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Your search keyword '"Landeros, Natalia"' showing total 12 results
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12 results on '"Landeros, Natalia"'

7. The Reprimo-Like Gene Is an Epigenetic-Mediated Tumor Suppressor and a Candidate Biomarker for the Non-Invasive Detection of Gastric Cancer

Author

Alarcón, María, primary, Olivares, Wilda, additional, Córdova-Delgado, Miguel, additional, Muñoz-Medel, Matías, additional, de Mayo, Tomas, additional, Carrasco-Aviño, Gonzalo, additional, Wichmann, Ignacio, additional, Landeros, Natalia, additional, Amigo, Julio, additional, Norero, Enrique, additional, Villarroel-Espíndola, Franz, additional, Riquelme, Arnoldo, additional, Garrido, Marcelo, additional, Owen, Gareth, additional, and Corvalán, Alejandro, additional

Published
2020
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9. Abstract 2523: Loss of expression of wild-type transcript of CDH1 gene is associated with overexpression of microRNA-20 in diffuse-type of gastric cancer

Author

Landeros, Natalia, primary, Alarcon, Maria A., additional, Molina, Graciela, additional, Santoro, Pablo, additional, Torres, Keila, additional, Olivares, Wilda, additional, Wichmann, Ignacio, additional, Villarroel-Espindola, Franz, additional, Polakovicova, Iva, additional, Norero, Enrique, additional, and Corvalan, Alejandro H., additional

Published
2020
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10. Abstract 1400: An additive effect of ebv-miR-BART5-5p and hsa-miR18a-5p in the downregulation of CDH1 transcript in Epstein-Barr virus associated gastric cancer

Author

Torres, Keila, primary, Landeros, Natalia, additional, Wichmann, Ignacio, additional, Peñaloza-Otárola, Allan, additional, Polakovicova, Iva, additional, Maracaja-Coutinho, Vinicius, additional, Maturana, Maria Jose, additional, Villaroel-Espindola, Franz, additional, and Corvalan, Alejandro, additional

Published
2020
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11. Association of PALB2 sequence variants with the risk of familial and early-onset breast cancer in a South-American population

Author

Leyton, Yessica, primary, Gonzalez-Hormazabal, Patricio, additional, Blanco, Rafael, additional, Bravo, Teresa, additional, Fernandez-Ramires, Ricardo, additional, Morales, Sebastian, additional, Landeros, Natalia, additional, Reyes, Jose M, additional, Peralta, Octavio, additional, Tapia, Julio C, additional, Gomez, Fernando, additional, Waugh, Enrique, additional, Ibañez, Gladys, additional, Pakomio, Janara, additional, Grau, Gilberto, additional, and Jara, Lilian, additional

Published
2015
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12. Novel Risk Associations between microRNA Polymorphisms and Gastric Cancer in a Chilean Population.

Author

Landeros, Natalia, Corvalan, Alejandro H., Musleh, Maher, Quiñones, Luis A., Varela, Nelson M., and Gonzalez-Hormazabal, Patricio

Subjects
*STOMACH cancer, *LATIN Americans, *MICRORNA, *HELICOBACTER pylori, *CHILEANS
Abstract

Gastric cancer (GC) is the fifth leading cause of cancer deaths in the world, with variations across geographical regions and ethnicities. Emerging evidence indicates that miRNA expression is dysregulated in GC and its polymorphisms may contribute to these variations, which has yet to be explored in Latin American populations. In a case-control study of 310 GC patients and 311 healthy donors from Chile, we assessed the association of 279 polymorphisms in 242 miRNA genes. Two novel polymorphisms were found to be associated with GC: rs4822739:C>G (miR-548j) and rs701213:T>C (miR-4427). Additionally, rs1553867776:T>TCCCCA (miR-4274) and rs12416605:C>T (miR-938) were associated with intestinal-type GC, and rs4822739:C>G (miR-548j) and rs1439619:T>G (miR-3175) with TNM I-II stage. The polymorphisms rs6149511:T> TGAAGGGCTCCA (miR-6891), rs404337:G>A (miR-8084), and rs1439619:T>G (miR-3175) were identified among H.pylori-infected GC patients and rs7500280:T>C (miR-4719) and rs1439619:T>G (miR-3175) were found among H. pylori cagPAI+ infected GC cases. Prediction analysis suggests that seven polymorphisms could alter the secondary structure of the miRNA, and the other one is located in the seed region of miR-938. Targets of miRNAs are enriched in GC pathways, suggesting a possible biological effect. In this study, we identified seven novel associations and replicated one previously described in Caucasian population. These findings contribute to the understanding of miRNA genetic polymorphisms in the GC pathogenesis. [ABSTRACT FROM AUTHOR]

Published
2022
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