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10. The Rate of Intrapartum Cesarean Delivery Based on Estimated Fetal Weight in Comparison to Previous Child's Birth Weight.

Author

Kawakita, Tetsuya, Sridhar, Shobha, Mokhtari, Neggin, and Landy, Helain J.

Subjects
BODY weight, CONFIDENCE intervals, PREMATURE infants, MULTIPLE regression analysis, FETAL development, RETROSPECTIVE studies, RISK assessment, COMPARATIVE studies, BIRTH weight, DESCRIPTIVE statistics, CESAREAN section, ODDS ratio, INTRAPARTUM care, LONGITUDINAL method
Abstract

Objective The aim of the study is to examine whether an estimated fetal weight of the current pregnancy greater than previous birth weight is associated with increased odds of intrapartum cesarean delivery. Study Design We conducted a retrospective cohort study of all women who had more than one singleton pregnancy at 23 weeks' gestation or greater at a single labor and delivery unit. We only analyzed the second pregnancy in the dataset. We excluded women who had preterm birth in the second pregnancy. Women were categorized according to the difference between estimated fetal weight and previous birth weight—estimated fetal weight close to previous birth weight within 500 g (similar weight group); estimated fetal weight significantly (more than 500 g) greater than previous birth weight (larger weight group); and estimated fetal weight significantly (more than 500 g) lower than previous birth weight (smaller weight group). The primary outcome was intrapartum cesarean delivery. Multivariable logistic regression was performed to calculate adjusted odds ratios (aORs) with 95% confidence interval (95% confidence interval [CI]) after adjusting for predefined covariates. Results Of 1,887 women, there were 1,415 (75%) in the similar weight group, 384 (20%) in the greater weight group, and 88 (5%) in the smaller weight group. Individuals in the larger weight group compared with those in the similar weight group had higher odds of undergoing intrapartum cesarean delivery (11.2 vs. 4.5%; aOR 2.91; 95% CI 1.91–4.45). The odds of intrapartum cesarean delivery in the smaller weight group compared with those in the similar weight group were not increased (3.4 vs. 4.5%; crude OR 0.75; 95%CI 0.23–2.42). Conclusion The difference between current estimated fetal weight and previous birth weight plays an important role in assessing the risk of intrapartum cesarean delivery. Key Points Estimated fetal weight compared with previous birth weight is an important factor. Cesarean delivery is infrequent if estimated fetal weight is similar to previous birth weight. Larger estimated fetal weight greater than the previous birth weight is associated with cesarean delivery. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Belimumab use during pregnancy: a summary of birth defects and pregnancy loss from belimumab clinical trials, a pregnancy registry and postmarketing reports

Author

Petri, Michelle, primary, Landy, Helain, additional, Clowse, Megan E B, additional, Gemzoe, Kim, additional, Khamashta, Munther, additional, Kurtinecz, Milena, additional, Levy, Roger A, additional, Liu, Andrew, additional, Marino, Rebecca, additional, Meizlik, Paige, additional, Pimenta, Jeanne M, additional, Sumner, Kelsey, additional, Tilson, Hugh, additional, Connolly, Mary Beth, additional, Wurst, Keele, additional, Harris, Julia, additional, Quasny, Holly, additional, Juliao, Patricia, additional, and Roth, David A, additional

Published
2022
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19. Belimumab use during pregnancy: Interim results of the belimumab pregnancy registry

Author

Juliao, Patricia, primary, Wurst, Keele, additional, Pimenta, Jeanne M., additional, Gemzoe, Kim, additional, Landy, Helain, additional, Moody, M. Anthony, additional, Tilson, Hugh, additional, Covington, Deborah, additional, Moore, Tammy, additional, Marino, Rebecca, additional, Gilbride, Jennifer, additional, Liu, Andrew, additional, Meizlik, Paige, additional, and Petri, Michelle, additional

Published
2022
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30. Belimumab use during pregnancy: a summary of birth defects and pregnancy loss from belimumab clinical trials, a pregnancy registry and postmarketing reports.

Author

Petri, Michelle, Landy, Helain, Clowse, Megan E. B., Gemzoe, Kim, Khamashta, Munther, Kurtinecz, Milena, Levy, Roger A., Liu, Andrew, Marino, Rebecca, Meizlik, Paige, Pimenta, Jeanne M., Sumner, Kelsey, Tilson, Hugh, Connolly, Mary Beth, Wurst, Keele, Harris, Julia, Quasny, Holly, Juliao, Patricia, and Roth, David A.

Published
2023
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31. Belimumab use during pregnancy: Interim results of the belimumab pregnancy registry.

Author

Juliao, Patricia, Wurst, Keele, Pimenta, Jeanne M., Gemzoe, Kim, Landy, Helain, Moody, M. Anthony, Tilson, Hugh, Covington, Deborah, Moore, Tammy, Marino, Rebecca, Gilbride, Jennifer, Liu, Andrew, Meizlik, Paige, and Petri, Michelle

Abstract

Background: Belimumab is approved for active, autoantibody‐positive systemic lupus erythematosus (SLE) and lupus nephritis, but limited data exist regarding its use in pregnancy. The Belimumab Pregnancy Registry (BPR, GSK Study BEL114256; NCT01532310) was created to evaluate pregnancy and infant outcomes following belimumab exposure. Methods: Individuals with SLE exposed to belimumab from 4 months before and/or during pregnancy can enroll into the BPR. The primary outcome is major birth defects; secondary outcomes include miscarriages, stillbirths, elective termination, pre‐term birth, neonatal death, small for gestational age, and adverse infant outcomes during the first year of life. Belimumab exposure timing, concomitant medications, and other potential confounding factors are also collected. Data up to March 8, 2021, are reported descriptively. Results: From an expected sample size target of 500 prospective pregnancies with a known outcome, only 55 were enrolled in the study. Among these, two pregnancy losses and 53 pregnancies with a live birth outcome were reported. Ten of the 53 live birth pregnancies resulted in a major birth defect. Ten pregnancies were enrolled after the pregnancy outcome occurred and were examined retrospectively (four live births with no defects, four miscarriages, and two elective terminations). There was no indication or pattern of birth defects associated with belimumab. Conclusions: Low recruitment numbers for the BPR and incomplete information limit the conclusions regarding belimumab exposure during pregnancy. There was no pattern or common mechanism of birth defects associated with belimumab within the BPR data. [ABSTRACT FROM AUTHOR]

Published
2023
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38. Contemporary cesarean delivery practice in the United States

Author

Zhang, Jun, Troendle, James, Reddy, Uma M., Laughon, Katherine S., Branch, Ware D., Burkman, Ronald, Landy, Helain J., Hibbard, Judith U., Haberman, Shoshana, Ramirez, Mildred M., Bailit, Jennifer L., Hoffman, Matthew K., Gregory, Kimberly D., Gonzalez-Quintero, Victor H., Kominiarek, Michelle, Learman, Lee A., Hatjis, Christos G., and van Veldhuisen, Paul

Published
2010

39. The maternal body mass index: a strong association with delivery route

Author

Kominiarek, Michelle A., VanVeldhuisen, Paul, Hibbard, Judith, Landy, Helain, Haberman, Shoshana, Learman, Lee, Wilkins, Isabelle, Bailit, Jennifer, Branch, Ware, Burkman, Ronald, Gonzalez-Quintero, Victor Hugo, Gregory, Kimberly, Hatjis, Christos, Hoffman, Matthew, Ramirez, Mildred, Reddy, Uma M., Troendle, James, and Zhang, Jun

Published
2010

40. Maternal and neonatal outcomes by labor onset type and gestational age

Author

Bailit, Jennifer L., Gregory, Kimberly D., Reddy, Uma M., Gonzalez-Quintero, Victor H., Hibbard, Judith U., Ramirez, Mildred M., Branch, Ware D., Burkman, Ronald, Haberman, Shoshana, Hatjis, Christos G., Hoffman, Matthew K., Kominiarek, Michelle, Landy, Helain J., Learman, Lee A., Troendle, James, Van Veldhuisen, Paul, Wilkins, Isabelle, Sun, Liping, and Zhang, Jun

Published
2010

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