Search

Your search keyword '"Landrock, Andreas"' showing total 7 results
Start Over Author "Landrock, Andreas"
7 results on '"Landrock, Andreas"'

1. Metabolomic tissue signature in human non-alcoholic fatty liver disease identifies protective candidate metabolites

Author

von Schönfels, Witigo, Patsenker, Eleonora, Fahrner, René, Itzel, Timo, Hinrichsen, Holger, Brosch, Mario, Erhart, Wiebke, Gruodyte, Auste, Vollnberg, Bernd, Richter, Klaus, Landrock, Andreas, Schreiber, Stefan, Brückner, Stephan, Beldi, Guido, Sipos, Bence, Becker, Thomas, Röcken, Christoph, Teufel, Andreas, Stickel, Felix, Schafmayer, Clemens, and Hampe, Jochen

Published
2015
Full Text
View/download PDF

2. Metabolic signature of electrosurgical liver dissection: 279

Author

von Schönfels, Witigo, von Kampen, Oliver, Patsenker, Eleonora, Stickel, Felix, Schniewind, Bodo, Hinz, Sebastian, Ahrens, Markus, Balschun, Katharina, Egberts, Jan Hendrik, Richter, Klaus, Landrock, Andreas, Sipos, Bence, Gavrilova, Olga, Huebbe, Patrica, Schreiber, Stefan, Michael, Nothnagel, Röcken, Christoph, Rimbach, Gerald, Becker, Thomas, Hampe, Jochen, and Schafmayer, Clemens

Published
2012

4. Metabolomic tissue signature in human non‐alcoholic fatty liver disease identifies protective candidate metabolites

Author

von Schönfels, Witigo, primary, Patsenker, Eleonora, additional, Fahrner, René, additional, Itzel, Timo, additional, Hinrichsen, Holger, additional, Brosch, Mario, additional, Erhart, Wiebke, additional, Gruodyte, Auste, additional, Vollnberg, Bernd, additional, Richter, Klaus, additional, Landrock, Andreas, additional, Schreiber, Stefan, additional, Brückner, Stephan, additional, Beldi, Guido, additional, Sipos, Bence, additional, Becker, Thomas, additional, Röcken, Christoph, additional, Teufel, Andreas, additional, Stickel, Felix, additional, Schafmayer, Clemens, additional, and Hampe, Jochen, additional

Published
2014
Full Text
View/download PDF

5. Metabolic Signature of Electrosurgical Liver Dissection

Author

von Schönfels, Witigo, primary, von Kampen, Oliver, additional, Patsenker, Eleonora, additional, Stickel, Felix, additional, Schniewind, Bodo, additional, Hinz, Sebastian, additional, Ahrens, Markus, additional, Balschun, Katharina, additional, Egberts, Jan-Hendrik, additional, Richter, Klaus, additional, Landrock, Andreas, additional, Sipos, Bence, additional, Will, Olga, additional, Huebbe, Patrizia, additional, Schreiber, Stefan, additional, Nothnagel, Michael, additional, Röcken, Christoph, additional, Rimbach, Gerald, additional, Becker, Thomas, additional, Hampe, Jochen, additional, and Schafmayer, Clemens, additional

Published
2013
Full Text
View/download PDF

6. S1850 Metabolomic Analysis of Breath Air and Tongue Swabs Using Gas Chromatography/Mass Spectrometry Identifies Novel Metabolic Markers of Hepatic Encephalopathy

Author

Vollnberg, Bernd O., primary, Günther, Rainer, additional, Buch, Stephan, additional, Schafmayer, Clemens, additional, Braun, Felix, additional, Hinrichsen, Holger M., additional, Sebens, Thorsten, additional, Schwerk, Wolf B., additional, Holst, Thomas, additional, Heukamp, Michael, additional, Becker, Dirk, additional, Landrock, Andreas, additional, Richter, Klaus, additional, Foelsch, Ulrich R., additional, and Hampe, Jochen, additional

Published
2009
Full Text
View/download PDF

7. Metabolomic tissue signature in human non-alcoholic fatty liver disease identifies protective candidate metabolites.

Author

Schönfels, Witigo, Patsenker, Eleonora, Fahrner, René, Itzel, Timo, Hinrichsen, Holger, Brosch, Mario, Erhart, Wiebke, Gruodyte, Auste, Vollnberg, Bernd, Richter, Klaus, Landrock, Andreas, Schreiber, Stefan, Brückner, Stephan, Beldi, Guido, Sipos, Bence, Becker, Thomas, Röcken, Christoph, Teufel, Andreas, Stickel, Felix, and Schafmayer, Clemens

Subjects
METABOLITES, LIVER diseases, LIVER failure, CELL surface antigens, BILIARY tract
Abstract

Background Non-alcoholic fatty liver disease ( NAFLD) is the most common chronic liver disorder in industrialized countries, yet its pathophysiology is incompletely understood. Small-molecule metabolite screens may offer new insights into disease mechanisms and reveal new treatment targets. Methods Discovery ( N = 33) and replication ( N = 66) of liver biopsies spanning the range from normal liver histology to non-alcoholic steatohepatitis ( NASH) were ascertained ensuring rapid freezing under 30 s in patients. 252 metabolites were assessed using GC/ MS. Replicated metabolites were evaluated in a murine high-fat diet model of NAFLD. Results In a two-stage metabolic screening, hydroquinone ( HQ, pcombined = 3.0 × 10−4) and nicotinic acid ( NA, pcombined = 3.9 × 10−9) were inversely correlated with histological NAFLD severity. A murine high-fat diet model of NAFLD demonstrated a protective effect of these two substances against NAFLD: Supplementation with 1% HQ reduced only liver steatosis, whereas 0.6% NA reduced both liver fat content and serum transaminase levels and induced a complex regulatory network of genes linked to NALFD pathogenesis in a global expression pathway analysis. Human nutritional intake of NA equivalent was also consistent with a protective effect of NA against NASH progression. Conclusion This first small-molecular screen of human liver tissue identified two replicated protective metabolites. Either the use of NA or targeting its regulatory pathways might be explored to treat or prevent human NAFLD. [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results