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509 results on '"Landry, Donald W."'

3. MECHANISMS IN ENDOCRINOLOGY: Vitamin D and COVID-19

Author

Bilezikian, John P, Bikle, Daniel, Hewison, Martin, Lazaretti-Castro, Marise, Formenti, Anna Maria, Gupta, Aakriti, Madhavan, Mahesh V, Nair, Nandini, Babalyan, Varta, Hutchings, Nicholas, Napoli, Nicola, Accili, Domenico, Binkley, Neil, Landry, Donald W, and Giustina, Andrea

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Clinical Sciences, Biodefense, Lung, Vaccine Related, Emerging Infectious Diseases, Nutrition, Infectious Diseases, Prevention, Good Health and Well Being, Adaptive Immunity, Antimicrobial Cationic Peptides, Autophagy, Betacoronavirus, COVID-19, Coronavirus Infections, Cytokine Release Syndrome, Defensins, Humans, Immunity, Innate, Immunocompetence, Pandemics, Pneumonia, Viral, SARS-CoV-2, T-Lymphocytes, T-Lymphocytes, Regulatory, Th1 Cells, Th17 Cells, Th2 Cells, Vitamin D, Cathelicidins, Paediatrics and Reproductive Medicine, Endocrinology & Metabolism, Clinical sciences, Reproductive medicine
Abstract

The SARS-CoV-2 virus responsible for the COVID-19 pandemic has generated an explosion of interest both in the mechanisms of infection leading to dissemination and expression of this disease, and in potential risk factors that may have a mechanistic basis for disease propagation or control. Vitamin D has emerged as a factor that may be involved in these two areas. The focus of this article is to apply our current understanding of vitamin D as a facilitator of immunocompetence both with regard to innate and adaptive immunity and to consider how this may relate to COVID-19 disease. There are also intriguing potential links to vitamin D as a factor in the cytokine storm that portends some of the most serious consequences of SARS-CoV-2 infection, such as the acute respiratory distress syndrome. Moreover, cardiac and coagulopathic features of COVID-19 disease deserve attention as they may also be related to vitamin D. Finally, we review the current clinical data associating vitamin D with SARS-CoV-2 infection, a putative clinical link that at this time must still be considered hypothetical.

Published
2020

8. Silencing c-Myc translation as a therapeutic strategy through targeting PI3Kδ and CK1ε in hematological malignancies

Author

Deng, Changchun, Lipstein, Mark R, Scotto, Luigi, Jirau Serrano, Xavier O, Mangone, Michael A, Li, Shirong, Vendome, Jeremie, Hao, Yun, Xu, Xiaoming, Deng, Shi-Xian, Realubit, Ronald B, Tatonetti, Nicholas P, Karan, Charles, Lentzsch, Suzanne, Fruman, David A, Honig, Barry, Landry, Donald W, and O'Connor, Owen A

Subjects
Genetics, Hematology, Cancer, Orphan Drug, Lymphoma, Rare Diseases, Biotechnology, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Animals, Antineoplastic Agents, Casein Kinase 1 epsilon, Cell Line, Tumor, Drug Synergism, Hematologic Neoplasms, Humans, Mice, Oligopeptides, Phosphoinositide-3 Kinase Inhibitors, Protein Biosynthesis, Protein Kinase Inhibitors, Proto-Oncogene Proteins c-myc, Random Allocation, Xenograft Model Antitumor Assays, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Paediatrics and Reproductive Medicine, Immunology
Abstract

Phosphoinositide 3-kinase (PI3K) and the proteasome pathway are both involved in activating the mechanistic target of rapamycin (mTOR). Because mTOR signaling is required for initiation of messenger RNA translation, we hypothesized that cotargeting the PI3K and proteasome pathways might synergistically inhibit translation of c-Myc. We found that a novel PI3K δ isoform inhibitor TGR-1202, but not the approved PI3Kδ inhibitor idelalisib, was highly synergistic with the proteasome inhibitor carfilzomib in lymphoma, leukemia, and myeloma cell lines and primary lymphoma and leukemia cells. TGR-1202 and carfilzomib (TC) synergistically inhibited phosphorylation of the eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1), leading to suppression of c-Myc translation and silencing of c-Myc-dependent transcription. The synergistic cytotoxicity of TC was rescued by overexpression of eIF4E or c-Myc. TGR-1202, but not other PI3Kδ inhibitors, inhibited casein kinase-1 ε (CK1ε). Targeting CK1ε using a selective chemical inhibitor or short hairpin RNA complements the effects of idelalisib, as a single agent or in combination with carfilzomib, in repressing phosphorylation of 4E-BP1 and the protein level of c-Myc. These results suggest that TGR-1202 is a dual PI3Kδ/CK1ε inhibitor, which may in part explain the clinical activity of TGR-1202 in aggressive lymphoma not found with idelalisib. Targeting CK1ε should become an integral part of therapeutic strategies targeting translation of oncogenes such as c-Myc.

Published
2017

9. Post-acute COVID-19 syndrome

Author

Nalbandian, Ani, Sehgal, Kartik, Gupta, Aakriti, Madhavan, Mahesh V., McGroder, Claire, Stevens, Jacob S., Cook, Joshua R., Nordvig, Anna S., Shalev, Daniel, Sehrawat, Tejasav S., Ahluwalia, Neha, Bikdeli, Behnood, Dietz, Donald, Der-Nigoghossian, Caroline, Liyanage-Don, Nadia, Rosner, Gregg F., Bernstein, Elana J., Mohan, Sumit, Beckley, Akinpelumi A., Seres, David S., Choueiri, Toni K., Uriel, Nir, Ausiello, John C., Accili, Domenico, Freedberg, Daniel E., Baldwin, Matthew, Schwartz, Allan, Brodie, Daniel, Garcia, Christine Kim, Elkind, Mitchell S. V., Connors, Jean M., Bilezikian, John P., Landry, Donald W., and Wan, Elaine Y.

Published
2021
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11. Extrapulmonary manifestations of COVID-19

Author

Gupta, Aakriti, Madhavan, Mahesh V., Sehgal, Kartik, Nair, Nandini, Mahajan, Shiwani, Sehrawat, Tejasav S., Bikdeli, Behnood, Ahluwalia, Neha, Ausiello, John C., Wan, Elaine Y., Freedberg, Daniel E., Kirtane, Ajay J., Parikh, Sahil A., Maurer, Mathew S., Nordvig, Anna S., Accili, Domenico, Bathon, Joan M., Mohan, Sumit, Bauer, Kenneth A., Leon, Martin B., Krumholz, Harlan M., Uriel, Nir, Mehra, Mandeep R., Elkind, Mitchell S. V., Stone, Gregg W., Schwartz, Allan, Ho, David D., Bilezikian, John P., and Landry, Donald W.

Published
2020
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12. Exploring the Landscape of Aptamers: From Cross-Reactive to Selective to Specific, High-Affinity Receptors for Cocaine

Author

Yang, Kyungae, primary, Alkhamis, Obtin, additional, Canoura, Juan, additional, Bryant, Alexandra, additional, Gong, Edward M., additional, Barbu, Mihaela, additional, Taylor, Steven, additional, Nikic, Dragan, additional, Banerjee, Saswata, additional, Xiao, Yi, additional, Stojanovic, Milan N., additional, and Landry, Donald W., additional

Published
2024
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13. A pharmacological toolkit for human microglia identifies Topoisomerase I inhibitors as immunomodulators for Alzheimer’s disease

Author

Haage, Verena, primary, Tuddenham, John F., additional, Comandante-Lou, Natacha, additional, Bautista, Alex, additional, Monzel, Anna, additional, Chiu, Rebecca, additional, Fujita, Masashi, additional, Garcia, Frankie G., additional, Bhattarai, Prabesh, additional, Patel, Ronak, additional, Buonfiglioli, Alice, additional, Idiarte, Juan, additional, Herman, Mathieu, additional, Rinderspacher, Alison, additional, Mela, Angeliki, additional, Zhao, Wenting, additional, Argenziano, Michael G., additional, Furnari, Julia L., additional, Banu, Matei A., additional, Landry, Donald W., additional, Bruce, Jeffrey N., additional, Canoll, Peter, additional, Zhang, Ya, additional, Nuriel, Tal, additional, Kizil, Caghan, additional, Sproul, Andrew A., additional, de Witte, Lotje D., additional, Sims, Peter A., additional, Menon, Vilas, additional, Picard, Martin, additional, and De Jager, Philip L., additional

Published
2024
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14. A Pharmacological Toolkit for Human Microglia Identifies Topoisomerase I Inhibitors as Immunomodulators for Alzheimer's Disease

Author

Haage, Verena Claudia, primary, Tuddenham, John F., additional, Comandante-Lou, Natacha, additional, Bautista, Alex, additional, Monzel, Anna, additional, Chiu, Rebecca, additional, Fujita, Masashi, additional, Garcia, Frankie G., additional, Bhattarai, Prabesh, additional, Patel, Ronak, additional, Buonfiglioli, Alice, additional, Idiarte, Juan, additional, Herman, Mathieu, additional, Rinderspacher, Alison, additional, Mela, Angeliki, additional, Zhao, Wenting, additional, Argenziano, Michael, additional, Furnari, Julia L., additional, Banu, Matei A., additional, Landry, Donald W., additional, Bruce, Jeffrey N., additional, Canoll, Peter, additional, Zhang, Ya, additional, Nuriel, Tal, additional, Kizil, Caghan, additional, Sproul, Andrew, additional, de Witte, Lot D., additional, Sims, Peter A., additional, Menon, Vilas, additional, Picard, Martin, additional, and De Jager, Philip L., additional

Published
2024
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17. Prioritizing clinical research studies during the COVID-19 pandemic: lessons from New York City

Author

Gulick, Roy M., Sobieszczyk, Magdalena E., Landry, Donald W., and Hollenberg, Anthony N.

Subjects
Clinical trials -- Health aspects, Sarilumab -- Health aspects, Hospital patients -- Health aspects, Coronaviruses -- Health aspects, Epidemics -- New York -- China, Ventilators (Medical equipment) -- Health aspects, Medical research -- Health aspects, COVID-19 -- Health aspects, Health care industry
Abstract

Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, was first recognized in Wuhan, China in December 2019 (1) and rapidly spread through Asia and Europe, with the first US case identified [...]

Published
2020
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20. A functional group–guided approach to aptamers for small molecules

Author

Yang, Kyungae, primary, Mitchell, Noelle M., additional, Banerjee, Saswata, additional, Cheng, Zhenzhuang, additional, Taylor, Steven, additional, Kostic, Aleksandra M., additional, Wong, Isabel, additional, Sajjath, Sairaj, additional, Zhang, Yameng, additional, Stevens, Jacob, additional, Mohan, Sumit, additional, Landry, Donald W., additional, Worgall, Tilla S., additional, Andrews, Anne M., additional, and Stojanovic, Milan N., additional

Published
2023
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23. Colaboradores

Author

Abrams, Charles S., Adler, Ronald S., Agarwal, Anupam, Akin, Cem, Aksamit, Allen J., Jr., Al-Awqati, Qais, Allen, Upton D., Allos, Ban Mishu, Angus, Derek C., Appelbaum, Frederick R., Armitage, James O., Armstrong, April W., Armstrong, Deborah K., Arnaout, M. Amin, Arnold, Robert M., Aronson, Louise, Atkinson, John P., Attia, Evelyn, Auerbach, Andrew D., Ayanian, John Z., Baddour, Larry M., Baden, Lindsey R., Bailey, Thomas C., Bain, Barbara J., Bajorin, Dean F., Baloh, Robert W., Bangham, Charles R.M., Barasch, Jonathan, Barrett, Bruce, Bartholomew, John R., Bartleson, J.D., Barton, Mary B., Basner, Robert C., Bass, Adam J., Bass, Anne R., Bauman, Julie E., Bausch, Daniel G., Bayer, Arnold S., Bazarian, Jeffrey J., Bearman, Gonzalo M., Becker, Richard C., Beckham, J. David, Beckman, Joshua A., Beigel, John H., Bel, Elisabeth H., Belda, Walter, Jr., Benarroch, Eduardo E., Berger, Joseph R., Berliner, Nancy, Bernat, James L., Bessesen, Daniel H., Bibbins-Domingo, Kirsten, Biesecker, Leslie G., Biundo, Joseph J., Blankson, Joel N., Bloch, Karen C., Blom, Henk J., Boden, William E., Boivin, Guy, Bolognia, Jean, Bonomo, Robert A., Booth, Sarah L., Bosaeus, Ingvar G., Brenner, David J., Bridges, S. Louis, Jr., Brochard, Laurent, Brodsky, Robert A., Brook, Itzhak, Brown, Jennifer R., Brunetti, Enrico, Bryant, Amy E., Budge, Philip J., Buffet, Pierre A., Bushinsky, David A., Bykerk, Vivian P., Calabresi, Peter A., Calello, Diane P., Calfee, David P., Callahan, S. Todd, Camilleri, Michael, Canoso, Juan J., Cappellini, Maria Domenica, Carabello, Blase A., Carucci, Laura R., Castells, Mariana, Catherino, William H., Cederholm, Tommy E., Chalasani, Naga P., Chambers, Henry F., Chang, Larry W., Chang, Lin, Chao, Nelson J., Chatterjee, Mitali, Chaturvedi, Seemant, Chen, Lin H., Chen, Sharon C-A, Chon, Susan Y., Christiani, David C., Chu, Edward, Cieslak, Theodore J., Cioffi, George A., Clancy, Carolyn M., Clauss, Heather, Clauw, Daniel J., Clemmons, David R., Coffman, Thomas M., Cohen, David, Cohen, Jeffrey, Cohen, Myron S., Cohen, Steven P., Connors, Joseph M., Cook, Deborah J., Cook, Lucy B.M., Cooney, Kathleen A., Craigen, William J., Crandall, Jill P., Croft, Simon L., Crow, Mary K., Crump, John A., Cudkowicz, Merit E., Cunningham-Rundles, Charlotte, Dahir, Kathryn M., Damon, Inger K., Daras, Michael, Dart, Richard C., Davidson, Nancy E., Deane, Kevin D., DeAngelis, Lisa M., DeCamp, Malcolm M., DeLoughery, Thomas G., del Rio, Carlos, De Luca, Gabriele C., Denning, David W., Deuster, Patricia A., DeZern, Amy E., Dhatariya, Ketan K., Diasio, Robert B., Diemert, David J., Digre, Kathleen B., Dilsizian, Vasken, Dionne, Jodie A., Di Paola, Jorge, Dispenzieri, Angela, Dogra, Sunil, Doroshow, James H., Douglas, John M., Jr., Drazen, Jeffrey M., Drekonja, Dimitri, Dubberke, Erik R., DuBeau, Catherine E., Dumler, J. Stephen, Duvic, Madeleine, Ebi, Kristie, Edwards, Kathryn M., Edwards, N. Lawrence, Eikelboom, John W., Einhorn, Lawrence H., Elliott, Perry M., Emanuel, Ezekiel J., Falagas, Matthew E., Falk, Gary W., Fang, James C., Farley, Monica M., Feder, Gene, Feller-Kopman, David J., File, Thomas McDonald, Jr., Fishman, Glenn I., Flack, John M., Fleckenstein, James M., Fleisher, Lee A., Flint, Paul W., Fogel, Evan L., Fontana, Robert J., Forsmark, Chris E., Fournier, Pierre-Edouard, Fowler, Vance G., Jr., Franco, Manuel A., Fraser, Victoria J., Freeman, Roy, Freund, Karen M., Froberg, Blake A., Gallagher, Patrick G., Gandhi, Monica, Gandhi, Rajesh T., Ganz, Leonard, Garan, Hasan, Garcia-Tsao, Guadalupe, Geisler, William M., Gelfand, Joel M., George, Tony P., Gepstein, Lior, Gertz, Morie A., Ghanem, Khalil G., Gharavi, Ali G., Ghossein, Cybele, Gill, Christopher J., Ginsburg, Geoffrey S., Glesby, Marshall J., Gnann, John W., Jr., Goldman, David L., Goldman, Lee, Goldstein, Larry B., Gordon, Anthony C., Gotlib, Jason, Gotuzzo, Eduardo, Grasemann, Hartmut, Green-McKenzie, Judith, Greenberg, Harry B., Greenberg, Steven A., Greer, David M., Greysen, S. Ryan, Griffin, Marie R., Griggs, Robert C., Grossman, Daniel, Guay-Woodford, Lisa M., Gulick, Roy M., Haake, David A., Hagman, Melissa M., Hagspiel, Klaus D., Harris, Raymond C., Havers, Fiona P., Heath, Elisabeth I., Hecht, Frederick M., Hensrud, Donald D., Hess, Jeremy, Hewlett, Erik L., Hift, Richard J., Hill, David R., Hill, Nicholas S., Hillyer, Christopher D., Hirsch, Hans H., Hoeper, Marius M., Hoit, Brian D., Holers, V. Michael, Holland, Steven M., Hollenberg, Anthony N., Hollenberg, Steven M., Howard, Jo, Hunter, David J., Hussain, Khalid, Iannuzzi, Michael C., Inman, Robert D., Inouye, Sharon K., Ison, Michael G., Jen, Joanna C., Jensen, Dennis M., Jensen, Michael D., Jensen, Robert T., Johnston, S. Claiborne, Jones, Robin L., Jordan, Richard C., Kahi, Charles J., Kaiser, Laurent, Kaminski, Henry J., Kamya, Moses R., Kao, Louise W., Kaplan, Steven A., Kastner, Daniel L., Katzka, David A., Katzman, Debra K., Kaushansky, Kenneth, Kaye, Keith S., Keating, Armand, Kelley, Robin K., Kennedy, Richard B., Khuri, Fadlo R., Kim, Rose, Kirchhoff, Louis V., Kirking, Hannah, Kirtane, Ajay J., Kishnani, Priya S., Klausner, Jeffrey D., Klion, Amy D., Klompas, Michael, Knopman, David S., Ko, Christine J., Kodali, Susheel, Kontoyiannis, Dimitrios P., Koppel, Barbara S., Korenblat, Kevin M., Korf, Bruce R., Kortepeter, Mark G., Koshy, Anita A., Kottilil, Shyamasundaran, Kovacs, Joseph A., Kovacs, Thomas O., Kowdley, Kris V., Kraft, Monica, Kramer, Christopher M., Krasnewich, Donna M., Kraus, William E., Krause, Peter J., Kroger, Andrew T., Kroshinsky, Daniela, Kuemmerle, John F., Kuipers, Ernst J., Kutner, Jean S., Laheru, Daniel, Lampert, Rachel, Landefeld, C. Seth, Landovitz, Raphael J., Landry, Donald W., Lange, Richard A., Lee, Hochang B., Lee, Nelson, Levey, Andrew S., Levine, Stephanie M., Lichtenstein, Gary R., Liebmann, Jeffrey M., Liebschutz, Jane M., Lim, Henry W., Lima, Aldo A.M., Limaye, Ajit P., Limdi, Nita A., Link, Mark S., Liu, Catherine, Lloyd-Jones, Donald M., Lopez, Fred A., Louie, Arnold, Lyness, Jeffrey M., MacKenzie, C. Ronald, MacLennan, Calman A., MacMillan, Harriet L., Madoff, Robert D., Maher, Jacquelyn, Maier, Lisa A., Maldarelli, Frank, Malhotra, Atul, Manary, Mark J., Marcos, Luis A., Marelli, Ariane J., Marks, Andrew R., Marschall, Jonas, Martin, Paul, Martinez, Fernando J., Mason, Joel B., Masur, Henry, Mathers, Amy J., Matthay, Michael A., McCool, F. Dennis, McInnes, Iain B., McLaughlin, Vallerie, McMichael, Amy, McMurray, John J.V., McQuaid, Kenneth R., Mead, Paul S., Means, Robert T., Jr., Melia, Michael T., Mellinghoff, Ingo K., Melton, Genevieve B., Merrick, Samuel T., Miceli, Marisa H., Michel, Marc, Mokdad, Ali H., Moy, Ernest, Mukherjee, Debabrata, Murr, Andrew H., Myerburg, Robert J., Nadeau, Kari C., Nath, Avindra, Neal-Perry, Genevieve, Neilson, Eric G., Nelson, Christina A., Nelson, David B., Nelson, Lewis S., Nestler, Eric J., Neuzil, Kathleen M., Nieman, Lynnette K., Niven, Alexander S., O’Connor, Christopher M., O’Connor, Francis G., O’Connor, Patrick G., O’Donnell, Anne E., O’Donnell, James S., Oh, Jae K., Okun, Michael S., O’Leary, Sean T., Olgin, Jeffrey E., Olivier, Kenneth N., Olivotto, Iacopo, Olsen, Nancy J., Orenstein, Walter A., Ortel, Thomas L., O’Shea, John J., Osmon, Douglas R., Ostrem, Jill L., Ostrosky-Zeichner, Luis, Otto, Catherine M., Ottolini, Martin G., Ovsyannikova, Inna G., Pappas, Peter G., Park, Ben Ho, Patel, Robin, Patterson, Thomas F., Pawlotsky, Jean-Michel, Payne, Thomas H., Pearce, Elizabeth N., Pearson, Richard D., Perl, Trish M., Petersen, Brett W., Petri, William A., Jr., Pfeffer, Marc A., Philips, Jennifer A., Pisetsky, David S., Pletcher, Steven D., Plumb, Ian D., Poland, Gregory A., Powell, Frank, Pyeritz, Reed E., Quinn, Thomas C., Racaniello, Vincent, Radhakrishnan, Jai, Radich, Jerald, Rafailidis, Petros I., Raghu, Ganesh, Ragni, Margaret V., Rahman, Proton, Rajkumar, S. Vincent, Ralston, Stuart H., Raoult, Didier, Reboli, Annette C., Reddy, K. Rajender, Redelmeier, Donald A., Redlich, Carrie A., Reilly, John, Reller, Megan E., Reno, Hilary E.L., Resnick, Neil M., Rice, Louis B., Roach, E. Steve, Robinson, Jennifer G., Rogatsky, Inez, Rogers, Joseph G., Rolain, Jean-Marc, Rollins, Barrett J., Romero, José R., Rosen, Jennifer B., Rosenthal, Philip J., Russell, James A., Rustgi, Anil K., Safer, Joshua D., Saini, Sarbjit S., Salmon, Jane E., Salvana, Edsel Maurice T., Santoro, Nanette, Santucci, Peter A., Sarnak, Mark J., Savage, Kerry J., Savard, Patrice, Sawka, Michael N., Scanlon, Paul D., Schafer, Andrew I., Schiff, Manuel, Schilsky, Michael L., Schneider, Thomas Rudolf, Schooley, Robert T., Schriger, David L., Schuchter, Lynn M., Schwartz, Lawrence B., Seas, Carlos, Seifert, Steven A., Seifter, Julian Lawrence, Selcen, Duygu, Selim, Magdy, Semrad, Carol E., Sepulveda, Jorge, Shaw, Pamela J., Shaz, Beth H., Sheridan, Robert L., Sherman, Stuart, Shojania, Kaveh G., Shopsin, Bo, Shy, Michael E., Sidransky, Ellen, Sifri, Costi D., Siliciano, Robert F., Simel, David L., Skorecki, Karl, Slawski, Barbara A., Slutsky, Arthur S., Smetana, Gerald W., Smith, A. Gordon, Smith, Stephen R., Southwick, Frederick S., Spiegel, Allen M., Spiera, Robert, Spinola, Stanley M., Spong, Catherine Y., Stabler, Sally P., Stark, Paul, Clair, E. William St., Steiner, Theodore S., Stephens, David S., Stevens, David A., Stevens, Dennis L., Stokes, M. Barry, Stoller, James K., Stone, John H., Stone, Richard M., Su, Edwin P., Swerdloff, Ronald S., Swygard, Heidi, Sykes, Megan, Talbot, H. Keipp, Tamimi, Rulla M., Tanofsky-Kraff, Marian, Tarlo, Susan M., Taylor, Stephanie N., Teirstein, Paul S., Telford, Sam R., III, Thakker, Rajesh V., Therrien, Judith, Thompson, George R., III, Tormoehlen, Laura, Tosti, Antonella, Trehan, Indi, Umpierrez, Guillermo E., Valeri, Anthony Michael, Varga, John, Vaughn, Bradley V., Venook, Alan P., Verbalis, Joseph G., Vose, Julie M., Wachter, Robert M., Walsh, B. Timothy, Walsh, Edward E., Walsh, Thomas J., Walston, Jeremy D., Walter, Roland B., Wang, Christina, Wang, Kenneth K., Ware, Lorraine B., Warren, Cirle A., Watkins, Paul B., Weber, Thomas J., Weimer, Louis H., Weinberg, Geoffrey A., Weinstein, Robert S., Weiss, Roger D., Weiss, Roy E., Weitz, Jeffrey I., Welt, Frederick G.P., Wenzel, Richard P., Werth, Victoria P., West, Sterling G., White, A. Clinton, Jr., White, Christopher J., White, Julian, White, Perrin C., Whitley, Richard J., Whyte, Michael P., Wiebe, Samuel, Wiener-Kronish, Jeanine P., Wilber, David J., Wilcox, Mark H., Winikoff, Beverly, Winter, Jane N., Wittink, Marsha N., Wolff, Tracy A., Wolin, Edward M., Wormser, Gary P., Yancy, Clyde W., Young, Neal S., Young, Vincent B., Young, William F., Jr., Yu, Alan S.L., Zimetbaum, Peter, and Zucker, Jane R.

Published
2025
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26. Contributors

Author

Agarwal, Rachit, primary, Ahlstrom, Jon D., additional, Ahmad, Rafiq, additional, Alarcon, Emilio I., additional, Almarza, Alejandro J., additional, Almeida-Porada, Graça, additional, Almeida, Manuel, additional, Alvarado-Velez, Melissa, additional, Anderson, James M., additional, Arcidiacono, Judith, additional, Atala, Anthony, additional, Badylak, Stephen F., additional, Balkan, Wayne, additional, Ballios, Brian G., additional, Baptista, Pedro M., additional, Baumann, M. Douglas, additional, Bedi, Supinder S., additional, Bellamkonda, Ravi V., additional, Bergmann, Nicole M., additional, Blau, Helen M., additional, Boerckel, Joel D., additional, Bratt-Leal, Andres M., additional, Brown, James C., additional, Brubaker, Scott, additional, Brunette, Isabelle, additional, Calderon, Gisele A., additional, Caplan, Arnold I., additional, Castner, David G., additional, Chang, Cynthia, additional, Chawla, Aditya, additional, Chen, Xuguang, additional, Cohen, Paul, additional, Cooke, Michael J., additional, Copus, Joshua S., additional, Correlo, Vitor M., additional, Cox, Charles S., additional, Dahl, Abritee, additional, Day, Richard M., additional, De Coppi, Paolo, additional, Dodla, Mahesh C., additional, Elisseeff, Jennifer H., additional, Emamaullee, Juliet A., additional, Esa, Adam, additional, Fang, Yunlan, additional, Faust, Heather J., additional, Fisher, John P., additional, Fisher, Matthew B., additional, Francois, Elvis L., additional, García, Andrés J., additional, Gavrilov, Svetlana, additional, Gazit, Dan, additional, Gazit, Zulma, additional, Gemmiti, Christopher V., additional, Gillispie, Gregory J., additional, Gilpin, Sarah E., additional, Godbey, W.T., additional, Gray, Andrea, additional, Green, Ronald M., additional, Griffith, May, additional, Guldberg, Robert E., additional, Guo, Qiongyu, additional, Gurtner, Geoffrey C., additional, Hacker, Michael C., additional, Hanna, Issa A., additional, Hare, Joshua M., additional, Hatzistergos, Konstantinos E., additional, Herber, Ralf-Peter, additional, Hilborn, Jöns, additional, Humes, H. David, additional, Hunsberger, Joshua G., additional, Iwasa, Kenjiro, additional, Jackson, John D., additional, Jackson, Margaret L., additional, Jang, Hae Lin, additional, Jansen, John A., additional, Johnston, Josephine, additional, Jorns, Carl, additional, Kang, Huijun, additional, Kaplan, David L., additional, Kaplan, David S., additional, Katz, Adam J., additional, Kelley, Matthew W., additional, Kennedy, Kelsey, additional, Khademhosseini, Ali, additional, Khang, Gilson, additional, Kim, Jinho, additional, Klein, Rachel H., additional, Klimanskaya, Irina, additional, Knoepfler, Paul S., additional, Ko, In Kap, additional, Kolambkar, Yash M., additional, Krieghoff, Jan, additional, Kucko, Nathan W., additional, Kumar, Manoj, additional, Kurtzberg, Joanne, additional, Kwilas, Anna, additional, Landry, Donald W., additional, Langhans, Mark T., additional, Lanza, Robert, additional, Lanzoni, Giacomo, additional, Lee, Sang Jin, additional, Leeuwenburgh, Sander C.G., additional, Leong, Kam W., additional, Liang, Rui, additional, Liaudanskaya, Volha, additional, Lin, Hang, additional, Longaker, Michael T., additional, Lorenz, Hermann P., additional, Loring, Jeanne F., additional, Lu, Shi-Jiang, additional, Lue, Alberto, additional, Ma, Peter X., additional, Magalhaes, Renata S., additional, Mandla, Serena, additional, Marshall, Clement D., additional, Martins-Green, Manuela, additional, Mason, Devon E., additional, Mau, Jonquil R., additional, McFarland, Richard, additional, McHale, Melissa K., additional, Melville, James C., additional, Meyers, Jason R., additional, Mikos, Antonios G., additional, Miller, Jordan S., additional, Mittermiller, Paul A., additional, Miyachi, Hideki, additional, Miyamoto, Shinka, additional, Monteiro, Nelson, additional, Moore, Alessandra L., additional, Morini, Sara, additional, Moser, Philipp T., additional, Mukhatyar, Vivek J., additional, Murdock, Mark, additional, Nagiel, Aaron, additional, Naughton, Gail K., additional, Nauta, Allison, additional, Navarro, Javier, additional, Newton, Jared M., additional, Nori, Aparna, additional, Okano, Teruo, additional, Oliveira, Joaquim M., additional, Ott, Harald C., additional, Padmanabhan, Jagannath, additional, Page, Kristin M., additional, Pallickaveedu Rajan Asari, Anil Kumar, additional, Papaioannou, Virginia E., additional, Park, Jihoon, additional, Payne, Samantha L., additional, Pelled, Gadi, additional, Pepper, Andrew, additional, Perumal, Elumalai, additional, Petreaca, Melissa, additional, Pino, Christopher J., additional, Pirosa, Alessandro, additional, Pla-Palacín, Iris, additional, Pokrywczynska, Marta, additional, Porada, Christopher D., additional, Porter, Blaise D., additional, Radisic, Milica, additional, Rambhia, Kunal J., additional, Raquel Maia, F., additional, Ratner, Buddy D., additional, Reddi, A.H., additional, Reis, Rui L., additional, Ricles, Laura, additional, Ricordi, Camillo, additional, Rizwan, Muhammad, additional, Robinson, Rebecca, additional, Rodrigues, Melanie, additional, Rothrauff, Benjamin B., additional, Sadri-Ardekani, Hooman, additional, Sainz-Arnal, Pilar, additional, Sambathkumar, Rangarajan, additional, Sánchez-Romero, Natalia, additional, Scarritt, Michelle, additional, Schneider, Christopher M., additional, Schwartz, Steven D., additional, Selem, Sarah, additional, Serrano-Aulló, Trinidad, additional, Shapiro, A.M. James, additional, Sheyn, Dmitriy, additional, Shimizu, Tatsuya, additional, Shinoka, Toshiharu, additional, Shoichet, Molly S., additional, Shoji, Toshihiro, additional, Shupe, Thomas, additional, Sikora, Andrew G., additional, Simpson, Fiona, additional, Skardal, Aleksander, additional, Skuk, Daniel, additional, Smith, Brandon T., additional, Sohn, Jihee, additional, Soker, Shay, additional, Solanas, Estela, additional, Song, Jeong Eun, additional, Sood, Disha, additional, Stocum, David L., additional, Strom, Stephen C., additional, Sun, Jessica M., additional, Takahashi, Hironobu, additional, Tremblay, Jacques P., additional, Tripathy, Nirmalya, additional, Tse, John W., additional, Tuan, Rocky S., additional, Verfaillie, Catherine M., additional, Vunjak-Novakovic, Gordana, additional, Wagner, William R., additional, Wang, Yanling, additional, Watson, Emma, additional, West, Jennifer L., additional, Williams, David F., additional, Williams, James K., additional, Wong, Mark E., additional, Woo, Savio L-Y., additional, Wood, Fiona M., additional, Xu, Lei, additional, Yakubovich, Doron C., additional, Yang, Yafeng, additional, Yaszemski, Michael J., additional, Yelick, Pamela C., additional, Yim, Evelyn K.F., additional, Yong, Carolyn, additional, Yoo, James J., additional, Young, Simon, additional, Yucel, Nora, additional, Zacharias, Rachel L., additional, Zhang, Yuanyuan, additional, Zhang, Ai, additional, Zhang, Jin, additional, and Zhu, Yang, additional

Published
2018
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35. Contributors

Author

Abrams, Charles S., Adler, Ronald S., Agarwal, Anupam, Akin, Cem, Aksamit, Allen J., Jr., Al-Awqati, Qais, Allen, Upton D., Allos, Ban Mishu, Angus, Derek C., Appelbaum, Frederick R., Armitage, James O., Armstrong, April W., Armstrong, Deborah K., Arnaout, M. Amin, Arnold, Robert M., Aronson, Louise, Atkinson, John P., Attia, Evelyn, Auerbach, Andrew D., Ayanian, John Z., Baddour, Larry M., Baden, Lindsey R., Bailey, Thomas C., Bain, Barbara J., Bajorin, Dean F., Baloh, Robert W., Bangham, Charles R.M., Barasch, Jonathan, Barrett, Bruce, Bartholomew, John R., Bartleson, J.D., Barton, Mary B., Basner, Robert C., Bass, Adam J., Bass, Anne R., Bauman, Julie E., Bausch, Daniel G., Bayer, Arnold S., Bazarian, Jeffrey J., Bearman, Gonzalo M., Becker, Richard C., Beckham, J. David, Beckman, Joshua A., Beigel, John H., Bel, Elisabeth H., Belda, Walter, Jr., Benarroch, Eduardo E., Berger, Joseph R., Berliner, Nancy, Bernat, James L., Bessesen, Daniel H., Bibbins-Domingo, Kirsten, Biesecker, Leslie G., Biundo, Joseph J., Blankson, Joel N., Bloch, Karen C., Blom, Henk J., Boden, William E., Boivin, Guy, Bolognia, Jean, Bonomo, Robert A., Booth, Sarah L., Bosaeus, Ingvar G., Brenner, David J., Bridges, S. Louis, Jr., Brochard, Laurent, Brodsky, Robert A., Brook, Itzhak, Brown, Jennifer R., Brunetti, Enrico, Bryant, Amy E., Budge, Philip J., Buffet, Pierre A., Bushinsky, David A., Bykerk, Vivian P., Calabresi, Peter A., Calello, Diane P., Calfee, David P., Callahan, S. Todd, Camilleri, Michael, Canoso, Juan J., Cappellini, Maria Domenica, Carabello, Blase A., Carucci, Laura R., Castells, Mariana, Catherino, William H., Cederholm, Tommy E., Chalasani, Naga P., Chambers, Henry F., Chang, Larry W., Chang, Lin, Chao, Nelson J., Chatterjee, Mitali, Chaturvedi, Seemant, Chen, Lin H., C-A Chen, Sharon, Chon, Susan Y., Christiani, David C., Chu, Edward, Cieslak, Theodore J., Cioffi, George A., Clancy, Carolyn M., Clauss, Heather, Clauw, Daniel J., Clemmons, David R., Coffman, Thomas M., Cohen, David, Cohen, Jeffrey, Cohen, Myron S., Cohen, Steven P., Connors, Joseph M., Cook, Deborah J., Cook, Lucy B.M., Cooney, Kathleen A., Craigen, William J., Crandall, Jill P., Croft, Simon L., Crow, Mary K., Crump, John A., Cudkowicz, Merit E., Cunningham-Rundles, Charlotte, Dahir, Kathryn M., Damon, Inger K., Daras, Michael, Dart, Richard C., Davidson, Nancy E., Deane, Kevin D., DeAngelis, Lisa M., DeCamp, Malcolm M., DeLoughery, Thomas G., Rio, Carlos del, De Luca, Gabriele C., Denning, David W., Deuster, Patricia A., DeZern, Amy E., Dhatariya, Ketan K., Diasio, Robert B., Diemert, David J., Digre, Kathleen B., Dilsizian, Vasken, Dionne, Jodie A., Di Paola, Jorge, Dispenzieri, Angela, Dogra, Sunil, Doroshow, James H., Douglas, John M., Jr., Drazen, Jeffrey M., Drekonja, Dimitri, Dubberke, Erik R., DuBeau, Catherine E., Dumler, J. Stephen, Duvic, Madeleine, Ebi, Kristie, Edwards, Kathryn M., Edwards, N. Lawrence, Eikelboom, John W., Einhorn, Lawrence H., Elliott, Perry M., Emanuel, Ezekiel J., Falagas, Matthew E., Falk, Gary W., Fang, James C., Farley, Monica M., Feder, Gene, Feller-Kopman, David J., McDonald File, Thomas, Jr., Fishman, Glenn I., Flack, John M., Fleckenstein, James M., Fleisher, Lee A., Flint, Paul W., Fogel, Evan L., Fontana, Robert J., Forsmark, Chris E., Fournier, Pierre-Edouard, Fowler, Vance G., Jr., Franco, Manuel A., Fraser, Victoria J., Freeman, Roy, Freund, Karen M., Froberg, Blake A., Gallagher, Patrick G., Gandhi, Monica, Gandhi, Rajesh T., Ganz, Leonard, Garan, Hasan, Garcia-Tsao, Guadalupe, Geisler, William M., Gelfand, Joel M., George, Tony P., Gepstein, Lior, Gertz, Morie A., Ghanem, Khalil G., Gharavi, Ali G., Ghossein, Cybele, Gill, Christopher J., Ginsburg, Geoffrey S., Glesby, Marshall J., Gnann, John W., Jr., Goldman, David L., Goldman, Lee, Goldstein, Larry B., Gordon, Anthony C., Gotlib, Jason, Gotuzzo, Eduardo, Grasemann, Hartmut, Green-McKenzie, Judith, Greenberg, Harry B., Greenberg, Steven A., Greer, David M., Greysen, S. Ryan, Griffin, Marie R., Griggs, Robert C., Grossman, Daniel, Guay-Woodford, Lisa M., Gulick, Roy M., Haake, David A., Hagman, Melissa M., Hagspiel, Klaus D., Harris, Raymond C., Havers, Fiona P., Heath, Elisabeth I., Hecht, Frederick M., Hensrud, Donald D., Hess, Jeremy, Hewlett, Erik L., Hift, Richard J., Hill, David R., Hill, Nicholas S., Hillyer, Christopher D., Hirsch, Hans H., Hoeper, Marius M., Hoit, Brian D., Holers, V. Michael, Holland, Steven M., Hollenberg, Anthony N., Hollenberg, Steven M., Howard, Jo, Hunter, David J., Hussain, Khalid, Iannuzzi, Michael C., Inman, Robert D., Inouye, Sharon K., Ison, Michael G., Jen, Joanna C., Jensen, Dennis M., Jensen, Michael D., Jensen, Robert T., Johnston, S. Claiborne, Jones, Robin L., Jordan, Richard C., Kahi, Charles J., Kaiser, Laurent, Kaminski, Henry J., Kamya, Moses R., Kao, Louise W., Kaplan, Steven A., Kastner, Daniel L., Katzka, David A., Katzman, Debra K., Kaushansky, Kenneth, Kaye, Keith S., Keating, Armand, Kelley, Robin K., Kennedy, Richard B., Khuri, Fadlo R., Kim, Rose, Kirchhoff, Louis V., Kirking, Hannah, Kirtane, Ajay J., Kishnani, Priya S., Klausner, Jeffrey D., Klion, Amy D., Klompas, Michael, Knopman, David S., Ko, Christine J., Kodali, Susheel, Kontoyiannis, Dimitrios P., Koppel, Barbara S., Korenblat, Kevin M., Korf, Bruce R., Kortepeter, Mark G., Koshy, Anita A., Kottilil, Shyamasundaran, Kovacs, Joseph A., Kovacs, Thomas O., Kowdley, Kris V., Kraft, Monica, Kramer, Christopher M., Krasnewich, Donna M., Kraus, William E., Krause, Peter J., Kroger, Andrew T., Kroshinsky, Daniela, Kuemmerle, John F., Kuipers, Ernst J., Kutner, Jean S., Laheru, Daniel, Lampert, Rachel, Landefeld, C. Seth, Landovitz, Raphael J., Landry, Donald W., Lange, Richard A., Lee, Hochang B., Lee, Nelson, Levey, Andrew S., Levine, Stephanie M., Lichtenstein, Gary R., Liebmann, Jeffrey M., Liebschutz, Jane M., Lim, Henry W., Lima, Aldo A.M., Limaye, Ajit P., Limdi, Nita A., Link, Mark S., Liu, Catherine, Lloyd-Jones, Donald M., Lopez, Fred A., Louie, Arnold, Lyness, Jeffrey M., MacKenzie, C. Ronald, MacLennan, Calman A., MacMillan, Harriet L., Madoff, Robert D., Maher, Jacquelyn, Maier, Lisa A., Maldarelli, Frank, Malhotra, Atul, Manary, Mark J., Marcos, Luis A., Marelli, Ariane J., Marks, Andrew R., Marschall, Jonas, Martin, Paul, Martinez, Fernando J., Mason, Joel B., Masur, Henry, Mathers, Amy J., Matthay, Michael A., McCool, F. Dennis, McInnes, Iain B., McLaughlin, Vallerie, McMichael, Amy, McMurray, John J.V., McQuaid, Kenneth R., Mead, Paul S., Means, Robert T., Jr., Melia, Michael T., Mellinghoff, Ingo K., Melton, Genevieve B., Merrick, Samuel T., Miceli, Marisa H., Michel, Marc, Mokdad, Ali H., Moy, Ernest, Mukherjee, Debabrata, Murr, Andrew H., Myerburg, Robert J., Nadeau, Kari C., Nath, Avindra, Neal-Perry, Genevieve, Neilson, Eric G., Nelson, Christina A., Nelson, David B., Nelson, Lewis S., Nestler, Eric J., Neuzil, Kathleen M., Nieman, Lynnette K., Niven, Alexander S., O’Connor, Christopher M., O’Connor, Francis G., O’Connor, Patrick G., O’Donnell, Anne E., O’Donnell, James S., Oh, Jae K., Okun, Michael S., O’Leary, Sean T., Olgin, Jeffrey E., Olivier, Kenneth N., Olivotto, Iacopo, Olsen, Nancy J., Orenstein, Walter A., Ortel, Thomas L., O’Shea, John J., Osmon, Douglas R., Ostrem, Jill L., Ostrosky-Zeichner, Luis, Otto, Catherine M., Ottolini, Martin G., Ovsyannikova, Inna G., Pappas, Peter G., Park, Ben Ho, Patel, Robin, Patterson, Thomas F., Pawlotsky, Jean-Michel, Payne, Thomas H., Pearce, Elizabeth N., Pearson, Richard D., Perl, Trish M., Petersen, Brett W., Petri, William A., Jr., Pfeffer, Marc A., Philips, Jennifer A., Pisetsky, David S., Pletcher, Steven D., Plumb, Ian D., Poland, Gregory A., Powell, Frank, Pyeritz, Reed E., Quinn, Thomas C., Racaniello, Vincent, Radhakrishnan, Jai, Radich, Jerald, Rafailidis, Petros I., Raghu, Ganesh, Ragni, Margaret V., Rahman, Proton, Rajkumar, S. Vincent, Ralston, Stuart H., Raoult, Didier, Reboli, Annette C., Reddy, K. Rajender, Redelmeier, Donald A., Redlich, Carrie A., Reilly, John, Reller, Megan E., Reno, Hilary E.L., Resnick, Neil M., Rice, Louis B., Roach, E. Steve, Robinson, Jennifer G., Rogatsky, Inez, Rogers, Joseph G., Rolain, Jean-Marc, Rollins, Barrett J., Romero, José R., Rosen, Jennifer B., Rosenthal, Philip J., Russell, James A., Rustgi, Anil K., Safer, Joshua D., Saini, Sarbjit S., Salmon, Jane E., Salvana, Edsel Maurice T., Santoro, Nanette, Santucci, Peter A., Sarnak, Mark J., Savage, Kerry J., Savard, Patrice, Sawka, Michael N., Scanlon, Paul D., Schafer, Andrew I., Schiff, Manuel, Schilsky, Michael L., Schneider, Thomas Rudolf, Schooley, Robert T., Schriger, David L., Schuchter, Lynn M., Schwartz, Lawrence B., Seas, Carlos, Seifert, Steven A., Seifter, Julian Lawrence, Selcen, Duygu, Selim, Magdy, Semrad, Carol E., Sepulveda, Jorge, Shaw, Pamela J., Shaz, Beth H., Sheridan, Robert L., Sherman, Stuart, Shojania, Kaveh G., Shopsin, Bo, Shy, Michael E., Sidransky, Ellen, Sifri, Costi D., Siliciano, Robert F., Simel, David L., Skorecki, Karl, Slawski, Barbara A., Slutsky, Arthur S., Smetana, Gerald W., Smith, A. Gordon, Smith, Stephen R., Southwick, Frederick S., Spiegel, Allen M., Spiera, Robert, Spinola, Stanley M., Spong, Catherine Y., Stabler, Sally P., Stark, Paul, St. Clair, E. William, Steiner, Theodore S., Stephens, David S., Stevens, David A., Stevens, Dennis L., Stokes, M. Barry, Stoller, James K., Stone, John H., Stone, Richard M., Su, Edwin P., Swerdloff, Ronald S., Swygard, Heidi, Sykes, Megan, Talbot, H. Keipp, Tamimi, Rulla M., Tanofsky-Kraff, Marian, Tarlo, Susan M., Taylor, Stephanie N., Teirstein, Paul S., Telford, Sam R., III, Thakker, Rajesh V., Therrien, Judith, Thompson, George R., III, Tormoehlen, Laura, Tosti, Antonella, Trehan, Indi, Umpierrez, Guillermo E., Valeri, Anthony Michael, Varga, John, Vaughn, Bradley V., Venook, Alan P., Verbalis, Joseph G., Vose, Julie M., Wachter, Robert M., Walsh, B. Timothy, Walsh, Edward E., Walsh, Thomas J., Walston, Jeremy D., Walter, Roland B., Wang, Christina, Wang, Kenneth K., Ware, Lorraine B., Warren, Cirle A., Watkins, Paul B., Weber, Thomas J., Weimer, Louis H., Weinberg, Geoffrey A., Weinstein, Robert S., Weiss, Roger D., Weiss, Roy E., Weitz, Jeffrey I., Welt, Frederick G.P., Wenzel, Richard P., Werth, Victoria P., West, Sterling G., White, A. Clinton, Jr., White, Christopher J., White, Julian, White, Perrin C., Whitley, Richard J., Whyte, Michael P., Wiebe, Samuel, Wiener-Kronish, Jeanine P., Wilber, David J., Wilcox, Mark H., Winikoff, Beverly, Winter, Jane N., Wittink, Marsha N., Wolff, Tracy A., Wolin, Edward M., Wormser, Gary P., Yancy, Clyde W., Young, Neal S., Young, Vincent B., Young, William F., Jr., Yu, Alan S.L., Zimetbaum, Peter, and Zucker, Jane R.

Published
2024
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41. The Ngal reporter mouse detects the response of the kidney to injury in real time

Author

Paragas, Neal, Qiu, Andong, Zhang, Qingyin, Samstein, Benjamin, Deng, Shi-Xian, Schmidt-Ott, Kai M., Viltard, Melanie, Yu, Wenqiang, Forster, Catherine S., Gong, Gangli, Liu, Yidong, Kulkarni, Ritwij, Mori, Kiyoshi, Kalandadze, Avtandil, Ratner, Adam J., Devarajan, Prasad, Landry, Donald W., D'Agati, Vivette, Lin, Chyuan-Sheng, and Barasch, Jonathan

Subjects
Genes -- Physiological aspects -- Research, Kidneys -- Injuries -- Physiological aspects -- Research, Cell receptors -- Physiological aspects -- Research, Luciferase -- Health aspects -- Genetic aspects -- Physiological aspects -- Research, Biological sciences, Health
Abstract

Many proteins have been proposed to act as surrogate markers of organ damage, yet for many candidates the essential biomarker characteristics that link the protein to the injured organ have not yet been described. We generated an Ngal reporter mouse by inserting a double-fusion reporter gene encoding luciferase-2 and mCherry (Luc2-mC) into the Ngal (Lcn2) locus. The Ngal-Luc2-mC reporter accurately recapitulated the endogenous message and illuminated injuries in vivo in real time. In the kidney, Ngal-Luc2-mC imaging showed a sensitive, rapid, dose-dependent, reversible, and organ- and cell-specific relationship with tubular stress, which correlated with the level of urinary Ngal (uNgal). Unexpectedly, specific cells of the distal nephron were the source of uNgal. Cells isolated from Ngal-Luc2-mC mice also revealed both the onset and the resolution of the injury, and the actions of NF-kB inhibitors and antibiotics during infection. Thus, imaging of Ngal-Luc2-mC mice and cells identified injurious and reparative agents that affect kidney damage., Organ damage induces the appearance of many different proteins in serum and in urine, and some of these have been proposed as surrogate measures of tissue damage. However, such a [...]

Published
2011
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42. Locations of the [beta]1 transmembrane helices in the BK potassium channel

Author

Liu, Guoxia, Zakharov, Sergey I., Yang, Lin, Wu, Roland S., Deng, Shi-Xian, Landry, Donald W., Karlin, Arthur, and Marx, Steven O.

Subjects
Potassium channels -- Properties, Cysteine -- Properties, Electrophysiology -- Research, Science and technology
Abstract

BK channels are composed of [alpha]-subunits, which form a voltage-and [Ca.sup.2+]-gated potassium channel, and of modulatory [beta]-subunits. The [beta]1-subunit is expressed in smooth muscle, where it renders the BK channel sensitive to [[[Ca.sup.2+]].sub.i] in a voltage range near the smooth-muscle resting potential and slows activation and deactivation. BK channel acts thereby as a damped feedback regulator of voltage-dependent [Ca.sup.2+] channels and of smooth muscle tone. We explored the contacts between a and [beta]1 by determining the extent of endogenous disulfide bond formation between cysteines substituted just extracellular to the two [beta]1 transmembrane (TM) helices, TM1 and TM2, and to the seven a TM helices, consisting of S1-S6, conserved in all voltage-dependent potassium channels, and the unique SO helix, which we previously concluded was partly surrounded by S1-S4. We now find that the extracellular ends of [beta]1 TM2 and [alpha]S0 are in contact and that [beta]1 TM1 is close to both S1 and S2. The extracellular ends of TM1 and TM2 are not close to S3-S6. In almost all cases, cross-linking of TM2 to S0 or of TM1 to S1 or S2 shifted the conductance-voltage curves toward more positive potentials, slowed activation, and speeded deactivation, and in general favored the closed state. TM1 and TM2 are in position to contribute, in concert with the extracellular loop and the intracellular N- and C-terminal tails of [beta]1, to the modulation of BK channel function. auxiliary subunit | cysteine substitution | disulfide cross-linking | electrophysiology | mslo1

Published
2008

43. Position and role of the BK channel [alpha] subunit S0 helix inferred from disulfide crosslinking

Author

Liu, Guoxia, Zakharov, Sergey I., Yang, Lin, Deng, Shi-Xian, Landry, Donald W., Karlin, Arthur, and Marx, Steven O.

Subjects
Cysteine -- Physiological aspects, Potassium channels -- Physiological aspects, Cell membranes -- Chemical properties, Biological sciences, Health
Abstract

The position and role of the unique N-terminal transmembrane (TM) helix, S0, in large-conductance, voltage- and calcium-activated potassium (BK) channels are undetermined. From the extents of intra-subunit, endogenous disulfide bond formation between cysteines substituted for the residues just outside the membrane domain, we infer that the extracellular flank of S0 is surrounded on three sides by the extracellular flanks of TM helices S1 and S2 and the four-residue extracellular loop between S3 and S4. Eight different double cysteine-substituted alphas, each with one cysteine in the S0 flank and one in the S3-S4 loop, were at least 90% disulfide cross-linked. Two of these alphas formed channels in which 90% cross-linking had no effect on the [V.sub.50] or on the activation and deactivation rate constants. This implies that the extracellular ends of S0, S3, and S4 are close in the resting state and move in concert during voltage sensor activation. The association of S0 with the gating charge bearing S3 and S4 could contribute to the considerably larger electrostatic energy required to activate the BK channel compared with typical voltage-gated potassium channels with six TM helices.

Published
2008

44. Contributors

Author

Addis, Russell C., primary, Ahlstrom, Jon D., additional, Amit, Michal, additional, Andrews, Peter W., additional, Axelman, Joyce, additional, Surani, M. Azim, additional, Benvenisty, Nissim, additional, Bhatia, Mickie, additional, Brivanlou, Ali H., additional, Carnwath, Joseph W., additional, Carpenter, Melissa K., additional, Chang, Howard Y., additional, Chen, Xin, additional, Cheng, Tao, additional, Chuva de Sousa Lopes, Susana M., additional, Clark, Gregory O., additional, Dowell, Joshua D., additional, Draper, Jonathan S., additional, Evans, Martin, additional, Field, Loren J., additional, Fuller, Margaret T., additional, Gardner, Richard L., additional, Gavrilov, Svetlana, additional, Gearhart, John D., additional, Gersbach, Charles A., additional, Horb, Marko E., additional, Itskovitz-Eldor, Joseph, additional, Ji, Junfeng, additional, Johnson, Penny, additional, Jones, D. Leanne, additional, Kent, Kathleen C., additional, Kerr, Candace L., additional, Khademhosseini, Ali, additional, Klimanskaya, Irina, additional, Kraszewski, Jennifer N., additional, Kues, Wilfried A., additional, Landry, Donald W., additional, Langer, Robert, additional, Levenberg, Shulamit, additional, Littlefield, John W., additional, Lucas-Hahn, Andrea, additional, McLaren, Anne, additional, McMahon, Jill, additional, Martins-Green, M., additional, Mayshar, Yoav, additional, Melton, Douglas, additional, Mummery, Christine L., additional, Nagy, Andras, additional, Niemann, Heiner, additional, Nishikawa, Shin-Ichi, additional, Niwa, Hitoshi, additional, Okita, Keisuke, additional, Papaioannou, Virginia E., additional, Patterson, Ethan S., additional, Pébay, Alice, additional, Pera, Martin F., additional, Petreaca, M., additional, Price, Emily N., additional, Rossant, Jane, additional, Rubart, Michael, additional, Scadden, David T., additional, Schulz, Thomas, additional, Shamblott, Michael J., additional, Singh, Harvir, additional, Stocum, David L., additional, Thomson, James A., additional, Tosh, David, additional, Trounson, Alan, additional, Xu, Chunhui, additional, Yamamizu, Kohei, additional, Yamanaka, Shinya, additional, Yamashita, Jun K., additional, Young, Holly, additional, Zhong, Bonan, additional, Zon, Leonard I., additional, Zwaka, Thomas P., additional, and Zweigerdt, Robert, additional

Published
2013
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46. Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure

Author

Wehrens, Xander H.T., Lehnart, Stephan E., Reiken, Steven, van der Nagel, Roel, Morales, Raymond, Sun, Jie, Cheng, Zhenzhuang, Deng, Shi-Xiang, de Windt, Leon J., Landry, Donald W., and Marks, Andrew R.

Subjects
Calcium channels -- Research, Heart attack -- Research, Protein kinases -- Research, Science and technology
Abstract

Abnormalities in intracellular calcium release and reuptake are responsible for decreased contractility in heart failure (HF). We have previously shown that cardiac ryanodine receptors (RyRs) are protein kinase A-hyperphosphorylated and depleted of the regulatory subunit calstabin-2 in HF. Moreover, similar alterations in skeletal muscle RyR have been linked to increased fatigability in HF. To determine whether restoration of calstabin binding to RyR may ameliorate cardiac and skeletal muscle dysfunction in HF, we treated WT and calstabin-[2.sup.-/-] mice subjected to myocardial infarction (MI) with JTV519. JTV519, a 1,4-benzothiazepine, is a member of a class of drugs known as calcium channel stabilizers, previously shown to increase calstabin binding to RyR. Echocardiography at 21 days after MI demonstrated a significant increase in ejection fraction in WT mice treated with JTV519 (45.8 [+ or -] 5.1%) compared with placebo (31.1 [+ or -] 3.1%; P < 0.05). Coimmunoprecipitation experiments revealed increased amounts of calstabin-2 bound to the RyR2 channel in JTV519-treated WT mice. However, JTV519 did not show any of these beneficial effects in calstabin-[2.sup.-/-] mice with MI. Additionally, JTV519 improved skeletal muscle fatigue in WT and calstabin-[2.sup.-/-] mice with HF by increasing the binding of calstabin-1 to RyR1. The observation that treatment with JTV519 improved cardiac function in WT but not calstabin-[2.sup.-/-] mice indicates that calstabin-2 binding to RyR2 is required for the beneficial effects in failing hearts. We conclude that JTV519 may provide a specific way to treat the cardiac and skeletal muscle myopathy in HF by increasing calstabin binding to RyR. calcium | FKBP12.6 | myocardial infarction | contractility

Published
2005

48. Associate Editors

Author

Arend, William P., primary, Armitage, James O., additional, Clemmons, David R., additional, Drazen, Jeffrey M., additional, Griggs, Robert C., additional, Landry, Donald W., additional, Levinson, Wendy, additional, Rustgi, Anil K., additional, and Scheld, W. Michael, additional

Published
2012
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50. Contributors

Author

Abrams, Charles S., primary, Accurso, Frank J., additional, Afdhal, Nezam H., additional, Akin, Cem, additional, Aksamit, Allen J., additional, Al-Awqati, Qais, additional, Allos, Ban Mishu, additional, Altshuler, David, additional, Aminoff, Michael J., additional, Anderson, Jeffrey L., additional, Anderson, Karl E., additional, Anderson, Larry J., additional, Antman, Karen H., additional, Antony, Aśok C., additional, Appel, Gerald B., additional, Appelbaum, Frederick R., additional, Arend, William P., additional, Arguin, Paul, additional, Armitage, James O., additional, Armstrong, Cheryl A., additional, Arnaout, M. Amin, additional, Arnold, Robert, additional, Atkins, David, additional, Atkinson, William L., additional, Ausiello, Dennis, additional, Bacon, Bruce R., additional, Bagby, Grover C., additional, Bain, Barbara J., additional, Bajorin, Dean F., additional, Ballow, Mark, additional, Baloh, Robert W., additional, Barasch, Jonathan, additional, Barbano, Richard L., additional, Baron, Murray G., additional, Barrett-Connor, Elizabeth, additional, Barry, Michael J., additional, Barshop, Bruce A., additional, Bartlett, John G., additional, Barton, Mary, additional, Basner, Robert C., additional, Baum, Stephen G., additional, Bausch, Daniel G., additional, Bayer, Arnold S., additional, Bazari, Hasan, additional, Beigel, John H., additional, Beller, George A., additional, Bennett, Robert M., additional, Berger, Joseph R., additional, Berk, Paul, additional, Berliner, Nancy, additional, Bernat, James L., additional, Bierman, Philip J., additional, Bistrian, Bruce R., additional, Biundo, Joseph J., additional, Blanke, Charles D., additional, Blankson, Joel N., additional, Blaser, Martin J., additional, Blattner, William A., additional, Bleck, Thomas P., additional, Boden, William E., additional, Boland, C. Richard, additional, Bolognia, Jean, additional, Bonomo, Robert, additional, Borish, Larry, additional, Bosque, Patrick J., additional, Brand, Randall, additional, Brook, Itzhak, additional, Brunetti, Enrico, additional, Buchner, David M., additional, Buffet, Pierre A., additional, Bunn, H. Franklin, additional, Calabresi, Peter A., additional, Calfee, David P., additional, Calkins, Hugh, additional, Cameron, Douglas, additional, Camilleri, Michael, additional, Cannon, Grant W., additional, Cappellini, Maria Domenica, additional, Carabello, Blase A., additional, Carvalho, Edgar M., additional, Castellanos, Agustin, additional, Chalasani, Naga P., additional, Chambers, Henry, additional, Charlson, Mary, additional, Cheshire, William P., additional, Chinnery, Patrick F., additional, Christiani, David C., additional, Clemmons, David R., additional, Cohen, Jeffrey, additional, Cohen, Myron S., additional, Cohen, Steven P., additional, Cohn, Steven L., additional, Colebunders, Robert, additional, Connors, Joseph M., additional, Cook, Deborah J., additional, Corey, C. Ralph, additional, Cowan, Kenneth H., additional, Craig, William A., additional, Croft, Simon L., additional, Crow, Mary K., additional, Crump, John A., additional, Cullen, Mark R., additional, Curhan, Gary C., additional, Damon, Inger K., additional, Daniels, Troy E., additional, Davidson, Nancy, additional, DeAngelis, Lisa M., additional, DeCamp, Malcolm M., additional, Del Rio, Carlos, additional, Demetri, George D., additional, Demling, Robert H., additional, Deuster, Patricia A., additional, Diasio, Robert B., additional, Diemert, David J., additional, Digre, Kathleen B., additional, Douglas, John M., additional, Drazen, Jeffrey M., additional, Dreskin, Stephen C., additional, Drew, W. Lawrence, additional, Drusano, George L., additional, DuBose, Thomas D., additional, Duffy, F. Daniel, additional, DuPont, Herbert L., additional, Duvic, Madeleine, additional, Edwards, Kathryn M., additional, Edwards, N. Lawrence, additional, Einhorn, Lawrence H., additional, Elin, Ronald J., additional, Eliopoulos, George M., additional, Elliott, Perry, additional, Ellner, Jerrold J., additional, Elsas, Louis J., additional, Elston, Dirk M., additional, Emanuel, Ezekiel J., additional, Erickson, Gregory F., additional, Ernst, Armin, additional, Ernst, Joel D., additional, Ettinger, David S., additional, Evoli, Amelia, additional, Faigel, Douglas O., additional, Falk, Gary W., additional, Favus, Murray J., additional, Feder, Gene, additional, Fihn, Stephan D., additional, Firestein, Gary S., additional, Fishman, Neil, additional, Fleisher, Lee A., additional, Ford, Marsha D., additional, Forsmark, Chris E., additional, Fowler, Vance G., additional, Fox, Jay W., additional, Franco, Manuel A., additional, French, Martyn A., additional, Freund, Karen, additional, Fried, Linda P., additional, Gabay, Cem, additional, Gage, Kenneth L., additional, Gagel, Robert F., additional, Galgiani, John N., additional, Gallagher, Patrick G., additional, Galun, Eithan, additional, Ganz, Leonard, additional, Garcia-Tsao, Guadalupe, additional, Gates, Jonathan D., additional, Geisler, William M., additional, George, Tony P., additional, Gerding, Dale N., additional, Gershwin, M. Eric, additional, Gertz, Morie A., additional, Ginder, Gordon D., additional, Ginsberg, Jeffrey, additional, Ginsburg, Geoffrey S., additional, Glogauer, Michael, additional, Gnann, John W., additional, Golden, Matthew R., additional, Goldman, Lee, additional, Goldstein, Ellie J., additional, Goodnough, Lawrence T., additional, Goronzy, Jörg J., additional, Gotuzzo, Eduardo, additional, Grady, Deborah, additional, Grammer, Leslie C., additional, Greco, F. Anthony, additional, Greenberg, Harry B., additional, Gregersen, Peter K., additional, Griggs, Robert C., additional, Guay-Woodford, Lisa M., additional, Guerrant, Richard L., additional, Hadigan, Colleen, additional, Hainsworth, John D., additional, Hamsten, Anders, additional, Hande, Kenneth R., additional, Handsfield, H. Hunter, additional, Hansson, Göran K., additional, Haque, Rashidul, additional, Harris, Raymond C., additional, Hauser, Stephen Crane, additional, Hayden, Frederick G., additional, Healey, Letha, additional, Heimburger, Douglas C., additional, Hewlett, Erik L., additional, Hill, David R., additional, Hill, Nicholas S., additional, Hillis, L. David, additional, Hirsh, Jack, additional, Holers, V. Michael, additional, Holland, Steven M., additional, Hollenberg, Steven, additional, Hook, Edward W., additional, Huang, Laurence, additional, Hudson, Leonard D., additional, Hyman, Steven E., additional, Iannuzzi, Michael, additional, Inman, Robert D., additional, Inouye, Sharon K., additional, Insogna, Karl L., additional, Inzucchi, Silvio E., additional, Isselbacher, Eric M., additional, Jemal, Ahmedin, additional, Jen, Joanna, additional, Jensen, Dennis M., additional, Jensen, Michael D., additional, Jensen, Robert T., additional, Jessup, Mariell, additional, Johnson, Stuart, additional, Józefowicz, Ralph F., additional, Kaler, Stephen G., additional, Kamya, Moses R., additional, Kantarjian, Hagop, additional, Karp, David R., additional, Kastner, Daniel L., additional, Katzka, David A., additional, Katzman, Debra K., additional, Kauffman, Carol A., additional, Kaushansky, Kenneth, additional, Keeffe, Emmet B., additional, Kern, Morton, additional, Keusch, Gerald T., additional, Kim, David H., additional, Kim, Matthew, additional, Kirchhoff, Louis V., additional, Klag, Michael J., additional, Klein, Samuel, additional, Knopman, David S., additional, Knox, Tamsin A., additional, Ko, Albert I., additional, Komrokji, Rami S., additional, Kontoyiannis, Dimitrios P., additional, Koppel, Barbara S., additional, Korenblat, Kevin, additional, Korf, Bruce R., additional, Korman, Neil J., additional, Kovacs, Joseph A., additional, Kraft, Monica, additional, Kramer, Christopher M., additional, Krasnewich, Donna M., additional, Krause, Peter J., additional, Kronenberg, Henry M., additional, Kuipers, Ernst J., additional, Ladenson, Paul, additional, Landry, Donald W., additional, Lane, Nancy E., additional, Lang, Anthony E., additional, Lange, Richard A., additional, Lawry, George V., additional, Lee, Thomas H., additional, Lee, William M., additional, Leggett, James, additional, Lerner, Adam, additional, Levin, Stuart, additional, Levine, Stephanie M., additional, Lichtenstein, Gary R., additional, Lim, Henry W., additional, Lima, Aldo A.M., additional, Limper, Andrew H., additional, Ling, Geoffrey S.F., additional, List, Alan F., additional, Little, William C., additional, Loeser, Richard F., additional, Lorber, Bennett, additional, Low, Donald E., additional, Lucey, Daniel R., additional, Lupski, James R., additional, Lynch, Henry T., additional, Lyness, Jeffrey M., additional, Lytle, Bruce W., additional, MacKenzie, C. Ronald, additional, MacMillan, Harriet, additional, Madoff, Robert D., additional, Mahowald, Mark W., additional, Malhotra, Atul, additional, Mandell, Lionel A., additional, Manu, Peter, additional, Marcus, Marsha D., additional, Marelli, Ariane J., additional, Markman, Maurie, additional, Marks, Andrew R., additional, Marr, Kieren A., additional, Marrie, Thomas J., additional, Martin, Paul, additional, Mason, Joel B., additional, Massie, Barry M., additional, Masur, Henry, additional, Matteson, Eric L., additional, Maurer, Toby, additional, Mayer, Emeran A., additional, McClave, Stephen A., additional, McCool, F. Dennis, additional, McCulloch, Charles E., additional, McGuigan, Michael A., additional, McHutchison, John, additional, McKenna, William, additional, McLaughlin, Vallerie, additional, McMurray, John J.V., additional, McNaughton-Collins, Mary, additional, McQuaid, Kenneth, additional, Miller, Frederick W., additional, Minaker, Kenneth L., additional, Mink, Jonathan W., additional, Mishell, Daniel R., additional, Mitch, William E., additional, Molitch, Mark E., additional, Molitoris, Bruce A., additional, Montoya, José G., additional, Morady, Fred, additional, Moscow, Jeffrey A., additional, Murr, Andrew H., additional, Myerburg, Robert J., additional, Naguwa, Stanley, additional, Naides, Stanley J., additional, Nash, Theodore E., additional, Nath, Avindra, additional, Neilson, Eric G., additional, Neinstein, Lawrence S., additional, Newman, Thomas B., additional, Nichols, William L., additional, Nieman, Lynnette K., additional, Niewoehner, Dennis E., additional, Norrby, S. Ragnar, additional, Norris, David A., additional, O’Brien, Susan, additional, O’Connor, Francis G., additional, O’Connor, Patrick G., additional, O'Dell, James R., additional, O'Donnell, Anne E., additional, Oh, Jae K., additional, Olgin, Jeffrey E., additional, Olin, Jeffrey W., additional, Orenstein, Walter A., additional, Osmon, Douglas R., additional, Otto, Catherine M., additional, Paget, Stephen A., additional, Papania, Mark, additional, Pappas, Peter G., additional, Pasricha, Pankaj Jay, additional, Paterson, David L., additional, Patrono, Carlo, additional, Pawlotsky, Jean-Michel, additional, Pearson, Richard D., additional, Perencevich, Eli N., additional, Perl, Trish M., additional, Perry, Michael C., additional, Petri, William A., additional, Pfeffer, Marc A., additional, Pickhardt, Perry J., additional, Pier, Gerald B., additional, Pisetsky, David S., additional, Posner, Marshall R., additional, Prather, Charlene, additional, Pruitt, Basil A., additional, Pyeritz, Reed E., additional, Quinn, Thomas C., additional, Radhakrishnan, Jai, additional, Raghu, Ganesh, additional, Ragni, Margaret V., additional, Raja, Srinivasa N., additional, Rajkumar, S. Vincent, additional, Raoult, Didier, additional, Rebar, Robert W., additional, Reboli, Annette C., additional, Reddy, K. Rajender, additional, Redelmeier, Donald A., additional, Reef, Susan E., additional, Resnick, Neil M., additional, Reuben, David B., additional, Reynolds, Herbert Y., additional, Rivers, Emanuel P., additional, Rizza, Robert A., additional, Roberts, Lewis R., additional, Rolain, Jean-Marc, additional, Romero, José R., additional, Roodman, G. David, additional, Rosen, Clifford, additional, Rosene-Montella, Karen, additional, Rosenthal, Philip J., additional, Rothenberg, Marc E., additional, Rugo, Hope S., additional, Russell, James A., additional, Rustgi, Anil K., additional, Salata, Robert A., additional, Salmon, Jane E., additional, Santos, Renato M., additional, Sawka, Michael N., additional, Schafer, Andrew I., additional, Schaffner, William, additional, Scheld, W. Michael, additional, Schneider, Eileen, additional, Schnitzer, Thomas J., additional, Schooley, Robert T., additional, Schriger, David L., additional, Schroeder, Steven A., additional, Schuchter, Lynn M., additional, Schulman, Sam, additional, Schwartz, Lawrence B., additional, Schwartz, Robert S., additional, Seas, Carlos, additional, Seifert, Steven A., additional, Seifter, Julian L., additional, Semenkovich, Clay F., additional, Semrad, Carol E., additional, Service, F. John, additional, Shaw, George M., additional, Shaw, Pamela J., additional, Sherwin, Robert S., additional, Shy, Michael E., additional, Sibbitt, Wilmer L., additional, Sidransky, Ellen, additional, Siliciano, Robert F., additional, Simberkoff, Michael S., additional, Simel, David L., additional, Skorecki, Karl, additional, Slutsky, Arthur S., additional, Small, Eric J., additional, Smetana, Gerald W., additional, Southwick, Frederick S., additional, Spiera, Robert F., additional, Spinola, Stanley M., additional, Stankiewicz, Pawel, additional, Stark, Paul, additional, Steinbach, Lynne S., additional, Steinberg, Martin H., additional, Steiner, Theodore S., additional, Stephens, David S., additional, Stevens, David A., additional, Stevenson, William G., additional, Stillman, Arthur E., additional, Stoller, James K., additional, Stone, John H., additional, Su, Edwin P., additional, Sutter, Roland W., additional, Swartz, Morton N., additional, Swerdloff, Ronald S., additional, Sykes, Megan, additional, Tami, Thomas A., additional, Tarlo, Susan M., additional, Taylor, Victoria M., additional, Tefferi, Ayalew, additional, Teirstein, Paul S., additional, Telford, Sam R., additional, Tempero, Margaret, additional, Thun, Michael J., additional, Tolkoff-Rubin, Nina, additional, Tosti, Antonella, additional, Treanor, John J., additional, Turner, Ronald B., additional, Upton, Arthur C., additional, Van den Berghe, Greet, additional, Varga, John, additional, Vella, Adrian, additional, Verbalis, Joseph G., additional, Victor, Ronald G., additional, Vincent, Angela, additional, Volberding, Paul A., additional, Vose, Julie M., additional, Wachter, Robert M., additional, Wagner, Edward H., additional, Walsh, Edward E., additional, Walsh, Thomas J., additional, Wang, Christina, additional, Wanke, Christine, additional, Wasserman, Stephen I., additional, Wedemeyer, Heiner, additional, Weinberg, Geoffrey A., additional, Weinstein, David A., additional, Weinstein, Robert S., additional, Weiss, Roger D., additional, Weisse, Martin, additional, Weitz, Jeffrey I., additional, Wells, Samuel A., additional, Wenzel, Richard P., additional, Werth, Victoria P., additional, West, Sterling G., additional, Weyand, Cornelia M., additional, White, A. Clinton, additional, White, Christopher J., additional, White, Perrin C., additional, Whitley, Richard J., additional, Whyte, Michael P., additional, Wiebe, Samuel, additional, Wiener-Kronish, Jeanine P., additional, Wildes, Jennifer E., additional, Wilmer, Alexander, additional, Winkenwerder, William, additional, Wolfsdorf, Joseph I., additional, Wormser, Gary P., additional, Wysolmerski, John J., additional, Yanoff, Myron, additional, Young, Neal S., additional, Young, William F., additional, Yu, Alan S.L., additional, Zeidel, Mark L., additional, Zimetbaum, Peter, additional, and Zivin, Justin A., additional

Published
2012
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