Andrew, additional, Doherty, Alan, additional, Gillatt, David, additional, Gnanapragasam, Vincent, additional, Hughes, Owen, additional, Kockelbergh, Roger, additional, Kynaston, Howard, additional, Paul, Alan, additional, Paez, Edgar, additional, Powell, Philip, additional, Rosario, Derek J., additional, Rowe, Edward, additional, Mason, Malcolm, additional, Catto, James W.F., additional, Peters, Tim J., additional, Oxley, Jon, additional, Williams, Naomi J., additional, Staffurth, John, additional, and Neal, David E., additional

Published
2023
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33. Supplementary Figure 1 from ProDiet: A Phase II Randomized Placebo-controlled Trial of Green Tea Catechins and Lycopene in Men at Increased Risk of Prostate Cancer

Author

Lane, J. Athene, primary, Er, Vanessa, primary, Avery, Kerry N.L., primary, Horwood, Jeremy, primary, Cantwell, Marie, primary, Caro, Gema P., primary, Crozier, Alan, primary, Smith, George Davey, primary, Donovan, Jenny L., primary, Down, Liz, primary, Hamdy, Freddie C., primary, Gillatt, David, primary, Holly, Jeff, primary, Macefield, Rhiannon, primary, Moody, Hilary, primary, Neal, David E., primary, Walsh, Eleanor, primary, Martin, Richard M., primary, and Metcalfe, Chris, primary

Published
2023
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34. Data from ProDiet: A Phase II Randomized Placebo-controlled Trial of Green Tea Catechins and Lycopene in Men at Increased Risk of Prostate Cancer

Author

Lane, J. Athene, primary, Er, Vanessa, primary, Avery, Kerry N.L., primary, Horwood, Jeremy, primary, Cantwell, Marie, primary, Caro, Gema P., primary, Crozier, Alan, primary, Smith, George Davey, primary, Donovan, Jenny L., primary, Down, Liz, primary, Hamdy, Freddie C., primary, Gillatt, David, primary, Holly, Jeff, primary, Macefield, Rhiannon, primary, Moody, Hilary, primary, Neal, David E., primary, Walsh, Eleanor, primary, Martin, Richard M., primary, and Metcalfe, Chris, primary

Published
2023
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36. Supplementary Table 2 from Adherence to Dietary and Lifestyle Recommendations and Prostate Cancer Risk in the Prostate Testing for Cancer and Treatment (ProtecT) Trial

Author

Er, Vanessa, primary, Lane, J. Athene, primary, Martin, Richard M., primary, Emmett, Pauline, primary, Gilbert, Rebecca, primary, Avery, Kerry N.L., primary, Walsh, Eleanor, primary, Donovan, Jenny L., primary, Neal, David E., primary, Hamdy, Freddie C., primary, and Jeffreys, Mona, primary

Published
2023
Full Text
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37. Supplementary Table 1 from Circulating Folate, Vitamin B12, Homocysteine, Vitamin B12 Transport Proteins, and Risk of Prostate Cancer: a Case-Control Study, Systematic Review, and Meta-analysis

Author

Collin, Simon M., primary, Metcalfe, Chris, primary, Refsum, Helga, primary, Lewis, Sarah J., primary, Zuccolo, Luisa, primary, Smith, George Davey, primary, Chen, Lina, primary, Harris, Ross, primary, Davis, Michael, primary, Marsden, Gemma, primary, Johnston, Carole, primary, Lane, J. Athene, primary, Ebbing, Marta, primary, Bønaa, Kaare Harald, primary, Nygård, Ottar, primary, Ueland, Per Magne, primary, Grau, Maria V., primary, Baron, John A., primary, Donovan, Jenny L., primary, Neal, David E., primary, Hamdy, Freddie C., primary, Smith, A. David, primary, and Martin, Richard M., primary

Published
2023
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38. Supplementary Table 1 from Association of Folate-Pathway Gene Polymorphisms with the Risk of Prostate Cancer: a Population-Based Nested Case-Control Study, Systematic Review, and Meta-analysis

Author

Collin, Simon M., primary, Metcalfe, Chris, primary, Zuccolo, Luisa, primary, Lewis, Sarah J., primary, Chen, Lina, primary, Cox, Angela, primary, Davis, Michael, primary, Lane, J. Athene, primary, Donovan, Jenny, primary, Smith, George Davey, primary, Neal, David E., primary, Hamdy, Freddie C., primary, Gudmundsson, Julius, primary, Sulem, Patrick, primary, Rafnar, Thorunn, primary, Benediktsdottir, Kristrun R., primary, Eeles, Rosalind A., primary, Guy, Michelle, primary, Kote-Jarai, Zsofia, primary, Morrison, Jonathan, primary, Al Olama, Ali Amin, primary, Stefansson, Kari, primary, Easton, Douglas F., primary, and Martin, Richard M., primary

Published
2023
Full Text
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42. Data from Circulating Folate, Vitamin B12, Homocysteine, Vitamin B12 Transport Proteins, and Risk of Prostate Cancer: a Case-Control Study, Systematic Review, and Meta-analysis

Author

Collin, Simon M., primary, Metcalfe, Chris, primary, Refsum, Helga, primary, Lewis, Sarah J., primary, Zuccolo, Luisa, primary, Smith, George Davey, primary, Chen, Lina, primary, Harris, Ross, primary, Davis, Michael, primary, Marsden, Gemma, primary, Johnston, Carole, primary, Lane, J. Athene, primary, Ebbing, Marta, primary, Bønaa, Kaare Harald, primary, Nygård, Ottar, primary, Ueland, Per Magne, primary, Grau, Maria V., primary, Baron, John A., primary, Donovan, Jenny L., primary, Neal, David E., primary, Hamdy, Freddie C., primary, Smith, A. David, primary, and Martin, Richard M., primary

Published
2023
Full Text
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43. Supplementary Table 2 from Circulating Folate, Vitamin B12, Homocysteine, Vitamin B12 Transport Proteins, and Risk of Prostate Cancer: a Case-Control Study, Systematic Review, and Meta-analysis

Author

Collin, Simon M., primary, Metcalfe, Chris, primary, Refsum, Helga, primary, Lewis, Sarah J., primary, Zuccolo, Luisa, primary, Smith, George Davey, primary, Chen, Lina, primary, Harris, Ross, primary, Davis, Michael, primary, Marsden, Gemma, primary, Johnston, Carole, primary, Lane, J. Athene, primary, Ebbing, Marta, primary, Bønaa, Kaare Harald, primary, Nygård, Ottar, primary, Ueland, Per Magne, primary, Grau, Maria V., primary, Baron, John A., primary, Donovan, Jenny L., primary, Neal, David E., primary, Hamdy, Freddie C., primary, Smith, A. David, primary, and Martin, Richard M., primary

Published
2023
Full Text
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45. Data from Association of Folate-Pathway Gene Polymorphisms with the Risk of Prostate Cancer: a Population-Based Nested Case-Control Study, Systematic Review, and Meta-analysis

Author

Collin, Simon M., primary, Metcalfe, Chris, primary, Zuccolo, Luisa, primary, Lewis, Sarah J., primary, Chen, Lina, primary, Cox, Angela, primary, Davis, Michael, primary, Lane, J. Athene, primary, Donovan, Jenny, primary, Smith, George Davey, primary, Neal, David E., primary, Hamdy, Freddie C., primary, Gudmundsson, Julius, primary, Sulem, Patrick, primary, Rafnar, Thorunn, primary, Benediktsdottir, Kristrun R., primary, Eeles, Rosalind A., primary, Guy, Michelle, primary, Kote-Jarai, Zsofia, primary, Morrison, Jonathan, primary, Al Olama, Ali Amin, primary, Stefansson, Kari, primary, Easton, Douglas F., primary, and Martin, Richard M., primary

Published
2023
Full Text
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46. Supplementary Table 1 from Adherence to Dietary and Lifestyle Recommendations and Prostate Cancer Risk in the Prostate Testing for Cancer and Treatment (ProtecT) Trial

Author

Er, Vanessa, primary, Lane, J. Athene, primary, Martin, Richard M., primary, Emmett, Pauline, primary, Gilbert, Rebecca, primary, Avery, Kerry N.L., primary, Walsh, Eleanor, primary, Donovan, Jenny L., primary, Neal, David E., primary, Hamdy, Freddie C., primary, and Jeffreys, Mona, primary

Published
2023
Full Text
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48. Supplementary Table 2 from Association of Folate-Pathway Gene Polymorphisms with the Risk of Prostate Cancer: a Population-Based Nested Case-Control Study, Systematic Review, and Meta-analysis

Author

Collin, Simon M., primary, Metcalfe, Chris, primary, Zuccolo, Luisa, primary, Lewis, Sarah J., primary, Chen, Lina, primary, Cox, Angela, primary, Davis, Michael, primary, Lane, J. Athene, primary, Donovan, Jenny, primary, Smith, George Davey, primary, Neal, David E., primary, Hamdy, Freddie C., primary, Gudmundsson, Julius, primary, Sulem, Patrick, primary, Rafnar, Thorunn, primary, Benediktsdottir, Kristrun R., primary, Eeles, Rosalind A., primary, Guy, Michelle, primary, Kote-Jarai, Zsofia, primary, Morrison, Jonathan, primary, Al Olama, Ali Amin, primary, Stefansson, Kari, primary, Easton, Douglas F., primary, and Martin, Richard M., primary

Published
2023
Full Text
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49. Supplementary Figure 1 from Adherence to Dietary and Lifestyle Recommendations and Prostate Cancer Risk in the Prostate Testing for Cancer and Treatment (ProtecT) Trial

Author

Er, Vanessa, primary, Lane, J. Athene, primary, Martin, Richard M., primary, Emmett, Pauline, primary, Gilbert, Rebecca, primary, Avery, Kerry N.L., primary, Walsh, Eleanor, primary, Donovan, Jenny L., primary, Neal, David E., primary, Hamdy, Freddie C., primary, and Jeffreys, Mona, primary

Published
2023
Full Text
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50. Supplementary Table 3 from Adherence to Dietary and Lifestyle Recommendations and Prostate Cancer Risk in the Prostate Testing for Cancer and Treatment (ProtecT) Trial

Author

Er, Vanessa, primary, Lane, J. Athene, primary, Martin, Richard M., primary, Emmett, Pauline, primary, Gilbert, Rebecca, primary, Avery, Kerry N.L., primary, Walsh, Eleanor, primary, Donovan, Jenny L., primary, Neal, David E., primary, Hamdy, Freddie C., primary, and Jeffreys, Mona, primary

Published
2023
Full Text
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